TWAS hub - SLC40A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3220	0.0590	0.0e+00	0.189	0.193	0.234	0.214	0.225	1.7e-22	6.1e-23	4.6e-28	1.5e-25	6.6e-27
2	GTEx	Thyroid	0.1110	0.0420	6.5e-04	0.123	NA	0.112	NA	0.114	1.1e-09	NA	7.0e-09	NA	5.1e-09
3	METSIM	Adipose	0.0713	0.0267	2.0e-04	0.019	0.021	0.026	0.027	0.027	6.3e-04	3.3e-04	7.5e-05	5.7e-05	4.9e-05
4	NTR	Blood	0.0132	0.0064	5.7e-03	0.010	0.006	0.010	0.006	0.012	2.9e-04	3.3e-03	2.1e-04	4.7e-03	6.2e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.0840	0.0245	3.4e-08	0.111	0.074	0.093	0.084	0.100	3.9e-14	9.7e-10	5.5e-12	5.8e-11	7.8e-13
6	YFS	Blood	0.2106	0.0378	0.0e+00	0.103	0.158	0.168	0.158	0.159	8.0e-32	2.5e-49	1.6e-52	2.2e-49	1.9e-49

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Seretide 50 evohaler	4.4	5.1	7.7	-2.8	-2.5	-1.7	-1.7	-2.6	-2.0
Alcohol drinker status: Previous	4.2	4.8	10.0	3.2	2.8	0.6	1.6	2.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.7	6.9	2.1	2.1	1.2	2.6	2.4	2.2
Shortness of breath walking on level ground	3.8	4.5	5.8	2.2	2.0	1.6	2.3	2.4	2.2
Smoking Status	3.4	8.1	10.7	3.2	2.9	3.3	2.2	3.2	2.2
Breast Cancer	3.3	7.9	13.8	3.0	2.2	2.2	2.8	2.7	3.7
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	8.0	2.1	2.7	-0.0	2.5	2.8	1.6
Eye problems/disorders: Glaucoma	3.0	3.6	6.7	2.5	1.4	0.2	1.5	2.1	2.6
Number of full brothers	2.9	3.7	6.0	2.3	0.9	2.4	1.6	1.8	2.1
Blood Red Count	2.8	26.7	40.4	-3.7	-6.2	-0.9	-6.4	-5.7	-5.8
Frequency of depressed mood in last 2 weeks	2.7	3.8	6.0	2.4	1.6	2.1	1.5	2.4	1.3
Commuting to job workplace: Car/motor vehicle	2.6	3.0	5.0	2.2	2.0	1.0	1.4	1.9	1.6
Length of working week for main job	2.5	2.7	4.7	1.1	1.4	1.7	1.9	2.2	1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.5	3.0	6.3	1.6	1.2	2.5	1.5	1.8	1.4
Neuroticism (2016)	2.4	3.4	6.5	1.8	1.7	2.6	0.8	1.9	1.9
Supplements: Zinc	2.4	2.6	4.2	1.6	1.0	1.1	2.0	2.0	1.7
Fed-up feelings	2.4	4.3	7.8	2.8	1.1	1.8	2.1	2.2	2.0
Eye problems/disorders: None of the above	2.4	2.8	5.7	-2.0	-2.4	-0.5	-0.6	-1.9	-1.6
Mood swings	2.4	4.4	6.5	2.3	2.3	2.0	1.8	2.6	1.5
Smoking status: Current	2.4	3.8	4.4	2.0	2.1	1.9	2.0	2.0	1.7
Primary Biliary Cirrhosis	2.3	3.2	4.0	1.9	0.8	1.9	2.0	1.9	2.0
Alcohol usually taken with meals	2.3	3.7	5.8	-2.3	-2.1	-1.1	-2.0	-2.4	-1.1
Tense / ‘highly strung’	2.2	3.7	8.1	1.7	1.5	1.1	2.8	2.0	1.9
Chronic bronchitis/emphysema (mother)	2.2	2.5	3.7	1.9	0.9	1.4	1.8	1.6	1.7
Heart disease (mother)	2.2	2.6	6.2	-1.6	-2.5	-0.6	-1.4	-1.8	-1.2
Schizophrenia vs Biploar Disorder	2.1	2.7	5.6	1.4	2.4	0.8	1.7	1.8	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.1	1.6	1.7	0.2	1.9	2.0	1.4
Current tobacco smoking	2.0	3.3	4.6	1.7	2.1	1.7	1.9	2.0	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	5.5	2.3	1.0	2.2	0.7	1.8	1.0
Medication: Ramipril	2.0	2.5	3.7	1.8	1.3	1.8	1.6	1.9	0.9
Had major operations	2.0	2.4	5.9	-0.7	0.3	-2.4	-2.0	-0.7	-1.8
Systolic Blood Pressure	1.9	9.6	15.2	3.0	2.5	2.1	3.7	3.9	3.0
Alcohol intake versus 10 years previously	1.9	2.9	5.3	1.5	1.5	0.2	2.3	1.5	2.2
