Hub : Genes

SMCO4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0779	0.0369	8.1e-03	0.009	NA	0.004	NA	0.007	6.2e-02	NA	1.4e-01	NA	8.5e-02
2	GTEx	Colon Transverse	0.2860	0.0640	1.2e-08	0.245	NA	0.183	NA	0.196	5.3e-12	NA	4.3e-09	NA	1.2e-09
3	GTEx	Esophagus Mucosa	0.3030	0.0640	5.4e-09	0.030	NA	0.115	NA	0.119	4.2e-03	NA	4.0e-08	NA	2.6e-08
4	GTEx	Pancreas	0.2080	0.0580	2.4e-05	0.046	NA	0.085	NA	0.044	5.0e-03	NA	1.9e-04	NA	6.0e-03
5	GTEx	Testis	0.1420	0.0570	4.5e-03	-0.002	NA	-0.005	NA	-0.006	4.0e-01	NA	5.9e-01	NA	9.4e-01
6	GTEx	Thyroid	0.1060	0.0490	5.2e-03	0.016	NA	-0.001	NA	-0.004	2.1e-02	NA	4.1e-01	NA	9.8e-01
7	GTEx	Whole Blood	0.1780	0.0530	3.1e-05	0.146	NA	0.122	NA	0.140	2.2e-13	NA	2.7e-11	NA	7.0e-13
8	METSIM	Adipose	0.0957	0.0279	8.3e-08	0.063	0.070	0.077	0.072	0.073	9.4e-10	1.2e-10	1.3e-11	6.5e-11	4.5e-11
9	ROSMAP	Brain Pre-frontal Cortex	0.0809	0.0261	2.0e-06	0.069	0.056	0.076	0.071	0.084	2.8e-09	1.1e-07	4.7e-10	2.0e-09	6.4e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.2	0.3	1.1	0.3	-0.4	0.8	0.3	0.9	-0.4	-0.1	-1.0	0.0
Bipolar Disorder or Schizophrenia	0.5	1.3	3.0	-0.2	-1.5	1.2	-0.6	1.4	-1.2	-0.3	-1.7	-1.1
Depressed Affect (Nagel 2018)	0.5	1.0	2.4	0.6	1.1	1.3	1.4	0.3	1.5	-0.6	-0.2	0.9
Depression (Nagel 2018)	1.4	2.1	3.8	0.3	1.6	1.8	1.8	0.3	1.9	-1.2	-2.0	1.2
Intelligence (Savage-Jansen 2018)	0.7	2.0	6.3	2.5	1.6	-1.7	1.4	0.0	0.6	-0.1	0.8	1.9
Neuroticism (Nagel 2018)	0.7	1.7	4.3	-0.0	-1.0	2.0	0.2	0.9	-0.4	-2.1	-1.9	-1.0
Schizophrenia (2018)	0.6	1.3	2.4	-0.4	-1.6	0.9	-1.0	1.0	-1.3	-0.4	-1.4	-1.4
Schizophrenia vs Biploar Disorder	0.6	0.7	3.3	0.5	-0.1	-0.5	0.6	-0.6	0.5	1.4	1.8	0.1
Worry (Nagel 2018)	1.6	3.4	7.6	-1.0	-2.7	0.7	-1.4	0.3	-2.2	-1.9	-1.9	-2.8
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	0.1	0.7	-1.2	-1.1	0.9	1.0	0.4	0.7	1.3
Alzheimer’s Disease (in father)	0.3	0.4	1.3	-0.6	-0.3	-0.3	-0.9	0.2	-0.4	0.7	1.1	0.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	-0.3	0.1	-1.1	-1.1	0.4	0.2	0.5	1.1	0.7
Crohns Disease (2017)	0.7	1.5	4.9	-1.0	-0.4	0.3	-1.4	-0.9	1.2	1.9	2.2	-0.3
Irritable Bowel Disease (IBD)	0.5	1.3	4.4	-0.3	-0.5	-0.3	-0.8	-1.9	0.5	1.6	2.1	-0.0
Ulcerative Colitis (UC)	0.6	1.1	4.4	0.1	-1.1	-0.8	-0.5	-2.1	-0.8	0.9	1.4	-0.4
Major Depression (MDD)	0.9	1.1	4.0	-1.5	-0.3	1.5	-0.7	2.0	-0.1	0.6	0.1	-0.5
Reaction Time	0.5	1.0	2.6	-0.8	-0.9	-0.4	-1.1	-0.5	-0.5	1.0	1.6	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.8	1.5	1.3	0.2	1.0	0.6	0.7	-0.1	-0.4	1.7
Breast Cancer	0.2	0.4	1.0	1.0	0.1	-0.6	0.8	-0.6	0.1	0.6	0.7	0.6
Ovarian Cancer	1.2	1.6	3.4	-0.3	1.8	-1.4	0.7	-1.3	1.4	0.6	1.8	1.0
Prostate Cancer	0.3	0.4	1.9	-0.7	0.1	1.4	-0.3	-0.8	-0.0	-0.1	-0.8	-0.6
Age at First Birth	0.9	1.4	3.6	1.1	-0.5	-1.8	-0.1	-1.1	-1.2	-1.9	-1.2	-0.3
Bipolar Disorder (2011)	0.6	0.6	2.8	0.7	-0.2	0.2	0.5	-0.9	-0.1	-1.0	-1.7	-0.2
Body Mass Index (BMI) (2010)	1.3	1.8	3.2	1.5	1.4	-1.8	0.6	-1.4	1.6	0.7	1.5	1.1
Coronary Artery Disease (CAD)	1.1	1.3	2.8	1.1	1.7	-1.3	0.4	1.0	1.7	-0.2	0.3	1.4
Crohns Disease (2012)	0.3	0.4	1.4	-0.0	0.3	0.6	-0.5	-0.8	1.2	1.0	0.4	0.3
Mean Putamen Volume	0.4	0.5	2.5	0.7	0.5	-1.6	0.8	-0.2	0.2	-0.5	-0.1	0.3
Fasting Glucose	4.1	4.9	8.8	2.5	2.8	-1.6	2.6	-1.5	3.0	0.6	0.9	2.8
HbA1C	1.3	1.4	4.0	0.5	0.8	-2.0	0.7	-1.9	0.1	0.4	1.6	0.9
HDL Cholesterol	0.3	0.5	1.8	0.7	0.3	-0.0	0.6	-1.4	0.0	0.9	0.7	0.5
LDL Cholesterol	0.8	1.3	3.8	0.7	0.7	-0.1	0.4	-1.9	0.8	1.3	1.8	1.0
Lupus	0.7	1.0	2.3	-1.0	-1.5	-0.8	-1.1	1.0	-1.1	-0.4	-0.3	-1.2
Neuroticism (2016)	0.6	0.9	5.2	0.3	-0.2	2.3	0.1	1.4	-0.2	0.5	-0.7	0.1
Primary Biliary Cirrhosis	0.4	0.6	3.3	0.5	-0.6	-1.8	-0.3	-0.8	-0.8	0.3	-0.4	-0.3
