Hub : Genes

SLC39A10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.0870	0.0440	6.2e-03	0.038	NA	0.046	NA	0.031	4.7e-03	NA	2.1e-03	NA	9.3e-03
2	GTEx	Artery Tibial	0.1005	0.0351	2.1e-05	0.083	NA	0.055	NA	0.065	4.4e-07	NA	3.9e-05	NA	8.1e-06
3	GTEx	Breast Mammary Tissue	0.1010	0.0440	2.5e-03	0.084	NA	0.032	NA	0.039	4.2e-05	NA	8.6e-03	NA	4.2e-03
4	GTEx	Breast Mammary Tissue (Male)	0.0804	0.0629	1.2e-01	0.047	NA	0.011	NA	0.011	3.1e-02	NA	1.8e-01	NA	1.7e-01
5	GTEx	Cells Transformed fibroblasts	0.1040	0.0360	3.9e-05	0.104	NA	0.077	NA	0.099	3.6e-08	NA	2.0e-06	NA	6.8e-08
6	GTEx	Esophagus Muscularis	0.0740	0.0380	7.1e-03	0.031	NA	0.006	NA	0.019	5.7e-03	NA	1.2e-01	NA	2.4e-02
7	GTEx	Nerve Tibial	0.1445	0.0480	6.1e-05	0.071	NA	0.072	NA	0.071	9.2e-06	NA	7.8e-06	NA	9.7e-06
8	GTEx	Thyroid	0.0780	0.0410	9.4e-03	0.060	NA	0.028	NA	0.048	2.1e-05	NA	3.1e-03	NA	1.5e-04
9	ROSMAP	Brain Pre-frontal Cortex	0.2347	0.0420	0.0e+00	0.270	0.279	0.315	0.299	0.293	1.3e-34	5.4e-36	2.3e-41	7.4e-39	5.1e-38
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0771	0.0407	1.9e-03	0.016	0.023	0.018	NA	0.026	6.0e-03	1.1e-03	3.4e-03	NA	5.4e-04
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0289	0.0166	1.2e-03	0.028	0.024	0.019	NA	0.020	3.6e-04	8.3e-04	2.9e-03	NA	2.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.2	1.9	3.5	0.7	1.5	1.3	-0.3	1.7	0.4	1.9	1.9	0.4	1.5	1.8
Bipolar Disorder or Schizophrenia	1.6	4.0	13.7	0.8	1.5	2.9	0.7	2.0	2.1	1.7	3.7	1.0	1.5	1.8
Depressed Affect (Nagel 2018)	0.6	1.2	3.5	0.6	1.3	-0.9	1.2	1.4	0.7	1.0	-1.0	-1.9	1.0	0.2
Depression (Nagel 2018)	0.7	1.1	4.3	-0.2	1.1	-1.0	2.1	0.6	-0.0	1.1	-0.9	-1.5	1.2	0.2
Intelligence (Savage-Jansen 2018)	0.4	1.2	5.3	0.7	1.2	-0.8	-0.2	1.1	0.4	1.7	-0.8	-0.4	2.3	0.4
Neuroticism (Nagel 2018)	1.5	3.5	6.9	1.4	2.4	-0.4	1.6	2.4	1.6	2.6	-0.7	-2.4	2.4	0.9
Schizophrenia (2018)	1.3	2.7	10.5	0.3	0.7	2.7	1.1	1.2	2.4	0.7	3.2	0.9	0.7	0.8
Schizophrenia vs Biploar Disorder	1.1	1.5	5.1	-1.0	-1.6	-0.0	-0.8	-1.3	1.1	-2.2	0.0	1.5	-0.8	-1.3
Worry (Nagel 2018)	3.5	7.4	13.2	2.5	3.4	1.9	1.3	3.6	3.1	3.6	1.4	-2.1	3.1	2.3
Alzheimer’s Disease (in mother)	0.9	1.0	4.2	-2.0	-0.2	1.4	-0.5	-0.4	-0.7	-0.1	1.3	1.2	-0.5	0.9
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.7	0.3	1.1	0.3	0.4	-0.8	-0.6	0.1	-1.0	-0.3	0.7
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-1.1	0.4	1.3	-0.2	0.3	-0.8	-0.0	1.1	0.3	-0.3	1.2
Crohns Disease (2017)	1.3	2.9	10.0	3.2	1.9	-0.4	1.7	1.4	1.0	1.4	0.3	-2.1	1.5	2.0
Irritable Bowel Disease (IBD)	1.3	3.1	9.2	3.0	1.8	0.8	1.6	1.6	0.8	1.1	1.3	-2.3	0.5	2.6
Ulcerative Colitis (UC)	0.7	1.2	3.2	1.8	0.6	1.4	0.4	1.1	0.3	0.3	1.6	-0.9	-0.3	1.8
Major Depression (MDD)	1.1	1.3	3.2	1.8	0.9	1.5	1.5	1.0	0.8	1.1	1.5	-0.2	0.6	0.5
Reaction Time	0.4	0.8	3.1	1.8	-0.9	0.1	0.8	-0.6	0.3	-1.2	-0.5	-0.3	-1.4	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.7	1.9	1.4	-0.3	-0.1	1.1	0.9	1.0	-0.5	-1.0	1.4	1.1
Breast Cancer	0.1	0.2	0.6	-0.4	0.2	-0.6	0.4	-0.1	0.3	0.2	-0.1	0.4	0.8	0.7
Ovarian Cancer	0.2	0.3	1.3	0.3	0.2	-0.7	0.4	-0.1	-0.4	0.4	-1.1	-0.8	0.3	-0.1
Prostate Cancer	0.6	0.9	2.6	0.7	0.1	1.0	-0.2	0.1	0.9	1.2	1.3	1.6	1.1	0.9
Age at First Birth	0.3	0.4	1.4	-0.3	0.4	0.7	0.6	0.5	1.2	0.1	0.0	-0.5	-0.2	1.2
Bipolar Disorder (2011)	6.1	5.9	11.2	0.8	2.9	2.7	1.2	3.4	2.9	2.4	2.7	-1.1	2.3	2.9
Body Mass Index (BMI) (2010)	0.7	0.9	2.2	1.2	1.3	0.6	0.6	1.3	1.5	0.5	0.6	-0.9	0.9	0.6
Coronary Artery Disease (CAD)	0.2	0.2	1.2	-1.1	0.3	-0.7	-0.5	0.0	0.1	-0.2	-0.2	-0.3	0.0	0.2
Crohns Disease (2012)	1.6	2.6	6.2	2.5	1.7	-0.3	2.2	1.5	1.8	1.4	0.1	-2.1	1.1	1.4
Mean Putamen Volume	0.3	0.3	1.0	0.6	-0.3	0.3	-0.0	-1.0	-0.8	-0.6	-0.1	0.3	-0.9	0.0
Fasting Glucose	0.9	1.0	2.9	1.2	1.1	-0.1	1.7	1.4	0.6	0.2	0.0	-1.7	-0.2	0.8
HbA1C	0.5	0.6	1.5	0.8	-1.0	0.3	0.2	-0.9	-0.1	-0.5	0.2	1.0	-1.1	-1.2
HDL Cholesterol	0.3	0.4	0.8	-0.3	-0.9	-0.8	-0.6	-0.9	-0.6	-0.5	-0.7	0.1	-0.6	-0.8
LDL Cholesterol	0.2	0.3	0.8	-0.4	-0.7	0.4	-0.7	-0.2	0.2	-0.3	0.4	0.9	-0.2	-0.8
Lupus	0.9	1.4	4.4	1.4	1.4	0.3	2.1	1.4	0.6	0.7	0.2	-1.3	1.3	0.6
Neuroticism (2016)	1.4	2.0	4.5	0.5	1.9	0.6	2.1	1.8	1.4	1.4	0.4	-2.0	1.4	0.5
