Hub : Genes

SLK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.1340 0.0590 5.8e-03 0.021 NA 0.023 NA 0.008 3.9e-02 NA 3.3e-02 NA 1.3e-01
2 ROSMAP Brain Pre-frontal Cortex 0.0587 0.0203 1.0e-04 0.045 0.044 0.046 0.056 0.052 1.8e-06 2.2e-06 1.5e-06 1.0e-07 2.9e-07
3 YFS Blood 0.0517 0.0140 2.9e-15 0.052 0.050 0.055 0.051 0.054 1.4e-16 6.6e-16 2.5e-17 2.5e-16 2.8e-17
4 TCGA Pheochromocytoma and Paraganglioma 0.0710 0.0390 4.2e-03 0.125 0.059 0.078 NA 0.074 1.1e-05 2.3e-03 5.1e-04 NA 7.0e-04
5 TCGA Thyroid Carcinoma 0.0270 0.0160 3.7e-03 0.002 0.015 0.011 NA 0.003 1.8e-01 1.3e-02 2.6e-02 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.9 2.9 -0.6 1.7 -0.5 -0.6 -0.7
Bipolar Disorder or Schizophrenia 0.8 2.0 4.2 0.2 1.2 -1.5 -2.0 -1.5
Depressed Affect (Nagel 2018) 0.4 0.8 2.8 1.7 -0.1 -0.9 -0.3 -0.7
Depression (Nagel 2018) 0.7 1.1 2.2 1.5 -0.8 -0.7 -1.3 -0.8
Intelligence (Savage-Jansen 2018) 0.7 2.3 6.0 -1.3 -1.4 2.5 0.5 1.2
Neuroticism (Nagel 2018) 0.8 1.9 5.2 2.3 -1.8 1.0 0.1 0.3
Schizophrenia (2018) 0.9 1.9 4.7 0.7 0.2 -1.5 -2.2 -1.4
Schizophrenia vs Biploar Disorder 1.2 1.6 3.8 1.9 -1.6 -0.1 -1.4 -0.3
Worry (Nagel 2018) 1.1 2.3 3.4 1.8 -1.8 1.2 1.3 1.3
Alzheimer’s Disease (in mother) 0.5 0.5 1.4 -0.3 -0.6 0.6 0.6 1.2
Alzheimer’s Disease (in father) 1.4 1.6 5.2 -0.1 2.3 -1.2 -0.4 -1.0
Alzheimer’s Disease (including proxy) 0.2 0.3 1.2 -0.5 1.1 -0.6 -0.0 -0.1
Crohns Disease (2017) 0.2 0.5 0.8 -0.8 0.9 -0.7 -0.3 -0.8
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 -0.4 0.8 -0.3 0.5 0.1
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.5 0.1 -0.0 0.7 0.6
Major Depression (MDD) 0.3 0.4 1.1 -0.7 -0.0 1.0 -0.5 0.1
Reaction Time 1.6 3.1 4.8 0.8 -1.6 2.1 1.8 2.2
Verbal and Numeric Reasoning (VNR) 1.0 2.5 6.3 -1.0 -0.9 2.5 1.2 1.7
Breast Cancer 0.8 1.9 8.2 2.9 0.5 -0.9 -0.2 -0.1
Ovarian Cancer 1.3 1.7 3.3 -0.1 0.6 1.5 1.8 1.7
Prostate Cancer 1.5 2.1 3.8 -1.9 -1.1 2.0 0.9 1.1
Age at First Birth 0.2 0.2 0.8 -0.3 -0.4 -0.3 -0.9 0.0
Bipolar Disorder (2011) 1.1 1.1 3.5 -1.3 1.9 0.1 0.3 0.5
Body Mass Index (BMI) (2010) 0.4 0.6 1.2 -0.3 -1.0 1.1 0.3 0.7
Coronary Artery Disease (CAD) 1.3 1.5 3.1 1.1 0.8 0.2 1.6 1.8
Crohns Disease (2012) 0.5 0.8 1.3 -0.7 -0.6 -0.8 -1.2 -1.0
Mean Putamen Volume 1.4 1.6 3.8 0.2 -0.1 1.1 1.9 1.8
Fasting Glucose 0.4 0.5 1.5 0.9 1.2 -0.3 0.2 -0.2
HbA1C 0.8 0.9 2.1 0.5 1.3 -1.5 -0.1 -0.8
HDL Cholesterol 1.6 2.7 5.4 1.4 1.7 -2.3 -0.6 -1.5
LDL Cholesterol 0.9 1.4 2.2 -1.4 0.8 -1.5 -0.5 -1.4
Lupus 0.5 0.8 2.3 1.5 -0.9 0.9 0.1 -0.2
Neuroticism (2016) 0.6 0.9 3.3 1.8 -0.4 1.0 -0.3 0.1
Primary Biliary Cirrhosis 1.2 1.7 4.9 -1.0 -1.3 -0.3 -2.2 -1.0
Rheumatoid Arthritis 0.7 1.0 1.9 -0.3 -1.0 1.4 0.8 1.2
Schizophrenia (2014) 1.2 2.6 7.0 -0.1 1.1 -1.3 -2.6 -1.7
