TWAS hub - SNCG

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1060	0.0330	6.3e-07	0.042	0.054	0.088	0.059	0.080	6.1e-06	3.3e-07	6.9e-11	9.1e-08	5.8e-10
2	GTEx	Cells Transformed fibroblasts	0.0860	0.0320	6.7e-04	0.061	NA	0.051	NA	0.059	2.3e-05	NA	1.1e-04	NA	3.2e-05
3	GTEx	Lung	0.0866	0.0377	2.7e-03	0.035	NA	0.046	NA	0.044	1.1e-03	NA	1.9e-04	NA	2.5e-04
4	GTEx	Nerve Tibial	0.0684	0.0361	9.4e-03	0.021	NA	-0.001	NA	0.011	1.2e-02	NA	4.0e-01	NA	5.2e-02
5	GTEx	Skin Not Sun Exposed Suprapubic	0.1490	0.0480	1.5e-04	0.099	NA	0.118	NA	0.128	4.3e-06	NA	5.6e-07	NA	1.8e-07
6	GTEx	Skin Sun Exposed Lower leg	0.0880	0.0350	8.3e-04	0.012	NA	0.049	NA	0.048	3.2e-02	NA	6.3e-05	NA	8.1e-05
7	GTEx	Thyroid	0.0950	0.0440	6.4e-03	0.048	NA	0.046	NA	0.044	1.4e-04	NA	2.0e-04	NA	2.7e-04
8	TCGA	Brain Lower Grade Glioma	0.0786	0.0345	2.4e-04	0.021	0.029	0.024	NA	0.030	1.7e-03	2.6e-04	8.6e-04	NA	2.1e-04
9	TCGA	Lung Squamous Cell Carcinoma	0.0364	0.0215	5.2e-03	0.033	0.010	0.012	NA	0.013	9.8e-05	2.4e-02	1.4e-02	NA	1.2e-02
10	TCGA	Thyroid Carcinoma	0.0850	0.0290	2.5e-10	0.141	0.109	0.126	NA	0.132	1.4e-13	8.6e-11	2.9e-12	NA	7.9e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Heart attack/myocardial infarction (self-reported)	4.4	5.7	12.7	1.7	3.6	3.4	3.1	2.5	1.8	1.8	-1.3	1.8	-1.7
Heart attack	4.0	5.1	11.4	1.8	3.2	3.4	3.0	2.4	1.3	1.7	-1.1	1.8	-1.7
Shortness of breath walking on level ground	4.0	4.8	9.7	-2.5	-2.1	-1.6	-2.3	-2.0	-2.4	-3.1	1.6	-1.7	2.1
Had major operations	4.0	4.7	11.7	-2.5	-1.7	-1.3	-3.4	-2.5	-1.7	-2.0	1.7	-1.5	2.4
Blood clot in the leg (DVT)	3.8	4.9	15.8	1.2	2.6	1.4	1.9	2.7	4.0	1.7	-1.9	-1.0	-2.1
Comparative body size at age 10	3.4	9.5	16.6	2.8	4.1	3.0	3.1	3.2	1.9	3.8	-2.5	2.5	-3.3
Deep venous thrombosis (DVT) (self-reported)	3.3	4.3	14.2	1.3	2.7	1.3	1.9	2.4	3.8	1.2	-1.7	-0.9	-1.8
Severe depression (siblings)	3.2	3.6	6.8	-0.0	2.6	1.6	1.6	1.7	2.6	0.2	-1.8	2.6	-2.2
Health satisfaction	3.2	4.2	9.6	-1.7	-1.5	-1.5	-2.4	-1.8	-1.9	-3.1	1.3	-2.8	1.7
Osteoporosis (self-reported)	2.8	3.4	9.1	-0.9	-3.0	-1.8	-2.1	-1.6	-1.2	-1.5	1.1	-2.9	1.1
Friendships satisfaction	2.5	3.2	6.4	1.4	-2.0	1.6	0.4	-2.5	-1.2	-1.4	2.4	-1.6	2.2
Verbal and Numeric Reasoning (VNR)	2.4	5.8	12.4	2.2	2.4	3.5	3.0	2.0	1.7	1.9	-2.3	2.0	-2.4
Fluid intelligence score	2.4	5.0	10.2	2.6	2.0	3.2	2.9	1.7	1.8	1.9	-1.3	1.5	-2.3
Alzheimer’s Disease (in father)	2.3	2.5	7.6	-0.0	1.5	1.2	1.8	1.9	0.2	1.2	-1.5	2.8	-1.7
Triglycerides	2.2	3.6	7.2	-1.2	-2.4	-1.9	-2.4	-1.9	-2.7	-1.4	1.9	0.0	1.8
Allergy	2.1	4.9	11.1	1.5	-3.0	-1.5	-1.2	-3.3	-1.7	-1.2	3.3	-0.9	2.6
Breastfed as a baby	2.1	2.6	6.4	1.1	2.4	0.9	1.2	2.5	1.3	1.4	-1.8	0.6	-1.9
Commuting to job workplace: Cycle	2.1	2.5	5.4	1.8	1.8	1.4	2.2	1.2	1.5	0.5	-0.7	2.3	-1.3
Hayfever, allergic rhinitis or eczema	2.0	4.2	8.1	-0.6	2.9	1.6	1.6	2.5	1.1	1.3	-2.8	2.4	-2.4
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.6	-1.6	-1.9	-0.8	-1.1	-2.1	-2.1	-0.9	1.2	-1.4	1.4
Diabetes (mother)	1.9	2.4	5.4	0.5	1.9	0.7	1.4	2.3	1.4	1.4	-1.6	0.7	-2.3
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	6.7	-2.6	-1.6	-1.5	-1.5	-1.3	-2.4	0.8	-0.1	-0.8	0.7
Leg fat-free mass (left)	1.7	8.8	19.8	0.3	3.0	1.6	1.1	3.5	4.5	3.8	-3.6	-1.8	-3.4
High blood pressure (mother)	1.7	2.4	5.4	0.6	1.4	1.6	1.4	2.3	0.2	2.1	-1.3	0.8	-2.1
Leg predicted mass (left)	1.7	8.9	19.9	0.3	3.1	1.7	1.2	3.5	4.5	3.9	-3.6	-1.9	-3.5
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	5.9	-0.7	-0.8	-0.2	-0.9	-2.4	0.2	-2.3	1.0	-1.5	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.2	0.8	2.0	1.4	1.6	1.7	1.2	0.7	-1.3	1.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	7.9	0.7	0.9	1.4	1.4	0.3	2.8	1.3	-1.9	0.8	-1.1
Commuting to job workplace: Public transport	1.7	2.0	11.3	2.0	0.7	0.6	-0.8	0.4	1.5	-0.6	0.5	-3.4	-0.6
Major Depression (MDD)	1.6	1.9	7.5	-0.4	-0.9	-0.4	-1.0	-1.6	0.4	-2.7	1.8	-0.8	1.7
