Hub : Genes

SNCAIP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0530	0.0260	0.01200	0.024	0.017	0.028	0.021	0.024	0.00056	3.1e-03	2.2e-04	1.2e-03	5.2e-04
2	GTEx	Brain Cerebellum	0.2750	0.0780	0.00017	-0.009	NA	0.026	NA	0.019	0.78000	NA	5.6e-02	NA	8.7e-02
3	METSIM	Adipose	0.0433	0.0217	0.00590	0.000	0.008	0.006	0.008	0.004	0.35000	2.2e-02	3.7e-02	1.8e-02	7.7e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.0987	0.0321	0.00013	0.025	0.033	0.064	0.052	0.053	0.00030	3.4e-05	1.1e-08	2.8e-07	2.3e-07
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0399	0.0242	0.00400	0.000	0.008	-0.001	NA	0.003	0.28000	3.5e-02	4.0e-01	NA	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.9	4.5	1.0	1.6	-0.5	1.3	-2.1
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	0.1	-0.4	-0.9	0.9	0.2
Depressed Affect (Nagel 2018)	1.5	3.1	5.5	-0.3	1.8	-1.3	-2.4	-2.1
Depression (Nagel 2018)	0.3	0.4	0.8	0.7	0.4	0.8	-0.1	-0.9
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	-0.8	0.1	0.5	0.1	0.3
Neuroticism (Nagel 2018)	0.8	1.8	4.2	-0.7	0.4	-1.2	-2.0	-1.7
Schizophrenia (2018)	0.8	1.7	4.1	-0.7	-1.9	-0.7	0.1	2.0
Schizophrenia vs Biploar Disorder	2.1	2.7	4.7	-1.3	-1.9	-1.1	-1.6	2.2
Worry (Nagel 2018)	1.2	2.4	4.2	-1.8	-0.9	-2.0	-2.0	0.3
Alzheimer’s Disease (in mother)	0.3	0.3	1.0	-0.3	0.5	1.0	0.6	-0.1
Alzheimer’s Disease (in father)	0.2	0.3	0.7	-0.5	-0.8	0.4	-0.1	0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	-0.3	0.2	1.1	0.4	-0.3
Crohns Disease (2017)	0.3	0.6	1.9	-0.1	1.4	-0.8	-0.1	-0.6
Irritable Bowel Disease (IBD)	0.4	1.0	2.9	-0.8	0.3	-1.7	-1.2	-0.0
Ulcerative Colitis (UC)	1.0	1.9	3.1	-1.6	-0.8	-1.6	-1.8	0.6
Major Depression (MDD)	2.1	2.5	5.8	-0.8	-1.8	-1.4	1.0	2.4
Reaction Time	0.5	0.9	1.3	0.6	1.1	1.0	1.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	-0.2	-0.8	0.7	0.2	0.2
Breast Cancer	2.1	5.2	15.8	1.6	2.0	1.9	-0.2	-4.0
Ovarian Cancer	0.5	0.6	1.9	0.7	0.6	0.5	0.2	-1.4
Prostate Cancer	0.4	0.5	1.9	-0.3	-0.4	-0.5	-0.6	1.4
Age at First Birth	0.2	0.3	0.5	-0.7	-0.6	0.6	0.2	0.6
Bipolar Disorder (2011)	1.2	1.1	2.5	0.9	1.6	0.6	0.4	-1.4
Body Mass Index (BMI) (2010)	0.8	1.1	2.8	-1.0	-1.2	-1.7	-0.7	0.1
Coronary Artery Disease (CAD)	0.4	0.4	1.1	0.6	1.0	-0.6	-0.6	0.1
Crohns Disease (2012)	0.2	0.3	0.8	-0.9	-0.1	-0.6	-0.3	0.3
Mean Putamen Volume	0.3	0.3	0.7	-0.3	0.5	-0.9	-0.4	-0.4
Fasting Glucose	1.1	1.3	3.4	-0.8	0.8	-1.9	0.3	-1.3
HbA1C	2.7	3.0	6.0	-1.8	-1.2	-1.9	-2.4	0.8
HDL Cholesterol	0.6	1.0	3.0	1.2	-0.1	-0.7	1.7	-0.2
LDL Cholesterol	0.6	1.0	3.0	-0.0	0.7	0.5	-1.7	-1.1
Lupus	0.4	0.6	1.9	0.1	-1.4	-0.3	0.6	0.7
Neuroticism (2016)	1.7	2.4	3.4	-1.8	-1.6	-1.9	-1.3	1.1
Primary Biliary Cirrhosis	0.3	0.4	0.9	0.4	-0.0	-0.7	1.0	0.6
Rheumatoid Arthritis	0.4	0.6	1.4	0.4	-0.9	-1.2	0.5	0.4
Schizophrenia (2014)	1.0	2.2	5.7	-0.2	-2.0	-0.6	1.1	2.4
