Hub : Genes

SLC9A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1760	0.0480	1.1e-06	0.092	NA	0.083	NA	0.079	4.0e-05	NA	9.2e-05	NA	1.3e-04
2	GTEx	Heart Left Ventricle	0.0919	0.0399	1.6e-03	0.082	NA	0.022	NA	0.071	3.7e-05	NA	2.4e-02	NA	1.2e-04
3	GTEx	Testis	0.1370	0.0660	7.3e-03	0.086	NA	0.095	NA	0.094	1.1e-04	NA	5.3e-05	NA	5.8e-05
4	GTEx	Thyroid	0.1000	0.0460	6.4e-03	0.050	NA	0.021	NA	0.045	1.1e-04	NA	8.8e-03	NA	2.2e-04
5	METSIM	Adipose	0.0531	0.0211	2.0e-05	0.067	0.033	0.059	0.046	0.060	3.2e-10	7.6e-06	3.2e-09	1.9e-07	2.3e-09
6	TCGA	Prostate Adenocarcinoma	0.1055	0.0394	1.0e-09	0.040	0.078	0.102	NA	0.107	4.5e-05	1.5e-08	9.3e-11	NA	3.0e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.0	0.0	0.1	0.3	0.0	0.1	-0.0	-0.2	0.2
Bipolar Disorder or Schizophrenia	0.9	2.2	3.5	1.1	1.8	1.7	1.3	-1.9	0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.5	0.3	0.3	0.6	0.3	-0.1
Depression (Nagel 2018)	0.4	0.7	1.2	1.1	0.9	0.4	0.8	-0.4	0.9
Intelligence (Savage-Jansen 2018)	1.0	3.0	3.9	1.5	2.0	1.9	1.6	-1.7	1.6
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.1	0.1	0.4	0.4	0.4	0.0
Schizophrenia (2018)	1.6	3.3	5.3	1.2	2.3	2.0	1.7	-2.3	0.9
Schizophrenia vs Biploar Disorder	0.3	0.3	1.0	-0.7	0.0	-0.2	-0.3	0.6	-1.0
Worry (Nagel 2018)	0.8	1.7	3.0	-1.7	-1.3	-0.4	-1.7	1.4	-1.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	0.9	0.5	0.4	0.6	0.1	-0.6
Alzheimer’s Disease (in father)	2.1	2.3	3.5	-1.3	-1.5	-1.4	-1.5	1.5	-1.9
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	-0.2	-0.6	-0.6	-0.4	0.8	-1.4
Crohns Disease (2017)	0.1	0.1	0.3	0.2	0.2	-0.1	0.6	-0.0	-0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.4	0.2	-0.5	0.5	-0.2	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.7	0.1	-0.7	0.2	-0.3	0.1
Major Depression (MDD)	1.7	2.1	2.9	1.6	1.6	1.7	1.5	-1.5	0.0
Reaction Time	0.5	0.9	2.2	-1.3	-0.8	-0.4	-1.5	0.5	-0.6
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.5	-0.7	-0.2	-0.1	-0.1	0.2	0.2
Breast Cancer	0.6	1.4	3.1	-0.6	-1.2	-1.8	-0.6	1.2	-1.3
Ovarian Cancer	0.7	0.9	2.6	-0.9	-0.8	-1.0	-0.7	1.6	0.2
Prostate Cancer	2.0	2.8	4.6	0.8	1.8	1.8	1.9	-2.1	1.3
Age at First Birth	2.4	3.5	5.0	2.2	2.2	1.6	2.1	-1.9	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.4	2.5	1.2	1.3	0.8	1.6	-1.1	1.1
Coronary Artery Disease (CAD)	0.1	0.2	1.0	0.0	0.0	0.0	0.0	1.0	0.0
Crohns Disease (2012)	0.1	0.1	0.5	0.1	0.5	0.2	0.7	-0.4	-0.0
Mean Putamen Volume	0.2	0.2	0.4	0.4	0.3	-0.4	0.2	-0.6	0.6
Fasting Glucose	0.2	0.2	0.7	0.2	0.4	0.1	0.4	-0.4	-0.8
HbA1C	0.1	0.1	0.3	0.0	0.4	0.5	-0.1	-0.5	0.1
HDL Cholesterol	1.0	1.6	4.6	1.7	0.8	2.1	0.4	-0.9	0.8
LDL Cholesterol	0.6	0.9	2.5	-0.3	-0.8	-0.8	-0.4	1.2	-1.6
Lupus	0.6	0.9	2.2	-1.4	-1.1	-0.6	-1.5	0.1	-0.4
Neuroticism (2016)	0.6	0.8	2.3	-0.4	-1.0	-0.6	-0.6	1.5	-0.8
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.4	0.3	0.2	0.3	-0.4	0.6
Rheumatoid Arthritis	0.1	0.2	0.5	-0.1	-0.3	-0.3	-0.7	0.3	0.4
Schizophrenia (2014)	1.3	2.8	4.5	1.0	2.0	2.0	1.4	-2.1	1.0
Triglycerides	0.1	0.2	0.5	-0.6	0.4	-0.1	0.7	0.1	-0.6
