Hub : Genes

SNCAIP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0530 0.0260 0.01200 0.024 0.017 0.028 0.021 0.024 0.00056 3.1e-03 2.2e-04 1.2e-03 5.2e-04
2 GTEx Brain Cerebellum 0.2750 0.0780 0.00017 -0.009 NA 0.026 NA 0.019 0.78000 NA 5.6e-02 NA 8.7e-02
3 METSIM Adipose 0.0433 0.0217 0.00590 0.000 0.008 0.006 0.008 0.004 0.35000 2.2e-02 3.7e-02 1.8e-02 7.7e-02
4 ROSMAP Brain Pre-frontal Cortex 0.0987 0.0321 0.00013 0.025 0.033 0.064 0.052 0.053 0.00030 3.4e-05 1.1e-08 2.8e-07 2.3e-07
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0399 0.0242 0.00400 0.000 0.008 -0.001 NA 0.003 0.28000 3.5e-02 4.0e-01 NA 1.5e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.2 1.9 4.5 1.0 1.6 -0.5 1.3 -2.1
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 0.1 -0.4 -0.9 0.9 0.2
Depressed Affect (Nagel 2018) 1.5 3.1 5.5 -0.3 1.8 -1.3 -2.4 -2.1
Depression (Nagel 2018) 0.3 0.4 0.8 0.7 0.4 0.8 -0.1 -0.9
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.6 -0.8 0.1 0.5 0.1 0.3
Neuroticism (Nagel 2018) 0.8 1.8 4.2 -0.7 0.4 -1.2 -2.0 -1.7
Schizophrenia (2018) 0.8 1.7 4.1 -0.7 -1.9 -0.7 0.1 2.0
Schizophrenia vs Biploar Disorder 2.1 2.7 4.7 -1.3 -1.9 -1.1 -1.6 2.2
Worry (Nagel 2018) 1.2 2.4 4.2 -1.8 -0.9 -2.0 -2.0 0.3
Alzheimer’s Disease (in mother) 0.3 0.3 1.0 -0.3 0.5 1.0 0.6 -0.1
Alzheimer’s Disease (in father) 0.2 0.3 0.7 -0.5 -0.8 0.4 -0.1 0.4
Alzheimer’s Disease (including proxy) 0.2 0.3 1.1 -0.3 0.2 1.1 0.4 -0.3
Crohns Disease (2017) 0.3 0.6 1.9 -0.1 1.4 -0.8 -0.1 -0.6
Irritable Bowel Disease (IBD) 0.4 1.0 2.9 -0.8 0.3 -1.7 -1.2 -0.0
Ulcerative Colitis (UC) 1.0 1.9 3.1 -1.6 -0.8 -1.6 -1.8 0.6
Major Depression (MDD) 2.1 2.5 5.8 -0.8 -1.8 -1.4 1.0 2.4
Reaction Time 0.5 0.9 1.3 0.6 1.1 1.0 1.0 -0.9
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.6 -0.2 -0.8 0.7 0.2 0.2
Breast Cancer 2.1 5.2 15.8 1.6 2.0 1.9 -0.2 -4.0
Ovarian Cancer 0.5 0.6 1.9 0.7 0.6 0.5 0.2 -1.4
Prostate Cancer 0.4 0.5 1.9 -0.3 -0.4 -0.5 -0.6 1.4
Age at First Birth 0.2 0.3 0.5 -0.7 -0.6 0.6 0.2 0.6
Bipolar Disorder (2011) 1.2 1.1 2.5 0.9 1.6 0.6 0.4 -1.4
Body Mass Index (BMI) (2010) 0.8 1.1 2.8 -1.0 -1.2 -1.7 -0.7 0.1
Coronary Artery Disease (CAD) 0.4 0.4 1.1 0.6 1.0 -0.6 -0.6 0.1
Crohns Disease (2012) 0.2 0.3 0.8 -0.9 -0.1 -0.6 -0.3 0.3
Mean Putamen Volume 0.3 0.3 0.7 -0.3 0.5 -0.9 -0.4 -0.4
Fasting Glucose 1.1 1.3 3.4 -0.8 0.8 -1.9 0.3 -1.3
HbA1C 2.7 3.0 6.0 -1.8 -1.2 -1.9 -2.4 0.8
HDL Cholesterol 0.6 1.0 3.0 1.2 -0.1 -0.7 1.7 -0.2
LDL Cholesterol 0.6 1.0 3.0 -0.0 0.7 0.5 -1.7 -1.1
Lupus 0.4 0.6 1.9 0.1 -1.4 -0.3 0.6 0.7
Neuroticism (2016) 1.7 2.4 3.4 -1.8 -1.6 -1.9 -1.3 1.1
Primary Biliary Cirrhosis 0.3 0.4 0.9 0.4 -0.0 -0.7 1.0 0.6
Rheumatoid Arthritis 0.4 0.6 1.4 0.4 -0.9 -1.2 0.5 0.4
Schizophrenia (2014) 1.0 2.2 5.7 -0.2 -2.0 -0.6 1.1 2.4
