Hub : Genes

SMAD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.0720	0.0340	9.6e-03	-0.005	NA	-0.003	NA	-0.004	9.1e-01	NA	5.4e-01	NA	7.1e-01
2	GTEx	Spleen	0.3270	0.1050	3.8e-04	0.100	NA	0.075	NA	0.064	1.6e-03	NA	5.6e-03	NA	9.9e-03
3	YFS	Blood	0.0306	0.0090	3.3e-08	0.028	0.024	0.030	0.025	0.032	1.1e-09	1.8e-08	3.9e-10	7e-09	1.2e-10
4	TCGA	Brain Lower Grade Glioma	0.0556	0.0377	4.7e-03	0.018	0.010	0.008	NA	0.012	3.5e-03	2.3e-02	3.6e-02	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	0.9	1.1	-0.6	1.1	1.1	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.3	2.2	-1.0	1.4	1.5	-0.2
Depressed Affect (Nagel 2018)	1.4	3.0	5.2	1.4	-2.1	-2.3	0.4
Depression (Nagel 2018)	1.5	2.3	5.4	0.7	-1.8	-2.3	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.7	3.2	-0.4	1.8	1.7	-0.7
Neuroticism (Nagel 2018)	1.2	2.8	4.0	1.7	-1.8	-2.0	1.2
Schizophrenia (2018)	0.3	0.7	1.1	-0.7	0.9	1.0	0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	-0.3	0.6	0.9	-0.8
Worry (Nagel 2018)	0.2	0.4	0.8	0.5	-0.5	-0.5	0.9
Alzheimer’s Disease (in mother)	2.2	2.6	4.2	1.4	-1.4	-1.6	2.0
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.2	0.5	0.2	0.5
Alzheimer’s Disease (including proxy)	1.2	1.7	4.0	1.0	-0.9	-1.1	2.0
Crohns Disease (2017)	3.0	6.5	9.1	-2.3	2.7	3.0	-2.1
Irritable Bowel Disease (IBD)	4.9	11.7	13.0	-3.1	3.3	3.6	-3.6
Ulcerative Colitis (UC)	4.0	7.6	12.4	-2.4	2.4	2.5	-3.5
Major Depression (MDD)	0.4	0.5	1.0	0.5	-1.0	-0.8	-0.2
Reaction Time	2.1	3.9	6.2	-2.2	2.5	2.1	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.9	0.3	1.0	1.4	-0.1
Breast Cancer	0.3	0.8	2.4	0.5	-0.3	-0.5	-1.6
Ovarian Cancer	1.8	2.4	3.5	1.6	-1.9	-1.3	1.3
Prostate Cancer	1.0	1.4	3.8	0.6	-2.0	-1.1	0.6
Age at First Birth	0.9	1.3	2.3	0.5	-1.3	-1.0	1.5
Bipolar Disorder (2011)	2.9	2.8	3.8	-2.0	1.6	1.9	-1.1
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.3	0.2	0.4	0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.1	0.6	-0.1	-0.3	1.0
Crohns Disease (2012)	1.9	3.1	3.9	-1.3	1.9	2.0	-1.7
Mean Putamen Volume	0.3	0.4	0.6	-0.8	0.8	0.4	-0.5
Fasting Glucose	0.5	0.6	0.9	0.4	-0.8	-0.9	0.8
HbA1C	0.1	0.2	0.5	0.3	0.2	-0.1	0.7
HDL Cholesterol	0.5	0.8	1.3	0.5	-1.2	-0.9	-0.8
LDL Cholesterol	0.3	0.5	1.3	-0.7	-0.3	-0.6	1.1
Lupus	0.7	1.0	1.9	1.0	-1.4	-0.9	0.7
Neuroticism (2016)	3.1	4.4	8.8	3.0	-1.7	-1.7	1.7
Primary Biliary Cirrhosis	0.8	1.2	2.8	0.8	-0.9	-0.7	1.7
Rheumatoid Arthritis	0.5	0.8	1.6	-0.7	0.5	0.8	1.3
Schizophrenia (2014)	1.0	2.1	3.5	-1.2	1.9	1.9	-0.4
Triglycerides	0.3	0.5	1.3	-0.3	-0.6	-0.4	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	-0.2	-0.8	-0.9	1.1