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.2	0.8	-0.9	0.3	-0.2	0.1	-0.6	-0.0
Blood Eosinophil Count	0.9	6.9	9.9	-2.1	-2.7	-3.1	-2.5	2.6	-2.6
Blood Platelet Count	0.8	9.3	15.5	-3.2	-3.3	-3.9	-2.8	2.9	-1.9
Blood Red Count	0.0	0.0	0.2	-0.1	-0.3	-0.4	-0.1	0.0	-0.1
Blood White Count	0.1	0.7	1.9	1.4	0.3	1.0	0.6	-0.9	0.6
Heel T-Score	0.3	2.4	4.8	1.3	1.3	2.2	0.9	-1.6	1.6
BMI	0.1	0.5	1.2	-0.0	0.6	0.9	1.1	-0.4	0.6
Height	0.5	9.7	16.7	-4.0	-3.3	-3.4	-4.1	1.8	-0.1
Waist Hip Ratio (WHR)	0.2	0.9	2.1	0.3	1.4	1.0	1.1	-0.9	0.5
Systolic Blood Pressure	4.5	22.3	29.3	-4.7	-4.9	-5.4	-5.2	4.5	-3.5
Smoking Status	1.0	2.3	4.7	1.3	1.6	1.8	2.2	-1.1	0.7
Allergy or Eczema	0.3	0.9	2.8	1.2	0.2	0.4	0.9	0.3	-1.7
Cardiovascular Disease	4.5	14.8	19.1	-3.2	-3.9	-4.4	-3.5	4.3	-3.6
Hypothyroidism (self reported)	0.2	0.4	1.1	-0.4	0.5	-0.4	0.8	0.0	-1.1
Respiratory disease	0.3	0.8	1.6	1.0	0.8	-0.0	1.2	-0.1	-1.3
Type 2 Diabetes (T2D) (2018)	0.9	1.6	5.2	-1.2	-0.7	-1.1	-0.2	1.2	-2.3
Lung FEV1/FVC ratio	0.2	0.8	1.5	0.2	1.0	1.0	0.9	-0.9	1.2
Lung FVC	0.3	1.6	2.4	1.1	1.4	1.4	0.7	-1.5	1.2
Neuroticism	0.0	0.1	0.3	-0.2	-0.0	-0.0	-0.2	0.5	-0.4
Chronotype (morning person)	2.4	5.6	7.9	-2.0	-2.8	-2.2	-2.8	2.2	-2.0
Hair Pigment	0.1	2.3	5.2	1.2	1.6	0.9	1.4	-1.4	2.3
Tanning	0.0	0.6	1.4	-0.7	-0.8	-0.8	-0.5	0.1	-1.2
Hand grip strength (left)	0.1	0.4	1.0	-0.6	-0.8	-0.4	-1.0	0.2	0.3
Number of treatments/medications taken	0.0	0.1	0.1	-0.3	0.0	-0.3	0.2	0.2	-0.2
Average weekly spirits intake	0.2	0.2	0.4	0.6	-0.2	-0.2	0.3	0.5	0.6
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.8	-0.0	-0.1	0.1	0.6	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.7	0.5	0.4	0.3	-0.2	0.8
Hearing difficulty/problems: Yes	3.6	5.5	6.1	2.4	2.4	2.4	2.5	-2.3	2.1
Relative age of first facial hair	0.1	0.1	0.2	-0.5	-0.3	0.4	-0.4	-0.3	0.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.0	1.5	1.7	1.0	1.5	-1.3	0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	-0.3	-0.6	0.1	-0.2	0.3	-0.6
Ever had hysterectomy (womb removed)	1.5	1.7	2.4	1.6	1.3	1.4	1.0	-1.3	1.2
Systolic blood pressure, automated reading	2.7	7.9	11.3	-3.0	-2.8	-3.4	-3.1	2.6	-1.7
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	6.0	-1.8	-1.8	-2.4	-1.2	2.2	-1.1
Angina	1.2	1.5	2.2	-1.5	-1.2	-1.4	-0.7	1.2	-1.3
Medication for hormone replacement therapy	0.5	0.6	3.1	0.2	-0.3	0.1	-0.0	0.5	-1.8
Vitamin and mineral supplements	0.3	0.4	2.1	-0.0	-0.5	-0.0	-0.3	0.2	-1.5
Supplements: Zinc	1.4	1.5	2.9	-1.5	-1.4	-1.0	-1.7	0.9	0.2
Medication: Co-codamol	1.6	1.9	3.1	0.9	1.3	1.8	1.3	-1.5	1.2
Medication: Metformin	3.6	5.1	7.4	-2.5	-2.2	-2.1	-1.8	2.0	-2.7
Diabetes (father)	0.7	0.8	1.8	-0.7	-1.0	-0.5	-1.3	1.1	-0.4
Diabetes (mother)	9.1	11.6	14.5	-3.8	-3.5	-3.2	-3.6	3.0	-3.2
Severe depression (siblings)	0.1	0.1	0.6	0.0	0.1	0.3	-0.3	0.0	-0.7
Pack years adult smoking proportion	0.3	0.4	1.2	0.1	0.2	-0.3	0.8	0.8	-1.1
Impedance of leg (right)	0.1	0.6	1.8	0.1	-0.6	-1.0	-0.7	0.4	-1.3
Leg fat-free mass (left)	0.1	0.4	1.1	-1.1	-0.5	-0.4	-0.2	0.3	0.7
