TWAS hub - SP140

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0269	0.0092	0.00027	0.000	0.013	0.009	0.013	0.002	0.230	2.7e-05	0.0006	2.7e-05	0.046
2	TCGA	Brain Lower Grade Glioma	0.0392	0.0214	0.00860	0.002	0.004	0.003	NA	-0.001	0.190	1.1e-01	0.1300	NA	0.430
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.0680	0.0340	0.00500	0.014	0.004	-0.004	NA	0.000	0.037	1.7e-01	0.8800	NA	0.330

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Crohns Disease (2017)	8.7	19.0	28.6	-5.3	0.1	-5.3
Crohns Disease (2012)	5.8	9.3	15.1	-3.9	0.3	-3.6
Irritable Bowel Disease (IBD)	4.0	9.6	17.8	-4.2	-0.7	-3.2
Exposure to tobacco smoke at home	3.6	4.1	6.2	1.4	-2.5	2.0
Family relationship satisfaction	3.6	4.4	12.4	-3.5	0.1	-0.9
Average weekly spirits intake	3.5	4.4	8.3	0.1	-2.2	2.9
Mean Putamen Volume	3.2	3.7	4.7	-2.2	1.7	-1.8
Myopia	3.2	4.6	7.9	-2.8	0.2	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.7	5.7	-2.4	-2.1	0.9
Hand grip strength (left)	3.0	8.0	10.0	-2.3	2.9	-3.2
Supplements: Zinc	3.0	3.3	5.0	-2.2	1.3	-1.8
Blood Eosinophil Count	2.7	20.6	36.8	-3.8	3.2	-6.1
Systolic blood pressure, automated reading	2.5	7.4	10.2	3.2	2.6	2.3
Emphysema/chronic bronchitis	2.3	2.6	6.0	1.0	-0.8	2.5
HbA1C	2.1	2.4	3.4	1.8	-1.3	1.4
Smoking status: Current	2.1	3.4	6.3	-2.5	0.9	-1.7
Loud music exposure frequency	2.0	2.2	3.1	0.8	-1.7	1.8
Financial situation satisfaction	2.0	2.5	5.0	0.6	-1.4	2.2
Diastolic blood pressure, automated reading	1.9	6.0	10.7	3.3	2.4	1.3
Schizophrenia (2018)	1.8	3.8	7.8	0.9	-1.6	2.8
Coronary Artery Disease (CAD)	1.8	2.1	4.4	-0.9	1.0	-2.1
Smoking Status	1.8	4.2	8.8	-3.0	1.2	-1.6
Diabetes (father)	1.8	2.3	6.2	2.5	-0.1	0.8
Current tobacco smoking	1.8	3.0	5.4	-2.3	0.8	-1.7
Heart disease (mother)	1.7	2.1	3.2	-0.3	1.7	-1.8
Suffer from ‘nerves’	1.7	2.6	4.8	1.3	-1.2	2.2
Medication: Seretide 50 evohaler	1.6	1.9	5.3	0.2	2.3	-0.5
Friendships satisfaction	1.6	2.0	5.2	-2.3	0.8	0.4
Mother’s age at death	1.6	2.0	3.2	-1.8	0.9	-1.4
Commuting to job workplace: Cycle	1.6	1.9	3.9	0.4	2.0	-1.3
Alzheimer’s Disease (in mother)	1.5	1.7	3.1	0.7	-1.8	1.2
Stomach or abdominal pain in last month	1.5	1.8	2.7	-1.2	1.6	-1.2
Falls in the last year	1.5	2.1	3.9	0.6	-1.4	2.0
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.7	-1.4	-1.6	0.8
Commuting to job workplace: Walk	1.5	1.6	3.2	1.8	1.3	0.1
Arm fat mass (left)	1.5	6.0	15.2	3.9	1.2	1.2
Fasting Glucose	1.4	1.7	3.2	1.1	-1.8	0.9
Mouth/teeth dental problems	1.4	2.1	4.5	2.1	-0.4	1.3
Arm fat mass (right)	1.4	5.6	14.3	3.8	1.0	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.7	1.9	-0.0	1.6
Age started oral contraceptive pill	1.4	1.7	4.6	2.1	0.1	0.7
Blood Red Count	1.3	12.2	28.5	-0.1	5.3	-2.8
Systolic Blood Pressure	1.3	6.3	8.7	2.6	1.9	3.0