Rheumatoid Arthritis	2.1	2.9	7.8	-1.2	-1.7	0.8	-1.0	1.2	-2.1	-2.8	-2.1	-1.6
Schizophrenia (2014)	0.3	0.7	2.0	-0.4	-1.4	0.1	-0.8	0.7	-1.2	0.1	-0.6	-1.2
Triglycerides	0.3	0.5	1.7	0.5	-0.0	-1.2	0.7	-1.3	-0.4	-0.7	-0.6	-0.1
Type 2 Diabetes (T2D) (2012)	1.5	1.7	7.7	1.4	0.4	-2.8	1.0	-1.2	0.2	-0.7	-1.5	0.9
Ulcerative Colitis	1.0	1.4	5.1	0.6	-1.1	-1.6	-0.5	-2.3	-1.4	0.4	1.1	-0.3
Blood Eosinophil Count	0.1	0.6	1.5	0.7	0.5	-1.2	1.2	-0.6	-0.0	0.4	0.8	0.5
Blood Platelet Count	0.1	0.7	2.2	-0.9	-1.1	-0.2	0.0	-0.4	-0.8	-1.0	-0.1	-1.5
Blood Red Count	0.1	0.5	2.0	0.8	0.1	0.5	0.0	-0.5	-0.8	1.4	-0.8	0.3
Blood White Count	0.3	2.0	7.0	1.3	1.3	1.6	2.6	0.8	0.8	-0.7	-1.5	1.1
Heel T-Score	0.1	1.1	3.8	0.6	0.2	-2.0	-0.2	-1.2	0.7	1.0	1.7	0.2
BMI	2.7	15.4	32.4	3.8	5.7	-2.3	4.5	-1.2	5.5	1.8	1.6	5.4
Height	0.0	0.7	1.7	1.1	0.9	-1.0	0.0	0.3	0.8	0.8	0.3	1.3
Waist Hip Ratio (WHR)	0.4	1.7	5.7	0.7	-0.1	1.6	1.9	2.4	-0.1	-1.1	-1.1	-0.2
Systolic Blood Pressure	0.7	3.4	9.0	-1.3	-2.8	-1.2	-1.6	-0.3	-3.0	-0.7	0.7	-2.7
Smoking Status	1.1	2.7	6.1	-2.5	-0.1	1.6	-1.4	0.7	0.7	2.4	2.4	-0.6
Allergy or Eczema	0.3	0.8	4.1	0.2	-0.8	-2.0	-0.1	-1.1	-0.5	-0.4	0.3	-0.7
Cardiovascular Disease	0.6	2.0	4.3	1.6	1.8	-0.9	2.1	-1.0	1.7	-0.9	-0.6	1.3
Hypothyroidism (self reported)	0.2	0.4	2.1	-0.4	0.2	0.5	0.6	1.4	-0.4	-0.3	-0.5	-0.3
Respiratory disease	0.2	0.5	1.2	-1.1	-0.7	0.4	0.2	0.6	-0.3	-0.8	-0.4	-1.1
Type 2 Diabetes (T2D) (2018)	4.4	8.3	21.6	4.0	3.4	-1.2	4.6	-1.4	3.1	-0.2	-1.2	3.4
Lung FEV1/FVC ratio	0.9	4.3	7.7	2.6	2.2	-1.5	1.9	-1.6	2.1	2.1	1.5	2.8
Lung FVC	0.3	1.4	5.2	0.0	0.1	-1.3	-1.5	-0.9	-0.1	1.7	2.3	0.1
Neuroticism	0.3	0.7	2.1	0.6	-0.2	1.2	0.6	1.0	-0.3	-1.4	-1.1	-0.1
Chronotype (morning person)	1.4	3.2	9.3	2.4	1.8	-1.5	0.3	-2.0	1.5	-0.3	-3.0	1.4
Hair Pigment	0.0	0.3	0.5	0.1	-0.7	0.7	-0.0	-0.6	-0.5	0.6	0.3	-0.6
Tanning	0.1	0.8	2.8	-0.4	-1.1	0.9	-0.7	0.1	-0.9	-1.7	-0.7	-0.9
Hand grip strength (left)	0.2	0.6	2.2	0.5	-0.6	-1.5	0.4	-0.5	-1.0	-1.0	-0.5	-0.6
Number of treatments/medications taken	0.1	0.2	0.6	0.2	-0.2	-0.2	0.1	0.2	0.4	0.5	0.8	-0.5
Average weekly spirits intake	0.8	1.0	3.9	-2.0	-0.6	1.4	-0.3	0.3	-0.1	-0.4	0.6	-1.5
Sensitivity / hurt feelings	0.6	1.0	3.2	1.8	-0.4	1.2	1.3	0.8	-0.6	-0.6	-1.0	0.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.6	-0.0	1.3	1.6	0.6	0.6	1.5	-0.4	-0.6	1.1
Hearing difficulty/problems: Yes	0.6	1.0	4.3	0.2	-0.2	-1.0	-0.3	-1.1	-0.5	1.3	2.1	-0.4
Relative age of first facial hair	1.0	2.0	3.9	-0.6	-1.4	1.6	0.4	0.1	-1.9	-1.9	-2.0	-1.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.8	-0.2	1.2	0.4	0.1	-0.2	1.7	0.4	0.5	0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.6	0.8	0.1	-1.0	0.1	-1.3	0.1	0.4	1.1	-0.1
Ever had hysterectomy (womb removed)	0.4	0.4	1.4	0.4	1.0	-0.1	0.1	-0.8	1.2	-0.5	-0.3	0.3
Systolic blood pressure, automated reading	0.7	1.9	3.5	-0.2	-1.9	-1.4	-1.1	-1.4	-1.9	0.5	1.4	-1.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.4	-0.0	0.4	1.2	0.2	-0.5	0.2	-0.3	-0.8	0.3
Angina	0.4	0.5	2.3	0.8	0.5	-0.5	1.5	-0.5	0.9	-0.3	0.2	0.2
Medication for hormone replacement therapy	0.2	0.3	0.9	-0.3	-0.4	-0.5	0.1	-0.9	-0.3	-0.4	-0.5	-0.6
Vitamin and mineral supplements	0.6	0.8	3.2	0.9	-0.1	-0.8	1.2	-1.8	-0.2	0.7	-0.1	0.4
Supplements: Zinc	0.6	0.7	2.5	-0.1	-0.2	1.6	-0.1	0.8	0.4	-0.8	-1.4	-0.3
Medication: Co-codamol	0.5	0.6	1.8	0.7	1.0	0.8	0.8	0.5	1.4	0.1	0.2	0.7
Medication: Metformin	2.3	3.3	8.7	2.3	2.3	-0.5	2.9	-1.4	2.0	-0.5	-0.7	1.9
Diabetes (father)	2.9	3.6	8.0	1.9	2.5	-1.6	2.0	-0.2	2.3	1.3	1.1	2.8
Diabetes (mother)	1.5	1.9	5.1	0.7	1.4	-0.6	2.3	-1.2	1.8	1.1	1.7	1.0
Severe depression (siblings)	0.7	0.7	3.3	-0.8	-0.5	1.8	0.3	1.0	-0.2	-0.5	-1.1	-0.4