Triglycerides 1.2 1.9 5.8 -1.9 -0.0 0.2 -2.4 0.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.8 0.5 0.9 -1.1 0.6 -1.4
Ulcerative Colitis 3.2 4.7 7.0 -2.1 -2.6 -2.0 -1.7 2.3
Blood Eosinophil Count 0.1 0.8 2.0 1.2 -0.4 -0.5 1.4 -0.1
Blood Platelet Count 0.1 1.3 3.8 0.9 -0.6 -1.0 -0.6 -1.9
Blood Red Count 0.1 0.6 1.3 1.2 0.7 0.9 0.4 -0.6
Blood White Count 0.4 2.9 4.7 2.1 -0.8 -2.2 1.0 -1.8
Heel T-Score 1.2 9.8 26.4 1.6 5.1 1.5 -1.2 -4.1
BMI 0.2 1.0 2.8 0.7 0.2 -0.9 1.0 -1.7
Height 0.3 5.6 10.1 -0.2 2.7 -3.2 -2.6 -1.9
Waist Hip Ratio (WHR) 0.4 2.0 4.2 1.5 1.8 -2.0 0.3 -0.6
Systolic Blood Pressure 1.5 7.6 17.1 -2.9 0.2 -4.1 -3.5 0.0
Smoking Status 0.2 0.4 1.6 -0.2 -0.2 -1.3 0.7 -0.1
Allergy or Eczema 1.0 2.6 6.7 0.1 -1.6 -0.1 2.6 1.9
Cardiovascular Disease 0.2 0.6 2.0 -0.3 -0.4 -1.0 -1.4 0.2
Hypothyroidism (self reported) 0.3 0.7 1.4 -0.9 0.0 1.2 -0.7 -1.0
Respiratory disease 0.7 1.5 6.3 -0.5 -0.4 -0.7 -0.3 2.5
Type 2 Diabetes (T2D) (2018) 0.7 1.2 3.6 1.9 -0.8 1.3 0.2 -0.6
Lung FEV1/FVC ratio 3.8 19.1 32.0 4.5 4.1 4.3 2.7 -5.7
Lung FVC 1.2 6.1 11.7 -1.9 2.1 3.4 -2.9 -1.7
Neuroticism 1.2 3.0 7.0 -1.7 -0.8 -2.1 -2.6 0.2
Chronotype (morning person) 1.9 4.4 6.8 -2.3 -1.0 -2.5 -2.6 1.5
Hair Pigment 0.1 2.5 5.1 1.7 -1.6 2.2 1.4 -0.4
Tanning 0.3 3.4 4.9 -2.1 -1.1 -2.2 -2.2 1.2
Hand grip strength (left) 0.6 1.7 4.8 -2.2 -0.3 -1.1 -1.2 1.0
Number of treatments/medications taken 1.1 1.9 4.3 -0.9 -1.4 -2.1 -0.7 1.4
Average weekly spirits intake 0.7 0.9 2.1 0.4 -1.2 0.8 1.5 0.1
Sensitivity / hurt feelings 0.5 0.8 1.7 -1.3 -0.4 -0.6 -1.0 -0.7
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.6 1.3 -0.2 0.2 -0.1 -0.9
Hearing difficulty/problems: Yes 0.8 1.2 3.3 1.8 1.1 0.2 1.0 -0.6
Relative age of first facial hair 0.4 0.9 2.0 -0.7 -1.0 -0.1 0.9 1.4
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 4.3 2.1 0.4 1.1 1.6 -0.7
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.9 -0.0 -0.1 0.7 1.4 0.1
Ever had hysterectomy (womb removed) 0.9 1.1 2.7 -1.6 -0.0 -0.8 -1.4 0.1
Systolic blood pressure, automated reading 1.4 4.2 9.2 -2.2 0.7 -3.0 -2.5 -0.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.9 1.0 0.2 -0.1 0.0 -0.3
Angina 0.3 0.4 1.1 1.1 0.3 0.7 0.5 -0.1
Medication for hormone replacement therapy 1.4 1.5 3.2 1.2 0.0 1.8 1.7 -0.4
Vitamin and mineral supplements 0.6 0.8 1.1 1.0 -1.0 -0.2 1.0 0.9
Supplements: Zinc 0.8 0.9 1.7 1.3 0.7 0.7 1.1 -0.8
Medication: Co-codamol 1.9 2.2 5.8 -1.2 -1.2 -2.4 -0.8 1.3
Medication: Metformin 0.3 0.4 0.6 0.6 -0.2 0.6 -0.8 -0.8
Diabetes (father) 0.3 0.4 0.8 -0.6 -0.9 0.3 0.4 0.8
Diabetes (mother) 1.3 1.6 3.3 1.2 0.9 -1.8 0.4 -1.5
Severe depression (siblings) 0.1 0.1 0.5 0.7 0.1 -0.0 0.0 0.2
Pack years adult smoking proportion 4.2 6.5 10.2 3.2 3.0 0.7 1.7 -3.1
Impedance of leg (right) 0.4 1.7 4.0 1.1 1.6 2.0 0.9 -0.2
Leg fat-free mass (left) 0.3 1.5 4.7 -0.7 -0.2 -2.2 -1.1 -1.1