Medication: Co-codamol	1.3	1.5	2.2	0.9	-1.5	1.2
Pain all over the body in last month	1.3	1.4	3.7	0.1	-1.9	0.6
Worrier / anxious feelings	1.3	2.5	3.6	1.9	-0.5	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	5.6	0.6	2.4	-0.4
Leg fat percentage (right)	1.3	4.7	9.7	3.1	2.0	0.5
Leg fat mass (right)	1.3	4.9	11.3	3.4	1.8	0.7
Arm fat percentage (left)	1.3	5.1	12.2	3.5	1.5	0.8
Long-standing illness, disability or infirmity	1.3	1.9	4.0	0.7	-2.0	1.1
Medication: Gliclazide	1.3	1.4	3.2	0.0	1.0	-1.8
High blood pressure (mother)	1.2	1.7	3.9	0.6	2.0	-0.8
Arm fat percentage (right)	1.2	4.7	11.4	3.4	1.1	1.2
Lung cancer (father)	1.2	1.4	2.0	0.8	-1.3	1.4
Exposure to tobacco smoke outside home	1.2	1.6	2.5	0.2	-1.6	1.5
Worry too long after embarrassment	1.2	2.0	3.2	-1.8	1.5	-0.8
Whole body fat mass	1.2	4.9	11.9	3.5	1.4	0.9
Leg fat percentage (left)	1.2	4.2	8.0	2.8	2.1	0.7
Leg fat mass (left)	1.2	4.5	9.7	3.1	1.9	0.6
Ever had hysterectomy (womb removed)	1.1	1.2	2.5	-1.1	0.2	-1.6
Body mass index (BMI)	1.1	4.5	11.2	3.3	1.4	0.8
Trunk fat mass	1.1	4.6	11.0	3.3	1.4	0.9
Waist circumference	1.1	4.0	9.6	3.1	1.5	0.4
Medication: Cholesterol lowering	1.1	1.8	2.8	1.7	-0.5	1.5
Body fat percentage	1.1	4.5	10.0	3.2	1.6	0.9
Qualifications: nursing, teaching	1.1	1.7	2.6	0.3	-1.5	1.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.9	1.7	-0.7	0.6
Ever depressed for a whole week	1.1	1.4	3.0	0.2	-1.0	1.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.0	0.0	1.0	-1.7
Alcohol drinker status: Previous	1.1	1.2	2.1	-0.1	-1.2	1.4
Prostate Cancer	1.0	1.4	2.2	1.5	-1.2	0.7
Body Mass Index (BMI) (2010)	1.0	1.4	2.2	1.5	1.4	-0.5
Schizophrenia (2014)	1.0	2.2	4.4	0.0	-1.4	2.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.8	0.8	-0.9	1.3
Pack years adult smoking proportion	1.0	1.6	3.5	0.3	1.9	-1.1
Trunk fat percentage	1.0	4.0	9.0	3.0	1.4	1.0
Relative age voice broke	1.0	1.6	4.0	-2.0	0.8	0.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.1	-1.8	-0.0	-0.9
Number of full sisters	1.0	1.2	2.0	-0.0	-1.4	1.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.5	-0.3	-1.0	1.9
Basal cell carcinoma (self-reported)	1.0	1.2	1.9	0.3	-1.4	1.2
Ovarian Cancer	0.9	1.2	1.5	-1.2	-0.9	1.1
Bipolar Disorder (2011)	0.9	0.8	2.0	0.1	1.4	-0.7
Hearing difficulty/problems: Yes	0.9	1.3	2.2	1.5	0.5	1.2
Hand grip strength (right)	0.9	2.3	3.3	-1.8	1.1	-1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.1	0.9	-0.6	1.5
Heart attack	0.9	1.1	2.1	0.2	1.4	-1.1
Alcohol intake versus 10 years previously	0.9	1.3	2.5	-0.5	-1.0	1.6
Happiness	0.9	1.1	2.3	-1.5	-1.0	0.3
Birth weight of first child	0.9	1.6	2.3	1.3	-0.8	1.5
Glaucoma (self-reported)	0.9	1.0	1.9	-0.2	1.1	-1.4