Triglycerides	1.2	1.9	5.8	-1.9	-0.0	0.2	-2.4	0.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.8	0.5	0.9	-1.1	0.6	-1.4
Ulcerative Colitis	3.2	4.7	7.0	-2.1	-2.6	-2.0	-1.7	2.3
Blood Eosinophil Count	0.1	0.8	2.0	1.2	-0.4	-0.5	1.4	-0.1
Blood Platelet Count	0.1	1.3	3.8	0.9	-0.6	-1.0	-0.6	-1.9
Blood Red Count	0.1	0.6	1.3	1.2	0.7	0.9	0.4	-0.6
Blood White Count	0.4	2.9	4.7	2.1	-0.8	-2.2	1.0	-1.8
Heel T-Score	1.2	9.8	26.4	1.6	5.1	1.5	-1.2	-4.1
BMI	0.2	1.0	2.8	0.7	0.2	-0.9	1.0	-1.7
Height	0.3	5.6	10.1	-0.2	2.7	-3.2	-2.6	-1.9
Waist Hip Ratio (WHR)	0.4	2.0	4.2	1.5	1.8	-2.0	0.3	-0.6
Systolic Blood Pressure	1.5	7.6	17.1	-2.9	0.2	-4.1	-3.5	0.0
Smoking Status	0.2	0.4	1.6	-0.2	-0.2	-1.3	0.7	-0.1
Allergy or Eczema	1.0	2.6	6.7	0.1	-1.6	-0.1	2.6	1.9
Cardiovascular Disease	0.2	0.6	2.0	-0.3	-0.4	-1.0	-1.4	0.2
Hypothyroidism (self reported)	0.3	0.7	1.4	-0.9	0.0	1.2	-0.7	-1.0
Respiratory disease	0.7	1.5	6.3	-0.5	-0.4	-0.7	-0.3	2.5
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.6	1.9	-0.8	1.3	0.2	-0.6
Lung FEV1/FVC ratio	3.8	19.1	32.0	4.5	4.1	4.3	2.7	-5.7
Lung FVC	1.2	6.1	11.7	-1.9	2.1	3.4	-2.9	-1.7
Neuroticism	1.2	3.0	7.0	-1.7	-0.8	-2.1	-2.6	0.2
Chronotype (morning person)	1.9	4.4	6.8	-2.3	-1.0	-2.5	-2.6	1.5
Hair Pigment	0.1	2.5	5.1	1.7	-1.6	2.2	1.4	-0.4
Tanning	0.3	3.4	4.9	-2.1	-1.1	-2.2	-2.2	1.2
Hand grip strength (left)	0.6	1.7	4.8	-2.2	-0.3	-1.1	-1.2	1.0
Number of treatments/medications taken	1.1	1.9	4.3	-0.9	-1.4	-2.1	-0.7	1.4
Average weekly spirits intake	0.7	0.9	2.1	0.4	-1.2	0.8	1.5	0.1
Sensitivity / hurt feelings	0.5	0.8	1.7	-1.3	-0.4	-0.6	-1.0	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.6	1.3	-0.2	0.2	-0.1	-0.9
Hearing difficulty/problems: Yes	0.8	1.2	3.3	1.8	1.1	0.2	1.0	-0.6
Relative age of first facial hair	0.4	0.9	2.0	-0.7	-1.0	-0.1	0.9	1.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.3	2.1	0.4	1.1	1.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.9	-0.0	-0.1	0.7	1.4	0.1
Ever had hysterectomy (womb removed)	0.9	1.1	2.7	-1.6	-0.0	-0.8	-1.4	0.1
Systolic blood pressure, automated reading	1.4	4.2	9.2	-2.2	0.7	-3.0	-2.5	-0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	1.0	0.2	-0.1	0.0	-0.3
Angina	0.3	0.4	1.1	1.1	0.3	0.7	0.5	-0.1
Medication for hormone replacement therapy	1.4	1.5	3.2	1.2	0.0	1.8	1.7	-0.4
Vitamin and mineral supplements	0.6	0.8	1.1	1.0	-1.0	-0.2	1.0	0.9
Supplements: Zinc	0.8	0.9	1.7	1.3	0.7	0.7	1.1	-0.8
Medication: Co-codamol	1.9	2.2	5.8	-1.2	-1.2	-2.4	-0.8	1.3
Medication: Metformin	0.3	0.4	0.6	0.6	-0.2	0.6	-0.8	-0.8
Diabetes (father)	0.3	0.4	0.8	-0.6	-0.9	0.3	0.4	0.8
Diabetes (mother)	1.3	1.6	3.3	1.2	0.9	-1.8	0.4	-1.5
Severe depression (siblings)	0.1	0.1	0.5	0.7	0.1	-0.0	0.0	0.2
Pack years adult smoking proportion	4.2	6.5	10.2	3.2	3.0	0.7	1.7	-3.1
Impedance of leg (right)	0.4	1.7	4.0	1.1	1.6	2.0	0.9	-0.2