Ulcerative Colitis	6.1	8.8	13.0	-2.7	2.7	2.8	-3.6
Blood Eosinophil Count	3.4	26.4	35.5	-4.2	5.9	6.0	-4.2
Blood Platelet Count	0.7	8.3	9.6	2.7	-2.8	-2.9	3.1
Blood Red Count	0.1	0.8	1.4	0.5	-1.2	-1.2	0.1
Blood White Count	0.6	4.6	7.1	-2.7	2.3	2.4	-0.5
Heel T-Score	0.6	5.0	13.5	-0.5	1.9	1.6	-3.7
BMI	0.1	0.8	1.4	0.3	-0.9	-0.8	1.2
Height	0.4	7.8	9.8	-2.2	3.1	3.1	-2.6
Waist Hip Ratio (WHR)	0.2	1.1	3.5	0.4	-0.6	-0.6	1.9
Systolic Blood Pressure	0.9	4.7	11.5	-3.4	2.0	1.7	-0.7
Smoking Status	0.4	0.9	2.1	-0.2	-1.5	-1.2	-0.3
Allergy or Eczema	8.4	22.1	31.5	-3.9	5.6	5.4	-3.6
Cardiovascular Disease	1.7	5.6	10.3	-3.2	2.5	2.4	-0.2
Hypothyroidism (self reported)	1.3	3.1	4.0	2.0	-1.4	-1.7	1.8
Respiratory disease	5.7	12.7	16.7	-4.1	3.6	3.9	-2.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.9	0.3	-0.2	-0.4	2.2
Lung FEV1/FVC ratio	0.0	0.2	0.3	-0.6	-0.6	-0.1	0.2
Lung FVC	0.3	1.5	3.6	-0.0	1.5	1.9	-0.4
Neuroticism	1.0	2.4	3.7	1.5	-1.9	-1.9	0.4
Chronotype (morning person)	0.2	0.4	1.5	-0.1	0.2	0.4	-1.2
Hair Pigment	0.0	1.1	2.2	0.3	-1.2	-1.5	0.8
Tanning	0.0	0.1	0.5	-0.1	-0.0	0.0	0.7
Hand grip strength (left)	0.4	1.0	2.2	-0.4	1.5	1.2	-0.4
Number of treatments/medications taken	2.8	5.1	8.1	-2.8	2.4	2.4	-1.0
Average weekly spirits intake	1.8	2.2	3.9	1.2	-1.4	-2.0	1.2
Sensitivity / hurt feelings	1.1	1.9	3.3	1.8	-0.8	-1.1	1.5
Frequency of depressed mood in last 2 weeks	3.3	4.6	8.7	0.8	-2.9	-3.0	0.7
Hearing difficulty/problems: Yes	0.5	0.8	2.0	-0.2	0.6	0.9	-1.4
Relative age of first facial hair	1.3	2.7	4.1	0.3	-1.8	-1.8	2.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.1	-1.8	0.1	0.6	1.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	1.0	-0.1	-0.1	0.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	-0.8	-0.1	-0.1	-0.6
Systolic blood pressure, automated reading	0.3	0.8	1.8	-1.2	0.1	-0.1	1.4
Eye problems/disorders: Diabetes related eye disease	6.0	6.5	9.4	3.1	-2.1	-2.4	2.6
Angina	0.1	0.1	0.2	-0.4	0.3	0.2	0.4
Medication for hormone replacement therapy	1.3	1.5	2.2	0.4	-1.5	-1.4	1.2
Vitamin and mineral supplements	0.3	0.4	0.7	0.8	-0.7	-0.5	0.4
Supplements: Zinc	0.7	0.8	1.8	1.3	-0.7	-0.8	-0.4
Medication: Co-codamol	0.4	0.4	1.3	0.5	0.3	0.4	1.1
Medication: Metformin	0.0	0.1	0.1	-0.4	0.1	-0.2	-0.1
Diabetes (father)	0.3	0.4	0.9	-0.9	0.3	0.4	-0.6
Diabetes (mother)	0.7	0.9	1.5	-1.2	0.5	1.1	0.8
Severe depression (siblings)	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.2
Pack years adult smoking proportion	0.3	0.4	0.5	0.4	0.7	0.6	-0.7
Impedance of leg (right)	0.1	0.5	0.9	-0.6	-0.8	-0.9	0.3
Leg fat-free mass (left)	0.1	0.4	1.0	-0.0	0.5	1.0	-0.4