Trunk fat percentage 0.1 0.4 1.1 0.5 0.2 -0.2 1.1 -0.6
Hand grip strength (right) 0.5 1.2 4.3 -2.1 -0.2 -0.4 -0.7 1.1
Townsend deprivation index at recruitment 0.8 1.1 3.0 0.5 1.2 -0.5 0.7 -1.7
Current tobacco smoking 0.4 0.7 1.4 1.1 -0.4 -0.4 1.2 -0.7
Average weekly fortified wine intake 0.5 0.6 1.6 0.7 1.3 -0.3 0.7 -0.7
Maternal smoking around birth 1.2 1.7 3.8 -1.8 -0.5 -2.0 -0.8 0.6
Fed-up feelings 1.4 2.5 6.7 -0.7 0.3 -2.1 -2.6 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.5 0.6 0.2 0.1 -0.5 -1.2
Relative age voice broke 0.3 0.5 1.0 0.9 -1.0 -0.0 0.8 -0.0
Taking other prescription medications 0.4 0.7 2.7 -0.2 -0.8 -1.6 -0.2 -0.1
Age when periods started (menarche) 0.8 2.0 8.4 0.6 -0.1 -2.9 1.2 -0.2
Bilateral oophorectomy (both ovaries removed) 2.1 2.5 5.7 0.2 2.4 0.7 -1.0 -2.3
Heel bone mineral density (BMD) T-score, automated (left) 2.1 4.7 10.5 1.6 3.2 0.4 -0.2 -3.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.4 1.2 0.7 0.8 0.7 -0.1
Qualifications: CSEs or equivalent 3.4 4.4 10.3 1.6 1.9 2.3 -0.6 -3.2
Serious illness, injury or assault to yourself 2.7 3.2 6.5 0.6 2.1 1.6 -1.5 -2.5
High blood pressure 0.8 2.4 4.8 -0.9 -1.8 -1.7 -0.5 2.2
Hayfever, allergic rhinitis or eczema 1.0 2.1 4.2 0.2 -1.6 0.2 2.1 1.9
Multivitamins +/- minerals 0.5 0.7 2.1 -0.7 0.6 0.1 -1.4 -0.8
Stomach or abdominal pain in last month 1.0 1.2 3.1 -1.0 -1.2 0.4 -0.2 1.8
Supplements: Glucosamine 1.1 1.4 5.9 0.1 0.8 2.4 -0.7 -0.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.2 -0.8 -0.8 -1.1 0.1 1.1
Medication: Atenolol 0.4 0.5 0.6 0.7 -0.7 -0.6 0.6 0.7
Medication: Levothyroxine sodium 0.7 1.3 3.8 -2.0 -0.1 -0.4 -1.2 -0.9
Sitting height 0.3 2.2 6.8 -1.6 0.9 -0.6 -2.6 -0.4
Chronic bronchitis/emphysema (father) 1.4 1.6 3.6 -0.6 -1.8 -1.9 0.2 0.9
High blood pressure (mother) 1.8 2.5 4.0 -2.0 -0.9 -1.9 -1.3 1.6
Body mass index (BMI) 0.2 0.7 1.5 0.2 0.1 -1.0 0.8 -1.2
Impedance of leg (left) 0.5 2.3 4.9 1.3 1.6 2.2 1.6 -0.2
Leg predicted mass (left) 0.3 1.6 4.9 -0.7 -0.1 -2.2 -1.1 -1.1
Trunk fat mass 0.1 0.5 1.1 0.4 0.5 -0.8 0.6 -1.1
Waist circumference 0.5 1.8 4.6 0.8 1.4 -1.1 0.8 -2.1
Number of incorrect matches in round 0.2 0.3 0.5 -0.7 -0.5 -0.1 -0.7 0.5
Past tobacco smoking 0.5 0.9 4.2 0.5 -0.4 2.1 -0.2 0.3
Alcohol usually taken with meals 1.6 2.5 6.6 -2.1 -1.3 0.1 -0.3 2.6
Nervous feelings 0.7 1.2 2.8 -0.9 -1.3 -1.7 -0.8 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.6 -0.6 -0.0 -1.6 -0.9 0.3
Hearing difficulty/problems with background noise 1.2 1.9 3.8 0.5 -2.0 1.4 1.0 1.4
Hair/balding pattern: Pattern 2 0.5 0.6 1.8 -0.1 -1.3 -0.1 0.7 -0.8
Had menopause 0.7 0.8 1.9 -1.2 -0.1 0.0 0.9 1.4
Had other major operations 0.6 0.8 1.7 0.5 -0.9 -0.6 0.9 1.3
