TWAS hub - SPATA13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1200	0.0390	0.00160	0.021	0.001	0.051	0.038	0.062	0.00130	0.2400	6.7e-07	0.00002	4.6e-08
2	GTEx	Artery Tibial	0.1335	0.0466	0.00360	0.009	NA	0.000	NA	0.000	0.06200	NA	3.2e-01	NA	2.9e-01
3	GTEx	Colon Transverse	0.2360	0.0820	0.00780	0.052	NA	0.081	NA	0.105	0.00170	NA	1.1e-04	NA	1.1e-05
4	GTEx	Pancreas	0.3070	0.0860	0.00069	0.079	NA	0.057	NA	0.104	0.00032	NA	2.1e-03	NA	3.8e-05
5	GTEx	Skin Sun Exposed Lower leg	0.1920	0.0550	0.00044	-0.002	NA	-0.001	NA	-0.003	0.47000	NA	4.0e-01	NA	8.6e-01
6	METSIM	Adipose	0.0809	0.0271	0.00220	0.001	0.021	0.006	0.018	0.003	0.19000	0.0003	3.3e-02	0.00078	9.7e-02
7	TCGA	Pheochromocytoma and Paraganglioma	0.2830	0.0920	0.00240	-0.002	0.028	-0.003	NA	0.001	0.39000	0.0280	4.3e-01	NA	2.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Commuting to job workplace: Cycle	3.9	4.7	9.1	-2.3	0.2	-3.0	-2.4	-2.1	-2.2	-1.8
Hypothyroidism (self reported)	3.1	7.2	29.5	-1.4	0.0	-2.3	-1.9	-2.6	5.4	1.8
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.8	17.8	1.0	4.2	2.9	3.0	-0.7	0.7	3.2
Hypothyroidism/myxoedema (self-reported)	2.8	5.5	16.9	-1.4	0.6	-2.2	-1.9	-2.8	4.1	1.8
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	12.9	-3.6	-1.1	-2.2	-1.2	-0.7	-1.3	-0.6
Medication: Omeprazole	2.5	3.0	10.2	-3.2	-1.4	-2.0	-1.3	-1.1	-1.1	-1.0
Hearing difficulty/problems with background noise	2.3	3.7	8.7	-2.9	0.5	-2.1	-2.9	0.6	-1.1	-1.6
Rheumatoid Arthritis	2.2	3.0	5.7	2.1	0.6	1.2	2.4	-0.2	2.3	1.9
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.1	15.6	0.5	3.9	2.6	2.5	-1.0	0.4	2.3
Mineral and other dietary supplements	2.2	2.9	10.8	1.4	-0.6	2.4	3.3	0.4	-1.1	-0.6
Medication: Levothyroxine sodium	2.1	3.6	14.2	-0.6	2.0	-1.0	-0.8	-1.7	3.8	1.5
Fluid intelligence score	2.1	4.4	10.5	-3.2	0.0	-3.0	-3.2	0.9	-0.3	-0.8
Multivitamins +/- minerals	2.0	2.5	8.3	-1.5	0.8	-0.4	-1.7	0.5	2.9	1.7
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.6	0.4	2.1	1.9	2.1	-1.2	-0.3	1.4
Supplements: Vitamin C	2.0	2.4	5.1	-0.8	-1.5	-1.3	-2.3	-2.3	-1.2	-0.3
Number of operations (self-reported)	2.0	2.9	6.9	-1.3	1.5	-2.3	-2.6	1.2	0.7	-1.7
Type 2 Diabetes (T2D) (2012)	1.9	2.2	6.2	-0.2	0.5	1.5	0.9	2.4	2.5	-0.2
Wheeze or whistling in the chest in last year	1.9	3.3	6.6	1.1	2.4	2.2	2.6	0.4	1.1	1.8
Had menopause	1.8	2.2	5.3	-1.3	0.2	-1.8	-2.3	1.3	1.8	-0.7
Supplements: Fish oil (including cod liver oil)	1.8	2.4	7.8	-1.6	0.0	-2.0	-2.8	-0.8	1.0	-0.4
Vitamin and mineral supplements	1.7	2.2	6.3	1.1	0.0	1.5	2.5	0.9	-1.7	-1.5
Emphysema/chronic bronchitis	1.7	1.9	5.2	1.2	1.2	1.9	2.3	-0.2	1.3	0.3
Ever depressed for a whole week	1.7	2.1	5.4	2.3	0.3	0.8	1.6	-0.8	2.0	1.1
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	5.5	2.2	1.4	1.5	2.4	1.7	-0.1	-0.2
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	6.1	0.7	2.5	1.1	2.1	-0.7	-1.0	0.1
Heart disease (mother)	1.6	2.0	5.4	-2.1	0.2	-1.5	-2.3	-0.2	-1.2	-0.1
Mean Putamen Volume	1.5	1.7	3.9	2.0	-0.2	1.6	1.8	-0.0	-0.1	1.4
