Hub : Genes

SMAD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.3390	0.1050	0.00360	-0.004	NA	0.073	NA	0.068	4.0e-01	NA	8.3e-03	NA	1.1e-02
2	GTEx	Cells Transformed fibroblasts	0.2880	0.0760	0.00001	0.168	NA	0.161	NA	0.134	1.2e-12	NA	3.8e-12	NA	3.2e-10
3	TCGA	Brain Lower Grade Glioma	0.0280	0.0189	0.00430	0.017	0.004	0.004	NA	0.008	4.1e-03	0.1000	1.0e-01	NA	3.8e-02
4	TCGA	Prostate Adenocarcinoma	0.0433	0.0254	0.00420	0.008	0.021	0.013	NA	0.012	4.8e-02	0.0023	1.3e-02	NA	1.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.0	0.1	0.1	0.3	-0.1	-0.3	0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	2.0	-0.5	-0.6	0.4	1.4
Depressed Affect (Nagel 2018)	0.7	1.4	3.1	-0.8	-1.2	-1.8	-0.4
Depression (Nagel 2018)	0.5	0.7	2.4	-0.4	-0.3	-1.6	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.3	-0.5	-0.6	1.1	-0.7
Neuroticism (Nagel 2018)	0.3	0.6	1.4	-0.8	-0.5	-1.2	-0.4
Schizophrenia (2018)	0.6	1.2	2.8	-0.9	-0.7	0.7	1.7
Schizophrenia vs Biploar Disorder	0.9	1.2	2.3	0.5	-0.7	1.5	1.2
Worry (Nagel 2018)	0.1	0.2	0.5	0.1	-0.5	0.1	0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.4	0.7	-0.2	-0.3
Alzheimer’s Disease (in father)	0.6	0.6	1.8	1.4	-0.3	0.0	-0.7
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	0.9	0.6	-0.5	-1.0
Crohns Disease (2017)	0.7	1.6	3.2	-1.1	0.3	-1.8	-1.3
Irritable Bowel Disease (IBD)	1.3	3.0	3.8	-1.9	1.4	-2.0	-1.6
Ulcerative Colitis (UC)	1.4	2.6	4.2	-2.0	1.6	-1.5	-1.3
Major Depression (MDD)	0.7	0.9	2.0	0.4	0.1	-1.4	-1.2
Reaction Time	1.1	2.0	5.7	-0.4	2.4	-1.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.3	-0.3	-1.2	1.0	-1.8
Breast Cancer	0.4	1.0	3.1	-0.2	-1.8	0.7	0.5
Ovarian Cancer	0.2	0.3	0.8	0.3	0.2	-0.4	-0.9
Prostate Cancer	4.9	6.9	17.0	0.5	1.6	-2.8	-4.1
Age at First Birth	1.5	2.2	5.3	2.3	0.2	1.4	1.3
Bipolar Disorder (2011)	0.4	0.4	1.3	0.1	0.3	-1.1	-0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.1	0.5	-0.2	0.1
Coronary Artery Disease (CAD)	1.5	1.8	3.2	-1.8	-1.5	-0.7	-1.1
Crohns Disease (2012)	1.5	2.5	3.9	-1.4	1.1	-2.0	-1.6
Mean Putamen Volume	1.0	1.1	2.7	-1.0	0.1	1.6	1.0
Fasting Glucose	1.6	1.9	4.1	-2.0	1.6	-0.8	-0.7
HbA1C	0.7	0.8	2.9	-1.7	0.3	0.1	0.4
HDL Cholesterol	1.4	2.3	4.3	0.0	-1.0	2.0	2.1
LDL Cholesterol	0.3	0.5	2.0	-0.1	-0.3	1.4	0.1
Lupus	1.4	2.1	7.2	-2.7	-0.2	0.3	0.9
Neuroticism (2016)	0.2	0.3	0.9	-0.3	1.0	-0.2	-0.5
Primary Biliary Cirrhosis	0.8	1.1	2.9	1.1	-0.5	-0.3	-1.7
Rheumatoid Arthritis	0.5	0.7	1.1	0.1	-1.0	1.0	0.9
Schizophrenia (2014)	0.6	1.2	3.8	-0.1	-0.4	1.0	2.0
Triglycerides	0.3	0.5	1.7	-1.3	-0.3	0.3	-0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	-1.0	0.8	0.6	-0.6
