Hub : Genes

SOX8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.1308 0.0354 2.3e-05 0.056 0.036 0.050 0.047 0.052 8.3e-09 3.3e-06 5.7e-08 1.1e-07 2.9e-08
2 YFS Blood 0.0538 0.0152 1.9e-06 0.001 0.018 0.019 0.019 0.002 1.2e-01 1.1e-06 6.7e-07 5.6e-07 7.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.3 -0.3 0.5
Bipolar Disorder or Schizophrenia 0.7 1.7 3.2 -1.8 0.5
Depressed Affect (Nagel 2018) 0.2 0.3 0.6 -0.1 -0.8
Depression (Nagel 2018) 1.2 1.8 3.2 -1.8 -0.6
Intelligence (Savage-Jansen 2018) 6.5 19.8 33.8 2.4 5.8
Neuroticism (Nagel 2018) 0.2 0.6 0.8 0.9 -0.6
Schizophrenia (2018) 1.1 2.2 4.3 -2.1 -0.3
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.9 1.8 2.4 1.5 1.1
Alzheimer’s Disease (in mother) 0.6 0.7 1.1 -0.5 1.0
Alzheimer’s Disease (in father) 2.0 2.1 3.2 1.1 1.8
Alzheimer’s Disease (including proxy) 0.8 1.2 2.4 0.1 1.5
Crohns Disease (2017) 0.1 0.3 0.4 0.4 -0.7
Irritable Bowel Disease (IBD) 0.2 0.5 0.6 -0.6 -0.8
Ulcerative Colitis (UC) 0.4 0.8 1.1 -1.0 -0.7
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.9 3.7 7.3 -2.7 -0.3
Verbal and Numeric Reasoning (VNR) 3.9 9.2 14.5 2.0 3.8
Breast Cancer 0.8 1.8 3.2 0.7 -1.8
Ovarian Cancer 0.4 0.5 1.0 1.0 -0.3
Prostate Cancer 1.1 1.5 3.0 -1.7 -0.2
Age at First Birth 1.1 1.6 2.8 0.7 1.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 0.0 -0.4
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.6 2.6 4.4 0.8 -2.1
Mean Putamen Volume 0.2 0.3 0.5 0.0 0.7
Fasting Glucose 0.2 0.2 0.4 0.6 -0.3
HbA1C 1.5 1.6 3.0 -0.6 -1.7
HDL Cholesterol 0.4 0.7 1.2 1.1 -0.4
LDL Cholesterol 0.5 0.7 1.4 -1.2 0.3
Lupus 0.8 1.3 1.8 -1.3 -0.9
Neuroticism (2016) 1.9 2.7 4.4 1.0 -2.1
Primary Biliary Cirrhosis 0.2 0.3 0.4 -0.6 0.5
Rheumatoid Arthritis 1.2 1.6 2.4 1.6 -0.9
Schizophrenia (2014) 0.9 2.1 3.5 -1.9 -0.8
Triglycerides 0.0 0.1 0.1 -0.2 0.3
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.8 1.1 2.0 -1.4 0.5
Blood Eosinophil Count 0.0 0.2 0.3 0.6 0.2
Blood Platelet Count 0.5 5.5 5.7 2.4 -2.3
Blood Red Count 0.3 2.7 5.4 0.2 -2.3
Blood White Count 0.0 0.2 0.2 0.4 -0.4
Heel T-Score 0.7 5.8 8.1 -2.8 1.9
BMI 0.9 5.4 9.5 -1.1 -3.1
Height 1.3 25.6 51.3 7.2 -0.0
Waist Hip Ratio (WHR) 0.4 1.7 2.8 -0.7 -1.7
Systolic Blood Pressure 1.2 5.9 9.7 1.5 3.1
Smoking Status 0.4 1.1 1.4 0.8 -1.2
Allergy or Eczema 0.1 0.3 0.7 -0.8 0.0
Cardiovascular Disease 0.3 0.9 1.6 1.3 -0.4
Hypothyroidism (self reported) 2.3 5.3 9.3 3.0 1.2
Respiratory disease 0.8 1.9 3.2 1.8 0.7
Type 2 Diabetes (T2D) (2018) 0.9 1.8 3.2 -0.6 -1.8
Lung FEV1/FVC ratio 0.5 2.8 3.9 -1.3 -2.0
Lung FVC 0.1 0.6 1.0 0.5 1.0
Neuroticism 1.0 2.4 2.5 1.6 -1.5
Chronotype (morning person) 1.4 3.3 5.5 -2.3 1.1
Hair Pigment 0.0 1.1 1.8 -0.6 -1.3
Tanning 0.0 0.0 0.0 0.1 0.1
Hand grip strength (left) 0.4 0.9 1.9 1.4 -0.0
Number of treatments/medications taken 1.9 3.4 3.8 -1.9 -1.7
Average weekly spirits intake 0.2 0.3 0.4 0.6 0.4
