Hub : Genes

SPAG1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0460 0.0160 1.4e-04 0.034 0.038 0.033 0.037 0.029 4.7e-05 1.9e-05 5.4e-05 2.3e-05 1.8e-04
2 GTEx Adipose Subcutaneous 0.1150 0.0300 1.6e-08 0.146 NA 0.162 NA 0.160 5.2e-12 NA 3.4e-13 NA 5.1e-13
3 GTEx Adipose Visceral Omentum 0.2660 0.0600 4.2e-10 0.296 NA 0.291 NA 0.292 8.3e-16 NA 1.6e-15 NA 1.4e-15
4 GTEx Brain Cerebellum 0.3060 0.0910 6.9e-05 0.115 NA 0.091 NA 0.063 2.9e-04 NA 1.2e-03 NA 6.3e-03
5 GTEx Breast Mammary Tissue 0.1390 0.0570 1.7e-03 0.030 NA -0.002 NA 0.029 1.1e-02 NA 4.3e-01 NA 1.2e-02
6 GTEx Breast Mammary Tissue (Female) 0.2404 0.0907 2.1e-03 -0.008 NA -0.010 NA -0.010 6.5e-01 NA 1.0e+00 NA 8.9e-01
7 GTEx Cells Transformed fibroblasts 0.2960 0.0600 1.9e-13 0.250 NA 0.200 NA 0.239 8.4e-19 NA 5.5e-15 NA 6.3e-18
8 GTEx Lung 0.0684 0.0274 1.7e-03 0.070 NA 0.024 NA 0.048 4.5e-06 NA 5.9e-03 NA 1.5e-04
9 GTEx Muscle Skeletal 0.0858 0.0279 1.2e-05 0.075 NA 0.095 NA 0.091 7.7e-08 NA 1.3e-09 NA 2.9e-09
10 GTEx Nerve Tibial 0.1216 0.0352 1.4e-06 0.113 NA 0.147 NA 0.152 2.3e-08 NA 1.4e-10 NA 6.2e-11
11 GTEx Skin Sun Exposed Lower leg 0.0760 0.0320 1.4e-03 0.019 NA 0.000 NA 0.003 9.1e-03 NA 3.2e-01 NA 1.7e-01
12 GTEx Testis 0.1510 0.0570 7.8e-04 0.068 NA 0.095 NA 0.094 5.7e-04 NA 5.2e-05 NA 5.7e-05
13 GTEx Thyroid 0.2290 0.0510 7.6e-13 0.219 NA 0.243 NA 0.216 1.1e-16 NA 1.3e-18 NA 1.7e-16
14 GTEx Whole Blood 0.1220 0.0330 3.9e-08 0.119 NA 0.150 NA 0.147 4.2e-11 NA 1.0e-13 NA 1.8e-13
15 METSIM Adipose 0.0579 0.0177 2.6e-08 0.078 0.057 0.058 0.061 0.070 9.1e-12 6.0e-09 5.0e-09 1.6e-09 1.1e-10
16 YFS Blood 0.1763 0.0283 0.0e+00 0.251 0.285 0.298 0.299 0.299 2.0e-81 2.7e-94 4.1e-99 8.6e-100 9.6e-100
17 TCGA Kidney Renal Clear Cell Carcinoma 0.0586 0.0316 9.6e-07 0.055 0.049 0.053 NA 0.054 7.8e-07 3.1e-06 1.3e-06 NA 1.0e-06
18 TCGA Brain Lower Grade Glioma 0.0286 0.0199 2.4e-03 0.022 0.008 0.005 NA 0.009 1.3e-03 3.9e-02 7.7e-02 NA 3.1e-02
19 TCGA Soft Tissue Sarcoma 0.0700 0.0670 9.8e-03 0.028 0.019 0.027 NA 0.035 8.1e-03 2.5e-02 9.5e-03 NA 3.5e-03
20 TCGA Thyroid Carcinoma 0.0520 0.0320 1.1e-05 0.054 0.055 0.060 NA 0.058 5.4e-06 4.8e-06 1.6e-06 NA 2.5e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bipolar Disorder (2018) 0.1 0.2 0.8 0.7 -0.4 -0.2 0.2 -0.3 0.2 -0.4 -0.1 -0.3 -0.4 -0.4 0.1 -0.6 -0.1 -0.4 -0.3 -0.4 -0.2 -0.3 -0.9
Bipolar Disorder or Schizophrenia 0.1 0.2 0.8 0.7 -0.2 0.0 0.7 -0.3 -0.9 -0.2 0.2 -0.3 -0.5 -0.2 -0.4 -0.4 -0.0 -0.5 -0.3 -0.3 -0.0 -0.1 -0.8
Depressed Affect (Nagel 2018) 0.0 0.1 0.6 0.4 0.2 0.3 0.6 -0.1 0.4 0.1 0.3 -0.0 -0.1 0.3 -0.8 -0.2 -0.1 -0.2 -0.0 0.2 0.4 -0.3 -0.2
Depression (Nagel 2018) 0.3 0.4 1.4 0.5 0.7 0.8 0.9 0.1 0.8 0.7 0.9 0.5 0.4 0.9 -1.2 0.6 0.5 0.0 0.3 0.7 0.9 0.5 0.2
Intelligence (Savage-Jansen 2018) 0.4 1.2 6.5 -1.2 1.0 0.8 -0.3 1.0 2.6 0.9 0.8 1.0 1.0 0.9 -0.2 0.5 1.1 1.2 1.0 1.0 0.9 1.3 0.9
Neuroticism (Nagel 2018) 0.3 0.7 2.0 0.6 -0.9 -0.8 0.1 -0.7 -0.1 -1.1 -0.9 -0.9 -0.8 -0.9 0.4 -1.4 -1.0 -0.6 -0.8 -0.9 -0.8 -1.2 -0.8
Schizophrenia (2018) 0.1 0.2 1.7 0.4 0.0 0.2 0.7 -0.1 -1.3 -0.0 0.4 -0.1 -0.4 0.1 -0.6 0.0 0.1 -0.3 -0.1 -0.0 0.2 0.1 -0.3
Schizophrenia vs Biploar Disorder 1.6 2.1 3.6 -0.2 1.5 1.4 1.4 1.0 -1.8 1.7 1.6 1.4 1.1 1.7 -1.7 1.7 1.4 0.5 0.9 1.4 1.6 1.7 1.9
Worry (Nagel 2018) 1.1 2.3 5.0 1.0 -1.7 -1.6 0.1 -1.5 -0.8 -1.9 -1.7 -1.6 -1.5 -1.7 1.0 -2.2 -1.6 -1.2 -1.7 -1.7 -1.6 -1.7 -1.1
Alzheimer’s Disease (in mother) 0.1 0.1 0.9 0.1 -0.1 -0.1 -0.8 0.1 -1.0 -0.3 -0.1 -0.1 0.1 -0.3 0.4 -0.2 -0.0 0.2 0.2 -0.2 -0.2 0.3 -0.1
Alzheimer’s Disease (in father) 3.9 4.2 6.6 0.4 -2.4 -2.4 -1.0 -2.0 -0.1 -2.2 -2.4 -2.2 -2.1 -2.5 2.2 -2.3 -2.1 -1.3 -1.9 -2.4 -2.6 -2.0 -2.3
Alzheimer’s Disease (including proxy) 0.6 0.8 1.7 -0.0 -1.0 -1.0 -1.3 -0.7 -0.3 -1.0 -1.0 -0.9 -0.8 -1.2 1.2 -0.9 -0.7 -0.3 -0.3 -1.1 -1.2 -0.5 -1.0
Crohns Disease (2017) 0.2 0.5 1.0 -0.1 0.7 0.5 -0.4 0.8 0.4 0.7 0.5 0.7 0.8 0.6 -0.1 0.7 0.7 0.9 1.0 0.8 0.5 1.0 0.6
Irritable Bowel Disease (IBD) 0.5 1.2 2.4 -1.3 1.1 0.9 0.1 1.2 0.3 1.2 0.9 1.1 1.1 1.1 -0.8 1.4 1.1 0.9 1.5 1.2 1.1 1.5 1.2
Ulcerative Colitis (UC) 0.6 1.1 2.1 -1.4 1.1 0.9 0.7 0.9 0.1 1.3 0.8 1.1 0.9 1.2 -1.1 1.5 1.0 0.5 1.2 1.0 1.1 1.3 1.1
Major Depression (MDD) 0.0 0.0 0.1 0.2 -0.1 -0.0 0.0 -0.1 -0.1 -0.3 -0.1 -0.1 -0.2 -0.1 -0.0 -0.3 -0.2 -0.2 -0.1 -0.1 -0.0 -0.3 0.2
Reaction Time 0.4 0.8 2.6 1.6 -0.1 -0.0 1.6 -1.1 -1.6 0.0 0.2 -0.5 -0.8 0.3 -1.2 0.1 -0.3 -1.6 -0.9 -0.2 0.3 -0.1 -0.1
Verbal and Numeric Reasoning (VNR) 0.8 2.0 6.7 -0.6 1.5 1.5 0.1 1.3 2.6 1.5 1.4 1.4 1.4 1.5 -0.9 1.2 1.4 1.2 1.2 1.5 1.4 1.7 1.3
Breast Cancer 1.6 4.0 10.1 -3.2 1.5 1.2 -2.6 2.8 0.1 0.9 0.9 2.0 2.5 1.0 1.0 1.4 2.0 3.2 2.6 1.7 1.0 1.8 2.7
Ovarian Cancer 1.3 1.8 4.1 -1.6 1.1 0.9 -1.5 1.6 2.0 0.8 0.7 1.4 1.7 0.8 0.3 1.1 1.2 1.9 1.8 1.2 0.8 1.4 1.4
Prostate Cancer 0.0 0.0 0.5 0.4 0.0 0.1 0.1 0.2 -0.7 -0.0 0.1 0.0 -0.0 -0.0 0.0 0.4 0.2 0.0 -0.1 -0.1 0.1 -0.3 0.0
Age at First Birth 0.5 0.8 1.4 0.7 1.0 1.0 -0.0 0.7 1.1 1.0 1.0 0.9 0.9 1.0 -0.8 1.2 0.9 0.6 0.4 1.0 1.0 1.0 0.7
Bipolar Disorder (2011) 0.2 0.2 0.4 -0.3 0.5 0.6 -0.3 0.5 0.2 0.4 0.5 0.4 0.5 0.5 -0.1 0.6 0.6 0.6 0.6 0.6 0.6 0.4 0.5
Body Mass Index (BMI) (2010) 0.1 0.2 1.2 0.2 0.0 0.1 1.1 -0.2 -0.8 0.1 0.2 -0.1 -0.3 0.1 -0.8 0.0 -0.3 -0.7 -0.2 -0.1 0.2 -0.1 -0.2
Coronary Artery Disease (CAD) 0.2 0.2 1.2 0.7 0.1 0.0 1.1 -0.4 -0.4 0.3 0.1 0.1 -0.3 0.3 -0.8 0.4 -0.1 -0.5 -0.7 0.1 0.3 0.8 -0.1
Crohns Disease (2012) 0.2 0.3 0.7 0.4 -0.6 -0.6 -0.3 -0.3 0.4 -0.6 -0.5 -0.5 -0.5 -0.7 0.8 -0.7 -0.4 -0.1 -0.7 -0.5 -0.7 -0.3 -0.9
Mean Putamen Volume 1.2 1.4 2.1 -0.6 1.4 1.4 0.7 1.1 0.6 1.4 1.4 1.2 1.2 1.4 -1.2 1.1 1.2 0.7 1.0 1.3 1.4 1.2 1.0
Fasting Glucose 0.9 1.1 2.8 0.2 -0.8 -0.6 1.7 -1.4 -0.8 -0.6 -0.4 -1.1 -1.4 -0.5 -0.6 -0.8 -1.0 -1.6 -1.3 -1.0 -0.4 -1.6 -1.1
HbA1C 0.3 0.3 1.3 0.6 0.6 0.6 1.0 0.3 -0.4 0.3 0.7 0.3 0.2 0.8 -1.1 0.1 0.4 -0.2 0.3 0.6 0.9 0.1 0.4