Leg fat-free mass (left)	0.3	1.5	4.7	-0.7	-0.2	-2.2	-1.1	-1.1
Trunk fat percentage	0.1	0.4	1.1	0.5	0.2	-0.2	1.1	-0.6
Hand grip strength (right)	0.5	1.2	4.3	-2.1	-0.2	-0.4	-0.7	1.1
Townsend deprivation index at recruitment	0.8	1.1	3.0	0.5	1.2	-0.5	0.7	-1.7
Current tobacco smoking	0.4	0.7	1.4	1.1	-0.4	-0.4	1.2	-0.7
Average weekly fortified wine intake	0.5	0.6	1.6	0.7	1.3	-0.3	0.7	-0.7
Maternal smoking around birth	1.2	1.7	3.8	-1.8	-0.5	-2.0	-0.8	0.6
Fed-up feelings	1.4	2.5	6.7	-0.7	0.3	-2.1	-2.6	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	0.6	0.2	0.1	-0.5	-1.2
Relative age voice broke	0.3	0.5	1.0	0.9	-1.0	-0.0	0.8	-0.0
Taking other prescription medications	0.4	0.7	2.7	-0.2	-0.8	-1.6	-0.2	-0.1
Age when periods started (menarche)	0.8	2.0	8.4	0.6	-0.1	-2.9	1.2	-0.2
Bilateral oophorectomy (both ovaries removed)	2.1	2.5	5.7	0.2	2.4	0.7	-1.0	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	10.5	1.6	3.2	0.4	-0.2	-3.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	1.2	0.7	0.8	0.7	-0.1
Qualifications: CSEs or equivalent	3.4	4.4	10.3	1.6	1.9	2.3	-0.6	-3.2
Serious illness, injury or assault to yourself	2.7	3.2	6.5	0.6	2.1	1.6	-1.5	-2.5
High blood pressure	0.8	2.4	4.8	-0.9	-1.8	-1.7	-0.5	2.2
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.2	0.2	-1.6	0.2	2.1	1.9
Multivitamins +/- minerals	0.5	0.7	2.1	-0.7	0.6	0.1	-1.4	-0.8
Stomach or abdominal pain in last month	1.0	1.2	3.1	-1.0	-1.2	0.4	-0.2	1.8
Supplements: Glucosamine	1.1	1.4	5.9	0.1	0.8	2.4	-0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	-0.8	-0.8	-1.1	0.1	1.1
Medication: Atenolol	0.4	0.5	0.6	0.7	-0.7	-0.6	0.6	0.7
Medication: Levothyroxine sodium	0.7	1.3	3.8	-2.0	-0.1	-0.4	-1.2	-0.9
Sitting height	0.3	2.2	6.8	-1.6	0.9	-0.6	-2.6	-0.4
Chronic bronchitis/emphysema (father)	1.4	1.6	3.6	-0.6	-1.8	-1.9	0.2	0.9
High blood pressure (mother)	1.8	2.5	4.0	-2.0	-0.9	-1.9	-1.3	1.6
Body mass index (BMI)	0.2	0.7	1.5	0.2	0.1	-1.0	0.8	-1.2
Impedance of leg (left)	0.5	2.3	4.9	1.3	1.6	2.2	1.6	-0.2
Leg predicted mass (left)	0.3	1.6	4.9	-0.7	-0.1	-2.2	-1.1	-1.1
Trunk fat mass	0.1	0.5	1.1	0.4	0.5	-0.8	0.6	-1.1
Waist circumference	0.5	1.8	4.6	0.8	1.4	-1.1	0.8	-2.1
Number of incorrect matches in round	0.2	0.3	0.5	-0.7	-0.5	-0.1	-0.7	0.5
Past tobacco smoking	0.5	0.9	4.2	0.5	-0.4	2.1	-0.2	0.3
Alcohol usually taken with meals	1.6	2.5	6.6	-2.1	-1.3	0.1	-0.3	2.6
Nervous feelings	0.7	1.2	2.8	-0.9	-1.3	-1.7	-0.8	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.6	-0.6	-0.0	-1.6	-0.9	0.3
Hearing difficulty/problems with background noise	1.2	1.9	3.8	0.5	-2.0	1.4	1.0	1.4
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	-0.1	-1.3	-0.1	0.7	-0.8
Had menopause	0.7	0.8	1.9	-1.2	-0.1	0.0	0.9	1.4
Had other major operations	0.6	0.8	1.7	0.5	-0.9	-0.6	0.9	1.3