Medication: Co-codamol	1.5	1.7	4.2	2.0	0.2	1.3	2.0	0.2	1.0	1.0
Mouth/teeth dental problems	1.5	2.2	4.6	-1.2	-2.2	-1.7	-1.5	-1.6	0.7	1.3
Hearing aid user	1.5	1.7	4.5	0.8	-1.7	0.3	0.4	2.1	1.7	-0.9
Heel T-Score	1.4	10.9	26.8	1.8	4.5	5.2	4.7	-0.4	-0.4	1.9
Hearing difficulty/problems: Yes	1.4	2.2	8.2	-2.9	-0.9	-1.2	-1.2	1.1	-0.7	-1.3
Supplements: Glucosamine	1.4	1.8	5.4	-0.9	-0.5	-2.1	-2.3	-0.9	-0.9	0.4
Hair/balding pattern: Pattern 2	1.4	1.8	3.4	-1.3	-0.9	-1.7	-1.8	-1.6	-0.6	-0.7
Supplements: Calcium	1.4	1.5	4.9	0.4	0.5	-1.8	-2.2	1.0	-0.5	1.1
Qualifications: CSEs or equivalent	1.3	1.7	4.6	1.2	0.1	2.2	2.0	0.8	-0.5	0.9
Medication: Ramipril	1.3	1.6	3.2	0.5	1.6	1.4	1.8	0.6	1.6	0.5
Father’s age at death	1.3	1.8	5.7	-0.6	-1.1	-2.1	-2.4	-0.3	0.6	-0.3
Breastfed as a baby	1.3	1.7	3.5	1.3	-1.6	1.9	0.7	1.1	1.5	0.2
Fractured/broken bones in last 5 years	1.3	1.7	4.1	-0.4	2.0	-0.7	-1.1	1.6	-1.6	-1.0
Hair/balding pattern: Pattern 3	1.2	1.7	3.5	1.3	-1.1	1.9	1.6	1.3	1.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.7	0.6	2.2	1.5	1.4	0.8	0.7	-0.7
High blood pressure (siblings)	1.2	1.8	3.6	-1.2	-1.1	-1.6	-1.9	-1.5	-0.6	-1.0
Worry too long after embarrassment	1.2	2.1	5.1	0.7	1.1	0.5	0.7	-2.2	-1.5	2.2
Shortness of breath walking on level ground	1.2	1.5	8.2	-0.8	-2.9	-0.8	-0.5	-0.1	-0.3	-0.5
Eye problems/disorders: None of the above	1.2	1.4	4.4	0.2	-0.3	2.1	2.0	-0.1	0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	5.9	0.9	0.5	2.0	2.4	-1.3	-2.1	0.4
Ever taken oral contraceptive pill	1.2	1.3	4.3	0.8	-0.5	1.6	2.1	-0.5	-0.6	-0.8
Chronic bronchitis/emphysema (father)	1.1	1.2	4.9	0.4	-1.5	-0.1	-0.3	0.9	0.7	-2.2
Lung cancer (father)	1.1	1.3	2.6	-1.6	0.3	-0.8	-0.3	-1.5	-1.6	-0.9
Had major operations	1.1	1.3	2.5	0.6	1.2	-1.6	-1.6	1.0	1.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	5.4	-0.0	-0.6	0.7	0.3	0.7	-2.3	-1.0
Qualifications: nursing, teaching	1.1	1.7	5.9	-0.2	0.4	-1.2	-0.5	1.6	-2.4	-1.2
Asthma (self-reported)	1.1	2.1	5.0	0.4	2.2	1.3	1.9	1.6	0.4	1.4
Ever smoked	1.1	2.0	6.7	-0.3	-1.3	-1.8	-2.6	-1.3	-0.2	-0.6
Basal cell carcinoma (self-reported)	1.1	1.3	3.4	-1.0	-1.1	-1.7	-1.8	0.2	-0.7	-0.4
Alzheimer’s Disease (in father)	1.0	1.0	3.5	-1.2	0.3	-1.3	-1.9	0.0	0.6	0.4
Fasting Glucose	1.0	1.3	4.2	-0.6	-2.1	-1.5	-0.8	0.4	-0.2	-1.1
Triglycerides	1.0	1.6	3.1	1.1	-1.4	1.8	1.4	1.6	0.9	-0.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.4	1.3	0.5	1.4	1.8	0.1	-0.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.1	-1.5	0.9	-1.1	-1.1	-1.8	-0.6	-0.4
Osteoarthritis (self-reported)	1.0	1.3	6.3	2.5	0.5	0.8	0.2	0.6	0.7	0.8
Pack years of smoking	1.0	1.4	4.2	1.1	-0.0	1.3	1.3	1.0	2.0	-0.5
Alzheimer’s Disease (including proxy)	0.9	1.3	2.3	-1.0	1.5	-1.4	-1.5	-0.9	0.8	0.5
Lupus	0.9	1.3	4.5	1.0	-0.9	1.3	1.2	-0.1	2.1	0.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	5.9	-0.4	2.4	-0.4	-0.8	0.9	-0.4	-0.7
Angina	0.9	1.1	4.9	-0.1	-0.6	1.4	0.1	2.2	0.8	-0.3
Pack years adult smoking proportion	0.9	1.4	3.1	1.3	0.2	1.5	1.5	0.8	1.8	-0.2