Forced vital capacity (FVC) 0.9 3.6 8.1 -1.9 1.4 1.9 -2.8 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 4.0 9.1 20.3 2.0 4.5 0.6 -0.8 -4.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.0 -0.2 -1.0 0.8 -0.6 0.5
Qualifications: None of the above 0.6 1.3 3.3 0.1 -0.5 -1.7 1.8 0.3
Financial difficulties in last 2 years 0.1 0.2 0.5 0.7 0.1 0.5 -0.1 -0.3
Mouth/teeth dental problems 3.2 4.8 7.1 2.7 1.8 1.6 2.3 -2.4
Heart attack 1.6 2.1 5.3 1.4 1.5 1.0 0.1 -2.3
Allergy 0.5 1.2 3.4 -1.1 0.3 -0.2 -1.8 -1.0
Pain all over the body in last month 0.8 0.8 2.1 0.8 0.9 0.2 1.5 -0.7
Diabetes (self-reported) 1.1 1.6 4.7 2.2 0.1 1.0 1.2 -1.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.7 -0.0 -0.1 0.6 0.8 -0.5
Medication: Ramipril 0.2 0.3 0.7 0.7 0.8 0.0 0.4 -0.4
Medication: Simvastatin 0.2 0.3 1.2 0.6 0.1 -0.0 -0.1 -1.1
Fluid intelligence score 0.4 0.7 1.7 -1.3 -0.3 -0.2 -1.2 0.6
Illnesses of siblings 0.1 0.2 0.4 -0.2 -0.4 -0.1 0.7 0.5
Neuroticism score 1.5 3.1 8.4 -1.6 -0.7 -1.9 -2.9 -0.2
Weight 0.2 1.0 2.6 -0.3 0.6 -1.6 -0.2 -1.5
Impedance of arm (right) 0.1 0.7 3.1 -0.5 0.2 0.1 -0.0 1.8
Arm fat percentage (right) 0.1 0.5 1.4 0.5 -0.1 -0.7 1.2 -0.6
Trunk fat-free mass 0.4 2.4 5.1 -0.6 0.7 -2.2 -1.5 -1.9
Hip circumference 0.1 0.4 1.6 0.1 0.1 -0.5 0.3 -1.3
Time employed in main current job 1.7 1.9 6.1 -1.3 -2.5 -0.1 -0.5 1.2
Alcohol intake versus 10 years previously 0.6 0.9 3.2 -0.2 1.8 -0.8 -0.2 -0.6
Father’s age at death 1.2 1.6 4.1 1.4 2.0 -0.3 0.9 -0.9
Worrier / anxious feelings 2.1 4.0 7.7 -2.0 -1.9 -2.8 -1.8 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.3 0.6 0.2 -0.1 0.0 0.1
Falls in the last year 1.6 2.2 5.6 -0.7 2.4 -0.4 -1.2 -1.8
Hair/balding pattern: Pattern 3 1.3 1.9 3.1 1.4 1.7 1.8 0.2 -1.2
Number of live births 0.9 1.3 4.2 0.9 1.1 0.1 2.1 -0.4
Forced expiratory volume in 1-second (FEV1) 1.5 5.2 10.4 -0.4 2.4 3.2 -1.8 -2.6
Pulse rate 0.3 0.4 1.9 1.4 -0.3 0.3 0.2 0.1
Happiness 0.8 1.0 2.4 0.9 0.8 1.0 -0.2 -1.5
Noisy workplace 0.5 0.6 1.7 0.6 0.8 -0.7 1.3 0.1
Qualifications: A levels/AS levels or equivalent 1.1 2.5 5.0 -2.2 -1.7 1.4 -0.9 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 2.1 0.5 -0.1 1.5 -0.5 -0.0
Mouth/teeth dental problems: Dentures 0.9 1.5 3.3 -1.8 -0.5 0.7 -1.4 1.2
Asthma 0.5 1.0 3.9 0.4 -1.0 -0.0 0.1 2.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.9 -0.2 0.6 -2.0 -0.0 1.2
Medication: Cholesterol lowering 0.7 1.1 2.5 1.2 0.9 0.2 -0.8 -1.6
Depression (self-reported) 0.7 0.8 2.9 -0.3 -0.4 -1.7 -0.3 -1.0
Medication: Lansoprazole 0.3 0.3 0.8 0.3 -0.6 -0.9 -0.5 0.4
Prospective memory result 2.0 2.4 4.0 -2.0 -1.6 -1.5 -1.1 1.4
Lung cancer (father) 0.6 0.7 1.7 -0.1 1.3 0.2 -1.3 -0.4
Illnesses of mother 0.1 0.1 0.2 0.0 -0.3 0.5 -0.4 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.4 12.5 -0.5 2.6 3.5 -1.4 -2.3
Pulse wave Arterial Stiffness index 4.1 4.8 17.2 4.1 1.0 1.2 2.0 -0.3