Triglycerides 0.2 0.3 0.7 -0.6 -0.7 0.8 -0.1 0.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.5 -1.6 0.3 -0.1 -0.5 -0.1
Ulcerative Colitis 0.1 0.1 0.2 -0.4 0.1 0.3 0.2 0.5
Blood Eosinophil Count 0.4 3.4 6.9 1.6 2.6 -2.6 0.1 -0.9
Blood Platelet Count 0.1 1.6 4.7 -2.2 -1.2 -0.1 -1.1 -0.9
Blood Red Count 0.6 5.4 10.0 -3.2 1.0 -1.7 -2.1 -2.9
Blood White Count 0.6 4.2 6.7 2.5 2.6 -2.6 -0.1 -1.2
Heel T-Score 1.3 10.4 16.1 -3.3 -0.2 3.4 3.7 4.0
BMI 0.7 4.2 13.5 0.2 3.7 -2.5 0.1 -1.1
Height 0.8 15.5 61.8 1.3 -7.9 3.5 -1.5 0.1
Waist Hip Ratio (WHR) 0.5 2.4 6.2 2.5 -1.2 0.5 -1.5 -1.4
Systolic Blood Pressure 0.2 0.9 2.5 -1.0 -1.6 0.4 0.9 0.6
Smoking Status 1.8 4.3 9.4 1.6 3.1 -2.5 -1.1 -1.6
Allergy or Eczema 0.8 2.2 7.1 -2.7 1.2 -0.5 -0.8 -1.3
Cardiovascular Disease 0.1 0.4 0.7 -0.5 -0.3 0.7 0.8 0.7
Hypothyroidism (self reported) 0.3 0.6 2.6 0.0 0.7 -1.6 -0.1 -0.2
Respiratory disease 1.8 3.9 5.4 -1.5 2.0 -1.9 -2.1 -2.3
Type 2 Diabetes (T2D) (2018) 2.0 3.8 7.3 1.1 0.4 -1.9 -2.7 -2.5
Lung FEV1/FVC ratio 2.2 11.2 23.8 0.2 -1.4 3.1 4.9 4.5
Lung FVC 1.1 5.7 7.9 1.6 -2.8 2.2 2.5 2.7
Neuroticism 0.7 1.6 2.9 1.4 -0.7 0.9 1.7 1.4
Chronotype (morning person) 0.3 0.6 2.5 0.2 -1.6 -0.4 -0.7 -0.1
Hair Pigment 0.0 1.1 3.1 -0.4 1.3 -1.8 0.1 -0.7
Tanning 0.1 1.5 4.7 2.2 0.4 -1.0 -0.9 -1.0
Hand grip strength (left) 0.2 0.6 1.1 -1.1 -0.4 0.2 -0.8 -1.0
Number of treatments/medications taken 2.1 3.8 5.4 2.0 1.1 -1.9 -2.2 -2.3
Average weekly spirits intake 0.9 1.1 2.3 -0.2 1.5 -1.4 -0.5 -0.9
Sensitivity / hurt feelings 0.7 1.3 2.2 1.5 -1.0 -0.6 -1.3 -1.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.7 0.7 -1.6 -0.1 -1.4 -0.2
Hearing difficulty/problems: Yes 0.2 0.3 0.8 -0.8 0.1 -0.2 0.9 0.3
Relative age of first facial hair 1.3 2.6 5.4 -0.4 -2.3 2.3 0.8 1.2
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.4 0.0 -1.2 1.1 -0.4 0.5
Ever used hormone-replacement therapy (HRT) 1.4 1.8 4.5 -1.1 0.7 -2.1 -0.6 -1.6
Ever had hysterectomy (womb removed) 0.2 0.3 1.1 -1.0 -0.4 -0.0 0.3 0.0
Systolic blood pressure, automated reading 0.6 1.7 5.5 -2.3 0.8 -1.3 0.2 -0.6
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.6 -1.3 0.3 0.9 1.6 0.9
Angina 1.3 1.7 3.5 1.9 -0.2 1.4 0.7 1.7
Medication for hormone replacement therapy 1.0 1.1 4.5 -2.1 0.2 -0.9 0.5 0.0
Vitamin and mineral supplements 3.0 4.1 10.5 -0.4 -0.1 1.8 3.2 2.6
Supplements: Zinc 1.4 1.5 3.3 1.1 0.8 -0.7 -1.8 -1.3
Medication: Co-codamol 0.6 0.7 1.8 -0.7 0.4 -0.4 -0.9 -1.3
Medication: Metformin 0.8 1.1 1.9 1.3 -0.2 -1.1 -0.9 -1.4
Diabetes (father) 0.1 0.1 0.2 0.2 0.2 -0.3 0.1 -0.4
Diabetes (mother) 0.1 0.2 0.4 0.4 0.7 -0.4 -0.3 -0.1
Severe depression (siblings) 0.7 0.8 2.9 -0.2 1.7 -0.4 0.8 0.1
Pack years adult smoking proportion 2.1 3.2 5.3 -0.4 1.6 -1.9 -2.3 -2.0
Impedance of leg (right) 0.6 2.9 8.7 -0.2 -3.0 1.8 0.7 1.5
Leg fat-free mass (left) 0.1 0.4 0.7 0.5 0.6 -0.6 -0.8 -0.8