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.4	0.2	1.9	-0.0	0.4	2.3	0.6	2.1
Medication: Atenolol	0.9	1.2	3.9	-0.3	-0.0	0.7	1.2	-0.4	1.5	2.0
Alcohol usually taken with meals	0.9	1.4	4.6	-0.6	-0.5	-2.1	-2.0	0.4	-0.4	-0.6
Asthma	0.9	1.8	5.1	0.2	2.3	0.8	1.6	1.4	0.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.2	1.5	0.2	0.9	1.0	0.9	-1.1	-1.0
Pulse wave peak to peak time	0.9	1.0	4.8	0.1	-2.2	-0.4	0.1	0.9	-1.0	0.6
Medication: Seretide 50 evohaler	0.9	1.1	5.4	-0.6	2.3	-0.6	-0.9	0.7	0.4	-0.2
Number of full sisters	0.9	1.2	5.3	0.9	-0.3	-0.3	-0.5	1.1	2.3	0.5
Leg pain on walking	0.9	1.1	5.2	-0.4	-2.3	-0.5	-0.8	0.6	1.2	0.1
Illnesses of father: Heart disease	0.9	1.3	3.8	-1.3	-0.1	1.4	0.5	1.1	0.2	-2.0
Alcohol drinker status: Never	0.9	1.1	4.4	-2.1	0.7	-1.5	-0.6	0.3	0.2	-0.4
Myopia	0.9	1.4	2.4	0.3	0.9	1.1	1.1	1.3	1.4	1.5
Verbal and Numeric Reasoning (VNR)	0.8	1.8	5.7	-1.6	0.2	-2.0	-2.4	0.8	0.2	0.2
Coronary Artery Disease (CAD)	0.8	0.9	1.9	-1.4	-0.5	-1.4	-0.9	-1.3	-0.1	-0.0
Blood Platelet Count	0.8	9.6	21.8	4.0	1.8	4.7	4.5	1.9	-1.3	-0.5
Allergy or Eczema	0.8	2.1	7.6	0.7	0.8	0.0	0.6	2.8	1.4	1.8
Ever had hysterectomy (womb removed)	0.8	0.9	3.2	0.5	1.8	0.1	-0.2	1.4	0.6	-0.9
Diabetes (father)	0.8	1.0	2.7	0.2	0.2	0.6	1.7	0.7	0.8	1.5
Average weekly fortified wine intake	0.8	0.9	2.2	-0.2	0.8	1.5	0.9	0.3	1.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.7	-0.2	0.2	0.8	1.7	1.4	-0.8	0.7
Pulse wave Arterial Stiffness index	0.8	0.9	4.1	-0.2	2.0	0.4	0.0	-0.8	0.8	-0.8
Hair/balding pattern: Pattern 4	0.8	1.9	8.2	0.1	2.9	0.1	-0.8	-1.7	-1.0	0.6
Headache pain in last month	0.8	1.4	4.8	0.1	1.6	1.5	2.2	-0.1	-0.1	0.0
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.0	0.7	0.4	1.2	0.9	0.3	-1.2	1.7
Family relationship satisfaction	0.8	1.0	4.1	0.2	0.6	-0.7	-0.7	-2.0	1.3	0.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.7	-1.1	0.2	-0.2	-0.4	-1.9	-0.9	0.9
Loneliness, isolation	0.8	1.1	3.2	-0.8	1.3	0.5	-0.4	-0.1	1.8	1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	7.6	-0.2	0.9	0.2	-0.1	2.8	0.5	0.2
Illnesses of father: None of the above (group 1)	0.8	0.9	2.0	1.3	-0.2	-0.8	-0.4	-1.4	-0.5	1.3
Commuting to job workplace: Public transport	0.8	0.9	1.9	-0.2	-1.3	-0.7	-1.4	-1.1	1.1	0.2
Medication: Lisinopril	0.8	1.1	2.8	-0.9	0.9	-0.7	-1.5	0.2	-0.4	-1.7
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	-0.7	0.7	-1.2	-1.0	-0.9	0.4	1.1
Respiratory disease	0.7	1.6	4.7	0.5	1.2	1.6	2.2	1.0	0.7	0.7
Fed-up feelings	0.7	1.2	3.8	0.3	1.9	0.3	-0.1	1.7	1.2	0.2
Stomach or abdominal pain in last month	0.7	0.9	3.9	-0.4	-0.6	0.8	2.0	1.0	0.4	-0.4
High blood pressure (mother)	0.7	1.0	4.1	1.0	-0.2	1.0	0.6	0.4	-0.6	-2.0
Had other major operations	0.7	0.8	2.5	-0.1	-0.7	0.0	-0.1	1.2	1.1	-1.6
Allergy	0.7	1.7	4.9	0.2	-2.2	-0.3	-1.3	-1.2	-0.5	-1.8
Pain all over the body in last month	0.7	0.8	2.6	-0.9	0.7	-0.5	-0.9	1.6	0.4	-0.4
Diabetes (self-reported)	0.7	1.1	4.2	-0.7	0.6	-0.4	-1.1	0.0	-2.1	-1.0
Illnesses of siblings	0.7	0.9	2.5	0.5	1.0	1.1	1.6	0.7	0.2	1.1