Medication: Allopurinol	0.9	1.1	1.9	-1.2	-1.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.3	0.4	1.5	-1.0
Back pain experienced in last month	0.9	1.4	2.2	1.5	-0.8	1.2
Hearing aid user	0.9	1.0	1.3	1.0	1.1	0.8
Bipolar Disorder (2018)	0.8	1.3	3.2	-1.8	-0.5	-0.5
Bipolar Disorder or Schizophrenia	0.8	2.0	3.4	-0.4	-1.6	1.8
Respiratory disease	0.8	1.7	3.7	1.9	1.1	0.6
Severe depression (siblings)	0.8	0.9	1.5	-0.9	-1.2	0.5
Age when periods started (menarche)	0.8	1.9	3.1	-1.8	1.6	-0.3
Fluid intelligence score	0.8	1.6	4.4	-2.1	-0.1	-0.6
Hip circumference	0.8	3.3	8.0	2.8	1.3	0.6
Comparative body size at age 10	0.8	2.2	4.5	-0.9	1.2	-2.1
Number of children fathered	0.8	1.0	1.3	1.0	0.8	-1.2
Shortness of breath walking on level ground	0.8	0.9	1.5	0.1	1.1	-1.2
Medication: Omeprazole	0.8	1.0	2.0	-0.0	1.0	-1.4
Ever had bowel cancer screening	0.8	0.9	2.3	0.4	-1.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.1	-1.5	-0.5	0.1
Breast cancer (self-reported)	0.8	1.0	2.6	-0.3	1.6	-0.5
Osteoarthritis (self-reported)	0.8	1.0	1.3	0.9	1.1	-0.9
Medication: Bendroflumethiazide	0.8	1.3	2.5	1.6	1.0	0.5
Ever smoked	0.8	1.4	3.2	-1.8	-0.9	0.4
Unable to work because of sickness or disability	0.8	1.0	1.4	1.0	-1.2	0.8
Pack years of smoking	0.8	1.2	2.7	0.6	1.6	-0.8
BMI	0.7	4.1	10.5	3.2	1.3	0.3
Chronotype (morning person)	0.7	1.7	4.3	2.1	0.4	-0.7
Hearing difficulty/problems with background noise	0.7	1.2	2.0	1.4	0.9	0.8
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.0	1.4	-0.3	0.9
Weight	0.7	3.7	9.4	3.1	1.1	0.6
Mouth/teeth dental problems: Dentures	0.7	1.1	1.9	-0.8	0.9	-1.4
Prospective memory result	0.7	0.9	1.7	1.3	0.2	-0.9
Breastfed as a baby	0.7	0.8	1.8	-1.3	0.6	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.6	-0.0	1.3	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.9	1.4	-0.2	-0.8
Guilty feelings	0.7	1.0	1.9	0.6	-0.9	1.4
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.4	-0.8	0.7	-1.2
Average weekly beer plus cider intake	0.7	1.0	1.4	-0.9	1.2	-0.8
Cholesterol lowering medication	0.7	1.1	1.6	0.4	1.3	-1.2
Supplements: Calcium	0.7	0.8	2.1	-0.2	0.5	-1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.7	0.2	1.3	-1.0
Worry (Nagel 2018)	0.6	1.2	1.7	1.2	-0.7	1.3
Average weekly fortified wine intake	0.6	0.7	1.6	1.3	-0.6	0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	0.1	-1.4	0.3
Number of incorrect matches in round	0.6	1.0	2.0	-0.0	-0.9	1.4
Past tobacco smoking	0.6	1.0	1.5	1.2	0.6	-1.1
Forced vital capacity (FVC)	0.6	2.5	4.6	-2.1	0.9	-1.4
Allergy	0.6	1.3	2.5	-1.1	-1.6	0.5
Noisy workplace	0.6	0.7	1.6	1.3	0.8	-0.0
Length of working week for main job	0.6	0.7	1.8	0.1	0.5	-1.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	-1.1	-0.2	-1.3
