Hub : Genes

SOAT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0590 0.0230 8.2e-05 0.034 0.027 0.024 0.025 0.022 4.6e-05 2.7e-04 5.8e-04 3.9e-04 8.6e-04
2 GTEx Adrenal Gland 0.1608 0.0670 6.0e-03 0.230 NA 0.233 NA 0.250 9.3e-09 NA 7.0e-09 NA 1.7e-09
3 GTEx Artery Tibial 0.0554 0.0249 3.9e-03 -0.002 NA 0.018 NA -0.001 4.9e-01 NA 1.4e-02 NA 3.7e-01
4 GTEx Cells Transformed fibroblasts 0.0880 0.0320 5.0e-04 0.038 NA 0.042 NA 0.043 7.8e-04 NA 4.3e-04 NA 3.5e-04
5 GTEx Whole Blood 0.0940 0.0360 2.0e-04 0.077 NA 0.058 NA 0.023 1.3e-07 NA 4.5e-06 NA 3.0e-03
6 NTR Blood 0.0136 0.0058 1.1e-03 0.018 0.009 0.010 0.009 0.012 1.3e-06 3.8e-04 2.3e-04 3.7e-04 7.0e-05
7 YFS Blood 0.1474 0.0296 0.0e+00 0.122 0.145 0.165 0.156 0.167 6.7e-38 4.4e-45 1.1e-51 9.8e-49 2.6e-52
8 TCGA Breast Invasive Carcinoma 0.0296 0.0136 6.9e-05 0.018 0.025 0.022 NA 0.022 9.4e-05 4.6e-06 1.6e-05 NA 2.0e-05
9 TCGA Skin Cutaneous Melanoma 0.2320 0.1070 9.1e-03 0.059 0.063 0.035 NA 0.042 1.1e-02 9.2e-03 4.0e-02 NA 2.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 3.1 4.9 11.8 -0.5 1.8 -2.2 -1.1 3.4 1.6 2.8 -2.3 -2.7
Bipolar Disorder or Schizophrenia 1.9 4.7 12.8 0.2 1.2 -1.8 -1.1 3.6 1.1 2.9 -2.1 -3.1
Depressed Affect (Nagel 2018) 0.8 1.6 4.7 1.9 2.2 -1.2 0.7 0.0 0.0 0.3 -0.6 -2.1
Depression (Nagel 2018) 0.3 0.4 1.7 0.7 1.3 0.2 0.2 0.0 0.6 0.0 -0.8 -0.7
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.8 -1.0 -1.7 0.6 -1.5 -0.3 0.7 0.1 -0.4 0.3
Neuroticism (Nagel 2018) 0.3 0.8 2.7 1.6 1.4 0.2 0.8 -0.6 -0.4 0.0 0.1 -1.0
Schizophrenia (2018) 0.6 1.2 3.6 0.6 0.1 -0.6 -0.5 1.9 0.1 1.4 -0.8 -1.8
Schizophrenia vs Biploar Disorder 2.0 2.7 8.3 2.9 0.9 -0.2 1.4 -2.1 -1.7 -1.8 1.3 -0.9
Worry (Nagel 2018) 0.5 1.0 2.3 0.3 -0.5 1.5 1.2 -1.2 -1.2 -0.7 1.3 0.6
Alzheimer’s Disease (in mother) 0.5 0.6 2.8 -0.2 0.3 0.4 -0.3 0.7 0.8 1.7 -0.9 -0.5
Alzheimer’s Disease (in father) 2.8 3.0 8.9 2.0 -0.1 -1.1 0.6 -1.1 -2.4 -3.0 1.9 -1.5
Alzheimer’s Disease (including proxy) 0.6 0.9 4.5 1.2 0.7 -0.9 0.3 0.6 -0.5 -0.2 0.1 -2.1
Crohns Disease (2017) 0.4 0.8 3.6 0.6 0.7 -0.1 -1.3 0.4 0.5 0.3 -0.8 -1.9
Irritable Bowel Disease (IBD) 0.4 0.9 5.1 1.0 0.9 -0.2 -1.1 0.2 -0.5 -0.3 -0.2 -2.2
Ulcerative Colitis (UC) 0.4 0.8 2.3 1.0 0.2 -0.2 -0.5 -0.4 -1.5 -1.2 0.9 -1.3
Major Depression (MDD) 1.2 1.5 3.3 1.7 0.1 -1.8 0.4 -1.7 -1.5 -1.2 0.8 -0.6
Reaction Time 0.2 0.4 1.1 -0.4 0.5 -1.1 -0.1 0.9 0.4 0.2 -0.5 -0.6
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.9 -0.6 -1.0 -0.4 -1.4 -0.1 0.8 -0.3 -0.6 -0.2
Breast Cancer 0.2 0.5 1.4 -0.5 -1.2 0.8 -0.7 -0.0 -0.5 -0.8 0.6 0.0
Ovarian Cancer 1.3 1.7 3.6 1.3 1.9 -1.9 0.8 -0.9 -1.4 -0.2 0.3 -1.6
Prostate Cancer 0.3 0.4 1.6 -0.7 -0.4 -0.3 0.3 0.1 -0.7 -1.3 0.8 -0.3
Age at First Birth 0.6 0.8 4.1 1.5 -0.0 -0.5 -0.3 -2.0 -0.6 0.0 0.2 0.5
Bipolar Disorder (2011) 2.0 1.9 7.1 -0.9 0.5 -0.2 -2.7 1.3 1.2 -0.1 -2.0 -1.4
Body Mass Index (BMI) (2010) 0.6 0.8 2.2 0.9 1.5 -1.1 1.5 -0.3 0.8 -0.3 -0.3 -0.1
Coronary Artery Disease (CAD) 1.0 1.2 2.3 -1.2 0.1 -0.2 -1.5 1.5 1.3 1.3 -1.3 -0.4
Crohns Disease (2012) 0.7 1.2 2.3 0.1 0.5 -0.6 -1.0 1.2 1.5 1.4 -1.4 -1.1
Mean Putamen Volume 1.9 2.2 5.4 -0.2 -2.3 0.9 0.3 -2.0 -1.0 -0.2 1.8 2.2
Fasting Glucose 1.3 1.5 7.4 0.6 1.0 -2.7 0.8 0.9 0.3 0.8 -1.3 -0.9
HbA1C 3.1 3.4 9.8 0.1 2.8 -3.1 -1.3 1.5 0.7 0.3 -1.9 -2.3
HDL Cholesterol 0.9 1.5 4.0 -0.2 -1.8 2.0 -0.1 -0.2 -1.6 -1.2 1.6 -0.0
LDL Cholesterol 2.3 3.6 8.0 0.9 -2.3 0.6 0.5 -2.8 -2.6 -1.2 2.0 2.3
Lupus 0.7 1.1 3.9 -1.1 0.3 -0.0 -1.9 -0.4 0.3 -2.0 -0.9 -0.2
Neuroticism (2016) 0.9 1.3 4.1 -0.0 2.0 -0.8 0.6 1.1 0.8 1.4 -1.1 -1.3
Primary Biliary Cirrhosis 0.6 0.9 3.3 0.8 -1.8 0.6 0.3 -0.6 -0.7 -0.9 1.3 0.1
