Hub : Genes

SLC9A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.1760 0.0480 1.1e-06 0.092 NA 0.083 NA 0.079 4.0e-05 NA 9.2e-05 NA 1.3e-04
2 GTEx Heart Left Ventricle 0.0919 0.0399 1.6e-03 0.082 NA 0.022 NA 0.071 3.7e-05 NA 2.4e-02 NA 1.2e-04
3 GTEx Testis 0.1370 0.0660 7.3e-03 0.086 NA 0.095 NA 0.094 1.1e-04 NA 5.3e-05 NA 5.8e-05
4 GTEx Thyroid 0.1000 0.0460 6.4e-03 0.050 NA 0.021 NA 0.045 1.1e-04 NA 8.8e-03 NA 2.2e-04
5 METSIM Adipose 0.0531 0.0211 2.0e-05 0.067 0.033 0.059 0.046 0.060 3.2e-10 7.6e-06 3.2e-09 1.9e-07 2.3e-09
6 TCGA Prostate Adenocarcinoma 0.1055 0.0394 1.0e-09 0.040 0.078 0.102 NA 0.107 4.5e-05 1.5e-08 9.3e-11 NA 3.0e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.0 0.0 0.1 0.3 0.0 0.1 -0.0 -0.2 0.2
Bipolar Disorder or Schizophrenia 0.9 2.2 3.5 1.1 1.8 1.7 1.3 -1.9 0.9
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.5 0.3 0.3 0.6 0.3 -0.1
Depression (Nagel 2018) 0.4 0.7 1.2 1.1 0.9 0.4 0.8 -0.4 0.9
Intelligence (Savage-Jansen 2018) 1.0 3.0 3.9 1.5 2.0 1.9 1.6 -1.7 1.6
Neuroticism (Nagel 2018) 0.0 0.1 0.2 0.1 0.1 0.4 0.4 0.4 0.0
Schizophrenia (2018) 1.6 3.3 5.3 1.2 2.3 2.0 1.7 -2.3 0.9
Schizophrenia vs Biploar Disorder 0.3 0.3 1.0 -0.7 0.0 -0.2 -0.3 0.6 -1.0
Worry (Nagel 2018) 0.8 1.7 3.0 -1.7 -1.3 -0.4 -1.7 1.4 -1.0
Alzheimer’s Disease (in mother) 0.3 0.3 0.7 0.9 0.5 0.4 0.6 0.1 -0.6
Alzheimer’s Disease (in father) 2.1 2.3 3.5 -1.3 -1.5 -1.4 -1.5 1.5 -1.9
Alzheimer’s Disease (including proxy) 0.4 0.6 2.0 -0.2 -0.6 -0.6 -0.4 0.8 -1.4
Crohns Disease (2017) 0.1 0.1 0.3 0.2 0.2 -0.1 0.6 -0.0 -0.5
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 -0.4 0.2 -0.5 0.5 -0.2 -0.6
Ulcerative Colitis (UC) 0.1 0.2 0.5 -0.7 0.1 -0.7 0.2 -0.3 0.1
Major Depression (MDD) 1.7 2.1 2.9 1.6 1.6 1.7 1.5 -1.5 0.0
Reaction Time 0.5 0.9 2.2 -1.3 -0.8 -0.4 -1.5 0.5 -0.6
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.5 -0.7 -0.2 -0.1 -0.1 0.2 0.2
Breast Cancer 0.6 1.4 3.1 -0.6 -1.2 -1.8 -0.6 1.2 -1.3
Ovarian Cancer 0.7 0.9 2.6 -0.9 -0.8 -1.0 -0.7 1.6 0.2
Prostate Cancer 2.0 2.8 4.6 0.8 1.8 1.8 1.9 -2.1 1.3
Age at First Birth 2.4 3.5 5.0 2.2 2.2 1.6 2.1 -1.9 0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.1 1.4 2.5 1.2 1.3 0.8 1.6 -1.1 1.1
Coronary Artery Disease (CAD) 0.1 0.2 1.0 0.0 0.0 0.0 0.0 1.0 0.0
Crohns Disease (2012) 0.1 0.1 0.5 0.1 0.5 0.2 0.7 -0.4 -0.0
Mean Putamen Volume 0.2 0.2 0.4 0.4 0.3 -0.4 0.2 -0.6 0.6
Fasting Glucose 0.2 0.2 0.7 0.2 0.4 0.1 0.4 -0.4 -0.8
HbA1C 0.1 0.1 0.3 0.0 0.4 0.5 -0.1 -0.5 0.1
HDL Cholesterol 1.0 1.6 4.6 1.7 0.8 2.1 0.4 -0.9 0.8
LDL Cholesterol 0.6 0.9 2.5 -0.3 -0.8 -0.8 -0.4 1.2 -1.6
Lupus 0.6 0.9 2.2 -1.4 -1.1 -0.6 -1.5 0.1 -0.4
Neuroticism (2016) 0.6 0.8 2.3 -0.4 -1.0 -0.6 -0.6 1.5 -0.8
Primary Biliary Cirrhosis 0.1 0.2 0.4 0.4 0.3 0.2 0.3 -0.4 0.6
Rheumatoid Arthritis 0.1 0.2 0.5 -0.1 -0.3 -0.3 -0.7 0.3 0.4
Schizophrenia (2014) 1.3 2.8 4.5 1.0 2.0 2.0 1.4 -2.1 1.0
Triglycerides 0.1 0.2 0.5 -0.6 0.4 -0.1 0.7 0.1 -0.6