Number of operations (self-reported)	1.9	2.9	5.7	1.6	2.4	0.4	1.1	2.0	1.9
Bipolar Disorder (2011)	1.8	1.8	3.0	-1.3	-1.2	-0.4	-1.2	-1.7	-1.7
Hearing aid user	1.8	2.0	5.9	-0.3	-2.4	-0.7	-1.1	-1.2	-1.7
Cardiovascular Disease	1.7	5.5	8.1	2.2	2.5	2.3	2.3	2.8	1.9
Medication: Metformin	1.7	2.4	3.9	1.9	1.3	1.3	1.4	2.0	1.3
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	6.3	0.8	0.5	0.9	2.2	1.1	2.5
Ever had bowel cancer screening	1.7	2.0	4.3	-0.7	-0.3	-2.1	-2.0	-0.8	-1.6
Medication: Aspirin	1.7	2.2	3.4	1.4	1.4	0.6	1.8	1.6	1.8
Miserableness	1.7	3.0	6.1	2.5	1.9	0.6	1.4	1.8	1.6
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.3	-2.1	-1.2	-1.7	-1.1	-1.2	-1.3
Alzheimer’s Disease (in mother)	1.6	1.9	4.6	0.5	2.1	-0.8	1.7	1.5	0.9
Fluid intelligence score	1.6	3.4	6.9	-2.6	-2.4	-1.2	-1.3	-1.7	-1.2
Noisy workplace	1.6	2.0	4.7	2.2	0.2	1.8	0.9	1.1	1.4
Birth weight of first child	1.6	2.9	6.5	-1.5	-0.1	-2.5	-1.3	-1.3	-2.4
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	6.1	-1.7	-2.5	-0.6	-1.5	-1.6	-0.9
Commuting to job workplace: Walk	1.6	1.8	4.5	-1.2	-2.1	1.0	-1.5	-1.1	-0.6
Hand grip strength (right)	1.5	4.0	8.2	2.1	0.8	1.7	2.3	1.6	2.9
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.3	1.4	1.8	1.1	0.9	1.6	0.8
Glaucoma (self-reported)	1.5	1.8	4.1	2.0	0.7	0.4	1.0	1.4	1.8
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.9	1.7	1.5	0.0	1.4	1.4	1.7
Neck or shoulder pain in last month	1.5	2.1	3.7	-1.0	-1.2	-1.0	-1.8	-1.5	-1.9
Alcohol intake frequency.	1.5	3.4	6.0	2.2	2.4	0.2	1.4	2.2	1.7
Family relationship satisfaction	1.5	1.9	3.7	1.2	0.8	0.6	1.9	1.6	1.7
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.4	-1.6	-1.2	-1.9	-1.1	-1.4	-0.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.2	1.8	0.5	1.1	1.5	1.0	1.3
Time employed in main current job	1.4	1.6	2.7	-1.5	-0.6	-1.5	-1.3	-1.6	-0.9
Asthma	1.4	2.7	6.6	1.2	2.6	1.0	1.4	2.1	0.9
Osteoporosis (self-reported)	1.4	1.8	3.5	-1.0	-1.0	-1.1	-1.9	-1.0	-1.7
Illnesses of father: High blood pressure	1.4	1.7	3.4	0.7	1.2	1.2	1.3	1.8	1.5
Alzheimer’s Disease (including proxy)	1.3	2.0	4.3	1.0	2.1	-1.1	1.3	1.4	1.2
Coronary Artery Disease (CAD)	1.3	1.5	3.4	1.3	0.4	0.2	1.4	1.4	1.8
Fasting Glucose	1.3	1.6	3.5	1.5	-0.5	0.8	1.9	0.6	1.6
Sitting height	1.3	9.1	17.8	-4.2	-2.3	0.9	-3.3	-3.0	-3.3
Forced vital capacity (FVC)	1.3	5.1	6.9	-2.2	-2.6	-0.3	-2.4	-2.4	-2.6
Gout (self-reported)	1.3	1.8	3.0	1.3	1.7	0.3	1.5	1.4	1.4
Number of full sisters	1.3	1.6	2.7	1.1	1.7	-0.5	1.3	1.6	1.0
Medication: Aspirin	1.3	1.8	3.1	1.3	1.0	0.5	1.8	1.3	1.7
Asthma (self-reported)	1.3	2.7	6.8	1.2	2.6	0.8	1.4	2.1	0.9
Alcohol drinker status: Never	1.3	1.5	3.8	-0.9	-2.0	-0.7	-1.3	-1.5	-0.4
Irritability	1.3	2.2	4.4	2.1	1.1	1.4	1.4	1.5	1.3
Fractured/broken bones in last 5 years	1.3	1.6	3.7	1.2	1.9	0.1	1.2	1.7	0.4
Depression (Nagel 2018)	1.2	1.8	3.4	1.7	1.0	1.9	0.3	1.5	1.0
Had other major operations	1.2	1.4	2.6	0.4	1.6	1.2	1.2	1.2	1.2
Worry too long after embarrassment	1.2	2.0	3.6	1.4	1.7	0.8	1.6	1.9	0.3