Pack years adult smoking proportion	0.9	1.3	6.1	0.3	0.5	1.2	0.8	1.3	0.4	-1.2	-2.5	0.6
Impedance of leg (right)	0.8	3.8	9.1	-1.8	-3.0	1.0	-1.8	1.1	-2.5	-1.0	-0.7	-2.9
Leg fat-free mass (left)	0.7	3.9	9.2	1.9	3.0	-1.4	2.9	-0.4	2.1	-0.1	-0.5	2.8
Trunk fat percentage	1.1	4.3	7.8	2.1	2.8	-1.7	2.6	-0.2	2.7	1.2	0.6	2.8
Hand grip strength (right)	0.2	0.5	1.3	0.5	-0.6	-0.9	0.2	-0.3	-0.9	-1.2	-0.1	-0.7
Townsend deprivation index at recruitment	1.5	2.1	6.4	-1.3	1.5	2.5	1.4	1.4	2.0	0.2	0.6	0.8
Current tobacco smoking	1.8	3.0	12.7	-2.3	-0.7	3.6	-0.6	2.5	-0.0	0.7	-0.3	-1.2
Average weekly fortified wine intake	1.4	1.6	4.6	-1.7	-1.5	0.2	-2.1	-0.9	-1.2	0.5	-0.4	-1.6
Maternal smoking around birth	1.4	2.1	6.1	0.5	-0.4	-2.5	0.1	-2.2	0.0	1.7	2.0	-0.1
Fed-up feelings	0.7	1.3	3.3	0.7	1.6	0.1	1.3	-0.5	1.8	0.1	1.1	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.9	-0.1	1.3	1.7	1.7	0.2	1.5	-0.3	-1.2	0.8
Relative age voice broke	0.7	1.0	4.3	0.4	-0.7	2.1	0.3	0.9	-1.4	-0.4	-1.0	-0.5
Taking other prescription medications	0.2	0.2	0.6	-0.2	0.3	0.5	0.8	0.6	0.8	0.1	-0.1	-0.4
Age when periods started (menarche)	1.4	3.3	13.0	-0.5	-0.3	2.9	-0.6	3.6	-0.7	-0.9	-2.4	-0.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.3	0.8	1.4	1.7	1.5	1.5	1.8	-1.4	-0.7	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	2.1	0.3	0.5	-1.4	0.4	-1.0	0.4	0.1	0.3	0.1
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	6.3	-0.3	-0.9	1.4	0.7	0.9	-1.0	-2.5	-2.3	-1.4
Qualifications: CSEs or equivalent	0.5	0.6	1.7	0.3	0.9	1.0	1.3	0.7	0.6	0.7	-0.1	0.6
Serious illness, injury or assault to yourself	2.6	3.1	5.6	1.5	2.2	-1.5	1.5	-0.4	2.4	1.9	1.9	1.9
High blood pressure	1.4	4.0	7.9	1.6	1.8	-2.3	1.0	-2.3	2.2	1.9	2.8	1.6
Hayfever, allergic rhinitis or eczema	0.6	1.2	6.5	0.7	-0.4	-2.6	0.6	-1.7	-0.5	-0.5	0.2	-0.3
Multivitamins +/- minerals	0.2	0.3	1.5	-0.6	0.3	0.3	-0.1	1.2	0.4	-0.4	0.4	0.0
Stomach or abdominal pain in last month	1.4	1.7	5.6	-0.3	1.9	0.9	1.3	0.3	2.4	1.1	1.1	1.2
Supplements: Glucosamine	0.6	0.7	3.0	-0.8	-0.7	0.2	-1.7	1.0	-0.7	-0.0	0.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.8	0.3	1.1	-0.2	-0.1	-0.7	1.5	1.7	1.2	0.7
Medication: Atenolol	0.4	0.5	2.1	-1.4	-0.5	0.5	-0.9	-0.1	-0.5	-0.4	0.5	-0.8
Medication: Levothyroxine sodium	0.4	0.8	2.5	-0.5	0.0	0.4	0.5	1.5	-0.6	-1.0	-1.6	-0.3
Sitting height	0.1	1.0	3.1	0.3	-0.4	-1.2	0.8	0.6	-0.9	-1.8	-1.4	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	2.1	0.3	-0.0	-0.3	0.1	-1.4	0.0	0.3	1.4	-0.4
High blood pressure (mother)	0.2	0.3	0.7	-0.1	-0.7	0.0	-0.1	-0.4	-0.6	-0.8	-0.6	-0.5
Body mass index (BMI)	1.7	7.2	14.4	2.3	3.8	-1.9	3.3	-1.6	3.6	1.4	0.9	3.4
Impedance of leg (left)	0.6	3.0	8.3	-1.4	-2.9	0.6	-1.8	1.0	-2.3	-0.3	-0.2	-2.5
Leg predicted mass (left)	0.8	4.1	9.5	1.9	3.1	-1.3	2.9	-0.4	2.2	-0.1	-0.5	2.8
Trunk fat mass	1.4	6.1	11.9	2.5	3.5	-2.0	3.2	-0.6	3.2	1.0	0.3	3.3
Waist circumference	1.4	5.3	11.3	2.2	3.4	-1.1	3.3	-0.5	3.0	0.5	0.2	3.1
Number of incorrect matches in round	1.4	2.3	4.7	1.0	1.4	1.0	1.9	1.3	1.5	-2.0	-2.2	0.7
Past tobacco smoking	1.0	1.8	6.9	1.1	-1.1	0.1	-0.3	0.3	-2.0	-1.7	-2.6	-0.4
Alcohol usually taken with meals	2.4	3.8	10.0	1.1	-2.0	-3.2	-1.6	-2.5	-2.4	1.0	1.7	-0.8
Nervous feelings	2.5	4.6	11.4	-1.2	-3.4	0.5	-1.6	0.5	-3.4	-2.0	-1.3	-3.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.3	-0.8	0.2	1.6	0.6	0.9	0.3	-1.8	-1.8	-0.3
Hearing difficulty/problems with background noise	0.5	0.8	2.1	-1.0	-1.0	-0.7	-1.1	-0.3	-1.5	-0.0	0.3	-1.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	0.1	0.7	-0.4	-0.5	-0.2	-0.8	-0.1	-0.6	0.9