Rheumatoid Arthritis 0.3 0.4 1.8 0.2 -0.0 -1.1 -0.3 0.4 -0.3 0.2 0.3 -1.3
Schizophrenia (2014) 1.1 2.5 9.4 1.5 1.3 -1.7 -0.2 1.8 0.1 1.3 -1.1 -3.1
Triglycerides 1.6 2.6 9.4 -0.3 -1.5 1.6 0.5 -2.1 -0.4 -1.5 1.3 3.1
Type 2 Diabetes (T2D) (2012) 0.9 1.1 5.4 -2.3 -0.3 -0.1 -1.3 1.0 0.1 -1.0 -0.5 0.4
Ulcerative Colitis 1.1 1.6 8.2 1.1 1.0 -0.3 -1.6 0.3 -0.6 -0.7 -0.3 -2.9
Blood Eosinophil Count 0.1 1.1 2.3 1.1 -0.8 0.6 -1.0 -1.5 -1.4 -1.4 0.9 0.1
Blood Platelet Count 0.2 2.0 5.8 -0.7 2.4 -1.3 -0.9 0.3 1.4 1.1 -2.3 -1.0
Blood Red Count 0.1 1.2 5.3 1.4 -2.3 1.3 -0.2 -0.4 -0.1 -0.0 1.0 0.7
Blood White Count 0.3 2.0 7.3 1.4 0.8 1.6 0.3 -2.7 0.3 -2.1 -0.2 1.0
Heel T-Score 0.1 0.6 2.5 -1.1 -1.6 0.4 -0.2 0.5 0.4 0.3 0.7 0.3
BMI 0.4 2.2 6.2 0.8 2.5 -0.6 -1.4 -0.3 1.3 -1.2 -2.1 -1.7
Height 0.3 5.5 16.0 -3.1 -2.3 4.0 0.2 0.7 1.4 -0.3 0.3 4.0
Waist Hip Ratio (WHR) 0.2 1.0 3.2 0.5 -0.7 -0.6 0.9 -0.1 -1.8 -0.1 1.7 -0.7
Systolic Blood Pressure 0.4 1.8 5.1 -0.9 -1.5 1.4 1.8 -0.0 -1.2 -0.9 2.3 0.8
Smoking Status 1.5 3.6 8.5 0.5 0.7 -0.8 2.9 -1.6 -2.7 -2.5 2.5 0.0
Allergy or Eczema 0.5 1.3 5.5 0.6 -1.6 1.4 -2.3 -0.4 0.6 -1.0 -0.3 -0.2
Cardiovascular Disease 0.3 1.0 4.5 -2.1 -0.9 0.0 0.2 1.7 -0.7 -0.3 0.6 0.2
Hypothyroidism (self reported) 0.3 0.6 1.3 1.0 0.8 -1.0 -0.2 -0.8 -0.6 -1.1 0.2 -0.4
Respiratory disease 0.8 1.7 5.0 1.4 0.8 -1.4 -0.1 -0.1 -2.2 -1.3 0.9 -1.8
Type 2 Diabetes (T2D) (2018) 1.0 1.9 8.1 -2.4 -0.2 -0.4 -0.9 0.2 -1.3 -2.8 0.2 0.8
Lung FEV1/FVC ratio 0.5 2.6 9.4 3.1 1.1 -0.7 1.4 -3.0 0.7 -0.5 -0.1 0.9
Lung FVC 1.3 6.4 24.3 3.2 3.7 -4.9 1.3 -0.8 0.6 0.7 -1.2 -2.1
Neuroticism 0.4 0.9 2.8 1.7 1.4 0.0 0.7 -0.8 -0.9 -0.5 0.2 -1.2
Chronotype (morning person) 0.8 1.9 3.0 -1.6 -1.6 0.0 -1.5 1.5 -1.7 -1.2 0.5 -1.7
Hair Pigment 0.0 0.3 1.6 -0.6 0.2 -0.0 -0.0 1.2 0.3 -0.4 0.3 -0.5
Tanning 0.3 3.4 10.0 1.6 -0.5 -0.4 2.1 -1.2 -3.2 -1.9 2.9 0.1
Hand grip strength (left) 0.4 0.9 2.5 -0.9 0.1 -1.6 -0.5 1.6 1.2 -0.3 -0.6 -0.8
Number of treatments/medications taken 0.9 1.6 2.9 0.3 -0.8 1.0 1.6 -1.5 -1.2 -0.3 1.7 1.7
Average weekly spirits intake 0.6 0.7 1.4 -0.9 0.4 -0.3 -1.1 0.7 0.9 -1.2 -1.0 -0.4
Sensitivity / hurt feelings 1.1 1.9 4.4 0.6 1.3 -0.8 -1.2 1.3 1.6 1.4 -2.1 -1.6
Frequency of depressed mood in last 2 weeks 1.1 1.6 4.4 -0.4 1.2 -0.3 -1.2 2.1 1.2 0.9 -1.5 -1.6
Hearing difficulty/problems: Yes 0.5 0.8 2.2 0.9 0.2 -0.5 -0.9 0.8 0.8 0.8 -0.8 -1.5
Relative age of first facial hair 0.5 0.9 2.2 -1.4 -0.9 0.9 1.1 0.7 0.1 0.7 0.7 1.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 -0.9 1.0 -0.5 0.2 0.6 0.1 -0.9 -0.4 0.2
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.2 -0.7 0.7 0.1 1.5 -0.4 0.3 1.0 -0.0 0.8
Ever had hysterectomy (womb removed) 0.5 0.6 1.2 -1.0 -1.1 0.6 -0.5 0.6 0.3 1.0 -0.4 0.9
Systolic blood pressure, automated reading 0.6 1.8 4.0 -0.9 -1.8 1.9 1.3 -0.5 -1.4 -0.6 2.0 0.9
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 4.0 -0.9 -1.5 1.8 1.6 -0.6 -1.1 -0.7 1.9 2.0
Angina 0.3 0.4 1.1 -0.3 -0.7 -0.1 1.0 0.9 -0.1 0.8 0.7 0.3
Medication for hormone replacement therapy 1.4 1.6 3.0 0.1 1.7 -1.5 1.0 1.1 0.8 1.6 -0.9 -1.5
Vitamin and mineral supplements 1.4 1.9 5.0 1.6 1.1 -0.9 -1.6 0.7 1.2 0.9 -1.6 -2.2
Supplements: Zinc 1.8 2.0 6.9 -2.6 -2.0 1.4 -0.1 1.1 -0.1 0.3 0.7 1.8
Medication: Co-codamol 0.7 0.9 3.3 1.4 1.8 -1.0 0.7 -0.5 0.0 -0.5 -0.4 -0.5
Medication: Metformin 0.4 0.6 2.4 -1.6 0.3 -0.1 -0.3 -0.5 0.3 -1.2 -0.3 0.9
Diabetes (father) 0.4 0.5 1.6 1.2 0.6 0.0 0.1 -1.2 0.3 -1.1 0.2 -0.1
Diabetes (mother) 0.5 0.6 2.1 0.0 0.3 -1.5 -0.7 1.0 -0.2 0.1 -0.4 -1.2
Severe depression (siblings) 0.8 0.9 2.4 -0.4 1.0 -0.8 -0.8 1.4 -0.1 0.8 -0.8 -1.5
