Hub : Genes

SMURF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.114	0.043	0.00051	0.019	0.032	0.019	0.032	0.015	2.1e-03	7.5e-05	0.0022	8.5e-05	5.1e-03
2	GTEx	Esophagus Mucosa	0.127	0.050	0.00400	0.102	NA	0.039	NA	0.095	2.7e-07	NA	0.0012	NA	7.0e-07
3	TCGA	Thyroid Carcinoma	0.048	0.026	0.00630	0.005	0.000	0.007	NA	0.005	9.7e-02	3.6e-01	0.0680	NA	8.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	1.4	-0.2	1.2	0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.3	1.0	0.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.3	-1.1	0.1	0.0
Depression (Nagel 2018)	1.0	1.6	4.2	-0.7	2.1	0.0
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.2	0.7	1.1	1.8
Neuroticism (Nagel 2018)	0.5	1.1	2.4	-0.0	-0.9	1.6
Schizophrenia (2018)	0.0	0.1	0.1	0.3	0.3	0.0
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	-1.6	-1.0	0.0
Worry (Nagel 2018)	0.2	0.5	1.2	0.4	-1.1	0.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.6	-0.1	0.5
Alzheimer’s Disease (in father)	0.4	0.4	0.6	0.8	0.7	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.9	0.1	0.0
Crohns Disease (2017)	3.2	7.1	16.4	-4.0	2.1	-0.6
Irritable Bowel Disease (IBD)	4.6	10.9	25.5	-5.0	2.6	-0.5
Ulcerative Colitis (UC)	3.2	6.0	14.9	-3.9	1.8	-0.2
Major Depression (MDD)	0.4	0.5	1.6	0.2	1.2	0.0
Reaction Time	0.7	1.3	2.3	-1.2	1.5	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	1.1	0.2	0.9
Breast Cancer	1.2	2.9	8.4	2.9	0.6	0.1
Ovarian Cancer	0.4	0.5	1.4	-0.2	0.0	-1.2
Prostate Cancer	1.7	2.4	5.1	-0.0	1.4	-2.3
Age at First Birth	1.0	1.4	2.3	1.4	-1.5	0.0
Bipolar Disorder (2011)	0.4	0.4	0.8	0.7	0.9	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.6	0.7	0.0
Coronary Artery Disease (CAD)	0.7	0.8	2.3	-0.3	-1.5	0.0
Crohns Disease (2012)	1.1	1.8	5.1	-2.3	0.4	0.0
Mean Putamen Volume	0.3	0.3	0.6	0.7	-0.8	0.0
Fasting Glucose	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.1	0.1	0.2	-0.4	-0.4	0.0
HDL Cholesterol	0.3	0.6	1.3	-1.1	-0.6	0.0
LDL Cholesterol	1.5	2.4	7.2	0.1	-2.7	0.0
Lupus	0.0	0.0	0.0	-0.2	-0.1	0.0
Neuroticism (2016)	0.6	0.9	1.7	-1.3	-0.9	0.0
Primary Biliary Cirrhosis	0.6	0.8	2.5	-1.6	-0.2	0.0
Rheumatoid Arthritis	1.0	1.3	2.5	0.9	-0.8	-1.6
Schizophrenia (2014)	0.2	0.4	1.0	1.0	0.2	0.0
Triglycerides	0.2	0.3	0.6	0.8	0.4	0.0
Type 2 Diabetes (T2D) (2012)	2.2	2.6	7.3	-0.6	-2.7	0.0
Ulcerative Colitis	2.3	3.4	8.2	-2.9	1.4	0.0
Blood Eosinophil Count	1.0	7.4	21.0	-4.6	-0.5	-1.0
Blood Platelet Count	0.6	7.1	11.2	-2.8	3.3	1.5
Blood Red Count	2.9	27.6	50.4	-1.4	-5.5	7.1
Blood White Count	0.3	1.9	4.2	-2.0	-0.8	0.9
Heel T-Score	0.8	6.5	9.9	3.1	-2.8	1.3
BMI	0.7	4.0	6.2	-0.8	2.5	-2.2
Height	0.6	11.6	24.2	4.9	-3.2	0.7
Waist Hip Ratio (WHR)	0.5	2.3	5.2	-0.6	2.3	-1.2
Systolic Blood Pressure	0.4	2.2	4.3	1.4	-2.1	0.5