Medication: Allopurinol	1.2	1.6	3.5	0.7	1.9	0.5	1.5	1.6	0.7
Osteoarthritis (self-reported)	1.2	1.5	3.5	-0.9	-0.8	-1.2	-1.4	-1.0	-1.9
Average weekly champagne plus white wine intake	1.2	1.6	2.9	-1.0	-1.7	-0.5	-1.7	-1.6	-0.7
Mother’s age at death	1.2	1.5	2.8	-0.4	-0.8	-1.7	-1.3	-1.3	-1.4
Financial situation satisfaction	1.2	1.5	3.3	1.8	1.1	0.8	1.1	1.4	0.8
Depressed Affect (Nagel 2018)	1.1	2.4	5.3	2.3	0.9	1.3	1.1	1.5	1.7
High blood pressure	1.1	3.0	5.5	1.7	2.4	0.9	1.5	2.2	1.3
Emphysema/chronic bronchitis	1.1	1.3	2.5	-1.6	-1.1	-0.6	-0.8	-1.4	-1.1
Number of self-reported non-cancer illnesses	1.1	2.0	4.7	1.1	1.7	1.0	1.2	2.2	0.8
Had menopause	1.0	1.3	3.1	-0.8	-0.3	-1.2	-1.1	-1.1	-1.8
Pain all over the body in last month	1.0	1.1	2.6	0.9	1.6	-1.1	-0.4	1.1	-0.7
Blood clot in the leg (DVT)	1.0	1.4	2.4	1.2	1.3	-0.2	1.1	1.5	1.1
Ever had prostate specific antigen (PSA) test	1.0	1.1	6.5	-0.5	-0.0	-2.6	-0.2	-0.1	-0.1
Vascular/heart problems diagnosed by doctor	1.0	2.8	4.0	-1.7	-1.9	-1.1	-1.6	-2.0	-1.5
Neuroticism (Nagel 2018)	0.9	2.1	3.0	1.7	1.0	1.1	1.6	1.5	1.6
Hand grip strength (left)	0.9	2.3	5.9	1.4	0.9	0.8	1.6	1.5	2.4
Hearing difficulty/problems: Yes	0.9	1.4	2.8	0.1	-1.7	-0.2	-1.6	-1.5	-0.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.8	-0.6	-0.2	-0.5	-1.6	-0.4	-1.7
Pack years adult smoking proportion	0.9	1.4	4.3	2.1	0.7	0.2	1.3	1.1	0.9
Average weekly fortified wine intake	0.9	1.1	2.2	0.3	-0.8	-1.1	-1.5	-1.1	-1.1
Past tobacco smoking	0.9	1.7	3.3	-1.8	-1.4	-1.4	-0.4	-1.3	-0.9
Neuroticism score	0.9	2.0	3.5	1.9	1.4	1.3	1.3	1.6	0.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	4.6	-1.8	-2.1	0.1	-1.7	-1.9	-1.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.9	-1.7	-1.0	-0.6	-1.2	-1.6	-1.0
High blood pressure (siblings)	0.9	1.3	6.1	0.6	-0.6	2.5	-0.0	0.3	0.8
Forced vital capacity (FVC), Best measure	0.9	3.3	5.2	-1.8	-2.3	0.2	-1.8	-1.9	-2.2
Exposure to tobacco smoke outside home	0.9	1.2	2.9	1.7	1.0	0.1	1.1	1.3	0.7
Hypertension (Self-reported)	0.9	2.5	5.4	1.5	2.3	0.6	1.2	2.1	1.1
Illnesses of father: Heart disease	0.9	1.2	2.9	-0.5	-1.7	0.9	-1.3	-1.3	-0.4
Qualifications: nursing, teaching	0.9	1.4	2.5	-1.6	-1.5	-0.0	-1.5	-1.1	-0.7
Ovarian Cancer	0.8	1.1	5.5	-0.4	0.5	-2.4	-0.4	-0.4	0.1
Sensitivity / hurt feelings	0.8	1.4	3.6	1.3	0.9	1.9	0.6	1.3	0.6
Systolic blood pressure, automated reading	0.8	2.3	3.9	1.3	0.9	1.3	1.8	2.0	1.5
Qualifications: CSEs or equivalent	0.8	1.1	2.5	0.5	0.7	1.6	1.2	1.3	-0.1
Serious illness, injury or assault to yourself	0.8	0.9	4.6	-0.2	0.7	-2.1	-0.5	0.3	-0.2
Falls in the last year	0.8	1.1	2.1	1.1	1.4	-0.4	0.8	1.2	1.1
Long-standing illness, disability or infirmity	0.8	1.3	2.3	0.9	1.3	0.3	0.8	1.4	1.5
Eye problems/disorders: Cataract	0.8	0.9	2.0	1.4	1.3	0.5	0.6	0.7	0.7
Wears glasses or contact lenses	0.8	1.0	3.2	0.7	1.8	0.7	0.8	0.9	0.5
Medication: Atorvastatin	0.8	0.9	1.8	1.3	0.3	-0.3	1.0	1.0	1.4
Ever depressed for a whole week	0.8	1.0	3.7	1.9	-0.4	0.9	-0.3	1.1	0.5
Schizophrenia (2018)	0.7	1.4	4.4	-0.5	-0.9	-2.1	-0.6	-1.0	-1.2