Trunk fat percentage	0.5	2.1	3.2	0.9	-1.8	-1.6	1.4
Hand grip strength (right)	0.2	0.4	0.9	-0.3	0.8	0.9	0.2
Townsend deprivation index at recruitment	1.8	2.5	3.7	-1.9	1.4	1.5	-1.4
Current tobacco smoking	0.2	0.3	0.8	0.5	-0.2	0.4	-0.9
Average weekly fortified wine intake	0.5	0.5	1.2	0.0	-0.7	-1.1	0.7
Maternal smoking around birth	0.2	0.4	1.2	-1.1	-0.1	-0.1	-0.4
Fed-up feelings	1.0	1.8	3.0	1.2	-1.6	-1.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.0	0.4	-1.5	-1.7	0.3
Relative age voice broke	0.2	0.3	0.8	0.3	-0.2	-0.2	0.9
Taking other prescription medications	1.0	1.5	2.1	-1.3	1.2	1.5	0.9
Age when periods started (menarche)	0.1	0.3	0.6	0.3	-0.0	0.8	-0.8
Bilateral oophorectomy (both ovaries removed)	3.6	4.2	5.9	1.9	-2.0	-2.4	1.9
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	7.6	-1.2	2.2	2.4	-2.7
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.4	-1.6	1.5	1.4	-2.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.3	0.1	0.2	-0.4
Serious illness, injury or assault to yourself	1.3	1.6	3.0	0.6	-1.2	-1.7	1.2
High blood pressure	3.0	8.3	14.6	-3.8	3.1	2.9	-1.1
Hayfever, allergic rhinitis or eczema	7.8	17.0	25.7	-2.9	5.1	5.0	-3.0
Multivitamins +/- minerals	0.8	1.0	2.5	-1.6	0.9	0.6	-0.5
Stomach or abdominal pain in last month	0.3	0.3	0.8	0.5	-0.6	-0.9	0.2
Supplements: Glucosamine	0.1	0.1	0.3	0.6	0.2	-0.0	0.2
Diverticular disease/diverticulitis (self-reported)	3.9	4.6	6.4	-1.6	2.3	2.5	-2.1
Medication: Atenolol	1.8	2.3	5.1	-2.3	1.1	1.7	-0.2
Medication: Levothyroxine sodium	0.1	0.2	0.8	0.9	-0.1	0.0	-0.0
Sitting height	0.3	2.1	4.9	-0.1	1.2	1.5	-2.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	1.2	-0.7	-1.0	-0.5
High blood pressure (mother)	0.9	1.2	2.7	0.8	-1.6	-1.1	0.7
Body mass index (BMI)	0.1	0.5	1.2	0.4	-0.8	-0.4	1.1
Impedance of leg (left)	0.0	0.2	0.4	-0.6	-0.3	-0.5	0.4
Leg predicted mass (left)	0.1	0.3	0.9	0.0	0.4	0.9	-0.3
Trunk fat mass	0.2	1.0	1.6	0.7	-1.3	-1.0	1.0
Waist circumference	0.1	0.3	0.6	0.1	-0.8	-0.5	0.7
Number of incorrect matches in round	4.2	6.9	9.1	2.7	-2.6	-3.0	2.1
Past tobacco smoking	0.5	0.9	1.7	0.1	1.2	1.3	0.6
Alcohol usually taken with meals	0.1	0.1	0.3	-0.6	0.3	0.4	-0.2
Nervous feelings	0.2	0.3	0.6	0.1	-0.8	-0.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	3.9	2.0	-1.6	-1.9	1.5
Hearing difficulty/problems with background noise	0.3	0.5	1.3	0.6	-1.2	-0.6	0.2
Hair/balding pattern: Pattern 2	0.5	0.7	1.1	1.0	0.7	0.4	1.1
Had menopause	1.0	1.2	2.7	0.9	-0.9	-1.6	0.7
Had other major operations	1.3	1.6	2.6	0.9	-1.6	-1.0	1.4