Alcohol intake versus 10 years previously	0.7	1.0	4.3	0.7	-0.6	0.6	-0.4	0.4	2.1	1.0
Falls in the last year	0.7	1.0	1.9	1.2	1.3	1.3	1.4	0.1	-0.6	-0.2
Depression (self-reported)	0.7	0.8	4.2	-0.2	0.7	-0.5	-0.7	-2.0	-0.5	-0.4
Migraine (self-reported)	0.7	0.9	1.8	-0.5	-0.6	0.7	1.3	0.5	-1.2	1.2
Medication: Ibuprofen	0.7	0.9	1.8	1.0	1.3	0.9	1.1	0.0	-0.6	-1.1
Medication: Aspirin	0.7	1.0	3.0	0.1	0.2	0.0	-0.6	-1.7	-0.9	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.4	1.5	0.4	0.9	0.9	1.1	-0.3	0.1
Smoking status: Previous	0.7	1.1	3.4	0.4	0.1	-1.0	-1.8	-1.8	0.4	0.0
Eye problems/disorders: Cataract	0.7	0.9	2.7	0.2	0.7	-1.6	-1.3	-0.4	0.8	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.4	-0.6	-0.1	0.8	0.3	1.5	1.4	-0.2
Medication: Gliclazide	0.7	0.8	3.5	-0.8	0.6	0.2	0.5	-0.9	-1.9	0.2
Wears glasses or contact lenses	0.7	0.8	2.6	1.1	1.6	0.3	0.8	0.7	0.8	-0.2
Financial situation satisfaction	0.7	0.9	5.4	-0.5	0.4	-0.2	0.3	-2.3	0.3	0.5
Unable to work because of sickness or disability	0.7	1.0	3.3	0.1	-0.9	-0.7	-0.1	1.1	-1.0	-1.8
Schizophrenia vs Biploar Disorder	0.6	0.8	1.9	0.4	-1.2	0.4	0.5	0.8	-1.4	-1.0
Breast Cancer	0.6	1.5	4.9	-1.8	-0.2	-1.0	-0.6	2.2	0.7	0.6
Prostate Cancer	0.6	0.9	2.5	1.3	0.2	0.6	0.6	-1.6	-0.1	-1.1
Age at First Birth	0.6	0.9	2.6	1.6	-0.5	1.2	1.1	0.3	-1.0	-0.5
HbA1C	0.6	0.6	1.8	0.6	0.3	1.0	0.7	0.6	1.3	-0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.5	-1.7	0.2	-0.6	-1.2	0.4	-1.9	0.2
Average weekly spirits intake	0.6	0.7	1.2	0.1	-1.1	-0.1	1.0	1.1	-0.9	-0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.5	-0.5	0.0	-0.1	-0.7	1.9	0.3	-0.6
Taking other prescription medications	0.6	0.9	3.5	-1.4	1.9	-0.2	-0.5	0.2	0.5	0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.8	0.1	0.6	1.1	1.4	0.0	-0.4	0.8
Past tobacco smoking	0.6	1.0	3.6	-0.1	0.3	0.9	1.9	1.5	-0.5	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.0	0.2	0.2	0.0	0.6	-1.4	1.4	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.2	0.3	1.2	1.4	1.8	0.6	0.2	-0.5
Number of live births	0.6	0.9	2.9	-1.2	-1.1	-0.4	-0.4	0.1	-0.1	1.7
Mouth/teeth dental problems: Dentures	0.6	1.0	2.6	1.3	-0.1	0.8	-0.0	1.1	-0.7	-1.6
Medication: Lansoprazole	0.6	0.7	2.1	0.5	1.4	0.6	-0.4	-0.3	-0.5	-1.2
Prospective memory result	0.6	0.7	1.8	0.3	0.7	0.2	1.1	-1.2	-1.3	-0.0
Length of working week for main job	0.6	0.7	1.9	-0.4	0.9	0.2	0.4	1.4	-0.3	1.4
Birth weight of first child	0.6	1.1	3.6	-1.3	-0.1	-0.6	-1.2	-1.9	-0.9	-0.2
Angina (self-reported)	0.6	0.8	3.2	-0.2	-0.7	0.8	-0.5	1.8	0.8	-0.6
Chest pain or discomfort	0.6	0.8	3.4	-1.0	0.3	-0.3	0.2	-0.2	-1.8	-1.1
Ever had bowel cancer screening	0.6	0.7	2.7	0.3	0.1	-0.8	-1.2	0.0	0.2	-1.6
Back pain experienced in last month	0.6	0.9	1.8	1.3	0.4	1.4	1.2	0.2	-0.9	0.5
Breast cancer (self-reported)	0.6	0.7	2.6	0.2	-1.6	0.3	0.1	-1.4	-0.3	-0.4
Medication: Aspirin	0.6	0.7	2.1	-0.1	0.0	-0.1	-0.6	-1.2	-1.0	-1.5
Illnesses of father: High blood pressure	0.6	0.8	3.0	-0.7	-0.3	0.7	0.5	-0.2	1.7	1.0