Age at First Birth	0.7	1.0	2.7	1.6	-0.5	1.6	-0.2	0.1	0.9
LDL Cholesterol	0.7	1.1	2.5	-0.2	1.4	-1.6	0.7	1.0	0.5
Lupus	0.7	1.1	2.0	-1.3	-1.3	-0.3	-1.4	-0.9	0.2
Ulcerative Colitis	0.7	1.0	1.7	1.3	0.8	-0.1	0.9	1.1	1.3
Medication: Co-codamol	0.7	0.8	2.6	0.1	1.6	-0.4	0.8	1.0	0.7
Hair/balding pattern: Pattern 2	0.7	0.9	2.7	-0.3	-0.9	0.5	-0.9	-0.9	-1.6
Financial difficulties in last 2 years	0.7	0.9	1.5	1.0	0.6	1.2	1.0	1.1	0.4
Depression (self-reported)	0.7	0.9	1.8	-0.3	-0.7	-0.7	-1.4	-0.7	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.8	-1.6	-1.8	-0.2	-1.4	-1.4	-1.9
Qualifications: College or University degree	0.7	2.2	5.9	-2.4	-1.5	-0.3	-1.2	-1.5	-1.3
Medication: Blood pressure	0.7	1.3	3.5	1.9	0.7	1.0	0.8	1.3	0.8
Smoking status: Previous	0.7	1.1	1.9	1.4	1.2	1.2	0.4	1.1	0.7
Illnesses of father: None of the above (group 1)	0.7	0.8	2.1	0.1	1.4	-1.3	0.9	0.7	0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.7	1.0	1.1	-0.1	0.9	1.3	0.9
Pack years of smoking	0.7	1.0	3.6	1.9	0.5	0.1	1.0	0.9	0.8
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.7	-1.3	-2.4	0.9	-1.3	-1.2	-0.7
Respiratory disease	0.6	1.3	5.1	0.2	2.2	0.2	0.9	1.3	0.2
Angina	0.6	0.8	2.0	1.3	-0.0	1.4	0.5	0.4	1.1
Multivitamins +/- minerals	0.6	0.8	1.9	1.0	-0.1	1.4	0.6	0.5	1.1
Illnesses of siblings	0.6	0.8	3.4	-0.1	-0.3	-1.9	-0.8	-0.7	-0.7
Worrier / anxious feelings	0.6	1.1	2.3	-1.2	-1.1	-1.5	-0.5	-1.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.8	1.2	-0.5	1.7	0.6	0.8	0.6
Happiness	0.6	0.7	3.5	0.7	-0.2	-1.9	0.6	0.3	0.2
Illnesses of mother	0.6	0.7	2.2	-0.0	-0.5	-1.5	-1.0	-0.8	-0.3
Standing height	0.6	5.5	11.4	-3.4	-1.8	1.4	-2.2	-2.1	-2.7
Hair/balding pattern: Pattern 4	0.6	1.4	3.5	1.2	-1.4	1.9	-0.6	0.3	1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	1.6	-1.2	-1.0	-0.4	-1.3	-1.2	-0.7
Angina (self-reported)	0.6	0.8	1.8	1.4	0.2	1.3	0.4	0.5	0.9
Leg pain on walking	0.6	0.7	1.4	-0.1	1.2	-1.0	-0.7	0.3	-1.1
Medication for cholesterol	0.6	1.0	3.6	-0.6	-1.9	-0.0	-0.8	-1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.6	-0.9	-0.9	-0.2	-0.9	-0.9	-2.1
Age started oral contraceptive pill	0.6	0.7	1.8	1.3	0.8	0.2	1.1	0.6	0.7
Heel T-Score	0.5	3.6	7.1	-1.6	-2.7	0.4	-2.2	-2.3	-1.3
Lung FVC	0.5	2.6	3.7	-1.5	-1.9	-0.7	-1.5	-1.9	-1.9
Neuroticism	0.5	1.2	2.2	1.5	1.0	0.6	1.3	1.4	0.4
Average weekly spirits intake	0.5	0.7	1.8	0.9	-0.4	1.3	0.7	0.2	0.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	0.5	-0.1	-1.2	0.0	-0.2	1.4
Vitamin and mineral supplements	0.5	0.7	1.6	-1.3	0.5	-1.2	0.0	-0.6	-0.6
Relative age voice broke	0.5	0.8	1.3	-0.2	-1.1	-1.1	-0.9	-1.1	-0.2
Hip circumference	0.5	2.3	4.2	-0.9	-1.5	0.5	-2.1	-1.4	-2.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.4	-1.5	-1.9	-0.3	-0.2	-0.8	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.9	1.7	1.2	0.1	1.3	1.1	0.5	1.0
Breastfed as a baby	0.5	0.6	1.0	-0.7	-0.9	-0.7	-0.9	-1.0	-0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	-1.0	-0.4	-1.1	-0.7	-0.6	-0.8
Pulse wave peak to peak time	0.5	0.6	1.4	-1.0	-1.2	0.2	-0.4	-0.3	-0.9