Pack years adult smoking proportion 1.2 1.9 5.3 -0.9 0.8 -0.5 -2.3 1.8 0.3 1.1 -1.6 -1.7
Impedance of leg (right) 1.2 6.0 13.9 -1.9 -3.7 3.5 0.4 -0.9 -1.3 -1.6 2.3 3.7
Leg fat-free mass (left) 0.3 1.4 5.3 0.2 2.3 -0.5 -1.1 0.3 1.2 0.0 -1.7 -1.3
Trunk fat percentage 0.7 2.7 9.5 -1.2 -1.2 3.1 0.1 -1.4 -0.5 -1.7 1.1 2.3
Hand grip strength (right) 0.3 0.9 2.9 -1.4 -0.5 -1.7 -0.6 1.4 0.4 -0.6 0.1 -0.5
Townsend deprivation index at recruitment 0.9 1.2 3.4 -1.9 0.6 0.4 -1.4 1.6 0.6 -0.6 -1.2 -0.6
Current tobacco smoking 0.4 0.7 2.0 -0.5 1.2 -1.0 1.1 -0.1 0.5 1.4 -0.4 0.2
Average weekly fortified wine intake 0.8 0.9 2.9 -1.2 -1.4 0.5 -1.7 1.0 0.1 -0.7 -0.2 0.5
Maternal smoking around birth 2.9 4.2 15.4 2.0 2.5 -3.0 -1.0 0.2 -0.6 0.0 -1.3 -3.9
Fed-up feelings 0.6 1.2 4.2 0.5 2.0 -1.2 0.4 0.6 0.0 -0.4 -0.6 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.7 -0.4 1.3 0.7 -0.3 0.4 0.8 0.3 -1.3 -0.0
Relative age voice broke 0.9 1.3 4.7 -1.4 -2.2 0.4 0.3 0.8 0.6 1.3 0.7 1.3
Taking other prescription medications 0.3 0.5 1.9 0.3 -0.4 0.3 0.2 -1.3 -0.7 0.0 0.5 1.4
Age when periods started (menarche) 0.4 1.1 5.1 -0.2 -2.3 1.1 0.5 0.1 0.0 0.6 1.2 1.0
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 3.3 -1.5 -0.4 0.1 -0.2 0.8 1.1 1.8 -0.6 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.7 -0.3 -1.6 1.3 0.0 -0.9 -1.6 -1.3 1.4 0.6
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 -0.1 -0.1 0.2 -0.3 0.9 0.4 1.0 -0.5 -0.5
Qualifications: CSEs or equivalent 1.0 1.3 2.4 1.3 1.1 -1.0 1.3 -1.3 -1.1 -1.5 1.0 0.6
Serious illness, injury or assault to yourself 0.8 1.0 3.4 -1.2 0.6 0.5 -0.5 0.1 1.2 -0.3 -1.4 1.9
High blood pressure 0.5 1.5 3.5 -1.9 -1.1 0.6 1.2 1.8 -1.1 0.6 1.4 0.1
Hayfever, allergic rhinitis or eczema 0.9 2.0 7.6 -0.7 -1.8 1.7 -2.8 0.6 1.1 -1.3 -0.6 -0.0
Multivitamins +/- minerals 0.6 0.8 1.5 -1.2 -0.4 0.6 1.2 0.3 -0.9 -0.2 1.2 1.0
Stomach or abdominal pain in last month 0.8 1.0 5.0 -0.4 -0.0 0.6 -0.3 1.1 1.0 2.2 -1.0 0.2
Supplements: Glucosamine 0.1 0.1 0.6 -0.4 -0.1 0.0 0.8 -0.3 0.0 0.2 0.3 0.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 1.3 0.8 -0.7 0.4 -1.0 0.1 0.8 -0.4 -0.4
Medication: Atenolol 1.6 2.0 4.9 2.2 0.8 0.6 2.2 -1.8 -1.2 -1.1 1.3 -0.3
Medication: Levothyroxine sodium 0.5 0.8 3.0 0.8 1.7 -1.5 0.9 0.3 0.1 0.2 -0.3 -0.5
Sitting height 0.3 1.9 6.2 -0.5 2.0 0.4 0.7 1.0 2.5 1.1 -1.6 0.9
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.2 0.4 0.4 0.4 -0.4 0.1 0.3 -0.1 -0.4
High blood pressure (mother) 0.8 1.1 3.0 0.6 -0.8 0.1 1.6 0.4 -1.7 -0.4 1.7 0.1
Body mass index (BMI) 0.3 1.1 4.3 0.5 2.1 -0.4 -0.7 -0.7 0.3 -1.1 -1.1 -1.3
Impedance of leg (left) 1.2 5.8 14.1 -2.2 -3.8 2.8 0.9 -0.5 -1.7 -1.6 2.6 3.5
Leg predicted mass (left) 0.3 1.4 5.5 0.2 2.3 -0.5 -1.1 0.3 1.2 -0.0 -1.7 -1.3
Trunk fat mass 0.4 1.6 5.8 -0.9 -0.3 2.4 -0.1 -1.3 -0.2 -1.7 0.6 1.6
Waist circumference 0.2 0.8 2.5 0.1 1.3 -0.4 -0.1 -0.4 -0.7 -1.6 0.1 -1.4
Number of incorrect matches in round 1.8 3.0 6.9 -2.1 1.4 0.3 -0.7 2.6 2.2 1.6 -2.4 0.1
Past tobacco smoking 2.2 4.0 9.9 -0.9 -0.3 0.8 -3.1 0.8 2.9 2.7 -2.8 1.1
Alcohol usually taken with meals 0.7 1.1 4.8 1.0 -2.2 0.4 -0.4 -1.4 0.0 0.3 1.0 1.0
Nervous feelings 0.3 0.6 1.7 -0.2 1.3 -0.0 0.0 1.0 0.5 0.6 -0.9 -1.2
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 6.1 -1.8 0.5 0.7 -1.3 2.5 1.8 2.0 -2.1 -0.4
Hearing difficulty/problems with background noise 0.9 1.4 4.2 0.0 -0.2 -1.2 0.3 2.0 -1.1 1.2 0.3 -2.0
Hair/balding pattern: Pattern 2 0.7 0.9 2.9 -0.2 1.7 -0.7 -0.5 0.9 0.2 0.7 -0.9 -1.4
Had menopause 0.2 0.3 0.7 0.7 0.8 -0.5 0.4 -0.6 0.1 0.0 -0.6 -0.4