Forced vital capacity (FVC)	0.9	3.6	8.1	-1.9	1.4	1.9	-2.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	4.0	9.1	20.3	2.0	4.5	0.6	-0.8	-4.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.0	-0.2	-1.0	0.8	-0.6	0.5
Qualifications: None of the above	0.6	1.3	3.3	0.1	-0.5	-1.7	1.8	0.3
Financial difficulties in last 2 years	0.1	0.2	0.5	0.7	0.1	0.5	-0.1	-0.3
Mouth/teeth dental problems	3.2	4.8	7.1	2.7	1.8	1.6	2.3	-2.4
Heart attack	1.6	2.1	5.3	1.4	1.5	1.0	0.1	-2.3
Allergy	0.5	1.2	3.4	-1.1	0.3	-0.2	-1.8	-1.0
Pain all over the body in last month	0.8	0.8	2.1	0.8	0.9	0.2	1.5	-0.7
Diabetes (self-reported)	1.1	1.6	4.7	2.2	0.1	1.0	1.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.0	-0.1	0.6	0.8	-0.5
Medication: Ramipril	0.2	0.3	0.7	0.7	0.8	0.0	0.4	-0.4
Medication: Simvastatin	0.2	0.3	1.2	0.6	0.1	-0.0	-0.1	-1.1
Fluid intelligence score	0.4	0.7	1.7	-1.3	-0.3	-0.2	-1.2	0.6
Illnesses of siblings	0.1	0.2	0.4	-0.2	-0.4	-0.1	0.7	0.5
Neuroticism score	1.5	3.1	8.4	-1.6	-0.7	-1.9	-2.9	-0.2
Weight	0.2	1.0	2.6	-0.3	0.6	-1.6	-0.2	-1.5
Impedance of arm (right)	0.1	0.7	3.1	-0.5	0.2	0.1	-0.0	1.8
Arm fat percentage (right)	0.1	0.5	1.4	0.5	-0.1	-0.7	1.2	-0.6
Trunk fat-free mass	0.4	2.4	5.1	-0.6	0.7	-2.2	-1.5	-1.9
Hip circumference	0.1	0.4	1.6	0.1	0.1	-0.5	0.3	-1.3
Time employed in main current job	1.7	1.9	6.1	-1.3	-2.5	-0.1	-0.5	1.2
Alcohol intake versus 10 years previously	0.6	0.9	3.2	-0.2	1.8	-0.8	-0.2	-0.6
Father’s age at death	1.2	1.6	4.1	1.4	2.0	-0.3	0.9	-0.9
Worrier / anxious feelings	2.1	4.0	7.7	-2.0	-1.9	-2.8	-1.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.3	0.6	0.2	-0.1	0.0	0.1
Falls in the last year	1.6	2.2	5.6	-0.7	2.4	-0.4	-1.2	-1.8
Hair/balding pattern: Pattern 3	1.3	1.9	3.1	1.4	1.7	1.8	0.2	-1.2
Number of live births	0.9	1.3	4.2	0.9	1.1	0.1	2.1	-0.4
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	10.4	-0.4	2.4	3.2	-1.8	-2.6
Pulse rate	0.3	0.4	1.9	1.4	-0.3	0.3	0.2	0.1
Happiness	0.8	1.0	2.4	0.9	0.8	1.0	-0.2	-1.5
Noisy workplace	0.5	0.6	1.7	0.6	0.8	-0.7	1.3	0.1
Qualifications: A levels/AS levels or equivalent	1.1	2.5	5.0	-2.2	-1.7	1.4	-0.9	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.1	0.5	-0.1	1.5	-0.5	-0.0
Mouth/teeth dental problems: Dentures	0.9	1.5	3.3	-1.8	-0.5	0.7	-1.4	1.2
Asthma	0.5	1.0	3.9	0.4	-1.0	-0.0	0.1	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.9	-0.2	0.6	-2.0	-0.0	1.2
Medication: Cholesterol lowering	0.7	1.1	2.5	1.2	0.9	0.2	-0.8	-1.6
Depression (self-reported)	0.7	0.8	2.9	-0.3	-0.4	-1.7	-0.3	-1.0
Medication: Lansoprazole	0.3	0.3	0.8	0.3	-0.6	-0.9	-0.5	0.4
Prospective memory result	2.0	2.4	4.0	-2.0	-1.6	-1.5	-1.1	1.4
Lung cancer (father)	0.6	0.7	1.7	-0.1	1.3	0.2	-1.3	-0.4
Illnesses of mother	0.1	0.1	0.2	0.0	-0.3	0.5	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	12.5	-0.5	2.6	3.5	-1.4	-2.3
Pulse wave Arterial Stiffness index	4.1	4.8	17.2	4.1	1.0	1.2	2.0	-0.3