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.2	0.2	1.1	-0.9
Alcohol intake frequency.	0.6	1.3	2.2	0.0	-1.3	1.5
Illnesses of father: Heart disease	0.6	0.8	1.8	0.8	0.3	-1.3
Illnesses of siblings: Diabetes	0.6	0.7	1.6	1.2	-0.1	0.8
Smoking status: Previous	0.6	1.0	2.7	0.1	-0.5	1.6
Osteoporosis (self-reported)	0.6	0.8	1.5	-0.8	-1.2	-0.4
Illnesses of father: None of the above (group 1)	0.6	0.8	2.4	-1.5	-0.1	0.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	-0.1	0.7	-1.3
Medication: Lisinopril	0.6	0.8	2.5	0.1	1.6	-0.2
Number of operations (self-reported)	0.6	0.8	2.1	-0.1	0.6	-1.4
Age at First Birth	0.5	0.7	1.8	0.0	-1.4	0.6
HDL Cholesterol	0.5	0.8	1.2	1.1	-0.5	1.0
Neuroticism (2016)	0.5	0.8	2.3	-0.2	1.5	0.1
Triglycerides	0.5	0.8	2.2	1.5	0.3	-0.4
Number of treatments/medications taken	0.5	0.9	2.1	1.4	-0.7	0.3
Angina	0.5	0.6	1.1	0.4	-1.0	0.8
Medication for hormone replacement therapy	0.5	0.6	1.4	-0.1	-1.2	0.5
Maternal smoking around birth	0.5	0.8	1.4	-0.7	0.6	-1.2
Had other major operations	0.5	0.6	1.3	0.1	0.8	-1.1
Qualifications: None of the above	0.5	1.1	2.1	1.4	1.1	-0.2
Medication: Ramipril	0.5	0.7	1.2	1.1	0.9	0.2
Neuroticism score	0.5	1.0	1.9	1.0	0.1	1.4
Hair/balding pattern: Pattern 3	0.5	0.8	1.9	-1.4	-0.7	-0.0
Number of live births	0.5	0.7	1.5	-0.8	-1.2	0.2
Asthma	0.5	0.9	1.6	1.3	1.0	-0.4
Headache pain in last month	0.5	0.9	1.4	-1.2	1.1	0.0
Medication: Amlodipine	0.5	0.7	1.0	0.5	-0.8	1.0
Age at first live birth	0.5	0.9	1.7	1.3	-0.2	1.0
Leg pain on walking	0.5	0.7	1.2	1.1	0.0	0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	1.1	-0.4	0.5
Hypertension (Self-reported)	0.5	1.3	3.4	0.7	1.8	0.1
Loneliness, isolation	0.5	0.7	0.9	1.0	0.8	-0.7
Asthma (self-reported)	0.5	1.1	2.2	1.5	1.0	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	-0.6	-1.2	0.2
Ulcerative Colitis (UC)	0.4	0.8	2.0	-1.4	-0.5	-0.4
LDL Cholesterol	0.4	0.6	1.1	-0.5	0.6	-1.1
Lung FEV1/FVC ratio	0.4	1.9	4.9	-0.0	-2.2	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.2	-1.1	-0.7	0.1
Medication: Metformin	0.4	0.5	0.8	0.1	0.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	0.1	1.1	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.8	-0.9	-0.8	0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	0.4	-0.7	0.8
Qualifications: CSEs or equivalent	0.4	0.6	1.4	0.5	-1.2	0.2
High blood pressure	0.4	1.1	1.9	1.1	1.4	0.4
Medication: Atenolol	0.4	0.4	0.8	0.9	0.5	0.5
Medication: Levothyroxine sodium	0.4	0.6	0.9	0.5	-0.8	1.0
Impedance of arm (right)	0.4	1.6	4.0	-2.0	-1.0	-0.2
Time employed in main current job	0.4	0.5	0.7	-0.4	0.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	-0.7	0.2	-0.9
Medication: Lansoprazole	0.4	0.5	0.8	-0.7	-0.2	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	0.1	0.4	1.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.1	-0.3	-0.6	1.1