Had other major operations 1.7 2.1 7.8 -0.9 -2.0 1.6 1.1 -0.6 -0.3 -0.0 1.3 2.8
Forced vital capacity (FVC) 0.6 2.2 11.4 0.4 2.4 -3.4 0.4 0.5 0.7 0.1 -1.2 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.0 -1.4 -1.2 1.1 -0.8 -0.3 -0.8 -0.7 0.4 0.5
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.9 -0.3 1.2 -0.3 -1.1 0.4 1.5 -0.4 -1.7 -0.6
Qualifications: None of the above 0.7 1.4 7.5 0.8 1.7 -0.4 0.2 0.8 -1.1 0.1 -0.4 -2.7
Financial difficulties in last 2 years 0.8 1.1 3.5 -1.2 0.4 -1.0 -1.9 1.1 0.5 -0.0 -1.0 -1.2
Mouth/teeth dental problems 1.2 1.8 7.6 0.8 0.6 -0.1 0.8 -1.5 -1.8 -2.8 1.1 -0.4
Heart attack 1.2 1.5 5.3 1.0 0.6 0.7 2.3 -1.7 -0.3 -0.0 0.9 1.6
Allergy 0.9 2.1 7.6 0.1 1.0 -1.3 2.7 0.0 0.6 2.8 -0.1 1.1
Pain all over the body in last month 1.0 1.1 3.2 -0.1 1.5 -0.1 -0.1 0.6 1.5 1.3 -1.8 -0.1
Diabetes (self-reported) 1.2 1.8 4.6 -0.9 -0.1 -0.1 1.4 -1.2 -1.3 -2.1 1.3 2.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.6 0.3 -0.7 0.3 -1.3 0.1 0.5 -0.1 -0.3 -0.3
Medication: Ramipril 0.2 0.3 1.0 -1.0 0.1 0.1 -0.2 1.0 0.1 -0.2 -0.0 -0.7
Medication: Simvastatin 1.0 1.5 3.5 -1.0 -1.9 0.7 0.5 0.5 -1.6 -1.2 1.8 -0.3
Fluid intelligence score 0.6 1.2 3.5 -0.8 0.0 -1.2 -1.9 0.1 1.5 0.0 -1.5 -1.0
Illnesses of siblings 0.9 1.3 3.3 -1.1 -1.0 1.3 -1.8 1.1 1.1 0.8 -0.9 0.5
Neuroticism score 0.1 0.3 0.6 0.1 0.6 0.7 0.6 0.4 -0.8 -0.0 0.3 -0.8
Weight 0.1 0.6 1.7 -0.5 1.2 0.7 -0.7 -0.6 0.5 -1.3 -0.6 -0.0
Impedance of arm (right) 1.6 7.5 17.6 -2.0 -4.2 3.8 1.3 -0.6 -1.4 -1.4 3.1 4.0
Arm fat percentage (right) 0.2 0.7 3.4 -0.5 0.4 1.4 0.1 -0.8 -0.4 -1.8 0.4 0.2
Trunk fat-free mass 0.4 2.2 8.0 0.6 2.8 -1.5 -0.7 0.4 1.2 -0.2 -1.8 -1.9
Hip circumference 0.2 0.9 3.1 -0.4 1.3 0.2 -0.9 0.1 -0.0 -1.8 -0.6 -1.3
Time employed in main current job 1.6 1.8 5.5 -1.5 -1.0 0.8 -1.1 2.0 1.1 2.3 -1.0 0.1
Alcohol intake versus 10 years previously 0.3 0.4 2.4 0.7 0.2 0.1 1.6 -0.3 -0.5 0.3 0.5 0.5
Father’s age at death 0.7 1.0 3.9 -0.5 2.0 -1.3 0.4 0.7 -0.4 0.2 -0.6 -1.3
Worrier / anxious feelings 0.4 0.8 2.4 -0.2 1.0 0.3 0.0 0.8 1.5 0.6 -1.4 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.4 -0.2 0.9 -0.7 -0.9 1.9 0.6 1.2 -1.1 -1.7
Falls in the last year 0.4 0.6 1.5 -1.2 -0.2 -0.3 -0.9 0.7 1.0 0.4 -0.8 0.6
Hair/balding pattern: Pattern 3 0.2 0.3 0.9 0.9 0.6 -0.4 1.0 -0.6 -0.2 -0.3 0.2 0.4
Number of live births 0.5 0.8 2.7 0.7 -0.2 1.6 1.3 0.2 -0.3 1.2 0.5 0.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 7.0 0.6 2.3 -2.7 0.5 -0.0 1.2 -0.3 -1.2 0.0
Pulse rate 1.0 1.8 3.6 -0.2 -0.8 0.4 1.0 -1.7 -1.8 -0.8 1.9 1.9
Happiness 0.5 0.6 1.8 1.0 1.4 0.1 -0.0 -0.6 1.0 -0.2 -1.1 -0.0
Noisy workplace 2.3 2.9 6.6 2.0 2.0 -1.6 1.3 -0.8 -2.6 -1.4 1.1 -1.9
Qualifications: A levels/AS levels or equivalent 0.2 0.5 2.1 0.7 -0.6 0.3 0.3 -0.1 1.4 0.9 0.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 6.1 -1.4 0.9 -1.3 -2.5 1.0 0.6 -0.6 -1.7 -1.3
Mouth/teeth dental problems: Dentures 0.3 0.5 1.9 0.2 0.7 0.1 0.8 0.6 0.5 1.4 -0.4 -0.6
Asthma 0.8 1.5 5.3 1.1 0.4 -1.1 -0.1 0.3 -2.3 -1.0 1.2 -1.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 3.7 0.3 1.9 0.3 0.0 0.2 0.8 0.4 -1.3 -0.5
Medication: Cholesterol lowering 1.5 2.3 4.7 -2.2 -1.9 1.4 0.9 -0.1 -1.2 -1.2 1.6 2.0
Depression (self-reported) 0.7 0.8 3.5 0.1 0.3 0.6 1.3 -0.9 -0.1 1.0 0.3 1.9
Medication: Lansoprazole 0.4 0.5 2.3 -0.3 0.0 -0.0 0.7 0.8 0.9 1.5 -0.5 0.1
Prospective memory result 1.4 1.7 5.7 2.0 0.8 1.2 2.4 -1.0 -1.1 0.1 1.1 0.3
Lung cancer (father) 1.4 1.6 4.7 2.2 1.4 -1.9 0.7 -1.1 -1.0 -0.5 0.2 -1.1
Illnesses of mother 1.8 2.2 6.0 -0.6 1.1 -1.0 -2.4 0.4 2.2 0.5 -2.4 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 8.3 0.6 2.8 -2.9 0.3 -0.1 2.2 0.4 -2.0 0.2