Health satisfaction	0.5	0.6	1.4	1.2	1.0	0.2	0.5	1.0	0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.3	0.1	-1.5	0.4	-0.2	-0.9	0.5
Medication: Omeprazole	0.5	0.6	1.3	1.1	0.5	0.3	0.9	0.9	0.7
Suffer from ‘nerves’	0.5	0.8	1.7	1.3	-0.7	1.1	0.8	0.5	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	-0.9	-0.4	-1.2	-1.0	-0.5	-1.2
Breast cancer (self-reported)	0.5	0.6	2.5	-0.2	0.4	1.6	-0.1	0.4	-0.9
Average weekly beer plus cider intake	0.5	0.7	2.0	1.4	0.9	0.6	0.3	0.8	-0.6
Diastolic blood pressure, automated reading	0.5	1.6	3.1	0.6	0.8	1.4	1.7	1.6	1.1
Bipolar Disorder or Schizophrenia	0.4	1.0	3.1	-0.1	-1.1	-1.8	-0.6	-0.9	-0.8
Worry (Nagel 2018)	0.4	0.8	1.7	1.0	0.3	0.4	1.1	0.8	1.3
Ulcerative Colitis (UC)	0.4	0.7	1.2	0.8	0.4	0.7	0.8	0.9	1.1
Reaction Time	0.4	0.7	2.4	-0.4	1.5	-0.5	0.6	0.8	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.5	-0.8	-1.9	0.1	-0.9	-0.9	-0.2
HbA1C	0.4	0.4	1.1	-0.6	-0.8	-1.0	-0.2	-0.6	-0.5
Triglycerides	0.4	0.6	2.5	0.0	0.8	-1.6	0.2	0.6	0.2
Waist Hip Ratio (WHR)	0.4	1.9	3.2	0.5	1.8	-0.6	1.6	1.5	1.6
Hypothyroidism (self reported)	0.4	0.9	2.3	-0.7	-1.4	1.5	-0.5	-0.7	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.7	-0.8	-0.1	-0.1	-1.3	-0.6	-1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.6	-0.3	-1.3	-0.8	0.0	-0.9	0.0
Townsend deprivation index at recruitment	0.4	0.5	1.0	0.4	0.8	-0.2	0.4	1.0	-1.0
Maternal smoking around birth	0.4	0.5	2.3	-0.5	1.5	-0.5	0.6	0.4	-0.1
High blood pressure (mother)	0.4	0.5	2.3	0.4	0.4	1.5	0.4	0.5	0.2
Nervous feelings	0.4	0.7	1.8	0.6	0.6	-0.1	1.4	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.5	1.0	-0.2	1.6	1.0	0.4	0.6
Qualifications: None of the above	0.4	0.8	1.7	1.2	1.3	0.0	1.0	0.6	0.2
Father’s age at death	0.4	0.5	0.9	-0.8	-0.6	-1.0	-0.7	-0.7	-0.5
Pulse rate	0.4	0.7	1.7	1.2	-0.9	1.3	-0.1	0.2	0.2
Medication: Paracetamol	0.4	0.6	1.1	0.4	1.0	-0.1	1.1	1.0	0.6
Birth weight	0.4	0.8	3.1	-1.8	0.4	-0.8	0.6	-0.6	-0.1
Migraine (self-reported)	0.4	0.5	2.4	-0.5	0.1	-1.6	-0.2	0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.1	-0.6	0.9	-0.9	-0.2	-1.1
Average weekly red wine intake	0.4	0.7	2.7	-0.4	1.0	-1.6	0.4	0.1	0.1
Ever taken oral contraceptive pill	0.4	0.5	1.8	0.2	-0.3	-1.3	-0.6	-0.6	0.2
Commuting to job workplace: Public transport	0.4	0.4	1.3	-0.5	-0.1	-1.1	0.7	-0.6	0.3
High cholesterol (Self-reported)	0.4	0.7	2.5	-0.2	1.6	-0.0	0.9	1.0	0.3
Medication: Paracetamol	0.4	0.6	1.5	0.2	1.2	-0.0	1.0	0.9	0.8
Ever smoked	0.4	0.6	2.3	1.5	0.3	0.9	-0.4	0.5	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.7	0.9	0.6	0.6	1.0	-0.1
Alzheimer’s Disease (in father)	0.3	0.4	1.6	0.6	-0.2	-1.2	-0.0	-0.4	0.2
Irritable Bowel Disease (IBD)	0.3	0.7	1.5	0.8	0.5	0.0	1.1	1.0	1.2
Crohns Disease (2012)	0.3	0.5	1.9	-0.5	0.6	-1.4	0.5	0.1	0.2
Height	0.3	6.3	12.8	-3.6	-2.0	0.9	-2.7	-2.4	-2.7
Chronotype (morning person)	0.3	0.8	2.4	-1.3	-0.3	-1.5	0.5	-0.4	0.1
Trunk fat percentage	0.3	1.2	3.8	0.6	-0.3	1.9	-1.0	-0.1	-1.5
