Hub : Genes

SLK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1340	0.0590	5.8e-03	0.021	NA	0.023	NA	0.008	3.9e-02	NA	3.3e-02	NA	1.3e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.0587	0.0203	1.0e-04	0.045	0.044	0.046	0.056	0.052	1.8e-06	2.2e-06	1.5e-06	1.0e-07	2.9e-07
3	YFS	Blood	0.0517	0.0140	2.9e-15	0.052	0.050	0.055	0.051	0.054	1.4e-16	6.6e-16	2.5e-17	2.5e-16	2.8e-17
4	TCGA	Pheochromocytoma and Paraganglioma	0.0710	0.0390	4.2e-03	0.125	0.059	0.078	NA	0.074	1.1e-05	2.3e-03	5.1e-04	NA	7.0e-04
5	TCGA	Thyroid Carcinoma	0.0270	0.0160	3.7e-03	0.002	0.015	0.011	NA	0.003	1.8e-01	1.3e-02	2.6e-02	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.9	2.9	-0.6	1.7	-0.5	-0.6	-0.7
Bipolar Disorder or Schizophrenia	0.8	2.0	4.2	0.2	1.2	-1.5	-2.0	-1.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.8	1.7	-0.1	-0.9	-0.3	-0.7
Depression (Nagel 2018)	0.7	1.1	2.2	1.5	-0.8	-0.7	-1.3	-0.8
Intelligence (Savage-Jansen 2018)	0.7	2.3	6.0	-1.3	-1.4	2.5	0.5	1.2
Neuroticism (Nagel 2018)	0.8	1.9	5.2	2.3	-1.8	1.0	0.1	0.3
Schizophrenia (2018)	0.9	1.9	4.7	0.7	0.2	-1.5	-2.2	-1.4
Schizophrenia vs Biploar Disorder	1.2	1.6	3.8	1.9	-1.6	-0.1	-1.4	-0.3
Worry (Nagel 2018)	1.1	2.3	3.4	1.8	-1.8	1.2	1.3	1.3
Alzheimer’s Disease (in mother)	0.5	0.5	1.4	-0.3	-0.6	0.6	0.6	1.2
Alzheimer’s Disease (in father)	1.4	1.6	5.2	-0.1	2.3	-1.2	-0.4	-1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	-0.5	1.1	-0.6	-0.0	-0.1
Crohns Disease (2017)	0.2	0.5	0.8	-0.8	0.9	-0.7	-0.3	-0.8
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.4	0.8	-0.3	0.5	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.5	0.1	-0.0	0.7	0.6
Major Depression (MDD)	0.3	0.4	1.1	-0.7	-0.0	1.0	-0.5	0.1
Reaction Time	1.6	3.1	4.8	0.8	-1.6	2.1	1.8	2.2
Verbal and Numeric Reasoning (VNR)	1.0	2.5	6.3	-1.0	-0.9	2.5	1.2	1.7
Breast Cancer	0.8	1.9	8.2	2.9	0.5	-0.9	-0.2	-0.1
Ovarian Cancer	1.3	1.7	3.3	-0.1	0.6	1.5	1.8	1.7
Prostate Cancer	1.5	2.1	3.8	-1.9	-1.1	2.0	0.9	1.1
Age at First Birth	0.2	0.2	0.8	-0.3	-0.4	-0.3	-0.9	0.0
Bipolar Disorder (2011)	1.1	1.1	3.5	-1.3	1.9	0.1	0.3	0.5
Body Mass Index (BMI) (2010)	0.4	0.6	1.2	-0.3	-1.0	1.1	0.3	0.7
Coronary Artery Disease (CAD)	1.3	1.5	3.1	1.1	0.8	0.2	1.6	1.8
Crohns Disease (2012)	0.5	0.8	1.3	-0.7	-0.6	-0.8	-1.2	-1.0
Mean Putamen Volume	1.4	1.6	3.8	0.2	-0.1	1.1	1.9	1.8
Fasting Glucose	0.4	0.5	1.5	0.9	1.2	-0.3	0.2	-0.2
HbA1C	0.8	0.9	2.1	0.5	1.3	-1.5	-0.1	-0.8
HDL Cholesterol	1.6	2.7	5.4	1.4	1.7	-2.3	-0.6	-1.5
LDL Cholesterol	0.9	1.4	2.2	-1.4	0.8	-1.5	-0.5	-1.4
Lupus	0.5	0.8	2.3	1.5	-0.9	0.9	0.1	-0.2
Neuroticism (2016)	0.6	0.9	3.3	1.8	-0.4	1.0	-0.3	0.1
Primary Biliary Cirrhosis	1.2	1.7	4.9	-1.0	-1.3	-0.3	-2.2	-1.0
Rheumatoid Arthritis	0.7	1.0	1.9	-0.3	-1.0	1.4	0.8	1.2
Schizophrenia (2014)	1.2	2.6	7.0	-0.1	1.1	-1.3	-2.6	-1.7