Primary Biliary Cirrhosis	0.1	0.2	1.0	-0.4	-0.3	-0.5	-1.0	0.0	-0.3	0.3	-0.1	0.6	0.3	-0.4
Rheumatoid Arthritis	0.2	0.3	1.2	-0.1	-0.2	-0.9	0.3	-0.1	-0.1	1.0	-0.6	-0.1	0.3	-1.1
Schizophrenia (2014)	0.8	1.7	6.6	0.7	0.8	1.6	0.8	1.4	2.6	0.1	2.1	0.6	0.8	0.9
Triglycerides	0.5	0.8	2.2	-0.7	0.9	1.4	-0.9	1.5	0.7	0.9	0.4	0.0	0.9	0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.9	-0.3	0.0	-0.8	-0.2	-0.5	-1.1	-1.4	-0.7	0.1	-0.2	-0.1
Ulcerative Colitis	1.6	2.3	7.5	1.1	1.8	0.9	0.4	2.2	1.3	1.7	0.8	-1.4	0.8	2.7
Blood Eosinophil Count	1.4	10.9	21.9	2.8	3.4	4.5	1.6	3.8	4.0	2.2	4.7	-2.6	1.3	3.4
Blood Platelet Count	0.2	2.5	6.6	-0.7	-2.5	0.9	-0.7	-1.9	-1.0	-0.8	0.4	1.9	-2.1	-2.6
Blood Red Count	0.6	6.2	10.7	1.6	3.1	1.9	2.9	2.9	0.8	2.9	1.9	-2.2	3.3	2.7
Blood White Count	0.1	0.8	1.8	0.5	-1.1	-0.2	0.9	-1.3	-0.7	-0.7	0.1	1.0	-0.7	-1.3
Heel T-Score	2.1	17.1	45.3	-0.6	-3.8	-6.7	-1.4	-4.4	-5.1	-4.0	-6.6	0.6	-2.8	-3.5
BMI	0.4	2.2	5.7	-0.8	-1.6	-0.4	-2.4	-1.3	-1.8	-1.3	-0.3	1.8	-1.8	-1.4
Height	0.1	1.0	5.2	-0.7	-0.9	-0.4	-1.2	-0.3	-1.5	-0.0	0.5	2.3	0.3	-0.6
Waist Hip Ratio (WHR)	0.4	1.6	3.6	-1.8	-1.1	-0.2	-1.7	-1.6	-1.5	-0.4	-0.3	1.9	0.0	-1.3
Systolic Blood Pressure	0.8	3.8	8.8	-0.8	-2.5	-1.3	-1.3	-2.7	-2.5	-1.6	-1.1	3.0	-0.7	-2.3
Smoking Status	1.7	4.0	7.5	-2.1	-2.3	-1.6	-2.2	-1.9	-2.7	-2.6	-1.7	1.5	-2.0	-0.9
Allergy or Eczema	1.4	3.8	5.3	2.2	2.2	1.4	1.6	2.3	2.2	2.3	2.0	-1.1	2.0	1.7
Cardiovascular Disease	0.8	2.6	4.2	-1.3	-1.5	-1.9	-0.2	-2.0	-1.9	-1.4	-1.7	-0.5	-2.1	-1.8
Hypothyroidism (self reported)	0.2	0.5	1.9	-0.6	0.8	0.0	0.6	1.0	0.9	-0.3	-0.4	-1.4	0.1	0.7
Respiratory disease	0.5	1.1	3.7	-0.4	1.1	-0.2	-0.8	1.9	1.3	1.2	-0.1	-0.2	1.5	0.7
Type 2 Diabetes (T2D) (2018)	4.4	8.3	11.6	-2.5	-3.4	-3.0	-3.4	-3.3	-3.0	-2.0	-3.1	3.1	-1.3	-2.9
Lung FEV1/FVC ratio	0.2	1.2	3.5	-0.1	-1.2	0.3	1.6	-1.2	-1.9	-1.1	0.1	-0.2	-1.3	-1.3
Lung FVC	0.1	0.6	3.2	-0.1	-0.4	-0.7	-0.1	-0.8	-1.8	-1.1	-0.3	0.1	-0.4	-0.8
Neuroticism	1.5	3.5	7.3	1.3	2.3	0.6	2.2	2.6	0.9	2.7	0.5	-2.4	2.0	1.2
Chronotype (morning person)	0.4	1.0	3.7	0.8	0.8	1.7	-0.2	0.5	1.2	0.7	1.9	0.2	0.3	1.0
Hair Pigment	0.4	10.9	18.2	-2.4	-3.8	-3.3	-1.3	-4.1	-4.1	-4.3	-2.4	1.8	-3.5	-3.6
Tanning	0.1	1.3	2.2	-0.8	-1.4	-1.4	-1.4	-1.0	-0.7	-1.2	-1.0	1.5	-0.3	-1.1
Hand grip strength (left)	0.4	1.1	4.7	-0.8	-0.9	0.1	-1.1	-1.3	-1.1	-0.6	0.5	2.2	0.5	-0.7
Number of treatments/medications taken	0.3	0.6	1.9	-0.0	0.6	1.1	0.1	0.4	0.3	1.4	1.4	0.5	0.7	0.6
Average weekly spirits intake	2.3	2.9	6.7	-0.5	-2.5	-0.7	-0.5	-2.6	-1.5	-1.7	-0.4	1.9	-1.8	-2.4
Sensitivity / hurt feelings	1.4	2.4	6.2	0.1	1.9	1.9	1.2	1.7	1.0	2.2	1.4	-0.6	2.5	1.2
Frequency of depressed mood in last 2 weeks	1.6	2.3	5.6	0.4	1.8	0.0	2.3	1.6	1.3	1.8	-0.2	-1.7	2.4	0.8
Hearing difficulty/problems: Yes	2.0	3.0	9.3	0.7	1.8	1.4	1.0	2.3	1.8	2.3	1.4	0.5	3.1	1.1
Relative age of first facial hair	1.0	2.0	4.5	-0.2	-1.2	-0.8	-2.0	-1.1	-2.1	-2.0	-1.3	-0.0	-2.0	-0.8
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.8	1.6	1.4	0.3	1.5	1.7	1.6	1.2	0.3	-1.1	1.0	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.3	0.2	1.4	0.6	-0.2	1.0	1.1	1.6	0.9	0.2	1.8	1.1
Ever had hysterectomy (womb removed)	0.8	0.9	3.5	0.7	0.2	-1.5	-1.9	-0.1	-0.2	-1.0	-1.4	0.1	-0.1	0.6
Systolic blood pressure, automated reading	1.9	5.4	13.1	-1.4	-3.1	-0.6	-2.2	-3.0	-2.7	-2.2	-0.3	3.6	-1.9	-2.2
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	10.0	-3.2	-1.0	-0.8	-1.8	-0.9	-0.7	0.1	-0.3	1.5	-0.4	-0.8
Angina	0.9	1.1	2.3	1.2	1.0	1.5	0.2	0.9	1.1	0.8	1.3	0.1	1.3	1.3
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.9	-0.0	-1.2	-0.4	0.2	0.0	0.5	-0.9	0.7	1.2	-0.4
Vitamin and mineral supplements	3.8	5.1	8.6	-1.8	-2.9	-1.2	-2.6	-2.5	-1.7	-2.2	-1.5	2.9	-1.8	-2.8
Supplements: Zinc	2.7	2.9	11.0	0.1	-0.8	-3.3	0.5	-0.9	-1.6	-1.6	-3.1	-1.6	-1.0	-1.1
Medication: Co-codamol	0.6	0.7	2.5	-1.0	-1.1	-0.2	-0.6	-0.7	0.1	-0.9	0.1	1.6	-0.8	-0.9
Medication: Metformin	2.9	4.1	7.1	-1.4	-2.7	-1.4	-2.4	-2.5	-1.6	-2.2	-1.5	2.5	-1.6	-2.0
Diabetes (father)	0.8	0.9	3.9	0.0	-0.6	-1.7	-0.7	-0.5	-0.4	-0.7	-2.0	-0.7	-0.9	-0.6