Stomach or abdominal pain in last month	0.3	0.4	1.2	0.3	-0.9	1.1	-0.3	0.1	-0.4
Trunk fat mass	0.3	1.2	3.4	0.4	-0.4	1.9	-1.2	-0.3	-1.4
Number of incorrect matches in round	0.3	0.5	2.1	-0.0	-0.2	1.4	-0.2	-0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.6	1.2	-0.3	0.5	-0.2	0.6	-0.3
Medication: Simvastatin	0.3	0.5	2.5	-0.2	1.6	-0.2	0.4	0.5	-0.0
Impedance of arm (right)	0.3	1.3	6.1	-0.3	0.1	2.5	0.4	0.6	-0.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	0.7	1.0	-0.3	0.1	0.1	0.5
Exposure to tobacco smoke at home	0.3	0.3	0.8	0.2	-0.3	-0.3	0.8	0.3	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.9	1.4	-0.0	-0.2	-0.5	0.7	0.4
Pulse wave reflection index	0.3	0.4	1.2	0.1	1.1	-0.0	0.3	0.2	0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.0	1.4	0.0	-0.1	0.2	0.6	0.3
Loud music exposure frequency	0.3	0.3	0.6	0.2	-0.5	-0.8	-0.7	-0.2	-0.7
Number of children fathered	0.3	0.4	0.9	-0.3	-0.6	-0.9	-0.4	-0.8	0.2
Arm predicted mass (right)	0.3	1.6	2.9	-1.1	-1.6	0.1	-1.7	-1.4	-1.0
Pulse rate, automated reading	0.3	1.0	3.1	0.3	-1.1	1.8	-0.7	0.1	-1.1
Overall health rating	0.3	0.7	1.7	1.3	0.5	1.1	0.1	1.0	0.3
Chest pain or discomfort	0.3	0.4	1.0	1.0	0.6	0.5	0.4	0.9	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	-0.4	-0.5	-0.5	-0.6	-0.5	-1.1
Supplements: Vitamin C	0.3	0.3	1.0	1.0	0.0	-0.3	0.5	0.6	0.6
Knee pain experienced in last month	0.3	0.4	1.5	0.5	-0.4	1.2	-0.4	-0.2	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	1.0	0.7	0.5	0.1	0.8	0.4
Mineral and other dietary supplements	0.3	0.4	1.6	-0.2	0.6	-1.3	-0.5	-0.1	0.3
Medication: Bendroflumethiazide	0.3	0.4	1.6	0.5	-0.6	1.3	0.1	0.3	0.3
Medication: Lisinopril	0.3	0.4	1.3	0.5	1.2	-0.9	-0.4	0.2	0.1
Myopia	0.3	0.5	2.0	0.3	-0.2	1.4	-0.6	0.4	0.5
Cholesterol lowering medication	0.3	0.4	1.9	0.2	1.4	-0.0	0.3	0.4	0.0
Supplements: Calcium	0.3	0.3	0.8	-0.9	0.5	0.8	0.5	0.2	-0.1
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	0.1	0.1	0.4	0.6	0.7	1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	0.4	-0.8	0.1	0.5	-0.6	0.8
Heart disease (siblings)	0.3	0.3	1.3	-1.2	0.3	-0.4	0.4	-0.3	-0.4
Arm predicted mass (left)	0.3	1.3	2.3	-1.1	-1.1	-0.1	-1.5	-1.3	-1.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.5	-0.6	-0.4	-0.4	-0.5	-0.6
HDL Cholesterol	0.2	0.3	1.2	0.0	-0.2	1.1	-0.1	-0.1	-0.6
Rheumatoid Arthritis	0.2	0.2	0.7	-0.4	0.3	0.8	-0.5	-0.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.7	-0.2	-0.7	-0.2	-0.5	0.2
Relative age of first facial hair	0.2	0.4	0.8	-0.6	-0.4	-0.9	-0.1	-0.8	-0.3
Diabetes (father)	0.2	0.2	1.0	0.0	-0.4	1.0	-0.5	0.0	-0.2
Diabetes (mother)	0.2	0.2	0.6	0.0	0.5	0.8	0.6	0.3	0.1
Leg fat-free mass (left)	0.2	0.9	1.8	-0.2	-1.1	1.1	-1.3	-0.7	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.5	-0.1	0.5	-0.2	0.7	0.2
Supplements: Glucosamine	0.2	0.3	0.8	0.0	-0.8	0.2	-0.4	-0.9	-0.2
Medication: Atenolol	0.2	0.3	0.5	0.7	-0.0	0.4	0.6	0.4	0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.2	-0.5	0.1	-0.1	-0.7	-0.6
Impedance of leg (left)	0.2	1.0	2.9	-1.3	-0.1	1.0	-0.3	-0.4	-1.7