Ulcerative Colitis	3.1	4.6	7.0	-2.6	2.3	-1.6	-1.8
Blood Eosinophil Count	0.5	3.6	9.5	-1.1	3.1	0.3	-1.9
Blood Platelet Count	0.1	1.4	5.4	-2.3	0.2	0.5	-0.1
Blood Red Count	0.2	1.8	2.1	-1.2	1.4	-1.4	-1.3
Blood White Count	0.3	2.6	3.8	-1.8	-0.2	1.9	1.7
Heel T-Score	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.4
BMI	0.4	2.0	7.1	-2.7	0.7	-0.7	0.3
Height	0.3	6.6	15.4	3.9	1.7	-2.0	-1.9
Waist Hip Ratio (WHR)	2.6	11.8	22.3	-0.0	-3.2	4.7	3.9
Systolic Blood Pressure	0.2	1.0	1.4	-1.1	1.1	1.2	-0.4
Smoking Status	0.3	0.6	2.4	-1.6	-0.2	0.2	0.2
Allergy or Eczema	0.6	1.6	3.1	0.6	1.7	1.7	0.2
Cardiovascular Disease	0.5	1.8	5.5	-2.4	0.8	-0.8	-0.5
Hypothyroidism (self reported)	0.3	0.6	1.4	0.7	0.0	-1.2	-0.7
Respiratory disease	0.1	0.3	0.6	-0.8	-0.2	0.6	0.2
Type 2 Diabetes (T2D) (2018)	0.8	1.5	5.7	-2.4	0.0	0.5	-0.0
Lung FEV1/FVC ratio	0.2	0.9	3.1	0.2	-0.5	-1.8	-0.2
Lung FVC	0.3	1.5	4.7	2.2	0.5	0.8	0.5
Neuroticism	0.4	0.9	1.4	-0.4	-1.2	-1.1	0.8
Chronotype (morning person)	1.5	3.4	8.1	1.0	-1.4	2.8	1.6
Hair Pigment	0.2	4.8	7.3	-1.9	-1.3	2.7	2.6
Tanning	0.1	1.1	2.6	1.2	1.6	0.8	-0.2
Hand grip strength (left)	0.2	0.6	1.3	-0.1	0.8	-0.8	-1.2
Number of treatments/medications taken	0.6	1.1	2.2	-0.4	1.0	-1.0	-1.5
Average weekly spirits intake	1.8	2.3	5.7	-2.4	-1.1	0.4	1.5
Sensitivity / hurt feelings	0.6	1.1	2.7	-0.2	0.7	-1.6	-1.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.6	-0.1	0.3	0.3
Hearing difficulty/problems: Yes	0.8	1.3	3.4	0.8	0.1	1.1	1.8
Relative age of first facial hair	0.3	0.7	1.6	1.3	-0.2	0.0	-1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	-0.6	1.0	-1.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.3	-1.8	0.0	0.6	-0.0
Ever had hysterectomy (womb removed)	1.3	1.5	4.0	-1.3	0.6	-0.2	-2.0
Systolic blood pressure, automated reading	0.9	2.5	4.2	-2.1	2.0	0.6	-1.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.8	-1.2	-0.1	-1.7	-1.2
Angina	0.8	1.0	1.5	1.1	0.8	-1.2	-0.8
Medication for hormone replacement therapy	1.5	1.7	4.2	-2.1	1.4	-0.7	-0.1
Vitamin and mineral supplements	1.8	2.4	4.2	-1.9	2.0	-0.9	-1.0
Supplements: Zinc	1.1	1.2	2.2	1.5	1.3	-0.1	-0.9
Medication: Co-codamol	0.4	0.4	0.9	0.2	1.0	-0.8	-0.1
Medication: Metformin	1.1	1.5	5.7	-2.4	0.2	-0.1	-0.5
Diabetes (father)	0.4	0.5	1.1	-1.0	-0.4	0.6	0.5
Diabetes (mother)	1.1	1.5	3.5	0.2	-1.5	-1.9	-0.4
Severe depression (siblings)	1.2	1.3	2.1	1.1	-1.5	1.3	0.6
Pack years adult smoking proportion	0.8	1.3	3.3	-1.8	0.5	0.6	1.1
Impedance of leg (right)	0.5	2.5	5.4	1.7	-2.3	0.4	1.2
Leg fat-free mass (left)	0.6	3.1	6.1	-1.3	2.5	-1.6	-1.5