Trunk fat percentage	0.2	0.7	1.4	0.5	1.0	0.8	1.2	-0.8	0.6
Hand grip strength (right)	0.1	0.4	1.0	-0.2	-0.8	-0.1	-1.0	-0.0	0.8
Townsend deprivation index at recruitment	0.4	0.6	2.2	-0.9	-0.1	-0.5	0.4	0.7	-1.5
Current tobacco smoking	1.0	1.6	2.9	0.8	1.4	1.5	1.7	-1.0	0.8
Average weekly fortified wine intake	0.4	0.4	0.9	-0.5	0.7	0.7	0.6	-1.0	0.3
Maternal smoking around birth	0.7	1.0	1.8	0.8	1.2	1.0	1.3	-0.9	0.6
Fed-up feelings	0.2	0.3	1.1	0.1	-0.2	-0.4	0.3	1.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.5	0.2	-0.2	0.1	0.3	0.2
Relative age voice broke	0.5	0.7	1.8	0.5	0.5	1.3	-0.2	-1.1	1.0
Taking other prescription medications	0.7	1.1	1.7	0.9	1.2	0.7	1.3	-1.2	0.9
Age when periods started (menarche)	1.1	2.5	4.5	1.0	1.7	1.7	1.2	-2.1	1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.9	-1.1	-1.0	-1.4	-0.9	1.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	5.9	-1.4	-1.9	-0.9	-2.4	1.7	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.3	-0.0	-0.5	-0.0	-0.3	-0.2
Qualifications: CSEs or equivalent	1.1	1.4	2.0	1.3	1.4	1.1	1.2	-0.9	1.0
Serious illness, injury or assault to yourself	3.8	4.6	7.8	2.2	2.8	1.7	2.2	-2.1	1.6
High blood pressure	4.0	11.2	16.2	-2.9	-3.4	-4.0	-3.1	3.5	-3.0
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.7	0.9	-0.3	-0.2	0.5	1.2	-2.2
Multivitamins +/- minerals	1.3	1.6	4.7	0.7	1.5	0.8	1.0	-0.9	2.2
Stomach or abdominal pain in last month	0.9	1.1	4.3	1.1	0.5	0.9	0.2	-0.4	2.1
Supplements: Glucosamine	3.8	4.9	7.3	1.4	2.1	2.5	1.7	-2.7	2.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	1.3	0.7	0.4	0.9	-0.8	0.5
Medication: Atenolol	3.1	3.9	6.9	-1.6	-1.8	-2.6	-1.5	2.3	-1.8
Medication: Levothyroxine sodium	0.3	0.6	1.1	0.7	0.9	0.4	1.0	-0.8	0.0
Sitting height	0.7	4.7	8.4	-1.8	-2.5	-2.9	-2.7	1.8	-0.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.1	0.7	0.6	0.6	-0.3	-0.1
High blood pressure (mother)	4.2	5.9	7.6	-2.5	-2.7	-2.8	-2.4	2.7	-1.0
Body mass index (BMI)	0.1	0.5	1.1	0.1	0.6	1.0	1.0	-0.5	0.5
Impedance of leg (left)	0.2	1.1	2.2	-0.1	-0.9	-1.4	-1.1	0.8	-1.5
Leg predicted mass (left)	0.1	0.4	1.1	-1.1	-0.5	-0.3	-0.3	0.3	0.7
Trunk fat mass	0.1	0.4	0.5	-0.0	0.6	0.6	0.7	-0.6	0.7
Waist circumference	0.1	0.4	0.9	-0.3	0.7	0.5	0.9	-0.5	0.7
Number of incorrect matches in round	1.3	2.2	3.7	1.3	1.9	1.5	1.5	-1.5	1.2
Past tobacco smoking	0.2	0.3	1.0	1.0	0.2	0.3	0.2	-0.2	0.8
Alcohol usually taken with meals	0.5	0.7	1.4	0.7	0.9	0.6	0.9	-1.2	0.7
Nervous feelings	1.0	1.8	3.8	-2.0	-1.3	-1.0	-1.7	1.2	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.2	-0.9	-1.5	-1.1	-1.4	1.8	-0.9
Hearing difficulty/problems with background noise	1.0	1.5	3.0	1.2	1.2	1.4	1.7	-0.9	0.7
Hair/balding pattern: Pattern 2	2.1	2.6	4.9	-0.6	-2.2	-1.2	-1.5	2.1	-1.5
Had menopause	1.2	1.5	2.6	1.0	1.1	1.5	0.3	-1.3	1.6
Had other major operations	0.7	0.8	1.8	1.3	1.0	0.5	1.3	-0.5	-0.1
Forced vital capacity (FVC)	0.3	1.0	2.2	-1.0	-1.1	-0.8	-1.5	0.8	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	4.0	-0.7	-1.6	-0.4	-2.0	1.2	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.2	-1.5	-0.4	-1.2	-0.5	0.8	-0.8