Forced vital capacity (FVC)	0.9	3.4	7.3	-0.6	2.4	2.7	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	6.1	-2.1	1.9	2.5	-1.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	-0.5	0.2	-0.1	-1.0
Qualifications: None of the above	0.3	0.7	1.3	0.2	-1.2	-0.8	0.9
Financial difficulties in last 2 years	1.0	1.3	3.9	-2.0	-0.1	-0.2	-1.2
Mouth/teeth dental problems	1.7	2.6	4.5	1.7	-1.3	-1.1	2.1
Heart attack	1.5	1.9	3.1	-1.4	1.8	1.2	-1.1
Allergy	9.2	21.2	32.7	3.2	-5.6	-5.7	3.3
Pain all over the body in last month	1.2	1.3	2.4	-0.2	0.9	1.4	-1.6
Diabetes (self-reported)	0.5	0.8	1.0	0.9	-0.7	-0.9	1.0
Hayfever/allergic rhinitis (self-reported)	3.6	4.7	7.0	-2.6	2.1	2.4	-1.3
Medication: Ramipril	0.8	1.0	3.3	-1.8	0.5	0.1	0.6
Medication: Simvastatin	0.8	1.2	2.4	0.6	-1.2	-1.5	0.8
Fluid intelligence score	0.3	0.5	1.0	0.8	0.7	1.0	0.3
Illnesses of siblings	0.4	0.6	1.1	-1.0	0.3	0.8	-0.7
Neuroticism score	1.5	3.2	4.4	2.1	-2.0	-2.0	0.6
Weight	0.0	0.1	0.3	-0.0	0.0	0.5	0.1
Impedance of arm (right)	0.3	1.5	2.9	0.8	-1.3	-1.7	0.9
Arm fat percentage (right)	0.3	1.2	2.0	0.6	-1.3	-0.9	1.4
Trunk fat-free mass	0.6	3.3	6.2	-1.2	2.0	2.5	-1.2
Hip circumference	0.0	0.1	0.1	-0.4	0.1	0.3	-0.1
Time employed in main current job	0.3	0.4	1.3	-0.2	0.3	0.2	-1.1
Alcohol intake versus 10 years previously	0.5	0.7	1.4	0.2	-1.2	-0.7	1.0
Father’s age at death	1.5	2.1	3.8	2.0	-1.3	-1.5	-0.6
Worrier / anxious feelings	0.4	0.8	1.6	-0.7	1.2	1.0	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	3.7	1.3	-1.9	-1.9	-0.1
Falls in the last year	0.3	0.4	0.7	0.4	-0.5	-0.9	0.6
Hair/balding pattern: Pattern 3	0.2	0.4	0.8	-0.9	0.5	0.3	-0.6
Number of live births	0.1	0.1	0.3	-0.4	-0.2	-0.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.9	-0.3	1.5	2.2	0.2
Pulse rate	0.0	0.1	0.2	0.4	-0.3	-0.2	-0.1
Happiness	0.3	0.4	0.8	-0.3	0.6	0.9	-0.6
Noisy workplace	0.1	0.2	0.4	-0.3	-0.3	-0.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	-1.0	1.4	0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	1.9	0.4	-1.1	-1.4	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.2	-0.7	-0.9	-0.3
Asthma	7.2	14.2	19.9	-3.8	3.9	4.5	-2.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.2	-2.1	0.9	0.6	-0.3
Medication: Cholesterol lowering	0.8	1.3	4.3	-2.1	0.8	0.3	0.1
Depression (self-reported)	0.4	0.5	0.9	-0.8	0.5	0.9	-0.2
Medication: Lansoprazole	0.9	1.0	2.1	-0.7	1.0	1.5	0.4
Prospective memory result	1.4	1.8	2.1	1.1	-1.4	-1.4	1.4
Lung cancer (father)	1.8	2.1	4.7	1.3	-2.2	-1.2	-0.8
Illnesses of mother	2.2	2.7	3.2	-1.5	1.8	1.5	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.4	-0.7	0.9	1.6	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.7	0.1	0.3	-0.2	-1.3
Impedance of arm (left)	0.4	1.9	3.3	1.0	-1.5	-1.8	0.9
