Hub : Genes

SMCO4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0779 0.0369 8.1e-03 0.009 NA 0.004 NA 0.007 6.2e-02 NA 1.4e-01 NA 8.5e-02
2 GTEx Colon Transverse 0.2860 0.0640 1.2e-08 0.245 NA 0.183 NA 0.196 5.3e-12 NA 4.3e-09 NA 1.2e-09
3 GTEx Esophagus Mucosa 0.3030 0.0640 5.4e-09 0.030 NA 0.115 NA 0.119 4.2e-03 NA 4.0e-08 NA 2.6e-08
4 GTEx Pancreas 0.2080 0.0580 2.4e-05 0.046 NA 0.085 NA 0.044 5.0e-03 NA 1.9e-04 NA 6.0e-03
5 GTEx Testis 0.1420 0.0570 4.5e-03 -0.002 NA -0.005 NA -0.006 4.0e-01 NA 5.9e-01 NA 9.4e-01
6 GTEx Thyroid 0.1060 0.0490 5.2e-03 0.016 NA -0.001 NA -0.004 2.1e-02 NA 4.1e-01 NA 9.8e-01
7 GTEx Whole Blood 0.1780 0.0530 3.1e-05 0.146 NA 0.122 NA 0.140 2.2e-13 NA 2.7e-11 NA 7.0e-13
8 METSIM Adipose 0.0957 0.0279 8.3e-08 0.063 0.070 0.077 0.072 0.073 9.4e-10 1.2e-10 1.3e-11 6.5e-11 4.5e-11
9 ROSMAP Brain Pre-frontal Cortex 0.0809 0.0261 2.0e-06 0.069 0.056 0.076 0.071 0.084 2.8e-09 1.1e-07 4.7e-10 2.0e-09 6.4e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.2 0.3 1.1 0.3 -0.4 0.8 0.3 0.9 -0.4 -0.1 -1.0 0.0
Bipolar Disorder or Schizophrenia 0.5 1.3 3.0 -0.2 -1.5 1.2 -0.6 1.4 -1.2 -0.3 -1.7 -1.1
Depressed Affect (Nagel 2018) 0.5 1.0 2.4 0.6 1.1 1.3 1.4 0.3 1.5 -0.6 -0.2 0.9
Depression (Nagel 2018) 1.4 2.1 3.8 0.3 1.6 1.8 1.8 0.3 1.9 -1.2 -2.0 1.2
Intelligence (Savage-Jansen 2018) 0.7 2.0 6.3 2.5 1.6 -1.7 1.4 0.0 0.6 -0.1 0.8 1.9
Neuroticism (Nagel 2018) 0.7 1.7 4.3 -0.0 -1.0 2.0 0.2 0.9 -0.4 -2.1 -1.9 -1.0
Schizophrenia (2018) 0.6 1.3 2.4 -0.4 -1.6 0.9 -1.0 1.0 -1.3 -0.4 -1.4 -1.4
Schizophrenia vs Biploar Disorder 0.6 0.7 3.3 0.5 -0.1 -0.5 0.6 -0.6 0.5 1.4 1.8 0.1
Worry (Nagel 2018) 1.6 3.4 7.6 -1.0 -2.7 0.7 -1.4 0.3 -2.2 -1.9 -1.9 -2.8
Alzheimer’s Disease (in mother) 0.7 0.8 1.8 0.1 0.7 -1.2 -1.1 0.9 1.0 0.4 0.7 1.3
Alzheimer’s Disease (in father) 0.3 0.4 1.3 -0.6 -0.3 -0.3 -0.9 0.2 -0.4 0.7 1.1 0.1
Alzheimer’s Disease (including proxy) 0.4 0.5 1.3 -0.3 0.1 -1.1 -1.1 0.4 0.2 0.5 1.1 0.7
Crohns Disease (2017) 0.7 1.5 4.9 -1.0 -0.4 0.3 -1.4 -0.9 1.2 1.9 2.2 -0.3
Irritable Bowel Disease (IBD) 0.5 1.3 4.4 -0.3 -0.5 -0.3 -0.8 -1.9 0.5 1.6 2.1 -0.0
Ulcerative Colitis (UC) 0.6 1.1 4.4 0.1 -1.1 -0.8 -0.5 -2.1 -0.8 0.9 1.4 -0.4
Major Depression (MDD) 0.9 1.1 4.0 -1.5 -0.3 1.5 -0.7 2.0 -0.1 0.6 0.1 -0.5
Reaction Time 0.5 1.0 2.6 -0.8 -0.9 -0.4 -1.1 -0.5 -0.5 1.0 1.6 -1.4
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.8 1.5 1.3 0.2 1.0 0.6 0.7 -0.1 -0.4 1.7
Breast Cancer 0.2 0.4 1.0 1.0 0.1 -0.6 0.8 -0.6 0.1 0.6 0.7 0.6
Ovarian Cancer 1.2 1.6 3.4 -0.3 1.8 -1.4 0.7 -1.3 1.4 0.6 1.8 1.0
Prostate Cancer 0.3 0.4 1.9 -0.7 0.1 1.4 -0.3 -0.8 -0.0 -0.1 -0.8 -0.6
Age at First Birth 0.9 1.4 3.6 1.1 -0.5 -1.8 -0.1 -1.1 -1.2 -1.9 -1.2 -0.3
Bipolar Disorder (2011) 0.6 0.6 2.8 0.7 -0.2 0.2 0.5 -0.9 -0.1 -1.0 -1.7 -0.2
Body Mass Index (BMI) (2010) 1.3 1.8 3.2 1.5 1.4 -1.8 0.6 -1.4 1.6 0.7 1.5 1.1
Coronary Artery Disease (CAD) 1.1 1.3 2.8 1.1 1.7 -1.3 0.4 1.0 1.7 -0.2 0.3 1.4
Crohns Disease (2012) 0.3 0.4 1.4 -0.0 0.3 0.6 -0.5 -0.8 1.2 1.0 0.4 0.3
Mean Putamen Volume 0.4 0.5 2.5 0.7 0.5 -1.6 0.8 -0.2 0.2 -0.5 -0.1 0.3
Fasting Glucose 4.1 4.9 8.8 2.5 2.8 -1.6 2.6 -1.5 3.0 0.6 0.9 2.8
HbA1C 1.3 1.4 4.0 0.5 0.8 -2.0 0.7 -1.9 0.1 0.4 1.6 0.9
HDL Cholesterol 0.3 0.5 1.8 0.7 0.3 -0.0 0.6 -1.4 0.0 0.9 0.7 0.5
LDL Cholesterol 0.8 1.3 3.8 0.7 0.7 -0.1 0.4 -1.9 0.8 1.3 1.8 1.0
Lupus 0.7 1.0 2.3 -1.0 -1.5 -0.8 -1.1 1.0 -1.1 -0.4 -0.3 -1.2
Neuroticism (2016) 0.6 0.9 5.2 0.3 -0.2 2.3 0.1 1.4 -0.2 0.5 -0.7 0.1
Primary Biliary Cirrhosis 0.4 0.6 3.3 0.5 -0.6 -1.8 -0.3 -0.8 -0.8 0.3 -0.4 -0.3