Trunk fat percentage 0.4 1.7 5.0 0.5 2.2 -1.7 0.2 -0.4
Hand grip strength (right) 0.1 0.2 0.3 -0.4 -0.5 0.6 -0.1 -0.5
Townsend deprivation index at recruitment 1.3 1.9 3.4 -0.3 1.1 -1.3 -1.9 -1.8
Current tobacco smoking 2.1 3.5 4.2 2.1 1.6 -1.9 -1.9 -1.8
Average weekly fortified wine intake 0.7 0.9 2.6 -1.6 -0.5 1.2 0.3 0.2
Maternal smoking around birth 4.4 6.3 12.0 0.7 3.5 -3.4 -1.6 -2.2
Fed-up feelings 0.5 0.9 1.4 0.7 0.4 -1.2 -0.9 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 4.1 0.9 -1.4 -0.5 -2.0 -1.0
Relative age voice broke 0.6 0.9 3.3 0.4 -1.8 0.8 0.0 0.5
Taking other prescription medications 0.5 0.8 1.7 1.3 0.1 -0.6 -1.2 -0.7
Age when periods started (menarche) 1.3 3.2 5.1 1.8 -2.2 2.3 0.8 1.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.9 -0.8 0.5 0.2 0.9 0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 5.0 -1.8 -0.6 1.8 2.0 2.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.1 0.4 1.0 -1.0 -0.6 -0.9
Qualifications: CSEs or equivalent 1.4 1.9 5.9 0.4 2.4 -1.5 0.2 -1.1
Serious illness, injury or assault to yourself 1.2 1.4 2.4 -0.1 -0.7 1.3 1.6 1.5
High blood pressure 0.2 0.6 1.4 -0.4 0.4 -1.2 -0.3 -1.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.2 -1.8 0.6 0.0 -0.6 -0.8
Multivitamins +/- minerals 1.4 1.7 5.7 0.2 -0.5 -0.7 -2.4 -1.6
Stomach or abdominal pain in last month 4.3 5.3 8.8 2.2 0.7 -2.0 -3.0 -3.0
Supplements: Glucosamine 1.3 1.7 3.5 1.0 1.0 -1.9 -1.2 -1.3
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 4.9 -0.5 2.2 -1.6 -0.2 -1.1
Medication: Atenolol 2.6 3.2 8.1 1.4 -2.8 2.4 0.1 0.7
Medication: Levothyroxine sodium 0.4 0.7 2.4 0.0 0.9 -1.5 -0.0 -0.6
Sitting height 0.0 0.2 0.6 0.4 0.3 -0.8 -0.1 -0.4
Chronic bronchitis/emphysema (father) 2.1 2.5 5.4 -0.1 1.5 -2.3 -1.1 -1.9
High blood pressure (mother) 0.3 0.4 1.3 0.0 0.2 -0.2 1.1 0.7
Body mass index (BMI) 1.2 5.1 15.6 -0.1 4.0 -2.9 -0.1 -1.2
Impedance of leg (left) 0.6 3.0 9.2 -0.1 -3.0 1.8 0.6 1.5
Leg predicted mass (left) 0.1 0.4 0.7 0.5 0.5 -0.5 -0.9 -0.8
Trunk fat mass 0.4 1.7 4.3 0.6 2.1 -1.7 -0.3 -0.8
Waist circumference 0.6 2.1 4.8 0.5 2.2 -1.9 -0.6 -1.3
Number of incorrect matches in round 1.0 1.6 3.9 0.4 -0.7 1.2 2.0 1.5
Past tobacco smoking 0.7 1.4 3.6 -0.7 -1.9 1.3 0.6 0.7
Alcohol usually taken with meals 1.9 3.0 5.0 -0.2 -2.2 1.6 1.6 2.2
Nervous feelings 0.2 0.5 1.6 0.1 -1.3 0.4 -0.5 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.7 0.1 -0.9 -0.3 -1.3 -0.7
Hearing difficulty/problems with background noise 0.1 0.2 0.9 -1.0 0.1 0.1 -0.4 -0.1
Hair/balding pattern: Pattern 2 0.3 0.3 1.0 -0.3 -0.8 1.0 -0.1 0.2
Had menopause 0.2 0.3 0.6 -0.7 -0.4 -0.8 0.0 0.0
Had other major operations 3.1 3.7 6.4 2.4 -0.1 -1.6 -2.5 -1.9