High blood pressure (siblings)	0.4	0.6	1.8	-0.0	1.3	0.1
Neck or shoulder pain in last month	0.4	0.6	1.3	0.8	-0.1	1.1
Angina (self-reported)	0.4	0.5	1.2	0.3	-1.1	0.4
Migraine (self-reported)	0.4	0.5	1.0	-1.0	0.6	-0.3
Mean time to correctly identify matches	0.4	0.7	2.0	0.0	-0.1	1.4
Had major operations	0.4	0.4	0.9	0.5	0.4	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	1.2	0.2	0.3
Ever taken oral contraceptive pill	0.4	0.5	0.6	0.8	-0.5	0.8
High cholesterol (Self-reported)	0.4	0.7	1.1	0.8	1.1	-0.5
Alcohol drinker status: Never	0.4	0.5	1.1	0.6	0.1	-1.0
Basal metabolic rate	0.4	2.0	5.3	2.3	0.8	0.3
Arm fat-free mass (left)	0.4	2.0	5.2	2.3	0.7	0.6
Irritability	0.4	0.7	0.9	0.9	0.5	0.9
Vascular/heart problems diagnosed by doctor	0.4	1.2	1.5	-1.2	-1.1	-0.9
Arm predicted mass (left)	0.4	1.9	4.8	2.2	0.8	0.5
Depressed Affect (Nagel 2018)	0.3	0.5	1.1	0.7	1.1	-0.1
Major Depression (MDD)	0.3	0.4	1.1	-0.4	1.0	0.1
Allergy or Eczema	0.3	0.7	1.3	0.9	0.0	1.1
Cardiovascular Disease	0.3	1.0	2.0	1.4	0.6	0.8
Neuroticism	0.3	0.6	0.9	0.9	1.0	0.2
Relative age of first facial hair	0.3	0.7	1.4	-0.8	1.2	-0.1
Vitamin and mineral supplements	0.3	0.4	0.7	-0.5	0.8	-0.5
Leg fat-free mass (left)	0.3	1.6	4.0	2.0	0.8	0.2
Townsend deprivation index at recruitment	0.3	0.5	0.9	0.7	0.9	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.4	1.2	0.9	-0.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.4	0.8	0.5
Impedance of leg (left)	0.3	1.7	4.7	-2.2	0.0	-0.5
Leg predicted mass (left)	0.3	1.5	4.1	2.0	0.6	0.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	-0.5	0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.0	-1.4	0.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.2	-1.1	-0.2	-0.1
Impedance of arm (left)	0.3	1.2	2.8	-1.7	-0.4	-0.8
Medication: Paracetamol	0.3	0.5	0.5	0.7	0.6	0.7
Gout (self-reported)	0.3	0.4	0.6	-0.7	-0.8	-0.2
Forced vital capacity (FVC), Best measure	0.3	0.9	2.2	-1.5	0.8	-0.2
Arm fat-free mass (right)	0.3	1.5	3.4	1.8	1.0	-0.0
Medication for pain relief, constipation, heartburn	0.3	0.4	0.8	-0.9	-0.4	-0.5
Medication: Blood pressure	0.3	0.5	1.3	0.1	0.4	1.2
Arm predicted mass (right)	0.3	1.5	3.4	1.9	1.0	0.1
Average weekly red wine intake	0.3	0.4	0.7	-0.3	-0.6	0.8
Mood swings	0.3	0.6	0.9	1.0	0.4	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	0.4	1.0	-0.4
Medication: Atorvastatin	0.3	0.4	0.6	0.8	0.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.9	-0.6	0.2
Impedance of whole body	0.3	1.4	3.7	-1.9	-0.5	-0.3
Depression (Nagel 2018)	0.2	0.3	0.5	0.7	0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	-1.1	-0.9	0.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.8	-0.3	0.5