Diabetes (mother)	2.0	2.5	5.7	-2.0	-1.5	-2.2	-0.9	-1.6	-1.9	-0.4	-2.4	1.4	0.7	-1.3
Severe depression (siblings)	0.2	0.3	1.0	-0.7	-0.2	-0.2	0.2	-0.9	0.0	-1.0	-0.3	-0.5	-0.3	-0.3
Pack years adult smoking proportion	0.2	0.3	1.1	0.1	-0.5	-0.0	-1.1	-0.4	0.6	0.0	0.0	0.8	-0.4	-0.3
Impedance of leg (right)	0.1	0.4	1.5	-1.2	-0.1	-1.0	-0.1	-0.2	-0.8	-0.4	-0.8	-0.3	0.2	-0.2
Leg fat-free mass (left)	0.1	0.4	1.5	0.2	-0.8	-0.4	-0.9	-0.2	-0.2	-0.5	0.0	1.2	-0.4	-0.7
Trunk fat percentage	1.1	4.3	9.2	-1.2	-2.5	0.0	-3.0	-2.0	-1.7	-2.4	0.1	2.6	-2.7	-1.7
Hand grip strength (right)	0.6	1.7	3.5	-0.9	-1.4	-1.0	-1.4	-1.5	-1.8	-1.2	-0.6	1.9	0.1	-1.6
Townsend deprivation index at recruitment	3.0	4.2	9.2	-0.5	-2.9	-0.9	-1.4	-2.3	-1.9	-2.5	-1.0	2.3	-1.8	-3.0
Current tobacco smoking	5.1	8.4	15.2	-2.6	-3.4	-1.6	-2.4	-3.4	-3.6	-3.9	-1.8	1.9	-3.8	-2.2
Average weekly fortified wine intake	0.5	0.5	1.8	0.6	0.8	0.8	0.0	0.8	0.8	0.6	0.5	-0.8	0.1	1.4
Maternal smoking around birth	4.1	6.0	13.6	-3.0	-2.6	-1.8	-2.2	-2.3	-3.7	-2.8	-1.7	1.6	-2.4	-2.1
Fed-up feelings	0.4	0.7	2.8	-0.5	-0.4	-1.5	0.6	-0.2	-0.8	-0.3	-1.7	-0.4	0.0	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.6	-0.8	0.6	-1.9	1.9	0.2	-0.7	0.5	-1.6	-1.5	1.1	-0.4
Relative age voice broke	0.2	0.4	0.8	0.1	-0.3	-0.8	-0.7	-0.5	-0.9	-0.9	-0.9	-0.4	-0.3	0.2
Taking other prescription medications	0.7	1.1	2.1	1.1	1.2	0.0	1.3	1.1	0.9	1.5	0.5	-1.0	1.5	0.5
Age when periods started (menarche)	1.8	4.3	7.5	1.9	2.2	2.7	0.7	2.5	2.1	2.0	2.6	-0.6	2.2	2.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	-0.5	0.6	0.1	0.5	0.3	0.8	-0.1	0.8	0.5	0.8	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	8.1	0.7	-2.0	-2.2	-0.2	-2.4	-1.8	-2.9	-2.4	-0.4	-2.8	-1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	3.2	0.3	0.7	0.8	1.8	0.2	-0.3	1.1	0.8	-0.5	0.5	0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.7	0.1	-0.7	-0.2	0.1	0.2	0.6	-0.1	0.5	0.7	-0.6
Serious illness, injury or assault to yourself	2.3	2.8	7.4	0.2	2.4	-0.3	1.0	1.3	1.5	2.1	0.3	-1.8	2.7	2.1
High blood pressure	0.4	1.1	4.3	-0.1	-1.3	-0.0	0.2	-1.5	-1.4	-0.7	0.4	0.1	-2.1	-1.4
Hayfever, allergic rhinitis or eczema	1.4	3.1	4.5	1.7	2.0	1.4	1.6	1.9	1.8	2.1	2.1	-0.6	2.0	1.6
Multivitamins +/- minerals	2.4	3.0	6.9	1.2	2.1	0.1	2.3	2.5	1.5	1.7	0.4	-2.6	1.2	1.6
Stomach or abdominal pain in last month	0.3	0.4	1.3	0.3	-0.6	-0.7	0.6	-1.2	-0.5	0.1	-0.7	-0.4	-0.3	-0.6
Supplements: Glucosamine	0.4	0.5	2.0	1.2	-0.0	0.0	0.7	0.3	0.0	-0.2	-0.2	-1.4	-1.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	-0.8	-0.6	0.9	0.1	-0.7	0.9	0.4	0.8	1.0	0.0	-0.8
Medication: Atenolol	0.7	0.8	3.8	-1.2	0.8	0.1	-0.6	0.3	0.0	1.9	0.4	0.4	1.4	0.8
Medication: Levothyroxine sodium	0.3	0.4	1.4	-0.8	-0.1	0.7	1.0	0.5	1.2	-0.6	0.1	-0.4	-0.5	-0.2
Sitting height	0.4	3.0	6.3	0.5	2.5	-0.0	1.2	2.4	1.8	1.8	0.8	-1.4	2.5	2.0
Chronic bronchitis/emphysema (father)	0.8	1.0	4.4	-0.2	-0.2	-2.0	-0.1	0.3	0.5	0.2	-2.1	-1.0	-0.3	-1.1
High blood pressure (mother)	0.5	0.7	3.5	0.8	0.9	-0.8	1.0	0.2	0.1	0.3	-1.0	-1.9	0.1	0.4
Body mass index (BMI)	0.9	4.0	6.5	-1.1	-2.4	-0.3	-2.5	-2.2	-2.2	-2.1	-0.4	2.1	-2.5	-2.2
Impedance of leg (left)	0.2	0.8	2.7	-1.6	-0.6	-1.1	-0.7	-0.7	-1.2	-0.9	-0.9	0.3	-0.2	-0.3
Leg predicted mass (left)	0.1	0.4	1.5	0.2	-0.9	-0.4	-0.9	-0.3	-0.2	-0.6	-0.0	1.2	-0.5	-0.8
Trunk fat mass	0.9	3.7	7.3	-1.1	-2.4	-0.2	-2.7	-1.9	-1.8	-2.2	0.0	2.4	-2.5	-1.8
Waist circumference	0.9	3.3	6.0	-1.2	-2.1	-0.1	-2.5	-1.9	-2.4	-1.5	-0.1	2.3	-2.0	-1.8
Number of incorrect matches in round	0.6	1.0	2.2	0.8	-0.8	1.4	1.0	0.3	1.4	-0.1	1.5	1.2	-1.1	-0.6
Past tobacco smoking	0.7	1.3	2.9	0.6	1.4	-0.2	1.6	1.1	1.6	0.8	-0.1	-1.7	1.0	0.7
Alcohol usually taken with meals	3.3	5.3	9.2	1.5	2.3	2.3	2.6	3.0	2.9	1.9	2.7	-1.2	1.7	2.4
Nervous feelings	1.6	2.9	6.9	1.5	2.2	1.3	0.9	2.1	1.4	2.6	0.6	-1.6	2.1	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	5.2	1.3	2.3	0.6	2.1	2.1	1.3	2.1	0.7	-1.7	2.2	0.8
Hearing difficulty/problems with background noise	1.7	2.7	6.5	2.5	1.9	0.1	1.8	1.8	1.0	1.9	-0.4	-1.1	2.5	0.8
Hair/balding pattern: Pattern 2	0.3	0.3	1.0	-0.8	0.5	-0.4	-0.5	0.8	1.0	-0.0	0.2	-0.5	0.4	0.5