Arm fat mass (right)	0.1	0.4	0.8	0.2	-0.7	-0.2	0.9
Trunk predicted mass	0.6	3.2	6.1	-1.2	1.9	2.5	-1.3
Standing height	0.2	2.3	3.2	-0.7	1.6	1.8	-1.7
Length of working week for main job	0.3	0.4	1.1	1.1	-0.0	0.1	-0.5
Exposure to tobacco smoke at home	2.0	2.3	4.0	1.3	-1.9	-2.0	0.1
Breastfed as a baby	2.8	3.4	5.9	1.9	-1.7	-2.4	1.1
Tense / ‘highly strung’	0.9	1.5	3.5	1.9	-0.9	-1.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	0.1	0.3	-0.3	-0.9
Hair/balding pattern: Pattern 4	0.5	1.2	1.6	1.2	-1.3	-1.2	0.5
Birth weight of first child	1.0	1.9	2.4	1.4	-1.5	-1.4	1.2
Peak expiratory flow (PEF)	0.6	1.5	3.2	-0.7	1.0	1.8	-1.1
Pulse wave reflection index	0.2	0.3	0.7	0.5	-0.1	-0.4	-0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-0.7	-0.0	-0.2	-1.1
Loud music exposure frequency	0.9	1.0	1.6	1.3	-1.0	-1.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	-0.0	1.1	0.7	-0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.3	-2.1	1.2	0.7	-0.2
Blood clot in the leg (DVT)	0.8	1.1	1.6	-0.0	1.3	1.0	-1.3
Medication: Paracetamol	0.8	1.3	2.1	-1.5	0.1	1.0	-1.4
Headache pain in last month	0.1	0.2	0.3	-0.4	-0.6	-0.5	-0.2
Medication for cholesterol, blood pressure or diabetes	3.2	5.3	9.6	3.1	-2.4	-2.4	0.5
Glaucoma (self-reported)	0.9	1.1	2.0	-0.1	1.4	1.4	-0.6
Gout (self-reported)	0.6	0.8	2.6	-1.6	0.7	0.0	0.5
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.7	1.7	-1.1	-1.3	1.4
Medication: Amlodipine	5.4	7.6	8.8	-2.5	2.8	3.0	-2.8
Medication: Ventolin 100micrograms inhaler	5.1	6.5	7.9	-2.5	2.8	2.7	-2.1
Birth weight	1.3	2.8	4.0	-0.8	1.8	2.0	-1.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.6	0.0	-0.1	0.1
High blood pressure (siblings)	1.7	2.5	3.5	1.2	-1.5	-1.9	1.7
Forced vital capacity (FVC), Best measure	0.6	2.1	4.4	-1.1	1.7	2.1	0.0
Body fat percentage	0.5	2.0	3.1	0.8	-1.8	-1.5	1.5
Leg fat percentage (right)	0.7	2.5	4.6	0.9	-2.1	-1.7	1.4
Arm fat-free mass (right)	0.4	1.9	3.8	-1.0	1.4	1.9	-0.9
Exposure to tobacco smoke outside home	0.5	0.7	1.6	-0.9	0.4	0.3	-1.3
Comparative body size at age 10	0.3	0.9	1.2	-1.1	0.9	0.7	1.0
Number of full brothers	0.5	0.7	2.3	-1.5	0.3	0.6	-0.1
Worry too long after embarrassment	3.1	5.2	6.6	2.4	-2.4	-2.6	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.8	0.9	0.9	0.0
Wheeze or whistling in the chest in last year	0.9	1.7	2.6	-1.1	1.4	1.6	-0.9
Number of children fathered	3.0	3.3	5.0	-0.6	1.8	2.2	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	-0.2	0.9	0.8	-0.6
Age at first live birth	0.1	0.2	0.4	-0.1	0.6	0.6	-0.1
Pulse wave peak to peak time	0.3	0.3	1.1	-0.0	-0.1	0.3	1.1
