Hub : Genes

SLC4A4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.044 0.019 0.0062 0.005 0.022 0.016 0.019 0.010 0.077 0.00097 0.00410 0.0019 0.017
2 GTEx Cells Transformed fibroblasts 0.114 0.047 0.0064 0.009 NA 0.045 NA 0.013 0.065 NA 0.00024 NA 0.033

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.2 0.1
Bipolar Disorder or Schizophrenia 0.4 1.0 2.0 -0.0 1.4
Depressed Affect (Nagel 2018) 0.9 1.8 2.0 1.3 -1.4
Depression (Nagel 2018) 0.8 1.1 1.3 1.1 -1.0
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.1 0.2 0.3
Neuroticism (Nagel 2018) 0.8 1.8 2.0 1.3 -1.4
Schizophrenia (2018) 0.7 1.5 3.0 0.1 1.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.5 0.4 0.7
Worry (Nagel 2018) 1.2 2.6 4.6 0.7 -2.1
Alzheimer’s Disease (in mother) 0.5 0.6 1.1 0.3 -1.1
Alzheimer’s Disease (in father) 0.3 0.3 0.4 0.6 0.5
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 0.0 -0.7
Crohns Disease (2017) 0.2 0.5 1.1 1.0 0.2
Irritable Bowel Disease (IBD) 0.7 1.8 3.2 0.6 1.8
Ulcerative Colitis (UC) 1.5 2.8 5.5 -0.2 2.4
Major Depression (MDD) 0.3 0.4 0.8 -0.9 -0.0
Reaction Time 0.1 0.2 0.3 -0.5 0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.6 0.8 0.5
Breast Cancer 0.3 0.8 1.3 1.1 -0.5
Ovarian Cancer 0.5 0.6 0.7 0.7 0.9
Prostate Cancer 0.6 0.8 1.0 -0.8 1.0
Age at First Birth 0.1 0.2 0.2 0.4 -0.5
Bipolar Disorder (2011) 1.0 1.0 1.7 -1.3 -0.5
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 1.2 -0.2
Coronary Artery Disease (CAD) 0.3 0.4 0.5 -0.7 0.5
Crohns Disease (2012) 1.2 2.0 2.5 1.6 -1.2
Mean Putamen Volume 3.6 4.1 8.1 0.4 -2.8
Fasting Glucose 0.0 0.0 0.1 -0.3 0.1
HbA1C 1.4 1.6 3.1 1.8 0.2
HDL Cholesterol 0.6 1.1 1.8 0.5 -1.4
LDL Cholesterol 0.8 1.3 1.9 -0.8 1.4
Lupus 0.3 0.4 0.8 -0.9 0.1
Neuroticism (2016) 0.7 1.0 1.5 1.2 -0.7
Primary Biliary Cirrhosis 0.4 0.6 1.0 -0.3 1.0
Rheumatoid Arthritis 1.1 1.4 2.8 -0.4 -1.7
Schizophrenia (2014) 0.9 1.9 3.6 0.6 1.9
Triglycerides 0.6 1.0 1.4 1.2 0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.7 0.1 0.8
Ulcerative Colitis 1.4 2.1 4.1 -0.4 2.0
Blood Eosinophil Count 0.7 5.5 10.8 3.3 -0.4
Blood Platelet Count 0.7 7.6 13.5 3.7 -1.3
Blood Red Count 0.4 3.7 5.7 -1.3 -2.4
Blood White Count 3.9 29.1 57.3 7.6 -0.9
Heel T-Score 4.6 36.8 61.2 -3.5 -7.8
BMI 0.0 0.2 0.2 -0.5 -0.4
Height 1.1 20.7 30.8 5.5 3.2
Waist Hip Ratio (WHR) 0.1 0.3 0.4 0.6 0.4
Systolic Blood Pressure 0.3 1.5 1.9 -1.1 -1.4
Smoking Status 0.3 0.7 1.4 0.2 1.2
Allergy or Eczema 0.3 0.7 0.9 -0.7 -0.9
Cardiovascular Disease 2.4 8.1 14.7 -1.2 -3.8
Hypothyroidism (self reported) 1.4 3.1 5.7 -0.8 -2.4
Respiratory disease 0.3 0.6 0.8 0.6 -0.9
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.7 0.8 0.6
Lung FEV1/FVC ratio 1.0 4.8 5.2 -2.1 -2.3
Lung FVC 0.0 0.3 0.4 0.3 0.7
Neuroticism 0.5 1.3 2.2 1.5 -0.7
Chronotype (morning person) 0.2 0.5 0.8 0.9 -0.5
Hair Pigment 0.0 0.9 1.7 -1.3 -0.4
Tanning 0.2 2.4 2.7 1.6 1.5
Hand grip strength (left) 0.5 1.4 2.2 0.8 1.5