HDL Cholesterol 0.6 1.0 2.0 -0.3 1.2 1.2 0.9 0.9 0.5 1.0 1.2 0.9 0.9 1.3 -1.4 1.0 1.0 0.5 0.5 1.2 1.3 0.6 1.2
LDL Cholesterol 0.2 0.3 0.8 0.9 0.4 0.6 0.2 0.2 -0.3 0.6 0.7 0.5 0.2 0.6 -0.8 0.7 0.5 -0.4 0.6 0.4 0.5 0.5 0.9
Lupus 1.0 1.5 3.4 -1.7 1.2 1.0 -0.6 1.7 -0.7 0.8 0.7 1.3 1.5 1.0 0.1 0.9 1.4 1.7 1.6 1.2 0.9 1.2 1.8
Neuroticism (2016) 0.4 0.6 2.8 -0.1 -0.5 -0.5 -1.7 0.0 0.6 -0.8 -0.7 -0.3 -0.2 -0.8 1.4 -1.0 -0.4 0.6 0.3 -0.5 -0.9 -1.0 -0.3
Primary Biliary Cirrhosis 0.0 0.0 0.2 -0.2 0.1 0.0 0.2 0.2 0.1 0.0 0.0 0.1 0.1 0.0 0.0 -0.4 0.2 0.2 0.3 0.0 0.1 0.5 0.2
Rheumatoid Arthritis 0.5 0.7 2.4 -1.3 0.7 0.8 -0.8 1.1 0.5 0.7 0.6 0.8 0.9 0.5 -0.2 1.0 0.9 1.0 1.6 0.6 0.5 0.8 0.9
Schizophrenia (2014) 0.1 0.2 2.6 0.5 0.1 0.3 0.9 0.0 -1.6 0.0 0.4 0.0 -0.2 0.1 -0.6 -0.1 0.3 -0.3 -0.1 -0.0 0.2 0.5 0.1
Triglycerides 2.0 3.2 6.6 1.1 -1.9 -1.9 0.9 -2.3 -0.4 -1.8 -1.7 -2.0 -2.1 -1.7 0.6 -1.7 -1.8 -2.3 -1.9 -2.0 -1.6 -2.6 -1.8
Type 2 Diabetes (T2D) (2012) 2.0 2.3 5.6 1.1 -1.6 -1.5 0.5 -1.6 -1.5 -1.5 -1.5 -1.6 -1.9 -1.6 0.8 -1.0 -1.7 -1.4 -2.0 -1.7 -1.0 -2.4 -1.3
Ulcerative Colitis 0.2 0.3 1.7 0.1 -0.0 -0.1 1.3 -0.4 -1.3 0.2 -0.0 -0.2 -0.5 0.2 -0.9 0.4 -0.2 -0.9 -0.5 -0.2 0.2 0.1 0.0
Blood Eosinophil Count 0.0 0.1 1.1 -0.8 0.1 0.1 -0.4 0.4 1.0 0.1 0.1 0.2 0.1 -0.1 0.2 0.3 -0.0 0.5 0.5 -0.1 -0.1 0.1 -0.2
Blood Platelet Count 0.1 0.9 2.7 1.6 -0.5 -0.5 1.6 -1.2 -1.0 -0.1 -0.3 -0.8 -1.0 0.0 -0.9 -0.1 -0.9 -1.6 -1.2 -0.5 -0.1 -0.6 -1.1
Blood Red Count 1.1 10.3 18.7 4.3 -3.5 -3.6 -2.1 -3.1 -2.5 -3.6 -3.6 -3.3 -2.8 -3.6 3.3 -3.6 -3.2 -2.2 -2.8 -3.4 -3.6 -2.4 -2.9
Blood White Count 0.2 1.3 8.4 1.4 0.5 0.8 2.9 -0.4 -0.9 1.0 1.1 0.0 -0.6 1.0 -2.3 0.8 -0.0 -1.6 -0.7 0.3 1.1 -0.2 -0.6
Heel T-Score 0.4 3.1 18.1 -1.9 1.2 1.1 -1.6 1.7 4.3 1.3 0.9 1.6 1.8 1.1 0.1 2.1 1.3 1.7 2.0 1.4 1.0 1.3 2.3
BMI 0.5 3.0 5.5 -1.7 1.8 1.9 0.2 1.7 2.3 1.7 1.9 1.8 1.5 1.7 -1.5 2.1 1.8 1.2 2.0 1.7 1.9 1.7 1.5
Height 0.3 6.3 16.9 -4.1 2.2 1.9 -2.0 3.3 1.1 1.7 1.6 2.7 3.2 1.6 0.6 1.4 2.7 3.7 2.7 2.3 1.6 2.9 3.6
Waist Hip Ratio (WHR) 1.2 5.4 11.9 1.6 -2.4 -2.3 0.7 -2.7 -1.8 -2.1 -2.2 -2.6 -2.8 -2.1 1.0 -2.0 -2.7 -2.5 -2.5 -2.5 -2.2 -3.4 -2.6
Systolic Blood Pressure 0.5 2.4 4.3 1.7 -1.6 -1.4 0.5 -2.0 -0.3 -1.3 -1.3 -1.8 -2.0 -1.3 0.3 -1.2 -1.9 -1.9 -1.5 -1.6 -1.2 -2.1 -2.0
Smoking Status 0.1 0.3 1.2 0.1 -0.6 -0.3 -0.3 -0.4 0.7 -0.4 -0.3 -0.4 -0.6 -0.8 0.3 -0.1 -0.4 -0.1 -0.3 -0.7 -0.6 -0.7 -1.1
Allergy or Eczema 0.7 1.9 5.1 -2.3 1.2 1.0 -1.0 1.8 1.0 0.9 0.8 1.3 1.6 1.0 -0.1 1.1 1.3 1.5 2.0 1.2 0.9 2.0 1.7
Cardiovascular Disease 0.1 0.5 2.3 0.3 -0.4 -0.1 1.5 -0.8 -0.8 -0.2 0.1 -0.6 -1.0 -0.2 -0.9 0.1 -0.6 -1.2 -0.7 -0.5 -0.1 -0.6 -0.8
Hypothyroidism (self reported) 3.5 8.0 15.9 -3.6 2.6 2.5 -1.5 3.3 4.0 2.5 2.3 3.1 3.2 2.0 -0.3 2.5 3.0 3.8 3.6 2.6 2.1 2.9 2.8
Respiratory disease 1.8 3.9 7.4 0.9 -2.2 -2.2 -2.0 -1.3 -1.0 -2.6 -2.3 -1.8 -1.4 -2.7 2.6 -2.3 -2.0 -0.6 -1.4 -2.3 -2.6 -1.9 -1.4
Type 2 Diabetes (T2D) (2018) 0.4 0.7 3.0 0.1 -0.7 -0.6 1.0 -0.6 -1.7 -0.6 -0.4 -0.9 -1.0 -0.7 -0.1 -0.5 -1.0 -0.9 -0.9 -0.8 -0.6 -0.9 -1.0
Lung FEV1/FVC ratio 3.0 15.0 27.8 -2.0 4.4 4.6 3.8 2.9 1.7 4.9 5.0 3.9 2.9 4.7 -5.3 4.5 4.0 1.3 2.1 4.1 4.8 3.9 3.2
Lung FVC 0.3 1.4 2.2 1.0 -1.3 -1.2 0.6 -1.4 -0.9 -1.3 -1.2 -1.4 -1.4 -1.1 0.5 -1.0 -1.2 -1.4 -1.5 -1.3 -1.2 -1.3 -1.1
Neuroticism 0.0 0.1 0.5 -0.1 -0.0 0.0 0.5 -0.1 -0.0 -0.1 0.0 -0.2 -0.2 0.1 -0.4 -0.7 -0.3 -0.3 -0.1 -0.0 0.1 -0.4 -0.2
Chronotype (morning person) 0.2 0.4 1.2 1.1 -0.3 -0.2 1.0 -0.6 -0.3 -0.1 -0.0 -0.5 -0.8 -0.1 -0.6 -0.4 -0.5 -1.0 -0.9 -0.3 -0.1 -0.7 -0.4
Hair Pigment 0.4 11.3 18.5 2.0 -3.7 -3.8 -1.5 -2.8 -2.4 -4.0 -3.9 -3.6 -3.0 -3.8 3.6 -4.3 -3.3 -1.9 -2.7 -3.5 -3.9 -4.3 -3.1
Tanning 0.2 2.5 7.2 0.6 1.6 1.8 2.3 0.5 0.2 1.9 2.0 1.2 0.8 2.1 -2.7 1.9 1.4 -0.2 0.8 1.6 2.1 1.5 0.9
Hand grip strength (left) 1.1 3.0 6.3 -2.5 1.6 1.3 -1.4 2.4 0.7 1.3 1.0 1.8 2.4 1.2 0.4 1.3 1.8 2.5 2.0 1.7 1.1 1.6 2.2
Number of treatments/medications taken 0.8 1.4 3.8 -0.7 1.2 1.4 1.6 0.6 0.7 1.3 1.6 0.9 0.4 1.3 -1.9 1.8 1.0 0.2 0.9 1.0 1.5 0.5 0.6
Average weekly spirits intake 0.1 0.2 1.3 -0.4 0.3 0.3 1.1 0.1 -0.4 0.5 0.4 0.2 -0.1 0.4 -0.7 0.5 0.1 -0.2 -0.2 0.1 0.4 0.1 0.1
Sensitivity / hurt feelings 1.4 2.4 3.9 1.3 -1.7 -1.9 -0.5 -1.6 -0.4 -1.6 -2.0 -1.5 -1.4 -1.7 1.5 -1.9 -1.7 -1.3 -1.7 -1.6 -1.8 -1.3 -1.3
Frequency of depressed mood in last 2 weeks 0.2 0.2 3.8 0.7 0.1 0.1 -0.3 -0.1 1.9 0.2 0.1 0.3 0.2 0.1 0.1 0.2 -0.0 0.3 0.3 0.1 0.1 0.0 -0.1
Hearing difficulty/problems: Yes 0.2 0.3 3.2 -0.3 -0.3 -0.4 -0.6 -0.2 1.8 -0.3 -0.4 -0.3 -0.2 -0.4 0.7 -0.3 -0.1 0.0 -0.3 -0.2 -0.4 -0.6 -1.0
Relative age of first facial hair 0.2 0.3 0.7 -0.2 0.6 0.6 0.0 0.6 0.3 0.4 0.6 0.7 0.6 0.4 -0.4 0.7 0.7 0.6 0.6 0.5 0.6 0.7 0.8
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 -0.1 -0.6 -0.6 -0.2 -0.4 0.7 -0.5 -0.6 -0.6 -0.5 -0.6 0.7 -0.6 -0.3 -0.3 -0.1 -0.5 -0.5 -0.5 -0.8
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.7 -1.3 0.1 -0.1 -0.9 0.4 -0.5 -0.0 -0.2 0.2 0.4 -0.1 0.4 -0.0 0.2 0.5 0.6 0.0 -0.0 0.2 0.8
Ever had hysterectomy (womb removed) 1.3 1.5 4.5 1.7 -1.0 -1.0 1.2 -1.6 -2.1 -0.9 -0.9 -1.3 -1.4 -0.6 -0.1 -1.6 -1.2 -1.8 -1.3 -0.9 -0.7 -0.8 -0.8
Systolic blood pressure, automated reading 0.1 0.3 1.0 0.1 -0.5 -0.4 -0.0 -0.8 0.5 -0.4 -0.4 -0.7 -0.7 -0.3 -0.0 -0.0 -0.6 -0.8 -0.2 -0.5 -0.3 -0.9 -1.0
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.3 -0.0 -0.2 -0.1 0.0 0.1 0.1 -0.2 0.0 0.1 0.0 0.3 -0.1 -0.0 0.2 -0.2 0.1 -0.1 0.1 -0.0
Angina 0.9 1.2 3.1 1.4 -1.2 -1.1 0.4 -1.3 -0.3 -0.8 -1.0 -1.2 -1.4 -1.1 0.5 -0.9 -1.3 -1.3 -1.2 -1.2 -1.0 -0.2 -1.8
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.4 -0.3 -0.2 0.3 -0.2 0.3 -0.2 -0.2 -0.2 -0.3 -0.3 -0.2 -0.1 -0.3 -0.4 -0.1 -0.4 -0.2 -0.4 -0.0
Vitamin and mineral supplements 0.0 0.1 0.3 -0.1 -0.1 0.0 -0.2 0.1 0.2 -0.3 -0.0 -0.0 0.1 -0.2 0.4 -0.5 0.2 0.6 -0.3 -0.0 -0.1 -0.1 -0.3