Sensitivity / hurt feelings 1.0 1.7 2.0 1.4 -1.2
Frequency of depressed mood in last 2 weeks 0.9 1.3 1.7 -1.3 -0.9
Hearing difficulty/problems: Yes 0.1 0.1 0.1 -0.4 -0.2
Relative age of first facial hair 1.6 3.4 6.7 0.0 2.6
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 0.1 0.5
Ever used hormone-replacement therapy (HRT) 2.8 3.6 6.8 -0.6 -2.6
Ever had hysterectomy (womb removed) 3.0 3.3 6.7 -0.2 -2.6
Systolic blood pressure, automated reading 0.5 1.5 1.6 1.2 1.2
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 1.5 -1.2 -1.1
Angina 0.1 0.1 0.1 -0.4 -0.2
Medication for hormone replacement therapy 0.6 0.7 1.2 0.3 -1.1
Vitamin and mineral supplements 0.7 1.0 1.3 -1.1 0.9
Supplements: Zinc 0.2 0.2 0.3 -0.4 0.5
Medication: Co-codamol 0.1 0.1 0.2 0.3 0.4
Medication: Metformin 0.5 0.8 1.3 -0.4 -1.2
Diabetes (father) 0.7 0.8 1.3 0.6 -1.1
Diabetes (mother) 1.4 1.8 3.3 -1.8 -0.5
Severe depression (siblings) 0.2 0.2 0.3 0.6 -0.4
Pack years adult smoking proportion 0.1 0.1 0.1 -0.4 0.2
Impedance of leg (right) 0.6 2.8 3.6 1.9 1.4
Leg fat-free mass (left) 0.5 2.8 4.7 1.0 -2.2
Trunk fat percentage 0.1 0.4 0.5 -0.6 -0.7
Hand grip strength (right) 0.2 0.7 1.1 0.4 1.1
Townsend deprivation index at recruitment 2.4 3.4 3.6 1.9 -1.8
Current tobacco smoking 0.9 1.5 3.0 0.2 -1.7
Average weekly fortified wine intake 2.1 2.4 4.3 -2.1 0.8
Maternal smoking around birth 3.6 5.2 9.4 -3.1 -1.0
Fed-up feelings 0.6 1.2 2.1 -0.5 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.8 3.5 -1.9 0.1
Relative age voice broke 1.2 1.8 2.8 0.9 1.7
Taking other prescription medications 1.1 1.8 2.4 -1.6 -1.1
Age when periods started (menarche) 0.4 0.9 1.8 0.1 1.3
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.3 -0.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.8 -1.7 0.3
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.1 -1.4 -0.5
Qualifications: CSEs or equivalent 1.3 1.7 2.3 -1.0 -1.5
Serious illness, injury or assault to yourself 2.4 3.0 5.6 -0.6 -2.4
High blood pressure 0.5 1.5 3.0 1.7 -0.2
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.2 -0.5 0.3
Multivitamins +/- minerals 0.6 0.8 1.5 0.2 -1.2
Stomach or abdominal pain in last month 1.2 1.5 2.8 -1.7 -0.4
Supplements: Glucosamine 0.3 0.4 0.7 0.8 -0.0
Diverticular disease/diverticulitis (self-reported) 2.6 3.1 3.1 1.7 1.8
Medication: Atenolol 1.7 2.1 4.1 -0.3 2.0
Medication: Levothyroxine sodium 1.8 3.0 4.2 2.0 1.4
Sitting height 0.3 1.9 3.7 1.9 -0.4
Chronic bronchitis/emphysema (father) 1.8 2.1 2.2 1.5 -1.4
High blood pressure (mother) 0.2 0.3 0.3 -0.5 -0.6
Body mass index (BMI) 1.2 5.2 8.1 -1.5 -2.9
Impedance of leg (left) 0.4 2.0 3.4 1.9 0.8
Leg predicted mass (left) 0.5 2.8 4.8 0.9 -2.2
Trunk fat mass 0.3 1.2 2.4 -0.0 -1.6
Waist circumference 1.2 4.2 8.0 -0.7 -2.8
Number of incorrect matches in round 0.1 0.1 0.2 0.0 -0.4
Past tobacco smoking 0.3 0.6 1.1 -1.0 -0.2
