TWAS hub - SMURF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.114	0.043	0.00051	0.019	0.032	0.019	0.032	0.015	2.1e-03	7.5e-05	0.0022	8.5e-05	5.1e-03
2	GTEx	Esophagus Mucosa	0.127	0.050	0.00400	0.102	NA	0.039	NA	0.095	2.7e-07	NA	0.0012	NA	7.0e-07
3	TCGA	Thyroid Carcinoma	0.048	0.026	0.00630	0.005	0.000	0.007	NA	0.005	9.7e-02	3.6e-01	0.0680	NA	8.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Irritable Bowel Disease (IBD)	4.6	10.9	25.5	-5.0	2.6	-0.5
Hayfever/allergic rhinitis (self-reported)	4.6	6.0	14.4	1.3	-3.8	-1.4
Unable to work because of sickness or disability	3.3	4.2	9.7	-3.1	1.4	-1.1
Crohns Disease (2017)	3.2	7.1	16.4	-4.0	2.1	-0.6
Ulcerative Colitis (UC)	3.2	6.0	14.9	-3.9	1.8	-0.2
Wheeze or whistling in the chest in last year	3.2	5.6	8.2	-2.7	1.2	-2.9
Pulse rate, automated reading	3.0	9.6	21.6	1.2	4.7	-2.4
Myopia	3.0	4.3	8.0	2.0	-2.8	-0.9
Blood Red Count	2.9	27.6	50.4	-1.4	-5.5	7.1
Multivitamins +/- minerals	2.7	3.5	7.0	1.4	-2.6	1.2
Alcohol intake frequency.	2.7	6.3	13.8	-3.7	-0.5	2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	6.2	2.5	-0.1	-1.3
Ulcerative Colitis	2.3	3.4	8.2	-2.9	1.4	0.0
Respiratory disease	2.3	5.1	7.6	-2.8	0.3	-2.8
Type 2 Diabetes (T2D) (2012)	2.2	2.6	7.3	-0.6	-2.7	0.0
Hayfever, allergic rhinitis or eczema	2.2	4.7	7.6	0.0	-2.8	-2.5
Birth weight	2.2	4.7	7.3	2.7	0.5	-2.6
Mouth/teeth dental problems: Loose teeth	2.2	2.6	6.0	-1.2	2.4	-0.6
Medication: Seretide 50 evohaler	2.2	2.5	3.6	1.9	1.3	-1.5
Townsend deprivation index at recruitment	2.1	2.9	7.2	-2.7	1.2	-0.0
Noisy workplace	2.1	2.6	4.7	-1.1	2.2	-1.4
Alcohol drinker status: Previous	2.1	2.4	6.5	-0.9	-0.0	2.6
Medication: Lansoprazole	2.0	2.2	6.5	-0.2	-0.4	-2.6
Alcohol drinker status: Never	1.9	2.3	3.0	-1.2	-1.7	1.6
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	2.9	1.7	-1.6	-1.0
Pulse rate	1.8	3.1	5.7	0.8	1.7	-2.4
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.4	-0.1	2.3	-1.2
Prostate Cancer	1.7	2.4	5.1	-0.0	1.4	-2.3
Hand grip strength (left)	1.7	4.5	10.5	3.2	-1.2	1.2
Vitamin and mineral supplements	1.7	2.4	4.8	0.8	2.2	-1.2
Supplements: Glucosamine	1.7	2.2	5.8	2.4	-0.2	-0.8
Mouth/teeth dental problems: Dentures	1.7	2.8	7.5	-2.7	-0.2	0.9
Overall health rating	1.7	3.6	5.9	-2.1	2.4	-0.7
Ever had prostate specific antigen (PSA) test	1.7	2.0	5.2	0.8	-2.3	0.4
Allergy	1.6	3.6	7.5	1.4	1.1	2.7
Neck or shoulder pain in last month	1.6	2.3	4.2	1.6	-0.2	-2.1
Heart disease (mother)	1.6	2.0	5.8	-0.1	2.4	-0.3
Knee pain experienced in last month	1.6	2.4	5.4	-1.1	0.8	-2.3
LDL Cholesterol	1.5	2.4	7.2	0.1	-2.7	0.0
Severe depression (siblings)	1.5	1.7	3.4	0.8	-1.1	1.8
Hand grip strength (right)	1.5	4.2	9.7	3.1	-1.6	0.5
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.2	-0.9	-2.1	0.9
