Hub : Genes

SMARCC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0198 0.0116 0.00940 0.010 0.007 0.006 NA 0.004 0.0033 0.0140 0.01900 NA 0.0380
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0457 0.0257 0.00630 0.000 0.004 0.011 NA 0.007 0.2900 0.0920 0.01700 NA 0.0450
3 TCGA Brain Lower Grade Glioma 0.0492 0.0244 0.00047 0.027 0.023 0.024 NA 0.024 0.0004 0.0012 0.00083 NA 0.0009

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.7 1.1 -0.2 -1.0 1.0
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 -0.4 -0.2 0.1
Depressed Affect (Nagel 2018) 0.3 0.7 0.9 0.8 -0.9 0.7
Depression (Nagel 2018) 0.4 0.7 1.2 -0.1 -1.1 0.9
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.0 -1.0 0.2 0.4
Neuroticism (Nagel 2018) 0.1 0.1 0.3 -0.3 0.0 -0.5
Schizophrenia (2018) 0.1 0.3 0.5 -0.4 0.5 -0.7
Schizophrenia vs Biploar Disorder 1.3 1.7 5.0 0.0 0.0 -2.2
Worry (Nagel 2018) 0.1 0.1 0.3 -0.1 0.5 -0.2
Alzheimer’s Disease (in mother) 0.4 0.5 1.4 0.3 1.2 -0.0
Alzheimer’s Disease (in father) 0.5 0.6 0.7 0.8 -0.7 0.7
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 0.8 0.5 0.4
Crohns Disease (2017) 1.9 4.3 6.9 0.5 -2.6 2.4
Irritable Bowel Disease (IBD) 1.4 3.3 7.6 -0.6 -2.8 1.4
Ulcerative Colitis (UC) 0.8 1.4 3.0 -1.0 -1.7 0.5
Major Depression (MDD) 0.2 0.3 0.6 -0.5 -0.7 -0.4
Reaction Time 4.0 7.5 12.4 -3.5 -0.8 -3.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.1 0.5 1.0 0.8
Breast Cancer 1.2 2.9 4.9 0.6 -1.8 2.2
Ovarian Cancer 0.4 0.5 0.9 -0.9 0.3 -0.8
Prostate Cancer 0.6 0.8 2.2 0.0 1.5 -0.4
Age at First Birth 5.7 8.2 14.4 -3.8 0.7 -3.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.3 3.1 5.4 1.0 -2.3 1.7
Coronary Artery Disease (CAD) 1.5 1.8 3.1 -1.1 0.9 -1.8
Crohns Disease (2012) 0.8 1.3 2.5 -0.0 -1.6 1.1
Mean Putamen Volume 0.4 0.4 0.7 -0.4 -0.8 0.6
Fasting Glucose 1.1 1.3 3.1 0.7 1.8 -0.5
HbA1C 1.1 1.3 2.2 -1.2 0.4 -1.5
HDL Cholesterol 1.4 2.3 3.9 2.0 0.7 1.6
LDL Cholesterol 0.3 0.4 0.7 -0.3 -0.8 0.7
Lupus 0.5 0.7 1.9 -0.1 -1.4 0.4
Neuroticism (2016) 0.5 0.7 1.0 1.0 -0.4 1.0
Primary Biliary Cirrhosis 0.9 1.2 2.6 -0.4 -1.6 1.0
Rheumatoid Arthritis 0.2 0.3 0.5 -0.5 -0.7 -0.3
Schizophrenia (2014) 0.5 1.1 1.8 -1.4 0.1 -1.2
Triglycerides 0.7 1.2 2.6 -1.0 0.2 -1.6
Type 2 Diabetes (T2D) (2012) 3.6 4.2 8.1 -2.1 0.5 -2.8
Ulcerative Colitis 1.2 1.7 2.8 -1.7 -1.5 -0.0
Blood Eosinophil Count 0.5 4.2 7.4 -2.7 -0.8 -2.1
Blood Platelet Count 0.6 7.3 10.6 2.5 -2.3 3.3
Blood Red Count 0.6 5.6 8.1 -1.9 2.2 -2.9
Blood White Count 7.0 51.7 79.6 -8.6 -1.2 -8.9
Heel T-Score 2.9 23.1 38.7 -5.4 1.2 -6.2
BMI 1.3 7.4 9.8 3.0 -1.9 3.1
Height 0.7 12.8 25.3 -3.0 2.0 -5.0
Waist Hip Ratio (WHR) 3.6 16.2 25.0 -4.8 -0.5 -5.0
Systolic Blood Pressure 1.7 8.5 12.2 -1.9 3.5 -3.1