Risk taking	0.6	0.9	2.7	1.6	0.8	0.6	0.5	1.2	-0.6	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.5	0.8	0.8	1.1	0.8	-0.1	0.6	-1.2
Ulcerative Colitis (UC)	0.5	1.0	4.7	-1.2	0.5	-0.2	0.6	0.2	-0.1	2.2
Bipolar Disorder (2011)	0.5	0.5	2.6	-0.5	0.1	0.0	-0.6	-0.3	-0.2	-1.6
Primary Biliary Cirrhosis	0.5	0.7	4.2	-0.4	-0.4	-0.3	0.3	0.6	-2.0	-0.3
Lung FVC	0.5	2.4	6.4	2.0	-0.4	2.5	2.2	-0.0	-1.3	0.0
Supplements: Zinc	0.5	0.6	1.3	-0.7	-1.0	-0.1	-1.1	0.2	0.1	1.0
Relative age voice broke	0.5	0.8	3.0	0.3	1.7	-1.0	-0.9	0.4	-0.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	0.2	-1.3	-0.5	-0.1	-0.9	-0.9	-0.7
Sitting height	0.5	3.5	13.7	0.6	0.5	2.8	3.7	-0.6	0.8	1.1
Qualifications: None of the above	0.5	1.0	3.3	-1.8	-0.7	-0.7	-0.9	0.0	1.5	0.2
Heart attack	0.5	0.6	1.3	0.7	0.8	1.1	0.6	-0.2	0.7	-1.1
Pulse rate	0.5	0.9	3.0	-0.2	0.2	-1.3	-1.2	-1.7	0.2	-0.4
Happiness	0.5	0.6	1.3	1.1	1.0	0.6	0.7	-0.7	0.2	0.6
Pulse wave reflection index	0.5	0.6	2.6	-0.1	1.6	0.6	0.5	-0.4	-1.0	-0.2
Blood clot in the leg (DVT)	0.5	0.7	2.7	-1.1	-0.6	-0.5	0.2	0.4	-0.1	-1.7
Number of children fathered	0.5	0.6	3.2	0.7	1.8	0.3	-0.1	0.1	-0.2	-0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	0.5	1.0	0.6	1.0	-0.6	-1.1	-0.1
Mood swings	0.5	1.0	2.6	1.4	0.9	0.7	0.8	1.6	0.3	0.1
Long-standing illness, disability or infirmity	0.5	0.7	2.0	-0.8	0.3	-0.5	-1.2	-1.4	-0.5	-0.5
Osteoporosis (self-reported)	0.5	0.6	2.5	0.2	0.0	0.1	-0.3	0.6	-1.2	1.6
Average weekly champagne plus white wine intake	0.5	0.6	1.7	0.4	1.3	0.5	1.0	-0.1	0.0	1.1
Medication: Paracetamol	0.5	0.8	2.1	1.4	-1.1	0.8	0.9	-0.0	-0.9	-0.1
Medication: Atorvastatin	0.5	0.6	2.1	-1.4	0.3	0.3	-0.1	1.2	0.8	0.0
Age started oral contraceptive pill	0.5	0.7	1.2	-0.8	-0.7	-1.1	-0.9	0.0	0.9	-0.9
Diastolic blood pressure, automated reading	0.5	1.6	6.1	0.6	-0.8	-0.9	-0.6	-2.5	1.7	0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.1	-1.4	-0.3	-0.6	0.2	0.6	0.1	-1.4
Heart disease (siblings)	0.5	0.7	2.6	-0.2	0.3	0.8	-0.1	0.1	-1.6	-1.1
Irritable Bowel Disease (IBD)	0.4	0.9	5.6	-0.3	-0.2	0.2	0.6	-0.1	0.2	2.4
Reaction Time	0.4	0.7	2.8	0.3	-1.7	0.2	0.2	0.4	1.2	-0.4
Neuroticism (2016)	0.4	0.5	1.5	-1.1	-0.4	-0.5	-0.3	-1.2	0.1	0.6
Cardiovascular Disease	0.4	1.3	4.2	0.6	0.3	2.0	1.8	0.8	0.6	0.7
Hand grip strength (left)	0.4	1.0	2.6	-0.1	1.0	1.5	1.6	-0.6	-0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	-0.7	1.1	-0.4	-0.1	0.3	-0.2	-1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.3	-0.5	-0.0	-0.4	-1.5	0.2	0.3	0.6
Systolic blood pressure, automated reading	0.4	1.3	3.4	-0.0	-0.7	-1.1	-1.5	-0.9	1.8	-0.8
Medication: Metformin	0.4	0.5	1.3	-0.8	-0.4	-0.2	-0.3	1.1	-1.1	-0.7
Severe depression (siblings)	0.4	0.5	1.1	1.0	-1.0	0.5	-0.1	-0.8	-0.2	-0.7
Age when periods started (menarche)	0.4	1.0	3.3	-0.0	-1.8	-0.9	-1.5	0.1	-0.8	0.1
Serious illness, injury or assault to yourself	0.4	0.5	2.6	0.4	1.6	0.6	0.5	-0.1	-0.3	0.4
Financial difficulties in last 2 years	0.4	0.5	1.6	-0.4	1.3	0.1	0.6	-0.7	-0.8	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-1.0	0.4	-0.5	-0.6	-0.6	-0.9	0.7