Supplements: Zinc 0.3 0.3 0.9 1.0 -0.5 -0.3 0.6 -0.6 0.0 -0.4 -0.3 -0.5 -0.8 -0.4 -0.2 -0.1 -0.7 -0.7 -0.4 -0.5 -0.4 -0.7 -0.6
Medication: Co-codamol 1.0 1.2 1.9 1.0 -1.2 -1.1 -0.3 -0.9 -0.9 -1.2 -1.1 -1.1 -1.1 -1.4 1.1 -1.1 -1.1 -0.6 -0.9 -1.2 -1.3 -1.0 -1.4
Medication: Metformin 0.0 0.0 0.2 -0.3 0.1 0.1 0.3 0.3 0.5 0.2 0.1 0.0 0.1 0.2 -0.1 0.1 -0.0 0.1 0.0 0.2 0.2 -0.0 -0.2
Diabetes (father) 0.2 0.2 1.0 -1.0 0.4 0.3 -0.3 0.7 -0.2 0.3 0.2 0.4 0.6 0.4 0.1 0.2 0.4 0.6 0.6 0.5 0.3 0.4 0.8
Diabetes (mother) 2.1 2.7 5.0 1.2 -1.7 -1.5 0.5 -2.1 -0.8 -1.5 -1.4 -2.0 -2.0 -1.5 0.5 -1.4 -2.0 -1.9 -1.9 -1.7 -1.5 -1.8 -2.2
Severe depression (siblings) 6.9 7.8 11.0 2.8 -3.0 -2.9 0.7 -3.3 -1.5 -2.6 -2.8 -3.1 -3.2 -2.7 1.2 -3.0 -3.2 -3.1 -3.0 -3.1 -2.7 -2.9 -3.3
Pack years adult smoking proportion 0.2 0.3 0.9 -0.5 -0.6 -0.6 -0.6 -0.2 0.6 -0.4 -0.7 -0.4 -0.4 -0.6 0.9 -0.3 -0.6 0.0 -0.1 -0.5 -0.7 -0.5 -0.7
Impedance of leg (right) 0.6 2.9 9.6 2.7 -1.2 -1.0 1.8 -2.1 -3.1 -1.0 -0.8 -1.6 -1.9 -0.9 -0.4 -1.1 -1.6 -2.2 -2.2 -1.3 -0.9 -1.8 -1.5
Leg fat-free mass (left) 0.3 1.5 5.2 -2.2 1.0 0.9 -0.8 1.6 2.3 0.8 0.7 1.2 1.4 0.7 -0.0 0.9 1.2 1.4 1.5 1.0 0.8 1.4 1.0
Trunk fat percentage 0.1 0.3 1.4 -0.3 -0.3 -0.2 1.2 -0.5 0.4 -0.3 -0.1 -0.4 -0.7 -0.2 -0.6 -0.2 -0.4 -0.9 -0.7 -0.4 -0.0 -0.5 -0.2
Hand grip strength (right) 1.3 3.6 8.1 -2.7 1.8 1.5 -1.7 2.6 1.1 1.3 1.2 2.0 2.6 1.3 0.4 1.2 2.0 2.9 2.2 1.8 1.2 1.8 2.4
Townsend deprivation index at recruitment 0.5 0.8 3.9 -1.8 0.4 0.4 -0.8 0.9 2.0 0.6 0.4 0.8 0.7 0.0 0.3 0.7 0.5 1.2 1.4 0.3 0.1 0.7 0.1
Current tobacco smoking 0.3 0.5 4.2 -1.6 0.2 0.2 -0.8 0.6 2.0 0.3 0.1 0.4 0.5 -0.1 0.3 0.2 0.4 0.9 0.7 0.1 0.0 0.1 -0.3
Average weekly fortified wine intake 0.9 1.0 1.5 0.9 -1.1 -1.1 0.2 -1.1 -1.2 -1.0 -1.1 -1.1 -1.1 -0.9 0.6 -1.0 -1.1 -1.2 -1.0 -1.1 -1.1 -1.1 -0.6
Maternal smoking around birth 0.1 0.1 0.5 -0.3 -0.1 -0.2 -0.7 0.2 0.4 -0.1 -0.2 0.1 0.2 -0.3 0.6 0.1 0.1 0.4 0.6 -0.1 -0.3 -0.2 0.2
Fed-up feelings 0.5 1.0 3.8 -0.4 1.1 1.2 0.1 0.9 1.9 1.0 1.2 1.0 0.9 1.0 -0.9 0.9 0.8 0.9 1.0 1.0 1.1 0.6 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 4.3 -0.2 1.0 1.0 -0.2 0.9 2.1 1.0 1.0 1.0 1.0 1.0 -0.6 1.1 0.9 1.0 1.2 1.1 1.0 0.9 0.8
Relative age voice broke 1.0 1.5 3.0 0.8 1.5 1.7 0.6 1.0 -0.4 1.4 1.7 1.3 1.1 1.4 -1.5 1.5 1.4 0.8 0.7 1.3 1.5 1.0 1.2
Taking other prescription medications 1.9 2.9 6.5 -1.7 1.7 1.8 -0.1 1.7 2.5 1.7 1.8 1.8 1.6 1.5 -1.0 1.8 1.8 1.7 2.0 1.7 1.6 1.8 1.4
Age when periods started (menarche) 0.8 1.9 4.2 0.1 -1.5 -1.4 -0.2 -1.2 -1.2 -1.5 -1.4 -1.5 -1.6 -1.5 0.9 -1.6 -1.3 -1.1 -1.5 -1.5 -1.5 -2.0 -1.3
Bilateral oophorectomy (both ovaries removed) 5.0 5.7 10.0 1.5 -2.4 -2.3 1.0 -2.9 -3.2 -2.4 -2.2 -2.8 -2.8 -2.1 0.5 -2.3 -2.8 -3.1 -2.5 -2.5 -2.0 -2.7 -2.2
Heel bone mineral density (BMD) T-score, automated (left) 0.9 1.9 3.5 -0.8 1.6 1.5 0.3 1.1 1.1 1.6 1.4 1.4 1.5 1.9 -1.3 1.7 1.4 0.8 1.0 1.7 1.6 1.5 1.8
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 3.3 -1.3 1.5 1.7 1.0 1.1 1.4 1.6 1.8 1.3 1.0 1.5 -1.7 1.8 1.3 0.7 1.2 1.4 1.6 1.0 0.6
Qualifications: CSEs or equivalent 1.9 2.5 4.6 -2.0 1.4 1.2 -1.7 1.9 1.8 1.1 0.9 1.7 2.1 1.0 0.5 1.0 1.6 2.1 1.9 1.4 1.0 1.9 1.9
Serious illness, injury or assault to yourself 2.6 3.1 5.7 0.7 2.0 2.2 1.8 1.1 -0.0 2.2 2.3 1.8 1.4 2.2 -2.4 2.2 1.8 0.6 1.1 2.0 2.3 1.8 1.2
High blood pressure 0.2 0.6 4.9 0.3 0.1 0.4 2.2 -0.6 -0.3 0.4 0.6 -0.2 -0.7 0.4 -1.6 0.5 -0.3 -1.1 -0.4 -0.0 0.5 -0.5 -0.4
Hayfever, allergic rhinitis or eczema 1.6 3.6 7.3 -2.7 1.6 1.4 -1.6 2.4 1.6 1.3 1.2 1.9 2.3 1.3 0.1 1.5 1.8 2.3 2.6 1.7 1.2 2.7 2.4
Multivitamins +/- minerals 0.1 0.2 1.0 -0.6 0.1 0.1 -0.8 0.3 0.7 0.2 0.0 0.3 0.3 -0.0 0.3 0.3 0.0 0.4 1.0 0.1 -0.0 0.2 0.3
Stomach or abdominal pain in last month 0.8 1.0 4.2 0.4 0.9 1.1 1.8 0.1 0.7 1.1 1.3 0.6 0.2 1.2 -2.1 1.0 0.6 -0.6 0.3 0.8 1.3 0.4 0.0
Supplements: Glucosamine 0.5 0.7 3.4 -1.7 0.6 0.5 -0.5 1.0 1.8 0.6 0.5 0.7 0.8 0.5 -0.1 0.6 0.7 0.7 1.2 0.6 0.5 0.4 0.5
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 7.1 -0.8 -0.5 -0.7 -2.7 0.5 1.1 -0.8 -0.9 -0.0 0.5 -1.0 2.2 -1.0 -0.1 1.5 0.7 -0.4 -0.9 0.4 0.1
Medication: Atenolol 0.4 0.6 4.1 0.4 -0.0 0.1 2.0 -0.8 -0.3 0.4 0.3 -0.3 -0.7 0.3 -1.4 0.3 -0.2 -1.3 -0.7 -0.2 0.3 -0.0 -0.9
Medication: Levothyroxine sodium 0.8 1.3 9.0 -1.3 -0.3 -0.5 -2.4 0.5 3.0 -0.6 -0.7 0.1 0.5 -0.9 1.9 -0.3 0.1 1.4 1.2 -0.4 -0.8 0.2 -0.2
Sitting height 0.1 0.9 4.9 -1.4 -0.2 -0.4 -2.2 0.9 0.3 -0.6 -0.6 0.2 0.8 -0.8 1.8 -0.8 0.2 1.3 0.4 -0.3 -0.8 0.7 0.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 0.5 0.3 0.5 -0.2 0.3 0.3 0.3 0.5 0.3 0.3 0.2 -0.2 0.2 0.3 0.5 0.5 0.3 0.4 -0.4 0.0
High blood pressure (mother) 1.9 2.7 7.4 -2.7 1.7 1.7 0.0 1.9 1.3 1.6 1.6 1.8 1.8 1.5 -1.0 1.6 1.7 1.7 1.8 1.7 1.5 1.2 1.6
Body mass index (BMI) 0.2 0.8 3.2 -1.5 0.8 0.9 0.6 0.8 1.8 0.8 0.9 0.8 0.6 0.9 -1.0 1.0 0.7 0.3 0.8 0.8 1.0 0.8 0.6
Impedance of leg (left) 0.6 2.9 7.0 2.3 -1.5 -1.3 1.2 -2.1 -2.6 -1.3 -1.2 -1.8 -2.0 -1.2 0.2 -1.3 -1.8 -2.1 -2.3 -1.6 -1.2 -2.1 -1.4
Leg predicted mass (left) 0.3 1.5 5.2 -2.3 0.9 0.8 -0.9 1.6 2.3 0.8 0.7 1.2 1.4 0.7 0.0 0.8 1.1 1.4 1.5 0.9 0.7 1.4 1.0
Trunk fat mass 0.0 0.1 0.8 -0.8 -0.1 -0.0 0.8 -0.0 0.9 -0.1 0.0 -0.1 -0.3 -0.1 -0.4 -0.0 -0.1 -0.5 -0.2 -0.2 0.1 -0.2 -0.0
Waist circumference 0.1 0.3 1.7 -1.0 -0.0 0.1 1.3 -0.2 0.8 0.3 0.2 -0.1 -0.5 0.2 -0.9 0.4 -0.2 -0.8 -0.3 -0.1 0.3 -0.3 -0.4
Number of incorrect matches in round 0.5 0.9 1.9 0.1 1.0 1.0 0.8 1.0 -0.1 1.2 1.1 1.0 0.7 1.0 -1.1 1.0 1.0 0.5 0.6 1.0 1.1 1.4 1.0
Past tobacco smoking 0.0 0.0 0.3 -0.2 -0.0 -0.3 -0.1 -0.0 0.3 -0.1 -0.3 -0.1 0.2 0.1 0.2 -0.5 -0.3 -0.2 0.1 0.0 -0.0 0.2 0.4
Alcohol usually taken with meals 0.5 0.8 4.5 2.1 -0.8 -0.9 -0.2 -1.1 0.4 -0.8 -0.8 -0.8 -0.7 -0.6 0.5 -0.9 -0.9 -0.9 -0.9 -0.7 -0.7 -0.2 -0.7
Nervous feelings 0.4 0.8 2.5 0.9 -1.0 -0.9 0.3 -1.0 -0.3 -1.1 -0.9 -1.0 -0.9 -1.0 0.4 -1.6 -1.0 -0.9 -0.9 -1.1 -0.9 -0.7 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.1 -0.5 1.2 1.2 0.2 1.2 1.0 1.0 1.2 1.1 1.2 1.2 -0.8 0.8 1.2 1.1 1.4 1.3 1.2 1.2 1.5