Qualifications: None of the above	0.9	2.0	2.9	-1.3	-1.2	-1.6	-1.0	1.5	-1.7
Financial difficulties in last 2 years	0.2	0.3	0.3	0.6	0.6	0.5	0.4	-0.6	0.5
Mouth/teeth dental problems	0.8	1.2	4.8	0.8	-0.2	0.7	-0.2	-0.9	2.2
Heart attack	1.9	2.4	4.8	-1.5	-1.5	-2.2	-1.3	1.5	-1.3
Allergy	0.4	0.9	4.1	-0.7	0.1	-0.1	-0.3	-0.9	2.0
Pain all over the body in last month	0.4	0.4	0.8	-0.9	-0.6	-0.6	-0.8	0.5	-0.4
Diabetes (self-reported)	2.7	4.2	8.2	-2.2	-1.6	-2.0	-1.3	2.0	-2.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.1	-0.2	-0.5	0.3	0.9	-1.1
Medication: Ramipril	1.9	2.5	4.0	-0.8	-1.6	-1.7	-1.2	2.0	-1.8
Medication: Simvastatin	3.6	5.2	6.1	-2.3	-2.2	-2.5	-2.3	2.2	-2.3
Fluid intelligence score	0.3	0.7	1.2	-0.7	-1.0	-0.2	-1.1	0.9	-0.6
Illnesses of siblings	0.2	0.3	0.7	-0.3	-0.5	-0.1	-0.8	0.6	-0.8
Neuroticism score	0.1	0.3	1.0	-0.6	-0.3	-0.2	-0.3	1.0	-0.1
Weight	0.0	0.2	0.9	-0.9	-0.3	-0.2	-0.1	-0.0	0.6
Impedance of arm (right)	0.1	0.4	0.7	0.8	0.9	-0.1	0.7	-0.4	-0.3
Arm fat percentage (right)	0.2	0.9	2.2	0.4	1.0	1.1	1.5	-0.7	0.4
Trunk fat-free mass	0.4	2.1	4.5	-2.1	-1.5	-1.6	-1.5	0.8	0.3
Hip circumference	0.0	0.2	0.5	0.0	0.2	0.2	0.5	-0.2	0.7
Time employed in main current job	0.1	0.1	0.2	-0.2	0.0	0.2	0.1	-0.3	0.5
Alcohol intake versus 10 years previously	0.8	1.2	3.2	-0.4	-1.8	-0.6	-1.4	1.0	-0.7
Father’s age at death	0.2	0.3	0.8	-0.2	-0.4	0.5	0.1	0.6	-0.9
Worrier / anxious feelings	0.2	0.4	1.0	-0.7	-0.6	0.2	-1.0	0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.4	1.2	1.1	1.2	0.5	-0.7	1.1
Falls in the last year	1.9	2.6	3.9	1.7	1.9	1.7	1.3	-2.0	0.9
Hair/balding pattern: Pattern 3	0.6	0.9	1.9	0.4	1.2	1.4	0.9	-0.8	0.4
Number of live births	0.1	0.2	0.5	-0.7	0.1	0.1	-0.5	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.4	-0.9	-1.2	-0.9	-1.5	0.9	-0.3
Pulse rate	0.8	1.3	6.0	-0.3	-0.9	-0.2	-0.7	0.6	-2.5
Happiness	1.9	2.3	3.7	1.9	1.6	1.8	1.1	-1.1	1.3
Noisy workplace	0.7	0.8	1.5	0.5	1.0	1.0	1.1	-1.2	0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	1.9	1.2	1.4	1.3	0.8	-1.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	3.2	-1.5	-1.1	-1.8	-1.3	1.3	-1.6
Mouth/teeth dental problems: Dentures	0.4	0.6	1.5	-1.2	0.1	-0.6	0.4	0.3	-1.2
Asthma	0.1	0.3	0.5	0.7	0.7	0.2	0.6	-0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.5	0.5	0.7	0.9	0.8	-1.2	1.1
Medication: Cholesterol lowering	3.0	4.7	6.7	-2.4	-1.9	-2.6	-1.7	2.0	-2.3
Depression (self-reported)	0.3	0.3	1.1	-0.6	0.3	0.3	-0.2	-1.1	0.6
Medication: Lansoprazole	1.0	1.1	1.7	0.6	1.1	1.3	1.0	-1.3	1.0
Prospective memory result	0.4	0.5	0.9	0.1	0.6	0.9	0.7	-0.9	0.6
Lung cancer (father)	1.1	1.3	2.5	-1.5	-0.7	-1.6	-0.8	1.2	-0.7
Illnesses of mother	6.0	7.4	11.6	2.8	2.8	3.4	2.2	-3.0	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.5	-1.0	-1.4	-0.9	-1.9	0.8	0.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-1.2	-0.3	-0.2	-0.4	0.6	-0.9
Impedance of arm (left)	0.2	0.8	1.7	1.2	1.3	0.3	1.0	-0.9	0.2