Time employed in main current job	0.4	0.5	1.4	0.8	0.3	0.1	-0.4	-0.7	-0.9	-1.2
Medication: Cholesterol lowering	0.4	0.6	1.7	0.1	-0.3	1.3	1.0	1.0	0.0	0.4
Illnesses of mother	0.4	0.5	1.0	-0.9	-0.7	-1.0	-0.8	0.5	0.6	0.3
Tense / ‘highly strung’	0.4	0.6	3.1	0.3	0.0	0.5	0.4	1.8	0.7	-0.2
Peak expiratory flow (PEF)	0.4	0.9	2.4	0.9	-0.3	1.6	1.4	-0.1	-0.2	1.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	0.2	-0.6	0.8	0.4	-1.1	0.5	0.8
Loud music exposure frequency	0.4	0.5	1.3	0.4	-0.0	-0.4	-1.1	-0.4	-1.1	0.5
Gout (self-reported)	0.4	0.5	0.9	0.3	-0.7	0.4	-0.2	-1.0	0.9	0.9
Medication: Amlodipine	0.4	0.6	3.4	-0.1	1.8	0.4	0.2	0.7	0.4	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-0.6	-0.6	0.0	0.1	1.2	0.9	0.7
Alcohol intake frequency.	0.4	0.9	2.1	-1.1	1.4	0.1	-0.4	0.2	0.9	-1.4
Friendships satisfaction	0.4	0.4	2.1	0.4	0.6	0.3	-0.5	-0.4	1.4	0.3
Smoking status: Current	0.4	0.6	1.9	-0.4	0.2	1.0	0.6	0.5	-0.3	1.4
Miserableness	0.4	0.7	2.8	0.9	1.7	0.6	0.5	-0.3	0.6	0.7
Guilty feelings	0.4	0.6	1.6	-0.4	1.3	0.4	0.3	-0.6	-0.0	1.2
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.6	0.3	0.1	-0.8	-0.4	0.3	-0.5	-1.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.4	-1.4	-0.8	-1.3	-0.1	-0.9	-1.8	0.4
Depression (Nagel 2018)	0.3	0.5	2.9	-0.1	0.2	-0.3	0.2	0.3	-0.7	-1.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	-0.9	0.4	-0.3	-0.9	1.5	-0.4	-1.5
Ovarian Cancer	0.3	0.4	2.0	0.7	0.2	-0.3	-0.1	-0.1	1.4	-0.1
Ulcerative Colitis	0.3	0.4	2.5	-0.3	1.6	-0.3	0.2	-0.2	0.0	0.5
Blood White Count	0.3	2.6	7.5	1.0	-2.2	1.1	1.4	-0.3	-1.1	2.7
Lung FEV1/FVC ratio	0.3	1.5	4.8	-1.6	-0.1	-0.5	-0.7	1.0	2.2	1.1
Sensitivity / hurt feelings	0.3	0.5	1.6	0.4	0.7	0.5	0.6	-1.3	0.2	0.9
Hand grip strength (right)	0.3	0.7	2.4	-0.5	0.6	0.8	1.5	-1.1	-0.4	-0.3
Townsend deprivation index at recruitment	0.3	0.4	2.0	0.8	0.3	-0.1	0.3	0.3	1.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-1.1	0.5	0.5	0.6	0.4	0.4	-0.8
High blood pressure	0.3	0.9	3.6	1.0	0.6	0.8	-0.3	0.5	1.9	-0.4
Nervous feelings	0.3	0.5	1.1	-0.7	-0.4	0.4	0.0	1.1	1.0	0.8
Forced vital capacity (FVC)	0.3	1.3	3.5	0.7	0.2	1.7	1.9	-0.6	-0.9	1.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.0	0.2	-0.3	1.6	1.7	-0.4	-0.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.1	0.7	0.8	0.8	0.2	0.9	0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.8	0.0	0.2	-0.9	-0.7	-1.3	-0.2	0.3
Birth weight	0.3	0.7	3.9	-0.2	2.0	0.1	-0.1	-0.2	0.0	0.7
Forced vital capacity (FVC), Best measure	0.3	1.0	2.4	1.2	0.0	1.3	0.9	-1.6	-0.5	1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.8	0.0	-0.1	0.5	-0.3	0.7	1.3	0.7
Comparative body size at age 10	0.3	0.7	1.8	-1.4	-0.2	0.2	-0.8	-0.3	-0.8	-1.3
Number of full brothers	0.3	0.4	1.7	1.3	0.1	0.6	0.5	-0.2	-0.6	-0.2
Qualifications: College or University degree	0.3	0.8	3.0	-0.8	0.2	-1.7	-1.1	0.4	-0.8	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	0.5	-0.4	-0.5	-0.4	0.3	1.0	1.2