Rheumatoid Arthritis 2.1 2.9 7.8 -1.2 -1.7 0.8 -1.0 1.2 -2.1 -2.8 -2.1 -1.6
Schizophrenia (2014) 0.3 0.7 2.0 -0.4 -1.4 0.1 -0.8 0.7 -1.2 0.1 -0.6 -1.2
Triglycerides 0.3 0.5 1.7 0.5 -0.0 -1.2 0.7 -1.3 -0.4 -0.7 -0.6 -0.1
Type 2 Diabetes (T2D) (2012) 1.5 1.7 7.7 1.4 0.4 -2.8 1.0 -1.2 0.2 -0.7 -1.5 0.9
Ulcerative Colitis 1.0 1.4 5.1 0.6 -1.1 -1.6 -0.5 -2.3 -1.4 0.4 1.1 -0.3
Blood Eosinophil Count 0.1 0.6 1.5 0.7 0.5 -1.2 1.2 -0.6 -0.0 0.4 0.8 0.5
Blood Platelet Count 0.1 0.7 2.2 -0.9 -1.1 -0.2 0.0 -0.4 -0.8 -1.0 -0.1 -1.5
Blood Red Count 0.1 0.5 2.0 0.8 0.1 0.5 0.0 -0.5 -0.8 1.4 -0.8 0.3
Blood White Count 0.3 2.0 7.0 1.3 1.3 1.6 2.6 0.8 0.8 -0.7 -1.5 1.1
Heel T-Score 0.1 1.1 3.8 0.6 0.2 -2.0 -0.2 -1.2 0.7 1.0 1.7 0.2
BMI 2.7 15.4 32.4 3.8 5.7 -2.3 4.5 -1.2 5.5 1.8 1.6 5.4
Height 0.0 0.7 1.7 1.1 0.9 -1.0 0.0 0.3 0.8 0.8 0.3 1.3
Waist Hip Ratio (WHR) 0.4 1.7 5.7 0.7 -0.1 1.6 1.9 2.4 -0.1 -1.1 -1.1 -0.2
Systolic Blood Pressure 0.7 3.4 9.0 -1.3 -2.8 -1.2 -1.6 -0.3 -3.0 -0.7 0.7 -2.7
Smoking Status 1.1 2.7 6.1 -2.5 -0.1 1.6 -1.4 0.7 0.7 2.4 2.4 -0.6
Allergy or Eczema 0.3 0.8 4.1 0.2 -0.8 -2.0 -0.1 -1.1 -0.5 -0.4 0.3 -0.7
Cardiovascular Disease 0.6 2.0 4.3 1.6 1.8 -0.9 2.1 -1.0 1.7 -0.9 -0.6 1.3
Hypothyroidism (self reported) 0.2 0.4 2.1 -0.4 0.2 0.5 0.6 1.4 -0.4 -0.3 -0.5 -0.3
Respiratory disease 0.2 0.5 1.2 -1.1 -0.7 0.4 0.2 0.6 -0.3 -0.8 -0.4 -1.1
Type 2 Diabetes (T2D) (2018) 4.4 8.3 21.6 4.0 3.4 -1.2 4.6 -1.4 3.1 -0.2 -1.2 3.4
Lung FEV1/FVC ratio 0.9 4.3 7.7 2.6 2.2 -1.5 1.9 -1.6 2.1 2.1 1.5 2.8
Lung FVC 0.3 1.4 5.2 0.0 0.1 -1.3 -1.5 -0.9 -0.1 1.7 2.3 0.1
Neuroticism 0.3 0.7 2.1 0.6 -0.2 1.2 0.6 1.0 -0.3 -1.4 -1.1 -0.1
Chronotype (morning person) 1.4 3.2 9.3 2.4 1.8 -1.5 0.3 -2.0 1.5 -0.3 -3.0 1.4
Hair Pigment 0.0 0.3 0.5 0.1 -0.7 0.7 -0.0 -0.6 -0.5 0.6 0.3 -0.6
Tanning 0.1 0.8 2.8 -0.4 -1.1 0.9 -0.7 0.1 -0.9 -1.7 -0.7 -0.9
Hand grip strength (left) 0.2 0.6 2.2 0.5 -0.6 -1.5 0.4 -0.5 -1.0 -1.0 -0.5 -0.6
Number of treatments/medications taken 0.1 0.2 0.6 0.2 -0.2 -0.2 0.1 0.2 0.4 0.5 0.8 -0.5
Average weekly spirits intake 0.8 1.0 3.9 -2.0 -0.6 1.4 -0.3 0.3 -0.1 -0.4 0.6 -1.5
Sensitivity / hurt feelings 0.6 1.0 3.2 1.8 -0.4 1.2 1.3 0.8 -0.6 -0.6 -1.0 0.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.6 -0.0 1.3 1.6 0.6 0.6 1.5 -0.4 -0.6 1.1
Hearing difficulty/problems: Yes 0.6 1.0 4.3 0.2 -0.2 -1.0 -0.3 -1.1 -0.5 1.3 2.1 -0.4
Relative age of first facial hair 1.0 2.0 3.9 -0.6 -1.4 1.6 0.4 0.1 -1.9 -1.9 -2.0 -1.5
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.8 -0.2 1.2 0.4 0.1 -0.2 1.7 0.4 0.5 0.6
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.6 0.8 0.1 -1.0 0.1 -1.3 0.1 0.4 1.1 -0.1
Ever had hysterectomy (womb removed) 0.4 0.4 1.4 0.4 1.0 -0.1 0.1 -0.8 1.2 -0.5 -0.3 0.3
Systolic blood pressure, automated reading 0.7 1.9 3.5 -0.2 -1.9 -1.4 -1.1 -1.4 -1.9 0.5 1.4 -1.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.4 -0.0 0.4 1.2 0.2 -0.5 0.2 -0.3 -0.8 0.3
Angina 0.4 0.5 2.3 0.8 0.5 -0.5 1.5 -0.5 0.9 -0.3 0.2 0.2
Medication for hormone replacement therapy 0.2 0.3 0.9 -0.3 -0.4 -0.5 0.1 -0.9 -0.3 -0.4 -0.5 -0.6
Vitamin and mineral supplements 0.6 0.8 3.2 0.9 -0.1 -0.8 1.2 -1.8 -0.2 0.7 -0.1 0.4
Supplements: Zinc 0.6 0.7 2.5 -0.1 -0.2 1.6 -0.1 0.8 0.4 -0.8 -1.4 -0.3
Medication: Co-codamol 0.5 0.6 1.8 0.7 1.0 0.8 0.8 0.5 1.4 0.1 0.2 0.7
Medication: Metformin 2.3 3.3 8.7 2.3 2.3 -0.5 2.9 -1.4 2.0 -0.5 -0.7 1.9
Diabetes (father) 2.9 3.6 8.0 1.9 2.5 -1.6 2.0 -0.2 2.3 1.3 1.1 2.8
Diabetes (mother) 1.5 1.9 5.1 0.7 1.4 -0.6 2.3 -1.2 1.8 1.1 1.7 1.0
Severe depression (siblings) 0.7 0.7 3.3 -0.8 -0.5 1.8 0.3 1.0 -0.2 -0.5 -1.1 -0.4