Triglycerides	0.2	0.3	0.7	-0.6	-0.7	0.8	-0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.5	-1.6	0.3	-0.1	-0.5	-0.1
Ulcerative Colitis	0.1	0.1	0.2	-0.4	0.1	0.3	0.2	0.5
Blood Eosinophil Count	0.4	3.4	6.9	1.6	2.6	-2.6	0.1	-0.9
Blood Platelet Count	0.1	1.6	4.7	-2.2	-1.2	-0.1	-1.1	-0.9
Blood Red Count	0.6	5.4	10.0	-3.2	1.0	-1.7	-2.1	-2.9
Blood White Count	0.6	4.2	6.7	2.5	2.6	-2.6	-0.1	-1.2
Heel T-Score	1.3	10.4	16.1	-3.3	-0.2	3.4	3.7	4.0
BMI	0.7	4.2	13.5	0.2	3.7	-2.5	0.1	-1.1
Height	0.8	15.5	61.8	1.3	-7.9	3.5	-1.5	0.1
Waist Hip Ratio (WHR)	0.5	2.4	6.2	2.5	-1.2	0.5	-1.5	-1.4
Systolic Blood Pressure	0.2	0.9	2.5	-1.0	-1.6	0.4	0.9	0.6
Smoking Status	1.8	4.3	9.4	1.6	3.1	-2.5	-1.1	-1.6
Allergy or Eczema	0.8	2.2	7.1	-2.7	1.2	-0.5	-0.8	-1.3
Cardiovascular Disease	0.1	0.4	0.7	-0.5	-0.3	0.7	0.8	0.7
Hypothyroidism (self reported)	0.3	0.6	2.6	0.0	0.7	-1.6	-0.1	-0.2
Respiratory disease	1.8	3.9	5.4	-1.5	2.0	-1.9	-2.1	-2.3
Type 2 Diabetes (T2D) (2018)	2.0	3.8	7.3	1.1	0.4	-1.9	-2.7	-2.5
Lung FEV1/FVC ratio	2.2	11.2	23.8	0.2	-1.4	3.1	4.9	4.5
Lung FVC	1.1	5.7	7.9	1.6	-2.8	2.2	2.5	2.7
Neuroticism	0.7	1.6	2.9	1.4	-0.7	0.9	1.7	1.4
Chronotype (morning person)	0.3	0.6	2.5	0.2	-1.6	-0.4	-0.7	-0.1
Hair Pigment	0.0	1.1	3.1	-0.4	1.3	-1.8	0.1	-0.7
Tanning	0.1	1.5	4.7	2.2	0.4	-1.0	-0.9	-1.0
Hand grip strength (left)	0.2	0.6	1.1	-1.1	-0.4	0.2	-0.8	-1.0
Number of treatments/medications taken	2.1	3.8	5.4	2.0	1.1	-1.9	-2.2	-2.3
Average weekly spirits intake	0.9	1.1	2.3	-0.2	1.5	-1.4	-0.5	-0.9
Sensitivity / hurt feelings	0.7	1.3	2.2	1.5	-1.0	-0.6	-1.3	-1.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	0.7	-1.6	-0.1	-1.4	-0.2
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.8	0.1	-0.2	0.9	0.3
Relative age of first facial hair	1.3	2.6	5.4	-0.4	-2.3	2.3	0.8	1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.4	0.0	-1.2	1.1	-0.4	0.5
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.5	-1.1	0.7	-2.1	-0.6	-1.6
Ever had hysterectomy (womb removed)	0.2	0.3	1.1	-1.0	-0.4	-0.0	0.3	0.0
Systolic blood pressure, automated reading	0.6	1.7	5.5	-2.3	0.8	-1.3	0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.6	-1.3	0.3	0.9	1.6	0.9
Angina	1.3	1.7	3.5	1.9	-0.2	1.4	0.7	1.7
Medication for hormone replacement therapy	1.0	1.1	4.5	-2.1	0.2	-0.9	0.5	0.0
Vitamin and mineral supplements	3.0	4.1	10.5	-0.4	-0.1	1.8	3.2	2.6
Supplements: Zinc	1.4	1.5	3.3	1.1	0.8	-0.7	-1.8	-1.3
Medication: Co-codamol	0.6	0.7	1.8	-0.7	0.4	-0.4	-0.9	-1.3
Medication: Metformin	0.8	1.1	1.9	1.3	-0.2	-1.1	-0.9	-1.4
Diabetes (father)	0.1	0.1	0.2	0.2	0.2	-0.3	0.1	-0.4
Diabetes (mother)	0.1	0.2	0.4	0.4	0.7	-0.4	-0.3	-0.1
Severe depression (siblings)	0.7	0.8	2.9	-0.2	1.7	-0.4	0.8	0.1
Pack years adult smoking proportion	2.1	3.2	5.3	-0.4	1.6	-1.9	-2.3	-2.0
Impedance of leg (right)	0.6	2.9	8.7	-0.2	-3.0	1.8	0.7	1.5