Trunk fat percentage	0.8	3.4	6.0	-2.4	1.0	-2.4	-0.9
Hand grip strength (right)	0.4	1.1	2.0	0.4	0.5	-1.3	-1.4
Townsend deprivation index at recruitment	0.5	0.6	1.4	-0.4	1.0	1.2	0.3
Current tobacco smoking	1.7	2.7	8.6	-2.9	0.0	1.4	0.5
Average weekly fortified wine intake	2.0	2.3	4.7	1.9	-2.2	0.8	0.7
Maternal smoking around birth	0.7	1.1	2.3	-0.1	1.4	1.5	0.4
Fed-up feelings	0.2	0.3	0.7	-0.3	-0.9	-0.8	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	0.7	-0.8	0.1	-0.9	0.6
Relative age voice broke	0.7	1.0	2.6	1.6	-0.7	1.0	-0.0
Taking other prescription medications	2.2	3.4	4.7	-1.7	2.2	-2.1	-1.2
Age when periods started (menarche)	4.3	10.2	29.3	5.4	0.7	-3.0	-1.6
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.8	0.5	-1.3	1.9	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.3	-0.3	0.2	-1.1	-0.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.8	-1.7	1.1	0.8	0.3
Qualifications: CSEs or equivalent	0.5	0.7	1.2	0.4	1.1	-1.0	-0.5
Serious illness, injury or assault to yourself	0.8	1.0	2.1	-1.4	0.8	-0.9	-0.5
High blood pressure	0.4	1.1	4.1	-2.0	0.2	-0.2	0.3
Hayfever, allergic rhinitis or eczema	1.4	3.0	5.6	1.9	1.1	2.4	1.2
Multivitamins +/- minerals	1.4	1.8	3.5	1.2	-1.9	0.6	1.3
Stomach or abdominal pain in last month	1.1	1.4	2.1	-1.5	-1.3	0.6	1.2
Supplements: Glucosamine	0.6	0.7	1.8	-0.0	-1.4	0.6	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	0.2	0.5	-0.1	-1.0
Medication: Atenolol	1.6	1.9	3.9	0.6	1.5	-1.1	-2.0
Medication: Levothyroxine sodium	0.8	1.3	2.3	-0.5	1.3	-1.5	-0.9
Sitting height	0.1	1.0	2.5	1.2	1.6	0.2	-0.1
Chronic bronchitis/emphysema (father)	0.5	0.5	1.2	-1.1	-0.6	0.8	0.1
High blood pressure (mother)	0.8	1.1	1.8	-1.4	0.7	-1.2	-0.8
Body mass index (BMI)	0.5	2.2	7.2	-2.7	1.0	-0.7	-0.3
Impedance of leg (left)	0.4	1.7	3.2	1.8	-1.7	0.0	0.9
Leg predicted mass (left)	0.6	3.1	5.8	-1.3	2.4	-1.6	-1.5
Trunk fat mass	0.7	3.1	4.8	-2.1	1.5	-2.2	-1.0
Waist circumference	0.2	0.7	1.8	-1.3	0.7	0.2	0.7
Number of incorrect matches in round	0.2	0.3	0.7	-0.8	0.4	0.7	0.1
Past tobacco smoking	0.4	0.7	2.0	-0.8	-1.4	0.5	0.3
Alcohol usually taken with meals	0.9	1.5	3.9	1.1	-2.0	-0.9	-0.2
Nervous feelings	0.5	0.8	2.5	1.6	-0.2	0.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.1	-2.0	0.6	1.4	1.7
Hearing difficulty/problems with background noise	0.4	0.7	1.5	0.9	-0.5	0.1	1.2
Hair/balding pattern: Pattern 2	0.6	0.8	1.6	1.0	0.5	-1.3	-0.5
Had menopause	1.0	1.2	3.0	-0.4	-0.4	-1.2	-1.7
Had other major operations	2.0	2.4	8.4	-2.9	0.6	-0.3	-0.9
Forced vital capacity (FVC)	0.3	1.1	3.7	1.9	0.3	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-1.4	0.1	-0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.5	-1.6	0.8	0.3	-0.2