Rheumatoid Arthritis	0.2	0.3	0.7	0.5	-0.0	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.6	0.2	0.5
Impedance of leg (right)	0.2	0.7	2.0	-1.4	-0.2	-0.4
Serious illness, injury or assault to yourself	0.2	0.3	0.6	-0.8	0.1	-0.4
Alcohol usually taken with meals	0.2	0.4	0.9	-1.0	-0.4	-0.1
Had menopause	0.2	0.2	0.4	0.1	-0.6	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.9	0.1	0.4
Trunk fat-free mass	0.2	1.1	3.0	1.7	0.6	0.0
Depression (self-reported)	0.2	0.2	0.6	0.4	-0.0	0.7
Illnesses of mother	0.2	0.2	0.4	-0.6	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.7	-1.3	-0.3	0.1
Trunk predicted mass	0.2	1.2	3.1	1.8	0.6	0.1
Tense / ‘highly strung’	0.2	0.4	0.6	0.7	-0.3	0.8
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	1.1	0.1	-0.2
Peak expiratory flow (PEF)	0.2	0.5	1.4	-0.4	-0.2	-1.2
Pulse wave reflection index	0.2	0.3	0.5	-0.6	-0.7	0.1
Birth weight	0.2	0.4	1.0	0.2	-1.0	0.0
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.1	0.5	0.6
Medication: Ibuprofen	0.2	0.3	0.8	-0.9	0.2	-0.1
Comparative height size at age 10	0.2	1.2	2.5	1.0	-1.6	0.2
Medication: Aspirin	0.2	0.2	0.4	0.6	0.1	0.6
Knee pain experienced in last month	0.2	0.4	0.8	0.5	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.5	0.7	0.0	0.7
Whole body fat-free mass	0.2	1.3	3.2	1.8	0.7	0.1
Leg fat-free mass (right)	0.2	1.1	2.9	1.7	0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.6	-0.5	-0.3
Medication: Aspirin	0.2	0.2	0.4	0.4	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	-0.4	1.1	0.1
Whole body water mass	0.2	1.2	3.1	1.8	0.8	0.1
Leg predicted mass (right)	0.2	1.1	2.9	1.7	0.6	0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.0	-1.0	-0.1
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.6	0.4	-0.5
Medication: Blood pressure	0.2	0.4	0.5	0.7	0.7	-0.2
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.9	0.2	0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.7	0.4	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.2	-0.4	-0.1
Reaction Time	0.1	0.3	0.5	-0.7	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.7	0.2	-0.3
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.4	0.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.5	0.0	-0.7	0.0
Ulcerative Colitis	0.1	0.1	0.2	-0.1	-0.4	-0.5
Heel T-Score	0.1	0.6	0.8	-0.8	0.5	0.9
Height	0.1	2.1	5.5	-0.7	0.6	-2.4
Waist Hip Ratio (WHR)	0.1	0.4	0.8	0.9	0.5	-0.2
Hypothyroidism (self reported)	0.1	0.3	0.8	-0.0	0.9	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.2	-0.4	-0.3
Lung FVC	0.1	0.6	1.8	-1.3	0.0	-0.2
Tanning	0.1	1.7	2.0	-1.4	1.1	-1.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.1	-0.1	-0.4
Diabetes (mother)	0.1	0.1	0.2	0.1	-0.4	-0.2
Fed-up feelings	0.1	0.2	0.4	-0.3	0.4	0.6