Pulse wave Arterial Stiffness index 0.1 0.1 0.3 -0.1 0.2 -0.3 0.1 0.3 -0.1 0.5 -0.1 -0.5
Impedance of arm (left) 2.5 11.6 30.9 -2.8 -5.6 4.9 1.0 -0.7 -1.2 -0.8 3.4 5.2
Arm fat mass (right) 0.1 0.6 2.3 -0.2 1.0 0.9 -0.3 -0.7 -0.1 -1.5 -0.2 -0.3
Trunk predicted mass 0.4 2.3 8.2 0.6 2.9 -1.6 -0.8 0.5 1.2 -0.1 -1.8 -2.0
Standing height 0.2 2.4 8.0 -1.9 -1.8 2.4 0.1 0.2 0.7 -0.3 0.8 2.8
Length of working week for main job 2.1 2.3 8.7 0.9 2.3 -3.0 1.3 0.6 0.8 1.3 -0.7 -1.1
Exposure to tobacco smoke at home 1.0 1.1 3.2 -0.8 0.1 -0.1 -1.1 0.8 -1.2 -1.8 0.2 -1.5
Breastfed as a baby 1.2 1.5 4.4 -0.5 0.5 0.6 -0.1 0.9 2.1 2.1 -1.7 0.0
Tense / ‘highly strung’ 1.0 1.6 5.6 -1.3 -1.5 1.7 0.8 0.1 0.1 1.0 0.3 2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 -0.2 0.9 -0.1 -0.1 0.4 0.1 -0.6 -0.8 -0.3
Hair/balding pattern: Pattern 4 0.3 0.7 1.7 -0.9 -0.6 -0.5 -1.1 -0.5 1.3 0.6 -1.0 0.8
Birth weight of first child 1.0 1.9 6.4 -1.1 -2.5 1.4 0.8 -0.3 -0.0 -0.1 1.6 2.0
Peak expiratory flow (PEF) 0.8 1.8 6.5 1.0 1.9 -2.5 1.5 0.6 -0.3 -1.0 -0.1 -0.9
Pulse wave reflection index 2.1 2.6 6.6 1.7 1.9 -2.6 -0.4 0.7 0.6 0.9 -1.3 -2.6
Ever highly irritable/argumentative for 2 days 2.0 2.4 7.7 1.4 2.8 -1.5 1.6 0.6 1.3 1.7 -1.4 -0.9
Loud music exposure frequency 0.9 0.9 4.3 0.5 1.4 -2.1 0.2 0.4 0.4 -0.0 -0.8 -1.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.5 0.9 -0.9 -1.2 0.5 -0.5 -0.0 0.7 0.8 0.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.8 -0.6 -1.2 -0.3 -0.9 0.2 0.6 -0.1 -0.1 1.4
Blood clot in the leg (DVT) 0.8 1.1 2.7 -1.3 0.0 1.6 -1.0 -0.2 0.9 -1.4 -0.7 1.0
Medication: Paracetamol 0.3 0.5 1.8 0.2 0.8 -0.2 -1.0 0.5 0.3 -0.0 -1.0 -1.4
Headache pain in last month 1.3 2.3 7.2 0.8 1.5 -2.6 -0.1 1.4 -0.1 0.9 -0.8 -2.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 3.1 1.3 1.8 -1.1 -0.6 -0.4 0.4 0.2 -1.1 -1.4
Glaucoma (self-reported) 1.1 1.3 3.2 -1.6 0.6 0.4 -1.1 0.8 1.8 0.8 -1.6 0.1
Gout (self-reported) 1.3 1.8 3.8 -1.0 -1.3 1.9 -1.6 -1.3 0.2 -1.5 0.1 1.8
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.7 0.8 1.6 -1.4 0.5 0.5 -0.1 0.4 -0.2 -1.0
Medication: Amlodipine 0.4 0.5 1.3 0.7 0.5 -1.1 0.9 0.8 -0.2 -0.1 0.3 -1.1
Medication: Ventolin 100micrograms inhaler 1.7 2.2 5.3 2.3 0.4 -1.2 1.3 -1.9 -1.9 -1.1 1.6 -0.1
Birth weight 0.3 0.6 2.2 -0.2 0.2 1.4 1.5 0.5 0.3 0.8 0.6 0.0
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.8 0.2 -0.9 0.6 0.4 -0.9 -1.3 -0.1 1.3 0.8
High blood pressure (siblings) 2.8 4.1 10.2 2.6 0.9 -1.7 3.2 -1.2 -2.4 -1.0 2.4 -1.6
Forced vital capacity (FVC), Best measure 1.1 3.9 10.7 -0.1 3.1 -3.3 -0.3 1.0 2.3 1.2 -2.6 -0.6
Body fat percentage 0.4 1.8 5.7 -1.0 -0.6 2.4 -0.0 -1.3 -0.6 -1.9 0.8 1.6
Leg fat percentage (right) 0.3 1.1 4.5 -0.5 0.2 1.6 -0.6 -1.3 -0.5 -2.1 0.1 0.5
Arm fat-free mass (right) 0.4 2.1 8.1 0.4 2.9 -1.3 -0.8 0.2 1.3 0.3 -2.1 -1.4
Exposure to tobacco smoke outside home 0.5 0.7 2.9 -0.7 -0.0 -0.8 -1.0 -0.3 -1.0 -1.7 0.1 -0.7
Comparative body size at age 10 0.6 1.7 5.3 1.0 -0.6 1.0 -0.1 -2.3 -1.2 -2.2 1.1 0.3
Number of full brothers 0.5 0.7 2.5 0.3 1.2 -1.6 0.1 0.4 -1.0 -0.1 -0.0 -0.9
Worry too long after embarrassment 0.4 0.7 1.3 0.5 1.1 -0.2 0.9 1.1 0.5 1.0 -0.7 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.9 -0.2 1.0 -0.6 -0.2 0.8 0.6 0.8 -0.9 -0.6
Wheeze or whistling in the chest in last year 0.4 0.7 2.7 0.4 -0.1 -0.1 -0.2 -1.1 -1.4 -1.6 0.7 -0.0
Number of children fathered 1.5 1.7 3.6 0.7 -1.0 0.7 1.4 -1.4 -1.7 -1.3 1.9 1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 4.0 -0.2 0.6 -1.2 0.0 2.0 -0.3 0.4 0.0 -1.3