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.3	-0.6	1.0	-2.1
Qualifications: CSEs or equivalent	1.4	1.8	4.4	-2.1	0.8	0.7
Chronic bronchitis/emphysema (father)	1.4	1.6	2.8	-1.4	-0.3	-1.7
Nervous feelings	1.4	2.6	6.9	-0.3	-0.9	2.6
Gout (self-reported)	1.4	1.9	3.5	-0.3	1.9	-1.5
Chest pain or discomfort	1.4	2.0	3.0	-1.1	1.7	-1.4
Ever had bowel cancer screening	1.4	1.6	2.8	1.7	0.6	-1.3
Mineral and other dietary supplements	1.4	1.8	4.4	-0.4	2.1	-1.0
Allergy or Eczema	1.3	3.3	5.5	-0.9	-2.3	-1.9
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.9	-0.5	-2.0	0.3
High blood pressure (mother)	1.3	1.8	3.5	1.4	-0.2	-1.9
Waist circumference	1.3	4.9	7.6	0.6	2.8	-2.6
Happiness	1.3	1.5	4.5	0.1	0.2	-2.1
Asthma	1.3	2.6	5.7	-2.4	1.1	-1.0
Length of working week for main job	1.3	1.5	3.3	1.0	0.1	-1.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.4	0.9	-1.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.9	-1.7	-1.2	0.2
Long-standing illness, disability or infirmity	1.3	2.0	5.8	-2.4	-0.4	-0.4
Hearing aid user	1.3	1.4	3.0	0.4	-1.7	1.1
Breast Cancer	1.2	2.9	8.4	2.9	0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.0	-0.3	2.0	-0.9
Mouth/teeth dental problems	1.2	1.8	4.4	2.1	-0.9	-0.5
Alcohol intake versus 10 years previously	1.2	1.8	2.5	-1.6	1.4	-0.9
Mean time to correctly identify matches	1.2	2.2	3.6	-1.7	1.9	0.4
Suffer from ‘nerves’	1.2	1.9	5.3	-0.5	-0.6	2.3
Leg pain on walking	1.2	1.5	4.3	-2.1	0.4	-0.3
Supplements: Vitamin C	1.2	1.4	3.1	-1.8	-0.2	1.0
Illnesses of siblings: Diabetes	1.2	1.5	2.5	-1.1	-0.9	-1.6
Crohns Disease (2012)	1.1	1.8	5.1	-2.3	0.4	0.0
Chronotype (morning person)	1.1	2.6	7.4	2.7	-0.6	0.3
Qualifications: A levels/AS levels or equivalent	1.1	2.4	6.5	2.5	-0.8	0.3
Number of children fathered	1.1	1.2	1.8	-1.3	0.8	1.1
Medication: Omeprazole	1.1	1.3	3.3	-1.8	0.6	0.4
Asthma (self-reported)	1.1	2.1	4.3	-2.1	0.9	-1.1
Medication: Atorvastatin	1.1	1.3	2.0	0.9	-1.4	-1.1
Number of operations (self-reported)	1.1	1.6	3.6	1.1	0.1	-1.9
Depression (Nagel 2018)	1.0	1.6	4.2	-0.7	2.1	0.0
Age at First Birth	1.0	1.4	2.3	1.4	-1.5	0.0
Rheumatoid Arthritis	1.0	1.3	2.5	0.9	-0.8	-1.6
Blood Eosinophil Count	1.0	7.4	21.0	-4.6	-0.5	-1.0
Medication for hormone replacement therapy	1.0	1.2	3.1	-1.8	0.6	-0.0
Hair/balding pattern: Pattern 2	1.0	1.3	3.2	0.9	-1.8	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.0	2.2	0.9	-1.0
Medication: Ramipril	1.0	1.2	2.9	0.2	1.7	-0.9
Illnesses of mother	1.0	1.2	2.0	1.2	-1.4	0.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.6	0.2	0.9	-1.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.4	1.1	-1.8	-0.2
Migraine (self-reported)	1.0	1.3	2.4	-0.9	-0.8	-1.5
Number of full sisters	1.0	1.3	2.2	-1.2	1.5	-0.2