Had menopause	0.4	0.5	1.4	-0.4	0.1	0.3	-1.1	0.3	0.2	1.1	0.4	1.2	0.8	0.0
Had other major operations	0.4	0.4	1.8	-1.4	0.5	-0.6	-0.8	0.7	0.7	0.5	-0.5	-0.0	0.6	-0.0
Forced vital capacity (FVC)	0.4	1.7	4.3	-1.4	-0.9	-1.9	-1.2	-1.4	-2.1	-0.8	-1.0	1.2	0.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	7.2	1.1	-1.7	-2.5	-0.2	-1.8	-1.7	-1.9	-2.7	0.0	-1.5	-1.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	0.3	0.7	0.7	1.0	1.1	1.0	0.2	0.9	-0.5	0.3	0.1
Qualifications: None of the above	0.1	0.2	0.4	0.2	0.4	-0.6	-0.6	0.1	-0.3	0.4	-0.5	-0.7	0.0	0.2
Financial difficulties in last 2 years	1.2	1.7	3.9	-0.1	-0.8	-1.7	0.0	-1.4	-1.2	-1.6	-2.0	-1.0	-1.2	-1.5
Mouth/teeth dental problems	0.2	0.3	1.2	0.1	0.7	0.4	-0.0	0.4	0.7	0.8	0.5	-0.1	0.6	1.1
Heart attack	1.5	1.9	4.2	0.7	2.1	0.6	0.6	1.9	1.2	1.9	0.5	-1.4	1.8	1.2
Allergy	1.3	3.0	5.5	-1.2	-1.9	-1.7	-1.4	-2.0	-1.4	-2.4	-2.2	0.8	-1.7	-1.7
Pain all over the body in last month	1.4	1.5	5.5	-1.5	-1.3	-0.2	-1.8	-1.8	0.1	-0.1	-0.0	2.4	0.3	-0.7
Diabetes (self-reported)	3.6	5.6	9.3	-3.1	-2.6	-2.4	-3.0	-2.4	-2.3	-1.2	-2.6	2.2	-1.2	-2.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	0.9	-0.3	-0.1	-1.0	-0.7	0.4	-0.4	0.1	0.6	-0.2	0.2
Medication: Ramipril	1.6	2.1	3.8	-1.6	-1.9	-1.0	-1.9	-1.6	-1.3	-0.8	-0.8	1.9	-0.7	-1.6
Medication: Simvastatin	1.0	1.5	3.8	-1.6	-1.5	0.2	-1.4	-1.1	-1.6	-0.7	0.5	1.9	-0.7	-1.2
Fluid intelligence score	1.0	2.0	5.8	1.2	1.9	-0.4	0.1	1.8	1.2	2.0	-0.5	-1.0	2.4	1.1
Illnesses of siblings	0.2	0.3	0.9	-0.3	-0.4	-0.1	-0.9	-0.9	-0.9	-0.3	-0.0	0.7	0.5	-0.3
Neuroticism score	1.2	2.6	4.9	0.3	2.2	1.3	1.4	2.1	0.9	2.2	0.8	-2.0	1.7	1.3
Weight	0.7	3.5	5.3	-1.1	-2.2	-0.8	-2.3	-2.0	-2.3	-2.1	-0.5	2.2	-2.0	-2.0
Impedance of arm (right)	0.2	0.8	2.8	1.0	0.7	-0.4	0.7	1.0	1.7	0.4	-0.5	-1.1	0.7	0.9
Arm fat percentage (right)	0.7	2.6	6.5	-0.3	-2.1	0.0	-1.9	-1.8	-1.3	-1.9	-0.1	1.6	-2.5	-1.9
Trunk fat-free mass	0.0	0.1	0.5	0.0	-0.2	-0.5	0.1	-0.1	-0.7	-0.1	0.0	0.5	0.1	-0.6
Hip circumference	0.4	1.6	3.3	-0.6	-1.6	-0.4	-1.5	-1.1	-1.6	-1.4	-0.2	1.4	-1.8	-1.1
Time employed in main current job	0.6	0.7	3.0	-0.8	-0.0	1.7	-0.5	-0.2	-0.4	-0.4	1.2	0.3	-0.6	1.4
Alcohol intake versus 10 years previously	1.0	1.5	4.3	-0.7	-1.1	-1.4	-1.7	-0.7	-1.0	-1.5	-2.1	0.4	-1.3	-0.8
Father’s age at death	0.8	1.1	3.1	0.8	1.5	0.0	0.3	0.9	1.0	1.5	-0.2	-1.8	0.9	0.6
Worrier / anxious feelings	2.5	4.7	8.3	0.8	2.9	1.4	1.5	2.9	2.4	2.8	0.9	-2.1	2.7	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.8	0.4	0.1	-1.3	1.2	-0.4	0.4	0.2	-1.4	-0.9	0.2	-0.8
Falls in the last year	0.2	0.2	0.9	-0.1	0.2	-0.6	0.6	0.7	-0.2	-0.4	-0.4	-0.9	-0.2	0.1
Hair/balding pattern: Pattern 3	0.9	1.4	3.0	0.2	-0.8	-1.4	0.9	-0.5	-1.5	-0.7	-1.5	-1.4	-1.7	-1.1
Number of live births	1.0	1.5	2.9	-1.7	-1.4	-0.8	-0.6	-1.1	-1.6	-0.8	-0.7	1.0	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.8	-0.9	-1.4	-1.7	-0.7	-1.8	-2.2	-1.4	-0.7	1.2	-0.3	-1.5
Pulse rate	0.7	1.2	3.8	-0.1	-1.1	0.8	-0.8	-1.3	-0.7	-1.6	1.1	0.8	-1.9	-0.8
Happiness	0.7	0.9	2.5	0.6	0.8	-0.0	1.6	1.1	1.5	0.6	0.1	-0.2	1.5	-0.3
Noisy workplace	0.7	0.8	2.8	0.1	0.0	1.2	-0.1	-0.8	-1.5	0.3	1.7	1.2	0.0	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.2	-0.9	-1.1	-0.6	-0.7	-0.4	-0.6	-0.7	-0.5	1.1	-0.5	-0.7
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.5	6.0	0.1	2.2	0.9	0.1	1.9	2.2	2.0	0.7	-0.7	2.5	1.3
Mouth/teeth dental problems: Dentures	0.8	1.4	5.2	-0.9	-1.5	-0.2	-0.7	-1.0	-1.5	-1.4	-0.4	0.4	-2.3	-1.2
Asthma	1.1	2.2	5.4	0.4	2.0	0.8	-0.2	2.1	1.5	1.9	1.1	-0.3	2.3	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.6	0.8	0.2	-0.4	0.8	-0.1	-0.4	-0.1	-0.0	0.1	0.4	-0.2
Medication: Cholesterol lowering	0.9	1.4	5.4	0.8	-0.2	2.3	-0.4	0.0	0.9	0.9	2.0	1.8	0.7	-0.3
Depression (self-reported)	1.2	1.5	4.4	0.3	1.5	0.1	2.1	1.2	0.7	1.7	0.3	-1.2	1.7	0.4
Medication: Lansoprazole	0.5	0.6	2.0	-0.3	0.3	0.0	-1.1	0.4	0.6	1.3	0.1	0.3	1.4	0.6
Prospective memory result	0.2	0.2	1.3	0.0	-0.3	-0.6	0.0	-0.2	0.1	1.1	-0.6	0.5	0.3	-0.0
Lung cancer (father)	0.6	0.7	3.0	0.8	0.3	-0.7	-0.8	0.4	-0.0	1.1	-1.0	0.3	1.7	-0.2