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.2 0.2 0.8 -0.9 0.3 -0.2 0.1 -0.6 -0.0
Blood Eosinophil Count 0.9 6.9 9.9 -2.1 -2.7 -3.1 -2.5 2.6 -2.6
Blood Platelet Count 0.8 9.3 15.5 -3.2 -3.3 -3.9 -2.8 2.9 -1.9
Blood Red Count 0.0 0.0 0.2 -0.1 -0.3 -0.4 -0.1 0.0 -0.1
Blood White Count 0.1 0.7 1.9 1.4 0.3 1.0 0.6 -0.9 0.6
Heel T-Score 0.3 2.4 4.8 1.3 1.3 2.2 0.9 -1.6 1.6
BMI 0.1 0.5 1.2 -0.0 0.6 0.9 1.1 -0.4 0.6
Height 0.5 9.7 16.7 -4.0 -3.3 -3.4 -4.1 1.8 -0.1
Waist Hip Ratio (WHR) 0.2 0.9 2.1 0.3 1.4 1.0 1.1 -0.9 0.5
Systolic Blood Pressure 4.5 22.3 29.3 -4.7 -4.9 -5.4 -5.2 4.5 -3.5
Smoking Status 1.0 2.3 4.7 1.3 1.6 1.8 2.2 -1.1 0.7
Allergy or Eczema 0.3 0.9 2.8 1.2 0.2 0.4 0.9 0.3 -1.7
Cardiovascular Disease 4.5 14.8 19.1 -3.2 -3.9 -4.4 -3.5 4.3 -3.6
Hypothyroidism (self reported) 0.2 0.4 1.1 -0.4 0.5 -0.4 0.8 0.0 -1.1
Respiratory disease 0.3 0.8 1.6 1.0 0.8 -0.0 1.2 -0.1 -1.3
Type 2 Diabetes (T2D) (2018) 0.9 1.6 5.2 -1.2 -0.7 -1.1 -0.2 1.2 -2.3
Lung FEV1/FVC ratio 0.2 0.8 1.5 0.2 1.0 1.0 0.9 -0.9 1.2
Lung FVC 0.3 1.6 2.4 1.1 1.4 1.4 0.7 -1.5 1.2
Neuroticism 0.0 0.1 0.3 -0.2 -0.0 -0.0 -0.2 0.5 -0.4
Chronotype (morning person) 2.4 5.6 7.9 -2.0 -2.8 -2.2 -2.8 2.2 -2.0
Hair Pigment 0.1 2.3 5.2 1.2 1.6 0.9 1.4 -1.4 2.3
Tanning 0.0 0.6 1.4 -0.7 -0.8 -0.8 -0.5 0.1 -1.2
Hand grip strength (left) 0.1 0.4 1.0 -0.6 -0.8 -0.4 -1.0 0.2 0.3
Number of treatments/medications taken 0.0 0.1 0.1 -0.3 0.0 -0.3 0.2 0.2 -0.2
Average weekly spirits intake 0.2 0.2 0.4 0.6 -0.2 -0.2 0.3 0.5 0.6
Sensitivity / hurt feelings 0.1 0.2 0.6 -0.8 -0.0 -0.1 0.1 0.6 0.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 0.7 0.5 0.4 0.3 -0.2 0.8
Hearing difficulty/problems: Yes 3.6 5.5 6.1 2.4 2.4 2.4 2.5 -2.3 2.1
Relative age of first facial hair 0.1 0.1 0.2 -0.5 -0.3 0.4 -0.4 -0.3 0.1
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.0 1.5 1.7 1.0 1.5 -1.3 0.7
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.4 -0.3 -0.6 0.1 -0.2 0.3 -0.6
Ever had hysterectomy (womb removed) 1.5 1.7 2.4 1.6 1.3 1.4 1.0 -1.3 1.2
Systolic blood pressure, automated reading 2.7 7.9 11.3 -3.0 -2.8 -3.4 -3.1 2.6 -1.7
Eye problems/disorders: Diabetes related eye disease 3.1 3.4 6.0 -1.8 -1.8 -2.4 -1.2 2.2 -1.1
Angina 1.2 1.5 2.2 -1.5 -1.2 -1.4 -0.7 1.2 -1.3
Medication for hormone replacement therapy 0.5 0.6 3.1 0.2 -0.3 0.1 -0.0 0.5 -1.8
Vitamin and mineral supplements 0.3 0.4 2.1 -0.0 -0.5 -0.0 -0.3 0.2 -1.5
Supplements: Zinc 1.4 1.5 2.9 -1.5 -1.4 -1.0 -1.7 0.9 0.2
Medication: Co-codamol 1.6 1.9 3.1 0.9 1.3 1.8 1.3 -1.5 1.2
Medication: Metformin 3.6 5.1 7.4 -2.5 -2.2 -2.1 -1.8 2.0 -2.7
Diabetes (father) 0.7 0.8 1.8 -0.7 -1.0 -0.5 -1.3 1.1 -0.4
Diabetes (mother) 9.1 11.6 14.5 -3.8 -3.5 -3.2 -3.6 3.0 -3.2
Severe depression (siblings) 0.1 0.1 0.6 0.0 0.1 0.3 -0.3 0.0 -0.7
Pack years adult smoking proportion 0.3 0.4 1.2 0.1 0.2 -0.3 0.8 0.8 -1.1
Impedance of leg (right) 0.1 0.6 1.8 0.1 -0.6 -1.0 -0.7 0.4 -1.3
Leg fat-free mass (left) 0.1 0.4 1.1 -1.1 -0.5 -0.4 -0.2 0.3 0.7
Trunk fat percentage 0.2 0.7 1.4 0.5 1.0 0.8 1.2 -0.8 0.6