Impedance of arm (left)	0.2	0.8	3.1	-0.5	-0.1	0.8	-0.2	1.8
Arm fat mass (right)	0.1	0.5	1.3	0.1	0.2	-1.2	0.4	-1.1
Trunk predicted mass	0.4	2.3	5.3	-0.5	0.7	-2.3	-1.4	-1.9
Standing height	0.2	2.0	4.6	-1.2	1.1	-1.6	-2.1	-0.6
Length of working week for main job	0.9	0.9	2.3	-0.3	-1.0	-1.1	0.3	1.5
Exposure to tobacco smoke at home	0.4	0.4	1.4	0.2	-0.1	-1.2	-0.3	-0.8
Breastfed as a baby	0.7	0.9	1.8	1.1	0.0	1.0	1.3	-0.8
Tense / ‘highly strung’	0.8	1.4	2.9	-1.2	0.5	-1.4	-1.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.1	-1.3	-0.6	-1.8	0.7	0.1
Hair/balding pattern: Pattern 4	0.8	1.9	3.4	0.8	-0.4	-1.9	-1.4	-1.8
Birth weight of first child	0.5	0.8	1.7	-1.1	-0.1	1.1	-1.3	0.2
Peak expiratory flow (PEF)	2.2	5.1	8.6	-0.1	2.7	2.4	-1.9	-2.9
Pulse wave reflection index	5.0	6.2	13.6	3.7	2.0	1.6	3.2	-0.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.9	1.4	0.4	-0.1	0.3	-2.0
Loud music exposure frequency	0.7	0.7	3.5	-0.0	0.0	-1.9	-0.2	0.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	5.9	-0.5	0.7	2.4	-0.0	-1.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	-1.0	-0.7	-0.8	-1.0	1.2
Blood clot in the leg (DVT)	0.9	1.1	3.1	1.1	1.0	0.6	0.3	-1.8
Medication: Paracetamol	2.0	3.3	10.3	-1.7	-0.0	-3.2	-1.3	1.1
Headache pain in last month	4.8	8.2	20.6	-2.5	-1.8	-4.5	-1.8	2.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.0	-0.1	0.1	1.4	0.8	-0.1
Glaucoma (self-reported)	0.6	0.7	1.9	-0.5	-0.1	-1.4	-0.9	0.7
Gout (self-reported)	3.0	4.1	8.9	2.0	3.0	1.4	-0.0	-2.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.6	-1.0	0.3	1.0	-0.9	-1.9
Medication: Amlodipine	1.4	2.0	5.4	-0.7	0.5	-2.3	-0.9	1.8
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.8	0.0	0.5	-1.4	-0.2	0.8
Birth weight	1.2	2.6	5.2	-1.8	1.6	-0.8	-2.3	-1.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.7	0.7	0.4	0.3	1.9	-0.8
High blood pressure (siblings)	0.3	0.4	0.9	-0.9	0.6	-0.7	-0.7	0.2
Forced vital capacity (FVC), Best measure	1.1	4.0	7.9	-2.4	1.3	2.2	-2.8	-0.6
Body fat percentage	0.3	1.0	2.1	1.1	0.5	0.1	1.5	-1.2
Leg fat percentage (right)	0.8	2.8	4.4	2.1	1.1	0.7	1.9	-2.0
Arm fat-free mass (right)	0.4	1.9	5.3	0.1	0.9	-1.5	-0.9	-2.3
Exposure to tobacco smoke outside home	1.1	1.5	2.5	1.6	1.3	1.1	0.7	-1.3
Comparative body size at age 10	0.2	0.4	1.7	1.3	0.1	-0.3	0.5	-0.2
Number of full brothers	0.8	1.0	2.3	-0.1	-1.5	-0.9	1.2	0.6
Worry too long after embarrassment	1.1	1.8	2.9	-1.7	-1.5	-0.6	-1.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.3	0.2	-0.1	0.4	0.1
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	1.1	0.8	-0.2	1.2	0.5
Number of children fathered	1.7	1.9	6.4	-1.1	-0.2	-1.0	-2.5	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.9	-2.0	-0.6	-0.3	-1.6	0.0
Age at first live birth	2.4	4.3	6.3	-2.1	-2.5	0.0	-2.1	2.5
Pulse wave peak to peak time	4.4	5.2	18.0	-4.2	-1.1	-1.4	-2.2	0.3