Had menopause	0.4	0.6	1.1	-0.6	-0.8	-1.0	-0.5	-0.7	-0.9	-0.6	0.1	-1.0
Had other major operations	1.9	2.3	5.8	2.3	0.3	-2.4	1.5	-1.7	0.6	0.7	1.6	0.9
Forced vital capacity (FVC)	0.1	0.5	1.8	-0.2	0.1	-0.4	-1.1	0.2	-0.4	1.0	1.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.4	-0.5	-0.6	-1.2	-0.5	0.2	-0.2	0.2	0.7	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	0.7	0.8	0.7	-0.0	-0.3	0.8	1.1	1.2	1.1
Qualifications: None of the above	0.7	1.6	5.7	-2.4	-0.4	1.5	-0.7	1.4	-0.3	-1.0	-1.3	-1.0
Financial difficulties in last 2 years	1.4	1.9	4.8	0.8	2.0	1.7	0.6	1.0	2.2	0.7	-0.2	1.4
Mouth/teeth dental problems	0.6	0.9	1.5	-0.8	-1.2	0.3	-1.1	1.1	-1.2	-0.6	-0.8	-0.9
Heart attack	0.6	0.7	1.7	-0.2	-1.3	-1.3	-0.6	-0.7	-0.8	-0.6	0.4	-1.0
Allergy	0.5	1.2	7.3	-0.3	-0.1	2.7	-0.7	1.3	-0.0	0.3	-1.0	0.3
Pain all over the body in last month	0.6	0.6	3.4	0.2	-0.1	-1.1	0.4	-0.5	0.3	0.5	1.8	0.3
Diabetes (self-reported)	3.1	4.8	11.6	3.4	2.4	-1.6	3.1	-1.5	2.2	-0.2	-0.2	2.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.6	-1.5	-1.7	-1.0	-0.7	-0.9	-1.9	0.0	-0.2	-1.5
Medication: Ramipril	0.8	1.0	3.2	0.4	0.6	-1.8	-0.2	-1.7	0.9	0.7	1.0	0.5
Medication: Simvastatin	2.0	2.9	6.0	2.1	2.3	-0.8	2.4	0.1	2.5	-0.3	0.7	2.0
Fluid intelligence score	0.2	0.5	0.9	0.9	0.8	0.6	0.7	0.4	0.3	-0.8	-0.6	0.9
Illnesses of siblings	2.6	3.6	8.9	-1.8	-1.3	1.6	-1.4	2.6	-1.9	-1.9	-3.0	-1.0
Neuroticism score	0.4	0.7	2.0	0.2	-0.8	1.0	-0.1	1.2	-0.7	-1.4	-0.8	-0.6
Weight	1.4	6.9	14.6	2.5	3.8	-2.2	3.3	-1.3	3.2	0.9	0.4	3.5
Impedance of arm (right)	0.8	3.9	5.8	-2.1	-2.2	2.3	-2.2	2.4	-2.0	-0.6	-0.5	-2.1
Arm fat percentage (right)	1.2	4.6	10.6	1.8	3.2	-1.2	2.9	-0.7	2.9	1.0	0.4	2.8
Trunk fat-free mass	0.4	2.4	5.5	1.2	2.1	-1.7	2.3	-1.3	1.1	-0.7	-0.8	1.7
Hip circumference	1.0	4.3	11.5	1.3	3.4	-1.5	2.4	-0.7	2.9	0.9	0.3	2.8
Time employed in main current job	0.2	0.2	0.8	0.4	-0.3	-0.9	-0.2	-0.3	-0.5	-0.2	0.3	-0.0
Alcohol intake versus 10 years previously	1.5	2.2	6.3	0.9	1.8	0.6	2.5	0.5	1.5	-1.4	-1.8	1.1
Father’s age at death	2.4	3.3	5.3	-2.0	-1.8	1.5	-2.2	1.3	-2.3	-1.8	-1.6	-1.6
Worrier / anxious feelings	1.8	3.4	7.5	-1.0	-2.7	1.3	-2.2	1.7	-2.3	-0.9	-1.0	-2.4
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.6	1.4	2.7	0.9	2.8	0.4	2.5	-0.5	-1.9	2.1
Falls in the last year	1.1	1.6	3.1	-0.0	1.7	1.0	1.5	1.2	1.8	0.3	-0.4	1.7
Hair/balding pattern: Pattern 3	1.4	2.1	5.6	0.2	1.2	-0.0	1.2	-1.4	2.4	2.1	2.0	0.5
Number of live births	0.8	1.2	4.2	-0.9	-1.2	-0.4	-2.1	-0.7	-1.6	0.3	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.8	1.2	0.9	-1.2	0.0	-0.7	0.1	1.0	1.0	1.3
Pulse rate	1.5	2.5	4.6	1.5	1.4	0.1	2.1	-0.3	2.1	1.6	1.9	1.6
Happiness	0.2	0.3	0.7	0.0	0.7	0.9	0.4	-0.3	0.7	0.1	0.0	0.5
Noisy workplace	0.4	0.5	2.1	-0.8	-0.6	1.4	0.3	0.8	-0.1	0.5	-0.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	1.1	0.3	-1.0	1.1	-1.0	-0.8	0.3	0.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.2	-1.1	-0.7	1.5	-0.8	1.1	-1.0	-0.5	-0.5	-1.5
Mouth/teeth dental problems: Dentures	0.3	0.6	1.5	-1.2	-0.5	1.1	-0.4	1.2	0.2	0.0	-0.1	-0.7
Asthma	0.3	0.6	1.3	-1.1	-1.1	-0.7	-0.7	-0.1	-0.7	-0.2	0.6	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	6.2	2.1	2.0	-1.2	1.6	-0.8	1.2	0.6	-0.3	2.5
Medication: Cholesterol lowering	0.3	0.5	2.0	0.1	0.1	0.7	1.4	0.5	0.5	-1.1	-0.4	-0.4
Depression (self-reported)	1.2	1.5	5.5	0.0	0.2	1.2	0.9	1.5	0.7	-2.4	-1.7	0.2
Medication: Lansoprazole	1.0	1.2	3.5	-1.4	-1.1	1.9	-0.6	1.1	-0.4	-0.7	0.5	-1.2
Prospective memory result	0.7	0.9	2.3	0.8	1.2	0.0	-0.1	0.1	1.5	1.1	0.3	1.5
Lung cancer (father)	1.2	1.4	5.9	0.7	0.6	-0.8	0.5	-1.1	0.7	1.4	2.4	1.1