Hand grip strength (right) 0.1 0.4 1.0 -0.2 -0.8 -0.1 -1.0 -0.0 0.8
Townsend deprivation index at recruitment 0.4 0.6 2.2 -0.9 -0.1 -0.5 0.4 0.7 -1.5
Current tobacco smoking 1.0 1.6 2.9 0.8 1.4 1.5 1.7 -1.0 0.8
Average weekly fortified wine intake 0.4 0.4 0.9 -0.5 0.7 0.7 0.6 -1.0 0.3
Maternal smoking around birth 0.7 1.0 1.8 0.8 1.2 1.0 1.3 -0.9 0.6
Fed-up feelings 0.2 0.3 1.1 0.1 -0.2 -0.4 0.3 1.1 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.3 0.5 0.2 -0.2 0.1 0.3 0.2
Relative age voice broke 0.5 0.7 1.8 0.5 0.5 1.3 -0.2 -1.1 1.0
Taking other prescription medications 0.7 1.1 1.7 0.9 1.2 0.7 1.3 -1.2 0.9
Age when periods started (menarche) 1.1 2.5 4.5 1.0 1.7 1.7 1.2 -2.1 1.5
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 1.9 -1.1 -1.0 -1.4 -0.9 1.2 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 5.9 -1.4 -1.9 -0.9 -2.4 1.7 -0.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.3 -0.0 -0.5 -0.0 -0.3 -0.2
Qualifications: CSEs or equivalent 1.1 1.4 2.0 1.3 1.4 1.1 1.2 -0.9 1.0
Serious illness, injury or assault to yourself 3.8 4.6 7.8 2.2 2.8 1.7 2.2 -2.1 1.6
High blood pressure 4.0 11.2 16.2 -2.9 -3.4 -4.0 -3.1 3.5 -3.0
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.7 0.9 -0.3 -0.2 0.5 1.2 -2.2
Multivitamins +/- minerals 1.3 1.6 4.7 0.7 1.5 0.8 1.0 -0.9 2.2
Stomach or abdominal pain in last month 0.9 1.1 4.3 1.1 0.5 0.9 0.2 -0.4 2.1
Supplements: Glucosamine 3.8 4.9 7.3 1.4 2.1 2.5 1.7 -2.7 2.6
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.7 1.3 0.7 0.4 0.9 -0.8 0.5
Medication: Atenolol 3.1 3.9 6.9 -1.6 -1.8 -2.6 -1.5 2.3 -1.8
Medication: Levothyroxine sodium 0.3 0.6 1.1 0.7 0.9 0.4 1.0 -0.8 0.0
Sitting height 0.7 4.7 8.4 -1.8 -2.5 -2.9 -2.7 1.8 -0.0
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 0.1 0.7 0.6 0.6 -0.3 -0.1
High blood pressure (mother) 4.2 5.9 7.6 -2.5 -2.7 -2.8 -2.4 2.7 -1.0
Body mass index (BMI) 0.1 0.5 1.1 0.1 0.6 1.0 1.0 -0.5 0.5
Impedance of leg (left) 0.2 1.1 2.2 -0.1 -0.9 -1.4 -1.1 0.8 -1.5
Leg predicted mass (left) 0.1 0.4 1.1 -1.1 -0.5 -0.3 -0.3 0.3 0.7
Trunk fat mass 0.1 0.4 0.5 -0.0 0.6 0.6 0.7 -0.6 0.7
Waist circumference 0.1 0.4 0.9 -0.3 0.7 0.5 0.9 -0.5 0.7
Number of incorrect matches in round 1.3 2.2 3.7 1.3 1.9 1.5 1.5 -1.5 1.2
Past tobacco smoking 0.2 0.3 1.0 1.0 0.2 0.3 0.2 -0.2 0.8
Alcohol usually taken with meals 0.5 0.7 1.4 0.7 0.9 0.6 0.9 -1.2 0.7
Nervous feelings 1.0 1.8 3.8 -2.0 -1.3 -1.0 -1.7 1.2 -0.5
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 3.2 -0.9 -1.5 -1.1 -1.4 1.8 -0.9
Hearing difficulty/problems with background noise 1.0 1.5 3.0 1.2 1.2 1.4 1.7 -0.9 0.7
Hair/balding pattern: Pattern 2 2.1 2.6 4.9 -0.6 -2.2 -1.2 -1.5 2.1 -1.5
Had menopause 1.2 1.5 2.6 1.0 1.1 1.5 0.3 -1.3 1.6
Had other major operations 0.7 0.8 1.8 1.3 1.0 0.5 1.3 -0.5 -0.1
Forced vital capacity (FVC) 0.3 1.0 2.2 -1.0 -1.1 -0.8 -1.5 0.8 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 4.0 -0.7 -1.6 -0.4 -2.0 1.2 0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.2 -1.5 -0.4 -1.2 -0.5 0.8 -0.8