Health satisfaction	0.4	0.5	2.0	-0.3	-0.6	-0.4	-1.4	0.0
Shortness of breath walking on level ground	0.7	0.9	2.8	-0.8	-0.9	0.2	-1.7	-0.3
Qualifications: College or University degree	0.1	0.4	0.8	-0.2	-0.7	0.8	-0.9	0.3
Eye problems/disorders: None of the above	0.1	0.2	0.6	0.1	-0.2	0.4	0.8	-0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	-0.2	0.3	0.9	-0.9	-1.1
Emphysema/chronic bronchitis	0.8	0.9	2.3	-0.4	-1.1	-0.8	0.3	1.5
Medication for pain relief, constipation, heartburn	0.7	1.1	3.0	0.8	0.3	1.7	1.0	-1.0
Neck or shoulder pain in last month	0.5	0.7	2.7	0.2	0.3	-1.6	-0.0	0.7
Medication: Blood pressure	0.8	1.4	2.1	-1.0	-1.1	-1.4	-0.9	1.5
Angina (self-reported)	0.4	0.5	1.5	1.2	0.6	0.8	0.3	-0.4
Migraine (self-reported)	0.9	1.1	2.8	-0.6	-1.1	-1.7	-0.3	1.1
Medication: Ibuprofen	1.6	1.9	5.9	-0.8	0.5	-2.4	-0.3	1.6
Medication: Allopurinol	2.9	3.9	8.4	1.5	2.9	2.0	-0.2	-2.2
Medication: Omeprazole	0.6	0.7	1.6	-1.3	-0.9	-0.2	-0.7	0.7
Medication: Seretide 50 evohaler	0.5	0.5	2.0	-0.1	0.7	-1.4	-0.5	0.0
Mean time to correctly identify matches	0.2	0.4	0.9	0.5	0.5	0.8	0.9	-0.3
Heart disease (mother)	0.3	0.4	1.3	0.5	-0.1	1.1	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	6.0	2.5	0.8	1.8	1.7	-1.0
Whole body fat mass	0.2	0.8	2.1	0.8	0.6	-0.5	0.9	-1.4
Leg fat mass (right)	0.4	1.7	4.3	1.3	0.9	-0.2	1.2	-2.1
Arm predicted mass (right)	0.4	2.0	5.0	0.0	1.0	-1.7	-0.8	-2.2
Pulse rate, automated reading	0.6	1.8	4.7	2.2	-0.9	1.1	1.5	0.1
Alcohol intake frequency.	0.2	0.6	1.3	-1.1	-0.6	-0.4	0.1	1.0
Comparative height size at age 10	0.5	2.8	9.1	-1.7	0.2	-1.4	-3.0	0.1
Number of full sisters	0.2	0.2	0.5	-0.0	0.1	-0.7	-0.7	-0.2
Suffer from ‘nerves’	0.5	0.8	3.3	-0.1	-0.0	-1.8	-0.5	-0.7
Overall health rating	0.8	1.8	3.6	1.9	1.0	0.3	1.4	-1.5
Chest pain or discomfort	0.3	0.4	0.8	-0.9	-0.8	-0.1	-0.3	0.8
Had major operations	0.2	0.3	0.7	0.6	0.2	0.2	0.8	-0.5
Age at last live birth	1.4	2.1	4.1	-1.4	-1.6	-0.4	-2.0	1.2
Family relationship satisfaction	0.7	0.9	1.6	-1.2	0.4	-1.3	-1.2	-0.3
Leg pain on walking	0.2	0.3	0.6	0.6	0.8	0.3	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	8.0	-0.4	-1.9	-1.8	0.2	2.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	-0.4	-0.2	-1.4	-1.0	0.5
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.9	-0.6	-2.2	-1.6	0.9	1.6
Medication: Aspirin	0.6	0.8	1.4	0.9	-1.2	1.2	0.5	-0.2
Supplements: Vitamin C	0.3	0.4	1.0	-0.8	0.2	-0.1	1.0	-0.5
Knee pain experienced in last month	0.6	0.9	2.5	-1.0	-1.6	0.4	-0.9	-0.0
Hypertension (Self-reported)	1.0	2.9	5.6	-1.1	-2.0	-1.8	-0.7	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.1	-0.3	0.0	-1.1	0.3	-0.2
Illnesses of father: Heart disease	1.5	2.1	4.0	-1.8	0.1	0.8	-2.0	1.7
Illnesses of siblings: Diabetes	0.5	0.6	2.1	-0.0	-0.8	-0.7	-1.5	0.1