Smoking Status 5.3 12.6 16.8 2.2 -4.0 4.1
Allergy or Eczema 1.6 4.2 8.6 2.0 0.1 2.9
Cardiovascular Disease 1.4 4.8 6.3 -1.3 2.5 -2.5
Hypothyroidism (self reported) 0.4 1.0 2.7 -0.1 1.6 -0.5
Respiratory disease 1.9 4.2 5.3 2.2 -1.5 2.3
Type 2 Diabetes (T2D) (2018) 1.1 2.0 4.3 -1.3 0.4 -2.1
Lung FEV1/FVC ratio 1.2 6.2 11.0 -3.3 -1.1 -2.5
Lung FVC 0.7 3.4 8.0 -2.8 -0.0 -1.5
Neuroticism 0.2 0.5 1.1 0.6 1.1 0.1
Chronotype (morning person) 1.0 2.3 3.5 -1.9 -0.2 -1.8
Hair Pigment 0.1 3.4 6.6 2.6 0.3 1.9
Tanning 0.0 0.6 1.1 -0.3 -1.1 0.7
Hand grip strength (left) 0.0 0.1 0.1 0.0 0.2 -0.4
Number of treatments/medications taken 1.1 2.0 5.3 0.7 2.3 -0.4
Average weekly spirits intake 3.1 3.8 9.0 3.0 0.2 1.6
Sensitivity / hurt feelings 0.0 0.1 0.1 0.2 -0.2 0.3
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.4 -0.6 0.3 -0.5
Hearing difficulty/problems: Yes 1.2 1.9 2.9 -1.6 -1.7 -0.5
Relative age of first facial hair 0.8 1.6 4.5 -0.1 2.1 -0.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.7 0.2 1.6 -0.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.8 -0.5 0.7 -0.9
Ever had hysterectomy (womb removed) 3.0 3.4 5.6 2.1 2.4 0.4
Systolic blood pressure, automated reading 0.7 1.9 5.3 0.3 2.3 -0.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.0 0.0 -0.1 -1.0
Angina 0.5 0.6 1.5 -0.5 -1.2 -0.2
Medication for hormone replacement therapy 0.5 0.5 0.8 -0.5 0.8 -0.9
Vitamin and mineral supplements 7.9 10.7 20.1 -3.3 1.2 -4.5
Supplements: Zinc 0.7 0.7 1.4 0.9 1.2 0.1
Medication: Co-codamol 0.3 0.3 0.8 -0.9 -0.0 -0.4
Medication: Metformin 2.2 3.2 6.0 -1.6 1.0 -2.5
Diabetes (father) 1.8 2.2 4.8 -1.3 -2.2 0.0
Diabetes (mother) 2.3 2.9 4.8 -1.6 1.2 -2.2
Severe depression (siblings) 0.2 0.2 0.4 0.2 0.3 0.6
Pack years adult smoking proportion 1.3 2.0 5.2 -0.1 1.0 -2.3
Impedance of leg (right) 1.4 6.9 12.1 -1.7 2.4 -3.5
Leg fat-free mass (left) 0.1 0.3 0.5 0.7 -0.6 0.3
Trunk fat percentage 0.4 1.5 3.9 2.0 -0.4 0.6
Hand grip strength (right) 0.3 0.7 1.7 -0.2 0.6 -1.3
Townsend deprivation index at recruitment 1.8 2.5 4.6 0.9 -2.2 1.4
Current tobacco smoking 2.1 3.5 7.5 0.7 -2.7 1.6
Average weekly fortified wine intake 2.8 3.3 5.8 2.4 0.0 2.0
Maternal smoking around birth 0.5 0.7 1.3 -0.6 -0.8 -1.1
Fed-up feelings 0.7 1.3 3.2 1.8 -0.3 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 1.7 0.3 -1.2 1.3
Relative age voice broke 0.8 1.3 3.5 0.1 1.9 -0.5
Taking other prescription medications 0.3 0.5 1.0 -1.0 0.4 -0.6
Age when periods started (menarche) 1.7 4.2 8.8 1.9 3.0 0.4
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 5.5 0.3 2.3 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 8.2 -2.9 -0.4 -2.3
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 0.5 0.5 -0.3