Qualifications: None of the above 0.9 2.0 2.9 -1.3 -1.2 -1.6 -1.0 1.5 -1.7
Financial difficulties in last 2 years 0.2 0.3 0.3 0.6 0.6 0.5 0.4 -0.6 0.5
Mouth/teeth dental problems 0.8 1.2 4.8 0.8 -0.2 0.7 -0.2 -0.9 2.2
Heart attack 1.9 2.4 4.8 -1.5 -1.5 -2.2 -1.3 1.5 -1.3
Allergy 0.4 0.9 4.1 -0.7 0.1 -0.1 -0.3 -0.9 2.0
Pain all over the body in last month 0.4 0.4 0.8 -0.9 -0.6 -0.6 -0.8 0.5 -0.4
Diabetes (self-reported) 2.7 4.2 8.2 -2.2 -1.6 -2.0 -1.3 2.0 -2.9
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.2 -0.1 -0.2 -0.5 0.3 0.9 -1.1
Medication: Ramipril 1.9 2.5 4.0 -0.8 -1.6 -1.7 -1.2 2.0 -1.8
Medication: Simvastatin 3.6 5.2 6.1 -2.3 -2.2 -2.5 -2.3 2.2 -2.3
Fluid intelligence score 0.3 0.7 1.2 -0.7 -1.0 -0.2 -1.1 0.9 -0.6
Illnesses of siblings 0.2 0.3 0.7 -0.3 -0.5 -0.1 -0.8 0.6 -0.8
Neuroticism score 0.1 0.3 1.0 -0.6 -0.3 -0.2 -0.3 1.0 -0.1
Weight 0.0 0.2 0.9 -0.9 -0.3 -0.2 -0.1 -0.0 0.6
Impedance of arm (right) 0.1 0.4 0.7 0.8 0.9 -0.1 0.7 -0.4 -0.3
Arm fat percentage (right) 0.2 0.9 2.2 0.4 1.0 1.1 1.5 -0.7 0.4
Trunk fat-free mass 0.4 2.1 4.5 -2.1 -1.5 -1.6 -1.5 0.8 0.3
Hip circumference 0.0 0.2 0.5 0.0 0.2 0.2 0.5 -0.2 0.7
Time employed in main current job 0.1 0.1 0.2 -0.2 0.0 0.2 0.1 -0.3 0.5
Alcohol intake versus 10 years previously 0.8 1.2 3.2 -0.4 -1.8 -0.6 -1.4 1.0 -0.7
Father’s age at death 0.2 0.3 0.8 -0.2 -0.4 0.5 0.1 0.6 -0.9
Worrier / anxious feelings 0.2 0.4 1.0 -0.7 -0.6 0.2 -1.0 0.7 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.4 1.2 1.1 1.2 0.5 -0.7 1.1
Falls in the last year 1.9 2.6 3.9 1.7 1.9 1.7 1.3 -2.0 0.9
Hair/balding pattern: Pattern 3 0.6 0.9 1.9 0.4 1.2 1.4 0.9 -0.8 0.4
Number of live births 0.1 0.2 0.5 -0.7 0.1 0.1 -0.5 -0.2 -0.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.4 -0.9 -1.2 -0.9 -1.5 0.9 -0.3
Pulse rate 0.8 1.3 6.0 -0.3 -0.9 -0.2 -0.7 0.6 -2.5
Happiness 1.9 2.3 3.7 1.9 1.6 1.8 1.1 -1.1 1.3
Noisy workplace 0.7 0.8 1.5 0.5 1.0 1.0 1.1 -1.2 0.5
Qualifications: A levels/AS levels or equivalent 0.6 1.4 1.9 1.2 1.4 1.3 0.8 -1.0 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 3.2 -1.5 -1.1 -1.8 -1.3 1.3 -1.6
Mouth/teeth dental problems: Dentures 0.4 0.6 1.5 -1.2 0.1 -0.6 0.4 0.3 -1.2
Asthma 0.1 0.3 0.5 0.7 0.7 0.2 0.6 -0.4 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 1.5 0.5 0.7 0.9 0.8 -1.2 1.1
Medication: Cholesterol lowering 3.0 4.7 6.7 -2.4 -1.9 -2.6 -1.7 2.0 -2.3
Depression (self-reported) 0.3 0.3 1.1 -0.6 0.3 0.3 -0.2 -1.1 0.6
Medication: Lansoprazole 1.0 1.1 1.7 0.6 1.1 1.3 1.0 -1.3 1.0
Prospective memory result 0.4 0.5 0.9 0.1 0.6 0.9 0.7 -0.9 0.6
Lung cancer (father) 1.1 1.3 2.5 -1.5 -0.7 -1.6 -0.8 1.2 -0.7
Illnesses of mother 6.0 7.4 11.6 2.8 2.8 3.4 2.2 -3.0 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 3.5 -1.0 -1.4 -0.9 -1.9 0.8 0.1
Pulse wave Arterial Stiffness index 0.4 0.5 1.4 -1.2 -0.3 -0.2 -0.4 0.6 -0.9
Impedance of arm (left) 0.2 0.8 1.7 1.2 1.3 0.3 1.0 -0.9 0.2