Leg fat-free mass (left)	0.1	0.4	0.7	0.5	0.6	-0.6	-0.8	-0.8
Trunk fat percentage	0.4	1.7	5.0	0.5	2.2	-1.7	0.2	-0.4
Hand grip strength (right)	0.1	0.2	0.3	-0.4	-0.5	0.6	-0.1	-0.5
Townsend deprivation index at recruitment	1.3	1.9	3.4	-0.3	1.1	-1.3	-1.9	-1.8
Current tobacco smoking	2.1	3.5	4.2	2.1	1.6	-1.9	-1.9	-1.8
Average weekly fortified wine intake	0.7	0.9	2.6	-1.6	-0.5	1.2	0.3	0.2
Maternal smoking around birth	4.4	6.3	12.0	0.7	3.5	-3.4	-1.6	-2.2
Fed-up feelings	0.5	0.9	1.4	0.7	0.4	-1.2	-0.9	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	4.1	0.9	-1.4	-0.5	-2.0	-1.0
Relative age voice broke	0.6	0.9	3.3	0.4	-1.8	0.8	0.0	0.5
Taking other prescription medications	0.5	0.8	1.7	1.3	0.1	-0.6	-1.2	-0.7
Age when periods started (menarche)	1.3	3.2	5.1	1.8	-2.2	2.3	0.8	1.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	-0.8	0.5	0.2	0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	5.0	-1.8	-0.6	1.8	2.0	2.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.1	0.4	1.0	-1.0	-0.6	-0.9
Qualifications: CSEs or equivalent	1.4	1.9	5.9	0.4	2.4	-1.5	0.2	-1.1
Serious illness, injury or assault to yourself	1.2	1.4	2.4	-0.1	-0.7	1.3	1.6	1.5
High blood pressure	0.2	0.6	1.4	-0.4	0.4	-1.2	-0.3	-1.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.2	-1.8	0.6	0.0	-0.6	-0.8
Multivitamins +/- minerals	1.4	1.7	5.7	0.2	-0.5	-0.7	-2.4	-1.6
Stomach or abdominal pain in last month	4.3	5.3	8.8	2.2	0.7	-2.0	-3.0	-3.0
Supplements: Glucosamine	1.3	1.7	3.5	1.0	1.0	-1.9	-1.2	-1.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.9	-0.5	2.2	-1.6	-0.2	-1.1
Medication: Atenolol	2.6	3.2	8.1	1.4	-2.8	2.4	0.1	0.7
Medication: Levothyroxine sodium	0.4	0.7	2.4	0.0	0.9	-1.5	-0.0	-0.6
Sitting height	0.0	0.2	0.6	0.4	0.3	-0.8	-0.1	-0.4
Chronic bronchitis/emphysema (father)	2.1	2.5	5.4	-0.1	1.5	-2.3	-1.1	-1.9
High blood pressure (mother)	0.3	0.4	1.3	0.0	0.2	-0.2	1.1	0.7
Body mass index (BMI)	1.2	5.1	15.6	-0.1	4.0	-2.9	-0.1	-1.2
Impedance of leg (left)	0.6	3.0	9.2	-0.1	-3.0	1.8	0.6	1.5
Leg predicted mass (left)	0.1	0.4	0.7	0.5	0.5	-0.5	-0.9	-0.8
Trunk fat mass	0.4	1.7	4.3	0.6	2.1	-1.7	-0.3	-0.8
Waist circumference	0.6	2.1	4.8	0.5	2.2	-1.9	-0.6	-1.3
Number of incorrect matches in round	1.0	1.6	3.9	0.4	-0.7	1.2	2.0	1.5
Past tobacco smoking	0.7	1.4	3.6	-0.7	-1.9	1.3	0.6	0.7
Alcohol usually taken with meals	1.9	3.0	5.0	-0.2	-2.2	1.6	1.6	2.2
Nervous feelings	0.2	0.5	1.6	0.1	-1.3	0.4	-0.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.7	0.1	-0.9	-0.3	-1.3	-0.7
Hearing difficulty/problems with background noise	0.1	0.2	0.9	-1.0	0.1	0.1	-0.4	-0.1
Hair/balding pattern: Pattern 2	0.3	0.3	1.0	-0.3	-0.8	1.0	-0.1	0.2
Had menopause	0.2	0.3	0.6	-0.7	-0.4	-0.8	0.0	0.0
Had other major operations	3.1	3.7	6.4	2.4	-0.1	-1.6	-2.5	-1.9