Age at first live birth 0.5 0.8 1.6 -0.5 -1.2 0.4 0.0 -0.8 -0.6 -1.2 1.1 1.2
Pulse wave peak to peak time 0.2 0.2 0.9 0.1 -0.4 0.5 0.0 -0.5 0.2 -0.6 0.2 1.0
Health satisfaction 1.0 1.3 4.0 -0.1 1.9 -0.8 -1.1 -0.0 1.0 0.7 -2.0 -0.4
Shortness of breath walking on level ground 0.3 0.3 1.0 -0.8 -0.2 -0.3 -1.0 0.3 -0.8 0.2 -0.1 -0.4
Qualifications: College or University degree 0.4 1.4 4.3 -1.0 -1.8 0.4 -2.1 -0.3 1.1 -0.9 -0.3 1.3
Eye problems/disorders: None of the above 1.1 1.2 4.9 1.5 0.6 -0.6 1.0 0.3 1.2 2.2 -0.8 0.0
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.8 1.4 -0.6 0.6 1.9 -0.5 -1.0 0.5 1.7 0.7
Emphysema/chronic bronchitis 0.4 0.5 1.8 -1.0 -0.6 0.7 -1.4 0.1 -0.0 -0.5 -0.3 -0.3
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 0.2 -1.3 -1.1 0.6 0.0 -0.6 0.2 1.3 -0.1
Neck or shoulder pain in last month 2.0 2.9 7.8 1.2 2.8 -1.9 1.0 1.0 0.8 2.4 -1.6 -1.5
Medication: Blood pressure 0.4 0.7 1.9 -0.3 -1.2 1.4 0.8 0.6 -0.2 0.2 1.0 0.8
Angina (self-reported) 0.3 0.4 1.2 -0.3 -0.6 -0.2 1.1 0.9 -0.2 0.8 0.7 0.3
Migraine (self-reported) 2.9 3.6 11.3 2.2 -0.3 -2.0 3.4 0.1 -2.2 0.3 2.5 -0.8
Medication: Ibuprofen 1.2 1.4 5.3 0.2 2.3 -0.2 0.1 0.9 1.1 0.8 -1.7 -1.2
Medication: Allopurinol 2.2 3.0 6.3 -1.6 -2.2 2.5 -1.3 -0.9 -1.1 -2.2 1.3 1.7
Medication: Omeprazole 1.9 2.2 5.1 1.2 -1.8 0.9 -0.1 -2.0 -1.3 -2.3 1.5 1.3
Medication: Seretide 50 evohaler 0.8 0.9 2.7 1.2 0.1 -0.1 1.2 -0.9 -1.6 -0.5 1.1 -0.5
Mean time to correctly identify matches 0.1 0.3 0.7 0.8 0.6 -0.6 0.8 0.2 0.0 0.6 -0.0 -0.3
Heart disease (mother) 0.3 0.3 0.7 -0.2 0.7 0.7 0.9 -0.7 0.3 -0.1 -0.3 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 2.0 6.5 0.8 0.0 -0.4 2.5 -0.1 -2.0 -1.3 2.1 -0.6
Whole body fat mass 0.2 1.0 3.5 -0.6 0.3 1.7 -0.2 -1.1 -0.4 -1.9 0.3 0.8
Leg fat mass (right) 0.2 0.7 3.2 -0.3 1.2 0.8 -0.4 -0.9 -0.3 -1.8 -0.3 0.0
Arm predicted mass (right) 0.3 1.5 5.9 0.2 2.4 -0.9 -0.9 0.2 1.2 0.2 -1.8 -1.1
Pulse rate, automated reading 0.6 1.9 4.5 -0.5 1.9 -1.0 -0.9 0.8 1.6 1.8 -2.1 -0.5
Alcohol intake frequency. 0.1 0.3 1.3 0.2 -0.1 -0.2 -0.1 0.0 -1.1 -0.6 0.6 -0.6
Comparative height size at age 10 0.1 0.7 1.6 0.7 1.2 0.9 0.7 -1.0 0.6 -0.3 -0.3 1.0
Number of full sisters 0.8 1.0 2.7 1.6 1.3 -1.2 1.5 -0.4 -0.8 0.2 0.3 -0.4
Suffer from ‘nerves’ 0.4 0.5 1.3 -0.3 -0.6 1.1 1.1 0.1 -1.0 0.7 0.7 0.4
Overall health rating 0.6 1.3 7.7 0.3 2.8 -1.0 1.5 -0.1 0.2 -0.0 -0.8 -0.3
Chest pain or discomfort 0.8 1.1 3.8 -1.1 0.1 0.2 -0.4 1.3 1.3 2.0 -1.1 0.1
Had major operations 0.6 0.8 2.2 -1.3 -0.2 0.4 -0.3 0.6 1.1 0.9 -0.4 1.5
Age at last live birth 0.1 0.2 0.6 0.5 0.5 -0.2 -0.8 -0.4 -0.0 -0.2 -0.3 -0.5
Family relationship satisfaction 0.3 0.3 2.0 -0.1 0.6 -0.1 0.2 -0.1 -0.1 -1.4 0.0 -0.8
Leg pain on walking 0.2 0.3 1.1 -0.2 0.8 -1.0 0.0 0.4 -0.5 -0.0 -0.5 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 2.6 0.6 0.4 -1.6 0.1 -0.5 0.1 -0.0 0.0 -0.6
Commuting to job workplace: Car/motor vehicle 0.6 0.7 3.0 -0.0 0.1 0.8 -0.4 -0.0 1.4 1.7 -0.9 0.1
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 7.1 1.4 -0.7 0.8 2.7 -0.8 -0.4 0.6 1.8 0.6
Medication: Aspirin 1.0 1.4 3.5 0.2 -0.7 0.8 1.2 -0.8 -1.9 -1.4 1.8 0.7
Supplements: Vitamin C 1.1 1.4 6.4 -0.3 -0.4 -0.2 2.5 -0.4 -0.4 -0.6 1.3 1.7
Knee pain experienced in last month 0.6 0.9 2.8 -0.3 1.1 -1.1 -0.6 0.7 -1.0 -0.9 -0.1 -1.7
Hypertension (Self-reported) 0.4 1.2 2.1 -1.4 -0.9 0.7 1.4 1.4 -1.2 0.3 1.4 0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.4 -0.4 -0.6 -0.0 0.1 0.3 -0.7 -0.1 0.5 0.2
Illnesses of father: Heart disease 0.8 1.2 3.3 0.5 0.2 -1.4 1.4 -1.7 0.0 -0.1 0.6 1.8
Illnesses of siblings: Diabetes 0.9 1.1 4.5 -2.1 -1.4 0.2 -1.5 1.1 0.1 0.6 -0.4 -0.0