Health satisfaction	3.0	3.9	6.1	-2.5	2.2	2.1	-0.4
Shortness of breath walking on level ground	1.2	1.4	1.6	-0.8	1.3	1.3	-1.3
Qualifications: College or University degree	1.1	3.3	4.3	-1.8	2.1	1.6	-1.7
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.2	-0.3	-0.0	-0.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.2	0.5	-0.5	-1.5	-1.1
Emphysema/chronic bronchitis	0.5	0.5	1.4	1.2	-0.4	-0.4	-0.6
Medication for pain relief, constipation, heartburn	2.5	4.3	9.8	3.1	-1.5	-1.7	1.5
Neck or shoulder pain in last month	0.4	0.6	1.0	-1.0	0.2	0.5	-1.0
Medication: Blood pressure	4.2	7.5	11.5	-3.4	2.9	2.9	-1.4
Angina (self-reported)	0.2	0.2	0.3	-0.5	0.6	0.5	0.3
Migraine (self-reported)	1.2	1.5	4.1	-1.1	0.7	0.5	-2.0
Medication: Ibuprofen	0.5	0.6	1.6	-1.3	0.8	0.5	-0.2
Medication: Allopurinol	0.2	0.3	0.6	-0.8	0.1	-0.5	0.5
Medication: Omeprazole	0.3	0.3	1.1	-1.1	0.3	0.2	0.1
Medication: Seretide 50 evohaler	0.5	0.5	0.7	0.3	0.8	0.9	-0.7
Mean time to correctly identify matches	0.9	1.7	3.0	-1.5	1.7	1.3	0.4
Heart disease (mother)	1.1	1.4	1.9	1.4	-1.0	-1.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.6	-0.8	0.2	0.7	-1.6
Whole body fat mass	0.2	0.8	1.2	0.5	-1.1	-0.7	1.0
Leg fat mass (right)	0.2	0.9	1.9	0.3	-1.4	-0.8	1.1
Arm predicted mass (right)	0.3	1.4	2.8	-0.9	1.1	1.7	-0.8
Pulse rate, automated reading	0.2	0.6	1.0	-0.8	0.6	1.0	-0.8
Alcohol intake frequency.	0.3	0.7	1.6	-0.1	-1.3	-0.0	1.2
Comparative height size at age 10	0.7	4.1	6.9	-1.3	2.2	1.8	-2.6
Number of full sisters	0.4	0.4	1.3	0.1	-0.6	-0.3	-1.1
Suffer from ‘nerves’	0.2	0.3	0.4	-0.4	-0.6	-0.5	-0.6
Overall health rating	1.4	2.9	4.6	-2.1	1.6	2.1	-0.2
Chest pain or discomfort	0.1	0.2	0.3	-0.3	0.5	0.3	-0.4
Had major operations	1.7	2.0	3.4	-1.8	1.3	1.2	-1.3
Age at last live birth	0.3	0.5	0.7	-0.2	0.8	0.9	-0.7
Family relationship satisfaction	0.1	0.1	0.3	-0.2	0.2	-0.6	-0.1
Leg pain on walking	0.1	0.1	0.4	-0.1	0.2	0.3	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.2	0.4	0.8	0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	0.8	0.5	0.7	0.6
Medication: Aspirin	0.0	0.1	0.2	-0.2	-0.0	-0.4	0.0
Supplements: Vitamin C	1.9	2.2	4.1	-0.6	1.4	1.6	-2.0
Knee pain experienced in last month	1.9	3.0	4.4	-2.0	1.2	1.4	-2.1
Hypertension (Self-reported)	3.5	9.8	15.9	-4.0	3.3	3.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.0	-2.0	1.9	1.9	-0.6
Illnesses of father: Heart disease	0.5	0.6	0.9	0.8	-0.6	-0.9	1.0
Illnesses of siblings: Diabetes	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.1
Smoking status: Previous	0.5	0.8	1.3	-0.9	-0.9	-1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	6.9	-1.9	2.0	2.6	-1.3