Forced vital capacity (FVC) 1.0 4.0 9.2 1.9 -3.0 1.8 1.2 1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 3.7 -1.9 1.3 0.3 1.9 1.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.4 -0.2 0.5 0.6 0.4 0.7
Qualifications: None of the above 1.1 2.3 4.8 1.6 1.6 -2.2 -0.5 -1.2
Financial difficulties in last 2 years 0.2 0.3 0.6 0.7 -0.4 -0.5 -0.8 -0.3
Mouth/teeth dental problems 0.6 0.8 2.4 1.6 -0.2 -0.8 0.1 -1.0
Heart attack 0.6 0.7 2.2 1.5 -0.4 0.6 0.8 0.5
Allergy 0.9 2.0 3.8 1.3 -0.7 0.9 2.0 1.8
Pain all over the body in last month 0.3 0.3 0.5 0.7 0.6 -0.7 0.2 -0.2
Diabetes (self-reported) 1.1 1.7 2.9 1.5 0.1 -1.4 -1.2 -1.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.9 -2.0 0.6 0.6 0.8 0.5
Medication: Ramipril 0.7 0.9 1.8 -1.0 1.3 -1.1 0.4 -0.7
Medication: Simvastatin 0.5 0.7 3.0 0.3 1.7 -0.3 -0.1 -0.4
Fluid intelligence score 2.0 4.3 10.0 -1.6 -1.5 3.2 1.4 2.2
Illnesses of siblings 1.0 1.4 2.9 -1.7 -0.9 1.6 -0.7 0.3
Neuroticism score 0.3 0.6 1.0 1.0 -0.6 0.3 1.0 0.9
Weight 0.3 1.3 2.8 0.4 1.7 -1.5 -0.6 -1.0
Impedance of arm (right) 1.1 5.3 14.6 0.6 -3.8 2.4 1.3 2.1
Arm fat percentage (right) 1.0 3.8 10.4 0.7 3.2 -2.7 0.2 -0.8
Trunk fat-free mass 0.1 0.8 2.3 0.5 -0.3 -0.5 -1.5 -1.1
Hip circumference 0.4 1.8 6.1 -0.4 2.5 -1.4 0.9 0.1
Time employed in main current job 0.1 0.2 0.4 -0.5 -0.4 0.6 -0.2 -0.0
Alcohol intake versus 10 years previously 1.4 2.1 8.5 2.9 -0.6 -0.1 -1.2 -0.6
Father’s age at death 0.3 0.4 1.2 -1.1 -0.7 0.1 -0.5 -0.1
Worrier / anxious feelings 0.4 0.7 1.4 1.2 -0.5 0.7 0.6 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.8 1.3 -0.0 0.5 -0.3 -0.1
Falls in the last year 1.8 2.4 5.5 -0.7 -0.9 2.4 1.4 1.9
Hair/balding pattern: Pattern 3 1.5 2.2 3.8 1.6 1.3 -2.0 -0.4 -1.6
Number of live births 0.5 0.7 1.5 -1.2 0.9 0.2 1.1 0.3
Forced expiratory volume in 1-second (FEV1) 2.2 7.4 11.1 1.3 -3.3 2.6 2.9 3.0
Pulse rate 0.6 0.9 2.1 -0.5 -0.4 0.9 1.5 1.2
Happiness 0.8 1.0 4.4 2.1 0.8 -0.1 -0.3 -0.1
Noisy workplace 2.6 3.1 6.2 -0.2 1.2 -1.5 -2.4 -2.5
Qualifications: A levels/AS levels or equivalent 1.4 3.1 8.3 -0.2 -2.9 2.4 0.8 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.5 1.2 -0.7 -0.1 -0.2 -0.4
Mouth/teeth dental problems: Dentures 0.5 0.9 1.8 -1.3 0.4 0.9 0.5 1.2
Asthma 3.7 7.3 12.3 -0.8 2.2 -2.8 -3.5 -3.3
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 3.0 1.3 0.3 0.1 1.7 1.7
Medication: Cholesterol lowering 0.5 0.8 3.2 1.8 0.5 -0.0 -0.2 -0.6
Depression (self-reported) 0.7 0.8 3.8 1.9 -0.6 -0.1 -0.0 0.2
Medication: Lansoprazole 2.9 3.3 6.0 0.8 1.1 -2.0 -2.5 -2.1
Prospective memory result 0.9 1.1 2.2 1.5 0.3 -1.4 -0.6 -1.1
Lung cancer (father) 0.2 0.3 0.8 0.9 0.1 -0.4 -0.1 -0.6
Illnesses of mother 0.4 0.5 1.7 0.3 -0.5 0.5 -1.3 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.5 9.5 1.3 -2.9 3.0 3.0 3.1
Pulse wave Arterial Stiffness index 0.8 0.9 3.2 -1.8 0.8 0.5 0.3 0.6