Rheumatoid Arthritis	1.6	2.1	5.4	0.5	1.7	1.4	1.3	2.2	1.4	0.8	-2.3	1.1	-0.9
Pack years adult smoking proportion	1.6	2.5	6.1	-2.5	-1.7	-1.7	-2.5	-1.4	-1.2	-0.8	0.2	-1.6	0.8
Age when periods started (menarche)	1.6	3.8	6.8	-0.8	-2.6	-2.5	-2.0	-1.9	-1.4	-1.2	1.4	-2.3	2.5
Number of children fathered	1.6	1.9	5.9	-2.4	-1.7	-0.7	-1.6	-1.7	-1.6	-0.7	0.2	-0.9	0.6
Illnesses of father: Heart disease	1.6	2.2	6.3	-2.5	-1.7	-2.0	-1.1	-1.2	-1.2	-1.1	-0.0	-1.7	1.1
Leg fat-free mass (right)	1.6	8.6	20.0	0.5	3.2	1.9	1.2	3.3	4.5	3.7	-3.5	-1.9	-3.2
Medication for cholesterol	1.6	2.4	7.0	1.8	1.2	1.1	0.9	1.1	1.8	2.6	-1.2	-0.4	-1.9
Leg predicted mass (right)	1.6	8.6	19.6	0.5	3.2	1.8	1.2	3.3	4.4	3.7	-3.6	-1.9	-3.3
Worry (Nagel 2018)	1.5	3.2	10.0	-2.1	-1.8	-1.4	-2.0	-1.2	-0.8	-1.3	1.2	-3.2	1.9
Body Mass Index (BMI) (2010)	1.5	2.1	4.7	0.6	1.5	1.9	1.6	1.1	0.8	1.7	-1.6	0.0	-2.2
Supplements: Zinc	1.5	1.6	4.2	0.9	1.3	0.9	2.1	1.1	0.3	1.4	-1.2	1.6	-1.1
Had menopause	1.5	1.9	4.7	2.1	1.8	1.5	1.0	2.2	1.0	-0.3	-0.5	-0.5	-1.4
Worrier / anxious feelings	1.5	2.8	6.6	-1.4	-1.8	-1.3	-1.7	-1.3	-1.4	-1.3	1.5	-2.6	1.9
Happiness	1.5	1.9	6.8	-0.1	-0.9	0.6	-0.7	-1.4	-0.5	-2.6	1.2	-2.0	1.6
High blood pressure (siblings)	1.5	2.2	5.6	2.3	1.5	1.6	2.4	0.7	1.1	0.8	0.2	1.9	-0.4
Eye problems/disorders: None of the above	1.5	1.8	4.9	-1.0	-0.6	-0.8	-1.8	-1.3	-1.0	-2.2	1.0	-1.6	1.1
Eye problems/disorders: Cataract	1.5	1.8	7.9	1.6	1.3	1.3	1.6	0.4	0.6	0.8	-0.2	2.8	-0.3
Angina	1.4	1.8	3.7	1.1	1.7	1.9	1.9	1.8	0.7	0.8	-0.8	0.4	-1.3
Asthma	1.4	2.8	5.8	-0.6	2.4	2.1	1.0	2.2	1.4	1.0	-2.4	-0.2	-1.8
Arm fat-free mass (right)	1.4	7.3	15.1	0.1	2.7	1.2	0.9	2.8	3.6	3.9	-3.4	-2.3	-3.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.0	-1.5	-0.7	-1.4	-1.3	-1.3	-0.9	-1.7	0.2	-0.2	2.0
Arm predicted mass (right)	1.4	7.3	15.1	0.3	2.7	1.1	0.9	2.9	3.6	3.9	-3.3	-2.4	-3.3
Qualifications: nursing, teaching	1.4	2.2	7.6	1.7	1.2	2.1	2.0	0.9	0.0	0.6	0.0	2.8	-0.4
Number of operations (self-reported)	1.4	2.1	6.9	-2.6	-2.0	-0.7	-2.2	-0.8	-0.8	0.2	0.9	-1.5	0.5
Breast Cancer	1.3	3.1	6.6	-1.0	-2.1	-1.5	-1.4	-1.9	-1.8	-2.6	1.7	-0.8	2.0
Serious illness, injury or assault to yourself	1.3	1.6	4.8	-2.2	-1.0	-1.0	-1.8	-1.1	0.4	-1.0	-0.3	-1.4	1.2
Noisy workplace	1.3	1.7	6.5	-2.5	-1.3	-1.1	-1.8	-0.1	-0.8	-0.6	-0.1	-1.7	0.4
Length of working week for main job	1.3	1.5	4.4	1.3	2.1	0.9	1.7	0.8	0.8	0.7	-0.7	1.2	-1.1
Average weekly red wine intake	1.3	1.9	4.9	-0.7	-1.4	-1.5	-1.2	-1.9	-2.2	-1.1	0.9	-0.0	1.6
Asthma (self-reported)	1.3	2.6	5.7	-0.8	2.2	2.4	0.9	2.1	1.1	0.7	-2.2	-0.2	-1.5
Financial situation satisfaction	1.3	1.6	3.5	0.2	-1.2	0.1	-0.6	-1.7	-0.8	-1.5	1.9	-1.6	1.5
Alcohol drinker status: Never	1.3	1.6	4.2	0.9	1.8	2.1	1.0	1.1	1.0	-0.2	-1.2	1.5	-0.8
Basal metabolic rate	1.3	7.3	16.3	0.1	2.8	1.3	1.0	2.9	4.0	3.6	-3.4	-2.0	-3.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.1	1.1	1.7	1.6	1.8	1.0	1.3	0.8	-1.1	1.7	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.5	1.5	2.0	1.0	0.7	0.2	2.4	0.5	-0.4	0.9	-0.7
Pulse wave reflection index	1.2	1.5	4.4	-0.8	0.7	0.8	1.1	1.4	-0.3	2.1	-2.0	0.0	-1.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	9.0	-0.1	-1.4	-0.8	-0.5	-1.3	-2.3	-3.0	1.3	-0.1	1.8
Angina (self-reported)	1.2	1.6	3.5	1.2	1.9	1.7	1.6	1.7	0.7	0.7	-0.7	0.5	-1.1
Leg pain on walking	1.2	1.6	3.7	-1.2	-0.7	-1.6	-1.9	-1.4	-0.9	-1.7	0.9	-0.1	1.0
Whole body fat-free mass	1.2	7.1	17.0	0.2	2.5	1.1	0.9	2.7	4.1	3.8	-3.2	-2.1	-3.0
Osteoarthritis (self-reported)	1.2	1.5	4.6	0.2	1.3	1.1	1.5	1.5	2.1	0.8	-1.0	0.2	-1.3
Whole body water mass	1.2	7.1	16.6	0.1	2.5	1.1	0.9	2.7	4.1	3.8	-3.3	-2.1	-3.0
Illnesses of father: High blood pressure	1.2	1.5	3.9	0.1	0.2	0.9	0.6	1.8	0.3	2.0	-1.6	1.1	-1.6
Pack years of smoking	1.2	1.8	4.4	-1.9	-1.4	-1.7	-2.1	-1.1	-1.0	-0.8	0.4	-1.1	0.9
Arm predicted mass (left)	1.2	5.9	12.9	-0.1	2.4	1.0	0.9	2.5	3.3	3.6	-3.2	-1.9	-2.9