Qualifications: CSEs or equivalent 1.5 2.0 3.6 -1.9 -1.4 -0.7
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.5 0.0 -0.1
High blood pressure 0.6 1.6 4.4 0.4 2.1 -0.4
Hayfever, allergic rhinitis or eczema 1.6 3.5 6.2 2.0 0.4 2.5
Multivitamins +/- minerals 3.7 4.7 9.1 1.8 -1.4 3.0
Stomach or abdominal pain in last month 0.6 0.7 2.0 0.0 -1.4 0.3
Supplements: Glucosamine 0.7 0.8 2.1 0.5 -0.5 1.4
Diverticular disease/diverticulitis (self-reported) 3.3 3.9 7.2 -1.4 1.6 -2.7
Medication: Atenolol 0.5 0.6 1.3 0.2 1.1 -0.7
Medication: Levothyroxine sodium 0.3 0.5 1.0 0.3 -0.6 1.0
Sitting height 0.7 4.6 6.8 -0.6 2.6 -2.6
Chronic bronchitis/emphysema (father) 0.2 0.3 0.7 0.2 0.1 -0.8
High blood pressure (mother) 0.6 0.9 1.7 -0.9 -1.3 0.3
Body mass index (BMI) 1.3 5.4 6.6 2.3 -2.1 2.6
Impedance of leg (left) 1.7 8.1 13.8 -2.2 2.4 -3.7
Leg predicted mass (left) 0.0 0.3 0.5 0.7 -0.4 0.2
Trunk fat mass 0.2 1.0 2.7 1.6 -0.4 0.4
Waist circumference 0.1 0.3 0.9 0.2 -1.0 0.0
Number of incorrect matches in round 0.6 1.0 1.7 1.0 1.3 0.5
Past tobacco smoking 2.7 5.0 8.1 -1.7 2.1 -2.8
Alcohol usually taken with meals 0.2 0.3 0.6 -0.7 0.8 -0.1
Nervous feelings 0.2 0.4 1.1 0.4 1.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.9 -1.1 0.0 -1.4
Hearing difficulty/problems with background noise 0.6 1.0 2.0 -0.5 -1.4 0.8
Hair/balding pattern: Pattern 2 0.1 0.1 0.4 -0.1 -0.6 -0.1
Had menopause 0.3 0.3 0.4 0.6 0.4 0.7
Had other major operations 0.6 0.7 1.1 1.1 0.0 1.0
Forced vital capacity (FVC) 1.2 4.7 6.6 -2.6 1.0 -2.5
Heel bone mineral density (BMD) T-score, automated (right) 3.5 7.9 12.4 -3.5 0.4 -3.4
Ever unenthusiastic/disinterested for a whole week 3.2 3.9 6.9 0.8 -2.0 2.6
Qualifications: None of the above 2.1 4.6 8.8 3.0 -0.3 2.2
Financial difficulties in last 2 years 0.5 0.6 1.5 0.2 -1.2 0.6
Mouth/teeth dental problems 2.0 3.1 4.3 -1.4 1.7 -2.1
Heart attack 1.0 1.2 1.9 -1.4 -0.3 -1.3
Allergy 2.3 5.3 9.3 -2.5 0.8 -3.1
Pain all over the body in last month 0.7 0.7 1.0 0.7 -0.8 1.0
Diabetes (self-reported) 0.6 0.9 2.0 -0.8 0.4 -1.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 0.8 0.7 0.9 0.7
Medication: Ramipril 0.4 0.5 1.0 0.1 -0.7 1.0
Medication: Simvastatin 0.3 0.4 0.8 -0.6 0.5 -0.9
Fluid intelligence score 0.2 0.5 0.9 -0.6 0.9 -0.5
Illnesses of siblings 0.2 0.3 0.8 0.9 0.3 -0.1
Neuroticism score 0.0 0.1 0.2 0.4 0.2 0.1
Weight 0.1 0.5 0.7 0.8 -0.8 0.3
Impedance of arm (right) 0.3 1.3 2.7 -0.7 0.9 -1.6
Arm fat percentage (right) 1.2 4.7 5.7 2.4 -1.9 2.2
Trunk fat-free mass 0.0 0.1 0.3 -0.3 0.0 -0.5
Hip circumference 0.9 4.0 6.9 2.6 -0.5 2.2
Time employed in main current job 1.6 1.8 3.2 0.1 -1.8 1.5
Alcohol intake versus 10 years previously 0.7 1.1 1.8 0.6 -1.4 1.0
Father’s age at death 0.4 0.5 1.4 -1.2 -0.3 -0.1