Illnesses of mother	0.2	0.2	0.9	0.2	0.4	0.3	0.5	-0.6	-0.5	0.1	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	6.7	2.6	1.9	-2.2	0.5	-1.2	1.1	1.1	1.3	2.4
Pulse wave Arterial Stiffness index	1.2	1.3	2.7	-0.7	-1.3	-1.1	-1.2	-1.2	-0.8	1.4	1.6	-0.9
Impedance of arm (left)	0.9	4.2	8.3	-1.5	-2.5	1.9	-2.2	2.9	-2.4	-1.0	-0.9	-2.1
Arm fat mass (right)	1.4	5.7	12.6	2.1	3.5	-1.6	3.2	-1.0	3.1	0.9	0.4	3.1
Trunk predicted mass	0.4	2.3	5.4	1.2	2.1	-1.6	2.3	-1.3	1.1	-0.7	-0.9	1.7
Standing height	0.1	0.6	1.8	0.4	0.1	-1.1	0.5	0.4	-0.8	-1.4	-1.1	0.2
Length of working week for main job	0.7	0.8	2.1	-1.5	-0.9	1.3	-0.8	0.1	-0.3	0.3	0.1	-1.3
Exposure to tobacco smoke at home	1.1	1.2	2.6	1.3	0.8	0.0	1.6	-1.3	1.1	-0.8	-1.4	0.4
Breastfed as a baby	0.4	0.5	1.6	-0.9	-1.0	-0.2	-0.8	-0.0	-0.6	-0.6	-0.2	-1.3
Tense / ‘highly strung’	0.4	0.7	2.0	-0.0	-1.2	0.4	0.2	-0.5	-0.8	-1.4	-0.6	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.4	-0.2	0.3	0.0	-0.1	0.7	0.9	0.7	-0.7
Hair/balding pattern: Pattern 4	0.9	2.2	8.9	-0.9	-2.1	-0.1	-3.0	0.0	-1.6	-0.0	0.5	-1.6
Birth weight of first child	0.3	0.6	3.8	0.7	0.1	-1.9	0.6	-0.8	-0.1	0.2	0.5	0.2
Peak expiratory flow (PEF)	1.0	2.3	5.5	2.2	1.4	-2.4	1.2	-1.8	0.7	0.7	0.6	1.7
Pulse wave reflection index	1.5	1.8	4.2	-1.6	-1.7	-0.7	-2.1	-0.6	-1.9	0.5	-0.0	-1.5
Ever highly irritable/argumentative for 2 days	0.4	0.4	2.6	-0.4	-0.2	0.5	-0.1	0.5	0.1	0.7	1.6	-0.0
Loud music exposure frequency	1.4	1.5	2.5	1.1	1.5	-1.3	1.2	-1.0	1.3	0.6	1.3	1.6
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	7.2	2.2	1.4	-0.8	2.7	-0.9	0.8	0.4	0.6	1.2
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.6	1.1	1.8	-0.8	2.1	-2.1	1.8	0.9	0.7	1.2
Blood clot in the leg (DVT)	0.4	0.5	1.5	0.5	0.9	-0.1	1.2	0.4	0.7	-1.1	0.6	0.4
Medication: Paracetamol	0.6	0.9	2.5	0.1	1.5	0.2	0.5	0.2	1.6	1.1	0.7	1.2
Headache pain in last month	0.4	0.7	1.4	0.2	-1.0	0.0	-0.5	-0.5	-0.9	1.1	1.2	-0.9
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	0.4	0.6	0.3	-0.3	0.1	-0.0	0.0	-0.6	0.8
Glaucoma (self-reported)	2.6	3.0	7.1	1.3	1.3	-2.7	0.9	-2.5	1.2	1.3	1.8	1.8
Gout (self-reported)	0.1	0.2	0.9	0.1	0.3	0.0	0.3	0.9	0.3	0.0	-0.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.0	-0.5	0.6	0.4	0.6	1.4	0.2	-0.0	-0.1	0.1
Medication: Amlodipine	2.0	2.9	5.0	1.7	2.2	-1.5	2.2	-0.8	1.9	0.8	1.0	2.2
Medication: Ventolin 100micrograms inhaler	1.9	2.4	8.0	-1.6	-1.3	1.4	-0.7	2.8	-1.3	-1.3	-0.7	-1.7
Birth weight	0.2	0.5	1.6	-1.0	-0.3	-0.6	-1.1	0.1	0.3	1.2	0.6	-0.2
Chronic bronchitis/emphysema (mother)	2.0	2.3	7.1	-1.1	-1.5	2.0	-1.0	2.7	-0.6	0.5	1.7	-1.4
High blood pressure (siblings)	1.3	1.8	6.7	0.6	0.2	-1.0	-0.3	-1.8	0.6	2.2	2.6	0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	1.8	1.4	1.0	-1.3	-0.3	-0.3	0.4	0.7	1.2	1.3
Body fat percentage	1.2	4.6	9.1	2.0	2.9	-1.5	2.6	-0.5	3.0	1.4	0.6	2.8
Leg fat percentage (right)	1.6	5.7	12.0	2.2	3.1	-1.6	2.9	-1.5	3.5	1.4	0.6	2.9
Arm fat-free mass (right)	0.8	4.1	8.1	2.1	2.7	-2.4	2.9	-1.4	1.8	-0.2	-0.3	2.5
Exposure to tobacco smoke outside home	1.1	1.5	3.6	0.8	1.2	0.7	1.9	-0.5	1.6	-1.5	-1.5	0.4
Comparative body size at age 10	0.9	2.5	4.9	1.6	1.9	-1.5	1.8	-2.2	1.6	0.9	0.2	1.6
Number of full brothers	0.2	0.2	0.7	-0.5	0.7	0.2	0.2	0.4	0.9	-0.2	-0.2	-0.1
Worry too long after embarrassment	1.3	2.2	4.9	-1.0	-2.1	0.2	-1.5	0.4	-2.2	-1.5	-0.6	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.6	0.2	1.3	1.1	0.7	1.3	1.6	0.2	-0.3	0.4
Wheeze or whistling in the chest in last year	1.2	2.2	4.7	-1.6	-1.4	0.8	0.4	1.3	-1.6	-2.1	-0.8	-2.2
Number of children fathered	1.4	1.6	5.3	0.6	0.4	1.0	-1.1	0.3	1.4	2.3	2.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.1	-0.1	0.0	-0.3	-0.4	-0.3	0.5	0.5	1.1	-0.3