Hearing difficulty/problems with background noise 1.2 1.9 3.6 0.6 -1.6 -1.5 -0.8 -1.3 1.3 -1.5 -1.5 -1.4 -1.3 -1.6 1.4 -1.2 -1.3 -0.7 -1.2 -1.5 -1.6 -1.9 -1.8
Hair/balding pattern: Pattern 2 0.2 0.3 0.9 0.5 -0.5 -0.5 -0.4 -0.2 -0.9 -0.7 -0.6 -0.5 -0.3 -0.7 0.7 -1.0 -0.4 0.0 -0.1 -0.5 -0.6 -0.4 0.0
Had menopause 0.7 0.8 1.8 0.7 -0.8 -0.7 1.0 -1.1 -1.1 -0.6 -0.5 -1.1 -1.1 -0.6 -0.2 -0.9 -0.7 -1.3 -1.2 -0.9 -0.5 -0.9 -1.1
Had other major operations 0.2 0.3 1.1 1.0 -0.3 -0.2 0.7 -0.6 -0.5 -0.3 -0.1 -0.5 -0.7 -0.2 -0.4 -0.1 -0.4 -0.8 -0.8 -0.4 -0.1 -0.7 -0.6
Forced vital capacity (FVC) 0.5 2.0 3.7 -1.2 1.5 1.4 -0.5 1.6 0.6 1.4 1.2 1.6 1.8 1.4 -0.4 1.2 1.6 1.6 1.6 1.6 1.3 1.6 1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.7 6.5 -1.4 2.2 2.0 0.5 1.7 1.8 2.1 1.9 2.0 2.0 2.5 -1.8 2.1 1.9 1.2 1.3 2.3 2.2 2.0 2.5
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.5 1.3 -0.6 -0.5 1.3 -1.2 -0.1 -0.2 -0.3 -0.8 -1.2 -0.3 -0.7 0.1 -0.9 -1.6 -1.1 -0.7 -0.3 -1.3 -1.1
Qualifications: None of the above 0.0 0.1 0.5 0.1 0.0 -0.0 0.3 -0.3 -0.2 0.4 0.1 -0.1 -0.2 0.1 -0.5 0.7 -0.1 -0.4 -0.1 -0.1 0.1 0.1 -0.1
Financial difficulties in last 2 years 7.1 9.5 13.2 -3.0 3.2 3.0 -1.1 3.5 2.6 3.2 2.9 3.5 3.6 2.9 -1.3 3.4 3.3 3.5 3.6 3.2 2.9 3.2 3.2
Mouth/teeth dental problems 0.1 0.2 1.1 -0.1 0.4 0.3 0.2 0.3 -1.0 0.1 0.2 0.2 0.4 0.3 -0.3 0.1 0.3 0.0 0.1 0.3 0.3 0.4 1.1
Heart attack 0.2 0.3 1.7 -0.6 -0.2 -0.1 1.3 -0.5 -0.9 -0.0 -0.0 -0.4 -0.6 -0.1 -0.6 0.1 -0.2 -0.8 -0.6 -0.3 -0.0 -0.1 -0.7
Allergy 0.9 2.0 4.1 1.9 -1.0 -0.7 1.9 -1.8 -1.4 -0.7 -0.6 -1.4 -1.8 -0.7 -0.6 -1.0 -1.2 -1.9 -2.0 -1.1 -0.6 -2.0 -1.7
Pain all over the body in last month 1.0 1.1 2.8 -1.3 1.0 0.8 -0.1 1.2 0.2 1.0 0.8 1.1 1.1 0.9 -0.5 1.0 1.2 1.1 1.3 1.0 0.9 1.7 1.4
Diabetes (self-reported) 0.1 0.2 0.5 -0.1 -0.3 -0.2 0.6 -0.2 -0.5 -0.3 -0.2 -0.5 -0.6 -0.3 -0.2 -0.1 -0.4 -0.4 -0.4 -0.4 -0.2 -0.6 -0.7
Hayfever/allergic rhinitis (self-reported) 2.0 2.6 4.7 -1.9 1.6 1.4 -0.8 2.1 1.0 1.4 1.3 1.8 2.1 1.3 -0.1 1.3 1.8 2.2 2.0 1.6 1.3 1.9 1.8
Medication: Ramipril 0.4 0.5 3.9 -0.1 0.3 0.5 2.0 -0.1 -1.3 0.7 0.6 0.1 -0.3 0.5 -1.3 0.7 0.1 -0.6 -0.7 0.2 0.6 -0.2 0.0
Medication: Simvastatin 0.5 0.7 1.9 -0.1 -0.9 -1.0 0.2 -0.7 -1.4 -0.9 -1.0 -1.0 -0.9 -0.8 0.6 -0.7 -0.9 -0.8 -1.0 -0.8 -0.9 -0.7 -0.7
Fluid intelligence score 0.4 0.9 5.8 -0.9 0.8 0.8 -0.8 0.9 2.4 0.8 0.6 0.9 1.0 0.9 -0.1 0.6 0.8 0.9 0.8 0.9 0.8 1.0 0.8
Illnesses of siblings 0.3 0.5 1.6 0.1 -0.7 -0.9 -1.3 -0.3 0.6 -0.9 -1.0 -0.4 -0.2 -0.9 1.2 -0.7 -0.4 0.1 0.1 -0.7 -1.0 -0.3 -0.1
Neuroticism score 0.1 0.1 0.4 0.4 -0.2 -0.1 0.4 -0.4 0.6 -0.2 -0.1 -0.3 -0.3 -0.1 -0.3 -0.6 -0.4 -0.4 -0.1 -0.2 -0.1 -0.4 -0.4
Weight 0.2 1.0 3.5 -1.9 0.8 0.9 0.2 1.1 1.8 0.8 0.8 0.9 0.9 0.8 -0.6 0.9 0.9 0.6 1.0 0.8 0.9 1.0 0.8
Impedance of arm (right) 0.0 0.1 1.1 0.7 0.1 0.1 0.2 -0.1 -1.0 0.0 0.2 0.1 -0.0 0.1 -0.1 -0.2 0.1 0.1 -0.6 0.1 0.1 0.2 0.4
Arm fat percentage (right) 0.1 0.2 2.1 -0.7 0.2 0.4 0.7 0.2 1.4 0.3 0.4 0.2 -0.0 0.3 -0.7 0.4 0.2 -0.2 0.0 0.2 0.4 0.2 0.0
Trunk fat-free mass 0.3 1.6 3.9 -2.0 1.0 0.9 -1.3 1.6 1.9 0.9 0.7 1.3 1.6 0.7 0.2 1.0 1.2 1.6 1.8 1.0 0.7 1.3 1.0
Hip circumference 0.5 2.0 4.8 -2.2 1.4 1.4 0.4 1.6 1.5 1.3 1.4 1.5 1.4 1.4 -1.2 1.5 1.5 0.9 1.4 1.4 1.5 1.7 1.5
Time employed in main current job 0.7 0.8 2.4 0.2 -1.0 -0.9 -0.5 -0.7 -0.1 -1.0 -1.0 -0.9 -0.7 -1.1 1.1 -1.6 -0.8 -0.4 -0.3 -1.0 -1.1 -0.8 -0.7
Alcohol intake versus 10 years previously 1.1 1.7 3.1 -1.1 1.4 1.4 0.2 1.3 0.5 1.5 1.4 1.4 1.3 1.4 -1.1 1.8 1.3 1.0 1.4 1.3 1.4 1.6 1.4
Father’s age at death 5.0 6.7 9.6 3.0 -2.7 -2.7 0.1 -2.8 -2.1 -2.8 -2.6 -2.9 -2.8 -2.6 1.6 -2.7 -2.6 -2.5 -3.1 -2.7 -2.5 -2.7 -2.8
Worrier / anxious feelings 0.3 0.6 2.3 1.5 -0.6 -0.4 0.9 -0.9 -0.6 -0.5 -0.4 -0.7 -0.9 -0.4 -0.3 -0.7 -0.8 -1.1 -0.8 -0.6 -0.4 -1.1 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 4.1 -0.5 1.2 1.1 0.1 1.0 2.0 1.5 1.1 1.2 1.1 1.3 -0.8 1.2 0.9 0.8 1.6 1.3 1.2 1.5 1.0
Falls in the last year 0.9 1.2 4.7 -1.2 0.5 0.3 -2.2 1.5 1.3 -0.1 0.2 0.8 1.3 -0.1 1.3 -0.1 0.9 2.0 1.5 0.5 -0.0 0.6 1.1
Hair/balding pattern: Pattern 3 0.3 0.5 1.4 -0.8 0.6 0.5 -0.9 0.9 0.8 0.5 0.4 0.8 0.9 0.4 0.3 0.5 0.6 1.2 1.0 0.7 0.3 0.9 0.3
Number of live births 0.8 1.1 2.6 -1.4 1.0 0.7 -0.5 1.1 0.6 1.1 0.7 1.1 1.3 1.0 0.0 0.9 1.0 1.3 0.9 1.1 0.9 1.6 1.2
Forced expiratory volume in 1-second (FEV1) 1.3 4.5 6.5 -1.8 2.4 2.3 0.2 2.2 1.3 2.3 2.1 2.4 2.4 2.3 -1.4 1.9 2.4 1.9 1.9 2.4 2.2 2.5 2.5
Pulse rate 1.7 3.0 4.8 1.4 -1.9 -1.8 -0.8 -1.7 0.2 -2.0 -1.8 -1.9 -1.7 -1.9 1.7 -2.2 -1.9 -1.3 -1.5 -1.8 -1.9 -1.7 -2.1
Happiness 3.6 4.4 5.8 -1.9 2.4 2.3 0.7 2.0 1.6 2.4 2.4 2.2 2.2 2.3 -1.6 1.8 2.4 1.8 1.8 2.3 2.4 2.4 2.0
Noisy workplace 0.2 0.2 1.3 0.4 0.4 0.6 0.3 0.3 -1.1 0.3 0.6 0.2 0.2 0.4 -0.5 0.5 0.2 0.0 0.6 0.3 0.4 -0.0 0.4
Qualifications: A levels/AS levels or equivalent 1.5 3.3 8.0 2.8 -1.9 -1.8 0.5 -2.1 -0.9 -1.8 -1.6 -1.9 -1.9 -1.7 1.0 -2.1 -1.9 -1.8 -2.2 -1.8 -1.7 -1.6 -1.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.6 0.2 -0.2 -0.2 0.8 -0.3 0.3 -0.2 -0.1 -0.3 -0.4 -0.1 -0.2 -0.4 -0.1 -0.4 -0.4 -0.2 -0.1 -0.2 -0.3
Mouth/teeth dental problems: Dentures 0.4 0.7 1.9 0.5 -0.9 -0.9 0.2 -1.1 -0.2 -0.6 -0.8 -0.9 -1.1 -0.8 0.5 -0.5 -0.8 -0.9 -1.3 -0.9 -0.8 -0.6 -1.4
Asthma 0.6 1.2 2.5 -0.1 -1.3 -1.3 -1.1 -0.7 0.7 -1.3 -1.3 -1.0 -0.8 -1.6 1.4 -1.3 -1.2 -0.3 -0.6 -1.4 -1.5 -0.7 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.4 0.2 -0.7 -0.9 -1.1 -0.5 0.2 -0.7 -0.9 -0.5 -0.4 -0.8 1.2 -0.5 -0.7 -0.1 -0.3 -0.6 -0.9 -0.2 -0.5
Medication: Cholesterol lowering 0.2 0.3 1.2 0.6 -0.6 -0.4 0.5 -0.7 -0.0 -0.4 -0.4 -0.7 -0.9 -0.4 -0.1 -0.3 -0.5 -0.7 -0.5 -0.6 -0.4 -0.5 -1.1
Depression (self-reported) 0.7 0.8 1.4 0.6 -1.0 -1.0 -0.1 -1.0 0.6 -1.1 -0.9 -0.9 -0.9 -1.2 0.8 -1.0 -0.9 -0.5 -0.6 -1.1 -1.1 -0.8 -1.1