Forced vital capacity (FVC)	1.0	4.0	9.2	1.9	-3.0	1.8	1.2	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.7	-1.9	1.3	0.3	1.9	1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	-0.2	0.5	0.6	0.4	0.7
Qualifications: None of the above	1.1	2.3	4.8	1.6	1.6	-2.2	-0.5	-1.2
Financial difficulties in last 2 years	0.2	0.3	0.6	0.7	-0.4	-0.5	-0.8	-0.3
Mouth/teeth dental problems	0.6	0.8	2.4	1.6	-0.2	-0.8	0.1	-1.0
Heart attack	0.6	0.7	2.2	1.5	-0.4	0.6	0.8	0.5
Allergy	0.9	2.0	3.8	1.3	-0.7	0.9	2.0	1.8
Pain all over the body in last month	0.3	0.3	0.5	0.7	0.6	-0.7	0.2	-0.2
Diabetes (self-reported)	1.1	1.7	2.9	1.5	0.1	-1.4	-1.2	-1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.9	-2.0	0.6	0.6	0.8	0.5
Medication: Ramipril	0.7	0.9	1.8	-1.0	1.3	-1.1	0.4	-0.7
Medication: Simvastatin	0.5	0.7	3.0	0.3	1.7	-0.3	-0.1	-0.4
Fluid intelligence score	2.0	4.3	10.0	-1.6	-1.5	3.2	1.4	2.2
Illnesses of siblings	1.0	1.4	2.9	-1.7	-0.9	1.6	-0.7	0.3
Neuroticism score	0.3	0.6	1.0	1.0	-0.6	0.3	1.0	0.9
Weight	0.3	1.3	2.8	0.4	1.7	-1.5	-0.6	-1.0
Impedance of arm (right)	1.1	5.3	14.6	0.6	-3.8	2.4	1.3	2.1
Arm fat percentage (right)	1.0	3.8	10.4	0.7	3.2	-2.7	0.2	-0.8
Trunk fat-free mass	0.1	0.8	2.3	0.5	-0.3	-0.5	-1.5	-1.1
Hip circumference	0.4	1.8	6.1	-0.4	2.5	-1.4	0.9	0.1
Time employed in main current job	0.1	0.2	0.4	-0.5	-0.4	0.6	-0.2	-0.0
Alcohol intake versus 10 years previously	1.4	2.1	8.5	2.9	-0.6	-0.1	-1.2	-0.6
Father’s age at death	0.3	0.4	1.2	-1.1	-0.7	0.1	-0.5	-0.1
Worrier / anxious feelings	0.4	0.7	1.4	1.2	-0.5	0.7	0.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.8	1.3	-0.0	0.5	-0.3	-0.1
Falls in the last year	1.8	2.4	5.5	-0.7	-0.9	2.4	1.4	1.9
Hair/balding pattern: Pattern 3	1.5	2.2	3.8	1.6	1.3	-2.0	-0.4	-1.6
Number of live births	0.5	0.7	1.5	-1.2	0.9	0.2	1.1	0.3
Forced expiratory volume in 1-second (FEV1)	2.2	7.4	11.1	1.3	-3.3	2.6	2.9	3.0
Pulse rate	0.6	0.9	2.1	-0.5	-0.4	0.9	1.5	1.2
Happiness	0.8	1.0	4.4	2.1	0.8	-0.1	-0.3	-0.1
Noisy workplace	2.6	3.1	6.2	-0.2	1.2	-1.5	-2.4	-2.5
Qualifications: A levels/AS levels or equivalent	1.4	3.1	8.3	-0.2	-2.9	2.4	0.8	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.5	1.2	-0.7	-0.1	-0.2	-0.4
Mouth/teeth dental problems: Dentures	0.5	0.9	1.8	-1.3	0.4	0.9	0.5	1.2
Asthma	3.7	7.3	12.3	-0.8	2.2	-2.8	-3.5	-3.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.0	1.3	0.3	0.1	1.7	1.7
Medication: Cholesterol lowering	0.5	0.8	3.2	1.8	0.5	-0.0	-0.2	-0.6
Depression (self-reported)	0.7	0.8	3.8	1.9	-0.6	-0.1	-0.0	0.2
Medication: Lansoprazole	2.9	3.3	6.0	0.8	1.1	-2.0	-2.5	-2.1
Prospective memory result	0.9	1.1	2.2	1.5	0.3	-1.4	-0.6	-1.1
Lung cancer (father)	0.2	0.3	0.8	0.9	0.1	-0.4	-0.1	-0.6
Illnesses of mother	0.4	0.5	1.7	0.3	-0.5	0.5	-1.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.5	9.5	1.3	-2.9	3.0	3.0	3.1
Pulse wave Arterial Stiffness index	0.8	0.9	3.2	-1.8	0.8	0.5	0.3	0.6