Age at first live birth	1.2	2.1	6.3	0.1	-1.5	-0.0	-0.5	1.3	-1.4	-2.1	-2.5	-1.1
Pulse wave peak to peak time	1.1	1.3	2.9	0.4	1.1	1.0	1.0	1.4	0.7	-1.4	-1.7	0.7
Health satisfaction	1.5	1.9	4.7	1.1	2.2	-0.1	1.9	-0.3	2.2	-0.2	0.1	1.6
Shortness of breath walking on level ground	4.7	5.5	11.8	2.4	3.4	-0.4	3.3	0.8	3.4	0.5	-0.2	2.9
Qualifications: College or University degree	0.2	0.7	2.2	0.4	-0.9	-0.4	-0.6	-0.4	-1.3	-0.8	-1.5	-0.2
Eye problems/disorders: None of the above	0.2	0.2	0.8	-0.0	0.1	0.6	0.3	-0.3	-0.1	-0.3	-0.9	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	-0.3	-0.4	-1.0	-0.2	-1.2	-0.5	-0.0	0.2	-0.6
Emphysema/chronic bronchitis	0.6	0.7	2.3	-1.1	0.1	0.7	-0.1	0.0	0.3	1.2	1.5	-0.6
Medication for pain relief, constipation, heartburn	0.8	1.3	3.2	-0.9	-1.4	1.1	-1.8	0.9	-1.4	-0.4	0.2	-1.2
Neck or shoulder pain in last month	1.4	1.9	3.6	1.0	1.7	-1.7	0.8	-1.4	1.9	1.4	0.9	1.3
Medication: Blood pressure	1.0	1.7	7.3	-0.6	-0.6	-1.8	-0.8	-0.6	-0.0	1.7	2.7	-0.7
Angina (self-reported)	0.6	0.8	3.3	0.9	0.7	-0.7	1.8	-0.6	1.0	-0.4	0.1	0.3
Migraine (self-reported)	1.0	1.2	4.9	0.7	0.0	-1.1	0.0	-1.2	0.0	1.8	2.2	0.1
Medication: Ibuprofen	2.6	3.1	7.3	2.2	2.2	-1.1	1.7	-1.3	1.8	1.1	0.4	2.7
Medication: Allopurinol	0.4	0.6	1.7	-0.3	0.3	0.0	0.6	1.3	0.3	-1.2	-0.9	0.5
Medication: Omeprazole	0.3	0.4	0.9	0.4	0.4	-0.9	1.0	-0.3	0.7	-0.1	0.7	-0.0
Medication: Seretide 50 evohaler	2.0	2.3	6.2	-1.3	-2.5	0.6	-0.9	1.1	-2.2	-0.9	-0.5	-2.2
Mean time to correctly identify matches	1.3	2.5	5.9	-0.9	-1.6	-0.9	-2.0	-1.3	-1.3	1.3	2.4	-1.9
Heart disease (mother)	0.7	0.9	3.7	-0.7	0.3	0.4	-0.3	-0.7	0.9	1.3	1.9	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	2.9	-0.9	-1.2	-0.8	-1.7	-0.1	-1.3	1.1	1.7	-1.0
Whole body fat mass	1.1	4.7	9.6	1.9	3.1	-1.5	2.7	-0.6	3.0	1.0	0.4	2.9
Leg fat mass (right)	1.4	5.6	11.0	2.1	3.3	-1.7	2.9	-1.2	3.3	1.2	0.5	3.1
Arm predicted mass (right)	0.7	3.5	6.9	1.9	2.5	-2.2	2.6	-1.3	1.6	-0.3	-0.5	2.2
Pulse rate, automated reading	1.3	4.3	10.6	1.5	1.6	-1.9	1.9	-2.1	1.9	2.4	3.3	1.6
Alcohol intake frequency.	1.2	2.7	5.8	1.6	2.2	-1.0	2.0	0.2	2.1	1.0	0.9	2.4
Comparative height size at age 10	0.3	1.5	5.3	-1.0	0.3	-2.3	-0.7	-0.7	0.7	0.9	2.3	0.1
Number of full sisters	1.7	2.1	8.5	0.5	0.7	0.4	0.6	0.7	1.4	2.9	2.4	0.7
Suffer from ‘nerves’	0.3	0.5	1.3	-0.1	-0.6	-0.6	-0.7	-1.1	-0.4	-0.8	-0.7	-0.7
Overall health rating	2.1	4.4	13.2	1.8	3.3	-0.2	2.4	-0.1	3.6	0.8	0.2	2.5
Chest pain or discomfort	3.1	4.5	9.1	3.0	2.8	-0.8	2.8	-0.5	2.8	0.6	0.5	2.5
Had major operations	0.3	0.4	1.0	-0.0	-0.1	0.9	0.8	1.0	0.6	-0.5	-0.3	0.1
Age at last live birth	1.3	1.9	6.0	-0.8	-1.0	1.0	-0.3	1.4	-1.4	-1.8	-2.5	-1.0
Family relationship satisfaction	1.2	1.5	3.2	1.2	1.8	0.2	1.0	1.1	1.3	0.5	1.5	1.4
Leg pain on walking	1.3	1.7	3.0	1.3	1.6	1.4	1.7	0.2	1.7	0.2	-0.6	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.6	1.0	1.3	0.0	1.9	0.8	1.5	1.1	1.1	1.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.0	-0.9	-1.8	-0.6	-1.6	-1.1	-2.0	-0.2	-0.4	-1.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	4.3	0.7	-1.1	-1.9	-1.1	-2.1	-0.9	-0.5	0.2	-0.5
Medication: Aspirin	0.2	0.3	0.7	0.4	-0.2	-0.9	0.4	-0.3	0.8	0.6	0.3	-0.1
Supplements: Vitamin C	0.5	0.6	1.4	0.6	1.2	0.4	0.5	0.9	1.0	-0.5	-0.6	0.8
Knee pain experienced in last month	0.4	0.7	1.9	-0.3	1.4	0.6	0.4	-0.4	1.1	-0.6	-1.3	0.7
Hypertension (Self-reported)	1.2	3.3	5.4	1.7	2.0	-1.7	1.4	-2.1	2.3	1.2	2.1	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	13.1	-0.3	0.2	0.3	-0.1	-1.7	0.9	2.4	3.6	-0.3
Illnesses of father: Heart disease	2.1	2.9	8.2	2.0	1.2	-2.6	0.3	-2.9	1.2	1.3	1.0	1.3