Alcohol usually taken with meals 0.8 1.3 1.4 -1.1 1.2
Nervous feelings 1.3 2.4 4.4 2.1 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.6 -0.6 0.8
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.3 -0.4
Hair/balding pattern: Pattern 2 0.6 0.8 1.5 0.3 1.2
Had menopause 3.2 4.0 5.6 2.4 -1.6
Had other major operations 2.0 2.4 2.7 -1.7 -1.5
Forced vital capacity (FVC) 0.4 1.4 2.6 1.6 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 3.7 -1.9 0.7
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.3 -0.6 -0.5
Qualifications: None of the above 1.1 2.4 3.6 -1.0 -1.9
Financial difficulties in last 2 years 1.4 1.9 3.5 -0.5 -1.9
Mouth/teeth dental problems 1.4 2.2 4.2 -2.0 0.5
Heart attack 0.3 0.3 0.4 0.5 -0.6
Allergy 0.2 0.4 0.7 0.8 0.2
Pain all over the body in last month 0.5 0.5 0.6 0.6 -0.8
Diabetes (self-reported) 0.1 0.1 0.2 -0.1 -0.4
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 4.7 -1.0 2.2
Medication: Ramipril 1.2 1.5 2.9 0.4 1.7
Medication: Simvastatin 0.1 0.1 0.1 0.3 0.4
Fluid intelligence score 3.1 6.4 10.2 1.6 3.2
Illnesses of siblings 0.1 0.1 0.1 -0.2 -0.4
Neuroticism score 0.8 1.6 1.7 1.2 -1.3
Weight 0.9 4.4 8.1 0.8 -2.8
Impedance of arm (right) 2.3 10.5 21.0 0.3 4.6
Arm fat percentage (right) 0.8 3.3 6.0 -2.4 -0.8
Trunk fat-free mass 1.2 6.6 9.7 1.9 -3.1
Hip circumference 0.3 1.1 2.3 -0.1 -1.5
Time employed in main current job 1.4 1.6 3.0 1.7 -0.5
Alcohol intake versus 10 years previously 1.8 2.6 4.0 2.0 -1.1
Father’s age at death 1.7 2.3 3.6 1.0 1.9
Worrier / anxious feelings 0.1 0.2 0.4 0.3 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.0 1.0 -0.8
Falls in the last year 0.2 0.3 0.4 0.5 -0.6
Hair/balding pattern: Pattern 3 1.0 1.5 3.0 -1.7 0.1
Number of live births 0.0 0.0 0.0 -0.1 -0.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 0.4 0.0
Pulse rate 1.1 1.9 2.4 1.2 -1.6
Happiness 0.1 0.1 0.1 -0.3 0.3
Noisy workplace 3.1 3.8 6.1 -1.2 -2.5
Qualifications: A levels/AS levels or equivalent 3.2 7.1 13.5 0.8 3.7
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 0.0 -0.0
Mouth/teeth dental problems: Dentures 0.6 1.0 1.7 1.3 -0.6
Asthma 0.9 1.7 2.2 1.1 1.5
Medication: Ibuprofen (e.g. Nurofen) 5.3 6.8 11.9 -1.3 -3.4
Medication: Cholesterol lowering 0.5 0.7 1.4 -0.3 1.2
Depression (self-reported) 1.0 1.2 1.3 -1.0 1.1
Medication: Lansoprazole 0.6 0.7 1.0 -1.0 -0.6
Prospective memory result 0.7 0.9 1.7 0.2 -1.3
Lung cancer (father) 0.9 1.0 1.7 0.6 1.3
Illnesses of mother 1.0 1.2 2.0 1.4 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.1 0.4
Pulse wave Arterial Stiffness index 0.6 0.7 1.5 -1.2 0.1
Impedance of arm (left) 2.8 12.9 24.9 0.9 5.0
Arm fat mass (right) 0.7 2.8 3.9 -1.3 -2.0
Trunk predicted mass 1.2 6.8 10.0 1.9 -3.2
Standing height 1.4 13.6 27.1 5.2 0.2
Length of working week for main job 2.1 2.4 4.1 2.0 -0.8
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.2 -0.5