Impedance of arm (left)	0.9	4.2	8.9	-0.2	-3.0	2.3	1.7	2.0
Arm fat mass (right)	0.6	2.6	7.1	0.6	2.7	-2.3	0.1	-0.7
Trunk predicted mass	0.1	0.8	2.1	0.5	-0.3	-0.5	-1.4	-1.1
Standing height	0.7	6.6	22.3	1.1	-4.7	2.8	-1.1	0.5
Length of working week for main job	0.2	0.2	0.7	0.9	0.3	0.1	0.6	0.1
Exposure to tobacco smoke at home	0.6	0.7	2.0	0.1	1.4	-0.4	0.9	0.7
Breastfed as a baby	0.6	0.7	1.2	-1.1	-1.1	0.9	0.3	0.4
Tense / ‘highly strung’	1.4	2.3	4.5	1.2	-2.1	1.7	0.9	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.9	-0.4	0.6	0.8	0.6
Hair/balding pattern: Pattern 4	0.6	1.5	5.2	0.7	-0.5	-0.8	-2.3	-0.9
Birth weight of first child	0.8	1.4	6.2	2.5	0.8	0.2	0.3	0.2
Peak expiratory flow (PEF)	1.5	3.5	6.4	0.7	-1.6	1.7	2.5	2.3
Pulse wave reflection index	0.6	0.7	2.1	-1.5	0.6	1.0	0.0	0.3
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.2	-0.1	-0.8	1.5	0.9	1.3
Loud music exposure frequency	0.2	0.2	0.6	-0.2	0.1	0.2	-0.6	-0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.8	-1.7	-0.8	1.0	-1.0	-0.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.2	-1.8	-1.6	0.2	-1.1	-0.2
Blood clot in the leg (DVT)	0.3	0.4	0.9	0.4	-1.0	0.6	-0.7	0.2
Medication: Paracetamol	0.6	0.9	1.9	0.1	1.4	-0.7	1.4	0.6
Headache pain in last month	0.8	1.3	2.1	1.2	1.5	-1.4	-0.7	-0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.5	-1.2	-0.5	-0.1	-0.3	0.2
Glaucoma (self-reported)	0.6	0.7	1.3	-0.6	1.2	-0.9	-0.7	-0.6
Gout (self-reported)	0.9	1.2	2.8	-0.7	-0.7	1.7	1.0	1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.2	-0.6	0.5	-2.0	-0.8	-0.8
Medication: Amlodipine	0.4	0.5	1.1	0.4	0.3	0.9	1.0	0.7
Medication: Ventolin 100micrograms inhaler	4.0	5.2	11.9	-0.1	0.1	-2.5	-3.5	-2.8
Birth weight	0.2	0.5	1.2	-1.1	-0.4	0.5	0.9	0.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	-0.4	0.7	-0.9	-0.5	-1.3
High blood pressure (siblings)	0.6	0.9	2.2	-0.6	1.0	-0.8	1.5	0.6
Forced vital capacity (FVC), Best measure	1.3	4.8	9.1	1.0	-3.0	2.7	1.6	2.1
Body fat percentage	0.7	2.9	7.8	0.6	2.8	-2.3	-0.2	-0.9
Leg fat percentage (right)	1.2	4.2	10.2	-0.0	3.2	-3.0	-0.7	-1.3
Arm fat-free mass (right)	0.2	1.1	2.1	0.4	0.8	-0.9	-1.4	-1.3
Exposure to tobacco smoke outside home	0.7	0.9	1.2	0.9	1.0	-1.1	-1.0	-0.7
Comparative body size at age 10	0.3	0.8	3.5	-0.5	1.9	-0.5	0.1	0.3
Number of full brothers	0.6	0.7	1.6	0.0	1.2	0.6	1.3	0.4
Worry too long after embarrassment	3.1	5.3	8.5	0.3	-1.6	2.7	2.8	2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.0	0.9	-1.3	1.4	-0.2	0.4
Wheeze or whistling in the chest in last year	4.0	7.1	10.4	1.3	2.0	-3.0	-3.2	-3.2
Number of children fathered	1.0	1.1	2.1	-0.9	1.4	-0.3	1.4	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	0.0	-0.7	0.2	0.5	-0.0
Age at first live birth	0.3	0.6	1.7	0.3	-0.7	0.6	1.3	0.7
Pulse wave peak to peak time	1.0	1.2	3.5	1.9	-1.4	-0.3	-0.5	-0.6