Medication: Lansoprazole 1.3 1.5 2.7 1.1 -1.1 -0.9 1.1 -1.3 -1.5 -1.1 -0.7 -1.4 -1.6 -1.0 -0.1 -1.1 -1.2 -1.6 -1.3 -1.3 -0.9 -1.6 -1.5
Prospective memory result 3.0 3.7 6.0 1.2 -2.1 -2.1 -0.4 -1.7 -2.1 -2.1 -2.1 -2.0 -1.9 -2.1 1.7 -2.2 -2.2 -1.3 -1.9 -1.9 -2.1 -1.9 -2.5
Lung cancer (father) 0.0 0.0 0.2 -0.5 -0.1 0.0 0.3 0.0 0.0 -0.0 -0.1 -0.2 -0.3 -0.1 -0.2 0.1 -0.2 -0.2 -0.1 -0.2 -0.1 -0.2 -0.5
Illnesses of mother 1.3 1.6 3.0 1.7 -1.1 -1.2 1.2 -1.5 -1.6 -1.0 -1.0 -1.4 -1.5 -0.7 0.1 -1.3 -1.3 -1.7 -1.7 -1.1 -0.8 -0.5 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.7 8.8 -2.0 2.7 2.5 -0.0 2.6 1.1 2.6 2.4 2.7 2.8 2.6 -1.5 2.4 2.7 2.3 2.2 2.7 2.5 2.7 3.0
Pulse wave Arterial Stiffness index 0.1 0.1 0.9 1.0 -0.1 0.1 0.2 -0.3 0.5 -0.2 0.1 -0.1 -0.2 -0.1 -0.3 0.0 -0.0 -0.3 -0.1 -0.1 -0.0 0.1 -0.5
Impedance of arm (left) 0.0 0.2 1.1 0.9 -0.1 0.0 0.5 -0.3 -1.1 -0.1 0.1 -0.1 -0.2 0.0 -0.2 -0.3 -0.1 -0.1 -0.9 0.0 0.0 0.0 0.3
Arm fat mass (right) 0.1 0.6 3.6 -1.3 0.6 0.7 0.3 0.7 1.9 0.5 0.6 0.6 0.5 0.5 -0.6 0.7 0.6 0.3 0.7 0.5 0.7 0.6 0.4
Trunk predicted mass 0.3 1.7 3.9 -2.0 1.1 1.0 -1.2 1.7 1.9 1.0 0.8 1.4 1.7 0.8 0.2 1.1 1.3 1.6 1.9 1.1 0.8 1.4 1.1
Standing height 0.1 0.6 1.5 -1.2 0.6 0.5 -0.8 1.1 0.2 0.4 0.4 0.8 1.1 0.3 0.4 0.3 0.8 1.1 0.8 0.6 0.3 0.9 1.1
Length of working week for main job 0.8 0.9 3.1 -1.3 0.5 0.4 -1.8 1.1 1.2 0.3 0.3 0.8 0.9 0.1 0.7 0.8 0.8 1.5 1.7 0.5 0.2 0.6 0.7
Exposure to tobacco smoke at home 0.7 0.8 1.1 0.4 -0.9 -0.9 -0.6 -0.7 -1.0 -1.0 -0.8 -0.9 -0.8 -1.0 1.0 -0.9 -1.0 -0.4 -0.9 -1.0 -1.0 -1.0 -1.0
Breastfed as a baby 0.1 0.2 0.8 0.9 0.2 0.3 0.3 -0.0 -0.9 0.2 0.4 0.2 0.1 0.3 -0.6 0.3 0.3 -0.2 0.4 0.2 0.3 0.5 0.1
Tense / ‘highly strung’ 0.1 0.2 0.8 0.3 -0.4 -0.4 -0.0 -0.3 -0.1 -0.5 -0.4 -0.4 -0.3 -0.5 0.3 -0.9 -0.4 -0.0 -0.0 -0.4 -0.4 -0.6 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 3.5 1.9 -1.1 -1.0 0.8 -1.4 -0.3 -1.2 -0.8 -1.3 -1.3 -1.0 0.1 -1.5 -1.3 -1.3 -1.2 -1.1 -0.9 -1.0 -1.1
Hair/balding pattern: Pattern 4 1.4 3.4 10.2 -3.2 1.8 1.6 -0.3 2.2 1.8 1.7 1.4 1.9 2.1 1.7 -0.4 1.4 1.9 2.0 2.3 1.9 1.5 2.1 1.9
Birth weight of first child 0.3 0.6 1.3 1.1 0.8 0.8 -0.3 0.7 1.1 0.5 0.7 0.8 0.9 0.7 -0.6 0.6 1.0 0.7 0.3 0.8 0.7 0.6 0.7
Peak expiratory flow (PEF) 0.4 0.9 2.0 -0.3 1.1 0.9 -0.0 0.9 1.1 1.0 0.9 1.1 1.2 1.1 -0.5 0.4 1.1 0.8 0.9 1.2 1.0 1.1 1.4
Pulse wave reflection index 0.4 0.5 2.5 1.6 -0.5 -0.4 0.6 -1.0 -0.6 -0.5 -0.3 -0.5 -0.7 -0.4 -0.3 -0.1 -0.5 -1.0 -0.9 -0.6 -0.3 -0.7 -0.7
Ever highly irritable/argumentative for 2 days 2.5 3.1 4.6 -1.7 1.9 1.7 -0.4 1.9 0.9 1.9 1.6 2.0 2.1 1.8 -0.7 2.1 2.0 2.1 1.9 2.0 1.7 1.5 1.8
Loud music exposure frequency 0.1 0.1 0.6 0.7 0.0 -0.1 0.6 -0.3 -0.4 0.4 -0.0 -0.0 -0.2 0.3 -0.3 0.3 -0.2 -0.6 -0.2 0.1 0.2 0.4 0.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.9 1.4 -0.5 -0.3 0.7 -1.1 0.2 -0.5 -0.2 -0.6 -0.8 -0.4 -0.4 -0.5 -0.5 -1.0 -1.0 -0.6 -0.3 -0.6 -0.8
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 2.0 1.4 -0.4 -0.1 0.9 -0.7 -1.0 -0.3 0.1 -0.6 -1.0 -0.3 -0.7 -0.1 -0.4 -0.8 -0.2 -0.4 -0.1 -0.8 -0.9
Blood clot in the leg (DVT) 0.2 0.3 0.6 0.2 -0.6 -0.7 -0.1 -0.6 -0.4 -0.4 -0.7 -0.7 -0.6 -0.4 0.5 -0.5 -0.6 -0.5 -0.2 -0.4 -0.6 -0.2 -0.8
Medication: Paracetamol 0.1 0.1 0.4 -0.3 -0.2 -0.1 0.5 -0.3 -0.1 0.1 -0.0 -0.2 -0.5 -0.0 -0.4 0.5 -0.3 -0.6 0.0 -0.3 0.0 -0.2 -0.3
Headache pain in last month 1.3 2.2 6.1 0.4 1.5 1.7 2.1 0.8 0.6 1.9 1.8 1.3 0.8 1.8 -2.5 2.1 1.2 0.2 1.3 1.4 1.9 0.8 0.8
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.6 0.5 0.6 0.3 -0.2 0.4 -0.2 0.6 0.3 0.5 0.7 0.7 -0.1 0.2 0.5 0.3 0.4 0.7 0.5 0.5 0.8
Glaucoma (self-reported) 1.3 1.6 10.5 2.1 -0.8 -0.7 1.5 -1.4 -3.2 -0.7 -0.7 -1.0 -1.1 -0.4 -0.2 -0.8 -1.0 -1.5 -1.4 -0.7 -0.4 -1.3 0.1
Gout (self-reported) 0.4 0.5 1.2 -1.1 0.7 0.7 0.3 0.8 -0.7 0.7 0.7 0.7 0.6 0.7 -0.4 0.6 0.8 0.7 0.5 0.7 0.7 0.8 1.0
Hypothyroidism/myxoedema (self-reported) 1.5 2.8 9.9 -2.4 1.0 0.8 -2.2 2.0 3.1 0.8 0.6 1.6 1.9 0.5 1.2 0.7 1.6 2.7 2.3 1.1 0.5 1.6 1.5
Medication: Amlodipine 0.3 0.4 1.2 0.2 -0.6 -0.6 -0.2 -0.7 0.3 -0.6 -0.6 -0.7 -0.7 -0.6 0.3 -0.6 -0.7 -0.5 -0.3 -0.7 -0.6 -1.1 -0.8
Medication: Ventolin 100micrograms inhaler 1.8 2.3 6.1 0.0 -1.7 -1.8 -1.8 -0.8 0.7 -1.8 -1.9 -1.3 -0.9 -2.0 2.5 -2.0 -1.4 0.1 -0.8 -1.6 -2.0 -1.6 -1.1
Birth weight 0.3 0.6 1.6 0.8 0.8 0.9 0.7 0.3 -0.4 0.8 0.9 0.7 0.5 1.0 -1.3 1.0 0.6 -0.2 -0.0 0.9 1.0 1.1 0.6
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.6 -0.1 -0.4 -0.4 -0.7 -0.2 -0.0 -0.4 -0.5 -0.3 -0.3 -0.4 0.4 -0.4 -0.5 -0.2 0.1 -0.4 -0.5 -0.8 -0.1
High blood pressure (siblings) 0.3 0.4 2.4 0.0 -0.2 -0.2 1.5 -0.7 -0.6 0.1 -0.1 -0.5 -0.6 0.1 -0.6 -0.4 -0.6 -1.0 -1.2 -0.2 0.0 -0.4 -0.8
Forced vital capacity (FVC), Best measure 0.4 1.6 3.4 -1.1 1.3 1.1 -0.7 1.5 0.2 1.1 1.0 1.4 1.7 1.1 -0.2 1.1 1.4 1.5 1.4 1.3 1.0 1.5 1.9
Body fat percentage 0.1 0.3 2.0 -0.1 -0.3 -0.1 1.4 -0.6 0.4 -0.2 -0.0 -0.5 -0.9 -0.1 -0.8 -0.1 -0.4 -1.1 -0.7 -0.4 -0.0 -0.6 -0.4
Leg fat percentage (right) 0.4 1.4 3.9 0.8 -1.1 -0.8 1.7 -1.5 -0.2 -0.8 -0.7 -1.3 -1.6 -0.7 -0.6 -0.7 -1.3 -2.0 -1.4 -1.1 -0.6 -1.5 -1.4
Arm fat-free mass (right) 0.1 0.3 1.7 -1.3 0.3 0.1 -0.7 0.7 1.3 0.1 0.0 0.4 0.6 0.1 0.3 0.3 0.3 0.5 0.9 0.2 0.1 0.3 0.3
Exposure to tobacco smoke outside home 0.4 0.6 1.2 -0.8 0.8 0.8 0.0 0.8 -0.3 1.0 0.7 0.9 0.8 0.9 -0.5 0.8 0.8 0.7 0.5 0.9 0.8 0.8 1.1
Comparative body size at age 10 0.2 0.5 3.2 0.5 -0.2 0.0 1.8 -0.6 0.0 0.1 0.2 -0.6 -0.9 0.1 -1.1 0.1 -0.5 -1.0 -0.4 -0.2 0.1 -1.0 -1.2
Number of full brothers 0.9 1.2 2.0 0.7 -1.2 -1.2 -1.4 -0.9 0.5 -1.2 -1.2 -0.9 -0.8 -1.4 1.3 -1.0 -1.0 -0.4 -0.8 -1.2 -1.4 -1.0 -1.2
Worry too long after embarrassment 0.0 0.1 0.9 0.9 0.1 0.2 0.4 -0.1 0.3 0.1 0.1 -0.0 -0.0 0.3 -0.4 -0.2 -0.1 -0.3 0.3 0.2 0.2 -0.2 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.6 1.3 -0.8 -0.7 1.1 -1.2 -0.6 -0.9 -0.5 -1.0 -1.2 -0.6 -0.3 -1.0 -0.9 -1.1 -1.3 -0.8 -0.6 -0.7 -0.8