Arm fat mass (right)	0.1	0.3	0.7	-0.2	0.5	0.7	0.8	-0.4	0.4
Trunk predicted mass	0.3	1.9	4.2	-2.1	-1.5	-1.6	-1.5	0.8	0.3
Standing height	0.3	3.3	6.1	-2.1	-1.8	-2.5	-2.3	0.8	0.5
Length of working week for main job	2.1	2.3	3.2	-1.3	-1.8	-1.6	-1.8	1.3	-1.3
Exposure to tobacco smoke at home	1.2	1.4	3.5	-1.4	-0.8	-0.8	-1.1	0.4	-1.9
Breastfed as a baby	0.4	0.5	2.0	0.3	-0.5	-0.3	-0.8	-0.2	1.4
Tense / ‘highly strung’	0.4	0.7	1.2	-0.9	-0.7	-0.3	-0.6	1.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	4.2	1.6	1.9	2.1	2.0	-1.7	0.9
Hair/balding pattern: Pattern 4	0.1	0.2	1.1	-0.3	-0.2	0.1	-0.2	0.1	-1.0
Birth weight of first child	5.7	10.3	13.8	-2.7	-3.7	-3.3	-3.6	3.5	-2.2
Peak expiratory flow (PEF)	0.1	0.2	0.7	0.1	-0.5	-0.3	-0.8	0.0	-0.2
Pulse wave reflection index	0.2	0.2	0.4	-0.6	0.5	0.3	0.0	0.0	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.4	0.0	1.2	0.6	1.6	-0.7	0.3
Loud music exposure frequency	0.3	0.3	0.7	0.5	0.7	0.8	0.5	-0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	0.1	0.7	0.8	0.4	-1.0	0.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	4.2	-0.6	-0.7	-0.8	-1.1	1.4	-2.1
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.3	0.0	0.2	-0.6	0.5	0.1
Medication: Paracetamol	0.1	0.1	0.3	0.5	0.3	0.5	0.3	-0.1	-0.1
Headache pain in last month	1.9	3.2	4.5	1.6	1.6	1.8	1.5	-2.1	2.1
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	7.8	1.9	1.9	2.4	1.3	-2.1	2.8
Glaucoma (self-reported)	0.3	0.4	1.2	0.3	0.5	0.7	0.3	-1.1	-0.4
Gout (self-reported)	4.6	6.3	9.4	-2.4	-3.1	-2.6	-3.0	2.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.1	-0.6	0.0	-0.6	0.1	0.0	-1.1
Medication: Amlodipine	1.4	1.9	3.7	-0.6	-1.4	-1.6	-1.4	1.1	-1.9
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.6	0.0	-0.6	-0.2	-0.1	0.0
Birth weight	0.4	0.8	2.0	-1.1	-0.7	-0.8	-0.6	0.3	1.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	-0.7	-0.3	-0.2	-0.3	0.6	-0.7
High blood pressure (siblings)	0.8	1.1	1.8	-0.7	-1.3	-1.2	-0.8	1.1	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.9	2.5	-1.0	-1.1	-0.6	-1.6	0.5	-0.1
Body fat percentage	0.2	0.6	1.3	0.4	0.9	0.9	1.1	-0.8	0.3
Leg fat percentage (right)	0.3	1.0	2.0	0.7	1.0	1.4	1.4	-1.0	0.2
Arm fat-free mass (right)	0.3	1.5	3.4	-1.8	-1.4	-1.1	-1.4	0.7	0.5
Exposure to tobacco smoke outside home	1.8	2.4	6.3	0.2	1.2	1.2	1.1	-2.0	2.5
Comparative body size at age 10	0.1	0.3	1.0	-0.4	-0.7	-0.1	-1.0	0.2	0.4
Number of full brothers	0.6	0.7	1.6	-1.3	-0.3	-1.0	-0.5	0.5	-1.1
Worry too long after embarrassment	0.1	0.2	0.8	-0.0	-0.3	-0.1	-0.1	0.9	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.7	0.3	0.3	0.4	0.1	-0.5
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.7	0.4	-0.5	1.1	0.1	-0.3
Number of children fathered	0.5	0.6	1.6	-1.3	-0.5	-0.2	-0.7	0.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.5	-0.1	0.6	-0.2	-0.5	0.9
Age at first live birth	1.9	3.4	7.4	1.7	1.8	1.5	1.2	-1.8	2.7
Pulse wave peak to peak time	0.2	0.2	0.7	0.8	-0.0	-0.1	0.1	-0.3	0.7