Number of treatments/medications taken 6.1 11.0 22.0 0.1 -4.7
Average weekly spirits intake 0.8 1.0 1.6 1.3 0.6
Sensitivity / hurt feelings 0.4 0.7 1.0 1.0 0.5
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.0 0.1 0.0
Hearing difficulty/problems: Yes 0.2 0.4 0.5 0.5 -0.7
Relative age of first facial hair 0.9 1.9 2.2 1.5 1.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.1 1.0 0.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.7 -1.6 -0.4
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 -0.1 -0.3
Systolic blood pressure, automated reading 0.4 1.1 1.6 -0.7 -1.3
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 3.0 1.7 0.9
Angina 0.4 0.5 0.8 -0.4 -0.9
Medication for hormone replacement therapy 2.1 2.3 3.8 -0.9 -2.0
Vitamin and mineral supplements 0.3 0.4 0.4 0.6 -0.6
Supplements: Zinc 0.0 0.0 0.0 0.1 -0.1
Medication: Co-codamol 1.0 1.2 1.4 1.2 -1.0
Medication: Metformin 0.6 0.8 1.6 1.2 0.2
Diabetes (father) 2.0 2.5 4.9 0.4 2.2
Diabetes (mother) 0.6 0.8 1.0 0.8 1.0
Severe depression (siblings) 0.8 0.9 1.7 -1.3 -0.3
Pack years adult smoking proportion 1.1 1.7 2.3 1.0 -1.5
Impedance of leg (right) 0.8 4.0 6.8 2.6 1.1
Leg fat-free mass (left) 0.1 0.5 0.7 0.5 0.9
Trunk fat percentage 0.2 1.0 1.8 0.4 -1.3
Hand grip strength (right) 0.2 0.6 1.0 0.5 1.0
Townsend deprivation index at recruitment 0.4 0.5 1.1 -0.2 1.0
Current tobacco smoking 0.4 0.7 1.4 -0.2 1.2
Average weekly fortified wine intake 1.0 1.2 2.3 -0.3 1.5
Maternal smoking around birth 0.7 1.0 1.3 1.1 0.9
Fed-up feelings 0.3 0.5 0.9 1.0 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 2.5 1.6 -0.5
Relative age voice broke 0.3 0.5 0.9 1.0 -0.1
Taking other prescription medications 1.6 2.5 4.7 0.6 -2.2
Age when periods started (menarche) 0.6 1.5 2.8 1.7 -0.4
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 2.4 -1.5 0.4
Heel bone mineral density (BMD) T-score, automated (left) 2.6 6.0 10.3 -1.3 -3.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.2 0.8
Qualifications: CSEs or equivalent 0.2 0.3 0.5 -0.7 0.1
Serious illness, injury or assault to yourself 0.6 0.7 0.9 0.9 0.7
High blood pressure 1.9 5.2 9.7 -0.8 -3.1
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 -0.1 0.1
Multivitamins +/- minerals 0.0 0.1 0.1 -0.3 -0.2
Stomach or abdominal pain in last month 0.1 0.1 0.1 0.3 0.2
Supplements: Glucosamine 0.3 0.4 0.7 -0.8 0.2
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 1.9 -1.0 -1.4
Medication: Atenolol 1.4 1.7 1.8 1.3 -1.4
Medication: Levothyroxine sodium 1.0 1.7 2.4 -1.0 -1.5
Sitting height 0.7 4.9 7.1 2.7 1.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.5 -0.1
High blood pressure (mother) 0.4 0.5 0.7 -0.9 0.6
Body mass index (BMI) 0.2 0.7 0.8 -0.7 -0.9
Impedance of leg (left) 0.7 3.6 6.2 2.5 1.0
Leg predicted mass (left) 0.1 0.5 0.6 0.6 0.8
Trunk fat mass 0.2 0.9 1.0 1.0 -0.9
Waist circumference 0.0 0.0 0.1 0.2 -0.2