Arm fat mass (right) 0.1 0.3 0.7 -0.2 0.5 0.7 0.8 -0.4 0.4
Trunk predicted mass 0.3 1.9 4.2 -2.1 -1.5 -1.6 -1.5 0.8 0.3
Standing height 0.3 3.3 6.1 -2.1 -1.8 -2.5 -2.3 0.8 0.5
Length of working week for main job 2.1 2.3 3.2 -1.3 -1.8 -1.6 -1.8 1.3 -1.3
Exposure to tobacco smoke at home 1.2 1.4 3.5 -1.4 -0.8 -0.8 -1.1 0.4 -1.9
Breastfed as a baby 0.4 0.5 2.0 0.3 -0.5 -0.3 -0.8 -0.2 1.4
Tense / ‘highly strung’ 0.4 0.7 1.2 -0.9 -0.7 -0.3 -0.6 1.1 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.1 4.2 1.6 1.9 2.1 2.0 -1.7 0.9
Hair/balding pattern: Pattern 4 0.1 0.2 1.1 -0.3 -0.2 0.1 -0.2 0.1 -1.0
Birth weight of first child 5.7 10.3 13.8 -2.7 -3.7 -3.3 -3.6 3.5 -2.2
Peak expiratory flow (PEF) 0.1 0.2 0.7 0.1 -0.5 -0.3 -0.8 0.0 -0.2
Pulse wave reflection index 0.2 0.2 0.4 -0.6 0.5 0.3 0.0 0.0 0.7
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.4 0.0 1.2 0.6 1.6 -0.7 0.3
Loud music exposure frequency 0.3 0.3 0.7 0.5 0.7 0.8 0.5 -0.2 -0.5
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.9 0.1 0.7 0.8 0.4 -1.0 0.7
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 4.2 -0.6 -0.7 -0.8 -1.1 1.4 -2.1
Blood clot in the leg (DVT) 0.1 0.1 0.4 -0.3 0.0 0.2 -0.6 0.5 0.1
Medication: Paracetamol 0.1 0.1 0.3 0.5 0.3 0.5 0.3 -0.1 -0.1
Headache pain in last month 1.9 3.2 4.5 1.6 1.6 1.8 1.5 -2.1 2.1
Medication for cholesterol, blood pressure or diabetes 2.7 4.5 7.8 1.9 1.9 2.4 1.3 -2.1 2.8
Glaucoma (self-reported) 0.3 0.4 1.2 0.3 0.5 0.7 0.3 -1.1 -0.4
Gout (self-reported) 4.6 6.3 9.4 -2.4 -3.1 -2.6 -3.0 2.6 -0.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.1 -0.6 0.0 -0.6 0.1 0.0 -1.1
Medication: Amlodipine 1.4 1.9 3.7 -0.6 -1.4 -1.6 -1.4 1.1 -1.9
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 0.6 0.0 -0.6 -0.2 -0.1 0.0
Birth weight 0.4 0.8 2.0 -1.1 -0.7 -0.8 -0.6 0.3 1.4
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 -0.7 -0.3 -0.2 -0.3 0.6 -0.7
High blood pressure (siblings) 0.8 1.1 1.8 -0.7 -1.3 -1.2 -0.8 1.1 -1.0
Forced vital capacity (FVC), Best measure 0.2 0.9 2.5 -1.0 -1.1 -0.6 -1.6 0.5 -0.1
Body fat percentage 0.2 0.6 1.3 0.4 0.9 0.9 1.1 -0.8 0.3
Leg fat percentage (right) 0.3 1.0 2.0 0.7 1.0 1.4 1.4 -1.0 0.2
Arm fat-free mass (right) 0.3 1.5 3.4 -1.8 -1.4 -1.1 -1.4 0.7 0.5
Exposure to tobacco smoke outside home 1.8 2.4 6.3 0.2 1.2 1.2 1.1 -2.0 2.5
Comparative body size at age 10 0.1 0.3 1.0 -0.4 -0.7 -0.1 -1.0 0.2 0.4
Number of full brothers 0.6 0.7 1.6 -1.3 -0.3 -1.0 -0.5 0.5 -1.1
Worry too long after embarrassment 0.1 0.2 0.8 -0.0 -0.3 -0.1 -0.1 0.9 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 0.7 0.3 0.3 0.4 0.1 -0.5
Wheeze or whistling in the chest in last year 0.2 0.4 1.2 0.7 0.4 -0.5 1.1 0.1 -0.3
Number of children fathered 0.5 0.6 1.6 -1.3 -0.5 -0.2 -0.7 0.1 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.8 0.5 -0.1 0.6 -0.2 -0.5 0.9
Age at first live birth 1.9 3.4 7.4 1.7 1.8 1.5 1.2 -1.8 2.7
Pulse wave peak to peak time 0.2 0.2 0.7 0.8 -0.0 -0.1 0.1 -0.3 0.7