Breastfed as a baby 0.4 0.5 0.9 0.1 1.0
Tense / ‘highly strung’ 0.5 0.8 1.7 1.3 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.6 -0.6 1.6
Hair/balding pattern: Pattern 4 0.5 1.2 1.7 1.3 0.9
Birth weight of first child 0.5 0.9 1.2 -0.8 -1.1
Peak expiratory flow (PEF) 1.1 2.6 3.8 -1.9 1.1
Pulse wave reflection index 0.7 0.8 1.1 -0.8 1.0
Ever highly irritable/argumentative for 2 days 2.1 2.5 3.4 -1.9 -1.3
Loud music exposure frequency 1.0 1.1 1.8 -1.3 -0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.7 0.8 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.1 1.0 -0.6
Blood clot in the leg (DVT) 1.4 1.8 3.2 -0.6 -1.8
Medication: Paracetamol 1.8 3.0 5.5 -0.7 -2.4
Headache pain in last month 3.7 6.3 7.0 -2.4 -2.6
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.3 -0.5 -1.5
Glaucoma (self-reported) 2.6 3.1 5.6 -0.7 2.4
Gout (self-reported) 0.1 0.1 0.2 -0.0 0.5
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 4.4 2.1 1.0
Medication: Amlodipine 0.1 0.1 0.2 -0.3 0.4
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.8 0.5 1.4
Birth weight 0.1 0.2 0.3 0.2 -0.6
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 1.0 -0.2
High blood pressure (siblings) 0.4 0.6 1.1 1.0 -0.2
Forced vital capacity (FVC), Best measure 0.4 1.4 1.4 1.2 1.1
Body fat percentage 0.4 1.4 2.0 -0.9 -1.4
Leg fat percentage (right) 1.3 4.8 9.1 -0.7 -3.0
Arm fat-free mass (right) 1.9 9.7 13.5 2.4 -3.7
Exposure to tobacco smoke outside home 1.8 2.4 4.5 0.5 -2.1
Comparative body size at age 10 0.9 2.5 4.9 -0.1 -2.2
Number of full brothers 0.4 0.5 0.9 -0.2 -1.0
Worry too long after embarrassment 0.3 0.5 1.0 -0.0 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 -0.3 -0.6
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 -0.0 0.2
Number of children fathered 0.6 0.7 1.1 -1.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 2.0 1.1 -1.4
Age at first live birth 1.5 2.6 3.0 -1.5 1.7
Pulse wave peak to peak time 1.1 1.2 2.4 1.6 -0.2
Health satisfaction 0.3 0.4 0.6 0.4 -0.8
Shortness of breath walking on level ground 0.3 0.4 0.6 -0.5 -0.8
Qualifications: College or University degree 2.3 7.3 14.4 0.5 3.8
Eye problems/disorders: None of the above 2.6 3.0 5.7 2.4 -0.6
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.4 0.7 0.5
Emphysema/chronic bronchitis 1.2 1.4 2.5 1.6 -0.5
Medication for pain relief, constipation, heartburn 3.2 5.5 6.7 2.1 2.6
Neck or shoulder pain in last month 1.3 1.9 2.5 -1.6 -1.1
Medication: Blood pressure 1.8 3.2 5.2 1.1 2.3
Angina (self-reported) 0.2 0.2 0.4 -0.7 -0.2
Migraine (self-reported) 2.2 2.8 5.4 -0.5 -2.3
Medication: Ibuprofen 4.2 5.0 9.3 -0.9 -3.0
Medication: Allopurinol 0.3 0.4 0.7 0.1 0.9
Medication: Omeprazole 1.3 1.6 2.9 -1.7 -0.5
Medication: Seretide 50 evohaler 4.4 5.1 9.7 -3.1 0.7
Mean time to correctly identify matches 1.5 2.8 5.3 -2.3 -0.6
Heart disease (mother) 0.7 0.9 1.0 -1.0 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 2.5 -0.7 -1.6