Illnesses of siblings: Diabetes	1.5	1.9	5.2	1.2	1.6	-0.2	1.8	-2.3	1.8	-0.2	0.5	0.9
Smoking status: Previous	1.4	2.1	7.0	-0.5	1.1	-1.5	0.6	-1.7	1.6	1.4	2.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.6	0.9	1.9	0.9	1.7	1.7	1.6	-0.9	-1.3	1.7
Whole body fat-free mass	0.6	3.4	7.3	1.7	2.7	-1.8	2.7	-1.1	1.8	-0.2	-0.5	2.4
Leg fat-free mass (right)	0.7	4.0	9.1	2.1	3.0	-1.6	2.7	-0.3	2.1	0.2	-0.2	2.9
Arm fat percentage (left)	1.1	4.6	10.1	2.0	3.2	-1.2	2.9	-0.5	2.8	0.8	0.2	2.9
Average weekly red wine intake	0.4	0.5	2.0	0.8	-0.2	-0.8	0.8	-1.4	-0.1	0.0	0.9	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.3	0.3	0.4	-1.1	-0.4	-1.0	0.7	0.8	1.1	0.4
Mood swings	0.3	0.6	1.2	0.7	0.9	0.9	0.7	0.8	1.1	-0.4	-0.5	0.6
Loneliness, isolation	0.9	1.3	3.5	-1.0	-0.5	0.9	1.3	0.5	-0.3	-1.9	-1.5	-1.1
Long-standing illness, disability or infirmity	0.9	1.4	4.4	0.4	2.1	-0.1	1.1	0.9	1.9	-0.3	0.5	1.3
Ever had bowel cancer screening	0.7	0.9	1.9	-1.1	-1.3	0.7	-0.6	-0.6	-0.6	0.1	1.1	-1.4
Diabetes diagnosed by doctor	4.3	7.1	16.2	3.9	3.1	-1.4	4.0	-1.7	2.7	0.2	-0.1	3.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.9	1.2	0.2	-1.7	0.5	-0.2	0.1	0.7	0.6	0.8
Friendships satisfaction	0.3	0.3	1.1	0.1	0.1	0.8	-0.1	1.1	0.2	0.6	0.8	0.2
Qualifications: nursing, teaching	0.2	0.3	0.9	0.1	0.0	-0.3	-0.6	-0.3	-0.1	1.0	0.9	0.1
Commuting to job workplace: Walk	2.9	3.2	10.2	1.1	2.7	-0.6	1.7	-0.4	3.2	1.3	0.5	2.2
Eye problems/disorders: Cataract	0.9	1.1	2.3	0.7	1.5	-0.5	0.5	1.4	1.3	-0.5	-0.1	1.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.8	1.3	1.2	-1.2	1.0	-1.4	0.8	0.8	1.7	1.1
Medication for cholesterol	1.4	2.1	5.2	-1.9	-1.0	1.5	-1.8	2.3	-1.4	-0.2	-0.5	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.1	-0.9	0.6	0.5	1.1	0.8	0.3	-1.4	-0.2	-0.1
Back pain experienced in last month	0.7	1.0	3.7	-0.2	1.1	0.4	1.2	-0.4	1.9	0.4	1.5	0.2
Mineral and other dietary supplements	1.8	2.5	5.4	0.9	2.3	-0.4	1.7	-1.1	2.1	1.2	1.3	2.1
Breast cancer (self-reported)	0.2	0.2	1.5	0.0	0.3	-1.2	-0.4	-0.4	0.3	0.1	0.4	-0.0
Asthma (self-reported)	0.2	0.5	1.1	-1.0	-1.0	-0.6	-0.6	-0.2	-0.5	0.0	0.6	-1.0
Osteoporosis (self-reported)	2.2	2.7	7.0	-2.6	-1.4	1.2	-2.2	1.8	-0.7	0.4	-0.1	-2.3
Osteoarthritis (self-reported)	0.5	0.7	1.7	0.6	1.0	-0.1	1.3	-0.2	1.2	0.1	-1.1	0.8
Medication: Aspirin	0.2	0.3	0.9	0.1	-0.7	-1.0	0.0	-0.6	0.2	0.6	0.6	-0.6
Medication: Gliclazide	3.0	3.4	9.6	2.0	2.0	0.6	3.1	-1.7	1.9	-1.1	-1.6	1.3
Illnesses of father: None of the above (group 1)	1.4	1.7	4.9	-0.9	-0.7	2.2	0.4	2.2	-0.4	-1.3	-1.4	-0.9
Smoking status: Current	1.9	3.0	11.0	-2.3	-0.7	3.3	-0.8	2.7	-0.0	0.4	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	10.2	2.7	2.0	-3.2	1.0	-1.0	1.5	0.5	1.2	2.3
Whole body water mass	0.6	3.4	7.4	1.7	2.7	-1.8	2.7	-1.0	1.7	-0.4	-0.6	2.4
Leg predicted mass (right)	0.7	3.8	8.8	2.0	3.0	-1.5	2.6	-0.3	2.0	0.2	-0.3	2.8
Arm fat mass (left)	1.2	4.9	11.1	1.9	3.3	-1.6	3.1	-0.7	2.9	0.7	0.2	2.9
Number of self-reported non-cancer illnesses	1.2	2.1	6.1	0.9	2.0	-0.6	2.2	-0.8	2.5	0.1	0.5	1.3
Average weekly champagne plus white wine intake	1.5	2.1	3.9	2.0	1.6	-1.2	1.7	-1.2	1.4	-1.2	-0.4	1.8
Miserableness	0.3	0.5	1.6	0.3	0.6	1.2	0.4	0.8	1.0	0.4	0.5	0.5
Guilty feelings	0.3	0.4	0.8	0.6	0.8	0.5	0.5	0.5	0.9	-0.1	0.5	0.9
Wears glasses or contact lenses	2.0	2.3	3.9	0.8	1.9	-0.8	0.0	-1.2	1.8	2.0	2.0	1.9
Ever taken oral contraceptive pill	1.0	1.1	4.8	0.1	0.9	-0.0	-0.6	-0.2	1.1	2.2	1.6	0.5
Hearing aid user	0.7	0.8	3.6	1.5	-0.0	-1.9	0.2	0.2	0.7	-0.2	0.8	0.2
Mother’s age at death	0.1	0.2	0.6	0.6	0.0	0.8	0.0	0.5	-0.2	-0.2	-0.3	0.5
Financial situation satisfaction	1.1	1.4	3.9	0.6	1.9	0.0	-0.0	0.3	1.8	1.3	0.3	2.0