Health satisfaction 1.1 1.4 2.7 1.5 1.4 0.8 1.6 -0.8 0.0
Shortness of breath walking on level ground 0.2 0.3 0.8 0.3 0.9 -0.1 0.9 -0.1 -0.1
Qualifications: College or University degree 0.8 2.4 5.1 2.3 1.2 1.7 0.5 -1.1 1.9
Eye problems/disorders: None of the above 0.2 0.3 1.3 -1.1 -0.2 -0.3 -0.5 -0.1 0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.9 -0.9 -0.7 -0.9 -0.8 0.8 -0.5
Emphysema/chronic bronchitis 1.1 1.2 2.7 1.1 1.4 0.9 1.6 -0.7 -0.5
Medication for pain relief, constipation, heartburn 0.3 0.4 1.6 0.3 0.4 0.4 0.3 -0.7 1.3
Neck or shoulder pain in last month 0.6 0.9 2.1 0.6 0.8 0.9 0.9 -0.9 1.4
Medication: Blood pressure 1.7 2.9 7.2 -1.1 -1.5 -2.0 -0.6 1.7 -2.7
Angina (self-reported) 1.3 1.6 2.3 -1.5 -1.2 -1.5 -0.7 1.2 -1.4
Migraine (self-reported) 0.8 1.0 1.9 0.2 0.9 1.1 1.1 -1.4 0.9
Medication: Ibuprofen 0.6 0.8 2.6 0.3 0.4 0.6 0.5 -1.1 1.6
Medication: Allopurinol 6.3 8.3 13.2 -2.5 -3.6 -3.1 -3.3 3.1 -0.7
Medication: Omeprazole 0.2 0.2 0.5 -0.3 -0.1 -0.7 -0.5 0.4 -0.4
Medication: Seretide 50 evohaler 0.8 0.9 1.6 1.3 1.0 1.1 1.1 -0.6 -0.4
Mean time to correctly identify matches 0.5 1.0 2.1 -1.4 -0.5 -0.6 -1.4 0.4 -1.0
Heart disease (mother) 1.6 2.0 3.7 -1.1 -1.5 -1.9 -1.0 1.5 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.8 -0.9 -0.5 -0.9 -0.9 0.1 -0.0
Whole body fat mass 0.1 0.2 0.3 -0.2 0.5 0.6 0.6 -0.6 0.5
Leg fat mass (right) 0.1 0.2 0.5 -0.1 0.3 0.7 0.6 -0.3 0.2
Arm predicted mass (right) 0.3 1.5 3.2 -1.8 -1.3 -1.1 -1.5 0.7 0.5
Pulse rate, automated reading 0.5 1.7 4.1 -1.8 -0.9 -0.5 -1.3 0.4 -2.0
Alcohol intake frequency. 0.1 0.2 0.7 0.5 0.1 -0.8 0.3 0.1 -0.4
Comparative height size at age 10 1.5 8.1 16.0 -4.0 -2.5 -3.6 -2.7 2.2 -0.8
Number of full sisters 0.5 0.6 2.0 -1.4 -0.7 -0.2 -0.8 0.0 -0.6
Suffer from ‘nerves’ 1.2 1.8 2.9 -1.6 -1.5 -0.6 -1.7 1.5 -0.7
Overall health rating 0.1 0.3 0.6 0.8 0.1 0.6 0.4 0.1 -0.8
Chest pain or discomfort 0.2 0.3 0.8 0.9 -0.1 0.0 0.3 0.2 -0.9
Had major operations 0.3 0.4 1.1 0.3 0.5 1.1 0.1 -0.9 0.1
Age at last live birth 1.4 2.1 5.9 1.3 1.2 1.3 0.6 -1.3 2.4
Family relationship satisfaction 0.5 0.7 2.3 1.5 0.2 1.2 0.0 -0.3 0.3
Leg pain on walking 2.6 3.3 5.0 1.9 2.2 1.9 2.1 -1.5 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.7 -1.3 -0.8 -0.0 -0.9 -0.2 0.1
Commuting to job workplace: Car/motor vehicle 1.2 1.3 2.3 1.4 1.0 1.4 1.5 -0.7 -0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 -0.8 -0.7 -0.4 -0.4 0.4 -0.5
Medication: Aspirin 3.6 4.7 6.9 -2.2 -1.9 -2.2 -1.9 2.0 -2.6
Supplements: Vitamin C 1.3 1.5 2.6 -1.6 -1.2 -1.3 -1.6 0.9 -0.2
Knee pain experienced in last month 0.5 0.8 1.4 0.7 0.8 1.2 1.1 -0.9 0.7
Hypertension (Self-reported) 3.6 9.9 13.9 -2.8 -3.1 -3.7 -3.0 3.3 -2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.3 0.9 1.0 0.5 1.1 -1.0 0.5
Illnesses of father: Heart disease 0.9 1.2 3.4 1.8 1.1 0.4 0.8 -0.8 1.1
Illnesses of siblings: Diabetes 0.2 0.3 0.6 -0.7 -0.5 0.2 -0.4 -0.3 -0.8
Smoking status: Previous 0.2 0.3 0.6 0.3 0.6 0.5 0.6 -0.8 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.0 0.3 -0.2 -0.5 -0.4 0.2 1.0