Osteoarthritis (self-reported)	1.0	1.3	1.9	-0.9	1.0	-1.4
Wears glasses or contact lenses	1.0	1.2	1.4	1.2	-1.2	-0.8
Medication: Blood pressure	1.0	1.9	5.5	2.4	-0.2	-0.2
Ever smoked	1.0	1.7	2.6	-0.9	1.6	-1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	-1.6	-1.0	0.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.5	-1.6	0.4	1.6
Medication: Co-codamol	0.9	1.1	2.5	-1.6	0.8	-0.3
Past tobacco smoking	0.9	1.6	2.8	0.3	-1.7	1.4
Prospective memory result	0.9	1.2	3.0	-0.6	-1.7	-0.3
Exposure to tobacco smoke at home	0.9	1.0	2.7	-1.7	0.6	0.0
Worry too long after embarrassment	0.9	1.5	3.9	0.3	-0.7	2.0
Age at last live birth	0.9	1.3	3.1	-0.2	0.8	1.8
Arm fat percentage (left)	0.9	3.8	8.0	0.8	1.6	-2.8
Friendships satisfaction	0.9	1.2	1.4	1.0	1.2	-1.0
Commuting to job workplace: Walk	0.9	1.0	2.2	0.1	1.5	-0.8
Medication: Gliclazide	0.9	1.0	2.5	-0.5	-1.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	5.7	-0.1	2.4	0.1
Arm fat mass (left)	0.9	3.8	7.7	1.0	1.7	-2.8
Average weekly champagne plus white wine intake	0.9	1.3	2.4	1.1	1.6	-0.4
Commuting to job workplace: Cycle	0.9	1.1	2.0	1.0	0.4	-1.4
Heel T-Score	0.8	6.5	9.9	3.1	-2.8	1.3
Smoking Status	0.8	1.9	4.9	-0.4	2.2	-0.8
Taking other prescription medications	0.8	1.2	1.9	-1.4	-0.9	-1.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.5	0.1	-1.2	1.1
Body fat percentage	0.8	3.1	6.1	1.3	1.2	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	0.5	0.8	1.4
Back pain experienced in last month	0.8	1.1	3.1	-0.3	0.4	-1.8
Number of self-reported non-cancer illnesses	0.8	1.4	2.8	-1.7	-0.9	-0.8
Illnesses of father: High blood pressure	0.8	0.9	1.5	0.6	-1.2	0.9
Diastolic blood pressure, automated reading	0.8	2.4	5.4	2.3	0.3	-1.3
Heart disease (siblings)	0.8	1.0	1.9	1.0	1.4	0.3
Reaction Time	0.7	1.3	2.3	-1.2	1.5	0.4
Coronary Artery Disease (CAD)	0.7	0.8	2.3	-0.3	-1.5	0.0
BMI	0.7	4.0	6.2	-0.8	2.5	-2.2
Trunk fat percentage	0.7	2.8	5.3	1.5	1.0	-2.3
Body mass index (BMI)	0.7	3.1	5.0	0.3	2.0	-2.2
Trunk fat mass	0.7	2.8	4.9	1.5	1.2	-2.2
Medication: Simvastatin	0.7	1.0	2.6	-0.4	1.6	-0.4
Fluid intelligence score	0.7	1.5	2.2	0.8	1.5	1.3
Illnesses of siblings	0.7	0.9	2.2	-0.7	-1.5	0.3
Arm fat percentage (right)	0.7	2.9	6.0	0.5	1.6	-2.5
Time employed in main current job	0.7	0.8	1.6	0.2	1.3	-0.8
Father’s age at death	0.7	0.9	1.7	-1.3	-1.0	0.0
Hair/balding pattern: Pattern 3	0.7	1.0	1.8	-1.3	0.9	-0.6
Lung cancer (father)	0.7	0.9	1.1	-0.8	0.9	-1.0
Arm fat mass (right)	0.7	2.8	5.5	0.8	1.5	-2.4
Medication: Amlodipine	0.7	0.9	2.4	-0.5	0.3	1.6
Exposure to tobacco smoke outside home	0.7	0.9	2.1	-0.3	1.4	-0.7
Shortness of breath walking on level ground	0.7	0.8	1.6	0.2	-1.3	-0.9
Whole body fat mass	0.7	3.1	5.2	1.4	1.5	-2.3