Number of incorrect matches in round 0.7 1.1 1.8 -0.6 1.3
Past tobacco smoking 0.0 0.0 0.1 0.3 0.2
Alcohol usually taken with meals 0.4 0.6 1.0 1.0 0.4
Nervous feelings 1.0 1.9 2.7 -1.0 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 0.3 0.5
Hearing difficulty/problems with background noise 0.9 1.4 2.5 0.6 -1.6
Hair/balding pattern: Pattern 2 0.5 0.6 0.9 -0.9 0.5
Had menopause 0.2 0.2 0.4 0.2 0.6
Had other major operations 0.6 0.7 1.0 0.6 1.0
Forced vital capacity (FVC) 0.9 3.5 4.9 2.2 1.4
Heel bone mineral density (BMD) T-score, automated (right) 3.7 8.4 14.3 -1.6 -3.8
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.5 0.6 0.7
Qualifications: None of the above 0.8 1.6 2.9 1.7 0.6
Financial difficulties in last 2 years 0.4 0.6 0.9 -0.5 1.0
Mouth/teeth dental problems 0.8 1.3 1.3 -1.1 1.1
Heart attack 0.1 0.2 0.2 0.4 -0.4
Allergy 0.0 0.1 0.1 -0.2 0.4
Pain all over the body in last month 0.4 0.4 0.7 0.3 -0.9
Diabetes (self-reported) 0.4 0.7 0.8 0.9 0.7
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 2.8 0.8 -1.7
Medication: Ramipril 1.0 1.2 1.7 0.9 -1.3
Medication: Simvastatin 2.4 3.5 6.2 -0.9 -2.5
Fluid intelligence score 0.1 0.2 0.2 0.4 -0.4
Illnesses of siblings 0.1 0.2 0.2 0.5 -0.5
Neuroticism score 0.7 1.4 2.8 1.7 -0.2
Weight 0.1 0.5 1.0 1.0 0.1
Impedance of arm (right) 0.1 0.3 0.6 -0.8 0.0
Arm fat percentage (right) 0.2 1.0 1.0 -1.0 -1.0
Trunk fat-free mass 0.6 3.2 3.8 1.9 1.6
Hip circumference 0.0 0.1 0.3 0.1 -0.5
Time employed in main current job 0.3 0.4 0.6 0.8 -0.4
Alcohol intake versus 10 years previously 1.0 1.5 2.9 -0.2 1.7
Father’s age at death 2.1 2.9 5.3 0.7 2.3
Worrier / anxious feelings 0.9 1.7 3.3 0.2 -1.8
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 5.3 2.3 -0.4
Falls in the last year 0.7 0.9 1.5 1.2 -0.6
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 0.1 -0.4
Number of live births 0.0 0.0 0.0 -0.1 -0.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.6 1.3 0.7
Pulse rate 0.4 0.7 1.4 1.2 -0.1
Happiness 1.1 1.4 2.6 -0.3 1.6
Noisy workplace 0.7 0.9 1.3 0.7 1.2
Qualifications: A levels/AS levels or equivalent 0.6 1.3 1.6 -1.3 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 2.5 -1.6 -1.4
Mouth/teeth dental problems: Dentures 0.7 1.1 1.3 1.1 -1.0
Asthma 0.7 1.5 2.8 0.3 -1.7
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 2.3 -0.3 -1.5
Medication: Cholesterol lowering 1.1 1.6 3.0 0.5 -1.7
Depression (self-reported) 1.1 1.3 2.0 -1.4 -0.7
Medication: Lansoprazole 0.5 0.6 1.0 0.4 -1.0
Prospective memory result 1.6 2.0 3.9 2.0 -0.2
Lung cancer (father) 0.2 0.3 0.3 -0.5 0.5
Illnesses of mother 0.8 0.9 1.6 0.5 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 0.8 0.7 0.9
Pulse wave Arterial Stiffness index 3.2 3.7 7.4 -0.1 -2.7
Impedance of arm (left) 0.0 0.2 0.2 -0.4 -0.5
Arm fat mass (right) 0.0 0.0 0.0 0.1 -0.1
Trunk predicted mass 0.5 3.0 3.8 1.9 1.5
Standing height 0.8 8.4 11.8 3.4 2.2