Smoking status: Previous 3.2 4.7 10.8 1.3 -0.5 -0.4 2.9 -1.1 -3.2 -3.1 3.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.1 -0.2 0.8 -0.1 1.3 -0.5 -0.1 -0.8 0.5 1.5
Whole body fat-free mass 0.4 2.2 8.0 0.5 2.8 -1.3 -1.0 0.4 1.3 -0.0 -1.9 -1.8
Leg fat-free mass (right) 0.3 1.5 5.3 0.1 2.3 -0.9 -0.9 0.6 1.2 0.2 -1.6 -1.4
Arm fat percentage (left) 0.2 0.9 3.2 -0.8 -0.1 1.8 -0.1 -1.0 -0.4 -1.6 0.6 0.8
Average weekly red wine intake 0.2 0.4 1.7 0.9 -0.2 -1.3 0.0 -0.8 0.1 -0.1 0.3 -0.1
Handedness (chirality/laterality): Left-handed 0.8 0.9 3.0 -0.1 0.8 0.2 0.5 0.6 1.6 1.7 -1.2 0.1
Mood swings 0.1 0.3 1.0 0.4 0.9 0.1 1.0 0.3 0.1 0.4 0.1 -0.5
Loneliness, isolation 0.8 1.1 3.0 0.2 1.1 -0.5 -0.5 1.1 1.1 1.7 -1.3 -1.0
Long-standing illness, disability or infirmity 0.2 0.4 1.3 -0.8 0.2 -0.0 1.2 0.3 0.0 -0.3 0.2 1.1
Ever had bowel cancer screening 0.6 0.8 2.3 -0.6 -1.2 -0.3 0.1 1.5 -0.5 0.8 0.6 -1.1
Diabetes diagnosed by doctor 0.9 1.5 3.9 -1.8 -0.7 0.7 0.4 -0.6 -0.8 -2.0 0.9 2.0
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 4.2 1.5 -0.7 -0.1 1.9 -1.3 -1.6 -1.4 2.0 1.3
Friendships satisfaction 0.4 0.5 1.3 -0.8 0.6 -0.1 -0.9 0.7 0.5 -0.2 -1.0 -1.1
Qualifications: nursing, teaching 0.3 0.4 1.9 -0.3 0.1 0.1 0.5 -1.0 0.5 -0.1 0.2 1.4
Commuting to job workplace: Walk 0.8 0.9 2.1 -0.2 -0.6 -0.5 1.2 -1.0 -0.9 -0.9 1.1 1.4
Eye problems/disorders: Cataract 0.9 1.0 3.0 -1.2 0.5 0.8 -1.7 0.4 0.2 -1.7 -0.7 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 9.3 -1.2 -1.3 0.1 -0.5 1.4 1.4 3.1 -0.6 0.6
Medication for cholesterol 0.2 0.3 0.9 0.5 -0.0 0.3 0.1 -0.8 -0.4 -0.9 0.2 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.5 -1.4 -1.6 1.5 -0.9 0.4 0.9 0.9 -0.2 1.1
Back pain experienced in last month 1.0 1.4 3.3 0.2 1.6 -1.5 1.8 1.3 -0.1 1.5 -0.2 -0.5
Mineral and other dietary supplements 1.2 1.6 4.6 0.1 1.0 -0.2 -2.1 0.7 1.8 0.1 -2.1 -0.7
Breast cancer (self-reported) 0.9 1.1 4.2 -0.6 -1.0 -1.3 -2.1 0.8 0.4 0.7 -1.1 -0.7
Asthma (self-reported) 1.0 2.1 6.7 1.3 0.4 -1.5 -0.1 0.3 -2.6 -1.3 1.3 -2.1
Osteoporosis (self-reported) 0.9 1.2 5.0 -0.0 0.1 -1.6 0.5 1.3 0.6 2.2 -0.5 -0.5
Osteoarthritis (self-reported) 1.1 1.5 6.6 0.8 0.3 -0.4 -0.4 -2.6 -1.1 -2.0 0.6 0.2
Medication: Aspirin 1.2 1.5 4.1 0.4 -0.7 0.8 1.5 -0.9 -2.0 -0.9 2.0 0.7
Medication: Gliclazide 0.6 0.7 2.0 -1.4 0.2 1.4 0.4 -0.3 0.3 -0.6 -0.0 1.4
Illnesses of father: None of the above (group 1) 1.3 1.6 4.4 -1.3 -0.7 0.8 -2.0 2.1 0.3 0.3 -0.9 -1.4
Smoking status: Current 0.6 0.9 2.4 -0.7 1.4 -1.2 0.8 0.3 0.8 1.6 -0.8 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 5.2 0.2 1.7 -2.3 0.2 -0.2 0.6 -0.6 -1.0 0.1
Whole body water mass 0.4 2.3 8.4 0.6 2.9 -1.3 -0.9 0.5 1.4 0.1 -1.9 -1.9
Leg predicted mass (right) 0.3 1.5 5.3 0.1 2.3 -0.9 -0.9 0.7 1.2 0.2 -1.6 -1.4
Arm fat mass (left) 0.1 0.5 1.8 -0.6 0.6 1.2 -0.3 -0.7 0.0 -1.3 -0.1 0.3
Number of self-reported non-cancer illnesses 1.0 1.7 3.5 0.2 -1.2 1.2 0.9 -1.7 -1.2 -1.1 1.6 1.9
Average weekly champagne plus white wine intake 0.7 1.0 3.3 1.6 -0.5 0.7 0.0 0.1 1.3 1.8 -0.4 -0.8
Miserableness 1.3 2.2 8.1 1.6 1.6 -0.9 0.4 0.4 -1.9 -1.3 0.4 -2.8
Guilty feelings 0.5 0.7 3.1 -0.3 1.8 -0.1 -0.1 1.0 0.2 -0.0 -0.9 -1.3
Wears glasses or contact lenses 0.4 0.5 1.7 -0.6 -0.2 1.3 0.9 -0.5 -0.4 -0.3 0.6 0.7
Ever taken oral contraceptive pill 0.6 0.7 3.6 0.2 1.9 -0.4 0.8 -0.4 0.5 -0.9 -0.5 -0.2
Hearing aid user 0.9 1.0 3.2 -1.8 -0.1 0.3 -0.5 0.5 1.3 0.4 -1.1 1.4
Mother’s age at death 0.2 0.2 0.5 0.7 0.7 -0.7 -0.2 -0.2 0.1 0.2 -0.3 -0.4
Financial situation satisfaction 0.6 0.7 1.8 -0.8 1.0 0.5 -1.2 0.5 1.0 -0.1 -1.3 -0.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.4 -0.6 -0.6 0.4 1.6 0.5 0.3 1.1 0.7 0.5