Illnesses of mother	0.2	0.2	1.5	1.2	-0.3	0.1	0.6	0.2	0.1	-0.6	0.4	0.1	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.0	-0.2	-1.0	-1.3	0.1	-1.3	-1.4	-1.2	-0.5	0.9	-0.0	-1.4
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	0.8	0.9	-0.3	-0.2	0.6	-0.2	0.1	-0.0	-0.2	0.6	1.2
Impedance of arm (left)	0.1	0.4	0.9	0.8	0.4	-0.6	0.7	0.3	0.9	0.1	-0.5	-1.0	0.3	0.7
Arm fat mass (right)	0.9	3.6	6.1	-0.9	-2.4	-0.4	-2.5	-2.1	-1.8	-2.0	-0.3	2.2	-2.4	-2.1
Trunk predicted mass	0.0	0.2	0.6	-0.1	-0.3	-0.5	0.1	-0.2	-0.7	-0.2	-0.0	0.6	0.1	-0.6
Standing height	0.0	0.3	1.3	-0.2	0.2	-1.1	0.3	0.2	-0.4	0.2	-0.1	0.6	1.1	0.1
Length of working week for main job	0.4	0.4	1.4	0.4	-0.7	-0.2	-0.4	-0.1	0.7	-0.6	-0.7	1.2	0.6	-0.8
Exposure to tobacco smoke at home	0.8	0.9	2.1	-0.3	-0.7	-1.2	-1.2	-0.4	-0.8	-1.4	-1.2	-0.6	-1.1	-0.6
Breastfed as a baby	0.3	0.3	1.3	0.1	-0.5	-0.8	0.6	-0.2	-1.2	-0.3	-0.8	0.3	-0.0	-0.3
Tense / ‘highly strung’	5.8	9.6	17.0	2.2	3.6	2.9	2.6	3.4	3.8	4.1	2.6	-2.7	2.8	2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	4.8	1.2	1.7	1.9	2.2	1.7	1.9	1.7	1.8	-1.1	1.8	1.2
Hair/balding pattern: Pattern 4	0.9	2.2	4.6	1.8	1.8	1.2	1.7	1.3	0.3	1.5	1.0	-1.1	2.1	1.4
Birth weight of first child	1.7	3.0	9.9	0.4	1.9	1.9	1.3	1.9	3.2	1.5	1.4	-1.1	1.5	1.5
Peak expiratory flow (PEF)	0.1	0.1	0.5	0.3	0.4	-0.5	0.4	-0.1	-0.0	-0.2	0.1	-0.3	0.7	-0.1
Pulse wave reflection index	1.5	1.9	2.9	1.6	1.7	-0.3	1.6	1.5	0.8	1.5	-0.3	-1.4	1.6	1.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	0.3	0.6	0.2	1.2	1.1	0.7	1.2	0.5	-0.7	0.9	-0.5
Loud music exposure frequency	0.9	1.0	2.4	1.6	1.2	-0.1	1.4	0.1	-0.6	1.4	-0.4	-1.0	1.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	-0.3	-0.6	-0.1	-0.1	-0.8	-1.0	-0.6	-0.2	0.3	0.1	-0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.5	0.4	0.2	-0.3	0.3	-0.1	0.6	0.5	-0.2	0.5	1.2	-0.0
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.8	-0.2	0.1	1.0	-0.4	-0.9	-0.3	0.1	-0.7	-1.0	0.6
Medication: Paracetamol	0.7	1.2	2.7	-0.4	-1.0	-1.3	-0.9	-1.0	-1.1	-1.7	-1.4	0.2	-1.3	-0.9
Headache pain in last month	0.1	0.2	1.2	-0.7	0.1	-0.2	-0.1	-0.0	0.3	0.0	-0.5	-0.4	0.2	-1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.7	-0.7	0.0	-2.1	0.1	-0.2	-0.1	-0.9	-2.2	-1.2	-0.2	-0.4
Glaucoma (self-reported)	0.6	0.7	3.7	0.3	-0.4	-1.9	0.5	-0.1	0.3	-0.1	-1.8	-0.1	0.5	-0.6
Gout (self-reported)	2.4	3.3	6.4	-1.3	-2.5	-1.1	-1.6	-2.5	-1.8	-1.5	-0.8	2.0	-1.8	-2.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.7	0.0	1.1	0.1	1.3	1.4	1.4	-0.3	-0.4	-2.2	0.0	0.8
Medication: Amlodipine	0.6	0.8	3.7	-0.2	-1.4	-0.8	-0.4	-0.6	-0.8	0.2	-0.5	1.9	-0.4	-1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.4	-0.5	-1.0	-0.9	-1.6	-0.7	0.0	-1.4	-0.8	1.3	-0.1	-1.0
Birth weight	2.6	5.6	8.8	1.8	2.9	1.8	2.1	3.0	2.9	2.0	1.6	-2.5	1.8	2.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.3	-0.6	-0.2	-0.1	-1.2	-0.0	-0.7	0.8	-0.7	0.4	0.4	-0.4
High blood pressure (siblings)	1.2	1.8	4.2	0.3	1.2	1.6	2.1	1.1	1.8	1.1	1.9	-1.0	-0.1	0.7
Forced vital capacity (FVC), Best measure	0.2	0.6	1.5	-0.3	-0.6	-1.2	-0.3	-0.9	-1.2	-0.7	-0.5	0.8	0.4	-0.9
Body fat percentage	1.2	4.8	9.4	-1.2	-2.7	0.0	-2.9	-2.3	-2.1	-2.5	0.0	2.4	-3.1	-2.0
Leg fat percentage (right)	1.3	4.6	8.1	-1.4	-2.5	-0.4	-2.7	-2.2	-2.9	-2.2	-0.4	1.9	-2.7	-2.4
Arm fat-free mass (right)	0.2	0.8	1.9	-1.1	-0.8	-0.5	-0.9	-0.7	-1.4	-0.6	0.1	1.3	-0.5	-0.9
Exposure to tobacco smoke outside home	1.8	2.4	3.6	-1.6	-1.9	-1.2	-1.7	-1.5	-1.8	-1.7	-1.2	1.1	-1.3	-1.8
Comparative body size at age 10	0.4	1.1	3.2	0.2	1.2	0.5	0.6	1.6	0.7	1.8	0.4	-0.3	1.7	1.0
Number of full brothers	0.6	0.7	2.2	1.0	1.1	-0.1	0.7	0.8	0.3	1.0	-0.5	-1.5	0.5	0.7
Worry too long after embarrassment	0.7	1.2	4.9	0.1	0.0	-1.3	0.8	-0.0	-1.5	0.7	-2.2	-1.0	0.8	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	6.2	0.4	1.7	1.0	2.5	1.3	0.9	1.8	0.9	-1.4	1.7	1.0
Wheeze or whistling in the chest in last year	0.1	0.2	1.1	-1.1	0.3	0.3	-0.9	0.3	0.1	-0.3	0.4	-0.1	-0.0	0.5
Number of children fathered	0.8	0.9	4.8	-0.8	-0.5	0.9	-2.2	-0.8	-0.4	-0.8	0.8	1.1	-0.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.9	0.1	-0.3	-1.4	-0.0	0.3	0.6	-0.2	-1.1	-0.9	-0.9	-0.6