Impedance of arm (left) 0.9 4.2 8.9 -0.2 -3.0 2.3 1.7 2.0
Arm fat mass (right) 0.6 2.6 7.1 0.6 2.7 -2.3 0.1 -0.7
Trunk predicted mass 0.1 0.8 2.1 0.5 -0.3 -0.5 -1.4 -1.1
Standing height 0.7 6.6 22.3 1.1 -4.7 2.8 -1.1 0.5
Length of working week for main job 0.2 0.2 0.7 0.9 0.3 0.1 0.6 0.1
Exposure to tobacco smoke at home 0.6 0.7 2.0 0.1 1.4 -0.4 0.9 0.7
Breastfed as a baby 0.6 0.7 1.2 -1.1 -1.1 0.9 0.3 0.4
Tense / ‘highly strung’ 1.4 2.3 4.5 1.2 -2.1 1.7 0.9 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.9 0.9 -0.4 0.6 0.8 0.6
Hair/balding pattern: Pattern 4 0.6 1.5 5.2 0.7 -0.5 -0.8 -2.3 -0.9
Birth weight of first child 0.8 1.4 6.2 2.5 0.8 0.2 0.3 0.2
Peak expiratory flow (PEF) 1.5 3.5 6.4 0.7 -1.6 1.7 2.5 2.3
Pulse wave reflection index 0.6 0.7 2.1 -1.5 0.6 1.0 0.0 0.3
Ever highly irritable/argumentative for 2 days 0.9 1.0 2.2 -0.1 -0.8 1.5 0.9 1.3
Loud music exposure frequency 0.2 0.2 0.6 -0.2 0.1 0.2 -0.6 -0.8
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 2.8 -1.7 -0.8 1.0 -1.0 -0.6
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 3.2 -1.8 -1.6 0.2 -1.1 -0.2
Blood clot in the leg (DVT) 0.3 0.4 0.9 0.4 -1.0 0.6 -0.7 0.2
Medication: Paracetamol 0.6 0.9 1.9 0.1 1.4 -0.7 1.4 0.6
Headache pain in last month 0.8 1.3 2.1 1.2 1.5 -1.4 -0.7 -0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.5 -1.2 -0.5 -0.1 -0.3 0.2
Glaucoma (self-reported) 0.6 0.7 1.3 -0.6 1.2 -0.9 -0.7 -0.6
Gout (self-reported) 0.9 1.2 2.8 -0.7 -0.7 1.7 1.0 1.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 4.2 -0.6 0.5 -2.0 -0.8 -0.8
Medication: Amlodipine 0.4 0.5 1.1 0.4 0.3 0.9 1.0 0.7
Medication: Ventolin 100micrograms inhaler 4.0 5.2 11.9 -0.1 0.1 -2.5 -3.5 -2.8
Birth weight 0.2 0.5 1.2 -1.1 -0.4 0.5 0.9 0.4
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.8 -0.4 0.7 -0.9 -0.5 -1.3
High blood pressure (siblings) 0.6 0.9 2.2 -0.6 1.0 -0.8 1.5 0.6
Forced vital capacity (FVC), Best measure 1.3 4.8 9.1 1.0 -3.0 2.7 1.6 2.1
Body fat percentage 0.7 2.9 7.8 0.6 2.8 -2.3 -0.2 -0.9
Leg fat percentage (right) 1.2 4.2 10.2 -0.0 3.2 -3.0 -0.7 -1.3
Arm fat-free mass (right) 0.2 1.1 2.1 0.4 0.8 -0.9 -1.4 -1.3
Exposure to tobacco smoke outside home 0.7 0.9 1.2 0.9 1.0 -1.1 -1.0 -0.7
Comparative body size at age 10 0.3 0.8 3.5 -0.5 1.9 -0.5 0.1 0.3
Number of full brothers 0.6 0.7 1.6 0.0 1.2 0.6 1.3 0.4
Worry too long after embarrassment 3.1 5.3 8.5 0.3 -1.6 2.7 2.8 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 2.0 0.9 -1.3 1.4 -0.2 0.4
Wheeze or whistling in the chest in last year 4.0 7.1 10.4 1.3 2.0 -3.0 -3.2 -3.2
Number of children fathered 1.0 1.1 2.1 -0.9 1.4 -0.3 1.4 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.5 0.0 -0.7 0.2 0.5 -0.0
Age at first live birth 0.3 0.6 1.7 0.3 -0.7 0.6 1.3 0.7
Pulse wave peak to peak time 1.0 1.2 3.5 1.9 -1.4 -0.3 -0.5 -0.6