Smoking Status	0.8	1.9	4.9	-0.4	2.2	-0.8
Allergy or Eczema	1.3	3.3	5.5	-0.9	-2.3	-1.9
Cardiovascular Disease	0.1	0.5	1.0	-0.2	1.0	0.6
Hypothyroidism (self reported)	0.4	0.8	2.4	0.1	-0.2	1.6
Respiratory disease	2.3	5.1	7.6	-2.8	0.3	-2.8
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.5	-1.6	0.4	1.6
Lung FEV1/FVC ratio	0.4	1.9	2.8	-1.1	-1.3	1.7
Lung FVC	0.4	1.9	3.7	1.3	1.9	0.3
Neuroticism	0.2	0.4	1.3	0.0	-0.2	1.1
Chronotype (morning person)	1.1	2.6	7.4	2.7	-0.6	0.3
Hair Pigment	0.1	1.6	3.1	-1.8	-0.8	0.9
Tanning	0.0	0.2	0.5	-0.4	0.7	0.0
Hand grip strength (left)	1.7	4.5	10.5	3.2	-1.2	1.2
Number of treatments/medications taken	0.6	1.0	2.9	-1.7	-0.2	-0.1
Average weekly spirits intake	0.5	0.6	1.1	-1.1	-0.7	-0.4
Sensitivity / hurt feelings	0.3	0.5	1.5	-0.1	-1.2	-0.4
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.3	0.2	0.1
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.5	-0.2	-0.2
Relative age of first facial hair	0.2	0.4	1.1	-0.1	-1.1	0.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.3	-0.6	1.0	-2.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.7	0.7	0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.1	-0.1	-0.7
Systolic blood pressure, automated reading	0.5	1.4	2.8	1.1	-1.7	0.4
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.9	-0.5	-2.0	0.3
Angina	0.1	0.1	0.2	-0.4	-0.3	0.1
Medication for hormone replacement therapy	1.0	1.2	3.1	-1.8	0.6	-0.0
Vitamin and mineral supplements	1.7	2.4	4.8	0.8	2.2	-1.2
Supplements: Zinc	0.6	0.6	1.4	-0.3	0.5	1.2
Medication: Co-codamol	0.9	1.1	2.5	-1.6	0.8	-0.3
Medication: Metformin	0.1	0.2	0.4	-0.0	0.7	0.1
Diabetes (father)	0.3	0.4	1.0	0.3	-1.0	-0.4
Diabetes (mother)	0.2	0.2	0.6	-0.8	0.1	0.2
Severe depression (siblings)	1.5	1.7	3.4	0.8	-1.1	1.8
Pack years adult smoking proportion	0.5	0.8	1.7	-0.7	1.3	-0.3
Impedance of leg (right)	0.4	2.0	2.5	1.4	-1.6	1.3
Leg fat-free mass (left)	0.5	2.7	4.3	1.4	1.4	-2.1
Trunk fat percentage	0.7	2.8	5.3	1.5	1.0	-2.3
Hand grip strength (right)	1.5	4.2	9.7	3.1	-1.6	0.5
Townsend deprivation index at recruitment	2.1	2.9	7.2	-2.7	1.2	-0.0
Current tobacco smoking	0.5	0.9	1.3	-0.7	1.1	-0.9
Average weekly fortified wine intake	0.3	0.4	0.7	0.7	-0.8	0.3
Maternal smoking around birth	0.1	0.2	0.3	-0.4	-0.2	0.6
Fed-up feelings	0.3	0.6	1.1	-0.5	0.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.0	-0.3	2.0	-0.9
Relative age voice broke	0.3	0.4	0.9	0.9	-0.6	0.1
Taking other prescription medications	0.8	1.2	1.9	-1.4	-0.9	-1.0
Age when periods started (menarche)	0.5	1.2	3.2	-0.1	1.8	0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	-0.6	-1.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.2	1.8	0.6	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.3	0.6	-0.6	-0.4