Qualifications: None of the above	0.9	1.9	4.1	-2.0	1.5	-0.8	-0.9
Financial difficulties in last 2 years	2.4	3.2	4.7	-1.4	2.1	-1.4	-2.2
Mouth/teeth dental problems	0.5	0.8	1.5	1.2	-0.8	-0.9	-0.4
Heart attack	1.0	1.3	3.7	-0.4	0.1	-1.9	-1.1
Allergy	0.6	1.4	2.8	-0.7	-1.1	-1.7	-1.1
Pain all over the body in last month	0.7	0.7	2.4	0.6	-0.3	0.1	1.6
Diabetes (self-reported)	0.6	0.9	3.5	-1.9	0.3	0.1	0.2
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	7.6	0.3	0.6	2.8	2.2
Medication: Ramipril	0.3	0.4	1.1	-1.1	-0.5	-0.2	-0.1
Medication: Simvastatin	1.2	1.8	5.2	-2.3	0.9	-1.0	-0.6
Fluid intelligence score	0.5	1.1	3.7	0.3	-0.6	1.9	-0.1
Illnesses of siblings	0.9	1.3	3.0	1.7	1.3	-0.3	-0.7
Neuroticism score	0.2	0.3	0.8	-0.9	-0.0	-0.6	0.5
Weight	0.5	2.7	5.3	-1.4	2.3	-1.5	-1.0
Impedance of arm (right)	0.3	1.5	3.9	2.0	-0.6	-1.3	0.3
Arm fat percentage (right)	0.4	1.6	4.2	-2.0	0.8	-1.3	-0.2
Trunk fat-free mass	0.3	1.8	5.7	0.3	2.4	-0.4	-1.1
Hip circumference	1.2	5.0	8.3	-1.0	2.5	-2.9	-2.1
Time employed in main current job	0.7	0.8	3.2	-0.1	-0.3	-1.8	-0.1
Alcohol intake versus 10 years previously	0.5	0.8	1.9	-1.4	0.9	0.7	0.1
Father’s age at death	0.2	0.3	0.6	-0.0	-0.6	0.8	-0.1
Worrier / anxious feelings	0.0	0.0	0.1	0.0	-0.2	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	0.7	-0.4	-0.6	0.8
Falls in the last year	0.4	0.5	0.7	-0.5	-0.8	-0.8	-0.7
Hair/balding pattern: Pattern 3	0.9	1.3	3.6	-1.9	-0.7	0.8	-0.6
Number of live births	0.9	1.3	2.7	-0.8	1.6	-1.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.6	2.1	-0.4	-1.3	-0.3
Pulse rate	0.8	1.3	2.3	-1.0	-0.9	1.1	1.5
Happiness	0.6	0.7	1.6	0.4	1.1	1.3	-0.0
Noisy workplace	1.1	1.3	2.6	-1.4	-0.7	-0.4	1.6
Qualifications: A levels/AS levels or equivalent	1.1	2.3	5.8	2.4	-1.6	0.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.0	-0.3	-0.2	0.6
Mouth/teeth dental problems: Dentures	1.8	3.0	4.9	-2.2	1.4	-1.6	-1.7
Asthma	0.1	0.3	0.8	-0.2	0.9	0.3	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.7	0.1	-1.3	-1.6	-0.6
Medication: Cholesterol lowering	0.6	0.9	3.0	-0.5	0.2	-1.7	-0.6
Depression (self-reported)	1.1	1.3	2.5	0.1	1.1	-1.2	-1.6
Medication: Lansoprazole	0.3	0.3	1.2	-0.3	-0.2	-0.1	1.1
Prospective memory result	0.5	0.6	1.9	-1.4	-0.4	-0.2	0.4
Lung cancer (father)	0.4	0.4	0.9	0.9	-0.9	-0.1	-0.0
Illnesses of mother	0.2	0.2	0.6	0.8	0.4	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.7	2.8	0.5	-1.0	-0.0
Pulse wave Arterial Stiffness index	0.4	0.5	0.8	-0.8	-0.3	0.7	0.9
Impedance of arm (left)	0.2	0.8	1.5	1.2	-0.8	-1.0	0.4