Pack years adult smoking proportion 0.9 1.3 6.1 0.3 0.5 1.2 0.8 1.3 0.4 -1.2 -2.5 0.6
Impedance of leg (right) 0.8 3.8 9.1 -1.8 -3.0 1.0 -1.8 1.1 -2.5 -1.0 -0.7 -2.9
Leg fat-free mass (left) 0.7 3.9 9.2 1.9 3.0 -1.4 2.9 -0.4 2.1 -0.1 -0.5 2.8
Trunk fat percentage 1.1 4.3 7.8 2.1 2.8 -1.7 2.6 -0.2 2.7 1.2 0.6 2.8
Hand grip strength (right) 0.2 0.5 1.3 0.5 -0.6 -0.9 0.2 -0.3 -0.9 -1.2 -0.1 -0.7
Townsend deprivation index at recruitment 1.5 2.1 6.4 -1.3 1.5 2.5 1.4 1.4 2.0 0.2 0.6 0.8
Current tobacco smoking 1.8 3.0 12.7 -2.3 -0.7 3.6 -0.6 2.5 -0.0 0.7 -0.3 -1.2
Average weekly fortified wine intake 1.4 1.6 4.6 -1.7 -1.5 0.2 -2.1 -0.9 -1.2 0.5 -0.4 -1.6
Maternal smoking around birth 1.4 2.1 6.1 0.5 -0.4 -2.5 0.1 -2.2 0.0 1.7 2.0 -0.1
Fed-up feelings 0.7 1.3 3.3 0.7 1.6 0.1 1.3 -0.5 1.8 0.1 1.1 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.9 -0.1 1.3 1.7 1.7 0.2 1.5 -0.3 -1.2 0.8
Relative age voice broke 0.7 1.0 4.3 0.4 -0.7 2.1 0.3 0.9 -1.4 -0.4 -1.0 -0.5
Taking other prescription medications 0.2 0.2 0.6 -0.2 0.3 0.5 0.8 0.6 0.8 0.1 -0.1 -0.4
Age when periods started (menarche) 1.4 3.3 13.0 -0.5 -0.3 2.9 -0.6 3.6 -0.7 -0.9 -2.4 -0.4
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 3.3 0.8 1.4 1.7 1.5 1.5 1.8 -1.4 -0.7 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 2.1 0.3 0.5 -1.4 0.4 -1.0 0.4 0.1 0.3 0.1
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 6.3 -0.3 -0.9 1.4 0.7 0.9 -1.0 -2.5 -2.3 -1.4
Qualifications: CSEs or equivalent 0.5 0.6 1.7 0.3 0.9 1.0 1.3 0.7 0.6 0.7 -0.1 0.6
Serious illness, injury or assault to yourself 2.6 3.1 5.6 1.5 2.2 -1.5 1.5 -0.4 2.4 1.9 1.9 1.9
High blood pressure 1.4 4.0 7.9 1.6 1.8 -2.3 1.0 -2.3 2.2 1.9 2.8 1.6
Hayfever, allergic rhinitis or eczema 0.6 1.2 6.5 0.7 -0.4 -2.6 0.6 -1.7 -0.5 -0.5 0.2 -0.3
Multivitamins +/- minerals 0.2 0.3 1.5 -0.6 0.3 0.3 -0.1 1.2 0.4 -0.4 0.4 0.0
Stomach or abdominal pain in last month 1.4 1.7 5.6 -0.3 1.9 0.9 1.3 0.3 2.4 1.1 1.1 1.2
Supplements: Glucosamine 0.6 0.7 3.0 -0.8 -0.7 0.2 -1.7 1.0 -0.7 -0.0 0.1 -0.9
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.8 0.3 1.1 -0.2 -0.1 -0.7 1.5 1.7 1.2 0.7
Medication: Atenolol 0.4 0.5 2.1 -1.4 -0.5 0.5 -0.9 -0.1 -0.5 -0.4 0.5 -0.8
Medication: Levothyroxine sodium 0.4 0.8 2.5 -0.5 0.0 0.4 0.5 1.5 -0.6 -1.0 -1.6 -0.3
Sitting height 0.1 1.0 3.1 0.3 -0.4 -1.2 0.8 0.6 -0.9 -1.8 -1.4 -0.5
Chronic bronchitis/emphysema (father) 0.4 0.5 2.1 0.3 -0.0 -0.3 0.1 -1.4 0.0 0.3 1.4 -0.4
High blood pressure (mother) 0.2 0.3 0.7 -0.1 -0.7 0.0 -0.1 -0.4 -0.6 -0.8 -0.6 -0.5
Body mass index (BMI) 1.7 7.2 14.4 2.3 3.8 -1.9 3.3 -1.6 3.6 1.4 0.9 3.4
Impedance of leg (left) 0.6 3.0 8.3 -1.4 -2.9 0.6 -1.8 1.0 -2.3 -0.3 -0.2 -2.5
Leg predicted mass (left) 0.8 4.1 9.5 1.9 3.1 -1.3 2.9 -0.4 2.2 -0.1 -0.5 2.8
Trunk fat mass 1.4 6.1 11.9 2.5 3.5 -2.0 3.2 -0.6 3.2 1.0 0.3 3.3
Waist circumference 1.4 5.3 11.3 2.2 3.4 -1.1 3.3 -0.5 3.0 0.5 0.2 3.1
Number of incorrect matches in round 1.4 2.3 4.7 1.0 1.4 1.0 1.9 1.3 1.5 -2.0 -2.2 0.7
Past tobacco smoking 1.0 1.8 6.9 1.1 -1.1 0.1 -0.3 0.3 -2.0 -1.7 -2.6 -0.4
Alcohol usually taken with meals 2.4 3.8 10.0 1.1 -2.0 -3.2 -1.6 -2.5 -2.4 1.0 1.7 -0.8
Nervous feelings 2.5 4.6 11.4 -1.2 -3.4 0.5 -1.6 0.5 -3.4 -2.0 -1.3 -3.0
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 3.3 -0.8 0.2 1.6 0.6 0.9 0.3 -1.8 -1.8 -0.3
Hearing difficulty/problems with background noise 0.5 0.8 2.1 -1.0 -1.0 -0.7 -1.1 -0.3 -1.5 -0.0 0.3 -1.1
Hair/balding pattern: Pattern 2 0.2 0.3 0.8 0.1 0.7 -0.4 -0.5 -0.2 -0.8 -0.1 -0.6 0.9
Had menopause 0.4 0.6 1.1 -0.6 -0.8 -1.0 -0.5 -0.7 -0.9 -0.6 0.1 -1.0