Health satisfaction 0.7 0.9 1.6 1.0 0.1 1.3 0.9 0.9
Shortness of breath walking on level ground 1.5 1.8 6.4 2.5 1.2 -1.0 -0.1 -0.5
Qualifications: College or University degree 1.9 5.9 12.3 0.5 -3.5 3.2 1.7 2.0
Eye problems/disorders: None of the above 0.5 0.5 1.1 1.0 -0.2 -0.9 -0.4 -0.7
Mouth/teeth dental problems: Loose teeth 3.3 4.0 7.7 1.0 0.7 -1.8 -2.7 -2.8
Emphysema/chronic bronchitis 2.3 2.6 5.1 1.5 -0.0 -2.2 -1.4 -1.9
Medication for pain relief, constipation, heartburn 1.0 1.8 3.0 -1.7 0.4 -0.4 -1.6 -1.7
Neck or shoulder pain in last month 0.7 1.1 2.8 1.2 0.5 -1.7 -0.5 -0.8
Medication: Blood pressure 0.1 0.2 0.5 0.6 0.1 0.7 0.6 0.1
Angina (self-reported) 1.4 1.8 4.1 2.0 -0.1 1.3 0.8 1.6
Migraine (self-reported) 1.3 1.6 3.2 -0.9 0.5 1.5 1.2 1.8
Medication: Ibuprofen 1.4 1.7 3.8 0.9 0.5 0.7 1.9 1.8
Medication: Allopurinol 1.8 2.3 4.9 0.4 -0.9 2.2 1.7 1.7
Medication: Omeprazole 0.6 0.7 1.8 0.6 0.6 -0.1 1.3 0.9
Medication: Seretide 50 evohaler 0.6 0.7 2.1 1.5 -0.4 -0.1 -0.9 -0.6
Mean time to correctly identify matches 0.6 1.2 2.7 0.7 -1.6 1.4 0.4 1.0
Heart disease (mother) 0.6 0.7 1.6 0.4 -0.7 0.6 1.0 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.8 0.0 0.7 -0.7 -0.5 -0.9
Whole body fat mass 0.6 2.4 5.3 0.9 2.3 -2.2 -0.5 -1.0
Leg fat mass (right) 0.8 2.9 6.6 0.3 2.6 -2.4 -0.9 -1.2
Arm predicted mass (right) 0.2 1.0 1.7 0.4 0.9 -1.0 -1.3 -1.2
Pulse rate, automated reading 0.1 0.3 0.9 0.2 1.0 -0.7 0.1 -0.1
Alcohol intake frequency. 0.6 1.3 3.3 1.4 -0.5 1.1 0.2 1.8
Comparative height size at age 10 0.3 1.7 5.6 1.1 -2.4 1.0 -0.8 0.0
Number of full sisters 0.2 0.2 0.7 0.2 0.5 -0.2 0.9 0.4
Suffer from ‘nerves’ 2.1 3.2 6.4 0.6 -1.9 2.5 1.6 1.8
Overall health rating 0.3 0.7 1.1 1.0 0.0 -0.7 -1.1 -0.9
Chest pain or discomfort 0.3 0.5 1.5 -0.4 1.2 -0.7 -0.5 -0.3
Had major operations 1.0 1.2 2.5 0.0 -0.6 1.4 1.6 1.1
Age at last live birth 0.3 0.4 1.0 -0.5 -0.5 0.7 1.0 0.3
Family relationship satisfaction 0.9 1.1 2.7 1.7 -0.8 0.7 1.0 0.8
Leg pain on walking 0.8 1.0 2.3 -1.1 -0.1 1.5 0.8 0.9
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.9 6.5 0.1 1.8 -2.1 -2.5 -2.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.4 -1.2 1.0 0.5 0.8 0.8
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 -1.4 1.1 0.7 0.3 0.2
Medication: Aspirin 0.8 1.1 4.2 2.1 -1.0 0.2 0.0 0.4
Supplements: Vitamin C 1.1 1.3 1.9 1.4 0.3 -1.2 -1.4 -1.0
Knee pain experienced in last month 0.6 0.9 2.6 -0.9 1.6 -0.9 0.2 -0.6
Hypertension (Self-reported) 0.2 0.6 1.3 -0.4 0.3 -1.1 -0.5 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.7 1.6 -1.3 -0.9 -1.2 -1.0
Illnesses of father: Heart disease 1.9 2.7 5.4 -0.3 -1.1 1.6 2.1 2.3
Illnesses of siblings: Diabetes 0.1 0.1 0.3 0.5 -0.2 0.1 -0.4 -0.3