Allergy or Eczema	1.1	2.8	5.2	-0.8	2.1	1.9	1.0	2.3	0.4	0.6	-2.2	1.9	-2.0
Impedance of leg (left)	1.1	5.2	11.7	-0.1	-2.3	-2.0	-1.3	-2.9	-2.3	-3.4	3.0	0.1	2.6
Weight	1.1	5.4	11.1	-0.1	2.6	1.2	0.9	3.3	2.8	2.2	-3.0	-1.9	-3.0
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.8	-1.4	-1.3	-1.0	-2.2	-0.9	-1.5	0.3	0.3	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.1	-1.3	-0.9	-0.9	-0.7	-1.5	-1.8	-0.1	0.8	0.8	1.3
Medication: Aspirin	1.1	1.4	7.1	-2.7	-0.4	-1.1	-1.2	-0.7	-1.4	-0.7	-0.5	0.4	0.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	8.4	-0.6	-1.1	-0.1	0.1	-0.0	-2.9	-0.8	-0.3	1.4	0.1
Arm fat-free mass (left)	1.1	5.8	12.0	-0.5	2.3	0.9	0.7	2.4	3.3	3.5	-3.2	-2.0	-2.8
Basal cell carcinoma (self-reported)	1.1	1.3	5.7	0.0	0.5	1.3	1.2	1.3	0.6	2.4	-0.9	0.6	-1.1
Neuroticism (Nagel 2018)	1.0	2.4	7.0	-1.2	-1.7	-1.4	-1.0	-1.6	-0.1	-0.4	1.8	-2.7	1.9
HDL Cholesterol	1.0	1.7	5.9	0.4	1.6	1.1	0.9	1.4	2.4	0.7	-1.2	0.0	-1.5
BMI	1.0	5.7	12.5	0.2	3.4	1.9	1.7	3.5	1.1	2.1	-3.1	-0.2	-3.4
Impedance of leg (right)	1.0	4.9	9.1	-0.4	-2.6	-2.2	-1.3	-2.7	-2.3	-3.0	3.0	0.2	2.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.9	-1.5	-1.3	-0.9	-1.0	-0.4	-2.0	-0.2	0.5	-1.0	-0.1
Trunk fat-free mass	1.0	5.5	14.4	0.3	2.1	0.8	0.9	2.0	3.8	3.5	-2.7	-2.0	-2.5
Lung cancer (father)	1.0	1.2	3.4	1.1	0.1	0.8	1.1	1.3	1.0	1.9	-0.6	-0.9	-1.2
Illnesses of mother	1.0	1.2	3.1	0.5	-0.7	-1.0	-0.1	-1.4	0.7	-1.8	1.1	-0.8	1.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.9	-1.9	0.7	0.7	-0.0	1.3	-0.1	0.3	-2.0	-1.1	-1.4
Supplements: Calcium	1.0	1.1	3.1	-0.9	0.7	0.5	0.3	1.2	0.1	0.8	-1.8	1.7	-1.0
Impedance of whole body	1.0	5.2	13.4	0.2	-2.2	-1.7	-1.3	-2.7	-1.5	-3.7	3.4	-0.0	2.8
Intelligence (Savage-Jansen 2018)	0.9	2.6	10.1	2.2	0.8	3.2	2.0	0.3	1.8	1.2	-0.5	1.0	-0.7
Lupus	0.9	1.3	3.3	0.5	1.6	1.1	0.6	1.5	0.9	1.1	-1.0	-0.1	-1.8
Hypothyroidism (self reported)	0.9	2.2	5.9	0.4	-1.6	-0.7	-0.3	-1.6	-2.1	-2.4	1.4	0.1	1.9
Neuroticism	0.9	2.1	6.9	-0.6	-0.9	-1.4	-1.0	-1.6	0.6	-0.2	1.8	-2.6	1.9
Medication for hormone replacement therapy	0.9	1.0	2.5	-1.6	-0.5	-1.1	-0.8	-0.5	0.5	-1.4	0.0	-0.6	1.5
Townsend deprivation index at recruitment	0.9	1.2	3.9	2.0	0.6	1.4	1.6	-0.4	-0.2	-0.8	1.0	1.2	0.7
Multivitamins +/- minerals	0.9	1.2	3.1	-1.8	-1.2	-0.2	-1.0	-0.8	-1.7	-1.2	-0.7	0.8	-0.1
Waist circumference	0.9	3.3	8.1	-1.0	1.8	0.4	-0.2	2.9	1.3	0.7	-2.7	-1.8	-2.6
Pulse rate	0.9	1.5	5.2	-0.2	-1.4	-0.8	-1.4	-0.9	-0.1	-0.6	1.5	-2.3	1.2
Prospective memory result	0.9	1.0	1.7	-0.4	1.3	1.0	1.0	1.1	1.1	0.9	-1.1	1.2	-0.9
Trunk predicted mass	0.9	5.4	14.5	0.4	2.1	0.8	0.9	2.0	3.8	3.5	-2.6	-2.1	-2.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.9	0.8	1.7	0.8	1.2	0.2	1.6	0.7	-1.0	1.3	-0.4
Glaucoma (self-reported)	0.9	1.1	2.2	-1.1	-1.3	-0.3	-0.2	1.3	-0.8	1.0	-1.1	-1.5	-1.1
Gout (self-reported)	0.9	1.2	7.5	-2.7	-0.9	-0.6	-1.0	-0.2	-0.5	0.4	0.3	-1.3	0.6
Medication: Omeprazole	0.9	1.1	3.1	-1.1	-0.5	-1.0	-1.2	-1.2	0.8	-0.6	-0.1	-1.8	1.2
Arm fat mass (left)	0.9	3.5	8.5	-0.5	2.3	1.0	0.6	2.9	1.5	1.3	-2.7	-1.4	-2.5
Wears glasses or contact lenses	0.9	1.0	2.6	-1.4	-0.7	-0.7	-1.5	0.2	-1.6	-1.2	-0.4	-0.6	0.1
Eye problems/disorders: Glaucoma	0.9	1.0	4.3	-0.1	-1.2	-0.1	0.2	0.8	-0.2	2.1	-0.2	-1.7	-0.8
Bipolar Disorder (2018)	0.8	1.2	5.7	2.4	0.8	1.1	1.4	0.7	1.2	-0.4	0.5	0.0	0.3
Depression (Nagel 2018)	0.8	1.3	3.3	1.4	1.3	1.0	1.8	0.8	1.8	-0.1	0.4	0.8	-0.3
Fasting Glucose	0.8	0.9	2.4	-0.6	-1.6	-1.4	-1.1	-0.5	-0.6	1.0	0.0	-1.3	0.0
Sensitivity / hurt feelings	0.8	1.3	2.7	-1.4	-1.1	-0.6	-1.5	-1.6	-0.6	-0.9	0.8	-0.8	1.6
Medication: Co-codamol	0.8	1.0	4.2	0.1	1.0	2.1	0.7	0.9	1.0	-1.2	-0.2	0.6	-0.3
Medication: Levothyroxine sodium	0.8	1.4	4.9	0.1	-0.3	-1.0	-0.5	-0.9	-1.9	-2.2	1.2	0.3	1.5
Alcohol usually taken with meals	0.8	1.4	2.7	-1.0	-1.6	-0.6	-0.6	-1.6	-1.6	0.6	0.8	-1.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	-0.4	-0.5	-0.7	-1.3	-0.9	-0.3	-1.1	1.1	-1.5	1.3