Impedance of arm (left) 0.2 0.8 3.1 -0.5 -0.1 0.8 -0.2 1.8
Arm fat mass (right) 0.1 0.5 1.3 0.1 0.2 -1.2 0.4 -1.1
Trunk predicted mass 0.4 2.3 5.3 -0.5 0.7 -2.3 -1.4 -1.9
Standing height 0.2 2.0 4.6 -1.2 1.1 -1.6 -2.1 -0.6
Length of working week for main job 0.9 0.9 2.3 -0.3 -1.0 -1.1 0.3 1.5
Exposure to tobacco smoke at home 0.4 0.4 1.4 0.2 -0.1 -1.2 -0.3 -0.8
Breastfed as a baby 0.7 0.9 1.8 1.1 0.0 1.0 1.3 -0.8
Tense / ‘highly strung’ 0.8 1.4 2.9 -1.2 0.5 -1.4 -1.7 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.1 -1.3 -0.6 -1.8 0.7 0.1
Hair/balding pattern: Pattern 4 0.8 1.9 3.4 0.8 -0.4 -1.9 -1.4 -1.8
Birth weight of first child 0.5 0.8 1.7 -1.1 -0.1 1.1 -1.3 0.2
Peak expiratory flow (PEF) 2.2 5.1 8.6 -0.1 2.7 2.4 -1.9 -2.9
Pulse wave reflection index 5.0 6.2 13.6 3.7 2.0 1.6 3.2 -0.9
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.9 1.4 0.4 -0.1 0.3 -2.0
Loud music exposure frequency 0.7 0.7 3.5 -0.0 0.0 -1.9 -0.2 0.0
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 5.9 -0.5 0.7 2.4 -0.0 -1.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.5 -1.0 -0.7 -0.8 -1.0 1.2
Blood clot in the leg (DVT) 0.9 1.1 3.1 1.1 1.0 0.6 0.3 -1.8
Medication: Paracetamol 2.0 3.3 10.3 -1.7 -0.0 -3.2 -1.3 1.1
Headache pain in last month 4.8 8.2 20.6 -2.5 -1.8 -4.5 -1.8 2.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.0 -0.1 0.1 1.4 0.8 -0.1
Glaucoma (self-reported) 0.6 0.7 1.9 -0.5 -0.1 -1.4 -0.9 0.7
Gout (self-reported) 3.0 4.1 8.9 2.0 3.0 1.4 -0.0 -2.5
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 3.6 -1.0 0.3 1.0 -0.9 -1.9
Medication: Amlodipine 1.4 2.0 5.4 -0.7 0.5 -2.3 -0.9 1.8
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.8 0.0 0.5 -1.4 -0.2 0.8
Birth weight 1.2 2.6 5.2 -1.8 1.6 -0.8 -2.3 -1.2
Chronic bronchitis/emphysema (mother) 0.9 1.0 3.7 0.7 0.4 0.3 1.9 -0.8
High blood pressure (siblings) 0.3 0.4 0.9 -0.9 0.6 -0.7 -0.7 0.2
Forced vital capacity (FVC), Best measure 1.1 4.0 7.9 -2.4 1.3 2.2 -2.8 -0.6
Body fat percentage 0.3 1.0 2.1 1.1 0.5 0.1 1.5 -1.2
Leg fat percentage (right) 0.8 2.8 4.4 2.1 1.1 0.7 1.9 -2.0
Arm fat-free mass (right) 0.4 1.9 5.3 0.1 0.9 -1.5 -0.9 -2.3
Exposure to tobacco smoke outside home 1.1 1.5 2.5 1.6 1.3 1.1 0.7 -1.3
Comparative body size at age 10 0.2 0.4 1.7 1.3 0.1 -0.3 0.5 -0.2
Number of full brothers 0.8 1.0 2.3 -0.1 -1.5 -0.9 1.2 0.6
Worry too long after embarrassment 1.1 1.8 2.9 -1.7 -1.5 -0.6 -1.7 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.1 0.1 -0.3 0.2 -0.1 0.4 0.1
Wheeze or whistling in the chest in last year 0.4 0.7 1.5 1.1 0.8 -0.2 1.2 0.5
Number of children fathered 1.7 1.9 6.4 -1.1 -0.2 -1.0 -2.5 1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.9 -2.0 -0.6 -0.3 -1.6 0.0
Age at first live birth 2.4 4.3 6.3 -2.1 -2.5 0.0 -2.1 2.5
Pulse wave peak to peak time 4.4 5.2 18.0 -4.2 -1.1 -1.4 -2.2 0.3