Health satisfaction	1.1	1.4	2.7	1.5	1.4	0.8	1.6	-0.8	0.0
Shortness of breath walking on level ground	0.2	0.3	0.8	0.3	0.9	-0.1	0.9	-0.1	-0.1
Qualifications: College or University degree	0.8	2.4	5.1	2.3	1.2	1.7	0.5	-1.1	1.9
Eye problems/disorders: None of the above	0.2	0.3	1.3	-1.1	-0.2	-0.3	-0.5	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-0.9	-0.7	-0.9	-0.8	0.8	-0.5
Emphysema/chronic bronchitis	1.1	1.2	2.7	1.1	1.4	0.9	1.6	-0.7	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.4	1.6	0.3	0.4	0.4	0.3	-0.7	1.3
Neck or shoulder pain in last month	0.6	0.9	2.1	0.6	0.8	0.9	0.9	-0.9	1.4
Medication: Blood pressure	1.7	2.9	7.2	-1.1	-1.5	-2.0	-0.6	1.7	-2.7
Angina (self-reported)	1.3	1.6	2.3	-1.5	-1.2	-1.5	-0.7	1.2	-1.4
Migraine (self-reported)	0.8	1.0	1.9	0.2	0.9	1.1	1.1	-1.4	0.9
Medication: Ibuprofen	0.6	0.8	2.6	0.3	0.4	0.6	0.5	-1.1	1.6
Medication: Allopurinol	6.3	8.3	13.2	-2.5	-3.6	-3.1	-3.3	3.1	-0.7
Medication: Omeprazole	0.2	0.2	0.5	-0.3	-0.1	-0.7	-0.5	0.4	-0.4
Medication: Seretide 50 evohaler	0.8	0.9	1.6	1.3	1.0	1.1	1.1	-0.6	-0.4
Mean time to correctly identify matches	0.5	1.0	2.1	-1.4	-0.5	-0.6	-1.4	0.4	-1.0
Heart disease (mother)	1.6	2.0	3.7	-1.1	-1.5	-1.9	-1.0	1.5	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.8	-0.9	-0.5	-0.9	-0.9	0.1	-0.0
Whole body fat mass	0.1	0.2	0.3	-0.2	0.5	0.6	0.6	-0.6	0.5
Leg fat mass (right)	0.1	0.2	0.5	-0.1	0.3	0.7	0.6	-0.3	0.2
Arm predicted mass (right)	0.3	1.5	3.2	-1.8	-1.3	-1.1	-1.5	0.7	0.5
Pulse rate, automated reading	0.5	1.7	4.1	-1.8	-0.9	-0.5	-1.3	0.4	-2.0
Alcohol intake frequency.	0.1	0.2	0.7	0.5	0.1	-0.8	0.3	0.1	-0.4
Comparative height size at age 10	1.5	8.1	16.0	-4.0	-2.5	-3.6	-2.7	2.2	-0.8
Number of full sisters	0.5	0.6	2.0	-1.4	-0.7	-0.2	-0.8	0.0	-0.6
Suffer from ‘nerves’	1.2	1.8	2.9	-1.6	-1.5	-0.6	-1.7	1.5	-0.7
Overall health rating	0.1	0.3	0.6	0.8	0.1	0.6	0.4	0.1	-0.8
Chest pain or discomfort	0.2	0.3	0.8	0.9	-0.1	0.0	0.3	0.2	-0.9
Had major operations	0.3	0.4	1.1	0.3	0.5	1.1	0.1	-0.9	0.1
Age at last live birth	1.4	2.1	5.9	1.3	1.2	1.3	0.6	-1.3	2.4
Family relationship satisfaction	0.5	0.7	2.3	1.5	0.2	1.2	0.0	-0.3	0.3
Leg pain on walking	2.6	3.3	5.0	1.9	2.2	1.9	2.1	-1.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.7	-1.3	-0.8	-0.0	-0.9	-0.2	0.1
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.3	1.4	1.0	1.4	1.5	-0.7	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	-0.8	-0.7	-0.4	-0.4	0.4	-0.5
Medication: Aspirin	3.6	4.7	6.9	-2.2	-1.9	-2.2	-1.9	2.0	-2.6
Supplements: Vitamin C	1.3	1.5	2.6	-1.6	-1.2	-1.3	-1.6	0.9	-0.2
Knee pain experienced in last month	0.5	0.8	1.4	0.7	0.8	1.2	1.1	-0.9	0.7
Hypertension (Self-reported)	3.6	9.9	13.9	-2.8	-3.1	-3.7	-3.0	3.3	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.3	0.9	1.0	0.5	1.1	-1.0	0.5
Illnesses of father: Heart disease	0.9	1.2	3.4	1.8	1.1	0.4	0.8	-0.8	1.1
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.7	-0.5	0.2	-0.4	-0.3	-0.8
Smoking status: Previous	0.2	0.3	0.6	0.3	0.6	0.5	0.6	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.0	0.3	-0.2	-0.5	-0.4	0.2	1.0