Smoking status: Previous 0.3 0.4 1.1 -0.4 1.0 -0.7 -0.5 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.9 3.8 8.6 -0.3 -2.9 2.6 1.0 1.6
Whole body fat-free mass 0.1 0.7 1.8 0.5 0.2 -0.6 -1.3 -1.1
Leg fat-free mass (right) 0.1 0.4 0.7 0.6 0.4 -0.3 -0.9 -0.7
Arm fat percentage (left) 1.0 4.0 12.5 0.3 3.5 -2.6 0.5 -0.7
Average weekly red wine intake 1.3 2.0 4.0 -0.8 -0.6 2.0 1.8 1.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.8 -0.4 0.9 -0.0 -0.3 0.4
Mood swings 0.3 0.6 1.6 1.3 -0.6 0.4 0.6 0.7
Loneliness, isolation 0.5 0.6 2.2 1.5 -0.1 -0.8 -0.3 -0.6
Long-standing illness, disability or infirmity 0.9 1.4 2.1 1.3 0.9 -1.1 -1.4 -1.2
Ever had bowel cancer screening 1.5 1.7 2.1 1.4 1.4 -1.5 -0.8 -1.3
Diabetes diagnosed by doctor 1.2 2.0 3.5 1.9 0.0 -1.4 -1.3 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.2 3.4 1.6 1.9 -1.7 -1.1 -0.8
Friendships satisfaction 1.0 1.2 2.3 0.8 0.3 1.2 1.3 1.5
Qualifications: nursing, teaching 0.4 0.6 0.9 -1.0 -0.9 0.7 -0.7 -0.5
Commuting to job workplace: Walk 0.3 0.3 1.0 0.2 -0.5 1.0 0.1 0.4
Eye problems/disorders: Cataract 0.6 0.7 1.2 -1.1 0.9 -0.3 1.0 0.7
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 4.1 0.1 2.0 -0.1 0.2 0.2
Medication for cholesterol 0.6 1.0 1.7 1.3 0.5 0.8 0.9 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.3 -0.5 -0.1 1.1 -0.2 0.2
Back pain experienced in last month 1.6 2.4 6.1 0.1 0.1 -1.9 -2.5 -1.5
Mineral and other dietary supplements 4.0 5.4 8.0 -2.7 -0.9 2.8 2.3 2.4
Breast cancer (self-reported) 1.2 1.4 2.2 1.4 -1.5 1.4 -0.8 0.1
Asthma (self-reported) 3.6 7.2 12.7 -0.9 2.1 -2.8 -3.6 -3.3
Osteoporosis (self-reported) 0.4 0.5 1.1 0.8 -0.3 0.1 1.1 0.8
Osteoarthritis (self-reported) 0.2 0.3 0.9 -0.1 0.9 -0.6 -0.2 0.0
Medication: Aspirin 0.8 1.0 4.2 2.1 -0.7 -0.2 -0.2 0.1
Medication: Gliclazide 2.7 3.1 11.8 3.4 -1.8 -0.3 -0.4 -0.4
Illnesses of father: None of the above (group 1) 1.4 1.7 3.5 1.1 -1.9 0.2 -1.7 -0.9
Smoking status: Current 1.9 3.0 3.4 1.8 1.8 -1.8 -1.5 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.5 7.3 15.4 2.1 -3.9 2.6 2.0 2.4
Whole body water mass 0.1 0.6 1.5 0.5 0.3 -0.6 -1.2 -1.0
Leg predicted mass (right) 0.1 0.3 0.6 0.6 0.4 -0.3 -0.8 -0.7
Arm fat mass (left) 0.6 2.6 7.7 0.4 2.8 -2.1 0.2 -0.7
Number of self-reported non-cancer illnesses 2.2 3.8 8.1 0.3 0.9 -1.9 -2.9 -2.5
Average weekly champagne plus white wine intake 1.0 1.3 4.0 0.7 -2.0 1.1 0.0 1.0
Miserableness 0.9 1.5 3.1 -0.0 0.3 -1.4 -1.8 -1.6
Guilty feelings 0.2 0.3 0.4 -0.1 -0.5 0.6 0.6 0.6
Wears glasses or contact lenses 4.7 5.4 10.0 0.0 2.2 -3.2 -2.2 -2.7
Ever taken oral contraceptive pill 0.8 0.9 1.3 0.6 0.9 -1.1 -0.8 -1.1
Hearing aid user 0.4 0.5 0.9 0.7 1.0 -0.7 -0.2 -0.6
Mother’s age at death 0.4 0.4 0.6 -0.8 0.4 -0.7 -0.6 -0.8
Financial situation satisfaction 0.9 1.1 2.5 0.5 -1.6 1.0 -1.3 0.1
Tinnitus: Yes, now most or all of the time 2.4 2.8 8.0 -0.1 -1.6 2.8 0.8 1.6