Worrier / anxious feelings 0.8 1.6 3.6 -1.9 -0.0 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.6 -0.7 -0.8 -0.4
Falls in the last year 0.9 1.3 2.3 0.3 -1.5 1.1
Hair/balding pattern: Pattern 3 0.3 0.4 0.7 -0.8 -0.7 0.1
Number of live births 0.1 0.1 0.2 0.4 -0.1 -0.4
Forced expiratory volume in 1-second (FEV1) 1.7 5.8 10.0 -3.2 0.4 -2.7
Pulse rate 2.3 3.9 8.7 -1.5 0.9 -2.9
Happiness 1.4 1.8 2.7 -1.6 -1.6 -0.2
Noisy workplace 0.3 0.3 0.7 0.1 0.8 -0.5
Qualifications: A levels/AS levels or equivalent 0.9 2.0 5.2 -2.3 -0.8 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 0.1 -0.8 -0.0
Mouth/teeth dental problems: Dentures 0.6 1.0 1.4 1.2 -0.9 1.0
Asthma 1.9 3.8 5.8 1.9 -1.4 2.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.3 0.5 -1.1 0.4
Medication: Cholesterol lowering 0.3 0.4 0.9 -0.3 1.0 -0.5
Depression (self-reported) 1.8 2.1 3.8 1.5 -0.5 2.0
Medication: Lansoprazole 6.1 7.0 10.7 -3.3 0.9 -3.1
Prospective memory result 0.0 0.0 0.1 0.3 -0.1 -0.1
Lung cancer (father) 0.5 0.6 0.9 0.3 0.9 -0.9
Illnesses of mother 0.3 0.4 0.7 0.8 -0.3 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 5.9 9.7 -3.1 0.2 -2.9
Pulse wave Arterial Stiffness index 2.2 2.5 5.6 0.6 2.4 -1.2
Impedance of arm (left) 0.4 1.8 3.8 -1.1 0.7 -1.9
Arm fat mass (right) 0.7 2.9 3.9 2.0 -1.5 1.6
Trunk predicted mass 0.0 0.3 0.5 -0.5 0.1 -0.7
Standing height 1.3 13.0 23.0 -2.9 2.7 -4.8
Length of working week for main job 0.4 0.5 0.9 0.9 0.8 0.1
Exposure to tobacco smoke at home 0.5 0.5 0.8 0.5 0.8 0.9
Breastfed as a baby 0.2 0.3 0.4 0.3 0.6 0.6
Tense / ‘highly strung’ 0.6 1.0 1.8 0.1 1.4 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.1 3.4 1.6 -0.4 1.9
Hair/balding pattern: Pattern 4 1.1 2.7 5.6 2.4 1.0 1.1
Birth weight of first child 1.4 2.5 3.6 1.1 -1.7 1.9
Peak expiratory flow (PEF) 0.4 0.9 2.3 -1.5 -0.6 -0.3
Pulse wave reflection index 3.0 3.7 6.3 2.2 -0.1 2.5
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.2 -0.1 -1.5 0.9
Loud music exposure frequency 1.3 1.4 2.3 -1.3 -1.5 -0.4
Qualifications: O levels/GCSEs or equivalent 4.6 7.4 17.1 -4.1 -1.6 -1.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 0.7 -0.8 -0.8 0.7
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.9 -0.5 -0.3
Medication: Paracetamol 0.6 1.0 1.3 1.2 1.2 -0.4
Headache pain in last month 0.3 0.6 0.9 -0.9 -0.7 -0.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.1 0.1 -2.0 0.8
Glaucoma (self-reported) 1.9 2.3 4.2 -2.1 0.3 -1.6
Gout (self-reported) 0.6 0.8 1.0 -0.8 0.8 -1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.5 -0.4 1.2 -0.5
Medication: Amlodipine 1.1 1.5 3.6 1.0 1.9 0.0
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.3 0.5 0.6 0.5
Birth weight 0.9 2.0 3.4 1.8 0.9 1.4