Health satisfaction 0.4 0.5 2.0 -0.3 -0.6 -0.4 -1.4 0.0
Shortness of breath walking on level ground 0.7 0.9 2.8 -0.8 -0.9 0.2 -1.7 -0.3
Qualifications: College or University degree 0.1 0.4 0.8 -0.2 -0.7 0.8 -0.9 0.3
Eye problems/disorders: None of the above 0.1 0.2 0.6 0.1 -0.2 0.4 0.8 -0.0
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.3 -0.2 0.3 0.9 -0.9 -1.1
Emphysema/chronic bronchitis 0.8 0.9 2.3 -0.4 -1.1 -0.8 0.3 1.5
Medication for pain relief, constipation, heartburn 0.7 1.1 3.0 0.8 0.3 1.7 1.0 -1.0
Neck or shoulder pain in last month 0.5 0.7 2.7 0.2 0.3 -1.6 -0.0 0.7
Medication: Blood pressure 0.8 1.4 2.1 -1.0 -1.1 -1.4 -0.9 1.5
Angina (self-reported) 0.4 0.5 1.5 1.2 0.6 0.8 0.3 -0.4
Migraine (self-reported) 0.9 1.1 2.8 -0.6 -1.1 -1.7 -0.3 1.1
Medication: Ibuprofen 1.6 1.9 5.9 -0.8 0.5 -2.4 -0.3 1.6
Medication: Allopurinol 2.9 3.9 8.4 1.5 2.9 2.0 -0.2 -2.2
Medication: Omeprazole 0.6 0.7 1.6 -1.3 -0.9 -0.2 -0.7 0.7
Medication: Seretide 50 evohaler 0.5 0.5 2.0 -0.1 0.7 -1.4 -0.5 0.0
Mean time to correctly identify matches 0.2 0.4 0.9 0.5 0.5 0.8 0.9 -0.3
Heart disease (mother) 0.3 0.4 1.3 0.5 -0.1 1.1 -0.2 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.7 6.0 2.5 0.8 1.8 1.7 -1.0
Whole body fat mass 0.2 0.8 2.1 0.8 0.6 -0.5 0.9 -1.4
Leg fat mass (right) 0.4 1.7 4.3 1.3 0.9 -0.2 1.2 -2.1
Arm predicted mass (right) 0.4 2.0 5.0 0.0 1.0 -1.7 -0.8 -2.2
Pulse rate, automated reading 0.6 1.8 4.7 2.2 -0.9 1.1 1.5 0.1
Alcohol intake frequency. 0.2 0.6 1.3 -1.1 -0.6 -0.4 0.1 1.0
Comparative height size at age 10 0.5 2.8 9.1 -1.7 0.2 -1.4 -3.0 0.1
Number of full sisters 0.2 0.2 0.5 -0.0 0.1 -0.7 -0.7 -0.2
Suffer from ‘nerves’ 0.5 0.8 3.3 -0.1 -0.0 -1.8 -0.5 -0.7
Overall health rating 0.8 1.8 3.6 1.9 1.0 0.3 1.4 -1.5
Chest pain or discomfort 0.3 0.4 0.8 -0.9 -0.8 -0.1 -0.3 0.8
Had major operations 0.2 0.3 0.7 0.6 0.2 0.2 0.8 -0.5
Age at last live birth 1.4 2.1 4.1 -1.4 -1.6 -0.4 -2.0 1.2
Family relationship satisfaction 0.7 0.9 1.6 -1.2 0.4 -1.3 -1.2 -0.3
Leg pain on walking 0.2 0.3 0.6 0.6 0.8 0.3 -0.1 -0.4
Qualifications: NVQ or HND or HNC or equivalent 2.5 3.0 8.0 -0.4 -1.9 -1.8 0.2 2.8
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.9 -0.4 -0.2 -1.4 -1.0 0.5
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 4.9 -0.6 -2.2 -1.6 0.9 1.6
Medication: Aspirin 0.6 0.8 1.4 0.9 -1.2 1.2 0.5 -0.2
Supplements: Vitamin C 0.3 0.4 1.0 -0.8 0.2 -0.1 1.0 -0.5
Knee pain experienced in last month 0.6 0.9 2.5 -1.0 -1.6 0.4 -0.9 -0.0
Hypertension (Self-reported) 1.0 2.9 5.6 -1.1 -2.0 -1.8 -0.7 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.1 -0.3 0.0 -1.1 0.3 -0.2
Illnesses of father: Heart disease 1.5 2.1 4.0 -1.8 0.1 0.8 -2.0 1.7
Illnesses of siblings: Diabetes 0.5 0.6 2.1 -0.0 -0.8 -0.7 -1.5 0.1