Wheeze or whistling in the chest in last year 0.2 0.4 1.5 -1.2 0.6 0.6 0.0 0.9 1.1 0.5 0.7 0.5 0.5 0.4 -0.3 0.1 0.5 0.7 0.9 0.5 0.5 0.1 0.5
Number of children fathered 0.1 0.1 0.4 0.6 0.1 0.1 0.0 -0.1 -0.3 -0.0 0.2 -0.0 -0.1 0.2 -0.5 0.2 0.1 -0.3 -0.2 0.1 0.2 0.2 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.5 0.6 -0.3 -0.2 1.9 -1.2 -1.1 -0.0 0.0 -0.8 -1.1 0.0 -1.1 -0.4 -0.7 -1.6 -1.2 -0.5 0.0 -0.5 -1.1
Age at first live birth 3.6 6.4 9.2 -1.6 2.9 2.9 1.5 2.6 0.5 3.0 2.9 2.7 2.4 3.0 -2.6 2.8 2.7 1.7 2.2 2.9 3.0 2.4 2.7
Pulse wave peak to peak time 0.2 0.2 1.3 -1.2 0.3 0.1 -0.2 0.6 -0.6 0.4 0.1 0.3 0.4 0.4 0.2 0.2 0.2 0.5 0.3 0.4 0.2 0.1 0.7
Health satisfaction 3.9 5.1 8.1 -1.1 2.5 2.4 1.4 1.9 1.7 2.8 2.6 2.3 1.9 2.7 -2.4 2.4 2.4 1.2 2.1 2.4 2.6 2.8 2.3
Shortness of breath walking on level ground 0.9 1.1 3.3 -1.8 1.1 1.1 0.7 1.1 0.7 1.0 1.1 1.0 1.0 1.0 -0.7 0.8 1.0 1.0 1.1 1.1 1.1 1.0 0.7
Qualifications: College or University degree 0.2 0.6 1.1 0.8 -0.8 -0.7 0.2 -0.7 0.1 -0.8 -0.6 -0.7 -0.9 -0.8 0.4 -0.9 -0.8 -0.8 -0.9 -0.8 -0.7 -1.1 -0.9
Eye problems/disorders: None of the above 0.3 0.4 1.1 -0.1 -0.5 -0.5 0.2 -0.6 0.4 -0.5 -0.5 -0.6 -0.7 -0.5 0.2 -0.8 -0.6 -0.7 -1.0 -0.6 -0.5 -0.2 -1.1
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.9 -0.5 -0.2 -0.1 0.6 -0.4 -0.1 -0.1 0.0 -0.2 -0.4 -0.1 -0.4 -0.1 -0.3 -0.5 -0.6 -0.3 0.0 -0.6 -1.0
Emphysema/chronic bronchitis 0.1 0.1 1.3 1.2 -0.0 -0.0 -0.1 0.1 -1.1 -0.1 -0.0 -0.1 -0.0 -0.1 0.1 -0.4 -0.2 0.1 -0.0 -0.0 -0.0 -0.2 0.0
Medication for pain relief, constipation, heartburn 0.0 0.1 0.4 -0.0 0.3 0.3 -0.4 0.3 0.6 0.1 0.2 0.2 0.3 0.2 -0.0 -0.2 0.2 0.3 0.0 0.3 0.2 0.1 0.2
Neck or shoulder pain in last month 1.3 1.9 2.6 1.4 -1.5 -1.5 0.3 -1.5 -0.9 -1.2 -1.4 -1.6 -1.6 -1.3 0.8 -1.2 -1.6 -1.6 -1.5 -1.4 -1.3 -1.5 -1.6
Medication: Blood pressure 0.3 0.6 1.3 0.1 -0.7 -0.5 0.9 -0.9 0.7 -0.6 -0.4 -0.8 -1.1 -0.7 -0.2 -0.5 -0.9 -1.0 -0.8 -0.8 -0.5 -0.8 -1.1
Angina (self-reported) 0.6 0.8 2.4 1.4 -0.9 -0.8 0.6 -1.2 -0.2 -0.5 -0.7 -1.0 -1.2 -0.8 0.2 -0.6 -1.0 -1.2 -1.1 -1.0 -0.7 -0.1 -1.6
Migraine (self-reported) 1.0 1.2 1.7 -1.3 1.2 1.2 0.6 1.2 0.9 1.2 1.1 1.2 1.1 1.3 -1.0 1.1 1.2 0.8 0.9 1.2 1.3 1.2 1.1
Medication: Ibuprofen 0.2 0.2 0.9 0.2 -0.3 -0.5 -1.0 -0.2 0.9 -0.3 -0.5 -0.1 0.0 -0.4 0.9 -0.1 -0.3 0.2 0.1 -0.2 -0.5 0.2 -0.2
Medication: Allopurinol 0.9 1.2 2.6 -1.6 1.0 0.9 -0.9 1.4 1.3 0.9 0.8 1.2 1.3 0.7 0.1 0.9 1.2 1.6 1.1 0.9 0.7 1.3 1.2
Medication: Omeprazole 0.6 0.7 1.7 0.4 0.8 0.9 0.8 0.3 -0.8 1.1 1.0 0.7 0.5 1.0 -1.3 1.3 0.8 -0.1 0.6 0.7 1.0 0.7 0.8
Medication: Seretide 50 evohaler 0.1 0.1 1.8 0.4 -0.1 -0.1 -0.3 -0.1 1.3 -0.1 -0.1 -0.1 0.0 -0.1 0.2 -0.4 -0.0 0.1 -0.1 -0.1 -0.1 -0.1 -0.2
Mean time to correctly identify matches 0.6 1.1 4.1 1.8 -0.4 -0.3 2.0 -1.5 -1.8 -0.1 -0.1 -0.9 -1.2 0.1 -1.1 -0.3 -0.6 -1.8 -1.1 -0.5 0.0 -0.4 -0.8
Heart disease (mother) 1.1 1.3 3.2 -1.6 1.1 1.0 -0.7 1.5 1.2 0.9 1.0 1.3 1.4 0.8 -0.0 0.7 1.3 1.8 0.9 1.1 0.8 1.1 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.2 0.1 -0.9 -1.1 -0.6 -1.0 -0.2 -0.9 -1.1 -0.9 -0.8 -0.8 0.9 -0.7 -1.0 -0.7 -1.0 -0.9 -0.8 -0.6 -1.0
Whole body fat mass 0.1 0.2 1.2 -1.1 0.1 0.3 0.9 0.1 1.1 0.2 0.3 0.1 -0.2 0.2 -0.7 0.3 0.1 -0.4 0.0 0.1 0.4 0.0 0.0
Leg fat mass (right) 0.1 0.2 1.3 -0.4 -0.1 0.1 1.1 -0.3 1.0 0.0 0.1 -0.2 -0.5 0.1 -0.8 0.2 -0.2 -0.8 -0.3 -0.1 0.2 -0.3 -0.4
Arm predicted mass (right) 0.1 0.3 1.7 -1.3 0.1 0.0 -0.6 0.6 1.2 -0.0 -0.0 0.2 0.5 -0.0 0.4 0.2 0.3 0.4 0.7 0.1 0.0 0.2 0.2
Pulse rate, automated reading 0.1 0.2 0.7 -0.6 0.4 0.4 -0.8 0.6 0.5 0.2 0.3 0.4 0.5 0.3 0.3 0.1 0.3 0.8 0.7 0.5 0.3 0.0 0.2
Alcohol intake frequency. 0.7 1.7 5.5 -1.9 0.8 0.5 -2.1 1.5 2.3 0.6 0.3 1.1 1.5 0.4 1.1 0.5 1.0 2.0 1.4 0.9 0.3 1.5 1.1
Comparative height size at age 10 0.0 0.1 0.5 -0.6 0.1 0.1 -0.2 0.4 -0.1 0.0 0.1 0.2 0.4 -0.0 0.4 -0.2 0.3 0.7 0.3 0.3 0.0 0.6 0.1
Number of full sisters 0.1 0.1 0.4 -0.3 -0.1 -0.3 -0.4 0.0 0.5 0.2 -0.3 0.1 0.2 -0.0 0.4 -0.1 0.1 0.1 0.2 -0.0 -0.1 0.6 -0.1
Suffer from ‘nerves’ 1.9 3.0 6.3 0.5 -2.0 -2.1 -0.7 -1.5 -0.6 -2.2 -2.1 -1.8 -1.6 -2.2 1.9 -2.5 -1.8 -0.8 -1.6 -2.0 -2.1 -1.6 -1.5
Overall health rating 1.5 3.1 5.2 -1.2 1.9 2.0 1.6 1.3 1.6 2.2 2.2 1.7 1.2 2.0 -2.3 2.0 1.6 0.7 1.7 1.7 2.1 2.2 1.2
Chest pain or discomfort 0.2 0.2 1.9 -0.6 -0.2 -0.2 0.2 -0.4 1.4 0.1 -0.0 -0.3 -0.5 -0.2 -0.1 -0.1 -0.5 -0.3 -0.5 -0.3 -0.1 -0.3 -0.9
Had major operations 1.9 2.3 6.4 -0.4 1.7 1.7 0.5 1.3 1.3 1.9 1.7 1.7 1.3 1.7 -1.5 2.5 1.5 0.9 1.2 1.6 1.7 1.5 1.0
Age at last live birth 1.8 2.5 5.7 -0.5 1.8 1.9 2.1 1.2 0.2 2.0 2.0 1.4 1.0 2.1 -2.4 1.8 1.4 0.4 0.8 1.8 2.1 1.1 1.2
Family relationship satisfaction 0.2 0.2 1.9 0.4 -0.1 0.0 1.4 -0.5 0.3 0.1 0.2 -0.2 -0.5 0.1 -0.7 -0.3 -0.3 -0.7 -0.7 -0.2 0.1 0.5 -0.4
Leg pain on walking 0.2 0.3 0.9 0.5 -0.0 0.1 1.0 -0.4 0.9 0.3 0.3 -0.3 -0.5 0.1 -0.7 0.4 -0.3 -0.7 -0.5 -0.1 0.2 -0.8 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 4.2 -2.0 1.0 1.0 -0.7 1.3 2.0 0.9 0.7 1.3 1.3 0.8 0.2 0.7 1.0 1.6 1.4 1.0 0.7 0.5 0.8
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.5 0.6 -0.4 -0.4 0.9 -0.8 -0.7 -0.4 -0.3 -0.6 -0.7 -0.2 -0.3 -0.1 -0.5 -0.9 -1.2 -0.4 -0.2 -0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 -0.1 -0.5 -0.4 -0.6 -0.2 -0.6 -0.6 -0.4 -0.4 -0.4 -0.7 0.5 -0.4 -0.5 -0.0 -0.4 -0.6 -0.6 -0.8 -0.1
Medication: Aspirin 0.5 0.7 2.1 1.4 -0.4 -0.3 1.4 -0.9 -1.4 -0.2 -0.1 -0.8 -1.0 -0.1 -0.7 -0.3 -0.6 -1.4 -0.8 -0.5 -0.1 -0.9 -0.5
Supplements: Vitamin C 0.9 1.0 3.2 1.1 -1.0 -1.0 0.9 -1.2 -0.8 -0.8 -0.8 -1.1 -1.4 -0.8 -0.1 -0.5 -1.3 -1.8 -0.8 -1.1 -0.8 -1.1 -0.6
Knee pain experienced in last month 0.7 1.1 3.2 -1.0 1.0 1.1 1.1 0.7 1.8 1.5 1.2 0.8 0.4 1.2 -1.4 1.7 0.8 0.2 0.7 0.9 1.2 0.1 -0.1
Hypertension (Self-reported) 0.2 0.6 4.5 -0.5 0.5 0.8 2.1 -0.2 0.1 0.7 0.9 0.2 -0.3 0.7 -1.7 0.8 0.1 -0.6 -0.1 0.4 0.8 -0.2 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 1.9 0.6 -0.1 0.1 0.2 -0.2 -1.4 -0.2 0.2 -0.3 -0.3 -0.0 -0.5 -0.0 0.0 -0.5 -0.4 -0.2 0.0 -0.1 0.1