Pulse wave peak to peak time	0.8	0.9	2.0	1.3	1.3	1.3	0.7	-0.3	1.1	-0.4	0.3	1.4	-0.0
Whole body fat mass	0.8	3.4	8.2	-0.3	2.2	1.1	0.7	2.9	1.7	1.1	-2.5	-1.7	-2.4
Leg fat mass (right)	0.8	3.3	8.0	-0.6	2.0	1.0	0.6	2.8	1.5	1.1	-2.6	-1.6	-2.4
Breast cancer (self-reported)	0.8	1.0	2.9	-0.7	-1.4	0.8	0.1	-1.7	-1.4	-0.0	0.5	1.1	0.5
Unable to work because of sickness or disability	0.8	1.1	2.2	-0.3	-0.9	-0.7	-1.0	-1.1	-0.9	-1.2	1.5	-1.3	1.0
Leg fat mass (left)	0.8	3.1	7.6	-0.6	2.1	0.9	0.5	2.8	1.4	1.0	-2.5	-1.7	-2.4
Schizophrenia vs Biploar Disorder	0.7	0.9	2.5	-0.9	0.6	0.7	-0.6	0.5	1.3	0.9	-1.1	-1.6	-0.8
Ulcerative Colitis (UC)	0.7	1.2	3.6	0.3	1.0	0.8	0.6	1.9	-0.2	1.2	-1.4	0.6	-1.7
Coronary Artery Disease (CAD)	0.7	0.9	2.3	1.5	0.6	1.4	1.5	1.1	0.9	0.0	-0.2	0.0	-0.0
Crohns Disease (2012)	0.7	1.1	2.9	-0.3	-1.3	-0.1	-0.7	-0.6	-1.0	0.1	1.7	-1.5	1.3
LDL Cholesterol	0.7	1.0	2.3	-1.4	-1.3	-1.2	-1.5	-1.2	-0.5	0.2	0.8	0.0	0.8
Lung FVC	0.7	3.3	9.8	1.8	1.6	1.1	2.4	0.8	3.1	2.3	-1.7	0.9	-0.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.8	-1.0	-1.0	-0.4	-0.3	-0.6	-1.3	-1.3	0.8	-0.8	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.1	1.7	0.5	0.6	1.4	0.2	1.5	-0.3	0.7	0.8	0.2
Stomach or abdominal pain in last month	0.7	0.9	3.6	-1.1	-0.4	-0.5	-0.6	-0.5	0.3	1.4	0.5	-1.9	0.8
Body mass index (BMI)	0.7	3.1	9.2	-0.6	2.1	0.9	0.7	3.0	0.6	1.4	-2.6	-0.7	-2.6
Trunk fat mass	0.7	2.8	7.0	-0.4	1.9	0.9	0.5	2.6	1.7	0.8	-2.2	-1.9	-2.2
Medication: Simvastatin	0.7	1.0	5.9	-2.4	-0.5	-0.4	-0.6	-0.5	-1.2	-1.1	-0.0	-0.1	0.8
Hip circumference	0.7	2.9	6.8	-0.3	1.9	0.9	0.3	2.6	1.8	1.2	-2.1	-1.8	-2.3
Time employed in main current job	0.7	0.8	2.9	0.9	-0.1	0.4	1.1	0.6	-1.7	1.0	0.2	0.9	-0.5
Number of live births	0.7	1.0	2.4	-0.3	-0.5	-0.9	-1.0	-1.5	-0.8	-1.3	1.2	-0.8	1.3
Pulse wave Arterial Stiffness index	0.7	0.8	2.2	-1.2	-1.0	-1.1	-0.6	0.6	-0.6	0.7	-0.7	-1.5	-0.4
Medication: Allopurinol	0.7	0.9	5.5	-2.4	-0.3	-0.7	-1.1	-0.2	-0.2	0.3	0.5	-0.8	0.7
Medication: Seretide 50 evohaler	0.7	0.8	4.9	-2.2	0.3	0.1	-1.2	-0.3	-0.7	-0.4	-0.4	0.6	-0.1
Comparative height size at age 10	0.7	3.7	14.6	0.7	2.2	1.2	1.1	1.8	3.8	1.6	-2.0	-0.8	-2.2
Suffer from ‘nerves’	0.7	1.1	5.2	0.1	1.1	1.1	1.4	0.6	2.3	0.8	-0.7	-0.0	-0.2
Supplements: Vitamin C	0.7	0.8	3.2	1.8	0.2	1.1	1.3	0.6	-0.0	-0.9	-0.0	0.9	0.0
Medication: Aspirin	0.7	0.9	4.8	-2.2	-0.2	-0.8	-1.0	-0.7	-0.9	-0.6	-0.2	0.4	0.6
Mother’s age at death	0.7	0.9	3.5	0.5	1.2	0.8	1.0	0.7	-0.1	-0.3	-0.9	1.9	-0.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	0.4	-0.8	-0.5	0.0	-0.7	-1.1	-1.4	1.3	1.1	1.1
Ever smoked	0.7	1.2	2.3	-0.6	-1.0	-0.6	-0.7	-1.1	0.5	-1.5	1.4	-1.5	1.5
Cholesterol lowering medication	0.7	1.0	3.3	-1.8	-0.9	-0.4	-0.5	-0.8	-1.6	-1.3	0.3	-0.6	0.6
Depressed Affect (Nagel 2018)	0.6	1.2	3.8	-0.6	-0.8	-1.0	-0.3	-1.2	0.7	0.3	1.7	-1.9	1.0
Bipolar Disorder (2011)	0.6	0.6	2.5	1.6	0.5	0.9	1.1	0.0	1.0	0.0	0.0	0.0	0.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.2	1.8	0.5	-1.1	-0.0	1.2	0.8	0.2	0.4	-0.2	-0.1
Maternal smoking around birth	0.6	0.9	3.5	0.4	-0.3	-0.4	-0.2	-1.9	0.4	0.9	1.4	-0.7	1.1
Number of incorrect matches in round	0.6	1.0	2.9	1.2	-0.3	0.9	0.1	-0.9	0.8	-0.3	0.7	-1.7	1.5
Diabetes (self-reported)	0.6	0.9	2.0	0.7	1.2	-0.0	1.1	1.4	1.3	0.4	-0.9	0.6	-1.2
Impedance of arm (right)	0.6	2.7	9.3	0.2	-1.5	-0.7	-0.6	-1.9	-0.3	-3.1	2.5	0.3	2.3
Impedance of arm (left)	0.6	2.7	9.3	0.5	-1.4	-0.9	-0.7	-1.7	-0.5	-3.0	2.5	-0.1	2.1
Arm fat mass (right)	0.6	2.5	6.3	-0.4	1.9	0.9	0.5	2.5	1.4	0.9	-2.3	-1.3	-2.2
Emphysema/chronic bronchitis	0.6	0.7	2.9	-1.7	-0.1	0.7	-0.3	-0.8	-0.4	-0.5	-0.6	1.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.6	0.1	0.7	0.0	0.6	0.9	0.2	0.8	-1.2	1.6	-1.1
Overall health rating	0.6	1.3	2.7	-1.6	-0.6	-1.6	-1.4	-0.4	-0.5	-1.6	0.7	-0.9	1.0