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.5 -0.5 0.1 -1.2
High blood pressure (siblings) 0.1 0.1 0.1 -0.4 0.3 -0.2
Forced vital capacity (FVC), Best measure 1.8 6.7 10.2 -3.2 0.7 -3.1
Body fat percentage 0.5 1.8 4.1 2.0 -0.7 1.0
Leg fat percentage (right) 0.6 2.1 4.5 2.1 -0.5 1.2
Arm fat-free mass (right) 0.1 0.3 0.7 -0.2 0.1 -0.9
Exposure to tobacco smoke outside home 0.3 0.5 1.2 0.1 1.1 -0.4
Comparative body size at age 10 6.0 16.6 24.1 2.5 -4.4 4.9
Number of full brothers 0.4 0.4 1.1 0.4 -1.0 0.3
Worry too long after embarrassment 1.2 2.0 3.5 -1.9 -0.1 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 2.2 0.3 -1.5 1.3
Wheeze or whistling in the chest in last year 1.9 3.4 5.3 1.6 -1.5 2.3
Number of children fathered 0.1 0.1 0.2 0.2 -0.0 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.2 -0.6 -1.8 0.8
Age at first live birth 0.4 0.7 1.1 -1.1 0.4 -0.9
Pulse wave peak to peak time 1.7 2.0 4.5 -0.9 -2.1 0.8
Health satisfaction 0.6 0.8 1.9 1.4 -0.2 0.6
Shortness of breath walking on level ground 0.8 0.9 2.2 1.5 -0.6 0.6
Qualifications: College or University degree 4.9 15.5 32.9 -5.7 -0.8 -3.6
Eye problems/disorders: None of the above 0.3 0.3 0.6 0.4 -0.8 0.4
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.6 0.2 -1.6 1.0
Emphysema/chronic bronchitis 3.9 4.4 7.7 2.8 -1.2 2.0
Medication for pain relief, constipation, heartburn 0.2 0.4 1.1 -1.1 -0.2 0.1
Neck or shoulder pain in last month 0.2 0.3 0.7 -0.4 0.3 -0.8
Medication: Blood pressure 1.6 2.7 6.6 -0.5 2.6 -1.2
Angina (self-reported) 0.4 0.6 1.1 -0.7 -1.0 -0.4
Migraine (self-reported) 1.5 1.8 3.4 -1.4 -1.8 0.1
Medication: Ibuprofen 1.2 1.4 1.6 1.3 -1.2 1.1
Medication: Allopurinol 1.4 1.9 2.7 -0.8 1.6 -1.5
Medication: Omeprazole 4.6 5.5 7.7 1.5 -2.8 2.6
Medication: Seretide 50 evohaler 2.0 2.3 4.3 1.2 -1.0 2.1
Mean time to correctly identify matches 3.2 6.1 11.2 -3.3 -0.2 -2.7
Heart disease (mother) 0.4 0.4 0.5 -0.7 0.6 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.0 0.5 -1.0 0.9
Whole body fat mass 0.3 1.1 2.5 1.6 -0.6 0.7
Leg fat mass (right) 0.3 1.2 2.2 1.5 -0.9 0.8
Arm predicted mass (right) 0.1 0.4 1.0 -0.1 0.5 -1.0
Pulse rate, automated reading 3.7 12.0 18.1 -0.5 4.2 -4.2
Alcohol intake frequency. 0.4 0.8 1.7 0.3 0.9 -1.3
Comparative height size at age 10 0.4 2.2 4.8 -1.4 0.0 -2.2
Number of full sisters 2.5 3.0 7.0 -0.6 -2.6 1.3
Suffer from ‘nerves’ 0.6 1.0 1.6 1.3 0.7 0.9
Overall health rating 0.2 0.5 1.0 -0.4 0.5 -1.0
Chest pain or discomfort 0.0 0.0 0.1 -0.1 0.2 -0.2
Had major operations 0.1 0.1 0.4 -0.2 0.1 0.6
Age at last live birth 0.4 0.5 0.9 -0.8 0.1 -0.9
Family relationship satisfaction 0.5 0.6 1.5 -0.2 -1.2 0.6
Leg pain on walking 0.2 0.3 0.9 -0.1 -0.1 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.8 0.1 -1.3 0.4