Whole body fat-free mass	0.3	1.5	3.3	-0.7	1.3	1.8	-0.8
Leg fat-free mass (right)	0.1	0.6	1.6	-0.1	0.8	1.3	-0.4
Arm fat percentage (left)	0.3	1.3	2.0	0.7	-1.4	-1.0	1.3
Average weekly red wine intake	0.2	0.2	0.6	-0.2	0.4	0.3	0.8
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.3	-0.1	-0.4	-0.1
Mood swings	0.8	1.4	2.8	0.8	-1.5	-1.7	0.2
Loneliness, isolation	2.5	3.4	5.7	2.4	-2.0	-2.0	0.1
Long-standing illness, disability or infirmity	2.3	3.5	5.5	-2.3	1.8	2.3	-0.2
Ever had bowel cancer screening	0.3	0.3	0.7	-0.7	-0.1	0.2	-0.9
Diabetes diagnosed by doctor	0.7	1.1	2.9	0.8	-0.6	-0.6	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.1	0.3	0.6	-0.6
Friendships satisfaction	0.6	0.7	1.4	-0.8	0.8	0.5	-1.2
Qualifications: nursing, teaching	0.1	0.1	0.5	-0.0	-0.3	0.0	-0.7
Commuting to job workplace: Walk	0.6	0.7	1.9	-0.6	0.4	0.5	-1.4
Eye problems/disorders: Cataract	0.5	0.5	1.4	-0.0	0.6	0.6	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	6.1	2.5	-0.3	0.1	-1.5
Medication for cholesterol	0.1	0.2	0.5	-0.2	0.5	0.7	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	2.4	-1.6	1.2	1.4	-1.0
Back pain experienced in last month	0.2	0.3	0.9	-0.7	-0.2	-0.0	0.9
Mineral and other dietary supplements	0.2	0.3	0.6	-0.8	0.3	0.5	0.5
Breast cancer (self-reported)	0.1	0.1	0.3	-0.6	0.3	-0.1	0.3
Asthma (self-reported)	6.3	12.5	17.1	-3.7	3.7	4.1	-2.4
Osteoporosis (self-reported)	0.2	0.2	0.9	0.0	-0.1	-0.9	0.1
Osteoarthritis (self-reported)	0.6	0.8	1.6	0.1	0.7	1.1	-1.3
Medication: Aspirin	0.0	0.0	0.1	-0.1	0.4	0.0	-0.1
Medication: Gliclazide	1.0	1.2	2.4	-0.9	1.0	0.5	-1.6
Illnesses of father: None of the above (group 1)	0.4	0.6	1.6	-0.6	0.2	0.3	-1.3
Smoking status: Current	0.2	0.3	0.6	0.6	-0.0	0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	6.5	-2.0	2.5	2.5	0.1
Whole body water mass	0.3	1.8	3.7	-0.8	1.4	1.9	-1.0
Leg predicted mass (right)	0.1	0.6	1.6	-0.1	0.8	1.3	-0.4
Arm fat mass (left)	0.1	0.4	0.8	0.4	-0.8	-0.3	0.9
Number of self-reported non-cancer illnesses	4.6	8.0	13.8	-3.7	2.7	3.1	-1.0
Average weekly champagne plus white wine intake	1.2	1.6	2.4	-1.6	1.4	0.9	-1.2
Miserableness	1.4	2.4	4.6	1.3	-2.1	-1.8	-0.2
Guilty feelings	1.9	2.8	5.2	1.6	-1.8	-2.3	-0.0
Wears glasses or contact lenses	0.7	0.8	3.1	-0.1	0.4	-0.0	1.8
Ever taken oral contraceptive pill	0.7	0.8	1.2	-0.6	-0.8	-1.0	-1.1
Hearing aid user	0.1	0.1	0.3	0.1	-0.4	0.1	-0.5
Mother’s age at death	0.3	0.3	0.8	0.1	-0.9	-0.6	-0.5
Financial situation satisfaction	1.2	1.5	4.1	-1.2	0.6	0.3	-2.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	0.2	-0.6	-0.1	-0.9