Whole body fat-free mass	0.3	1.4	3.4	-1.8	-1.2	-1.3	-1.2	0.8	0.3
Leg fat-free mass (right)	0.1	0.6	1.4	-1.2	-0.7	-0.6	-0.5	0.6	0.7
Arm fat percentage (left)	0.3	1.2	2.3	0.5	1.2	1.4	1.5	-0.9	0.7
Average weekly red wine intake	1.9	2.8	3.4	-1.4	-1.8	-1.8	-1.5	1.8	-1.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.7	0.1	0.6	-0.1	-0.5	0.3
Mood swings	0.2	0.3	1.1	-0.1	-0.5	-0.3	0.1	1.1	-0.5
Loneliness, isolation	0.6	0.8	1.5	1.2	0.8	1.1	0.9	-0.5	0.8
Long-standing illness, disability or infirmity	0.3	0.5	1.4	0.7	0.6	0.0	1.2	0.2	-0.8
Ever had bowel cancer screening	0.1	0.1	0.5	-0.3	0.0	0.0	0.2	-0.7	-0.3
Diabetes diagnosed by doctor	3.0	4.9	10.0	-2.4	-1.7	-2.1	-1.4	2.0	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.8	-0.8	-0.5	-1.3	-0.2	0.7	-0.8
Friendships satisfaction	0.3	0.4	1.2	0.9	0.5	1.1	0.0	-0.2	0.0
Qualifications: nursing, teaching	0.2	0.4	0.6	0.6	0.7	0.6	0.8	-0.4	0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.3	0.4	0.1	0.3	-0.4	-0.2
Eye problems/disorders: Cataract	0.9	1.0	2.7	-0.3	-1.0	-1.4	-0.5	1.6	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.3	-0.2	0.4	-0.5	0.6	0.2	-1.2
Medication for cholesterol	5.6	8.5	11.3	2.5	2.8	3.1	2.6	-3.1	3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.7	-1.1	-1.1	-0.3	-0.7	1.3	-1.3
Back pain experienced in last month	2.1	3.1	5.1	2.3	1.4	2.1	1.9	-1.3	1.2
Mineral and other dietary supplements	2.3	3.1	5.2	-1.3	-1.9	-2.3	-1.5	1.8	-1.5
Breast cancer (self-reported)	0.6	0.7	1.1	-0.9	-0.5	-0.6	-0.8	1.0	-0.9
Asthma (self-reported)	0.2	0.4	0.8	0.8	0.9	0.2	0.9	-0.5	-0.2
Osteoporosis (self-reported)	0.8	1.0	3.4	1.9	1.1	-0.2	0.9	-0.5	-0.2
Osteoarthritis (self-reported)	1.8	2.3	3.5	1.0	1.4	1.9	1.6	-1.9	1.2
Medication: Aspirin	4.4	5.7	6.7	-2.5	-2.2	-2.6	-2.3	2.2	-2.5
Medication: Gliclazide	0.8	0.9	2.4	-1.6	-0.7	-0.7	-0.7	0.4	-1.0
Illnesses of father: None of the above (group 1)	0.1	0.2	0.2	-0.4	0.5	0.5	0.4	-0.4	-0.0
Smoking status: Current	1.1	1.7	3.2	0.8	1.5	1.4	1.8	-1.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-0.7	-0.6	0.4	-1.0	0.4	0.1
Whole body water mass	0.2	1.3	3.2	-1.8	-1.1	-1.2	-1.1	0.7	0.4
Leg predicted mass (right)	0.1	0.6	1.3	-1.2	-0.7	-0.6	-0.5	0.6	0.7
Arm fat mass (left)	0.1	0.6	1.1	-0.0	0.8	0.9	1.0	-0.6	0.7
Number of self-reported non-cancer illnesses	0.5	0.9	2.1	-0.9	-0.7	-1.2	-0.5	0.6	-1.5
Average weekly champagne plus white wine intake	0.3	0.4	1.3	-1.1	-0.3	-0.4	-0.8	0.2	0.2
Miserableness	0.7	1.2	2.2	-0.8	-1.1	-0.7	-0.7	1.5	-1.4
Guilty feelings	0.2	0.3	0.7	0.5	0.5	0.2	0.6	-0.2	0.8
Wears glasses or contact lenses	0.1	0.1	0.2	-0.4	0.0	-0.2	-0.3	0.0	-0.2
Ever taken oral contraceptive pill	1.4	1.5	3.7	0.9	1.0	1.9	1.3	-1.3	0.6
Hearing aid user	0.3	0.3	0.8	0.4	0.6	0.4	0.7	-0.9	0.3
Mother’s age at death	0.6	0.8	2.6	0.8	0.6	0.6	0.8	-0.5	1.6
Financial situation satisfaction	0.7	0.9	1.8	0.9	1.4	0.7	1.0	-1.2	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.1	0.6	0.4	1.0	0.2	-0.2	0.1