Arm fat mass (right)	0.5	2.0	4.0	-2.0	1.4	-1.4	-0.4
Trunk predicted mass	0.3	1.9	5.9	0.5	2.4	-0.4	-1.1
Standing height	0.5	4.8	7.7	2.4	2.8	-1.8	-1.6
Length of working week for main job	0.9	1.0	2.0	0.0	0.3	-1.4	-1.4
Exposure to tobacco smoke at home	1.7	1.9	3.9	-2.0	-0.7	-1.9	-0.2
Breastfed as a baby	0.2	0.3	0.5	-0.2	0.7	0.4	-0.6
Tense / ‘highly strung’	0.2	0.4	1.1	-0.6	-0.3	0.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.3	0.7	0.2	0.5
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.4	0.5	-1.0	-0.4
Birth weight of first child	0.5	0.9	2.1	-1.4	0.8	-0.1	-1.0
Peak expiratory flow (PEF)	0.2	0.5	1.2	1.1	-0.7	-0.6	0.0
Pulse wave reflection index	0.6	0.7	1.7	0.9	-1.3	0.3	0.5
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.7	-1.0	1.3	0.8	0.6
Loud music exposure frequency	1.0	1.0	3.6	0.4	1.9	0.6	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.8	0.3	-0.6	-0.7	-1.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.0	0.6	-0.5	1.7	1.4
Blood clot in the leg (DVT)	0.9	1.2	2.5	-1.3	0.1	0.9	1.6
Medication: Paracetamol	0.3	0.4	1.3	-0.0	-0.1	1.1	0.7
Headache pain in last month	0.4	0.7	1.4	1.2	0.4	-0.8	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	1.1	-0.5	1.1	0.4
Glaucoma (self-reported)	0.7	0.8	2.3	-0.5	-0.7	-1.5	-0.4
Gout (self-reported)	0.3	0.4	1.1	0.6	-1.1	0.1	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	0.1	0.6	-0.9	-0.4
Medication: Amlodipine	0.3	0.5	1.6	-1.3	0.4	-0.5	-0.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	-0.4	-0.4	1.1	0.2
Birth weight	3.6	7.8	11.7	-2.2	3.1	-3.4	-2.4
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.7	-0.6	-1.1	1.1	1.7
High blood pressure (siblings)	0.1	0.1	0.4	-0.1	-0.6	-0.1	0.3
Forced vital capacity (FVC), Best measure	0.5	1.9	6.6	2.6	1.0	-0.4	-0.3
Body fat percentage	0.6	2.2	5.6	-2.4	0.6	-1.6	-0.4
Leg fat percentage (right)	0.3	1.3	4.5	-2.1	-0.3	-0.5	0.4
Arm fat-free mass (right)	0.4	2.2	5.8	-0.7	2.4	-0.8	-1.4
Exposure to tobacco smoke outside home	0.5	0.7	1.2	-0.8	-0.7	-1.1	0.6
Comparative body size at age 10	0.4	1.0	2.1	-1.0	0.9	-1.5	-0.5
Number of full brothers	0.9	1.1	2.0	-1.2	-1.4	0.4	1.0
Worry too long after embarrassment	1.7	2.8	7.4	0.4	-0.1	-2.7	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	0.6	1.3	1.1	0.3
Wheeze or whistling in the chest in last year	0.7	1.3	3.1	-1.8	0.1	1.3	0.5
Number of children fathered	0.2	0.2	0.3	0.3	0.6	-0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	1.9	1.4	1.4	-0.5	-1.0
Age at first live birth	0.9	1.5	2.8	1.7	-0.7	1.1	1.3
Pulse wave peak to peak time	0.7	0.8	1.3	0.9	0.5	-0.9	-1.1