Smoking status: Previous 0.6 0.9 4.1 -0.6 0.4 -2.0 0.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.0 0.4 1.1 -0.0 -1.4 -0.7
Whole body fat-free mass 0.3 2.0 4.8 -0.6 0.4 -2.2 -1.3 -1.8
Leg fat-free mass (right) 0.2 1.2 4.0 -0.7 -0.5 -2.0 -0.8 -1.0
Arm fat percentage (left) 0.1 0.5 1.0 0.6 -0.1 -0.6 1.0 -0.8
Average weekly red wine intake 1.1 1.6 3.5 0.7 -1.8 0.4 1.9 0.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.0 -0.2 1.0 -1.4 -0.7 -0.1
Mood swings 1.9 3.4 7.0 -1.0 1.1 -2.7 -2.4 -1.4
Loneliness, isolation 1.4 1.9 4.3 -0.4 1.4 -2.1 -1.3 -1.3
Long-standing illness, disability or infirmity 0.4 0.6 1.4 1.1 0.7 0.0 0.4 -1.2
Ever had bowel cancer screening 0.3 0.4 0.8 -0.9 -0.4 -0.5 -0.9 -0.1
Diabetes diagnosed by doctor 0.8 1.4 4.5 2.1 -0.2 1.0 0.8 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.8 0.4 -0.1 -0.2 1.3 0.2
Friendships satisfaction 0.9 1.1 3.4 -0.8 -1.0 -0.3 -0.7 1.8
Qualifications: nursing, teaching 0.6 0.9 2.6 0.1 -0.3 1.3 -1.6 0.1
Commuting to job workplace: Walk 0.2 0.2 0.4 0.1 -0.1 0.6 -0.4 0.6
Eye problems/disorders: Cataract 0.3 0.3 0.7 0.4 0.6 0.2 -0.9 -0.5
Mouth/teeth dental problems: Mouth ulcers 2.3 3.7 10.1 -1.1 -1.8 -3.2 -0.8 1.8
Medication for cholesterol 0.4 0.6 1.4 -1.2 0.5 -0.7 -1.0 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.6 3.0 6.9 -1.9 -1.6 1.4 -0.4 2.6
Back pain experienced in last month 0.2 0.3 1.3 0.1 -0.2 -1.1 0.2 0.4
Mineral and other dietary supplements 0.8 1.1 2.2 1.0 1.1 -0.7 0.7 -1.5
Breast cancer (self-reported) 0.2 0.2 0.5 0.5 0.7 0.1 0.5 -0.3
Asthma (self-reported) 0.6 1.1 4.4 0.4 -1.0 -0.3 0.3 2.1
Osteoporosis (self-reported) 1.0 1.2 2.9 -0.5 -1.1 -1.2 0.2 1.7
Osteoarthritis (self-reported) 0.9 1.2 2.8 1.7 0.1 0.6 1.0 -1.3
Medication: Aspirin 0.4 0.6 1.7 0.6 -1.3 0.8 -0.1 -0.2
Medication: Gliclazide 0.3 0.3 1.2 0.0 0.0 -0.1 0.5 1.1
Illnesses of father: None of the above (group 1) 0.4 0.5 1.4 -0.5 -0.8 -1.2 0.1 0.3
Smoking status: Current 0.4 0.7 1.6 1.3 -0.5 -0.1 1.1 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 8.5 -0.6 1.8 2.9 -0.7 -1.5
Whole body water mass 0.4 2.0 4.7 -0.5 0.5 -2.2 -1.2 -1.8
Leg predicted mass (right) 0.2 1.3 4.2 -0.7 -0.4 -2.0 -0.8 -1.1
Arm fat mass (left) 0.2 0.8 1.6 0.4 0.4 -1.1 0.8 -1.3
Number of self-reported non-cancer illnesses 0.3 0.6 1.1 1.0 -1.1 -0.4 0.8 0.2
Average weekly champagne plus white wine intake 2.0 2.7 6.4 -0.4 1.9 -0.7 -2.5 -1.6
Miserableness 0.8 1.3 4.4 -0.5 0.7 -0.6 -2.1 -1.1
Guilty feelings 0.5 0.7 1.5 -0.7 -1.0 0.7 -1.2 -0.1
Wears glasses or contact lenses 0.5 0.6 1.3 0.8 -0.1 0.7 1.1 -0.8
Ever taken oral contraceptive pill 0.2 0.2 0.9 -1.0 -0.1 -0.0 -0.2 -0.3
Hearing aid user 1.2 1.4 3.2 1.8 1.4 0.4 0.6 -1.2
Mother’s age at death 0.3 0.4 1.3 -0.6 0.5 -1.1 -0.2 0.5
Financial situation satisfaction 0.5 0.6 2.3 1.5 -0.9 -0.1 0.1 0.0
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.7 -0.9 -0.5 -0.3 -0.2 1.6