Leg fat mass (right)	0.7	2.8	4.0	1.1	1.8	-2.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	0.9	-0.3	1.2
Loneliness, isolation	0.7	0.9	2.1	-1.4	0.9	0.1
Osteoporosis (self-reported)	0.7	0.8	1.8	-0.0	0.8	-1.3
Medication: Aspirin	0.7	0.9	2.4	-0.0	1.6	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	1.3	-1.1	0.5	-0.9
Financial situation satisfaction	0.7	0.8	2.1	-0.4	1.4	-0.4
Medication: Paracetamol	0.7	1.1	2.4	-0.9	1.6	0.2
Age started oral contraceptive pill	0.7	0.9	1.4	1.2	-0.5	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	-0.0	1.5	-0.7
Pack years of smoking	0.7	1.0	2.3	-0.9	1.5	-0.1
Leg fat mass (left)	0.7	2.9	4.9	0.8	1.8	-2.2
Neuroticism (2016)	0.6	0.9	1.7	-1.3	-0.9	0.0
Primary Biliary Cirrhosis	0.6	0.8	2.5	-1.6	-0.2	0.0
Blood Platelet Count	0.6	7.1	11.2	-2.8	3.3	1.5
Height	0.6	11.6	24.2	4.9	-3.2	0.7
Number of treatments/medications taken	0.6	1.0	2.9	-1.7	-0.2	-0.1
Supplements: Zinc	0.6	0.6	1.4	-0.3	0.5	1.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	-0.6	-1.3	0.2
Stomach or abdominal pain in last month	0.6	0.7	1.1	-0.9	-0.5	1.0
Financial difficulties in last 2 years	0.6	0.8	1.2	-0.8	1.1	0.7
Weight	0.6	3.1	5.2	1.7	1.1	-2.3
Impedance of arm (right)	0.6	2.7	4.4	1.1	-2.1	1.5
Depression (self-reported)	0.6	0.7	1.4	-0.7	-1.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.5	1.2	-1.1	-0.6
Leg fat percentage (right)	0.6	2.0	3.1	0.9	1.4	-1.8
Qualifications: College or University degree	0.6	1.9	3.1	1.7	-0.4	1.6
Medication: Ibuprofen	0.6	0.7	1.5	0.1	1.2	-0.7
Family relationship satisfaction	0.6	0.8	1.4	1.2	0.7	-0.7
Medication: Aspirin	0.6	0.8	1.9	-0.4	1.4	0.5
Qualifications: nursing, teaching	0.6	0.9	1.2	0.4	-1.1	-1.1
Smoking status: Current	0.6	0.9	2.3	-0.4	0.6	-1.5
Guilty feelings	0.6	0.9	1.3	0.4	-1.1	1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.0	1.0	-0.0	1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.8	-1.3	0.5	-0.3
Leg fat percentage (left)	0.6	2.2	4.6	0.5	1.4	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.3	-1.5	-0.2	0.0
Impedance of whole body	0.6	2.9	5.9	1.0	-2.4	1.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.2	0.7	1.1	1.8
Neuroticism (Nagel 2018)	0.5	1.1	2.4	-0.0	-0.9	1.6
Waist Hip Ratio (WHR)	0.5	2.3	5.2	-0.6	2.3	-1.2
Average weekly spirits intake	0.5	0.6	1.1	-1.1	-0.7	-0.4
Systolic blood pressure, automated reading	0.5	1.4	2.8	1.1	-1.7	0.4
Pack years adult smoking proportion	0.5	0.8	1.7	-0.7	1.3	-0.3
Leg fat-free mass (left)	0.5	2.7	4.3	1.4	1.4	-2.1
Current tobacco smoking	0.5	0.9	1.3	-0.7	1.1	-0.9
Age when periods started (menarche)	0.5	1.2	3.2	-0.1	1.8	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.2	1.8	0.6	0.2
Medication: Atenolol	0.5	0.6	1.6	0.4	1.2	-0.4
Sitting height	0.5	3.3	5.8	2.4	-1.6	1.2