Knee pain experienced in last month	0.6	0.9	3.6	-0.0	0.0	0.4	0.2	-1.1	-0.8	-1.9	0.7	0.4	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.1	0.1	0.2	0.6	0.2	-1.1	-0.6	-1.8	1.1	-0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.3	0.8	0.7	1.0	0.0	1.0	2.3	0.6	-0.3	-1.9	-1.0
Commuting to job workplace: Walk	0.6	0.6	3.7	0.3	-1.2	0.6	-0.7	-0.1	0.1	-0.3	0.5	-1.9	0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	2.2	1.2	-0.7	-0.1	-0.5	-0.7	0.0	-0.6	1.5	-1.3	0.7
Guilty feelings	0.6	0.9	2.5	-0.2	-1.6	-1.0	0.2	-1.1	-0.6	-0.4	0.6	-1.4	1.0
Medication: Lisinopril	0.6	0.7	2.0	1.3	-0.0	0.5	1.0	-0.3	0.3	0.6	1.2	0.5	1.4
Ever depressed for a whole week	0.6	0.8	2.5	0.1	0.3	0.0	-0.4	-1.2	0.5	-1.6	1.0	-0.3	1.6
Myopia	0.6	0.8	2.5	0.2	0.7	0.7	0.6	1.5	-0.5	0.4	-0.9	0.9	-1.6
Irritable Bowel Disease (IBD)	0.5	1.2	2.8	0.7	1.2	1.3	1.1	1.7	-0.3	1.6	-0.6	0.5	-1.2
Blood Eosinophil Count	0.5	3.6	8.7	-1.4	-1.2	-3.0	-2.4	-2.2	-1.7	-0.9	1.6	-1.8	2.0
Lung FEV1/FVC ratio	0.5	2.6	6.5	-0.4	-1.6	-2.0	-1.1	-1.9	-2.5	-0.4	1.9	-0.6	2.0
Hand grip strength (left)	0.5	1.2	5.8	0.9	1.6	-0.2	0.9	0.6	2.4	0.6	-0.8	0.2	-1.0
Systolic blood pressure, automated reading	0.5	1.5	7.1	-0.5	-1.4	-1.8	-0.8	0.7	-2.7	-1.0	0.7	-0.1	-0.3
Fed-up feelings	0.5	1.0	3.5	-0.1	-0.6	-0.1	-0.2	-1.3	0.9	0.2	1.4	-1.9	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	2.1	-0.8	-0.3	-1.4	-1.4	-0.2	0.3	-0.4	0.2	-0.6	0.2
Supplements: Glucosamine	0.5	0.7	3.3	0.3	0.1	0.6	0.1	0.0	-1.8	-1.0	0.9	1.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.4	-0.7	-0.6	-0.5	-0.5	-0.3	1.6	-0.1	-0.2	-1.3	0.4
Had other major operations	0.5	0.6	2.8	-0.6	-0.1	-0.4	0.1	0.6	1.7	1.3	-0.2	0.1	-0.7
Forced vital capacity (FVC)	0.5	2.0	12.5	1.0	1.5	0.3	0.7	-0.1	3.5	1.2	-1.1	-0.8	-0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.5	-0.1	1.2	0.4	1.1	1.2	0.6	0.5	-0.6	0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	9.4	1.1	1.2	-0.2	0.6	0.0	3.1	1.3	-0.8	-0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.6	0.1	0.1	0.7	0.2	1.1	0.8	1.9	-1.2	-0.6	-1.5
Standing height	0.5	4.7	26.5	1.0	1.2	0.4	0.3	0.9	5.2	2.0	-1.1	-3.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.9	-0.1	-0.0	-0.1	-0.5	-0.7	0.3	-0.4	1.4	-1.7	1.1
Loud music exposure frequency	0.5	0.6	2.3	0.3	0.5	-0.4	-1.0	-0.1	1.2	-0.6	0.3	-1.5	-0.2
Birth weight	0.5	1.0	3.3	0.4	1.1	1.1	0.8	0.7	1.5	0.6	-0.4	-1.8	-0.5
Forced vital capacity (FVC), Best measure	0.5	1.8	10.9	1.0	1.3	0.5	1.0	0.0	3.3	1.2	-0.6	-1.2	-0.3
Number of full brothers	0.5	0.6	1.7	-0.3	-0.5	-0.4	-0.7	-1.0	-0.6	0.4	0.9	-1.3	0.8
Migraine (self-reported)	0.5	0.6	2.3	-0.1	-1.5	-0.6	-0.6	-0.4	0.1	-0.2	1.2	-0.8	0.9
Medication: Ibuprofen	0.5	0.6	2.6	0.9	1.6	0.7	0.2	-0.0	1.4	-0.3	-0.1	0.7	-0.1
Number of full sisters	0.5	0.6	1.4	0.0	-0.8	-0.6	-0.6	-0.8	0.4	-0.8	1.2	-1.2	0.7
Illnesses of siblings: Diabetes	0.5	0.6	2.1	1.1	0.9	-0.1	0.4	0.8	-0.3	-0.1	0.8	1.4	-0.5
Smoking status: Previous	0.5	0.7	2.7	0.7	0.9	0.8	0.4	-0.0	1.3	-1.6	0.3	0.3	0.2
Long-standing illness, disability or infirmity	0.5	0.7	1.7	-0.5	-1.0	0.3	-0.2	-1.3	-0.9	-0.5	1.2	-0.0	1.2
Ever had bowel cancer screening	0.5	0.5	1.6	-0.4	-0.2	-1.1	-1.3	0.3	0.4	-1.2	0.4	-0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.6	0.6	-0.8	-0.5	-0.3	-0.8	-0.4	-1.6	1.5	-0.2	0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.4	0.3	0.3	0.7	0.5	-1.6	0.5	0.1	1.1	-0.6	1.2
Average weekly beer plus cider intake	0.5	0.7	4.8	-0.6	0.1	-2.2	-1.1	0.5	0.0	-0.2	-0.1	-0.5	0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.7	-0.3	0.4	-0.2	0.0	-0.0	1.6	0.4	-1.2	-1.0	-0.2
Heart disease (siblings)	0.5	0.6	1.8	-0.7	-0.3	-1.4	-0.6	-0.4	-0.9	-0.9	-0.2	-1.2	0.2
Alcohol drinker status: Previous	0.5	0.5	1.6	-1.0	-0.7	0.1	-0.4	-0.9	-0.2	-1.3	-0.3	-0.9	0.5
Crohns Disease (2017)	0.4	0.8	2.5	1.0	0.7	1.0	1.3	0.9	0.1	1.6	0.6	0.4	-0.2
Reaction Time	0.4	0.8	3.8	-1.0	0.1	-1.1	-1.1	-0.0	1.9	-0.2	0.5	-0.5	0.4
Age at First Birth	0.4	0.6	1.5	0.0	1.1	0.4	0.3	0.6	0.7	1.2	-0.9	0.1	-1.0