Age at first live birth	1.8	3.2	7.0	1.0	2.0	0.7	1.5	2.6	2.4	2.1	0.6	-2.1	1.4	1.8
Pulse wave peak to peak time	0.2	0.3	1.1	-0.7	-0.8	0.2	0.3	-0.4	0.2	-0.0	0.1	0.1	-0.5	-1.0
Health satisfaction	0.6	0.8	2.6	-1.6	-1.1	-0.5	-0.3	-0.9	0.1	-1.0	-0.4	1.1	-0.7	-1.0
Shortness of breath walking on level ground	0.3	0.4	1.6	-0.7	0.5	0.2	-0.7	0.5	0.5	0.6	0.3	0.1	0.5	1.3
Qualifications: College or University degree	1.4	4.5	9.5	1.8	1.9	2.6	2.9	1.7	3.1	1.4	2.3	-0.8	1.3	2.3
Eye problems/disorders: None of the above	1.1	1.2	4.1	1.0	0.0	-0.6	0.6	-0.3	-0.9	-1.7	-0.7	-2.0	-1.8	0.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	5.6	0.1	-1.7	-0.4	-1.0	-1.6	-0.7	-2.4	-0.5	0.7	-2.2	-1.4
Emphysema/chronic bronchitis	0.4	0.4	1.6	-1.3	-0.0	-0.6	-0.3	0.9	0.6	0.6	-0.7	-0.5	-0.1	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	-0.5	-0.8	0.0	0.2	-0.5	-0.4	-0.4	0.0	0.0	-0.8	-0.5
Neck or shoulder pain in last month	0.2	0.3	1.2	-0.3	-0.3	0.6	0.7	-0.6	-0.3	-0.4	0.5	-0.3	-1.1	0.2
Medication: Blood pressure	0.3	0.5	1.8	0.2	-0.3	0.9	-0.4	0.0	-0.8	0.8	1.2	1.3	0.1	-0.0
Angina (self-reported)	1.0	1.4	3.0	1.4	0.9	1.7	0.3	0.9	1.1	0.9	1.5	0.2	1.4	1.4
Migraine (self-reported)	0.2	0.2	1.2	0.2	-0.1	0.0	-0.2	-0.0	-0.1	1.1	-0.1	0.8	0.5	-0.4
Medication: Ibuprofen	0.1	0.1	0.3	0.6	0.1	0.2	0.4	-0.1	-0.4	-0.2	0.5	0.5	0.2	0.1
Medication: Allopurinol	2.4	3.2	7.1	-1.1	-2.0	-2.0	-1.3	-2.1	-2.7	-1.3	-1.9	0.6	-1.5	-2.3
Medication: Omeprazole	0.7	0.8	4.5	0.6	0.6	0.1	1.3	-0.1	-0.8	0.0	-0.5	-2.1	-0.9	0.8
Medication: Seretide 50 evohaler	0.6	0.6	1.3	0.5	-0.7	1.0	-0.2	-0.8	-0.7	-1.0	0.9	1.2	-0.0	-1.1
Mean time to correctly identify matches	0.4	0.8	3.9	2.0	-0.5	0.9	0.8	-0.2	0.4	-0.8	0.3	-0.4	-1.4	0.5
Heart disease (mother)	0.0	0.1	0.3	-0.0	0.2	0.0	0.2	-0.3	-0.0	-0.2	0.3	-0.1	0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.1	7.9	-0.9	-2.2	-2.8	-0.5	-1.8	-2.0	-2.6	-2.6	-0.3	-2.6	-2.0
Whole body fat mass	1.2	5.0	8.6	-1.3	-2.8	-0.4	-2.9	-2.3	-2.2	-2.7	-0.2	2.6	-2.9	-2.3
Leg fat mass (right)	1.1	4.4	7.4	-1.2	-2.6	-0.5	-2.7	-2.1	-2.4	-2.2	-0.3	2.5	-2.4	-2.5
Arm predicted mass (right)	0.1	0.7	2.0	-0.8	-0.7	-0.4	-1.0	-0.6	-1.3	-0.5	0.2	1.4	-0.4	-0.7
Pulse rate, automated reading	1.7	5.5	10.9	-1.5	-3.0	-1.3	-1.6	-3.0	-1.9	-3.3	-0.9	1.8	-2.8	-3.1
Alcohol intake frequency.	0.6	1.4	3.3	-0.1	-1.4	-1.6	-1.5	-0.9	-0.8	-1.1	-1.8	0.8	-0.9	-1.4
Comparative height size at age 10	0.1	0.3	1.1	-0.7	-0.2	-1.1	0.9	-0.5	-0.3	0.5	-0.4	0.0	0.4	-0.1
Number of full sisters	1.2	1.4	4.7	-0.7	-0.9	-2.2	-0.0	-0.6	-0.2	-1.3	-1.9	-0.3	-1.1	-1.6
Suffer from ‘nerves’	2.5	3.9	10.7	1.1	2.6	0.4	1.0	2.6	2.0	3.3	0.0	-2.1	2.6	1.1
Overall health rating	0.5	1.1	2.0	-1.1	-0.7	-1.4	-1.0	-1.1	-1.0	-1.0	-1.2	-0.2	-0.6	-1.4
Chest pain or discomfort	0.3	0.4	1.1	-0.6	0.6	0.2	-0.6	0.4	0.0	0.7	0.1	-0.5	1.0	1.0
Had major operations	0.5	0.6	1.5	1.1	0.4	-0.0	1.2	0.3	-1.0	0.8	0.0	-1.1	-0.4	0.5
Age at last live birth	1.6	2.4	5.3	1.4	1.5	0.4	2.2	2.1	1.8	1.4	0.4	-2.3	1.0	1.2
Family relationship satisfaction	0.9	1.1	2.5	-0.6	1.6	0.7	0.6	1.4	1.1	0.7	0.6	-1.4	1.2	0.8
Leg pain on walking	0.6	0.8	4.6	-2.1	-0.4	0.1	-0.7	-0.4	-0.3	-1.0	0.0	-0.3	-1.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	3.3	4.0	8.4	-1.2	-2.8	-0.3	-1.5	-2.9	-2.9	-1.5	-0.6	2.4	-1.8	-2.1
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.6	-1.1	0.4	-0.9	-1.0	0.3	1.3	-0.0	-0.7	0.2	0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	0.8	-0.5	0.8	-0.4	-0.0	-0.1	0.1	0.6	0.5	-1.1	0.4
Medication: Aspirin	0.7	0.9	2.2	0.1	0.6	1.0	-1.5	0.5	0.4	0.9	0.8	1.4	1.4	0.8
Supplements: Vitamin C	1.7	2.0	6.6	0.7	1.9	1.5	0.9	0.9	1.0	1.1	1.5	-1.6	0.8	2.6
Knee pain experienced in last month	0.2	0.4	1.4	1.0	-0.4	-0.3	-0.2	-0.0	-0.9	-0.8	0.1	-0.3	-1.2	-0.2
Hypertension (Self-reported)	0.2	0.7	3.2	0.2	-0.8	0.1	0.5	-1.0	-1.0	-0.3	0.5	-0.3	-1.8	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	7.5	1.6	1.8	1.5	1.0	2.0	1.4	2.7	1.1	-0.7	2.5	1.2
Illnesses of father: Heart disease	4.3	5.9	11.9	-0.6	2.6	3.0	1.5	2.9	2.1	3.4	3.1	0.3	3.2	1.7