Leg predicted mass (left)	0.5	2.6	3.9	1.4	1.4	-2.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	0.5	-1.3	-0.2
Diabetes (self-reported)	0.5	0.8	1.2	-1.1	-0.4	1.1
Impedance of arm (left)	0.5	2.3	4.2	1.4	-2.0	0.9
Tense / ‘highly strung’	0.5	0.9	1.9	0.8	-0.3	1.4
Loud music exposure frequency	0.5	0.6	0.8	-0.9	0.4	-0.8
Blood clot in the leg (DVT)	0.5	0.6	1.7	-0.1	1.3	-0.4
Arm fat-free mass (right)	0.5	2.6	4.9	1.3	1.1	-2.2
Number of full brothers	0.5	0.6	0.9	0.4	-0.9	0.9
Medication: Allopurinol	0.5	0.7	1.3	-0.8	1.2	-0.3
Arm predicted mass (right)	0.5	2.4	4.1	1.2	1.3	-2.0
Had major operations	0.5	0.6	1.5	0.6	-0.0	-1.2
Leg fat-free mass (right)	0.5	2.7	5.1	1.1	1.4	-2.2
Eye problems/disorders: Cataract	0.5	0.5	1.6	-0.1	1.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	1.3	0.1	-0.3
Leg predicted mass (right)	0.5	2.7	4.9	1.1	1.4	-2.2
Ever taken oral contraceptive pill	0.5	0.5	1.5	-1.2	0.4	0.1
Mother’s age at death	0.5	0.6	1.3	0.7	-0.2	1.2
Basal metabolic rate	0.5	2.7	4.1	1.5	1.3	-2.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	0.4	-1.3	-0.1
Alzheimer’s Disease (in father)	0.4	0.4	0.6	0.8	0.7	-0.2
Major Depression (MDD)	0.4	0.5	1.6	0.2	1.2	0.0
Ovarian Cancer	0.4	0.5	1.4	-0.2	0.0	-1.2
Bipolar Disorder (2011)	0.4	0.4	0.8	0.7	0.9	0.0
Systolic Blood Pressure	0.4	2.2	4.3	1.4	-2.1	0.5
Hypothyroidism (self reported)	0.4	0.8	2.4	0.1	-0.2	1.6
Lung FEV1/FVC ratio	0.4	1.9	2.8	-1.1	-1.3	1.7
Lung FVC	0.4	1.9	3.7	1.3	1.9	0.3
Impedance of leg (right)	0.4	2.0	2.5	1.4	-1.6	1.3
Number of incorrect matches in round	0.4	0.7	1.7	-0.1	1.3	-0.5
Had other major operations	0.4	0.5	1.1	-0.1	0.5	-1.1
Forced vital capacity (FVC)	0.4	1.6	2.5	1.6	1.4	-0.3
Neuroticism score	0.4	0.8	2.0	-0.5	-0.4	1.4
Hip circumference	0.4	1.7	2.1	1.1	1.5	-1.3
Number of live births	0.4	0.5	0.7	-0.8	0.8	0.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	0.1	0.4	-1.1
Standing height	0.4	4.1	9.4	3.1	-1.6	-0.3
Breastfed as a baby	0.4	0.5	0.8	-0.6	0.6	-0.9
Peak expiratory flow (PEF)	0.4	1.0	1.8	-0.6	-1.3	0.8
Glaucoma (self-reported)	0.4	0.5	0.9	0.4	-0.7	0.9
Forced vital capacity (FVC), Best measure	0.4	1.3	2.1	1.4	1.3	-0.5
Illnesses of father: Heart disease	0.4	0.5	0.9	0.6	-0.5	0.9
Whole body fat-free mass	0.4	2.4	3.7	1.4	1.3	-1.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	-1.0	0.6	0.5
Diabetes diagnosed by doctor	0.4	0.7	1.3	-0.9	0.1	1.1
Whole body water mass	0.4	2.3	3.2	1.4	1.2	-1.8
Arm fat-free mass (left)	0.4	1.9	3.7	0.9	1.1	-1.9
Risk taking	0.4	0.6	1.3	-0.4	1.1	0.7
Pain experienced in last month	0.4	0.7	1.2	-0.1	-1.1	1.0
Arm predicted mass (left)	0.4	2.3	4.4	1.1	1.2	-2.1
Bipolar Disorder (2018)	0.3	0.5	1.4	-0.2	1.2	0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	1.1	0.2	0.9