Whole body fat mass 0.5 2.2 4.2 -0.3 -2.1
Leg fat mass (right) 1.2 4.6 9.1 0.0 -3.0
Arm predicted mass (right) 1.8 9.3 14.3 2.1 -3.8
Pulse rate, automated reading 0.4 1.3 2.1 0.7 -1.5
Alcohol intake frequency. 0.5 1.1 1.1 -1.1 -1.0
Comparative height size at age 10 1.8 10.1 20.1 4.5 -0.2
Number of full sisters 1.1 1.3 2.4 1.6 0.5
Suffer from ‘nerves’ 1.1 1.8 3.4 1.8 0.5
Overall health rating 0.7 1.6 3.0 0.5 -1.7
Chest pain or discomfort 0.9 1.2 1.5 -1.0 -1.2
Had major operations 0.4 0.5 0.6 -0.8 -0.5
Age at last live birth 0.9 1.4 2.7 -1.6 0.1
Family relationship satisfaction 0.2 0.2 0.3 -0.6 -0.3
Leg pain on walking 0.5 0.6 1.0 -0.5 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.4 0.7 -1.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.2 -0.1 -1.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.1 0.5
Medication: Aspirin 0.0 0.0 0.0 -0.1 0.2
Supplements: Vitamin C 0.3 0.4 0.7 0.8 -0.2
Knee pain experienced in last month 3.9 6.1 10.6 1.2 -3.2
Hypertension (Self-reported) 0.4 1.2 2.0 1.4 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.5 4.4 -0.8 -2.1
Illnesses of father: Heart disease 0.7 0.9 1.6 -1.3 -0.5
Illnesses of siblings: Diabetes 1.5 1.8 1.8 1.4 -1.4
Smoking status: Previous 0.2 0.4 0.7 0.8 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 0.7 -0.1
Whole body fat-free mass 0.9 5.4 8.4 1.6 -2.9
Leg fat-free mass (right) 0.6 3.0 5.0 1.0 -2.2
Arm fat percentage (left) 0.6 2.3 4.2 -2.1 -0.7
Average weekly red wine intake 1.0 1.5 2.6 1.6 0.6
Handedness (chirality/laterality): Left-handed 2.2 2.6 5.2 2.3 0.1
Mood swings 0.9 1.6 3.1 0.3 -1.7
Loneliness, isolation 0.7 1.0 1.3 -0.8 -1.2
Long-standing illness, disability or infirmity 0.2 0.2 0.4 0.3 -0.6
Ever had bowel cancer screening 0.6 0.6 1.3 1.1 0.2
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.6 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.3 -0.6 1.5
Friendships satisfaction 0.4 0.4 0.6 -0.5 0.8
Qualifications: nursing, teaching 0.9 1.4 2.8 0.1 1.7
Commuting to job workplace: Walk 0.5 0.5 0.6 0.7 0.8
Eye problems/disorders: Cataract 1.0 1.1 1.3 -1.0 1.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.1 -0.4
Medication for cholesterol 0.3 0.4 0.9 0.1 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 2.8 -0.4 -1.7
Back pain experienced in last month 3.9 5.6 6.4 2.2 -2.5
Mineral and other dietary supplements 0.5 0.7 0.9 -1.0 -0.6
Breast cancer (self-reported) 1.2 1.4 2.8 -1.7 -0.2
Asthma (self-reported) 1.1 2.1 2.8 1.2 1.7
Osteoporosis (self-reported) 0.4 0.5 0.6 0.6 0.8
Osteoarthritis (self-reported) 5.2 6.8 9.2 -2.1 -3.0
Medication: Aspirin 0.1 0.2 0.3 0.1 0.6
Medication: Gliclazide 1.5 1.7 2.3 -1.1 -1.5
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 -0.2 0.4
Smoking status: Current 0.8 1.3 2.5 0.3 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.1 -0.3 -0.3