Tinnitus: Yes, now most or all of the time	1.0	1.2	5.7	-0.5	0.5	-0.4	-0.8	0.2	1.0	1.4	2.4	0.7
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.2	0.7	0.6	0.8	-0.2	0.8	0.3	0.6	0.4
Eye problems/disorders: Glaucoma	1.1	1.3	2.6	1.1	0.8	-1.6	0.4	-1.5	1.0	1.0	0.7	1.5
Medication: Blood pressure	1.4	2.8	6.0	2.0	1.6	-1.8	2.0	-2.5	1.6	0.0	0.7	1.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.7	0.8	1.1	-0.0	0.3	0.7	1.6	0.1	-0.7	1.0
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.1	-0.9	-2.0	0.8	-2.0	1.7	-1.5	-0.1	-0.5	-1.4
High cholesterol (Self-reported)	1.1	1.9	5.0	1.6	1.6	-0.3	2.1	-1.0	2.2	-0.1	0.6	1.2
Medication: Bendroflumethiazide	0.7	1.1	1.9	-1.1	-1.0	-0.8	-1.4	-1.0	-0.1	1.4	1.2	-1.0
Medication: Paracetamol	0.5	0.8	2.0	0.0	1.2	0.4	0.6	-0.4	1.4	1.0	0.9	1.0
Medication: Lisinopril	0.7	0.9	2.8	-1.3	-0.6	0.7	-1.7	1.2	-0.3	1.1	0.4	-0.5
Medication: Atorvastatin	0.3	0.3	1.6	0.5	-0.4	-0.0	0.7	-1.3	0.1	0.4	-0.4	-0.3
Illnesses of father: High blood pressure	0.2	0.2	0.9	-0.4	0.4	-0.1	-0.9	-0.6	0.4	0.3	-0.4	0.2
Alcohol drinker status: Never	1.2	1.4	4.5	-0.1	0.2	1.5	0.4	1.4	0.1	-1.8	-2.1	-0.3
Ever smoked	0.7	1.3	2.6	-1.5	0.2	1.6	-0.3	0.9	1.2	1.4	1.6	-0.2
Basal metabolic rate	0.7	4.0	8.8	1.8	3.0	-1.9	2.9	-1.0	2.0	-0.1	-0.5	2.6
Leg fat percentage (left)	1.7	6.3	12.7	2.4	3.2	-1.9	3.0	-1.6	3.6	1.8	0.9	3.0
Arm fat-free mass (left)	0.6	3.2	6.4	1.6	2.5	-2.0	2.3	-1.5	1.8	0.2	0.0	2.2
Number of operations (self-reported)	0.4	0.6	2.4	0.8	-0.6	-0.7	0.8	-0.5	-0.0	0.1	1.5	-0.6
Average weekly beer plus cider intake	3.4	5.0	11.4	2.2	3.2	-0.3	3.4	-0.6	3.0	-0.9	-0.5	2.8
Irritability	0.8	1.4	5.0	0.2	0.5	0.7	0.7	2.2	0.4	-2.1	-1.3	0.4
Risk taking	1.0	1.4	3.6	1.0	1.9	-0.9	1.6	-0.5	1.6	0.2	-0.5	1.3
Ever had prostate specific antigen (PSA) test	2.7	3.1	9.9	0.1	-1.8	-2.5	-1.8	-3.1	-1.4	0.7	1.4	-1.1
Fractured/broken bones in last 5 years	0.9	1.2	3.8	1.4	1.3	-0.3	2.0	0.9	1.0	-0.6	0.0	1.0
Age started oral contraceptive pill	2.9	3.7	9.7	-1.3	-2.7	0.6	-2.2	0.3	-3.1	-1.6	-0.6	-2.5
Diastolic blood pressure, automated reading	0.5	1.5	4.3	-0.9	-1.8	-0.6	-0.8	-0.7	-2.1	0.2	0.4	-1.8
Ever depressed for a whole week	0.6	0.8	1.5	0.9	0.8	-0.0	0.2	-0.9	1.0	1.2	1.1	1.1
Unable to work because of sickness or disability	1.8	2.3	5.6	1.0	2.4	-0.6	1.9	-0.9	2.3	0.2	1.0	1.6
Commuting to job workplace: Cycle	1.0	1.3	3.9	-0.3	0.5	0.7	1.6	0.7	0.6	-2.0	-1.8	-0.1
Myopia	0.5	0.7	2.3	0.2	-0.3	-1.3	-0.7	-0.4	-0.5	1.5	1.0	0.5
Vascular/heart problems diagnosed by doctor	1.5	4.1	7.1	-2.0	-1.7	2.0	-1.4	2.4	-2.3	-1.7	-2.7	-1.5
Cholesterol lowering medication	4.4	6.4	9.1	3.0	2.6	-2.7	2.4	-2.5	2.8	1.7	2.0	2.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-0.3	-0.2	-1.1	0.7	-1.0	0.2	-0.3	1.2	-0.8
Pain experienced in last month	0.6	0.9	2.8	-0.4	-0.9	0.3	-0.2	1.0	-1.2	-1.7	-1.2	-0.6
Supplements: Calcium	1.4	1.6	4.0	-1.7	-1.2	1.2	-2.0	0.2	-0.9	0.0	0.8	-1.8
Basal cell carcinoma (self-reported)	0.5	0.5	2.6	-1.1	0.5	1.6	0.2	0.5	0.6	-0.3	0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.1	-0.3	-1.5	-1.2	-0.7	-0.8	-0.9	-0.7	0.5	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	0.5	1.1	-0.3	1.2	0.4	0.7	-1.1	0.4	0.6
Heart disease (siblings)	1.6	2.0	4.2	1.1	1.3	-2.1	2.0	-1.5	1.6	0.2	1.0	0.9
Alcohol drinker status: Previous	2.9	3.3	6.9	1.6	2.5	-0.1	2.2	-0.6	2.6	0.6	1.7	2.3
Pack years of smoking	0.9	1.3	6.5	0.2	0.4	1.1	0.7	1.0	0.5	-1.3	-2.5	0.4
Impedance of whole body	0.5	2.5	5.4	-1.0	-2.3	1.2	-1.8	1.9	-2.0	-0.4	-0.3	-1.9
Leg fat mass (left)	1.5	5.9	11.5	2.3	3.4	-1.9	3.0	-1.2	3.4	1.2	0.5	3.2
Arm predicted mass (left)	0.8	3.8	7.6	1.9	2.8	-2.2	2.5	-1.4	2.0	0.3	0.1	2.5