Medication: Blood pressure	0.3	0.5	1.2	0.3	0.6	1.0	0.4	1.1	0.3	-0.5
Pulse rate, automated reading	0.3	0.9	2.8	1.0	1.7	-0.3	-0.9	-0.7	0.8	0.4
Comparative height size at age 10	0.3	1.8	5.4	-2.3	-1.1	-0.9	-0.8	-1.2	-0.9	-1.5
Overall health rating	0.3	0.6	1.9	-1.4	0.3	0.2	-0.3	-0.4	1.2	-0.6
Knee pain experienced in last month	0.3	0.5	2.2	-0.4	-1.5	0.3	0.3	-0.8	0.0	0.6
Hypertension (Self-reported)	0.3	0.8	3.3	1.2	0.6	0.8	-0.2	0.4	1.8	-0.2
Average weekly red wine intake	0.3	0.4	0.8	-0.3	0.9	-0.5	-0.9	-0.5	-0.7	-0.1
Diabetes diagnosed by doctor	0.3	0.5	1.4	-0.6	0.6	0.0	-1.0	0.4	-1.2	-0.3
Commuting to job workplace: Walk	0.3	0.4	1.3	0.1	0.1	-0.6	-0.2	-0.8	0.3	-1.1
Medication for cholesterol	0.3	0.4	1.0	-0.4	-0.7	-1.0	0.1	0.2	-0.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-0.6	-0.6	-1.1	-1.1	-1.1	-0.1	-0.1
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	-0.5	1.0	0.7	0.7	1.1	-0.1	-0.2
Mother’s age at death	0.3	0.3	0.7	-0.7	0.1	-0.4	-0.5	0.8	0.7	-0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.6	-0.9	-0.0	0.3	-0.1	-1.3	0.1	-0.6
Average weekly beer plus cider intake	0.3	0.4	0.8	0.8	0.8	0.7	0.2	-0.9	-0.2	0.3
Alcohol drinker status: Previous	0.3	0.4	1.2	-0.5	1.1	0.3	0.2	0.0	-1.0	-0.1
Bipolar Disorder (2018)	0.2	0.3	0.9	-0.3	0.9	-0.6	-0.1	-0.3	0.3	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	-0.2	0.9	0.3	0.4	-1.0	0.7	-0.4
Depressed Affect (Nagel 2018)	0.2	0.5	2.2	0.5	1.5	0.2	0.2	0.9	0.4	0.1
Neuroticism (Nagel 2018)	0.2	0.5	1.3	0.7	0.5	0.8	0.7	0.4	0.4	1.1
Schizophrenia (2018)	0.2	0.4	1.0	-0.1	0.7	1.0	0.6	-0.8	0.7	-0.0
Crohns Disease (2017)	0.2	0.4	1.4	0.1	-1.2	0.0	0.1	-0.5	-0.3	1.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.7	0.1	-1.3	0.3	0.3	0.5	-0.0	0.3
Blood Red Count	0.2	1.5	4.2	2.0	1.1	1.3	1.5	0.4	0.8	0.0
Systolic Blood Pressure	0.2	0.8	2.8	-0.5	-0.5	-0.2	-0.1	-1.7	1.2	0.8
Smoking Status	0.2	0.5	1.5	0.5	-0.1	0.6	-0.2	-1.2	-0.3	1.2
Chronotype (morning person)	0.2	0.5	1.3	1.2	-0.3	0.0	0.5	0.0	-1.0	-1.1
Number of treatments/medications taken	0.2	0.4	2.5	-0.5	1.6	0.4	0.0	-0.2	-0.2	0.3
Relative age of first facial hair	0.2	0.5	1.3	-0.2	1.1	-0.8	-1.1	0.4	0.3	-0.2
Medication for hormone replacement therapy	0.2	0.3	1.1	-0.7	1.0	0.2	-0.3	-0.2	0.1	0.2
Impedance of leg (right)	0.2	1.1	5.0	1.1	-0.9	-0.1	0.5	2.2	-0.4	-0.6
Leg fat-free mass (left)	0.2	0.9	3.1	0.1	0.5	1.2	0.7	-1.8	0.8	-0.3
Current tobacco smoking	0.2	0.4	0.9	-0.1	-0.1	0.9	0.7	0.3	-0.7	1.0
Maternal smoking around birth	0.2	0.3	1.0	-0.2	-0.3	0.6	-0.4	-0.5	-1.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.2	-0.0	-1.1	0.1	0.5	0.5	0.1	-0.5
Impedance of leg (left)	0.2	0.9	2.5	0.9	-0.8	-0.5	0.4	1.6	-1.2	-0.4
Leg predicted mass (left)	0.2	0.9	3.1	0.1	0.6	1.3	0.7	-1.7	0.8	-0.2
Waist circumference	0.2	0.9	2.0	-0.1	1.3	-0.2	-1.2	-1.4	0.8	-0.5
Number of incorrect matches in round	0.2	0.3	0.6	-0.6	-0.2	0.7	0.6	0.6	-0.8	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.9	0.6	-0.2	0.2	0.5	-0.5	-0.6
Medication: Simvastatin	0.2	0.3	0.6	0.7	-0.5	0.8	0.4	0.4	0.2	-0.3