Had other major operations 1.9 2.3 5.8 2.3 0.3 -2.4 1.5 -1.7 0.6 0.7 1.6 0.9
Forced vital capacity (FVC) 0.1 0.5 1.8 -0.2 0.1 -0.4 -1.1 0.2 -0.4 1.0 1.4 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.4 -0.5 -0.6 -1.2 -0.5 0.2 -0.2 0.2 0.7 -0.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.4 0.7 0.8 0.7 -0.0 -0.3 0.8 1.1 1.2 1.1
Qualifications: None of the above 0.7 1.6 5.7 -2.4 -0.4 1.5 -0.7 1.4 -0.3 -1.0 -1.3 -1.0
Financial difficulties in last 2 years 1.4 1.9 4.8 0.8 2.0 1.7 0.6 1.0 2.2 0.7 -0.2 1.4
Mouth/teeth dental problems 0.6 0.9 1.5 -0.8 -1.2 0.3 -1.1 1.1 -1.2 -0.6 -0.8 -0.9
Heart attack 0.6 0.7 1.7 -0.2 -1.3 -1.3 -0.6 -0.7 -0.8 -0.6 0.4 -1.0
Allergy 0.5 1.2 7.3 -0.3 -0.1 2.7 -0.7 1.3 -0.0 0.3 -1.0 0.3
Pain all over the body in last month 0.6 0.6 3.4 0.2 -0.1 -1.1 0.4 -0.5 0.3 0.5 1.8 0.3
Diabetes (self-reported) 3.1 4.8 11.6 3.4 2.4 -1.6 3.1 -1.5 2.2 -0.2 -0.2 2.5
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.6 -1.5 -1.7 -1.0 -0.7 -0.9 -1.9 0.0 -0.2 -1.5
Medication: Ramipril 0.8 1.0 3.2 0.4 0.6 -1.8 -0.2 -1.7 0.9 0.7 1.0 0.5
Medication: Simvastatin 2.0 2.9 6.0 2.1 2.3 -0.8 2.4 0.1 2.5 -0.3 0.7 2.0
Fluid intelligence score 0.2 0.5 0.9 0.9 0.8 0.6 0.7 0.4 0.3 -0.8 -0.6 0.9
Illnesses of siblings 2.6 3.6 8.9 -1.8 -1.3 1.6 -1.4 2.6 -1.9 -1.9 -3.0 -1.0
Neuroticism score 0.4 0.7 2.0 0.2 -0.8 1.0 -0.1 1.2 -0.7 -1.4 -0.8 -0.6
Weight 1.4 6.9 14.6 2.5 3.8 -2.2 3.3 -1.3 3.2 0.9 0.4 3.5
Impedance of arm (right) 0.8 3.9 5.8 -2.1 -2.2 2.3 -2.2 2.4 -2.0 -0.6 -0.5 -2.1
Arm fat percentage (right) 1.2 4.6 10.6 1.8 3.2 -1.2 2.9 -0.7 2.9 1.0 0.4 2.8
Trunk fat-free mass 0.4 2.4 5.5 1.2 2.1 -1.7 2.3 -1.3 1.1 -0.7 -0.8 1.7
Hip circumference 1.0 4.3 11.5 1.3 3.4 -1.5 2.4 -0.7 2.9 0.9 0.3 2.8
Time employed in main current job 0.2 0.2 0.8 0.4 -0.3 -0.9 -0.2 -0.3 -0.5 -0.2 0.3 -0.0
Alcohol intake versus 10 years previously 1.5 2.2 6.3 0.9 1.8 0.6 2.5 0.5 1.5 -1.4 -1.8 1.1
Father’s age at death 2.4 3.3 5.3 -2.0 -1.8 1.5 -2.2 1.3 -2.3 -1.8 -1.6 -1.6
Worrier / anxious feelings 1.8 3.4 7.5 -1.0 -2.7 1.3 -2.2 1.7 -2.3 -0.9 -1.0 -2.4
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 7.6 1.4 2.7 0.9 2.8 0.4 2.5 -0.5 -1.9 2.1
Falls in the last year 1.1 1.6 3.1 -0.0 1.7 1.0 1.5 1.2 1.8 0.3 -0.4 1.7
Hair/balding pattern: Pattern 3 1.4 2.1 5.6 0.2 1.2 -0.0 1.2 -1.4 2.4 2.1 2.0 0.5
Number of live births 0.8 1.2 4.2 -0.9 -1.2 -0.4 -2.1 -0.7 -1.6 0.3 -0.5 -0.7
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.8 1.2 0.9 -1.2 0.0 -0.7 0.1 1.0 1.0 1.3
Pulse rate 1.5 2.5 4.6 1.5 1.4 0.1 2.1 -0.3 2.1 1.6 1.9 1.6
Happiness 0.2 0.3 0.7 0.0 0.7 0.9 0.4 -0.3 0.7 0.1 0.0 0.5
Noisy workplace 0.4 0.5 2.1 -0.8 -0.6 1.4 0.3 0.8 -0.1 0.5 -0.3 -0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.1 1.1 0.3 -1.0 1.1 -1.0 -0.8 0.3 0.8 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.2 -1.1 -0.7 1.5 -0.8 1.1 -1.0 -0.5 -0.5 -1.5
Mouth/teeth dental problems: Dentures 0.3 0.6 1.5 -1.2 -0.5 1.1 -0.4 1.2 0.2 0.0 -0.1 -0.7
Asthma 0.3 0.6 1.3 -1.1 -1.1 -0.7 -0.7 -0.1 -0.7 -0.2 0.6 -1.2
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 6.2 2.1 2.0 -1.2 1.6 -0.8 1.2 0.6 -0.3 2.5
Medication: Cholesterol lowering 0.3 0.5 2.0 0.1 0.1 0.7 1.4 0.5 0.5 -1.1 -0.4 -0.4
Depression (self-reported) 1.2 1.5 5.5 0.0 0.2 1.2 0.9 1.5 0.7 -2.4 -1.7 0.2
Medication: Lansoprazole 1.0 1.2 3.5 -1.4 -1.1 1.9 -0.6 1.1 -0.4 -0.7 0.5 -1.2
Prospective memory result 0.7 0.9 2.3 0.8 1.2 0.0 -0.1 0.1 1.5 1.1 0.3 1.5
Lung cancer (father) 1.2 1.4 5.9 0.7 0.6 -0.8 0.5 -1.1 0.7 1.4 2.4 1.1
Illnesses of mother 0.2 0.2 0.9 0.2 0.4 0.3 0.5 -0.6 -0.5 0.1 -0.9 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 6.7 2.6 1.9 -2.2 0.5 -1.2 1.1 1.1 1.3 2.4