Qualifications: CSEs or equivalent	1.4	1.8	4.4	-2.1	0.8	0.7
Serious illness, injury or assault to yourself	0.3	0.3	0.8	-0.5	0.1	-0.9
High blood pressure	0.2	0.5	1.3	1.1	0.2	0.5
Hayfever, allergic rhinitis or eczema	2.2	4.7	7.6	0.0	-2.8	-2.5
Multivitamins +/- minerals	2.7	3.5	7.0	1.4	-2.6	1.2
Stomach or abdominal pain in last month	0.6	0.7	1.1	-0.9	-0.5	1.0
Supplements: Glucosamine	1.7	2.2	5.8	2.4	-0.2	-0.8
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	2.9	1.7	-1.6	-1.0
Medication: Atenolol	0.5	0.6	1.6	0.4	1.2	-0.4
Medication: Levothyroxine sodium	0.2	0.4	1.2	-0.0	-0.0	1.1
Sitting height	0.5	3.3	5.8	2.4	-1.6	1.2
Chronic bronchitis/emphysema (father)	1.4	1.6	2.8	-1.4	-0.3	-1.7
High blood pressure (mother)	1.3	1.8	3.5	1.4	-0.2	-1.9
Body mass index (BMI)	0.7	3.1	5.0	0.3	2.0	-2.2
Impedance of leg (left)	0.3	1.5	2.7	0.9	-1.6	0.9
Leg predicted mass (left)	0.5	2.6	3.9	1.4	1.4	-2.0
Trunk fat mass	0.7	2.8	4.9	1.5	1.2	-2.2
Waist circumference	1.3	4.9	7.6	0.6	2.8	-2.6
Number of incorrect matches in round	0.4	0.7	1.7	-0.1	1.3	-0.5
Past tobacco smoking	0.9	1.6	2.8	0.3	-1.7	1.4
Alcohol usually taken with meals	0.3	0.5	1.4	-0.2	-0.1	1.2
Nervous feelings	1.4	2.6	6.9	-0.3	-0.9	2.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.7	-0.0	-0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.5	-0.7	0.7	0.3
Hair/balding pattern: Pattern 2	1.0	1.3	3.2	0.9	-1.8	-0.0
Had menopause	0.3	0.4	0.7	0.8	-0.3	0.6
Had other major operations	0.4	0.5	1.1	-0.1	0.5	-1.1
Forced vital capacity (FVC)	0.4	1.6	2.5	1.6	1.4	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.0	2.2	0.9	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	0.5	-1.3	-0.2
Qualifications: None of the above	0.3	0.7	1.4	-1.2	0.8	-0.4
Financial difficulties in last 2 years	0.6	0.8	1.2	-0.8	1.1	0.7
Mouth/teeth dental problems	1.2	1.8	4.4	2.1	-0.9	-0.5
Heart attack	0.3	0.3	0.7	-0.5	0.8	-0.1
Allergy	1.6	3.6	7.5	1.4	1.1	2.7
Pain all over the body in last month	0.2	0.3	0.7	0.2	0.8	-0.2
Diabetes (self-reported)	0.5	0.8	1.2	-1.1	-0.4	1.1
Hayfever/allergic rhinitis (self-reported)	4.6	6.0	14.4	1.3	-3.8	-1.4
Medication: Ramipril	1.0	1.2	2.9	0.2	1.7	-0.9
Medication: Simvastatin	0.7	1.0	2.6	-0.4	1.6	-0.4
Fluid intelligence score	0.7	1.5	2.2	0.8	1.5	1.3
Illnesses of siblings	0.7	0.9	2.2	-0.7	-1.5	0.3
Neuroticism score	0.4	0.8	2.0	-0.5	-0.4	1.4
Weight	0.6	3.1	5.2	1.7	1.1	-2.3
Impedance of arm (right)	0.6	2.7	4.4	1.1	-2.1	1.5
Arm fat percentage (right)	0.7	2.9	6.0	0.5	1.6	-2.5
Trunk fat-free mass	0.3	1.9	2.3	1.5	1.1	-1.5
Hip circumference	0.4	1.7	2.1	1.1	1.5	-1.3
Time employed in main current job	0.7	0.8	1.6	0.2	1.3	-0.8
Alcohol intake versus 10 years previously	1.2	1.8	2.5	-1.6	1.4	-0.9