Illnesses of father: Heart disease 0.4 0.5 2.8 1.7 -0.7 -0.6 0.1 -0.8 -0.4 -0.7 -0.5 -0.7 -0.8 -0.8 0.2 -0.5 -0.5 -0.6 -0.3 -0.8 -0.6 -0.6 -0.7
Illnesses of siblings: Diabetes 0.4 0.5 2.4 0.8 0.0 0.2 1.5 -0.6 -1.5 0.3 0.5 -0.1 -0.6 0.2 -1.2 0.5 -0.2 -1.0 -1.0 -0.1 0.4 -0.2 -0.4
Smoking status: Previous 0.1 0.2 1.4 0.8 -0.0 0.1 0.6 -0.2 -1.2 0.0 0.2 -0.0 -0.3 -0.1 -0.3 0.4 0.1 -0.1 -0.4 -0.1 0.0 -0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.0 -1.4 1.3 1.2 -0.7 1.6 0.7 0.9 1.2 1.4 1.7 1.0 -0.2 0.9 1.3 1.7 1.2 1.3 1.0 1.3 1.4
Whole body fat-free mass 0.3 1.5 4.6 -2.1 0.9 0.8 -1.1 1.6 2.1 0.8 0.6 1.2 1.5 0.6 0.2 0.9 1.1 1.5 1.7 0.9 0.7 1.3 1.0
Leg fat-free mass (right) 0.4 2.0 6.8 -2.6 1.0 0.9 -1.3 1.8 2.5 0.8 0.7 1.3 1.6 0.7 0.2 0.9 1.3 1.7 1.7 1.0 0.8 1.5 1.3
Arm fat percentage (left) 0.1 0.2 1.9 -0.6 0.1 0.3 1.0 -0.0 1.4 0.2 0.4 0.1 -0.3 0.3 -0.8 0.3 0.1 -0.4 -0.2 0.1 0.4 0.0 -0.1
Average weekly red wine intake 0.3 0.5 2.9 1.2 0.3 0.5 1.7 -0.3 -0.8 0.3 0.6 0.0 -0.4 0.4 -1.3 0.3 0.1 -0.8 -0.6 0.2 0.5 -0.1 0.1
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.1 0.1 1.2 1.2 0.3 0.9 -0.3 1.4 1.1 1.2 1.2 1.4 -1.0 1.4 1.1 0.9 1.4 1.4 1.3 1.3 1.2
Mood swings 0.2 0.4 1.7 0.4 0.2 0.3 1.3 -0.4 1.0 0.6 0.4 -0.0 -0.4 0.6 -1.3 0.4 -0.3 -0.9 -0.1 0.2 0.5 -0.1 -0.6
Loneliness, isolation 1.3 1.8 3.5 -1.7 1.4 1.2 -0.2 1.4 1.6 1.3 1.1 1.5 1.6 1.4 -0.6 0.9 1.2 1.4 1.3 1.5 1.3 1.9 1.3
Long-standing illness, disability or infirmity 1.7 2.5 5.7 -0.6 1.6 1.7 0.9 1.4 2.4 1.8 1.8 1.6 1.3 1.5 -1.6 2.0 1.6 1.0 2.0 1.5 1.7 1.5 1.3
Ever had bowel cancer screening 2.4 2.8 8.5 2.9 -1.5 -1.4 1.0 -1.8 -2.4 -1.5 -1.2 -1.9 -1.9 -1.2 0.2 -1.8 -1.7 -2.0 -1.7 -1.5 -1.2 -1.6 -1.4
Diabetes diagnosed by doctor 0.1 0.2 0.6 -0.8 0.4 0.5 0.5 0.6 -0.4 0.3 0.5 0.3 0.3 0.4 -0.5 0.5 0.4 0.3 0.4 0.4 0.4 0.2 0.3
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.1 4.4 -1.5 1.6 1.7 1.5 1.3 -0.6 1.7 1.8 1.4 1.0 1.8 -2.1 1.8 1.5 0.4 1.0 1.5 1.8 0.9 1.3
Friendships satisfaction 0.3 0.3 1.0 -0.4 0.6 0.5 -0.2 0.5 0.7 0.6 0.6 0.7 0.7 0.5 -0.0 0.2 0.6 0.7 0.4 0.7 0.6 1.0 0.5
Qualifications: nursing, teaching 0.4 0.7 2.9 0.9 -0.5 -0.3 1.7 -0.8 -0.8 -0.4 -0.1 -0.8 -1.2 -0.3 -0.7 -0.6 -0.7 -1.2 -1.0 -0.6 -0.2 -0.7 -1.1
Commuting to job workplace: Walk 0.2 0.2 1.0 0.3 0.1 0.1 1.0 -0.3 0.6 0.3 0.3 0.0 -0.4 0.1 -0.8 -0.1 0.1 -0.5 -0.4 0.0 0.2 0.1 -0.5
Eye problems/disorders: Cataract 0.9 1.0 1.6 0.9 -1.2 -1.1 -0.3 -1.0 -1.0 -1.1 -1.1 -1.1 -1.1 -1.3 0.8 -0.7 -1.1 -0.8 -0.3 -1.2 -1.3 -1.2 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.4 -1.4 0.5 0.3 -1.4 1.3 1.5 0.5 0.1 0.8 1.1 0.4 0.8 0.1 0.6 1.5 1.5 0.8 0.3 0.6 0.6
Medication for cholesterol 0.4 0.7 1.9 -0.4 0.7 0.5 -1.4 1.0 0.7 0.5 0.3 0.8 1.1 0.5 0.6 0.6 0.9 1.4 1.2 0.8 0.4 0.9 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.6 0.7 -0.6 -0.8 -0.9 -0.4 0.2 -0.5 -0.8 -0.3 -0.2 -0.7 1.3 -0.8 -0.4 0.2 -0.4 -0.4 -0.8 0.0 -0.3
Back pain experienced in last month 0.3 0.4 1.5 0.2 -0.5 -0.4 1.1 -1.0 -0.0 -0.3 -0.3 -0.7 -0.9 -0.3 -0.4 -0.6 -0.8 -1.2 -1.0 -0.5 -0.2 -0.2 -0.7
Mineral and other dietary supplements 0.9 1.2 2.8 1.4 -1.1 -1.0 -0.3 -1.2 -0.1 -1.1 -0.9 -1.1 -1.2 -1.2 0.6 -1.2 -1.0 -0.8 -1.7 -1.2 -1.1 -0.9 -1.5
Breast cancer (self-reported) 0.6 0.7 1.4 0.8 -0.9 -1.0 -1.0 -0.7 0.5 -0.9 -1.0 -0.7 -0.6 -0.9 1.1 -1.0 -0.8 -0.3 -0.9 -0.8 -0.9 0.1 -1.2
Asthma (self-reported) 0.6 1.2 2.5 0.1 -1.3 -1.3 -1.1 -0.8 0.4 -1.4 -1.3 -1.0 -0.9 -1.6 1.4 -1.3 -1.2 -0.4 -0.7 -1.4 -1.5 -0.7 -0.8
Osteoporosis (self-reported) 0.9 1.2 2.8 -0.5 1.1 0.9 -0.7 1.1 1.4 1.1 0.9 1.1 1.2 1.0 -0.3 0.8 1.2 1.3 1.1 1.2 1.0 1.7 1.1
Osteoarthritis (self-reported) 1.5 1.9 3.1 -1.6 1.5 1.5 0.5 1.4 0.7 1.6 1.6 1.4 1.4 1.5 -1.2 1.8 1.5 1.0 1.1 1.5 1.5 1.6 1.1
Medication: Aspirin 0.6 0.8 3.0 1.1 -0.6 -0.4 1.4 -1.0 -1.7 -0.3 -0.3 -0.9 -1.1 -0.3 -0.5 -0.4 -0.7 -1.4 -0.8 -0.7 -0.3 -1.2 -0.6
Medication: Gliclazide 0.4 0.5 2.5 -0.6 0.5 0.6 1.6 0.1 -0.1 0.8 0.8 0.3 -0.2 0.7 -1.4 1.0 0.0 -0.5 -0.4 0.4 0.7 0.1 -0.2
Illnesses of father: None of the above (group 1) 0.3 0.4 1.8 -1.3 0.5 0.3 -0.4 0.8 0.7 0.5 0.2 0.6 0.8 0.5 0.1 0.2 0.5 0.8 0.2 0.6 0.4 1.1 0.7
Smoking status: Current 0.2 0.3 3.7 -1.1 -0.2 -0.1 -0.5 0.1 1.9 -0.1 -0.1 0.0 -0.0 -0.3 0.3 -0.2 -0.0 0.4 0.2 -0.3 -0.3 -0.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 3.1 -0.1 1.3 1.2 1.5 0.7 -0.8 1.5 1.3 1.0 0.8 1.6 -1.8 1.6 1.1 0.0 0.7 1.2 1.5 1.3 1.0
Whole body water mass 0.3 1.6 4.5 -2.1 1.1 0.9 -1.0 1.7 2.1 0.9 0.8 1.3 1.5 0.8 0.1 1.0 1.2 1.5 1.7 1.0 0.8 1.3 1.1
Leg predicted mass (right) 0.4 1.9 6.9 -2.6 1.0 0.9 -1.2 1.8 2.5 0.8 0.7 1.3 1.6 0.7 0.2 0.9 1.2 1.7 1.6 1.0 0.7 1.4 1.3
Arm fat mass (left) 0.1 0.3 2.7 -1.1 0.4 0.5 0.4 0.5 1.7 0.3 0.5 0.4 0.3 0.4 -0.6 0.5 0.4 0.1 0.4 0.4 0.5 0.5 0.3
Number of self-reported non-cancer illnesses 0.1 0.1 0.4 -0.4 0.2 0.3 -0.2 0.4 0.4 -0.0 0.4 0.2 0.2 0.1 -0.0 0.3 0.3 0.5 0.6 0.2 0.2 0.5 0.3
Average weekly champagne plus white wine intake 2.0 2.7 8.0 2.8 -1.3 -1.2 1.9 -2.2 -1.7 -0.9 -1.0 -1.7 -2.0 -0.7 -0.6 -1.4 -1.7 -2.6 -1.7 -1.4 -0.8 -1.6 -1.5
Miserableness 0.1 0.2 1.2 0.1 -0.1 -0.3 -1.1 0.3 0.3 -0.2 -0.4 0.1 0.4 -0.1 0.8 -0.4 -0.0 0.7 1.0 0.1 -0.3 0.1 0.5
Guilty feelings 1.2 1.8 3.9 0.5 -1.5 -1.4 -0.1 -1.5 0.3 -1.5 -1.3 -1.6 -1.6 -1.4 0.9 -1.7 -1.5 -1.2 -1.2 -1.4 -1.3 -1.7 -2.0
Wears glasses or contact lenses 1.2 1.4 2.5 -0.4 1.3 1.4 0.6 1.0 1.1 1.5 1.5 1.3 1.0 1.3 -1.3 1.6 1.3 0.8 1.2 1.3 1.4 0.8 0.9
Ever taken oral contraceptive pill 3.5 3.9 6.6 -0.3 2.3 2.6 0.6 1.7 0.5 2.3 2.5 2.1 1.7 2.3 -2.3 2.3 2.2 1.2 2.1 2.2 2.4 1.8 1.9
Hearing aid user 0.2 0.3 1.6 0.1 -0.3 -0.5 -0.8 -0.2 1.2 -0.6 -0.6 -0.3 0.0 -0.4 1.0 -0.8 -0.2 0.1 -0.3 -0.2 -0.4 -0.2 -0.3
Mother’s age at death 2.0 2.5 3.6 1.6 -1.7 -1.8 -1.1 -1.5 0.5 -1.7 -1.9 -1.5 -1.3 -1.8 1.8 -1.9 -1.5 -1.0 -1.3 -1.7 -1.8 -1.5 -1.5