Pulse wave Arterial Stiffness index 1.2 1.3 2.7 -0.7 -1.3 -1.1 -1.2 -1.2 -0.8 1.4 1.6 -0.9
Impedance of arm (left) 0.9 4.2 8.3 -1.5 -2.5 1.9 -2.2 2.9 -2.4 -1.0 -0.9 -2.1
Arm fat mass (right) 1.4 5.7 12.6 2.1 3.5 -1.6 3.2 -1.0 3.1 0.9 0.4 3.1
Trunk predicted mass 0.4 2.3 5.4 1.2 2.1 -1.6 2.3 -1.3 1.1 -0.7 -0.9 1.7
Standing height 0.1 0.6 1.8 0.4 0.1 -1.1 0.5 0.4 -0.8 -1.4 -1.1 0.2
Length of working week for main job 0.7 0.8 2.1 -1.5 -0.9 1.3 -0.8 0.1 -0.3 0.3 0.1 -1.3
Exposure to tobacco smoke at home 1.1 1.2 2.6 1.3 0.8 0.0 1.6 -1.3 1.1 -0.8 -1.4 0.4
Breastfed as a baby 0.4 0.5 1.6 -0.9 -1.0 -0.2 -0.8 -0.0 -0.6 -0.6 -0.2 -1.3
Tense / ‘highly strung’ 0.4 0.7 2.0 -0.0 -1.2 0.4 0.2 -0.5 -0.8 -1.4 -0.6 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.8 -0.4 -0.2 0.3 0.0 -0.1 0.7 0.9 0.7 -0.7
Hair/balding pattern: Pattern 4 0.9 2.2 8.9 -0.9 -2.1 -0.1 -3.0 0.0 -1.6 -0.0 0.5 -1.6
Birth weight of first child 0.3 0.6 3.8 0.7 0.1 -1.9 0.6 -0.8 -0.1 0.2 0.5 0.2
Peak expiratory flow (PEF) 1.0 2.3 5.5 2.2 1.4 -2.4 1.2 -1.8 0.7 0.7 0.6 1.7
Pulse wave reflection index 1.5 1.8 4.2 -1.6 -1.7 -0.7 -2.1 -0.6 -1.9 0.5 -0.0 -1.5
Ever highly irritable/argumentative for 2 days 0.4 0.4 2.6 -0.4 -0.2 0.5 -0.1 0.5 0.1 0.7 1.6 -0.0
Loud music exposure frequency 1.4 1.5 2.5 1.1 1.5 -1.3 1.2 -1.0 1.3 0.6 1.3 1.6
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 7.2 2.2 1.4 -0.8 2.7 -0.9 0.8 0.4 0.6 1.2
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 4.6 1.1 1.8 -0.8 2.1 -2.1 1.8 0.9 0.7 1.2
Blood clot in the leg (DVT) 0.4 0.5 1.5 0.5 0.9 -0.1 1.2 0.4 0.7 -1.1 0.6 0.4
Medication: Paracetamol 0.6 0.9 2.5 0.1 1.5 0.2 0.5 0.2 1.6 1.1 0.7 1.2
Headache pain in last month 0.4 0.7 1.4 0.2 -1.0 0.0 -0.5 -0.5 -0.9 1.1 1.2 -0.9
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.7 0.4 0.6 0.3 -0.3 0.1 -0.0 0.0 -0.6 0.8
Glaucoma (self-reported) 2.6 3.0 7.1 1.3 1.3 -2.7 0.9 -2.5 1.2 1.3 1.8 1.8
Gout (self-reported) 0.1 0.2 0.9 0.1 0.3 0.0 0.3 0.9 0.3 0.0 -0.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 2.0 -0.5 0.6 0.4 0.6 1.4 0.2 -0.0 -0.1 0.1
Medication: Amlodipine 2.0 2.9 5.0 1.7 2.2 -1.5 2.2 -0.8 1.9 0.8 1.0 2.2
Medication: Ventolin 100micrograms inhaler 1.9 2.4 8.0 -1.6 -1.3 1.4 -0.7 2.8 -1.3 -1.3 -0.7 -1.7
Birth weight 0.2 0.5 1.6 -1.0 -0.3 -0.6 -1.1 0.1 0.3 1.2 0.6 -0.2
Chronic bronchitis/emphysema (mother) 2.0 2.3 7.1 -1.1 -1.5 2.0 -1.0 2.7 -0.6 0.5 1.7 -1.4
High blood pressure (siblings) 1.3 1.8 6.7 0.6 0.2 -1.0 -0.3 -1.8 0.6 2.2 2.6 0.1
Forced vital capacity (FVC), Best measure 0.3 1.0 1.8 1.4 1.0 -1.3 -0.3 -0.3 0.4 0.7 1.2 1.3
Body fat percentage 1.2 4.6 9.1 2.0 2.9 -1.5 2.6 -0.5 3.0 1.4 0.6 2.8
Leg fat percentage (right) 1.6 5.7 12.0 2.2 3.1 -1.6 2.9 -1.5 3.5 1.4 0.6 2.9
Arm fat-free mass (right) 0.8 4.1 8.1 2.1 2.7 -2.4 2.9 -1.4 1.8 -0.2 -0.3 2.5
Exposure to tobacco smoke outside home 1.1 1.5 3.6 0.8 1.2 0.7 1.9 -0.5 1.6 -1.5 -1.5 0.4
Comparative body size at age 10 0.9 2.5 4.9 1.6 1.9 -1.5 1.8 -2.2 1.6 0.9 0.2 1.6
Number of full brothers 0.2 0.2 0.7 -0.5 0.7 0.2 0.2 0.4 0.9 -0.2 -0.2 -0.1
Worry too long after embarrassment 1.3 2.2 4.9 -1.0 -2.1 0.2 -1.5 0.4 -2.2 -1.5 -0.6 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.6 0.2 1.3 1.1 0.7 1.3 1.6 0.2 -0.3 0.4
Wheeze or whistling in the chest in last year 1.2 2.2 4.7 -1.6 -1.4 0.8 0.4 1.3 -1.6 -2.1 -0.8 -2.2
Number of children fathered 1.4 1.6 5.3 0.6 0.4 1.0 -1.1 0.3 1.4 2.3 2.0 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.1 -0.1 0.0 -0.3 -0.4 -0.3 0.5 0.5 1.1 -0.3