Health satisfaction	0.7	0.9	1.6	1.0	0.1	1.3	0.9	0.9
Shortness of breath walking on level ground	1.5	1.8	6.4	2.5	1.2	-1.0	-0.1	-0.5
Qualifications: College or University degree	1.9	5.9	12.3	0.5	-3.5	3.2	1.7	2.0
Eye problems/disorders: None of the above	0.5	0.5	1.1	1.0	-0.2	-0.9	-0.4	-0.7
Mouth/teeth dental problems: Loose teeth	3.3	4.0	7.7	1.0	0.7	-1.8	-2.7	-2.8
Emphysema/chronic bronchitis	2.3	2.6	5.1	1.5	-0.0	-2.2	-1.4	-1.9
Medication for pain relief, constipation, heartburn	1.0	1.8	3.0	-1.7	0.4	-0.4	-1.6	-1.7
Neck or shoulder pain in last month	0.7	1.1	2.8	1.2	0.5	-1.7	-0.5	-0.8
Medication: Blood pressure	0.1	0.2	0.5	0.6	0.1	0.7	0.6	0.1
Angina (self-reported)	1.4	1.8	4.1	2.0	-0.1	1.3	0.8	1.6
Migraine (self-reported)	1.3	1.6	3.2	-0.9	0.5	1.5	1.2	1.8
Medication: Ibuprofen	1.4	1.7	3.8	0.9	0.5	0.7	1.9	1.8
Medication: Allopurinol	1.8	2.3	4.9	0.4	-0.9	2.2	1.7	1.7
Medication: Omeprazole	0.6	0.7	1.8	0.6	0.6	-0.1	1.3	0.9
Medication: Seretide 50 evohaler	0.6	0.7	2.1	1.5	-0.4	-0.1	-0.9	-0.6
Mean time to correctly identify matches	0.6	1.2	2.7	0.7	-1.6	1.4	0.4	1.0
Heart disease (mother)	0.6	0.7	1.6	0.4	-0.7	0.6	1.0	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	0.0	0.7	-0.7	-0.5	-0.9
Whole body fat mass	0.6	2.4	5.3	0.9	2.3	-2.2	-0.5	-1.0
Leg fat mass (right)	0.8	2.9	6.6	0.3	2.6	-2.4	-0.9	-1.2
Arm predicted mass (right)	0.2	1.0	1.7	0.4	0.9	-1.0	-1.3	-1.2
Pulse rate, automated reading	0.1	0.3	0.9	0.2	1.0	-0.7	0.1	-0.1
Alcohol intake frequency.	0.6	1.3	3.3	1.4	-0.5	1.1	0.2	1.8
Comparative height size at age 10	0.3	1.7	5.6	1.1	-2.4	1.0	-0.8	0.0
Number of full sisters	0.2	0.2	0.7	0.2	0.5	-0.2	0.9	0.4
Suffer from ‘nerves’	2.1	3.2	6.4	0.6	-1.9	2.5	1.6	1.8
Overall health rating	0.3	0.7	1.1	1.0	0.0	-0.7	-1.1	-0.9
Chest pain or discomfort	0.3	0.5	1.5	-0.4	1.2	-0.7	-0.5	-0.3
Had major operations	1.0	1.2	2.5	0.0	-0.6	1.4	1.6	1.1
Age at last live birth	0.3	0.4	1.0	-0.5	-0.5	0.7	1.0	0.3
Family relationship satisfaction	0.9	1.1	2.7	1.7	-0.8	0.7	1.0	0.8
Leg pain on walking	0.8	1.0	2.3	-1.1	-0.1	1.5	0.8	0.9
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.9	6.5	0.1	1.8	-2.1	-2.5	-2.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	-1.2	1.0	0.5	0.8	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.0	-1.4	1.1	0.7	0.3	0.2
Medication: Aspirin	0.8	1.1	4.2	2.1	-1.0	0.2	0.0	0.4
Supplements: Vitamin C	1.1	1.3	1.9	1.4	0.3	-1.2	-1.4	-1.0
Knee pain experienced in last month	0.6	0.9	2.6	-0.9	1.6	-0.9	0.2	-0.6
Hypertension (Self-reported)	0.2	0.6	1.3	-0.4	0.3	-1.1	-0.5	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.7	1.6	-1.3	-0.9	-1.2	-1.0
Illnesses of father: Heart disease	1.9	2.7	5.4	-0.3	-1.1	1.6	2.1	2.3
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.5	-0.2	0.1	-0.4	-0.3