Financial situation satisfaction 6.9 8.6 11.2 -2.6 3.3 3.3 1.3 2.8 1.3 3.3 3.3 3.2 2.9 3.2 -2.7 3.4 3.2 2.3 2.8 3.2 3.3 3.3 2.7
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.6 -0.1 -0.5 -0.5 -0.6 -0.3 -0.2 -0.6 -0.6 -0.5 -0.3 -0.6 0.7 -0.6 -0.4 -0.0 -0.3 -0.5 -0.6 -0.3 -0.4
Commuting to job workplace: Public transport 0.3 0.3 0.9 0.3 -0.6 -0.3 -0.4 -0.2 -0.9 -0.9 -0.3 -0.4 -0.4 -1.0 0.5 -0.4 -0.3 -0.2 -0.4 -0.8 -0.7 -0.7 -0.5
Eye problems/disorders: Glaucoma 0.4 0.5 4.0 1.0 -0.2 -0.1 1.4 -0.6 -2.0 -0.1 -0.1 -0.3 -0.4 0.2 -0.6 -0.1 -0.3 -0.9 -0.7 -0.1 0.1 -0.8 0.5
Medication: Blood pressure 0.3 0.5 4.0 0.1 0.1 0.2 2.0 -0.5 -1.3 0.3 0.4 -0.3 -0.5 0.5 -1.3 0.1 -0.3 -0.9 -0.7 0.0 0.5 -0.4 0.0
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.2 -0.1 -0.8 -0.8 -0.1 -0.7 -0.7 -0.7 -0.8 -0.8 -0.7 -0.8 0.6 -0.7 -0.8 -0.7 -0.4 -0.8 -0.8 -1.1 -0.5
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.9 -0.3 0.9 1.0 1.7 0.4 -1.4 1.0 1.0 0.5 0.4 1.2 -1.5 1.0 0.6 -0.4 0.7 0.8 1.2 0.4 0.9
High cholesterol (Self-reported) 0.1 0.1 1.2 -0.2 0.1 0.1 1.1 -0.3 -0.1 0.1 0.2 -0.2 -0.4 0.2 -0.7 -0.1 -0.1 -0.5 -0.4 0.0 0.2 0.2 -0.4
Medication: Bendroflumethiazide 0.7 1.1 1.6 -1.1 1.2 1.2 0.3 1.1 0.3 1.0 1.3 1.1 1.0 1.2 -1.1 1.3 1.0 0.9 0.9 1.2 1.2 1.1 1.1
Medication: Paracetamol 0.2 0.3 1.4 -0.2 0.4 0.5 1.1 -0.1 0.6 0.7 0.6 0.3 -0.1 0.7 -1.2 0.9 0.2 -0.5 0.2 0.4 0.7 0.2 0.1
Medication: Lisinopril 0.2 0.3 1.5 0.3 0.4 0.6 1.2 0.1 0.7 0.4 0.6 0.2 -0.0 0.5 -1.1 0.4 0.2 -0.4 -0.1 0.3 0.6 -0.2 0.2
Medication: Atorvastatin 1.8 2.3 8.6 0.1 1.5 1.9 2.8 0.3 0.2 1.9 2.1 1.0 0.3 1.8 -2.9 1.9 1.1 -0.5 0.6 1.2 1.9 0.8 0.3
Illnesses of father: High blood pressure 0.2 0.2 0.8 -0.3 -0.5 -0.4 0.3 -0.5 0.1 -0.3 -0.3 -0.5 -0.6 -0.4 0.1 0.0 -0.6 -0.5 -0.3 -0.5 -0.4 -0.3 -0.9
Alcohol drinker status: Never 1.3 1.5 5.1 -2.3 1.2 1.0 -0.5 1.5 1.2 1.1 1.0 1.2 1.3 1.1 -0.4 0.8 1.0 1.2 1.8 1.3 1.0 1.3 1.2
Ever smoked 0.0 0.1 0.6 0.0 -0.0 0.2 0.3 -0.2 -0.0 0.0 0.3 0.1 -0.3 -0.2 -0.4 0.4 0.1 -0.1 -0.3 -0.2 0.0 -0.5 -0.8
Basal metabolic rate 0.2 1.2 4.1 -2.0 0.9 0.7 -0.8 1.4 2.0 0.7 0.6 1.1 1.2 0.6 0.0 0.9 1.0 1.2 1.4 0.8 0.7 1.1 0.9
Leg fat percentage (left) 0.4 1.5 3.7 0.5 -1.2 -1.1 1.3 -1.5 0.3 -1.0 -1.0 -1.4 -1.7 -1.0 -0.2 -0.8 -1.4 -1.9 -1.5 -1.3 -0.9 -1.7 -1.4
Arm fat-free mass (left) 0.1 0.5 2.1 -1.4 0.5 0.4 -0.6 0.9 1.4 0.4 0.3 0.6 0.8 0.3 0.0 0.6 0.6 0.6 1.0 0.4 0.3 0.6 0.5
Number of operations (self-reported) 0.3 0.4 1.3 1.1 -0.5 -0.5 0.6 -0.8 -0.5 -0.6 -0.3 -0.7 -0.8 -0.5 -0.1 -0.2 -0.5 -0.9 -0.9 -0.6 -0.4 -0.7 -0.8
Average weekly beer plus cider intake 0.7 1.0 1.8 -1.0 1.1 1.0 1.1 0.7 -0.1 1.3 1.2 0.8 0.6 1.3 -1.4 1.0 0.9 0.2 0.8 1.1 1.3 1.2 0.7
Irritability 0.1 0.1 0.7 0.1 0.2 0.4 0.7 0.1 -0.9 0.1 0.4 -0.0 -0.1 0.2 -0.7 -0.0 -0.1 -0.2 -0.1 0.1 0.3 -0.6 0.1
Risk taking 0.2 0.3 1.6 -0.5 -0.4 -0.4 1.0 -0.5 -1.3 -0.2 -0.4 -0.5 -0.6 -0.1 -0.2 -0.6 -0.8 -0.9 -0.6 -0.4 -0.2 -0.1 -0.1
Ever had prostate specific antigen (PSA) test 1.8 2.1 3.5 0.2 1.6 1.8 0.9 1.1 1.2 1.7 1.8 1.4 1.2 1.7 -1.7 1.9 1.4 0.7 1.5 1.6 1.8 1.2 1.3
Fractured/broken bones in last 5 years 3.5 4.5 6.5 -1.2 2.4 2.4 1.1 2.0 0.4 2.3 2.5 2.3 2.1 2.4 -2.1 2.0 2.5 1.6 2.0 2.3 2.5 2.5 2.5
Age started oral contraceptive pill 0.4 0.5 1.7 -0.4 -0.6 -0.7 -1.3 0.1 -0.6 -0.8 -0.8 -0.4 -0.1 -0.9 1.2 -0.6 -0.2 0.4 -0.0 -0.6 -0.8 -0.8 -0.3
Diastolic blood pressure, automated reading 0.2 0.8 1.4 -0.1 -1.0 -0.9 -0.8 -0.9 -0.1 -1.0 -1.0 -1.0 -0.8 -1.0 1.0 -0.7 -1.1 -0.4 -0.5 -0.9 -1.0 -1.0 -1.2
Ever depressed for a whole week 0.5 0.6 1.5 0.7 -0.8 -0.8 -0.6 -0.8 1.0 -0.8 -0.8 -0.7 -0.7 -0.7 0.7 -0.7 -0.7 -0.4 -0.8 -0.6 -0.7 -1.2 -0.9
Unable to work because of sickness or disability 0.5 0.7 2.1 -1.4 0.7 0.8 -0.3 0.9 1.3 0.7 0.8 0.8 0.7 0.6 -0.3 0.9 0.8 1.0 1.1 0.8 0.6 0.7 0.4
Commuting to job workplace: Cycle 0.6 0.7 1.7 -0.7 0.9 0.7 -0.2 1.0 -0.4 0.9 0.6 0.9 1.1 0.8 -0.1 0.6 0.9 1.0 1.1 1.0 0.7 1.3 1.3
Myopia 0.2 0.3 0.6 0.1 0.6 0.5 0.2 0.5 0.0 0.7 0.6 0.5 0.5 0.6 -0.5 0.6 0.6 0.5 0.5 0.6 0.5 0.8 0.4
Vascular/heart problems diagnosed by doctor 0.2 0.6 4.0 -0.7 0.1 -0.2 -2.0 0.8 0.7 -0.2 -0.4 0.4 0.9 -0.2 1.4 -0.3 0.4 1.3 0.6 0.2 -0.3 0.6 0.6
Cholesterol lowering medication 0.3 0.4 1.5 0.3 -0.5 -0.5 1.1 -0.7 -1.2 -0.3 -0.3 -0.7 -0.9 -0.2 -0.3 -0.5 -0.8 -1.1 -0.9 -0.5 -0.3 -0.4 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.6 0.5 0.8 0.8 0.9 0.3 -1.2 1.0 0.9 0.6 0.4 1.0 -1.3 1.1 0.7 -0.1 0.4 0.8 1.0 0.5 0.8
Pain experienced in last month 0.1 0.2 2.3 0.1 0.3 0.3 -0.1 0.4 -1.5 0.0 0.2 0.3 0.4 0.2 0.0 -0.2 0.4 0.5 0.3 0.3 0.2 0.3 0.7
Supplements: Calcium 0.6 0.7 1.3 -0.9 -1.0 -1.0 -0.4 -0.8 0.3 -0.8 -1.0 -0.9 -0.9 -0.9 0.8 -0.7 -0.9 -0.7 -0.4 -0.9 -0.9 -0.4 -1.1
Basal cell carcinoma (self-reported) 0.5 0.6 1.2 0.9 -0.8 -0.8 -0.2 -0.7 0.2 -1.1 -0.8 -0.8 -0.7 -0.9 0.6 -0.9 -0.6 -0.6 -0.7 -0.8 -0.8 -0.6 -0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.9 -0.5 -0.3 -0.2 1.4 -0.7 -0.9 -0.1 -0.1 -0.6 -0.7 -0.1 -0.5 -0.1 -0.4 -1.0 -0.7 -0.5 -0.1 -0.2 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.4 -0.1 -0.4 -0.6 -0.4 -0.3 -0.2 -0.3 -0.6 -0.4 -0.3 -0.2 0.6 -0.3 -0.4 -0.2 0.2 -0.3 -0.4 -0.1 -0.5
Heart disease (siblings) 0.2 0.3 1.6 0.5 -0.2 0.1 0.9 -0.6 -1.3 0.1 0.2 -0.4 -0.6 -0.1 -0.7 0.5 -0.3 -0.8 -0.1 -0.3 0.0 -0.6 -0.7
Alcohol drinker status: Previous 0.1 0.1 0.2 0.5 -0.2 -0.1 -0.1 -0.2 -0.1 -0.1 -0.0 -0.2 -0.4 -0.2 -0.1 0.4 -0.3 -0.3 -0.3 -0.2 -0.1 -0.2 -0.3
Pack years of smoking 0.8 1.2 2.0 0.1 -1.3 -1.3 -0.7 -0.9 -0.1 -1.1 -1.4 -1.2 -1.1 -1.3 1.4 -0.9 -1.3 -0.6 -0.7 -1.3 -1.4 -1.3 -1.3
Impedance of whole body 0.2 1.1 4.9 1.5 -0.8 -0.7 0.9 -1.2 -2.2 -0.8 -0.6 -1.0 -1.1 -0.6 0.1 -1.0 -0.9 -1.1 -1.7 -0.8 -0.6 -1.0 -0.4
Leg fat mass (left) 0.1 0.2 1.8 -0.8 -0.1 0.1 0.8 -0.1 1.3 -0.0 0.1 -0.1 -0.3 0.1 -0.6 0.2 -0.1 -0.6 -0.1 -0.1 0.2 -0.3 -0.2
Arm predicted mass (left) 0.1 0.6 2.7 -1.6 0.5 0.5 -0.6 1.0 1.4 0.5 0.4 0.7 0.8 0.4 0.0 0.7 0.6 0.7 1.2 0.5 0.4 0.6 0.5