Age at first live birth 1.2 2.1 6.3 0.1 -1.5 -0.0 -0.5 1.3 -1.4 -2.1 -2.5 -1.1
Pulse wave peak to peak time 1.1 1.3 2.9 0.4 1.1 1.0 1.0 1.4 0.7 -1.4 -1.7 0.7
Health satisfaction 1.5 1.9 4.7 1.1 2.2 -0.1 1.9 -0.3 2.2 -0.2 0.1 1.6
Shortness of breath walking on level ground 4.7 5.5 11.8 2.4 3.4 -0.4 3.3 0.8 3.4 0.5 -0.2 2.9
Qualifications: College or University degree 0.2 0.7 2.2 0.4 -0.9 -0.4 -0.6 -0.4 -1.3 -0.8 -1.5 -0.2
Eye problems/disorders: None of the above 0.2 0.2 0.8 -0.0 0.1 0.6 0.3 -0.3 -0.1 -0.3 -0.9 -0.3
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.5 -0.3 -0.4 -1.0 -0.2 -1.2 -0.5 -0.0 0.2 -0.6
Emphysema/chronic bronchitis 0.6 0.7 2.3 -1.1 0.1 0.7 -0.1 0.0 0.3 1.2 1.5 -0.6
Medication for pain relief, constipation, heartburn 0.8 1.3 3.2 -0.9 -1.4 1.1 -1.8 0.9 -1.4 -0.4 0.2 -1.2
Neck or shoulder pain in last month 1.4 1.9 3.6 1.0 1.7 -1.7 0.8 -1.4 1.9 1.4 0.9 1.3
Medication: Blood pressure 1.0 1.7 7.3 -0.6 -0.6 -1.8 -0.8 -0.6 -0.0 1.7 2.7 -0.7
Angina (self-reported) 0.6 0.8 3.3 0.9 0.7 -0.7 1.8 -0.6 1.0 -0.4 0.1 0.3
Migraine (self-reported) 1.0 1.2 4.9 0.7 0.0 -1.1 0.0 -1.2 0.0 1.8 2.2 0.1
Medication: Ibuprofen 2.6 3.1 7.3 2.2 2.2 -1.1 1.7 -1.3 1.8 1.1 0.4 2.7
Medication: Allopurinol 0.4 0.6 1.7 -0.3 0.3 0.0 0.6 1.3 0.3 -1.2 -0.9 0.5
Medication: Omeprazole 0.3 0.4 0.9 0.4 0.4 -0.9 1.0 -0.3 0.7 -0.1 0.7 -0.0
Medication: Seretide 50 evohaler 2.0 2.3 6.2 -1.3 -2.5 0.6 -0.9 1.1 -2.2 -0.9 -0.5 -2.2
Mean time to correctly identify matches 1.3 2.5 5.9 -0.9 -1.6 -0.9 -2.0 -1.3 -1.3 1.3 2.4 -1.9
Heart disease (mother) 0.7 0.9 3.7 -0.7 0.3 0.4 -0.3 -0.7 0.9 1.3 1.9 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 2.9 -0.9 -1.2 -0.8 -1.7 -0.1 -1.3 1.1 1.7 -1.0
Whole body fat mass 1.1 4.7 9.6 1.9 3.1 -1.5 2.7 -0.6 3.0 1.0 0.4 2.9
Leg fat mass (right) 1.4 5.6 11.0 2.1 3.3 -1.7 2.9 -1.2 3.3 1.2 0.5 3.1
Arm predicted mass (right) 0.7 3.5 6.9 1.9 2.5 -2.2 2.6 -1.3 1.6 -0.3 -0.5 2.2
Pulse rate, automated reading 1.3 4.3 10.6 1.5 1.6 -1.9 1.9 -2.1 1.9 2.4 3.3 1.6
Alcohol intake frequency. 1.2 2.7 5.8 1.6 2.2 -1.0 2.0 0.2 2.1 1.0 0.9 2.4
Comparative height size at age 10 0.3 1.5 5.3 -1.0 0.3 -2.3 -0.7 -0.7 0.7 0.9 2.3 0.1
Number of full sisters 1.7 2.1 8.5 0.5 0.7 0.4 0.6 0.7 1.4 2.9 2.4 0.7
Suffer from ‘nerves’ 0.3 0.5 1.3 -0.1 -0.6 -0.6 -0.7 -1.1 -0.4 -0.8 -0.7 -0.7
Overall health rating 2.1 4.4 13.2 1.8 3.3 -0.2 2.4 -0.1 3.6 0.8 0.2 2.5
Chest pain or discomfort 3.1 4.5 9.1 3.0 2.8 -0.8 2.8 -0.5 2.8 0.6 0.5 2.5
Had major operations 0.3 0.4 1.0 -0.0 -0.1 0.9 0.8 1.0 0.6 -0.5 -0.3 0.1
Age at last live birth 1.3 1.9 6.0 -0.8 -1.0 1.0 -0.3 1.4 -1.4 -1.8 -2.5 -1.0
Family relationship satisfaction 1.2 1.5 3.2 1.2 1.8 0.2 1.0 1.1 1.3 0.5 1.5 1.4
Leg pain on walking 1.3 1.7 3.0 1.3 1.6 1.4 1.7 0.2 1.7 0.2 -0.6 1.6
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 3.6 1.0 1.3 0.0 1.9 0.8 1.5 1.1 1.1 1.0
Commuting to job workplace: Car/motor vehicle 1.3 1.5 4.0 -0.9 -1.8 -0.6 -1.6 -1.1 -2.0 -0.2 -0.4 -1.2
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 4.3 0.7 -1.1 -1.9 -1.1 -2.1 -0.9 -0.5 0.2 -0.5
Medication: Aspirin 0.2 0.3 0.7 0.4 -0.2 -0.9 0.4 -0.3 0.8 0.6 0.3 -0.1
Supplements: Vitamin C 0.5 0.6 1.4 0.6 1.2 0.4 0.5 0.9 1.0 -0.5 -0.6 0.8
Knee pain experienced in last month 0.4 0.7 1.9 -0.3 1.4 0.6 0.4 -0.4 1.1 -0.6 -1.3 0.7
Hypertension (Self-reported) 1.2 3.3 5.4 1.7 2.0 -1.7 1.4 -2.1 2.3 1.2 2.1 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.5 13.1 -0.3 0.2 0.3 -0.1 -1.7 0.9 2.4 3.6 -0.3
Illnesses of father: Heart disease 2.1 2.9 8.2 2.0 1.2 -2.6 0.3 -2.9 1.2 1.3 1.0 1.3