Commuting to job workplace: Public transport	0.4	0.5	1.6	1.3	0.6	-0.2	0.4	-0.3	0.9
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.6	0.3	0.7	0.3	-0.8	0.2
Medication: Blood pressure	6.8	12.9	14.2	-3.5	-3.7	-3.8	-3.7	3.8	-3.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.7	0.1	-0.9	0.4	-0.2	-0.2
Supplements: Fish oil (including cod liver oil)	2.0	2.6	5.1	1.1	1.6	2.3	1.5	-1.8	1.2
High cholesterol (Self-reported)	5.5	9.7	14.4	-3.1	-2.9	-3.8	-2.6	3.0	-3.2
Medication: Bendroflumethiazide	6.2	9.4	12.3	-3.2	-2.9	-3.2	-2.8	2.8	-3.5
Medication: Paracetamol	0.1	0.2	0.4	0.6	0.4	0.4	0.3	-0.2	0.6
Medication: Lisinopril	1.6	2.0	3.0	-1.0	-1.6	-1.7	-1.2	1.4	-1.5
Medication: Atorvastatin	0.9	1.1	3.0	-1.2	-0.7	-1.7	-0.5	0.9	-0.8
Illnesses of father: High blood pressure	1.2	1.5	2.2	-0.4	-1.4	-1.5	-0.9	1.4	-1.5
Alcohol drinker status: Never	0.4	0.5	1.1	0.3	0.8	0.2	0.5	-1.0	0.9
Ever smoked	1.3	2.3	4.1	-2.0	-1.3	-1.2	-1.2	1.4	-1.7
Basal metabolic rate	0.2	1.0	2.6	-1.6	-1.0	-1.0	-0.9	0.6	0.5
Leg fat percentage (left)	0.2	0.5	1.3	0.5	0.7	1.1	1.0	-0.6	0.2
Arm fat-free mass (left)	0.3	1.3	3.1	-1.8	-1.2	-1.1	-1.1	0.7	0.4
Number of operations (self-reported)	0.5	0.7	1.1	1.1	0.9	0.8	1.0	-0.8	0.2
Average weekly beer plus cider intake	0.3	0.5	1.1	0.9	0.3	1.0	0.3	-0.8	0.5
Irritability	2.2	3.7	7.1	2.1	2.0	1.8	2.7	-1.6	0.9
Risk taking	1.4	2.0	3.8	1.9	1.3	1.0	2.0	-1.0	1.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.2	0.5	0.3	0.2	-0.7	-0.0
Fractured/broken bones in last 5 years	0.5	0.7	2.0	0.1	0.6	0.8	0.2	-1.0	1.4
Age started oral contraceptive pill	0.6	0.7	1.1	0.9	1.0	0.7	0.6	-1.0	0.8
Diastolic blood pressure, automated reading	1.2	3.6	5.7	-2.4	-1.7	-2.0	-1.9	1.6	-1.6
Ever depressed for a whole week	0.7	0.8	1.4	-1.1	-0.8	-1.2	-0.7	1.1	-0.2
Unable to work because of sickness or disability	0.8	1.1	1.4	0.9	1.2	1.2	1.2	-1.0	0.8
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.0	-0.4	-0.6	-0.4	0.2	-0.6
Myopia	0.5	0.7	1.7	1.3	0.8	0.9	0.6	-0.8	0.3
Vascular/heart problems diagnosed by doctor	4.6	12.6	18.7	3.0	3.7	4.3	3.2	-3.8	3.0
Cholesterol lowering medication	7.0	10.3	13.5	-3.2	-2.9	-3.7	-2.9	3.2	-3.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	0.6	0.4	-0.6	0.1	-0.1	-0.4
Pain experienced in last month	0.2	0.4	1.2	-0.5	-0.3	-0.4	-0.7	0.4	-1.1
Supplements: Calcium	0.4	0.4	1.5	-0.4	-0.1	-0.8	-0.4	0.2	-1.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.5	0.1	-0.2	0.2	-0.5	0.3
Heart attack/myocardial infarction (self-reported)	2.2	2.8	5.3	-1.6	-1.6	-2.3	-1.4	1.6	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	0.0	0.3	0.3	-0.3	0.3	0.2
Heart disease (siblings)	2.4	3.0	6.6	0.6	1.6	1.4	1.6	-1.9	2.6
Alcohol drinker status: Previous	2.4	2.7	3.8	-1.5	-1.5	-1.7	-1.6	1.5	-2.0
Pack years of smoking	0.4	0.6	1.6	-0.3	-0.1	-0.7	0.6	1.1	-1.3
Impedance of whole body	0.0	0.2	0.6	0.8	0.3	-0.3	0.1	-0.1	-0.5
Leg fat mass (left)	0.0	0.1	0.3	-0.2	0.1	0.5	0.4	-0.1	0.2
Arm predicted mass (left)	0.3	1.7	3.8	-2.0	-1.5	-1.3	-1.4	0.9	0.0