Health satisfaction	2.1	2.7	6.4	-2.5	1.9	-0.1	-0.9
Shortness of breath walking on level ground	1.3	1.5	2.7	-1.2	0.7	-1.6	-1.2
Qualifications: College or University degree	1.3	4.0	9.5	3.1	-2.2	1.3	-0.2
Eye problems/disorders: None of the above	2.0	2.3	8.8	0.4	-0.3	3.0	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.6	0.3	0.4	-0.4
Emphysema/chronic bronchitis	1.2	1.3	2.1	-1.5	-0.9	0.9	1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.9	-0.2	-0.2	1.4	1.0
Neck or shoulder pain in last month	2.0	2.8	4.3	-0.9	1.7	-2.1	-1.8
Medication: Blood pressure	0.1	0.1	0.3	-0.4	0.6	-0.2	0.2
Angina (self-reported)	1.1	1.5	1.8	1.3	1.3	-1.3	-0.9
Migraine (self-reported)	1.4	1.8	4.5	2.1	0.3	-1.1	-1.2
Medication: Ibuprofen	1.0	1.2	2.1	-0.4	-1.5	-1.5	-0.6
Medication: Allopurinol	0.3	0.4	0.8	-0.3	-0.6	-0.9	-0.7
Medication: Omeprazole	1.7	2.0	7.7	-0.5	2.8	0.4	-0.1
Medication: Seretide 50 evohaler	0.4	0.5	1.2	-1.1	0.2	0.4	-0.8
Mean time to correctly identify matches	0.6	1.1	3.0	0.0	1.7	-1.1	-0.3
Heart disease (mother)	0.3	0.3	0.5	-0.5	-0.6	-0.7	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.1	0.3	-0.8	-0.1
Whole body fat mass	0.6	2.6	4.6	-2.1	1.4	-1.7	-0.8
Leg fat mass (right)	0.5	2.0	5.8	-2.4	0.9	-1.2	-0.4
Arm predicted mass (right)	0.4	2.2	5.7	-0.8	2.4	-0.8	-1.4
Pulse rate, automated reading	1.6	5.3	12.4	0.2	-1.3	3.5	2.6
Alcohol intake frequency.	1.1	2.6	4.8	0.9	2.2	-1.2	-1.9
Comparative height size at age 10	0.3	1.6	3.4	-0.4	1.0	1.8	1.4
Number of full sisters	0.5	0.6	1.9	-0.3	1.4	0.6	-0.3
Suffer from ‘nerves’	0.1	0.1	0.3	0.2	0.2	0.1	0.6
Overall health rating	0.9	1.9	2.9	-1.4	1.3	-0.9	-1.7
Chest pain or discomfort	0.5	0.7	1.4	-0.4	-1.1	-1.2	0.4
Had major operations	0.6	0.8	1.4	1.2	-0.8	-1.0	-0.1
Age at last live birth	0.5	0.7	2.2	1.5	0.0	-0.1	0.8
Family relationship satisfaction	0.4	0.5	0.7	0.7	0.8	0.6	-0.7
Leg pain on walking	1.0	1.3	4.0	-0.3	0.0	1.1	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	-0.4	0.5	-1.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.8	0.4	-0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	0.7	-1.0	-0.3	0.2
Medication: Aspirin	2.3	3.1	5.9	0.7	0.5	-2.4	-2.4
Supplements: Vitamin C	0.7	0.9	2.0	0.0	1.2	-0.1	-1.4
Knee pain experienced in last month	1.3	2.0	4.2	-1.5	0.6	-2.1	-1.2
Hypertension (Self-reported)	0.3	0.8	2.8	-1.7	0.4	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	0.7	-0.2	0.3	1.1
Illnesses of father: Heart disease	0.7	1.0	3.6	-1.9	0.0	0.3	0.4
Illnesses of siblings: Diabetes	2.6	3.1	7.2	-2.7	-1.0	1.5	1.5
Smoking status: Previous	0.6	1.0	2.2	1.5	1.2	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.6	1.5	1.6	-0.4	-0.9