Illnesses of siblings: Diabetes 1.5 1.9 5.2 1.2 1.6 -0.2 1.8 -2.3 1.8 -0.2 0.5 0.9
Smoking status: Previous 1.4 2.1 7.0 -0.5 1.1 -1.5 0.6 -1.7 1.6 1.4 2.6 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 3.6 0.9 1.9 0.9 1.7 1.7 1.6 -0.9 -1.3 1.7
Whole body fat-free mass 0.6 3.4 7.3 1.7 2.7 -1.8 2.7 -1.1 1.8 -0.2 -0.5 2.4
Leg fat-free mass (right) 0.7 4.0 9.1 2.1 3.0 -1.6 2.7 -0.3 2.1 0.2 -0.2 2.9
Arm fat percentage (left) 1.1 4.6 10.1 2.0 3.2 -1.2 2.9 -0.5 2.8 0.8 0.2 2.9
Average weekly red wine intake 0.4 0.5 2.0 0.8 -0.2 -0.8 0.8 -1.4 -0.1 0.0 0.9 -0.2
Handedness (chirality/laterality): Left-handed 0.5 0.5 1.3 0.3 0.4 -1.1 -0.4 -1.0 0.7 0.8 1.1 0.4
Mood swings 0.3 0.6 1.2 0.7 0.9 0.9 0.7 0.8 1.1 -0.4 -0.5 0.6
Loneliness, isolation 0.9 1.3 3.5 -1.0 -0.5 0.9 1.3 0.5 -0.3 -1.9 -1.5 -1.1
Long-standing illness, disability or infirmity 0.9 1.4 4.4 0.4 2.1 -0.1 1.1 0.9 1.9 -0.3 0.5 1.3
Ever had bowel cancer screening 0.7 0.9 1.9 -1.1 -1.3 0.7 -0.6 -0.6 -0.6 0.1 1.1 -1.4
Diabetes diagnosed by doctor 4.3 7.1 16.2 3.9 3.1 -1.4 4.0 -1.7 2.7 0.2 -0.1 3.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.9 1.2 0.2 -1.7 0.5 -0.2 0.1 0.7 0.6 0.8
Friendships satisfaction 0.3 0.3 1.1 0.1 0.1 0.8 -0.1 1.1 0.2 0.6 0.8 0.2
Qualifications: nursing, teaching 0.2 0.3 0.9 0.1 0.0 -0.3 -0.6 -0.3 -0.1 1.0 0.9 0.1
Commuting to job workplace: Walk 2.9 3.2 10.2 1.1 2.7 -0.6 1.7 -0.4 3.2 1.3 0.5 2.2
Eye problems/disorders: Cataract 0.9 1.1 2.3 0.7 1.5 -0.5 0.5 1.4 1.3 -0.5 -0.1 1.5
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.8 1.3 1.2 -1.2 1.0 -1.4 0.8 0.8 1.7 1.1
Medication for cholesterol 1.4 2.1 5.2 -1.9 -1.0 1.5 -1.8 2.3 -1.4 -0.2 -0.5 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.1 -0.9 0.6 0.5 1.1 0.8 0.3 -1.4 -0.2 -0.1
Back pain experienced in last month 0.7 1.0 3.7 -0.2 1.1 0.4 1.2 -0.4 1.9 0.4 1.5 0.2
Mineral and other dietary supplements 1.8 2.5 5.4 0.9 2.3 -0.4 1.7 -1.1 2.1 1.2 1.3 2.1
Breast cancer (self-reported) 0.2 0.2 1.5 0.0 0.3 -1.2 -0.4 -0.4 0.3 0.1 0.4 -0.0
Asthma (self-reported) 0.2 0.5 1.1 -1.0 -1.0 -0.6 -0.6 -0.2 -0.5 0.0 0.6 -1.0
Osteoporosis (self-reported) 2.2 2.7 7.0 -2.6 -1.4 1.2 -2.2 1.8 -0.7 0.4 -0.1 -2.3
Osteoarthritis (self-reported) 0.5 0.7 1.7 0.6 1.0 -0.1 1.3 -0.2 1.2 0.1 -1.1 0.8
Medication: Aspirin 0.2 0.3 0.9 0.1 -0.7 -1.0 0.0 -0.6 0.2 0.6 0.6 -0.6
Medication: Gliclazide 3.0 3.4 9.6 2.0 2.0 0.6 3.1 -1.7 1.9 -1.1 -1.6 1.3
Illnesses of father: None of the above (group 1) 1.4 1.7 4.9 -0.9 -0.7 2.2 0.4 2.2 -0.4 -1.3 -1.4 -0.9
Smoking status: Current 1.9 3.0 11.0 -2.3 -0.7 3.3 -0.8 2.7 -0.0 0.4 -0.4 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.7 10.2 2.7 2.0 -3.2 1.0 -1.0 1.5 0.5 1.2 2.3
Whole body water mass 0.6 3.4 7.4 1.7 2.7 -1.8 2.7 -1.0 1.7 -0.4 -0.6 2.4
Leg predicted mass (right) 0.7 3.8 8.8 2.0 3.0 -1.5 2.6 -0.3 2.0 0.2 -0.3 2.8
Arm fat mass (left) 1.2 4.9 11.1 1.9 3.3 -1.6 3.1 -0.7 2.9 0.7 0.2 2.9
Number of self-reported non-cancer illnesses 1.2 2.1 6.1 0.9 2.0 -0.6 2.2 -0.8 2.5 0.1 0.5 1.3
Average weekly champagne plus white wine intake 1.5 2.1 3.9 2.0 1.6 -1.2 1.7 -1.2 1.4 -1.2 -0.4 1.8
Miserableness 0.3 0.5 1.6 0.3 0.6 1.2 0.4 0.8 1.0 0.4 0.5 0.5
Guilty feelings 0.3 0.4 0.8 0.6 0.8 0.5 0.5 0.5 0.9 -0.1 0.5 0.9
Wears glasses or contact lenses 2.0 2.3 3.9 0.8 1.9 -0.8 0.0 -1.2 1.8 2.0 2.0 1.9
Ever taken oral contraceptive pill 1.0 1.1 4.8 0.1 0.9 -0.0 -0.6 -0.2 1.1 2.2 1.6 0.5
Hearing aid user 0.7 0.8 3.6 1.5 -0.0 -1.9 0.2 0.2 0.7 -0.2 0.8 0.2
Mother’s age at death 0.1 0.2 0.6 0.6 0.0 0.8 0.0 0.5 -0.2 -0.2 -0.3 0.5
Financial situation satisfaction 1.1 1.4 3.9 0.6 1.9 0.0 -0.0 0.3 1.8 1.3 0.3 2.0