Commuting to job workplace: Public transport	0.2	0.3	0.9	0.9	-0.1	-0.6	-0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.2	0.5	0.3	0.6
Medication: Blood pressure	0.8	1.4	2.1	-1.5	1.4	1.0	-0.7
Pain type(s) experienced in last month: Hip pain	1.7	2.1	3.8	1.1	-2.0	-1.8	0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.9	1.2	-1.2	-1.4	0.1
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.2	-0.2	-0.4	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	0.5	-0.0	0.0
Medication: Paracetamol	0.5	0.8	2.4	-0.6	-0.1	0.5	-1.5
Medication: Lisinopril	0.1	0.2	0.3	0.5	-0.2	-0.4	0.6
Medication: Atorvastatin	5.4	6.7	9.2	-2.5	3.0	2.8	-2.0
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.5	-0.3	-0.2	0.7
Alcohol drinker status: Never	0.2	0.2	0.4	0.6	-0.3	0.1	0.5
Ever smoked	0.9	1.6	2.7	0.7	-1.5	-1.7	-0.8
Basal metabolic rate	0.2	1.1	2.6	-0.6	1.0	1.6	-0.6
Leg fat percentage (left)	0.7	2.4	3.5	1.0	-1.9	-1.5	1.6
Arm fat-free mass (left)	0.3	1.6	3.3	-0.8	1.2	1.8	-0.9
Number of operations (self-reported)	0.6	0.9	1.7	-0.9	0.8	1.3	-0.6
Average weekly beer plus cider intake	0.4	0.6	1.1	0.2	1.0	1.1	0.5
Irritability	0.3	0.5	1.8	1.4	-0.2	-0.4	-0.1
Risk taking	0.4	0.6	0.8	0.9	-0.7	-0.5	-0.9
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.8	0.7	-1.3	-1.4	2.2
Fractured/broken bones in last 5 years	1.5	2.0	6.2	-2.5	0.8	0.9	-0.4
Age started oral contraceptive pill	0.4	0.5	0.8	-0.4	0.4	0.9	-0.9
Diastolic blood pressure, automated reading	0.5	1.5	4.1	-2.0	1.0	0.9	-0.4
Ever depressed for a whole week	0.1	0.2	0.6	-0.1	0.2	0.0	-0.8
Unable to work because of sickness or disability	0.3	0.4	1.0	-1.0	-0.4	-0.3	0.7
Commuting to job workplace: Cycle	1.8	2.1	3.0	1.6	-1.7	-1.7	-0.2
Myopia	2.0	2.9	4.0	-2.0	2.0	2.0	0.0
Vascular/heart problems diagnosed by doctor	2.7	7.3	13.1	3.6	-2.9	-2.7	0.9
Cholesterol lowering medication	0.6	0.9	1.8	1.3	-0.0	-0.0	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.5	-0.7	0.1	-0.2	0.1
Pain experienced in last month	0.9	1.5	2.8	1.5	-0.6	-0.9	1.7
Supplements: Calcium	1.5	1.6	3.1	-1.2	1.0	1.1	-1.8
Basal cell carcinoma (self-reported)	1.7	2.0	3.3	-1.8	1.5	0.9	-1.2
Heart attack/myocardial infarction (self-reported)	1.9	2.4	3.6	-1.5	1.9	1.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.4	0.1	0.9	0.7	-1.2
Heart disease (siblings)	1.5	1.8	3.3	1.8	-0.7	-1.3	-1.3
Alcohol drinker status: Previous	0.5	0.5	1.4	0.1	-1.2	-0.8	0.3
Pack years of smoking	0.2	0.3	0.5	0.7	0.5	0.3	-0.5
Impedance of whole body	0.2	1.0	2.0	0.5	-1.1	-1.4	0.9
Leg fat mass (left)	0.1	0.6	1.0	0.3	-1.0	-0.5	1.0
Arm predicted mass (left)	0.3	1.3	3.0	-0.8	1.2	1.7	-0.6