Commuting to job workplace: Public transport 1.0 1.2 3.1 -1.8 -1.4 1.2 -1.1 1.2 0.8 -0.1 -0.4 0.5
Eye problems/disorders: Glaucoma 1.2 1.5 4.5 -2.1 -1.0 1.2 -1.6 -0.5 0.9 0.1 -0.7 1.4
Medication: Blood pressure 0.1 0.3 1.0 -0.3 0.2 -0.0 0.6 0.4 -1.0 -0.2 0.7 -0.5
Pain type(s) experienced in last month: Hip pain 1.0 1.3 4.8 -0.1 1.3 -1.7 -0.6 0.9 -0.6 -0.4 -0.5 -2.2
Supplements: Fish oil (including cod liver oil) 4.0 5.2 14.4 0.2 -2.1 0.5 3.2 -1.6 -3.0 -1.5 3.8 1.7
High cholesterol (Self-reported) 1.3 2.3 9.2 -3.0 -2.1 1.5 -1.4 1.6 0.2 -0.0 -0.2 0.5
Medication: Bendroflumethiazide 0.5 0.7 1.7 0.3 -0.9 1.0 1.2 -0.1 -0.9 -0.5 1.3 0.7
Medication: Paracetamol 0.5 0.8 2.4 0.4 0.7 -0.6 -1.0 0.6 0.7 0.9 -1.2 -1.6
Medication: Lisinopril 0.8 1.0 2.9 -1.0 0.4 0.2 -1.1 1.7 0.8 0.9 -1.0 -1.3
Medication: Atorvastatin 1.3 1.6 5.3 -2.2 -1.5 1.1 -0.2 -0.7 0.2 0.7 0.3 2.3
Illnesses of father: High blood pressure 0.9 1.2 2.1 -0.4 1.4 -1.4 0.3 1.1 1.4 1.1 -1.3 -0.1
Alcohol drinker status: Never 1.3 1.6 4.5 1.1 0.8 -1.7 -1.2 0.2 -1.4 -0.9 -0.2 -2.1
Ever smoked 0.8 1.4 3.4 -0.3 -0.4 -0.1 1.8 0.1 -1.7 -1.5 1.8 -0.6
Basal metabolic rate 0.3 1.7 5.9 0.1 2.4 -0.8 -1.1 0.4 1.2 -0.3 -1.8 -1.5
Leg fat percentage (left) 0.2 0.8 3.6 -0.7 0.3 1.2 -0.6 -1.0 -0.4 -1.9 0.0 0.4
Arm fat-free mass (left) 0.4 2.1 8.0 0.5 2.8 -1.2 -0.9 0.2 1.2 -0.1 -2.0 -1.7
Number of operations (self-reported) 1.9 2.8 7.1 -2.7 -0.6 0.7 -0.5 1.8 1.9 2.0 -1.2 2.2
Average weekly beer plus cider intake 1.1 1.5 5.2 -0.8 2.3 -1.1 0.8 1.9 0.3 0.5 -0.9 -1.2
Irritability 0.3 0.4 1.9 0.5 -0.0 1.4 0.2 -0.5 -1.0 0.0 0.7 0.0
Risk taking 0.1 0.1 0.8 0.2 0.5 -0.1 -0.1 -0.9 -0.2 -0.3 -0.1 -0.1
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.7 1.2 0.3 -0.8 -0.9 0.0 0.2 0.5 -0.9 -1.3
Fractured/broken bones in last 5 years 1.0 1.3 6.5 -1.5 -0.6 0.8 -0.1 0.1 1.2 0.2 -0.5 2.5
Age started oral contraceptive pill 0.4 0.5 1.5 -0.8 -1.2 1.0 -0.0 0.6 -0.5 0.2 0.7 -0.1
Diastolic blood pressure, automated reading 0.3 1.0 4.2 0.3 0.4 -1.2 0.5 1.4 -0.4 1.1 0.3 -2.0
Ever depressed for a whole week 1.1 1.4 3.3 0.4 1.5 -1.5 -0.9 0.3 1.7 -0.1 -1.8 -1.1
Unable to work because of sickness or disability 0.7 1.0 5.5 -2.4 -0.4 0.5 -0.4 0.9 -0.0 -0.5 -0.1 1.2
Commuting to job workplace: Cycle 1.7 2.1 4.9 0.9 -1.8 1.0 -0.5 -2.2 -1.4 -1.6 1.6 1.1
Myopia 0.3 0.4 2.3 -0.6 -0.0 -0.8 0.2 0.1 -0.4 -1.5 0.5 -0.1
Vascular/heart problems diagnosed by doctor 0.5 1.5 3.9 2.0 1.4 -1.1 -1.1 -1.4 0.7 -0.7 -1.2 -0.7
Cholesterol lowering medication 0.8 1.1 3.5 -1.4 -1.9 1.6 -0.8 0.6 0.7 0.7 0.2 0.3
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 6.2 0.8 -0.9 0.8 -1.2 -1.8 -0.3 -2.5 0.3 1.0
Pain experienced in last month 1.2 2.0 4.3 -0.2 -1.7 2.1 -0.8 -2.0 0.9 -1.5 0.5 1.6
Supplements: Calcium 0.9 1.0 2.3 -1.1 -0.1 -0.9 -0.2 1.5 -1.0 -1.3 0.2 -1.2
Basal cell carcinoma (self-reported) 1.9 2.3 6.2 0.9 -1.0 0.4 2.1 -1.2 -2.2 -1.3 2.5 0.8
Heart attack/myocardial infarction (self-reported) 1.2 1.5 5.2 1.0 0.5 0.6 2.3 -1.8 -0.3 -0.0 0.9 1.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.4 -1.0 -0.0 1.5 -1.1 -0.2 0.8 -1.4 -0.6 0.8
Heart disease (siblings) 0.6 0.7 1.8 0.4 1.0 -0.4 1.4 -1.2 0.2 0.4 -0.1 1.3
Alcohol drinker status: Previous 0.7 0.8 4.1 -2.0 -0.9 0.1 0.5 0.8 0.1 -0.2 0.5 1.0
Pack years of smoking 1.3 1.8 6.3 -0.8 0.5 -0.3 -2.5 1.7 0.2 0.9 -1.5 -1.8
Impedance of whole body 1.9 9.8 25.7 -2.8 -5.1 4.3 0.9 -0.6 -1.2 -1.0 3.1 4.8
Leg fat mass (left) 0.2 0.6 2.7 -0.4 1.2 0.6 -0.4 -0.7 -0.3 -1.7 -0.3 -0.0
Arm predicted mass (left) 0.5 2.3 8.4 0.6 2.9 -1.5 -0.8 0.5 1.1 0.1 -1.9 -2.0