Illnesses of siblings: Diabetes	4.6	5.6	9.3	-1.5	-2.9	-1.6	-2.3	-2.5	-2.8	-3.0	-1.7	2.0	-2.7	-2.4
Smoking status: Previous	0.2	0.3	1.3	0.1	-0.3	-0.1	-1.1	0.0	-0.8	0.4	-0.2	0.7	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	3.5	-0.7	-0.1	-1.9	-0.2	-0.4	0.0	-0.0	-1.2	0.3	0.6	-0.7
Whole body fat-free mass	0.0	0.2	1.1	-0.0	-0.6	-0.3	-0.4	-0.3	-0.5	-0.4	0.2	1.1	-0.2	-0.7
Leg fat-free mass (right)	0.1	0.5	2.2	0.1	-0.9	-0.5	-1.0	-0.4	-0.3	-0.6	-0.1	1.5	-0.3	-0.8
Arm fat percentage (left)	0.8	3.3	7.5	-0.6	-2.4	-0.2	-2.0	-2.1	-1.7	-2.2	-0.2	1.7	-2.7	-2.0
Average weekly red wine intake	0.3	0.5	1.1	0.5	0.0	0.9	0.9	-0.4	-0.2	-0.5	1.0	-0.9	-1.0	0.1
Handedness (chirality/laterality): Left-handed	1.7	2.1	5.1	1.7	1.1	0.8	2.1	1.8	2.2	1.4	1.1	-0.4	1.2	0.7
Mood swings	0.5	0.9	2.6	-1.0	1.1	0.7	0.6	1.6	0.4	1.0	1.1	-0.5	0.8	0.8
Loneliness, isolation	1.2	1.6	3.5	-0.3	1.6	-0.9	0.7	1.4	0.3	1.9	-1.2	-1.8	1.8	0.5
Long-standing illness, disability or infirmity	0.9	1.3	6.3	-0.2	1.2	0.0	0.8	0.9	0.7	2.5	0.2	-0.5	1.9	1.1
Ever had bowel cancer screening	0.7	0.9	4.0	0.8	-0.2	1.2	-0.3	-0.4	0.2	-0.1	1.4	2.0	0.9	-0.4
Diabetes diagnosed by doctor	5.0	8.3	12.3	-3.4	-3.4	-2.5	-3.5	-3.3	-2.8	-2.0	-2.6	3.0	-1.7	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.4	0.3	-0.1	-1.6	0.1	-0.4	-0.5	-0.5	-1.4	-1.1	-0.1	-0.2
Friendships satisfaction	1.9	2.4	5.4	1.3	1.7	0.9	1.9	1.8	1.8	1.9	1.0	-0.7	2.3	0.5
Qualifications: nursing, teaching	1.3	2.0	6.6	1.2	1.0	2.3	2.0	0.6	1.3	0.5	2.6	-0.4	0.1	1.1
Commuting to job workplace: Walk	2.2	2.4	4.8	-1.0	-2.1	-1.5	-1.6	-2.2	-1.2	-0.8	-1.2	1.5	-1.4	-1.9
Eye problems/disorders: Cataract	0.4	0.5	1.8	-0.7	-0.4	0.4	-0.5	0.1	0.3	0.8	0.3	1.4	0.9	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.8	-0.7	0.5	0.5	-0.4	0.3	-0.2	0.1	0.8	0.2	-0.8
Medication for cholesterol	1.1	1.7	5.4	2.3	1.3	1.7	1.1	1.2	0.9	1.0	1.3	-0.7	1.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	0.1	0.5	-1.2	-0.9	0.5	-0.1	0.6	-1.0	-0.1	0.4	-0.2
Back pain experienced in last month	1.1	1.6	4.7	-0.1	1.5	1.0	0.4	2.2	0.6	1.6	1.5	-0.5	1.1	1.7
Mineral and other dietary supplements	1.1	1.5	8.2	-1.5	-0.8	0.1	-1.9	-0.5	0.2	-0.4	0.2	2.9	0.6	-0.8
Breast cancer (self-reported)	1.2	1.5	6.4	0.3	0.5	2.5	-0.7	0.9	0.5	0.6	2.2	1.0	0.3	1.2
Asthma (self-reported)	1.5	2.9	6.6	0.8	2.2	1.1	0.1	2.5	2.0	2.1	1.3	-0.4	2.6	1.7
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.7	0.6	0.0	0.7	0.8	0.8	0.2	0.0	-1.4	-0.0	1.4
Osteoarthritis (self-reported)	0.8	1.0	3.4	-0.9	-1.0	-0.3	-0.1	-1.3	-1.3	-1.3	-0.3	-0.3	-1.8	-0.8
Medication: Aspirin	0.4	0.6	3.2	-0.0	-0.0	0.4	-1.8	-0.2	-0.3	0.4	0.2	1.5	0.8	0.1
Medication: Gliclazide	5.7	6.5	14.7	-2.1	-2.3	-3.3	-2.8	-2.7	-2.4	-1.6	-3.8	2.3	-0.2	-2.8
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.3	-0.2	-0.1	-0.5	-0.3	-0.2	0.1	0.1	0.6	0.6	0.6
Smoking status: Current	4.3	6.8	14.7	-2.4	-2.8	-1.3	-2.3	-3.1	-3.3	-3.8	-1.4	1.5	-3.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.8	0.2	-1.0	-0.4	0.9	-1.1	-1.3	-1.2	-0.0	0.4	-0.8	-1.1
Whole body water mass	0.0	0.2	1.0	-0.0	-0.5	-0.3	-0.4	-0.3	-0.5	-0.3	0.1	1.0	-0.2	-0.7
Leg predicted mass (right)	0.1	0.6	2.4	0.0	-1.0	-0.5	-1.1	-0.4	-0.3	-0.7	-0.1	1.5	-0.4	-0.8
Arm fat mass (left)	0.8	3.4	5.7	-0.9	-2.4	-0.2	-2.2	-2.1	-1.7	-2.0	-0.1	2.2	-2.4	-2.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.5	-0.0	0.1	0.2	0.4	0.3	-0.1	0.7	0.0	-0.6	-0.4	-0.1
Average weekly champagne plus white wine intake	1.6	2.3	3.3	1.8	1.6	1.6	1.6	1.8	1.1	1.3	1.7	-1.0	1.1	1.6
Miserableness	0.8	1.3	4.2	0.6	1.4	0.8	2.0	1.1	1.2	0.6	0.5	-1.8	0.7	0.8
Guilty feelings	0.9	1.3	7.2	0.4	1.4	-0.2	1.5	0.9	-0.2	1.0	-0.6	-2.7	0.7	0.6
Wears glasses or contact lenses	5.6	6.5	15.3	-0.2	3.1	1.5	1.1	3.5	3.1	3.9	1.6	-0.5	3.7	2.2
Ever taken oral contraceptive pill	0.4	0.5	2.7	-0.4	-0.4	0.1	-1.2	-0.0	-0.6	0.2	0.3	1.6	0.5	-0.3
Hearing aid user	1.8	2.0	4.8	0.3	1.8	1.2	-0.3	2.0	1.3	1.6	1.0	-0.5	1.6	2.2
Mother’s age at death	1.2	1.5	4.9	0.1	1.1	2.2	0.2	0.9	1.1	1.0	2.2	0.2	0.7	1.4
Financial situation satisfaction	1.4	1.7	5.8	-0.3	-1.5	-1.2	0.0	-1.8	-1.1	-1.2	-1.1	0.8	-1.0	-2.4