Smoking status: Previous	0.3	0.4	1.1	-0.4	1.0	-0.7	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.8	8.6	-0.3	-2.9	2.6	1.0	1.6
Whole body fat-free mass	0.1	0.7	1.8	0.5	0.2	-0.6	-1.3	-1.1
Leg fat-free mass (right)	0.1	0.4	0.7	0.6	0.4	-0.3	-0.9	-0.7
Arm fat percentage (left)	1.0	4.0	12.5	0.3	3.5	-2.6	0.5	-0.7
Average weekly red wine intake	1.3	2.0	4.0	-0.8	-0.6	2.0	1.8	1.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	-0.4	0.9	-0.0	-0.3	0.4
Mood swings	0.3	0.6	1.6	1.3	-0.6	0.4	0.6	0.7
Loneliness, isolation	0.5	0.6	2.2	1.5	-0.1	-0.8	-0.3	-0.6
Long-standing illness, disability or infirmity	0.9	1.4	2.1	1.3	0.9	-1.1	-1.4	-1.2
Ever had bowel cancer screening	1.5	1.7	2.1	1.4	1.4	-1.5	-0.8	-1.3
Diabetes diagnosed by doctor	1.2	2.0	3.5	1.9	0.0	-1.4	-1.3	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	3.4	1.6	1.9	-1.7	-1.1	-0.8
Friendships satisfaction	1.0	1.2	2.3	0.8	0.3	1.2	1.3	1.5
Qualifications: nursing, teaching	0.4	0.6	0.9	-1.0	-0.9	0.7	-0.7	-0.5
Commuting to job workplace: Walk	0.3	0.3	1.0	0.2	-0.5	1.0	0.1	0.4
Eye problems/disorders: Cataract	0.6	0.7	1.2	-1.1	0.9	-0.3	1.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	4.1	0.1	2.0	-0.1	0.2	0.2
Medication for cholesterol	0.6	1.0	1.7	1.3	0.5	0.8	0.9	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.3	-0.5	-0.1	1.1	-0.2	0.2
Back pain experienced in last month	1.6	2.4	6.1	0.1	0.1	-1.9	-2.5	-1.5
Mineral and other dietary supplements	4.0	5.4	8.0	-2.7	-0.9	2.8	2.3	2.4
Breast cancer (self-reported)	1.2	1.4	2.2	1.4	-1.5	1.4	-0.8	0.1
Asthma (self-reported)	3.6	7.2	12.7	-0.9	2.1	-2.8	-3.6	-3.3
Osteoporosis (self-reported)	0.4	0.5	1.1	0.8	-0.3	0.1	1.1	0.8
Osteoarthritis (self-reported)	0.2	0.3	0.9	-0.1	0.9	-0.6	-0.2	0.0
Medication: Aspirin	0.8	1.0	4.2	2.1	-0.7	-0.2	-0.2	0.1
Medication: Gliclazide	2.7	3.1	11.8	3.4	-1.8	-0.3	-0.4	-0.4
Illnesses of father: None of the above (group 1)	1.4	1.7	3.5	1.1	-1.9	0.2	-1.7	-0.9
Smoking status: Current	1.9	3.0	3.4	1.8	1.8	-1.8	-1.5	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.3	15.4	2.1	-3.9	2.6	2.0	2.4
Whole body water mass	0.1	0.6	1.5	0.5	0.3	-0.6	-1.2	-1.0
Leg predicted mass (right)	0.1	0.3	0.6	0.6	0.4	-0.3	-0.8	-0.7
Arm fat mass (left)	0.6	2.6	7.7	0.4	2.8	-2.1	0.2	-0.7
Number of self-reported non-cancer illnesses	2.2	3.8	8.1	0.3	0.9	-1.9	-2.9	-2.5
Average weekly champagne plus white wine intake	1.0	1.3	4.0	0.7	-2.0	1.1	0.0	1.0
Miserableness	0.9	1.5	3.1	-0.0	0.3	-1.4	-1.8	-1.6
Guilty feelings	0.2	0.3	0.4	-0.1	-0.5	0.6	0.6	0.6
Wears glasses or contact lenses	4.7	5.4	10.0	0.0	2.2	-3.2	-2.2	-2.7
Ever taken oral contraceptive pill	0.8	0.9	1.3	0.6	0.9	-1.1	-0.8	-1.1
Hearing aid user	0.4	0.5	0.9	0.7	1.0	-0.7	-0.2	-0.6
Mother’s age at death	0.4	0.4	0.6	-0.8	0.4	-0.7	-0.6	-0.8
Financial situation satisfaction	0.9	1.1	2.5	0.5	-1.6	1.0	-1.3	0.1