Length of working week for main job 0.1 0.1 0.1 0.3 -0.2
Exposure to tobacco smoke at home 1.8 2.1 2.4 -1.6 1.3
Breastfed as a baby 3.2 4.0 4.0 -2.0 -2.0
Tense / ‘highly strung’ 1.3 2.2 3.2 1.8 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.6 0.8 -1.3
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 -0.4 -0.0
Birth weight of first child 0.1 0.1 0.3 -0.5 0.0
Peak expiratory flow (PEF) 0.0 0.0 0.1 -0.1 0.2
Pulse wave reflection index 1.9 2.4 3.1 -1.3 -1.8
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.8 0.9 -0.1
Loud music exposure frequency 0.3 0.4 0.5 0.7 -0.4
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 2.4 -1.6 -1.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.5 0.7 -0.2
Blood clot in the leg (DVT) 0.5 0.7 1.1 1.1 0.5
Medication: Paracetamol 0.3 0.4 0.8 0.1 -0.9
Headache pain in last month 0.4 0.6 1.2 0.1 1.1
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 7.5 -0.3 2.7
Glaucoma (self-reported) 0.2 0.2 0.4 -0.7 -0.1
Gout (self-reported) 0.5 0.7 0.7 0.8 0.8
Hypothyroidism/myxoedema (self-reported) 2.4 4.8 9.0 -0.7 -3.0
Medication: Amlodipine 1.0 1.4 2.1 -1.4 -0.8
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.4 -1.6 -0.4
Birth weight 0.4 0.8 1.0 -1.0 -0.7
Chronic bronchitis/emphysema (mother) 0.9 1.0 1.7 -0.5 -1.3
High blood pressure (siblings) 0.2 0.3 0.5 -0.4 0.7
Forced vital capacity (FVC), Best measure 0.5 2.0 2.2 1.3 1.5
Body fat percentage 0.2 0.9 1.4 0.6 -1.2
Leg fat percentage (right) 0.3 1.1 1.5 1.2 -0.9
Arm fat-free mass (right) 0.5 2.6 4.5 2.1 0.9
Exposure to tobacco smoke outside home 0.0 0.0 0.0 -0.2 -0.2
Comparative body size at age 10 0.2 0.6 1.1 -1.1 0.3
Number of full brothers 1.3 1.6 3.0 -0.4 1.7
Worry too long after embarrassment 0.6 0.9 1.9 -0.1 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.1 -0.2 -1.1
Wheeze or whistling in the chest in last year 0.3 0.5 1.0 1.0 -0.2
Number of children fathered 2.0 2.2 3.8 -0.8 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 1.6 1.3 1.0
Age at first live birth 0.1 0.2 0.3 -0.6 0.3
Pulse wave peak to peak time 3.4 4.0 8.0 0.3 2.8
Health satisfaction 0.3 0.4 0.8 0.9 0.2
Shortness of breath walking on level ground 0.2 0.3 0.5 -0.7 -0.0
Qualifications: College or University degree 0.1 0.5 0.7 0.5 0.8
Eye problems/disorders: None of the above 1.2 1.4 1.7 -1.1 1.3
Mouth/teeth dental problems: Loose teeth 0.7 0.9 1.3 -0.7 -1.1
Emphysema/chronic bronchitis 0.2 0.2 0.4 0.6 -0.2
Medication for pain relief, constipation, heartburn 2.6 4.4 8.1 -0.9 2.8
Neck or shoulder pain in last month 1.2 1.8 3.4 0.4 -1.8
Medication: Blood pressure 1.6 2.9 5.7 0.3 -2.4
Angina (self-reported) 0.6 0.7 1.2 -0.5 -1.1
Migraine (self-reported) 2.0 2.5 3.2 -1.3 -1.8
Medication: Ibuprofen 2.1 2.5 4.1 -0.9 -2.0
Medication: Allopurinol 1.2 1.6 3.3 1.8 0.0
Medication: Omeprazole 0.4 0.4 0.8 0.0 -0.9
Medication: Seretide 50 evohaler 0.0 0.0 0.1 0.3 -0.0