Father’s age at death	0.7	0.9	1.7	-1.3	-1.0	0.0
Worrier / anxious feelings	0.3	0.6	1.2	1.1	0.3	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.4	-1.2	0.4	-0.4
Falls in the last year	0.2	0.2	0.6	-0.3	0.0	-0.8
Hair/balding pattern: Pattern 3	0.7	1.0	1.8	-1.3	0.9	-0.6
Number of live births	0.4	0.5	0.7	-0.8	0.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.9	1.0	0.8	0.5
Pulse rate	1.8	3.1	5.7	0.8	1.7	-2.4
Happiness	1.3	1.5	4.5	0.1	0.2	-2.1
Noisy workplace	2.1	2.6	4.7	-1.1	2.2	-1.4
Qualifications: A levels/AS levels or equivalent	1.1	2.4	6.5	2.5	-0.8	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.1	0.0	-0.3
Mouth/teeth dental problems: Dentures	1.7	2.8	7.5	-2.7	-0.2	0.9
Asthma	1.3	2.6	5.7	-2.4	1.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.0	0.9	-0.2
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.2	0.7	-0.5
Depression (self-reported)	0.6	0.7	1.4	-0.7	-1.2	0.6
Medication: Lansoprazole	2.0	2.2	6.5	-0.2	-0.4	-2.6
Prospective memory result	0.9	1.2	3.0	-0.6	-1.7	-0.3
Lung cancer (father)	0.7	0.9	1.1	-0.8	0.9	-1.0
Illnesses of mother	1.0	1.2	2.0	1.2	-1.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.6	0.8	0.8	0.3
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	0.1	0.4	-1.1
Impedance of arm (left)	0.5	2.3	4.2	1.4	-2.0	0.9
Arm fat mass (right)	0.7	2.8	5.5	0.8	1.5	-2.4
Trunk predicted mass	0.3	1.7	2.2	1.4	1.0	-1.5
Standing height	0.4	4.1	9.4	3.1	-1.6	-0.3
Length of working week for main job	1.3	1.5	3.3	1.0	0.1	-1.8
Exposure to tobacco smoke at home	0.9	1.0	2.7	-1.7	0.6	0.0
Breastfed as a baby	0.4	0.5	0.8	-0.6	0.6	-0.9
Tense / ‘highly strung’	0.5	0.9	1.9	0.8	-0.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.2	0.3	-0.9
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	0.6	0.9	0.4
Birth weight of first child	0.3	0.5	0.8	0.3	0.7	-0.9
Peak expiratory flow (PEF)	0.4	1.0	1.8	-0.6	-1.3	0.8
Pulse wave reflection index	0.3	0.4	0.7	-0.3	0.6	0.8
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.6	0.2	0.9	-1.6
Loud music exposure frequency	0.5	0.6	0.8	-0.9	0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.4	1.1	-1.8	-0.2
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.4	-0.1	2.3	-1.2
Blood clot in the leg (DVT)	0.5	0.6	1.7	-0.1	1.3	-0.4
Medication: Paracetamol	0.2	0.4	0.5	-0.7	0.4	-0.7
Headache pain in last month	0.2	0.3	0.6	-0.7	0.2	-0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.5	1.2	-1.1	-0.6
Glaucoma (self-reported)	0.4	0.5	0.9	0.4	-0.7	0.9
Gout (self-reported)	1.4	1.9	3.5	-0.3	1.9	-1.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	-0.3	-0.2	0.9
Medication: Amlodipine	0.7	0.9	2.4	-0.5	0.3	1.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.2	-0.2	-1.1