Tinnitus: Yes, now most or all of the time	2.4	2.8	8.0	-0.1	-1.6	2.8	0.8	1.6
Commuting to job workplace: Public transport	1.8	2.1	4.0	0.8	-2.0	-0.4	-1.5	-1.9
Eye problems/disorders: Glaucoma	0.7	0.8	1.5	0.1	0.7	-0.7	-1.2	-1.2
Medication: Blood pressure	0.2	0.5	0.9	-0.9	-0.0	-0.9	-0.2	-0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	0.2	0.1	-0.6	-1.2	-0.5
Supplements: Fish oil (including cod liver oil)	2.7	3.5	6.0	1.9	0.8	-2.4	-1.9	-1.9
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.5	0.2	0.1	-0.8	-0.5
Medication: Bendroflumethiazide	1.0	1.6	2.4	-1.6	-0.2	-0.8	-1.6	-1.6
Medication: Paracetamol	0.6	0.9	1.8	0.1	1.4	-0.7	1.3	0.6
Medication: Lisinopril	0.2	0.3	1.0	-1.0	-0.2	0.2	0.5	0.3
Medication: Atorvastatin	0.8	1.0	3.2	0.9	-1.8	1.1	-0.3	0.0
Illnesses of father: High blood pressure	0.4	0.5	1.8	-1.4	0.2	0.5	0.6	0.4
Alcohol drinker status: Never	1.3	1.6	3.9	0.8	-0.5	1.1	1.5	2.0
Ever smoked	1.0	1.8	3.8	2.0	1.6	-1.5	-0.2	-0.4
Basal metabolic rate	0.1	0.5	1.0	0.5	0.5	-0.7	-1.0	-0.9
Leg fat percentage (left)	1.2	4.3	10.8	-0.0	3.3	-2.9	-0.7	-1.3
Arm fat-free mass (left)	0.2	0.8	1.1	0.8	0.8	-1.0	-1.0	-1.0
Number of operations (self-reported)	0.2	0.2	0.3	0.5	-0.3	0.5	0.5	0.5
Average weekly beer plus cider intake	0.9	1.3	2.5	-0.3	1.3	-1.2	-1.0	-1.6
Irritability	0.5	0.9	2.5	1.6	-0.4	1.0	0.4	0.8
Risk taking	1.4	2.0	4.0	-2.0	1.4	0.6	1.6	1.0
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.0	-2.0	-0.2	0.7	-0.9	0.3
Fractured/broken bones in last 5 years	1.5	1.9	3.1	1.2	-1.5	1.1	1.3	1.8
Age started oral contraceptive pill	0.4	0.5	1.7	-1.3	0.3	0.3	0.7	0.4
Diastolic blood pressure, automated reading	0.9	2.8	7.0	-2.6	1.5	0.2	2.0	0.9
Ever depressed for a whole week	0.4	0.4	1.7	1.3	0.2	0.3	0.4	0.5
Unable to work because of sickness or disability	0.9	1.1	4.5	-0.1	-0.4	0.2	-2.1	-1.0
Commuting to job workplace: Cycle	0.6	0.7	1.4	-1.2	-0.8	1.0	0.3	0.6
Myopia	0.8	1.2	2.7	-0.4	-0.1	1.2	1.2	1.6
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	-0.0	0.1	0.3	0.2	0.5
Cholesterol lowering medication	0.2	0.2	0.6	-0.3	-0.8	0.4	-0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.0	1.0	-0.1	-0.2	0.6	0.3
Pain experienced in last month	0.8	1.3	2.4	-0.8	-0.4	1.6	1.2	1.4
Supplements: Calcium	0.3	0.4	0.7	0.8	-0.8	0.6	-0.0	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	-0.4	-1.3	0.8	0.0	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.9	1.4	-0.5	0.6	0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	0.5	-0.6	0.5	-0.5	0.2
Heart disease (siblings)	1.7	2.0	8.5	2.9	0.4	-0.8	0.9	0.1
Alcohol drinker status: Previous	1.2	1.4	3.0	-0.7	-0.1	1.6	0.9	1.7
Pack years of smoking	1.8	2.7	4.1	-0.6	1.7	-1.7	-2.0	-1.8
Impedance of whole body	0.9	4.4	11.4	0.2	-3.4	2.3	1.2	1.9
Leg fat mass (left)	0.7	2.7	6.9	0.2	2.6	-2.2	-0.7	-1.1
Arm predicted mass (left)	0.2	0.8	1.1	0.7	0.7	-0.9	-1.1	-1.0