Smoking status: Previous	0.6	0.9	4.1	-0.6	0.4	-2.0	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.0	0.4	1.1	-0.0	-1.4	-0.7
Whole body fat-free mass	0.3	2.0	4.8	-0.6	0.4	-2.2	-1.3	-1.8
Leg fat-free mass (right)	0.2	1.2	4.0	-0.7	-0.5	-2.0	-0.8	-1.0
Arm fat percentage (left)	0.1	0.5	1.0	0.6	-0.1	-0.6	1.0	-0.8
Average weekly red wine intake	1.1	1.6	3.5	0.7	-1.8	0.4	1.9	0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	-0.2	1.0	-1.4	-0.7	-0.1
Mood swings	1.9	3.4	7.0	-1.0	1.1	-2.7	-2.4	-1.4
Loneliness, isolation	1.4	1.9	4.3	-0.4	1.4	-2.1	-1.3	-1.3
Long-standing illness, disability or infirmity	0.4	0.6	1.4	1.1	0.7	0.0	0.4	-1.2
Ever had bowel cancer screening	0.3	0.4	0.8	-0.9	-0.4	-0.5	-0.9	-0.1
Diabetes diagnosed by doctor	0.8	1.4	4.5	2.1	-0.2	1.0	0.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.8	0.4	-0.1	-0.2	1.3	0.2
Friendships satisfaction	0.9	1.1	3.4	-0.8	-1.0	-0.3	-0.7	1.8
Qualifications: nursing, teaching	0.6	0.9	2.6	0.1	-0.3	1.3	-1.6	0.1
Commuting to job workplace: Walk	0.2	0.2	0.4	0.1	-0.1	0.6	-0.4	0.6
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.4	0.6	0.2	-0.9	-0.5
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	10.1	-1.1	-1.8	-3.2	-0.8	1.8
Medication for cholesterol	0.4	0.6	1.4	-1.2	0.5	-0.7	-1.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.0	6.9	-1.9	-1.6	1.4	-0.4	2.6
Back pain experienced in last month	0.2	0.3	1.3	0.1	-0.2	-1.1	0.2	0.4
Mineral and other dietary supplements	0.8	1.1	2.2	1.0	1.1	-0.7	0.7	-1.5
Breast cancer (self-reported)	0.2	0.2	0.5	0.5	0.7	0.1	0.5	-0.3
Asthma (self-reported)	0.6	1.1	4.4	0.4	-1.0	-0.3	0.3	2.1
Osteoporosis (self-reported)	1.0	1.2	2.9	-0.5	-1.1	-1.2	0.2	1.7
Osteoarthritis (self-reported)	0.9	1.2	2.8	1.7	0.1	0.6	1.0	-1.3
Medication: Aspirin	0.4	0.6	1.7	0.6	-1.3	0.8	-0.1	-0.2
Medication: Gliclazide	0.3	0.3	1.2	0.0	0.0	-0.1	0.5	1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.5	-0.8	-1.2	0.1	0.3
Smoking status: Current	0.4	0.7	1.6	1.3	-0.5	-0.1	1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	8.5	-0.6	1.8	2.9	-0.7	-1.5
Whole body water mass	0.4	2.0	4.7	-0.5	0.5	-2.2	-1.2	-1.8
Leg predicted mass (right)	0.2	1.3	4.2	-0.7	-0.4	-2.0	-0.8	-1.1
Arm fat mass (left)	0.2	0.8	1.6	0.4	0.4	-1.1	0.8	-1.3
Number of self-reported non-cancer illnesses	0.3	0.6	1.1	1.0	-1.1	-0.4	0.8	0.2
Average weekly champagne plus white wine intake	2.0	2.7	6.4	-0.4	1.9	-0.7	-2.5	-1.6
Miserableness	0.8	1.3	4.4	-0.5	0.7	-0.6	-2.1	-1.1
Guilty feelings	0.5	0.7	1.5	-0.7	-1.0	0.7	-1.2	-0.1
Wears glasses or contact lenses	0.5	0.6	1.3	0.8	-0.1	0.7	1.1	-0.8
Ever taken oral contraceptive pill	0.2	0.2	0.9	-1.0	-0.1	-0.0	-0.2	-0.3
Hearing aid user	1.2	1.4	3.2	1.8	1.4	0.4	0.6	-1.2
Mother’s age at death	0.3	0.4	1.3	-0.6	0.5	-1.1	-0.2	0.5
Financial situation satisfaction	0.5	0.6	2.3	1.5	-0.9	-0.1	0.1	0.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.7	-0.9	-0.5	-0.3	-0.2	1.6