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.4 1.2 0.8 0.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 1.1 0.1 0.4
Medication: Aspirin 0.7 1.0 1.4 -0.8 0.9 -1.2
Supplements: Vitamin C 0.1 0.1 0.2 0.2 0.5 0.2
Knee pain experienced in last month 0.5 0.8 1.8 -0.8 -1.3 -0.3
Hypertension (Self-reported) 0.5 1.5 4.1 0.2 2.0 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.5 -0.6 -1.2 0.5
Illnesses of father: Heart disease 0.3 0.4 0.9 0.0 -0.5 0.9
Illnesses of siblings: Diabetes 0.1 0.2 0.3 0.1 0.5 -0.4
Smoking status: Previous 1.6 2.3 4.3 1.3 -1.0 2.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 5.3 -1.3 0.8 -2.3
Whole body fat-free mass 0.0 0.0 0.1 0.1 -0.2 -0.3
Leg fat-free mass (right) 0.0 0.2 0.3 0.4 -0.6 0.2
Arm fat percentage (left) 1.0 4.0 5.2 2.3 -1.7 2.0
Average weekly red wine intake 0.1 0.1 0.3 -0.6 -0.2 0.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.8 -0.4 -0.9 0.7
Mood swings 0.5 1.0 2.4 -0.7 -1.5 -0.4
Loneliness, isolation 0.2 0.2 0.6 0.0 0.8 -0.4
Long-standing illness, disability or infirmity 0.3 0.5 0.8 0.1 0.9 -0.8
Ever had bowel cancer screening 0.3 0.3 0.8 -0.2 -0.9 0.3
Diabetes diagnosed by doctor 1.2 2.0 4.0 -1.4 0.3 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 1.7 1.2 -1.0 1.3
Friendships satisfaction 1.4 1.8 3.0 -1.5 -1.7 0.1
Qualifications: nursing, teaching 0.5 0.8 1.4 -0.4 -1.0 1.2
Commuting to job workplace: Walk 2.4 2.6 5.4 -0.8 -2.3 1.3
Eye problems/disorders: Cataract 1.3 1.5 4.1 0.6 2.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 3.1 5.0 8.1 1.7 -2.0 2.8
Medication for cholesterol 0.2 0.3 0.5 0.7 0.4 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.8 1.3 -0.3 0.8
Back pain experienced in last month 0.4 0.6 0.9 -0.2 -1.0 -0.9
Mineral and other dietary supplements 0.8 1.0 2.9 -0.2 0.3 -1.7
Breast cancer (self-reported) 0.4 0.5 0.9 0.9 0.8 -0.1
Asthma (self-reported) 2.0 4.0 5.8 2.3 -1.0 2.4
Osteoporosis (self-reported) 0.3 0.4 0.5 0.7 0.5 0.7
Osteoarthritis (self-reported) 1.0 1.3 2.1 -1.5 -1.3 -0.2
Medication: Aspirin 0.4 0.5 0.8 -0.4 0.8 -0.9
Medication: Gliclazide 0.7 0.8 1.4 -0.9 0.5 -1.2
Illnesses of father: None of the above (group 1) 0.2 0.3 0.6 -0.3 0.4 -0.8
Smoking status: Current 2.2 3.4 7.7 0.4 -2.8 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.9 -2.0 -0.7 -0.8
Whole body water mass 0.0 0.0 0.1 0.1 -0.2 -0.3
Leg predicted mass (right) 0.0 0.2 0.3 0.4 -0.5 0.2
Arm fat mass (left) 0.6 2.5 3.1 1.8 -1.5 1.4
Number of self-reported non-cancer illnesses 0.4 0.7 1.8 0.4 1.3 -0.1
Average weekly champagne plus white wine intake 0.3 0.4 0.8 -0.4 0.9 -0.4
Miserableness 0.4 0.8 2.3 1.5 0.0 0.2
Guilty feelings 0.1 0.2 0.5 0.3 -0.2 0.7