Taking other prescription medications	0.1	0.2	0.5	0.7	-0.2	-0.3
Multivitamins +/- minerals	0.1	0.2	0.3	0.5	-0.4	0.4
Nervous feelings	0.1	0.3	0.7	0.2	-0.8	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.2	0.4	-0.6
Diabetes (self-reported)	0.1	0.2	0.3	-0.5	-0.3	-0.5
Medication: Simvastatin	0.1	0.2	0.4	0.4	0.6	-0.1
Illnesses of siblings	0.1	0.1	0.3	-0.0	0.1	-0.5
Father’s age at death	0.1	0.1	0.1	0.3	0.1	-0.4
Pulse rate	0.1	0.2	0.5	0.4	-0.1	0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.4	-0.2	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.4	-0.6	-0.0	0.1
Blood clot in the leg (DVT)	0.1	0.2	0.3	-0.4	-0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.6	0.2	0.7
Number of full brothers	0.1	0.1	0.2	-0.2	0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	-0.5	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.8	-0.1	0.2
Pulse wave peak to peak time	0.1	0.2	0.3	-0.3	0.3	0.5
Health satisfaction	0.1	0.1	0.3	-0.2	0.1	0.6
Qualifications: College or University degree	0.1	0.3	0.7	-0.8	-0.3	0.2
Overall health rating	0.1	0.3	0.6	0.8	0.2	-0.4
Age at last live birth	0.1	0.2	0.5	0.3	0.0	0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	0.5	-0.5	0.2
Supplements: Vitamin C	0.1	0.1	0.3	0.5	-0.0	0.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	0.1	-0.7
Eye problems/disorders: Cataract	0.1	0.1	0.4	0.0	0.1	-0.6
Medication for cholesterol	0.1	0.1	0.2	-0.5	-0.4	0.2
Mineral and other dietary supplements	0.1	0.2	0.4	0.2	0.6	0.2
Miserableness	0.1	0.1	0.2	0.0	0.4	0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.2	-0.1	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.5	-0.1	-0.4
Medication: Paracetamol	0.1	0.1	0.3	0.5	0.3	0.1
Risk taking	0.1	0.1	0.2	-0.4	-0.4	-0.1
Pain experienced in last month	0.1	0.2	0.4	0.6	0.3	-0.2
Heart disease (siblings)	0.1	0.2	0.5	-0.2	-0.7	-0.0
Breast Cancer	0.0	0.1	0.2	0.5	0.1	0.3
Lupus	0.0	0.1	0.1	-0.3	-0.1	-0.4
Blood Platelet Count	0.0	0.5	1.3	-0.1	1.1	0.2
Blood White Count	0.0	0.2	0.3	-0.2	-0.5	0.6
Hair Pigment	0.0	0.5	1.5	0.1	1.2	0.1
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.0	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.0	0.3	-0.1
Supplements: Glucosamine	0.0	0.0	0.1	-0.2	0.2	0.0
Sitting height	0.0	0.1	0.2	0.5	-0.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	-0.4	0.3	0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.2	-0.5	0.1
Standing height	0.0	0.1	0.3	-0.1	-0.5	-0.3
Pulse rate, automated reading	0.0	0.1	0.2	0.5	0.0	0.1
Chest pain or discomfort	0.0	0.0	0.0	0.1	-0.1	0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.2	-0.0	0.1	0.4
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.1	0.3	-0.2

Hub : Genes

SP140

Models

Trait associations