Whole body fat-free mass	0.4	2.3	6.5	-0.3	2.5	-0.9	-1.3
Leg fat-free mass (right)	0.7	3.7	7.8	-1.1	2.8	-1.8	-1.6
Arm fat percentage (left)	0.5	2.1	5.6	-2.4	0.9	-1.4	-0.3
Average weekly red wine intake	1.4	2.1	4.1	2.0	-1.3	-1.3	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.2	-0.1	-0.2	-0.4
Mood swings	0.5	0.9	1.9	-1.3	0.2	-1.4	-0.1
Loneliness, isolation	0.5	0.7	2.4	-0.1	1.5	-0.3	-0.5
Long-standing illness, disability or infirmity	0.7	1.0	2.1	-0.7	1.5	-0.9	-0.8
Ever had bowel cancer screening	2.5	2.9	7.7	-0.9	1.2	-1.3	-2.8
Diabetes diagnosed by doctor	0.8	1.4	3.6	-1.9	0.2	-0.7	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	0.4	0.1	0.3
Friendships satisfaction	0.3	0.4	0.9	-0.1	0.5	0.6	-0.9
Qualifications: nursing, teaching	1.7	2.6	7.8	2.8	-1.4	0.8	0.6
Commuting to job workplace: Walk	1.0	1.0	2.0	0.7	-1.3	-1.4	-0.4
Eye problems/disorders: Cataract	0.8	0.9	2.7	0.3	-0.5	-0.8	1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	1.2	0.3	0.6	0.8
Medication for cholesterol	2.3	3.6	5.5	2.3	-1.7	1.4	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.4	-1.5	0.0	-0.4	-0.7
Back pain experienced in last month	0.7	1.0	3.6	-0.1	0.5	-1.9	0.1
Mineral and other dietary supplements	1.5	2.1	6.8	-0.5	2.6	-0.7	-0.9
Breast cancer (self-reported)	1.1	1.3	2.1	-1.4	0.8	0.5	-1.4
Asthma (self-reported)	0.1	0.2	0.5	-0.1	0.7	0.1	-0.5
Osteoporosis (self-reported)	0.5	0.6	1.1	-1.0	0.4	-1.1	-0.5
Osteoarthritis (self-reported)	0.3	0.3	0.7	-0.5	0.5	-0.9	-0.2
Medication: Aspirin	2.5	3.2	6.0	0.9	0.3	-2.5	-2.4
Medication: Gliclazide	0.2	0.2	0.4	-0.6	-0.3	-0.6	-0.2
Illnesses of father: None of the above (group 1)	1.6	2.0	7.0	2.7	-0.2	-0.7	-0.6
Smoking status: Current	1.6	2.5	8.6	-2.9	-0.3	1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	1.0	0.2	-0.5	-0.9
Whole body water mass	0.4	2.4	6.9	-0.3	2.6	-0.9	-1.4
Leg predicted mass (right)	0.7	3.9	8.2	-1.2	2.9	-1.7	-1.7
Arm fat mass (left)	0.6	2.4	4.5	-2.1	1.6	-1.4	-0.7
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	-0.6	1.1	-0.3	0.6
Average weekly champagne plus white wine intake	0.4	0.5	0.9	0.8	-0.7	1.0	0.2
Miserableness	0.1	0.2	0.6	-0.1	-0.1	-0.8	-0.2
Guilty feelings	0.5	0.7	2.0	0.2	1.4	0.4	-0.8
Wears glasses or contact lenses	0.8	0.9	2.4	-0.7	0.9	1.6	-0.4
Ever taken oral contraceptive pill	0.4	0.5	1.2	-0.7	0.1	-0.4	1.1
Hearing aid user	0.5	0.6	2.1	0.4	-0.2	-0.3	-1.5
Mother’s age at death	0.7	0.8	2.1	0.6	0.7	-0.6	-1.4
Financial situation satisfaction	0.2	0.2	0.7	-0.0	0.3	-0.8	0.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	0.8	0.2	-0.9	-0.8