Whole body water mass 1.0 5.5 8.5 1.6 -2.9
Leg predicted mass (right) 0.5 2.9 4.8 1.0 -2.2
Arm fat mass (left) 0.5 1.9 2.9 -1.0 -1.7
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 -0.2 0.6
Average weekly champagne plus white wine intake 1.8 2.5 3.5 -1.9 1.2
Miserableness 0.3 0.5 0.9 0.3 -1.0
Guilty feelings 0.1 0.1 0.1 0.3 -0.4
Wears glasses or contact lenses 0.9 1.1 2.1 0.1 1.5
Ever taken oral contraceptive pill 0.0 0.1 0.1 -0.2 -0.3
Hearing aid user 0.2 0.2 0.3 0.6 -0.4
Mother’s age at death 1.3 1.7 2.9 0.6 1.7
Financial situation satisfaction 2.7 3.3 6.3 -2.5 -0.6
Tinnitus: Yes, now most or all of the time 0.9 1.1 1.5 -0.8 -1.2
Commuting to job workplace: Public transport 1.4 1.7 2.3 1.5 1.0
Eye problems/disorders: Glaucoma 1.6 1.9 2.1 -1.3 1.5
Medication: Blood pressure 0.3 0.5 0.7 0.6 -0.9
Pain type(s) experienced in last month: Hip pain 0.9 1.1 1.2 -1.0 -1.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 1.0 -0.1
High cholesterol (Self-reported) 0.2 0.3 0.6 0.0 0.8
Medication: Bendroflumethiazide 0.1 0.1 0.1 -0.3 -0.4
Medication: Paracetamol 3.3 5.1 5.5 -2.3 -2.2
Medication: Lisinopril 0.5 0.7 1.1 -1.1 -0.4
Medication: Atorvastatin 1.3 1.6 2.7 -1.6 0.6
Illnesses of father: High blood pressure 0.6 0.7 1.4 -0.0 -1.2
Alcohol drinker status: Never 0.7 0.8 1.6 0.2 -1.2
Ever smoked 0.3 0.5 0.9 0.9 0.1
Basal metabolic rate 1.0 5.3 8.9 1.3 -3.0
Leg fat percentage (left) 1.8 6.6 12.7 -0.7 -3.6
Arm fat-free mass (left) 1.9 9.5 16.2 1.7 -4.0
Number of operations (self-reported) 1.4 2.1 2.5 -1.3 -1.6
Average weekly beer plus cider intake 2.4 3.4 4.6 1.5 -2.1
Irritability 0.7 1.2 1.9 0.7 -1.4
Risk taking 0.3 0.4 0.7 -0.5 -0.8
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.2 -1.5 -0.4
Fractured/broken bones in last 5 years 1.6 2.1 3.1 -1.0 -1.8
Age started oral contraceptive pill 0.5 0.6 1.2 1.1 -0.2
Diastolic blood pressure, automated reading 0.4 1.3 1.5 1.0 -1.2
Ever depressed for a whole week 0.5 0.7 1.3 1.1 -0.2
Unable to work because of sickness or disability 0.2 0.3 0.6 -0.2 -0.7
Commuting to job workplace: Cycle 1.5 1.8 3.4 -0.5 1.8
Myopia 2.3 3.3 5.3 2.3 1.2
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.1 -1.8 0.2
Cholesterol lowering medication 0.2 0.3 0.4 -0.5 0.6
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 3.0 -1.7 -0.8
Pain experienced in last month 1.6 2.7 5.1 -0.5 2.3
Supplements: Calcium 0.7 0.8 1.3 1.1 -0.5
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 -0.9 0.1
Heart attack/myocardial infarction (self-reported) 0.9 1.1 1.2 1.0 -1.1
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 3.0 -0.9 -1.7
Heart disease (siblings) 4.9 6.0 10.8 -3.3 1.1
Alcohol drinker status: Previous 1.4 1.6 2.4 -1.6 0.8
Pack years of smoking 0.0 0.0 0.0 -0.0 0.2
Impedance of whole body 1.5 7.6 13.3 1.4 3.6
Leg fat mass (left) 1.4 5.5 11.0 -0.1 -3.3
Arm predicted mass (left) 1.6 8.3 13.2 1.8 -3.6