Ulcerative Colitis	0.4	0.5	1.7	0.4	0.6	1.3	0.5	1.3	-0.1	0.6	-0.4	0.2	-0.9
Blood Red Count	0.4	3.9	15.3	-3.3	-2.0	-1.5	-2.1	-0.2	-0.3	-0.3	0.8	-3.9	0.7
Blood White Count	0.4	2.9	8.0	-1.0	1.8	1.1	1.2	2.5	0.6	1.1	-2.8	0.4	-2.5
Systolic Blood Pressure	0.4	1.9	6.8	0.4	-0.8	-1.9	-0.1	-0.1	-2.6	-1.6	1.2	1.9	0.1
Respiratory disease	0.4	1.0	3.4	-1.5	0.3	0.3	-1.2	-0.0	-0.2	-1.5	-0.5	-1.8	0.3
Average weekly spirits intake	0.4	0.5	1.8	-0.0	0.5	-1.0	-0.5	1.4	0.6	-0.7	-0.9	-0.2	-0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.8	1.3	0.2	1.2	0.3	-1.0	0.2	-0.5	0.9	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	-0.8	-0.6	-0.7	-0.8	-0.5	-1.0	-1.3	-0.2	-0.2	0.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	-0.9	-0.2	-0.4	-0.6	-1.0	-0.1	-0.6	0.5	0.0	1.0
Vitamin and mineral supplements	0.4	0.6	2.9	-0.1	0.4	-0.0	-0.2	-0.3	1.1	1.0	0.6	-1.7	0.4
Medication: Metformin	0.4	0.6	1.2	-0.1	-1.0	-0.9	-0.9	-0.4	-1.1	-0.0	0.9	-0.9	0.4
Diabetes (father)	0.4	0.5	3.0	0.4	0.8	0.0	0.6	0.4	-0.6	0.3	-0.3	1.7	-0.4
Trunk fat percentage	0.4	1.5	4.8	-0.5	1.4	0.6	0.3	2.2	0.6	-0.2	-1.6	-1.3	-1.6
Average weekly fortified wine intake	0.4	0.4	2.9	-0.2	0.5	-0.4	-0.2	-0.0	0.1	-1.7	-0.8	0.7	0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.5	-0.2	0.2	0.1	-0.0	0.8	0.9	-0.3	-1.0	1.0	-1.2
Sitting height	0.4	2.6	15.1	1.3	1.2	1.0	0.3	-0.7	3.9	1.5	0.2	-1.9	0.5
Nervous feelings	0.4	0.8	2.3	0.2	-0.4	-0.4	-0.5	-0.9	0.8	-1.0	1.0	-1.5	1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.5	1.2	0.5	1.2	0.7	0.3	0.6	1.0	-0.4	0.1	-0.9
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	0.2	-0.1	0.0	-0.9	-0.9	-0.7	-1.1	0.7	0.6	0.9
Pain all over the body in last month	0.4	0.5	1.2	0.4	-0.6	-0.5	0.2	-0.5	-1.1	-0.9	1.0	0.5	0.6
Neuroticism score	0.4	0.8	3.2	-0.4	-0.4	-0.4	-0.2	-0.7	1.3	-0.0	1.0	-1.8	0.9
Alcohol intake versus 10 years previously	0.4	0.6	1.9	0.9	0.8	-0.4	0.6	1.4	1.3	-0.1	-0.2	-0.6	-0.3
Hair/balding pattern: Pattern 3	0.4	0.7	2.2	1.5	0.6	1.3	1.3	0.4	-0.1	-0.4	-0.3	0.2	-0.4
Exposure to tobacco smoke at home	0.4	0.4	1.2	0.5	-0.6	-0.8	-0.0	-1.1	-0.0	-0.4	0.8	0.4	0.9
Birth weight of first child	0.4	0.8	4.8	-2.2	-0.1	-0.0	-0.5	0.0	0.2	-1.4	-0.4	-0.9	0.2
Medication: Amlodipine	0.4	0.6	1.8	-0.1	-0.7	-0.3	-0.5	-1.3	-0.3	-0.7	1.3	0.3	1.0
Worry too long after embarrassment	0.4	0.7	2.6	1.2	0.7	0.5	0.7	-0.3	1.6	1.0	0.1	-0.8	-0.1
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	-1.4	0.5	0.1	-0.1	0.9	-0.1	0.5	-0.9	-1.3	-1.2
Age at first live birth	0.4	0.8	1.7	-0.4	0.2	1.2	0.3	1.2	0.9	1.3	-0.4	-0.8	-1.1
Neck or shoulder pain in last month	0.4	0.5	1.5	0.3	0.9	0.7	0.4	0.1	1.2	0.8	-0.0	0.9	-0.8
Family relationship satisfaction	0.4	0.5	2.8	0.5	0.1	1.7	0.9	0.0	0.1	-0.6	-0.2	0.6	0.4
Arm fat percentage (left)	0.4	1.6	5.4	-0.6	1.4	0.6	0.3	2.3	0.5	0.1	-1.7	-1.4	-1.6
Mineral and other dietary supplements	0.4	0.5	2.0	0.1	0.7	0.5	-0.1	-0.1	1.2	0.7	-0.5	-1.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.2	0.5	0.8	0.4	0.7	-0.3	1.8	1.4	-0.6	-0.5	-0.4
Miserableness	0.4	0.7	2.2	-0.3	-0.2	-0.2	0.1	-1.5	1.3	-0.6	1.0	-0.8	0.8
Ever taken oral contraceptive pill	0.4	0.4	1.0	0.6	0.8	-0.1	1.0	0.5	1.0	0.5	0.3	0.8	-0.3
Medication: Blood pressure	0.4	0.8	3.6	0.2	-0.1	0.1	0.5	-0.3	-1.5	-0.5	0.9	1.9	0.7
Medication: Paracetamol	0.4	0.6	2.0	0.2	-0.1	-0.7	0.4	-1.0	0.3	-0.5	1.3	0.1	1.4
Medication: Atorvastatin	0.4	0.6	2.0	1.4	1.1	0.6	0.2	0.7	1.0	-0.0	0.1	-0.4	-0.6
Diastolic blood pressure, automated reading	0.4	1.1	3.2	-1.8	-1.5	-1.4	-0.9	0.5	-1.6	-0.5	0.1	0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.6	0.8	-1.2	-1.3	-1.2	-1.2	0.4	-0.4	0.5	-1.9	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	-0.1	-0.7	-0.5	-0.3	-1.2	0.5	-0.3	0.5	-0.6	0.9
Ovarian Cancer	0.3	0.3	1.3	0.4	-0.8	0.2	-0.3	-1.1	0.4	-0.1	0.7	-0.3	0.7
Prostate Cancer	0.3	0.4	1.4	0.8	0.2	1.2	0.2	0.3	0.7	0.7	-0.1	-0.5	-0.5