Tinnitus: Yes, now most or all of the time 1.0 1.2 5.7 -0.5 0.5 -0.4 -0.8 0.2 1.0 1.4 2.4 0.7
Commuting to job workplace: Public transport 0.3 0.3 0.7 0.2 0.7 0.6 0.8 -0.2 0.8 0.3 0.6 0.4
Eye problems/disorders: Glaucoma 1.1 1.3 2.6 1.1 0.8 -1.6 0.4 -1.5 1.0 1.0 0.7 1.5
Medication: Blood pressure 1.4 2.8 6.0 2.0 1.6 -1.8 2.0 -2.5 1.6 0.0 0.7 1.5
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.7 0.8 1.1 -0.0 0.3 0.7 1.6 0.1 -0.7 1.0
Supplements: Fish oil (including cod liver oil) 1.4 1.9 4.1 -0.9 -2.0 0.8 -2.0 1.7 -1.5 -0.1 -0.5 -1.4
High cholesterol (Self-reported) 1.1 1.9 5.0 1.6 1.6 -0.3 2.1 -1.0 2.2 -0.1 0.6 1.2
Medication: Bendroflumethiazide 0.7 1.1 1.9 -1.1 -1.0 -0.8 -1.4 -1.0 -0.1 1.4 1.2 -1.0
Medication: Paracetamol 0.5 0.8 2.0 0.0 1.2 0.4 0.6 -0.4 1.4 1.0 0.9 1.0
Medication: Lisinopril 0.7 0.9 2.8 -1.3 -0.6 0.7 -1.7 1.2 -0.3 1.1 0.4 -0.5
Medication: Atorvastatin 0.3 0.3 1.6 0.5 -0.4 -0.0 0.7 -1.3 0.1 0.4 -0.4 -0.3
Illnesses of father: High blood pressure 0.2 0.2 0.9 -0.4 0.4 -0.1 -0.9 -0.6 0.4 0.3 -0.4 0.2
Alcohol drinker status: Never 1.2 1.4 4.5 -0.1 0.2 1.5 0.4 1.4 0.1 -1.8 -2.1 -0.3
Ever smoked 0.7 1.3 2.6 -1.5 0.2 1.6 -0.3 0.9 1.2 1.4 1.6 -0.2
Basal metabolic rate 0.7 4.0 8.8 1.8 3.0 -1.9 2.9 -1.0 2.0 -0.1 -0.5 2.6
Leg fat percentage (left) 1.7 6.3 12.7 2.4 3.2 -1.9 3.0 -1.6 3.6 1.8 0.9 3.0
Arm fat-free mass (left) 0.6 3.2 6.4 1.6 2.5 -2.0 2.3 -1.5 1.8 0.2 0.0 2.2
Number of operations (self-reported) 0.4 0.6 2.4 0.8 -0.6 -0.7 0.8 -0.5 -0.0 0.1 1.5 -0.6
Average weekly beer plus cider intake 3.4 5.0 11.4 2.2 3.2 -0.3 3.4 -0.6 3.0 -0.9 -0.5 2.8
Irritability 0.8 1.4 5.0 0.2 0.5 0.7 0.7 2.2 0.4 -2.1 -1.3 0.4
Risk taking 1.0 1.4 3.6 1.0 1.9 -0.9 1.6 -0.5 1.6 0.2 -0.5 1.3
Ever had prostate specific antigen (PSA) test 2.7 3.1 9.9 0.1 -1.8 -2.5 -1.8 -3.1 -1.4 0.7 1.4 -1.1
Fractured/broken bones in last 5 years 0.9 1.2 3.8 1.4 1.3 -0.3 2.0 0.9 1.0 -0.6 0.0 1.0
Age started oral contraceptive pill 2.9 3.7 9.7 -1.3 -2.7 0.6 -2.2 0.3 -3.1 -1.6 -0.6 -2.5
Diastolic blood pressure, automated reading 0.5 1.5 4.3 -0.9 -1.8 -0.6 -0.8 -0.7 -2.1 0.2 0.4 -1.8
Ever depressed for a whole week 0.6 0.8 1.5 0.9 0.8 -0.0 0.2 -0.9 1.0 1.2 1.1 1.1
Unable to work because of sickness or disability 1.8 2.3 5.6 1.0 2.4 -0.6 1.9 -0.9 2.3 0.2 1.0 1.6
Commuting to job workplace: Cycle 1.0 1.3 3.9 -0.3 0.5 0.7 1.6 0.7 0.6 -2.0 -1.8 -0.1
Myopia 0.5 0.7 2.3 0.2 -0.3 -1.3 -0.7 -0.4 -0.5 1.5 1.0 0.5
Vascular/heart problems diagnosed by doctor 1.5 4.1 7.1 -2.0 -1.7 2.0 -1.4 2.4 -2.3 -1.7 -2.7 -1.5
Cholesterol lowering medication 4.4 6.4 9.1 3.0 2.6 -2.7 2.4 -2.5 2.8 1.7 2.0 2.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.5 -0.3 -0.2 -1.1 0.7 -1.0 0.2 -0.3 1.2 -0.8
Pain experienced in last month 0.6 0.9 2.8 -0.4 -0.9 0.3 -0.2 1.0 -1.2 -1.7 -1.2 -0.6
Supplements: Calcium 1.4 1.6 4.0 -1.7 -1.2 1.2 -2.0 0.2 -0.9 0.0 0.8 -1.8
Basal cell carcinoma (self-reported) 0.5 0.5 2.6 -1.1 0.5 1.6 0.2 0.5 0.6 -0.3 0.1 -0.4
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.1 -0.3 -1.5 -1.2 -0.7 -0.8 -0.9 -0.7 0.5 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.4 0.5 1.1 -0.3 1.2 0.4 0.7 -1.1 0.4 0.6
Heart disease (siblings) 1.6 2.0 4.2 1.1 1.3 -2.1 2.0 -1.5 1.6 0.2 1.0 0.9
Alcohol drinker status: Previous 2.9 3.3 6.9 1.6 2.5 -0.1 2.2 -0.6 2.6 0.6 1.7 2.3
Pack years of smoking 0.9 1.3 6.5 0.2 0.4 1.1 0.7 1.0 0.5 -1.3 -2.5 0.4
Impedance of whole body 0.5 2.5 5.4 -1.0 -2.3 1.2 -1.8 1.9 -2.0 -0.4 -0.3 -1.9
Leg fat mass (left) 1.5 5.9 11.5 2.3 3.4 -1.9 3.0 -1.2 3.4 1.2 0.5 3.2
Arm predicted mass (left) 0.8 3.8 7.6 1.9 2.8 -2.2 2.5 -1.4 2.0 0.3 0.1 2.5