Mean Putamen Volume	0.3	0.3	0.6	0.7	-0.8	0.0
HDL Cholesterol	0.3	0.6	1.3	-1.1	-0.6	0.0
Blood White Count	0.3	1.9	4.2	-2.0	-0.8	0.9
Sensitivity / hurt feelings	0.3	0.5	1.5	-0.1	-1.2	-0.4
Diabetes (father)	0.3	0.4	1.0	0.3	-1.0	-0.4
Average weekly fortified wine intake	0.3	0.4	0.7	0.7	-0.8	0.3
Fed-up feelings	0.3	0.6	1.1	-0.5	0.7	-1.0
Relative age voice broke	0.3	0.4	0.9	0.9	-0.6	0.1
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.5	0.1	-0.9
Impedance of leg (left)	0.3	1.5	2.7	0.9	-1.6	0.9
Alcohol usually taken with meals	0.3	0.5	1.4	-0.2	-0.1	1.2
Had menopause	0.3	0.4	0.7	0.8	-0.3	0.6
Qualifications: None of the above	0.3	0.7	1.4	-1.2	0.8	-0.4
Heart attack	0.3	0.3	0.7	-0.5	0.8	-0.1
Trunk fat-free mass	0.3	1.9	2.3	1.5	1.1	-1.5
Worrier / anxious feelings	0.3	0.6	1.2	1.1	0.3	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.4	-1.2	0.4	-0.4
Trunk predicted mass	0.3	1.7	2.2	1.4	1.0	-1.5
Birth weight of first child	0.3	0.5	0.8	0.3	0.7	-0.9
Pulse wave reflection index	0.3	0.4	0.7	-0.3	0.6	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.2	-0.2	-1.1
High blood pressure (siblings)	0.3	0.5	0.7	0.8	0.6	0.6
Pulse wave peak to peak time	0.3	0.3	0.8	-0.0	-0.4	0.9
Medication: Blood pressure	0.3	0.6	1.1	-0.8	1.0	-0.0
Comparative height size at age 10	0.3	1.7	4.0	0.6	1.0	-2.0
Smoking status: Previous	0.3	0.5	1.2	-0.1	1.1	-0.5
Mood swings	0.3	0.5	0.7	-0.7	-0.6	-0.8
Breast cancer (self-reported)	0.3	0.3	0.6	-0.8	0.0	-0.6
Miserableness	0.3	0.6	0.7	-0.8	-0.5	0.9
Commuting to job workplace: Public transport	0.3	0.3	0.4	-0.7	-0.6	0.4
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	-0.6	0.5	0.7
Ever depressed for a whole week	0.3	0.4	0.9	1.0	-0.4	-0.3
Supplements: Calcium	0.3	0.4	0.6	0.4	-0.8	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.6	0.9	-0.3
Depressed Affect (Nagel 2018)	0.2	0.4	1.3	-1.1	0.1	0.0
Worry (Nagel 2018)	0.2	0.5	1.2	0.4	-1.1	0.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.6	-0.1	0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.9	0.1	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.6	0.7	0.0
Schizophrenia (2014)	0.2	0.4	1.0	1.0	0.2	0.0
Triglycerides	0.2	0.3	0.6	0.8	0.4	0.0
Neuroticism	0.2	0.4	1.3	0.0	-0.2	1.1
Relative age of first facial hair	0.2	0.4	1.1	-0.1	-1.1	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.7	0.7	0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.1	-0.1	-0.7
Diabetes (mother)	0.2	0.2	0.6	-0.8	0.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.3	0.6	-0.6	-0.4
High blood pressure	0.2	0.5	1.3	1.1	0.2	0.5
Medication: Levothyroxine sodium	0.2	0.4	1.2	-0.0	-0.0	1.1
Hearing difficulty/problems with background noise	0.2	0.4	0.5	-0.7	0.7	0.3
Pain all over the body in last month	0.2	0.3	0.7	0.2	0.8	-0.2