Mean Putamen Volume	0.3	0.4	1.0	-0.7	-1.0	-0.7	-0.2	-0.6	-0.4	-0.5	0.6	-0.3	0.8
HbA1C	0.3	0.4	1.4	0.2	-0.0	0.8	0.0	0.4	-0.9	0.7	0.1	0.0	-1.2
Neuroticism (2016)	0.3	0.5	2.8	-1.1	-0.0	0.8	0.0	0.5	1.7	0.1	0.3	0.0	-0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.4	0.3	-0.5	0.1	0.9	-0.1	-0.4	-0.3	1.2	0.0	0.8
Height	0.3	5.3	24.7	-0.4	0.6	0.6	-0.2	0.6	5.0	2.6	-1.3	-4.2	-0.9
Chronotype (morning person)	0.3	0.7	2.0	-1.4	-0.6	0.4	-0.3	0.4	-1.4	-0.8	-0.7	-1.0	-0.4
Number of treatments/medications taken	0.3	0.6	1.7	-1.1	0.8	1.3	0.6	0.3	-0.3	-0.5	-0.4	1.3	-0.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	0.0	0.6	0.1	0.8	0.4	1.1	0.5	-0.7	0.3	-0.6
Relative age voice broke	0.3	0.5	2.2	-0.2	-0.3	0.0	-0.4	-1.5	0.1	-0.5	0.7	-0.4	1.0
Taking other prescription medications	0.3	0.4	1.9	-0.9	-0.1	0.0	-0.6	-0.3	-0.2	-1.4	0.5	-0.3	0.7
Medication: Atenolol	0.3	0.4	2.4	-0.1	0.9	0.2	0.1	-0.2	-0.1	-1.6	-0.1	0.9	0.4
Chronic bronchitis/emphysema (father)	0.3	0.4	1.2	0.4	0.2	1.0	0.3	-0.5	-0.2	-0.9	0.3	1.1	0.5
Qualifications: None of the above	0.3	0.6	1.9	0.2	-0.3	-0.3	-0.2	-0.8	-0.9	-1.4	0.9	-0.7	0.9
Medication: Ramipril	0.3	0.4	1.6	-0.1	0.7	1.3	0.4	0.5	-0.3	0.5	-0.5	0.4	-0.9
Arm fat percentage (right)	0.3	1.1	3.7	-0.9	1.0	0.5	0.3	1.9	0.2	-0.2	-1.5	-1.1	-1.3
Depression (self-reported)	0.3	0.4	1.7	-0.8	0.2	0.7	0.6	-0.0	-0.6	-0.1	-0.3	1.3	0.3
Medication: Lansoprazole	0.3	0.4	1.7	-1.1	-0.0	-0.1	-0.2	-0.0	-1.3	-0.2	-0.7	0.7	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	6.4	1.0	0.9	-0.1	0.7	-0.5	2.5	0.8	0.0	-0.7	0.3
Tense / ‘highly strung’	0.3	0.6	1.9	-1.1	-0.7	-0.5	-0.9	0.1	0.1	-0.8	0.2	-1.4	0.3
Hair/balding pattern: Pattern 4	0.3	0.7	3.0	-0.9	-1.7	-0.4	0.1	-0.4	-0.4	0.4	1.1	-0.7	0.8
Peak expiratory flow (PEF)	0.3	0.7	1.5	-0.6	0.0	-0.3	-0.8	0.1	1.1	1.2	-0.9	-1.2	-1.1
Body fat percentage	0.3	1.3	4.3	-0.8	1.3	0.4	0.2	2.1	0.2	-0.3	-1.6	-1.2	-1.5
Leg fat percentage (right)	0.3	1.0	2.8	-1.1	0.8	0.2	0.1	1.7	-0.5	-0.2	-1.4	-1.1	-1.2
Medication: Blood pressure	0.3	0.5	1.4	-0.9	0.9	1.2	0.2	0.3	-0.5	0.3	-0.4	0.9	-0.1
Heart disease (mother)	0.3	0.4	1.1	-0.6	-0.1	-0.6	-0.3	0.8	-1.1	0.4	-0.0	0.2	-0.9
Alcohol intake frequency.	0.3	0.6	1.5	1.0	1.0	1.2	0.6	1.2	0.2	-0.8	-0.3	-0.3	-0.4
Age at last live birth	0.3	0.4	0.8	-0.5	0.3	0.9	-0.0	0.8	0.5	0.9	-0.5	-0.7	-0.7
Hypertension (Self-reported)	0.3	0.8	4.0	-1.2	0.2	0.1	0.5	0.3	-1.5	0.1	0.1	2.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.7	1.0	0.4	0.1	0.6	0.1	0.1	0.0	-0.3	1.3	-0.4
Back pain experienced in last month	0.3	0.4	1.1	1.0	0.6	0.5	0.7	-0.6	-0.1	-0.5	0.7	0.9	0.7
Medication: Gliclazide	0.3	0.4	1.2	-0.4	0.0	-1.1	-0.4	-0.1	-0.7	-1.0	0.5	-0.2	0.7
Number of self-reported non-cancer illnesses	0.3	0.6	4.1	-2.0	0.3	-0.0	-0.3	-0.3	-0.6	-0.7	-0.6	0.3	0.0
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.4	0.9	-0.3	-0.9	0.2	0.8	0.6	0.1	-0.7	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.4	-0.8	-0.2	-0.1	-1.2	0.2	-0.2	-1.2	-0.2	-0.2	0.2
Medication: Bendroflumethiazide	0.3	0.4	2.9	0.0	0.4	0.5	0.5	-0.4	-0.2	-0.2	0.4	1.7	0.5
Leg fat percentage (left)	0.3	1.0	2.9	-1.0	1.0	0.3	0.2	1.7	-0.6	-0.4	-1.5	-1.1	-1.2
Risk taking	0.3	0.4	1.6	-1.0	0.4	-0.4	0.1	-0.6	0.8	1.3	-0.2	0.1	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.9	-1.4	0.6	0.4	-0.7	-0.5	-0.1	-0.5	-0.5	0.4	0.6
Age started oral contraceptive pill	0.3	0.3	1.3	0.0	-0.5	0.1	0.3	1.2	-0.3	0.9	-0.4	-0.7	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	1.5	1.2	0.4	1.1	0.1	0.3	1.1	-0.5	0.1	0.2	-0.2
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.3	0.0	0.7	0.5	0.8	-0.6	-0.1	-0.9	0.0	-0.9
Schizophrenia (2014)	0.2	0.4	1.3	0.4	0.4	1.0	0.0	0.3	1.1	-0.2	-0.7	0.0	-0.7
Heel T-Score	0.2	1.2	5.3	0.0	0.0	-1.2	-0.3	0.2	-2.2	0.2	0.5	2.3	-0.0
Waist Hip Ratio (WHR)	0.2	0.9	2.8	-1.7	0.3	-0.4	-0.9	0.6	-0.3	-1.1	-1.5	-0.5	-1.0