Tinnitus: Yes, now most or all of the time	4.0	4.6	9.3	1.8	2.2	2.4	2.6	2.1	3.0	1.8	2.2	-1.1	2.1	1.8
Commuting to job workplace: Public transport	0.8	1.0	2.3	1.4	0.8	1.5	0.9	1.2	0.1	0.8	1.2	-0.9	0.2	0.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	0.1	0.0	-1.2	0.4	0.6	1.0	0.5	-1.2	0.4	1.3	-0.0
Medication: Blood pressure	0.7	1.3	3.6	-1.4	-1.2	-0.6	-1.2	-1.9	-0.9	-1.1	-0.4	0.4	-1.6	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	4.2	-0.0	-1.0	0.3	-0.4	-0.2	-0.4	-0.5	0.6	0.4	-2.0	-0.3
Supplements: Fish oil (including cod liver oil)	1.1	1.5	7.8	1.2	0.9	-0.4	1.6	1.0	-0.7	0.5	-0.5	-2.8	-0.7	1.1
High cholesterol (Self-reported)	0.5	0.9	2.2	-1.5	-1.1	0.9	0.2	-1.2	-0.2	0.1	1.2	1.0	-0.9	-0.8
Medication: Bendroflumethiazide	0.6	0.9	2.7	-0.8	-1.0	-0.1	0.3	-1.5	-1.6	-0.7	-0.4	0.1	-1.4	-0.8
Medication: Paracetamol	0.9	1.4	2.6	-1.0	-1.2	-0.9	-1.3	-1.6	-1.2	-1.6	-1.0	0.6	-1.6	-0.8
Medication: Lisinopril	0.7	0.9	2.6	-1.0	-0.7	-0.2	-1.6	-0.9	-1.3	-0.3	0.3	1.6	-0.1	-0.6
Medication: Atorvastatin	0.6	0.7	3.0	0.9	-0.2	1.7	0.6	-0.3	0.6	0.1	1.7	0.5	-0.4	0.1
Illnesses of father: High blood pressure	0.5	0.6	3.1	-0.6	-0.1	-1.8	0.4	-0.1	-0.4	0.3	-1.4	-0.5	0.4	-0.9
Alcohol drinker status: Never	2.4	2.9	5.8	-1.5	-1.9	-1.8	-2.4	-1.8	-1.6	-1.6	-1.6	1.4	-1.6	-1.4
Ever smoked	1.0	1.7	3.9	-0.2	-1.6	0.8	-1.6	-1.1	-1.4	-1.3	0.9	1.8	-2.0	-0.5
Basal metabolic rate	0.1	0.7	1.8	-0.3	-1.0	-0.6	-1.0	-0.8	-1.1	-0.8	-0.1	1.4	-0.6	-1.1
Leg fat percentage (left)	1.6	5.9	9.6	-1.9	-2.8	-0.6	-3.1	-2.5	-3.1	-2.6	-0.5	2.4	-3.0	-2.5
Arm fat-free mass (left)	0.2	1.0	2.7	-1.0	-1.1	-0.3	-1.3	-0.8	-1.1	-0.8	0.2	1.7	-0.6	-1.1
Number of operations (self-reported)	0.3	0.4	1.0	0.2	0.7	0.0	0.4	0.9	0.4	1.0	0.2	-1.0	-0.4	0.9
Average weekly beer plus cider intake	1.3	1.9	6.5	-1.6	-0.9	-2.4	-1.8	-1.0	-0.5	-0.6	-2.5	0.2	-0.2	-0.8
Irritability	0.2	0.4	1.2	-0.3	0.8	0.7	-0.1	1.1	0.7	0.6	0.7	-0.2	0.5	0.4
Risk taking	0.6	0.9	3.6	0.4	0.5	1.9	-0.4	0.6	-0.5	-0.5	1.7	0.2	-0.4	1.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.9	1.5	1.3	0.0	2.2	1.2	0.3	1.7	0.1	-1.2	0.8	0.9
Fractured/broken bones in last 5 years	1.7	2.2	4.2	1.5	1.1	2.1	1.7	1.7	1.8	1.2	1.9	-1.1	0.3	0.9
Age started oral contraceptive pill	1.3	1.6	6.1	-0.8	0.1	2.1	-1.0	0.3	1.5	0.3	2.5	1.5	0.3	0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.9	0.4	1.0	-0.2	-0.0	0.8	-0.3	0.3	0.3	-0.6	0.8	0.7
Ever depressed for a whole week	0.2	0.2	1.1	-0.0	-0.4	0.1	0.2	0.3	0.8	-0.4	0.4	0.6	-0.0	-1.1
Unable to work because of sickness or disability	1.0	1.2	3.2	-0.2	-1.3	-1.5	-1.0	-1.0	-0.7	-0.2	-1.3	1.8	0.2	-1.4
Commuting to job workplace: Cycle	0.9	1.1	2.9	-0.2	1.4	0.5	1.1	0.7	0.7	1.7	0.4	-0.8	1.7	0.9
Myopia	0.3	0.4	1.6	0.6	-0.2	-0.8	0.1	-0.4	-0.6	-0.7	-1.2	-0.6	-0.3	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.2	-0.1	0.6	-0.3	-0.0	0.8	0.7	0.1	-0.6	-0.1	1.1	0.8
Cholesterol lowering medication	0.5	0.8	2.6	-1.6	-1.0	-0.3	-0.6	-1.0	-0.9	-0.7	0.2	0.6	-1.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	3.7	0.5	0.7	0.3	0.8	0.0	-0.5	0.6	-0.2	-1.9	-0.5	0.9
Pain experienced in last month	0.5	0.9	3.3	-0.5	-0.6	-1.6	-1.2	-0.8	-0.5	-0.6	-1.8	0.7	0.3	-0.6
Supplements: Calcium	0.6	0.6	2.3	0.9	0.6	0.7	0.5	0.5	1.0	-0.3	0.2	-1.1	-0.0	1.5
Basal cell carcinoma (self-reported)	0.3	0.3	1.2	-1.1	-0.1	0.1	-0.6	-0.3	0.2	0.5	0.2	0.9	0.8	-0.3
Heart attack/myocardial infarction (self-reported)	1.5	2.0	4.4	0.6	2.1	0.6	0.4	2.0	1.2	1.9	0.6	-1.3	1.8	1.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	-0.5	-0.2	0.1	1.1	-0.5	-0.9	-0.4	0.2	-1.0	-1.1	0.6
Heart disease (siblings)	2.1	2.5	5.6	1.1	2.0	-0.6	1.3	2.4	0.9	2.3	-0.5	-1.2	2.0	1.8
Alcohol drinker status: Previous	1.8	2.0	3.8	-1.8	-1.4	-1.7	-1.7	-0.9	-1.4	-0.9	-1.7	0.8	-0.7	-1.9
Pack years of smoking	0.2	0.3	1.4	0.3	-0.5	0.1	-1.2	-0.2	0.5	0.0	0.0	0.8	-0.5	-0.4
Impedance of whole body	0.0	0.1	0.4	-0.3	-0.1	-0.6	-0.1	-0.2	0.1	-0.4	-0.5	-0.3	-0.0	0.3
Leg fat mass (left)	1.3	5.2	8.8	-1.5	-2.8	-0.7	-3.0	-2.4	-2.5	-2.4	-0.5	2.8	-2.5	-2.5
Arm predicted mass (left)	0.2	0.8	2.4	-1.0	-0.9	-0.3	-1.2	-0.6	-1.2	-0.7	0.3	1.6	-0.5	-1.0