Commuting to job workplace: Public transport 0.3 0.4 0.8 0.6 -0.4 0.3 0.7 -0.9
Eye problems/disorders: Glaucoma 4.0 4.8 7.8 -1.8 -2.3 -2.3 -1.5 2.8
Medication: Blood pressure 0.5 1.0 3.2 -0.1 -0.9 -0.3 0.8 1.8
Pain type(s) experienced in last month: Hip pain 0.2 0.2 1.0 -0.0 0.4 -0.2 -1.0 0.0
Supplements: Fish oil (including cod liver oil) 2.4 3.1 6.2 -2.1 -1.7 -0.4 -1.4 2.5
High cholesterol (Self-reported) 0.6 1.1 3.8 1.0 0.7 0.1 -0.4 -2.0
Medication: Bendroflumethiazide 0.4 0.6 0.9 0.7 -1.0 0.8 0.9 -0.1
Medication: Paracetamol 2.3 3.5 10.8 -1.6 0.7 -3.3 -1.7 1.0
Medication: Lisinopril 0.2 0.2 0.7 0.7 -0.1 0.8 0.0 0.1
Medication: Atorvastatin 1.3 1.6 3.2 1.8 1.3 0.5 1.1 -1.4
Illnesses of father: High blood pressure 0.3 0.4 1.1 -0.4 0.4 -1.1 -0.6 -0.2
Alcohol drinker status: Never 0.5 0.5 2.6 -0.3 0.1 0.2 -1.6 0.1
Ever smoked 0.8 1.3 4.9 -0.8 0.7 -2.2 -0.1 -0.8
Basal metabolic rate 0.3 1.8 4.5 -0.4 0.5 -2.1 -1.0 -1.8
Leg fat percentage (left) 0.8 2.8 5.2 2.0 1.0 0.6 2.3 -1.8
Arm fat-free mass (left) 0.3 1.6 3.9 -0.1 0.8 -1.8 -0.5 -2.0
Number of operations (self-reported) 0.2 0.3 0.6 0.7 0.8 -0.1 0.5 -0.2
Average weekly beer plus cider intake 1.3 2.0 6.3 -1.7 0.1 -0.6 -2.5 0.5
Irritability 0.8 1.4 3.3 1.2 0.8 -1.1 -0.6 -1.8
Risk taking 0.1 0.2 0.7 0.4 0.9 -0.4 -0.2 -0.2
Ever had prostate specific antigen (PSA) test 0.2 0.2 1.0 -1.0 -0.2 0.3 -0.3 0.2
Fractured/broken bones in last 5 years 0.4 0.6 1.3 -1.1 -0.8 -0.4 -0.6 0.7
Age started oral contraceptive pill 0.4 0.5 0.9 -0.2 0.8 -0.9 0.4 0.9
Diastolic blood pressure, automated reading 0.4 1.1 2.3 -0.8 1.5 -1.0 -1.1 -0.5
Ever depressed for a whole week 1.2 1.5 3.9 2.0 -0.9 1.0 1.3 0.1
Unable to work because of sickness or disability 2.6 3.4 4.8 1.9 2.2 1.1 1.5 -2.2
Commuting to job workplace: Cycle 1.0 1.2 4.5 0.9 -2.1 0.6 0.6 0.4
Myopia 0.5 0.7 2.2 0.2 -0.4 1.5 0.9 0.4
Vascular/heart problems diagnosed by doctor 0.3 0.9 1.9 0.2 1.2 1.0 0.1 -1.4
Cholesterol lowering medication 1.1 1.6 2.7 1.6 -0.1 1.3 1.6 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.3 1.5 3.0 -1.7 -1.3 -0.9 -1.2 0.9
Pain experienced in last month 0.6 0.9 2.1 0.9 0.3 1.3 0.1 -1.5
Supplements: Calcium 0.9 1.0 3.1 -0.4 -0.9 0.6 0.8 1.8
Basal cell carcinoma (self-reported) 0.1 0.2 0.2 -0.4 0.5 -0.4 0.5 -0.0
Heart attack/myocardial infarction (self-reported) 1.6 2.0 4.8 1.5 1.3 1.1 0.2 -2.2
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 4.1 1.5 0.9 0.9 0.9 -2.0
Heart disease (siblings) 0.4 0.5 1.8 0.4 0.7 0.4 1.3 -0.2
Alcohol drinker status: Previous 0.4 0.4 1.2 -1.1 0.1 0.6 0.1 -0.8
Pack years of smoking 4.9 7.2 11.0 3.3 3.1 1.1 2.3 -3.0
Impedance of whole body 0.2 1.0 2.5 0.7 1.0 1.6 0.6 0.7
Leg fat mass (left) 0.4 1.6 3.1 1.3 0.8 -0.3 1.5 -1.8
Arm predicted mass (left) 0.3 1.4 3.7 -0.1 0.7 -1.6 -0.5 -1.9