Wears glasses or contact lenses 1.2 1.3 3.5 0.7 1.9 -0.0
Ever taken oral contraceptive pill 1.2 1.3 3.3 0.1 1.8 -0.8
Hearing aid user 1.0 1.2 2.7 -1.6 -0.8 -0.5
Mother’s age at death 1.5 1.8 3.8 -0.5 2.0 -1.2
Financial situation satisfaction 1.0 1.3 1.4 -1.0 -1.1 -1.2
Tinnitus: Yes, now most or all of the time 1.3 1.6 3.3 -1.8 -1.0 -0.7
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.1 0.4 0.3
Eye problems/disorders: Glaucoma 2.0 2.4 3.4 -1.7 1.0 -1.8
Medication: Blood pressure 0.2 0.4 1.0 -0.1 -0.5 1.0
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.5 -0.8 -1.2 0.2
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.9 -0.2 -0.1 1.0
High cholesterol (Self-reported) 0.1 0.2 0.3 -0.5 -0.4 -0.5
Medication: Bendroflumethiazide 0.1 0.2 0.3 0.4 0.5 0.5
Medication: Paracetamol 1.0 1.6 3.0 1.7 1.3 -0.4
Medication: Lisinopril 0.9 1.2 2.7 -1.6 -0.3 -0.9
Medication: Atorvastatin 0.0 0.0 0.1 0.2 -0.1 0.2
Illnesses of father: High blood pressure 1.3 1.6 2.1 -1.1 1.5 -1.2
Alcohol drinker status: Never 0.5 0.6 1.1 -0.1 -0.8 -1.1
Ever smoked 3.7 6.6 10.0 2.5 -1.8 3.2
Basal metabolic rate 0.0 0.1 0.2 0.3 -0.4 -0.1
Leg fat percentage (left) 0.5 1.9 3.9 2.0 -0.6 1.2
Arm fat-free mass (left) 0.0 0.1 0.4 -0.0 -0.0 -0.6
Number of operations (self-reported) 0.1 0.1 0.2 -0.0 0.3 0.5
Average weekly beer plus cider intake 0.2 0.2 0.6 0.3 -0.8 0.3
Irritability 0.1 0.2 0.6 -0.8 -0.2 -0.3
Risk taking 1.9 2.8 6.7 -1.2 -2.6 0.4
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.1 0.4 -1.4 1.4
Fractured/broken bones in last 5 years 0.3 0.3 0.6 0.5 -0.3 0.8
Age started oral contraceptive pill 0.5 0.6 1.3 -0.1 1.1 -0.7
Diastolic blood pressure, automated reading 2.4 7.4 14.4 -0.7 3.8 -2.7
Ever depressed for a whole week 2.1 2.6 4.5 1.7 -0.6 2.1
Unable to work because of sickness or disability 0.6 0.8 1.1 0.9 -1.0 0.7
Commuting to job workplace: Cycle 0.5 0.6 0.8 -0.8 0.6 -0.9
Myopia 0.5 0.7 1.5 0.7 0.4 1.2
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.0 -0.0 -1.7 0.4
Cholesterol lowering medication 0.6 0.8 1.8 -0.8 -0.4 -1.3
Medication: Omeprazole (e.g. Zanprol) 3.1 3.8 7.3 0.8 -2.7 1.9
Pain experienced in last month 0.5 0.8 1.7 0.7 1.3 0.5
Supplements: Calcium 1.2 1.3 2.6 1.1 -0.1 1.6
Basal cell carcinoma (self-reported) 0.8 0.9 2.0 -0.6 -1.4 0.6
Heart attack/myocardial infarction (self-reported) 1.0 1.2 2.0 -1.4 -0.6 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.2 -1.1 -0.2 -0.6
Heart disease (siblings) 0.2 0.2 0.7 -0.1 0.2 0.8
Alcohol drinker status: Previous 2.8 3.2 5.4 2.3 1.9 0.8
Pack years of smoking 1.7 2.5 6.0 -0.4 1.2 -2.4
Impedance of whole body 1.1 5.6 10.8 -1.7 1.8 -3.3
Leg fat mass (left) 0.3 1.1 1.8 1.4 -0.9 0.8
Arm predicted mass (left) 0.0 0.1 0.3 -0.0 -0.2 -0.5