Whole body fat-free mass 0.3 1.4 3.4 -1.8 -1.2 -1.3 -1.2 0.8 0.3
Leg fat-free mass (right) 0.1 0.6 1.4 -1.2 -0.7 -0.6 -0.5 0.6 0.7
Arm fat percentage (left) 0.3 1.2 2.3 0.5 1.2 1.4 1.5 -0.9 0.7
Average weekly red wine intake 1.9 2.8 3.4 -1.4 -1.8 -1.8 -1.5 1.8 -1.6
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 0.7 0.1 0.6 -0.1 -0.5 0.3
Mood swings 0.2 0.3 1.1 -0.1 -0.5 -0.3 0.1 1.1 -0.5
Loneliness, isolation 0.6 0.8 1.5 1.2 0.8 1.1 0.9 -0.5 0.8
Long-standing illness, disability or infirmity 0.3 0.5 1.4 0.7 0.6 0.0 1.2 0.2 -0.8
Ever had bowel cancer screening 0.1 0.1 0.5 -0.3 0.0 0.0 0.2 -0.7 -0.3
Diabetes diagnosed by doctor 3.0 4.9 10.0 -2.4 -1.7 -2.1 -1.4 2.0 -3.2
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.8 -0.8 -0.5 -1.3 -0.2 0.7 -0.8
Friendships satisfaction 0.3 0.4 1.2 0.9 0.5 1.1 0.0 -0.2 0.0
Qualifications: nursing, teaching 0.2 0.4 0.6 0.6 0.7 0.6 0.8 -0.4 0.5
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.3 0.4 0.1 0.3 -0.4 -0.2
Eye problems/disorders: Cataract 0.9 1.0 2.7 -0.3 -1.0 -1.4 -0.5 1.6 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.3 -0.2 0.4 -0.5 0.6 0.2 -1.2
Medication for cholesterol 5.6 8.5 11.3 2.5 2.8 3.1 2.6 -3.1 3.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 1.7 -1.1 -1.1 -0.3 -0.7 1.3 -1.3
Back pain experienced in last month 2.1 3.1 5.1 2.3 1.4 2.1 1.9 -1.3 1.2
Mineral and other dietary supplements 2.3 3.1 5.2 -1.3 -1.9 -2.3 -1.5 1.8 -1.5
Breast cancer (self-reported) 0.6 0.7 1.1 -0.9 -0.5 -0.6 -0.8 1.0 -0.9
Asthma (self-reported) 0.2 0.4 0.8 0.8 0.9 0.2 0.9 -0.5 -0.2
Osteoporosis (self-reported) 0.8 1.0 3.4 1.9 1.1 -0.2 0.9 -0.5 -0.2
Osteoarthritis (self-reported) 1.8 2.3 3.5 1.0 1.4 1.9 1.6 -1.9 1.2
Medication: Aspirin 4.4 5.7 6.7 -2.5 -2.2 -2.6 -2.3 2.2 -2.5
Medication: Gliclazide 0.8 0.9 2.4 -1.6 -0.7 -0.7 -0.7 0.4 -1.0
Illnesses of father: None of the above (group 1) 0.1 0.2 0.2 -0.4 0.5 0.5 0.4 -0.4 -0.0
Smoking status: Current 1.1 1.7 3.2 0.8 1.5 1.4 1.8 -1.2 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.0 -0.7 -0.6 0.4 -1.0 0.4 0.1
Whole body water mass 0.2 1.3 3.2 -1.8 -1.1 -1.2 -1.1 0.7 0.4
Leg predicted mass (right) 0.1 0.6 1.3 -1.2 -0.7 -0.6 -0.5 0.6 0.7
Arm fat mass (left) 0.1 0.6 1.1 -0.0 0.8 0.9 1.0 -0.6 0.7
Number of self-reported non-cancer illnesses 0.5 0.9 2.1 -0.9 -0.7 -1.2 -0.5 0.6 -1.5
Average weekly champagne plus white wine intake 0.3 0.4 1.3 -1.1 -0.3 -0.4 -0.8 0.2 0.2
Miserableness 0.7 1.2 2.2 -0.8 -1.1 -0.7 -0.7 1.5 -1.4
Guilty feelings 0.2 0.3 0.7 0.5 0.5 0.2 0.6 -0.2 0.8
Wears glasses or contact lenses 0.1 0.1 0.2 -0.4 0.0 -0.2 -0.3 0.0 -0.2
Ever taken oral contraceptive pill 1.4 1.5 3.7 0.9 1.0 1.9 1.3 -1.3 0.6
Hearing aid user 0.3 0.3 0.8 0.4 0.6 0.4 0.7 -0.9 0.3
Mother’s age at death 0.6 0.8 2.6 0.8 0.6 0.6 0.8 -0.5 1.6
Financial situation satisfaction 0.7 0.9 1.8 0.9 1.4 0.7 1.0 -1.2 -0.2
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.1 0.6 0.4 1.0 0.2 -0.2 0.1