Birth weight	2.2	4.7	7.3	2.7	0.5	-2.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.5	0.1	-1.2	1.1
High blood pressure (siblings)	0.3	0.5	0.7	0.8	0.6	0.6
Forced vital capacity (FVC), Best measure	0.4	1.3	2.1	1.4	1.3	-0.5
Body fat percentage	0.8	3.1	6.1	1.3	1.2	-2.5
Leg fat percentage (right)	0.6	2.0	3.1	0.9	1.4	-1.8
Arm fat-free mass (right)	0.5	2.6	4.9	1.3	1.1	-2.2
Exposure to tobacco smoke outside home	0.7	0.9	2.1	-0.3	1.4	-0.7
Comparative body size at age 10	0.2	0.5	1.4	-0.2	0.3	-1.2
Number of full brothers	0.5	0.6	0.9	0.4	-0.9	0.9
Worry too long after embarrassment	0.9	1.5	3.9	0.3	-0.7	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.1	-0.2	0.2
Wheeze or whistling in the chest in last year	3.2	5.6	8.2	-2.7	1.2	-2.9
Number of children fathered	1.1	1.2	1.8	-1.3	0.8	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	0.5	0.8	1.4
Age at first live birth	0.2	0.4	0.7	0.7	0.8	0.2
Pulse wave peak to peak time	0.3	0.3	0.8	-0.0	-0.4	0.9
Health satisfaction	0.2	0.3	0.7	0.1	-0.3	-0.9
Shortness of breath walking on level ground	0.7	0.8	1.6	0.2	-1.3	-0.9
Qualifications: College or University degree	0.6	1.9	3.1	1.7	-0.4	1.6
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.5	-0.1	-0.6
Mouth/teeth dental problems: Loose teeth	2.2	2.6	6.0	-1.2	2.4	-0.6
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	0.5	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.3	-0.6	0.4
Neck or shoulder pain in last month	1.6	2.3	4.2	1.6	-0.2	-2.1
Medication: Blood pressure	0.3	0.6	1.1	-0.8	1.0	-0.0
Angina (self-reported)	0.2	0.2	0.5	-0.7	-0.4	0.3
Migraine (self-reported)	1.0	1.3	2.4	-0.9	-0.8	-1.5
Medication: Ibuprofen	0.6	0.7	1.5	0.1	1.2	-0.7
Medication: Allopurinol	0.5	0.7	1.3	-0.8	1.2	-0.3
Medication: Omeprazole	1.1	1.3	3.3	-1.8	0.6	0.4
Medication: Seretide 50 evohaler	2.2	2.5	3.6	1.9	1.3	-1.5
Mean time to correctly identify matches	1.2	2.2	3.6	-1.7	1.9	0.4
Heart disease (mother)	1.6	2.0	5.8	-0.1	2.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.6	0.2	-0.5
Whole body fat mass	0.7	3.1	5.2	1.4	1.5	-2.3
Leg fat mass (right)	0.7	2.8	4.0	1.1	1.8	-2.0
Arm predicted mass (right)	0.5	2.4	4.1	1.2	1.3	-2.0
Pulse rate, automated reading	3.0	9.6	21.6	1.2	4.7	-2.4
Alcohol intake frequency.	2.7	6.3	13.8	-3.7	-0.5	2.2
Comparative height size at age 10	0.3	1.7	4.0	0.6	1.0	-2.0
Number of full sisters	1.0	1.3	2.2	-1.2	1.5	-0.2
Suffer from ‘nerves’	1.2	1.9	5.3	-0.5	-0.6	2.3
Overall health rating	1.7	3.6	5.9	-2.1	2.4	-0.7
Chest pain or discomfort	1.4	2.0	3.0	-1.1	1.7	-1.4
Had major operations	0.5	0.6	1.5	0.6	-0.0	-1.2
Age at last live birth	0.9	1.3	3.1	-0.2	0.8	1.8
Family relationship satisfaction	0.6	0.8	1.4	1.2	0.7	-0.7