Falls in the last year	0.2	0.2	0.6	-0.3	0.0	-0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.9	1.0	0.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.0	0.9	-0.2
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.2	0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.2	0.3	-0.9
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	0.6	0.9	0.4
Medication: Paracetamol	0.2	0.4	0.5	-0.7	0.4	-0.7
Headache pain in last month	0.2	0.3	0.6	-0.7	0.2	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	-0.3	-0.2	0.9
Comparative body size at age 10	0.2	0.5	1.4	-0.2	0.3	-1.2
Age at first live birth	0.2	0.4	0.7	0.7	0.8	0.2
Health satisfaction	0.2	0.3	0.7	0.1	-0.3	-0.9
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.5	-0.1	-0.6
Angina (self-reported)	0.2	0.2	0.5	-0.7	-0.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.6	0.2	-0.5
Average weekly red wine intake	0.2	0.2	0.6	-0.4	-0.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.1	0.8	-0.6
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.8	-0.6	-0.3
Medication: Bendroflumethiazide	0.2	0.2	0.4	-0.5	0.6	-0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.5	-0.5	-0.5
Cholesterol lowering medication	0.2	0.3	0.5	0.3	-0.5	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.3	1.0	0.0
HbA1C	0.1	0.1	0.2	-0.4	-0.4	0.0
Cardiovascular Disease	0.1	0.5	1.0	-0.2	1.0	0.6
Hair Pigment	0.1	1.6	3.1	-1.8	-0.8	0.9
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.5	-0.2	-0.2
Angina	0.1	0.1	0.2	-0.4	-0.3	0.1
Medication: Metformin	0.1	0.2	0.4	-0.0	0.7	0.1
Maternal smoking around birth	0.1	0.2	0.3	-0.4	-0.2	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.7	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.6	0.8	0.8	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	0.5	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.3	-0.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.5	0.4	0.2
Hypertension (Self-reported)	0.1	0.4	0.8	0.9	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.2	0.7	-0.4
Medication for cholesterol	0.1	0.1	0.2	0.0	-0.2	0.5
Medication: Lisinopril	0.1	0.1	0.2	-0.1	0.5	0.3
Irritability	0.1	0.1	0.2	0.3	-0.3	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.9	-0.4	-0.2
Schizophrenia (2018)	0.0	0.1	0.1	0.3	0.3	0.0
Fasting Glucose	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.0	-0.2	-0.1	0.0
Tanning	0.0	0.2	0.5	-0.4	0.7	0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.3	0.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.1	0.0	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.1	-0.2	0.2
Average weekly beer plus cider intake	0.0	0.0	0.0	0.2	-0.1	-0.1

Hub : Genes

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Trait associations