Commuting to job workplace: Public transport	0.5	0.6	1.6	1.3	-0.0	-0.6	-0.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	-1.2	0.2	-0.8	-1.0
Medication: Blood pressure	0.5	0.9	1.8	-0.5	0.8	-1.0	-1.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.3	-0.0	0.1	0.5
Supplements: Fish oil (including cod liver oil)	1.8	2.3	6.9	-0.5	-2.6	1.0	1.1
High cholesterol (Self-reported)	0.5	0.8	2.0	-1.4	-0.1	-0.8	0.7
Medication: Bendroflumethiazide	0.6	0.9	2.0	1.0	0.8	-0.2	-1.4
Medication: Paracetamol	0.2	0.4	0.7	-0.4	-0.6	0.8	0.6
Medication: Lisinopril	0.5	0.6	1.6	-1.3	-0.9	0.1	0.4
Medication: Atorvastatin	0.5	0.6	1.5	0.4	0.4	-1.2	-0.9
Illnesses of father: High blood pressure	1.0	1.2	2.0	-1.1	-1.4	0.3	1.2
Alcohol drinker status: Never	2.2	2.6	6.8	1.8	0.2	-0.5	-2.6
Ever smoked	0.2	0.3	0.7	-0.3	0.8	0.3	0.5
Basal metabolic rate	0.5	2.6	6.9	-0.5	2.6	-1.1	-1.3
Leg fat percentage (left)	0.4	1.4	5.1	-2.2	0.3	-0.7	0.2
Arm fat-free mass (left)	0.5	2.8	7.6	-0.4	2.8	-0.8	-1.7
Number of operations (self-reported)	0.9	1.4	2.4	-1.1	-1.5	0.3	1.4
Average weekly beer plus cider intake	0.4	0.6	1.5	-0.0	0.5	0.7	1.2
Irritability	0.3	0.4	1.6	-0.4	1.2	-0.1	-0.2
Risk taking	0.2	0.3	1.1	0.1	0.1	1.1	-0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.2	-0.3	1.0	-2.1	-1.8
Fractured/broken bones in last 5 years	0.1	0.2	0.3	0.2	-0.2	0.6	0.5
Age started oral contraceptive pill	0.5	0.7	1.8	-0.1	-0.9	1.3	0.5
Diastolic blood pressure, automated reading	0.5	1.4	3.4	-1.8	1.5	0.2	0.3
Ever depressed for a whole week	1.9	2.3	7.8	0.6	2.8	1.0	-0.6
Unable to work because of sickness or disability	1.6	2.1	3.7	-1.9	1.7	1.1	0.9
Commuting to job workplace: Cycle	0.3	0.4	1.0	1.0	0.2	0.7	-0.4
Myopia	0.8	1.2	4.3	2.1	-0.7	0.0	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.2	1.8	-0.4	0.7	0.3
Cholesterol lowering medication	2.6	3.8	8.5	-2.9	1.3	-1.3	-1.8
Medication: Omeprazole (e.g. Zanprol)	2.1	2.6	9.5	0.1	3.1	0.8	0.4
Pain experienced in last month	0.5	0.8	2.4	-0.5	-0.8	1.6	-0.1
Supplements: Calcium	0.3	0.3	0.7	0.2	0.8	0.2	-0.8
Basal cell carcinoma (self-reported)	3.0	3.5	8.1	0.9	-0.7	2.2	2.8
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.4	-0.2	0.3	-2.1	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.8	-1.7	-0.0	0.6	1.2
Heart disease (siblings)	0.5	0.6	1.7	-1.3	-0.5	0.5	0.1
Alcohol drinker status: Previous	1.3	1.5	3.2	1.8	0.8	0.6	1.3
Pack years of smoking	1.0	1.4	4.3	-2.1	0.6	0.6	0.8
Impedance of whole body	0.2	1.2	2.5	1.6	-1.3	-0.5	0.7
Leg fat mass (left)	0.6	2.5	6.6	-2.6	1.1	-1.3	-0.5
Arm predicted mass (left)	0.4	2.2	6.4	-0.2	2.5	-0.7	-1.4