Leg pain on walking	1.2	1.5	4.3	-2.1	0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.5	0.4	0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	0.9	-0.3	1.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.4	0.9	-1.2	1.5
Medication: Aspirin	0.6	0.8	1.9	-0.4	1.4	0.5
Supplements: Vitamin C	1.2	1.4	3.1	-1.8	-0.2	1.0
Knee pain experienced in last month	1.6	2.4	5.4	-1.1	0.8	-2.3
Hypertension (Self-reported)	0.1	0.4	0.8	0.9	0.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.9	-1.7	-1.2	0.2
Illnesses of father: Heart disease	0.4	0.5	0.9	0.6	-0.5	0.9
Illnesses of siblings: Diabetes	1.2	1.5	2.5	-1.1	-0.9	-1.6
Smoking status: Previous	0.3	0.5	1.2	-0.1	1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.2	0.7	-0.4
Whole body fat-free mass	0.4	2.4	3.7	1.4	1.3	-1.9
Leg fat-free mass (right)	0.5	2.7	5.1	1.1	1.4	-2.2
Arm fat percentage (left)	0.9	3.8	8.0	0.8	1.6	-2.8
Average weekly red wine intake	0.2	0.2	0.6	-0.4	-0.1	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	-1.0	0.6	0.5
Mood swings	0.3	0.5	0.7	-0.7	-0.6	-0.8
Loneliness, isolation	0.7	0.9	2.1	-1.4	0.9	0.1
Long-standing illness, disability or infirmity	1.3	2.0	5.8	-2.4	-0.4	-0.4
Ever had bowel cancer screening	1.4	1.6	2.8	1.7	0.6	-1.3
Diabetes diagnosed by doctor	0.4	0.7	1.3	-0.9	0.1	1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	6.2	2.5	-0.1	-1.3
Friendships satisfaction	0.9	1.2	1.4	1.0	1.2	-1.0
Qualifications: nursing, teaching	0.6	0.9	1.2	0.4	-1.1	-1.1
Commuting to job workplace: Walk	0.9	1.0	2.2	0.1	1.5	-0.8
Eye problems/disorders: Cataract	0.5	0.5	1.6	-0.1	1.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.1	0.8	-0.6
Medication for cholesterol	0.1	0.1	0.2	0.0	-0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	1.3	0.1	-0.3
Back pain experienced in last month	0.8	1.1	3.1	-0.3	0.4	-1.8
Mineral and other dietary supplements	1.4	1.8	4.4	-0.4	2.1	-1.0
Breast cancer (self-reported)	0.3	0.3	0.6	-0.8	0.0	-0.6
Asthma (self-reported)	1.1	2.1	4.3	-2.1	0.9	-1.1
Osteoporosis (self-reported)	0.7	0.8	1.8	-0.0	0.8	-1.3
Osteoarthritis (self-reported)	1.0	1.3	1.9	-0.9	1.0	-1.4
Medication: Aspirin	0.7	0.9	2.4	-0.0	1.6	0.5
Medication: Gliclazide	0.9	1.0	2.5	-0.5	-1.6	0.6
Illnesses of father: None of the above (group 1)	0.7	0.8	1.3	-1.1	0.5	-0.9
Smoking status: Current	0.6	0.9	2.3	-0.4	0.6	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	5.7	-0.1	2.4	0.1
Whole body water mass	0.4	2.3	3.2	1.4	1.2	-1.8
Leg predicted mass (right)	0.5	2.7	4.9	1.1	1.4	-2.2
Arm fat mass (left)	0.9	3.8	7.7	1.0	1.7	-2.8
Number of self-reported non-cancer illnesses	0.8	1.4	2.8	-1.7	-0.9	-0.8
Average weekly champagne plus white wine intake	0.9	1.3	2.4	1.1	1.6	-0.4
Miserableness	0.3	0.6	0.7	-0.8	-0.5	0.9
Guilty feelings	0.6	0.9	1.3	0.4	-1.1	1.2