Leg predicted mass (left)	0.2	0.9	1.7	-0.2	-1.2	1.1	-1.3	-0.8	-0.6
Heart attack	0.2	0.3	0.5	0.4	-0.7	-0.2	0.6	-0.6	0.7
Allergy	0.2	0.5	1.1	0.3	-0.8	-0.3	-1.0	-0.9	-0.8
Diabetes (self-reported)	0.2	0.4	1.0	0.0	0.9	0.6	0.3	1.0	-0.3
Weight	0.2	0.8	1.6	-0.2	-0.9	1.1	-1.3	-0.7	-1.0
Arm fat percentage (right)	0.2	0.9	2.6	1.6	0.3	1.4	-0.3	0.6	-0.5
Trunk fat-free mass	0.2	1.2	1.9	-1.1	-1.3	0.3	-1.4	-1.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.3	0.4	0.6	-0.0	0.7	0.6
Medication: Cholesterol lowering	0.2	0.3	0.7	0.4	0.8	0.1	0.6	0.9	0.4
Medication: Lansoprazole	0.2	0.2	0.7	-0.2	0.6	0.0	-0.3	-0.0	-0.9
Prospective memory result	0.2	0.2	0.8	0.6	0.9	-0.3	-0.2	0.1	0.3
Lung cancer (father)	0.2	0.2	0.7	0.5	0.5	-0.4	-0.8	0.0	-0.2
Impedance of arm (left)	0.2	0.9	3.9	-0.5	0.1	2.0	0.3	0.3	-0.9
Trunk predicted mass	0.2	1.1	1.9	-1.1	-1.2	0.2	-1.4	-1.3	-0.6
Peak expiratory flow (PEF)	0.2	0.4	1.1	0.4	0.6	0.1	1.0	0.7	0.7
Medication: Amlodipine	0.2	0.3	1.1	0.8	-1.0	0.5	0.0	-0.2	0.1
Body fat percentage	0.2	0.9	2.9	0.8	0.0	1.7	-0.7	0.1	-1.2
Leg fat percentage (right)	0.2	0.7	2.0	1.4	0.3	1.3	-0.3	0.4	-0.3
Arm fat-free mass (right)	0.2	1.3	2.5	-0.9	-1.3	0.2	-1.6	-1.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.8	0.4	-0.1	-0.0	0.5	0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.4	0.6	0.3	0.9	0.8	0.2
Mean time to correctly identify matches	0.2	0.3	0.9	-0.4	0.9	-0.8	-0.1	0.2	-0.6
Whole body fat mass	0.2	0.9	2.2	0.2	-0.3	1.5	-1.1	-0.3	-1.3
Leg fat mass (right)	0.2	0.8	2.1	0.6	-0.4	1.4	-1.1	-0.3	-0.9
Comparative height size at age 10	0.2	0.9	4.5	-0.4	-0.1	2.1	-0.2	0.2	0.8
Illnesses of siblings: Diabetes	0.2	0.3	1.0	0.1	-0.2	1.0	0.5	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.6	-1.3	-0.4	-0.0	0.1	0.1	-0.9
Whole body fat-free mass	0.2	1.1	2.0	-0.8	-1.3	0.6	-1.4	-1.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.6	-0.0	0.2	-0.6	-0.6	-0.5
Friendships satisfaction	0.2	0.2	0.4	-0.4	-0.4	-0.6	0.5	0.3	0.6
Medication: Gliclazide	0.2	0.3	0.6	-0.4	0.7	-0.5	-0.1	0.3	-0.8
Whole body water mass	0.2	1.1	2.0	-0.8	-1.2	0.5	-1.4	-1.2	-0.8
Leg predicted mass (right)	0.2	0.8	1.6	-0.4	-1.0	1.1	-1.3	-0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	0.4	0.6	-0.8	0.5	0.3	0.2
Basal metabolic rate	0.2	1.0	2.0	-0.7	-1.1	0.8	-1.4	-1.0	-0.9
Leg fat percentage (left)	0.2	0.6	1.7	1.3	0.4	1.2	-0.4	0.3	-0.5
Arm fat-free mass (left)	0.2	1.0	1.9	-0.9	-1.0	0.3	-1.4	-1.1	-1.0
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.8	-0.7	-0.1	-0.3	-0.5	-0.4
Impedance of whole body	0.2	1.0	3.1	-0.9	0.2	1.8	-0.0	0.1	-1.5
Leg fat mass (left)	0.2	0.8	1.6	0.5	-0.4	1.3	-1.2	-0.4	-1.1
Bipolar Disorder (2018)	0.1	0.1	0.3	0.4	-0.6	-0.2	-0.3	-0.2	-0.2
Crohns Disease (2017)	0.1	0.3	0.6	0.4	0.2	-0.8	0.7	0.4	0.7
Major Depression (MDD)	0.1	0.1	0.5	0.1	0.2	0.3	-0.7	0.2	-0.1
Prostate Cancer	0.1	0.2	0.5	0.5	-0.1	-0.7	0.1	-0.5	0.4
Mean Putamen Volume	0.1	0.1	0.4	0.6	-0.2	0.4	-0.2	0.0	-0.3
Schizophrenia (2014)	0.1	0.2	0.8	0.3	0.1	-0.9	-0.4	-0.2	-0.5