Mean time to correctly identify matches 0.1 0.2 0.3 0.6 -0.2
Heart disease (mother) 0.6 0.7 0.8 -0.7 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.0 -0.1 -0.1
Whole body fat mass 0.1 0.4 0.6 0.8 -0.5
Leg fat mass (right) 0.2 0.7 1.3 1.1 -0.3
Arm predicted mass (right) 0.5 2.5 4.1 2.0 0.9
Pulse rate, automated reading 1.0 3.3 4.1 1.6 -2.0
Alcohol intake frequency. 0.1 0.1 0.3 -0.0 -0.5
Comparative height size at age 10 1.1 6.2 7.9 2.1 2.8
Number of full sisters 0.7 0.8 1.5 -0.3 -1.2
Suffer from ‘nerves’ 0.2 0.3 0.7 0.8 -0.2
Overall health rating 0.5 1.1 1.2 1.1 1.0
Chest pain or discomfort 0.6 0.9 1.2 -0.8 -1.1
Had major operations 0.4 0.5 0.5 0.7 -0.6
Age at last live birth 0.7 1.0 1.4 -1.2 -0.8
Family relationship satisfaction 2.1 2.6 4.1 -1.1 2.0
Leg pain on walking 0.2 0.2 0.5 0.7 0.0
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 4.1 0.2 -2.0
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.1 0.8 -1.4
Illness, injury, bereavement, stress in last 2 years 2.2 2.6 5.0 2.2 -0.5
Medication: Aspirin 0.6 0.8 1.3 0.6 -1.2
Supplements: Vitamin C 1.6 1.9 3.6 -1.9 0.5
Knee pain experienced in last month 1.2 1.9 3.2 -1.8 -0.7
Hypertension (Self-reported) 2.5 7.0 12.6 -1.1 -3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.3 -0.2
Illnesses of father: Heart disease 3.1 4.3 7.3 -2.7 -1.1
Illnesses of siblings: Diabetes 0.3 0.4 0.8 0.1 0.9
Smoking status: Previous 0.0 0.1 0.1 0.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 4.2 2.1 1.0
Whole body fat-free mass 0.3 1.9 2.1 1.4 1.3
Leg fat-free mass (right) 0.1 0.4 0.8 0.2 0.9
Arm fat percentage (left) 0.3 1.1 1.6 -0.8 -1.3
Average weekly red wine intake 0.8 1.1 2.2 -1.5 -0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.2 0.5 -0.4
Mood swings 1.6 2.9 5.8 2.4 -0.1
Loneliness, isolation 0.3 0.4 0.8 0.9 -0.2
Long-standing illness, disability or infirmity 0.3 0.5 0.9 0.2 1.0
Ever had bowel cancer screening 1.1 1.2 1.7 -0.9 -1.3
Diabetes diagnosed by doctor 1.2 2.0 2.2 1.5 1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.3 1.5 -0.8
Friendships satisfaction 0.8 1.0 2.0 -1.4 0.3
Qualifications: nursing, teaching 1.6 2.5 4.2 -1.0 2.0
Commuting to job workplace: Walk 1.2 1.3 2.6 -1.6 0.0
Eye problems/disorders: Cataract 0.1 0.1 0.2 0.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.4 -0.1
Medication for cholesterol 2.6 4.0 4.3 2.1 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.8 0.9 0.0
Back pain experienced in last month 0.8 1.2 2.1 -0.4 -1.5
Mineral and other dietary supplements 1.3 1.8 2.1 1.4 1.2
Breast cancer (self-reported) 0.7 0.8 1.5 0.4 1.2
Asthma (self-reported) 0.8 1.6 3.0 0.5 -1.7
Osteoporosis (self-reported) 0.4 0.5 1.0 -0.2 -1.0
Osteoarthritis (self-reported) 1.8 2.3 4.5 -0.2 -2.1
Medication: Aspirin 0.9 1.2 2.0 0.6 -1.4
Medication: Gliclazide 1.1 1.3 2.5 -0.2 1.6
Illnesses of father: None of the above (group 1) 0.3 0.4 0.6 -0.4 0.8