Wears glasses or contact lenses	1.0	1.2	1.4	1.2	-1.2	-0.8
Ever taken oral contraceptive pill	0.5	0.5	1.5	-1.2	0.4	0.1
Hearing aid user	1.3	1.4	3.0	0.4	-1.7	1.1
Mother’s age at death	0.5	0.6	1.3	0.7	-0.2	1.2
Financial situation satisfaction	0.7	0.8	2.1	-0.4	1.4	-0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.0	1.0	-0.0	1.0
Commuting to job workplace: Public transport	0.3	0.3	0.4	-0.7	-0.6	0.4
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	-0.6	0.5	0.7
Medication: Blood pressure	1.0	1.9	5.5	2.4	-0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.8	-1.3	0.5	-0.3
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.2	-0.9	-2.1	0.9
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.8	-0.6	-0.3
Medication: Bendroflumethiazide	0.2	0.2	0.4	-0.5	0.6	-0.3
Medication: Paracetamol	0.7	1.1	2.4	-0.9	1.6	0.2
Medication: Lisinopril	0.1	0.1	0.2	-0.1	0.5	0.3
Medication: Atorvastatin	1.1	1.3	2.0	0.9	-1.4	-1.1
Illnesses of father: High blood pressure	0.8	0.9	1.5	0.6	-1.2	0.9
Alcohol drinker status: Never	1.9	2.3	3.0	-1.2	-1.7	1.6
Ever smoked	1.0	1.7	2.6	-0.9	1.6	-1.3
Basal metabolic rate	0.5	2.7	4.1	1.5	1.3	-2.0
Leg fat percentage (left)	0.6	2.2	4.6	0.5	1.4	-2.1
Arm fat-free mass (left)	0.4	1.9	3.7	0.9	1.1	-1.9
Number of operations (self-reported)	1.1	1.6	3.6	1.1	0.1	-1.9
Average weekly beer plus cider intake	0.0	0.0	0.0	0.2	-0.1	-0.1
Irritability	0.1	0.1	0.2	0.3	-0.3	-0.5
Risk taking	0.4	0.6	1.3	-0.4	1.1	0.7
Ever had prostate specific antigen (PSA) test	1.7	2.0	5.2	0.8	-2.3	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.5	-0.5	-0.5
Age started oral contraceptive pill	0.7	0.9	1.4	1.2	-0.5	-1.0
Diastolic blood pressure, automated reading	0.8	2.4	5.4	2.3	0.3	-1.3
Ever depressed for a whole week	0.3	0.4	0.9	1.0	-0.4	-0.3
Unable to work because of sickness or disability	3.3	4.2	9.7	-3.1	1.4	-1.1
Commuting to job workplace: Cycle	0.9	1.1	2.0	1.0	0.4	-1.4
Myopia	3.0	4.3	8.0	2.0	-2.8	-0.9
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.9	-0.4	-0.2
Cholesterol lowering medication	0.2	0.3	0.5	0.3	-0.5	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.3	-1.5	-0.2	0.0
Pain experienced in last month	0.4	0.7	1.2	-0.1	-1.1	1.0
Supplements: Calcium	0.3	0.4	0.6	0.4	-0.8	0.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	0.4	-1.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.6	0.9	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	-0.0	1.5	-0.7
Heart disease (siblings)	0.8	1.0	1.9	1.0	1.4	0.3
Alcohol drinker status: Previous	2.1	2.4	6.5	-0.9	-0.0	2.6
Pack years of smoking	0.7	1.0	2.3	-0.9	1.5	-0.1
Impedance of whole body	0.6	2.9	5.9	1.0	-2.4	1.3
Leg fat mass (left)	0.7	2.9	4.9	0.8	1.8	-2.2
Arm predicted mass (left)	0.4	2.3	4.4	1.1	1.2	-2.1