Blood Platelet Count	0.1	1.6	3.4	1.0	0.9	1.0	1.8	1.6	0.9
Blood White Count	0.1	1.0	2.1	0.7	1.0	-1.3	-1.5	0.2	-1.0
BMI	0.1	0.5	2.0	1.4	0.3	0.8	0.1	0.6	0.3
Allergy or Eczema	0.1	0.3	0.7	-0.1	0.6	0.2	0.7	0.8	0.6
Lung FEV1/FVC ratio	0.1	0.6	1.2	-0.8	-0.5	-0.9	0.2	-1.1	-0.7
Hair Pigment	0.1	1.6	4.8	-0.3	-1.3	-0.4	-2.2	-1.5	-0.7
Tanning	0.1	1.7	3.1	0.9	1.7	-0.4	1.8	1.3	1.2
Number of treatments/medications taken	0.1	0.2	0.6	0.8	-0.1	-0.1	0.4	0.7	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.1	-0.2	-0.6	0.0	0.3	0.1
Medication for hormone replacement therapy	0.1	0.1	0.4	0.6	0.6	0.1	0.2	0.3	-0.2
Severe depression (siblings)	0.1	0.2	0.3	0.1	0.4	0.5	-0.3	0.6	0.2
Impedance of leg (right)	0.1	0.7	1.7	-1.1	-0.2	1.1	-0.1	-0.2	-1.3
Age when periods started (menarche)	0.1	0.2	0.6	0.3	0.2	0.8	0.3	0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.4	-0.7	0.7	0.3	-0.2	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.2	0.1	0.1	0.6	0.6	0.7
Medication: Levothyroxine sodium	0.1	0.2	1.0	-1.0	-0.4	-0.1	-0.3	-0.2	-0.2
Body mass index (BMI)	0.1	0.3	1.5	1.2	-0.1	0.4	-0.3	0.1	0.1
Waist circumference	0.1	0.2	0.6	-0.0	-0.3	0.2	-0.8	-0.4	-0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.4	-0.5	0.7	-0.2	-0.1	0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.0	-0.7	0.5	0.1	-0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.6	-0.2	0.1	-0.1	0.1	-0.2
Arm fat mass (right)	0.1	0.5	1.5	0.7	-0.2	1.2	-0.7	-0.0	-0.8
Headache pain in last month	0.1	0.2	0.4	-0.0	-0.4	-0.4	0.7	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.5	-0.5	0.6	-0.0	-0.0	0.5
Comparative body size at age 10	0.1	0.1	0.4	0.3	-0.0	-0.7	-0.5	0.1	-0.2
Age at first live birth	0.1	0.2	0.4	0.3	0.6	0.2	0.2	0.4	0.4
Medication: Ibuprofen	0.1	0.1	0.3	0.3	-0.5	0.5	-0.3	-0.2	-0.3
Age at last live birth	0.1	0.1	0.4	-0.2	0.6	0.1	-0.2	0.0	0.2
Leg fat-free mass (right)	0.1	0.8	1.5	-0.3	-1.0	1.1	-1.2	-0.7	-0.7
Arm fat percentage (left)	0.1	0.6	1.7	1.3	0.1	1.1	-0.4	0.3	-0.5
Loneliness, isolation	0.1	0.2	0.7	0.2	0.0	0.8	-0.3	0.5	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.5	0.4	0.2	-0.5	0.1	-0.7
Arm fat mass (left)	0.1	0.5	1.1	0.7	-0.2	1.1	-0.8	-0.1	-0.7
Guilty feelings	0.1	0.2	1.1	-0.0	0.4	0.2	-0.3	0.1	-1.0
Medication: Blood pressure	0.1	0.2	1.0	-0.0	1.0	-0.1	0.0	0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	0.0	-0.2	0.7	-0.0	0.1	-0.6
Risk taking	0.1	0.2	0.8	-0.5	0.9	0.1	0.3	0.2	-0.2
Unable to work because of sickness or disability	0.1	0.2	0.7	0.3	0.2	-0.9	0.0	0.2	-0.3
Pain experienced in last month	0.1	0.1	0.4	0.3	-0.1	0.7	0.2	-0.2	0.5
Blood Eosinophil Count	0.0	0.3	0.7	0.4	0.5	0.8	-0.4	0.3	-0.8
Taking other prescription medications	0.0	0.1	0.2	0.0	-0.2	-0.1	0.1	0.5	-0.0
Mouth/teeth dental problems	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.3	-0.2	-0.2
Number of live births	0.0	0.1	0.2	0.5	-0.0	-0.1	-0.1	-0.2	0.3
Back pain experienced in last month	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1	-0.1	-0.1

Hub : Genes

SLC40A1

Models

Trait associations