Commuting to job workplace: Public transport 0.4 0.5 1.6 1.3 0.6 -0.2 0.4 -0.3 0.9
Eye problems/disorders: Glaucoma 0.2 0.3 0.7 0.6 0.3 0.7 0.3 -0.8 0.2
Medication: Blood pressure 6.8 12.9 14.2 -3.5 -3.7 -3.8 -3.7 3.8 -3.1
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 -0.7 0.1 -0.9 0.4 -0.2 -0.2
Supplements: Fish oil (including cod liver oil) 2.0 2.6 5.1 1.1 1.6 2.3 1.5 -1.8 1.2
High cholesterol (Self-reported) 5.5 9.7 14.4 -3.1 -2.9 -3.8 -2.6 3.0 -3.2
Medication: Bendroflumethiazide 6.2 9.4 12.3 -3.2 -2.9 -3.2 -2.8 2.8 -3.5
Medication: Paracetamol 0.1 0.2 0.4 0.6 0.4 0.4 0.3 -0.2 0.6
Medication: Lisinopril 1.6 2.0 3.0 -1.0 -1.6 -1.7 -1.2 1.4 -1.5
Medication: Atorvastatin 0.9 1.1 3.0 -1.2 -0.7 -1.7 -0.5 0.9 -0.8
Illnesses of father: High blood pressure 1.2 1.5 2.2 -0.4 -1.4 -1.5 -0.9 1.4 -1.5
Alcohol drinker status: Never 0.4 0.5 1.1 0.3 0.8 0.2 0.5 -1.0 0.9
Ever smoked 1.3 2.3 4.1 -2.0 -1.3 -1.2 -1.2 1.4 -1.7
Basal metabolic rate 0.2 1.0 2.6 -1.6 -1.0 -1.0 -0.9 0.6 0.5
Leg fat percentage (left) 0.2 0.5 1.3 0.5 0.7 1.1 1.0 -0.6 0.2
Arm fat-free mass (left) 0.3 1.3 3.1 -1.8 -1.2 -1.1 -1.1 0.7 0.4
Number of operations (self-reported) 0.5 0.7 1.1 1.1 0.9 0.8 1.0 -0.8 0.2
Average weekly beer plus cider intake 0.3 0.5 1.1 0.9 0.3 1.0 0.3 -0.8 0.5
Irritability 2.2 3.7 7.1 2.1 2.0 1.8 2.7 -1.6 0.9
Risk taking 1.4 2.0 3.8 1.9 1.3 1.0 2.0 -1.0 1.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 -0.2 0.5 0.3 0.2 -0.7 -0.0
Fractured/broken bones in last 5 years 0.5 0.7 2.0 0.1 0.6 0.8 0.2 -1.0 1.4
Age started oral contraceptive pill 0.6 0.7 1.1 0.9 1.0 0.7 0.6 -1.0 0.8
Diastolic blood pressure, automated reading 1.2 3.6 5.7 -2.4 -1.7 -2.0 -1.9 1.6 -1.6
Ever depressed for a whole week 0.7 0.8 1.4 -1.1 -0.8 -1.2 -0.7 1.1 -0.2
Unable to work because of sickness or disability 0.8 1.1 1.4 0.9 1.2 1.2 1.2 -1.0 0.8
Commuting to job workplace: Cycle 0.2 0.2 0.4 0.0 -0.4 -0.6 -0.4 0.2 -0.6
Myopia 0.5 0.7 1.7 1.3 0.8 0.9 0.6 -0.8 0.3
Vascular/heart problems diagnosed by doctor 4.6 12.6 18.7 3.0 3.7 4.3 3.2 -3.8 3.0
Cholesterol lowering medication 7.0 10.3 13.5 -3.2 -2.9 -3.7 -2.9 3.2 -3.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.3 0.6 0.4 -0.6 0.1 -0.1 -0.4
Pain experienced in last month 0.2 0.4 1.2 -0.5 -0.3 -0.4 -0.7 0.4 -1.1
Supplements: Calcium 0.4 0.4 1.5 -0.4 -0.1 -0.8 -0.4 0.2 -1.2
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 -0.5 0.1 -0.2 0.2 -0.5 0.3
Heart attack/myocardial infarction (self-reported) 2.2 2.8 5.3 -1.6 -1.6 -2.3 -1.4 1.6 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.1 0.0 0.3 0.3 -0.3 0.3 0.2
Heart disease (siblings) 2.4 3.0 6.6 0.6 1.6 1.4 1.6 -1.9 2.6
Alcohol drinker status: Previous 2.4 2.7 3.8 -1.5 -1.5 -1.7 -1.6 1.5 -2.0
Pack years of smoking 0.4 0.6 1.6 -0.3 -0.1 -0.7 0.6 1.1 -1.3
Impedance of whole body 0.0 0.2 0.6 0.8 0.3 -0.3 0.1 -0.1 -0.5
Leg fat mass (left) 0.0 0.1 0.3 -0.2 0.1 0.5 0.4 -0.1 0.2
Arm predicted mass (left) 0.3 1.7 3.8 -2.0 -1.5 -1.3 -1.4 0.9 0.0