Commuting to job workplace: Public transport	0.3	0.4	0.8	0.6	-0.4	0.3	0.7	-0.9
Eye problems/disorders: Glaucoma	4.0	4.8	7.8	-1.8	-2.3	-2.3	-1.5	2.8
Medication: Blood pressure	0.5	1.0	3.2	-0.1	-0.9	-0.3	0.8	1.8
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.0	-0.0	0.4	-0.2	-1.0	0.0
Supplements: Fish oil (including cod liver oil)	2.4	3.1	6.2	-2.1	-1.7	-0.4	-1.4	2.5
High cholesterol (Self-reported)	0.6	1.1	3.8	1.0	0.7	0.1	-0.4	-2.0
Medication: Bendroflumethiazide	0.4	0.6	0.9	0.7	-1.0	0.8	0.9	-0.1
Medication: Paracetamol	2.3	3.5	10.8	-1.6	0.7	-3.3	-1.7	1.0
Medication: Lisinopril	0.2	0.2	0.7	0.7	-0.1	0.8	0.0	0.1
Medication: Atorvastatin	1.3	1.6	3.2	1.8	1.3	0.5	1.1	-1.4
Illnesses of father: High blood pressure	0.3	0.4	1.1	-0.4	0.4	-1.1	-0.6	-0.2
Alcohol drinker status: Never	0.5	0.5	2.6	-0.3	0.1	0.2	-1.6	0.1
Ever smoked	0.8	1.3	4.9	-0.8	0.7	-2.2	-0.1	-0.8
Basal metabolic rate	0.3	1.8	4.5	-0.4	0.5	-2.1	-1.0	-1.8
Leg fat percentage (left)	0.8	2.8	5.2	2.0	1.0	0.6	2.3	-1.8
Arm fat-free mass (left)	0.3	1.6	3.9	-0.1	0.8	-1.8	-0.5	-2.0
Number of operations (self-reported)	0.2	0.3	0.6	0.7	0.8	-0.1	0.5	-0.2
Average weekly beer plus cider intake	1.3	2.0	6.3	-1.7	0.1	-0.6	-2.5	0.5
Irritability	0.8	1.4	3.3	1.2	0.8	-1.1	-0.6	-1.8
Risk taking	0.1	0.2	0.7	0.4	0.9	-0.4	-0.2	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	-1.0	-0.2	0.3	-0.3	0.2
Fractured/broken bones in last 5 years	0.4	0.6	1.3	-1.1	-0.8	-0.4	-0.6	0.7
Age started oral contraceptive pill	0.4	0.5	0.9	-0.2	0.8	-0.9	0.4	0.9
Diastolic blood pressure, automated reading	0.4	1.1	2.3	-0.8	1.5	-1.0	-1.1	-0.5
Ever depressed for a whole week	1.2	1.5	3.9	2.0	-0.9	1.0	1.3	0.1
Unable to work because of sickness or disability	2.6	3.4	4.8	1.9	2.2	1.1	1.5	-2.2
Commuting to job workplace: Cycle	1.0	1.2	4.5	0.9	-2.1	0.6	0.6	0.4
Myopia	0.5	0.7	2.2	0.2	-0.4	1.5	0.9	0.4
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.9	0.2	1.2	1.0	0.1	-1.4
Cholesterol lowering medication	1.1	1.6	2.7	1.6	-0.1	1.3	1.6	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	3.0	-1.7	-1.3	-0.9	-1.2	0.9
Pain experienced in last month	0.6	0.9	2.1	0.9	0.3	1.3	0.1	-1.5
Supplements: Calcium	0.9	1.0	3.1	-0.4	-0.9	0.6	0.8	1.8
Basal cell carcinoma (self-reported)	0.1	0.2	0.2	-0.4	0.5	-0.4	0.5	-0.0
Heart attack/myocardial infarction (self-reported)	1.6	2.0	4.8	1.5	1.3	1.1	0.2	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.1	1.5	0.9	0.9	0.9	-2.0
Heart disease (siblings)	0.4	0.5	1.8	0.4	0.7	0.4	1.3	-0.2
Alcohol drinker status: Previous	0.4	0.4	1.2	-1.1	0.1	0.6	0.1	-0.8
Pack years of smoking	4.9	7.2	11.0	3.3	3.1	1.1	2.3	-3.0
Impedance of whole body	0.2	1.0	2.5	0.7	1.0	1.6	0.6	0.7
Leg fat mass (left)	0.4	1.6	3.1	1.3	0.8	-0.3	1.5	-1.8
Arm predicted mass (left)	0.3	1.4	3.7	-0.1	0.7	-1.6	-0.5	-1.9