Cardiovascular Disease	0.2	0.8	4.1	-2.0	0.3	0.4	0.2	-0.2	-1.3	0.5	-0.3	1.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.8	0.3	0.9	0.2	0.3	0.3	0.8	-0.1	-0.7	-0.0	-0.7
Relative age of first facial hair	0.2	0.4	1.1	0.9	0.5	0.4	0.6	0.5	1.1	0.7	-0.0	0.0	-0.6
Current tobacco smoking	0.2	0.3	1.0	-0.4	-0.8	-0.0	-0.3	0.0	-1.0	0.7	0.7	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-1.0	0.7	-0.5	-0.2	0.2	-0.7	-0.4	-0.4	0.9	-0.1
High blood pressure	0.2	0.7	3.4	-0.8	0.5	0.6	0.9	0.7	-0.8	-0.0	-0.1	1.9	-0.4
Past tobacco smoking	0.2	0.4	1.4	0.2	-0.3	-0.3	-0.1	0.2	-1.1	1.2	-0.4	0.8	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.3	-0.6	-0.3	-0.5	-0.1	-0.8	0.3	-1.2	0.7	-0.1	0.7
Financial difficulties in last 2 years	0.2	0.3	1.4	-1.2	-0.1	0.2	-0.0	-0.8	-0.9	-0.1	0.3	-0.4	0.2
Mouth/teeth dental problems	0.2	0.3	1.1	0.1	-0.5	0.8	-0.4	0.9	-0.3	0.1	-0.1	-0.4	-1.0
Illnesses of siblings	0.2	0.3	0.8	-0.3	-0.2	0.2	-0.5	0.5	0.5	0.7	-0.9	-0.7	-0.8
Falls in the last year	0.2	0.3	0.9	-0.9	-0.8	-0.7	-0.3	-0.2	0.5	0.2	0.4	-0.0	0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	-1.1	0.6	-0.8	0.1	-0.7	-0.6	0.2	-0.6	0.6	0.6
Medication: Cholesterol lowering	0.2	0.3	1.4	-1.2	0.6	0.1	-0.5	0.0	0.8	-0.6	-0.2	-0.2	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.2	0.1	0.2	0.5	1.1	0.3	-0.0	-0.5	-0.1	0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	0.6	0.4	-0.0	-0.6	0.6	0.7	0.8	-0.3	-1.0	-0.4
Headache pain in last month	0.2	0.4	1.4	-1.2	0.8	0.5	-0.1	0.7	0.5	-0.1	-0.7	-0.4	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.9	1.4	-0.7	-0.6	0.2	-0.2	0.1	-0.2	0.5	-0.7	-0.0
Exposure to tobacco smoke outside home	0.2	0.3	1.2	1.1	0.7	0.2	0.6	0.0	0.7	-0.2	0.8	-0.2	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.0	0.3	-0.5	-0.7	-0.8	-0.1	-0.5	-0.2	0.2	-1.0	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	1.8	1.0	-0.3	0.6	0.1	0.3	-1.3	-0.2	0.3	-0.2	-0.2
Mean time to correctly identify matches	0.2	0.3	1.4	0.3	0.6	-0.5	-0.0	0.4	1.2	-0.0	0.7	0.4	-0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.8	-0.6	-0.6	-0.7	0.0	0.3	-0.8	0.6	-0.2	-0.0
Mood swings	0.2	0.4	1.5	-0.5	-0.1	-0.3	0.1	-0.3	0.7	-0.5	1.0	-1.2	0.5
Loneliness, isolation	0.2	0.3	1.0	0.2	-0.1	-0.3	0.6	0.0	1.0	0.8	0.7	-0.6	-0.1
Diabetes diagnosed by doctor	0.2	0.4	1.0	0.1	0.6	-1.0	0.2	0.7	0.9	0.2	-0.8	0.2	-0.6
Smoking status: Current	0.2	0.4	0.9	-0.4	-0.9	-0.2	-0.4	0.1	-0.9	0.7	0.7	-0.9	-0.1
High cholesterol (Self-reported)	0.2	0.4	1.7	-1.3	0.8	0.7	0.2	-0.0	0.3	0.8	-0.4	-0.5	-0.3
Irritability	0.2	0.4	1.2	-0.3	-0.2	-0.0	-0.6	0.6	0.9	1.1	0.3	-0.9	-0.5
Schizophrenia (2018)	0.1	0.2	0.7	-0.6	-0.2	0.5	-0.9	-0.1	0.4	-0.3	-0.2	0.0	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	1.1	-0.0	-0.2	-0.1	0.6	-0.3	0.4	0.2	-0.1	1.1	0.4
Blood Platelet Count	0.1	0.7	1.5	0.9	0.9	-1.0	-0.4	1.2	0.5	-0.7	-0.4	0.5	-1.0
Smoking Status	0.1	0.2	1.0	0.4	-0.1	0.5	-0.2	-0.2	-0.4	-0.3	1.0	-0.5	0.2
Hand grip strength (right)	0.1	0.2	1.0	0.1	0.5	-0.5	-0.4	-0.4	1.0	0.7	-0.2	0.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.3	-1.1	0.2	-0.3	-0.2	0.7	-0.8	-0.6	-0.4	0.3	-0.2
Father’s age at death	0.1	0.2	0.5	-0.1	0.3	0.7	0.0	0.5	0.4	-0.5	0.0	-0.4	-0.5
Medication: Paracetamol	0.1	0.2	0.9	0.2	0.5	-0.2	0.5	-0.2	1.0	-0.1	0.6	0.1	0.5
Qualifications: College or University degree	0.1	0.4	1.4	0.3	0.2	1.1	0.4	-0.3	1.2	0.6	-0.4	0.9	-0.4
Pulse rate, automated reading	0.1	0.3	0.8	-0.1	-0.1	0.7	0.2	-0.0	0.9	0.7	0.5	-0.6	0.6
Chest pain or discomfort	0.1	0.2	0.6	-0.8	0.5	0.2	-0.7	-0.0	-0.1	0.0	-0.1	-0.8	-0.3
Hearing aid user	0.1	0.2	0.4	-0.2	0.4	0.3	0.5	-0.1	-0.6	-0.1	0.6	0.3	0.5
Pain experienced in last month	0.1	0.2	0.5	0.6	0.0	-0.4	0.3	0.5	0.4	0.7	-0.6	0.2	-0.5
Hair Pigment	0.0	1.0	3.0	1.6	1.2	1.1	0.5	0.4	0.9	1.7	0.3	-0.5	-0.7
Tanning	0.0	0.4	1.5	-0.6	0.3	-0.0	0.3	0.9	1.2	0.7	0.1	-0.2	-0.6

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