Smoking status: Current 0.3 0.5 0.9 -0.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.7 0.8 -0.3
Whole body water mass 0.3 1.7 1.9 1.4 1.3
Leg predicted mass (right) 0.1 0.3 0.6 0.2 0.8
Arm fat mass (left) 0.0 0.2 0.3 -0.1 -0.6
Number of self-reported non-cancer illnesses 2.1 3.6 6.0 -1.1 -2.4
Average weekly champagne plus white wine intake 0.2 0.3 0.5 0.7 0.3
Miserableness 0.6 1.1 2.0 0.4 -1.4
Guilty feelings 0.5 0.8 1.6 1.3 0.1
Wears glasses or contact lenses 1.0 1.1 1.6 0.8 -1.3
Ever taken oral contraceptive pill 1.9 2.2 2.4 1.6 1.4
Hearing aid user 0.2 0.2 0.4 0.6 -0.1
Mother’s age at death 0.7 0.9 1.2 -0.7 -1.1
Financial situation satisfaction 0.4 0.5 0.5 -0.7 0.7
Tinnitus: Yes, now most or all of the time 1.3 1.5 2.4 -1.6 -0.7
Commuting to job workplace: Public transport 1.6 1.9 3.8 -0.1 1.9
Eye problems/disorders: Glaucoma 0.6 0.7 1.3 -0.3 -1.1
Medication: Blood pressure 0.8 1.5 1.6 -1.2 -1.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 1.9 1.2 -1.4
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.0 -1.4 -0.3
High cholesterol (Self-reported) 1.0 1.8 3.4 -0.3 -1.8
Medication: Bendroflumethiazide 1.0 1.5 2.5 -1.6 -0.7
Medication: Paracetamol 0.4 0.6 1.2 -0.1 -1.1
Medication: Lisinopril 0.9 1.2 2.0 1.4 -0.6
Medication: Atorvastatin 0.0 0.0 0.0 0.1 0.0
Illnesses of father: High blood pressure 0.8 1.0 1.8 -0.3 -1.3
Alcohol drinker status: Never 0.0 0.0 0.0 0.0 0.0
Ever smoked 0.1 0.2 0.3 -0.4 0.6
Basal metabolic rate 0.3 1.8 2.2 1.5 1.2
Leg fat percentage (left) 0.3 0.9 1.1 1.1 -0.9
Arm fat-free mass (left) 0.5 2.6 3.7 1.9 1.2
Number of operations (self-reported) 0.4 0.6 1.1 1.0 -0.4
Average weekly beer plus cider intake 0.6 0.8 1.2 1.1 -0.7
Irritability 1.2 2.1 4.2 2.0 -0.2
Risk taking 0.0 0.0 0.0 0.0 -0.1
Ever had prostate specific antigen (PSA) test 1.2 1.4 1.8 1.4 -1.0
Fractured/broken bones in last 5 years 1.2 1.5 3.0 1.7 0.2
Age started oral contraceptive pill 0.2 0.2 0.4 0.3 0.6
Diastolic blood pressure, automated reading 1.2 3.7 6.5 -1.0 -2.5
Ever depressed for a whole week 0.5 0.7 0.7 0.9 0.8
Unable to work because of sickness or disability 0.5 0.6 1.0 1.0 -0.5
Commuting to job workplace: Cycle 0.5 0.6 1.0 -1.0 0.3
Myopia 0.1 0.1 0.1 0.3 0.3
Vascular/heart problems diagnosed by doctor 2.5 6.8 13.0 0.8 3.6
Cholesterol lowering medication 0.3 0.5 0.8 -0.9 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.2 0.4 -0.5
Pain experienced in last month 0.3 0.4 0.8 0.3 0.9
Supplements: Calcium 1.3 1.4 2.6 -1.6 0.5
Basal cell carcinoma (self-reported) 0.7 0.9 1.6 0.4 -1.3
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.2 0.4 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 1.8 1.3 0.9
Heart disease (siblings) 0.2 0.3 0.5 0.0 -0.7
Alcohol drinker status: Previous 0.4 0.4 0.8 0.9 -0.1
Pack years of smoking 1.2 1.7 2.7 0.9 -1.6
Impedance of whole body 0.1 0.4 0.7 0.9 -0.2
Leg fat mass (left) 0.1 0.5 0.9 1.0 -0.2
Arm predicted mass (left) 0.6 3.3 4.2 2.0 1.6