Commuting to job workplace: Public transport 1.8 2.1 4.0 0.8 -2.0 -0.4 -1.5 -1.9
Eye problems/disorders: Glaucoma 0.7 0.8 1.5 0.1 0.7 -0.7 -1.2 -1.2
Medication: Blood pressure 0.2 0.5 0.9 -0.9 -0.0 -0.9 -0.2 -0.8
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.3 0.2 0.1 -0.6 -1.2 -0.5
Supplements: Fish oil (including cod liver oil) 2.7 3.5 6.0 1.9 0.8 -2.4 -1.9 -1.9
High cholesterol (Self-reported) 0.1 0.2 0.7 -0.5 0.2 0.1 -0.8 -0.5
Medication: Bendroflumethiazide 1.0 1.6 2.4 -1.6 -0.2 -0.8 -1.6 -1.6
Medication: Paracetamol 0.6 0.9 1.8 0.1 1.4 -0.7 1.3 0.6
Medication: Lisinopril 0.2 0.3 1.0 -1.0 -0.2 0.2 0.5 0.3
Medication: Atorvastatin 0.8 1.0 3.2 0.9 -1.8 1.1 -0.3 0.0
Illnesses of father: High blood pressure 0.4 0.5 1.8 -1.4 0.2 0.5 0.6 0.4
Alcohol drinker status: Never 1.3 1.6 3.9 0.8 -0.5 1.1 1.5 2.0
Ever smoked 1.0 1.8 3.8 2.0 1.6 -1.5 -0.2 -0.4
Basal metabolic rate 0.1 0.5 1.0 0.5 0.5 -0.7 -1.0 -0.9
Leg fat percentage (left) 1.2 4.3 10.8 -0.0 3.3 -2.9 -0.7 -1.3
Arm fat-free mass (left) 0.2 0.8 1.1 0.8 0.8 -1.0 -1.0 -1.0
Number of operations (self-reported) 0.2 0.2 0.3 0.5 -0.3 0.5 0.5 0.5
Average weekly beer plus cider intake 0.9 1.3 2.5 -0.3 1.3 -1.2 -1.0 -1.6
Irritability 0.5 0.9 2.5 1.6 -0.4 1.0 0.4 0.8
Risk taking 1.4 2.0 4.0 -2.0 1.4 0.6 1.6 1.0
Ever had prostate specific antigen (PSA) test 0.9 1.1 4.0 -2.0 -0.2 0.7 -0.9 0.3
Fractured/broken bones in last 5 years 1.5 1.9 3.1 1.2 -1.5 1.1 1.3 1.8
Age started oral contraceptive pill 0.4 0.5 1.7 -1.3 0.3 0.3 0.7 0.4
Diastolic blood pressure, automated reading 0.9 2.8 7.0 -2.6 1.5 0.2 2.0 0.9
Ever depressed for a whole week 0.4 0.4 1.7 1.3 0.2 0.3 0.4 0.5
Unable to work because of sickness or disability 0.9 1.1 4.5 -0.1 -0.4 0.2 -2.1 -1.0
Commuting to job workplace: Cycle 0.6 0.7 1.4 -1.2 -0.8 1.0 0.3 0.6
Myopia 0.8 1.2 2.7 -0.4 -0.1 1.2 1.2 1.6
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.3 -0.0 0.1 0.3 0.2 0.5
Cholesterol lowering medication 0.2 0.2 0.6 -0.3 -0.8 0.4 -0.3 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.0 1.0 -0.1 -0.2 0.6 0.3
Pain experienced in last month 0.8 1.3 2.4 -0.8 -0.4 1.6 1.2 1.4
Supplements: Calcium 0.3 0.4 0.7 0.8 -0.8 0.6 -0.0 0.4
Basal cell carcinoma (self-reported) 0.5 0.6 1.7 -0.4 -1.3 0.8 0.0 0.6
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.9 1.4 -0.5 0.6 0.7 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.4 0.5 -0.6 0.5 -0.5 0.2
Heart disease (siblings) 1.7 2.0 8.5 2.9 0.4 -0.8 0.9 0.1
Alcohol drinker status: Previous 1.2 1.4 3.0 -0.7 -0.1 1.6 0.9 1.7
Pack years of smoking 1.8 2.7 4.1 -0.6 1.7 -1.7 -2.0 -1.8
Impedance of whole body 0.9 4.4 11.4 0.2 -3.4 2.3 1.2 1.9
Leg fat mass (left) 0.7 2.7 6.9 0.2 2.6 -2.2 -0.7 -1.1
Arm predicted mass (left) 0.2 0.8 1.1 0.7 0.7 -0.9 -1.1 -1.0