Impedance of arm (right)	0.2	0.8	1.9	0.6	-1.0	-1.4	-0.3	1.3	0.1	-0.5
Trunk fat-free mass	0.2	1.2	3.7	-0.5	1.3	1.3	0.6	-1.9	0.6	-0.4
Noisy workplace	0.2	0.2	0.7	-0.3	0.6	0.4	0.2	-0.5	0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-0.2	1.0	-0.4	0.1	1.1	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	0.3	-0.5	0.8	0.6	-1.2	-0.2	1.1
Impedance of arm (left)	0.2	1.0	4.0	0.8	-2.0	-1.0	0.4	1.1	-0.2	0.1
Trunk predicted mass	0.2	1.1	3.6	-0.5	1.3	1.2	0.5	-1.9	0.5	-0.3
Exposure to tobacco smoke at home	0.2	0.3	1.1	-0.1	0.6	0.1	0.4	0.6	-1.0	0.0
Medication: Paracetamol	0.2	0.4	0.7	0.7	-0.8	0.8	0.8	-0.0	-0.6	0.3
Arm fat-free mass (right)	0.2	0.9	4.4	-0.4	0.5	1.1	0.6	-2.1	0.4	-0.2
Health satisfaction	0.2	0.2	0.9	0.0	-1.0	-0.1	0.2	-0.7	-0.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.2	-0.5	-0.8	0.5	0.5	-0.7	0.2
Neck or shoulder pain in last month	0.2	0.3	1.1	-0.2	-0.2	-0.3	-0.4	-1.0	-0.2	-0.7
Medication: Allopurinol	0.2	0.2	0.5	-0.3	-0.5	-0.5	-0.7	-0.1	0.4	-0.4
Arm predicted mass (right)	0.2	0.9	4.5	-0.4	0.3	1.1	0.6	-2.1	0.1	-0.3
Suffer from ‘nerves’	0.2	0.4	1.2	-0.9	-0.2	0.1	0.5	0.1	0.4	1.1
Age at last live birth	0.2	0.4	1.8	0.0	-0.8	0.2	-0.0	-0.2	0.1	1.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.2	0.1	-0.4	-0.6	-1.1	0.2	-0.4	-0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.3	0.6	-0.4	-0.3	-0.2	-0.6	0.8
Whole body fat-free mass	0.2	1.1	4.2	-0.3	0.9	1.3	0.6	-2.0	0.6	-0.3
Leg fat-free mass (right)	0.2	0.9	4.7	-0.1	0.6	1.0	0.6	-2.2	0.4	-0.1
Whole body water mass	0.2	1.1	4.4	-0.4	1.0	1.2	0.5	-2.1	0.4	-0.3
Leg predicted mass (right)	0.2	1.0	4.7	0.0	0.5	1.0	0.6	-2.2	0.5	-0.1
Medication: Blood pressure	0.2	0.5	2.2	-0.1	0.4	0.6	-0.1	0.0	1.5	-0.7
High cholesterol (Self-reported)	0.2	0.4	1.4	-0.1	-0.8	0.9	1.2	-0.4	-0.2	-0.2
Medication: Bendroflumethiazide	0.2	0.2	0.8	0.4	0.5	0.9	0.1	0.7	0.2	-0.0
Basal metabolic rate	0.2	0.9	3.8	-0.2	1.0	1.1	0.5	-2.0	0.5	-0.3
Arm fat-free mass (left)	0.2	0.8	2.5	-0.5	1.3	1.0	0.1	-1.6	0.3	-0.3
Cholesterol lowering medication	0.2	0.2	0.6	0.4	-0.6	0.1	-0.1	0.6	0.5	-0.8
Pain experienced in last month	0.2	0.4	1.1	0.1	1.0	-0.4	-1.1	0.6	-0.4	0.3
Impedance of whole body	0.2	1.0	2.7	1.1	-1.4	-0.7	0.6	1.6	-0.3	0.2
Arm predicted mass (left)	0.2	0.9	3.2	-0.4	1.3	1.0	0.3	-1.8	0.0	-0.4
Worry (Nagel 2018)	0.1	0.1	0.3	-0.6	-0.6	-0.3	-0.1	0.3	0.1	0.0
Major Depression (MDD)	0.1	0.1	0.3	-0.3	-0.5	0.0	0.5	-0.2	0.0	0.3
Crohns Disease (2012)	0.1	0.1	0.3	-0.3	-0.5	-0.3	-0.3	-0.5	0.3	-0.2
LDL Cholesterol	0.1	0.1	0.5	-0.4	-0.0	0.3	0.1	-0.2	-0.5	0.7
Schizophrenia (2014)	0.1	0.2	0.7	-0.2	0.0	0.5	0.4	-0.6	-0.8	-0.0
Blood Eosinophil Count	0.1	0.9	3.4	-0.1	-0.4	0.9	0.7	-1.8	-1.1	0.7
BMI	0.1	0.7	1.5	-0.9	0.2	-0.8	-1.2	-1.0	0.8	0.0
Waist Hip Ratio (WHR)	0.1	0.4	0.9	-0.5	0.6	0.2	-0.5	-0.4	0.7	1.0
Neuroticism	0.1	0.2	0.8	-0.2	0.6	-0.5	-0.1	0.3	0.4	0.9
Diabetes (mother)	0.1	0.1	0.3	-0.1	-0.5	-0.2	-0.3	-0.4	-0.5	-0.3
Trunk fat percentage	0.1	0.5	1.1	0.4	-0.7	-0.6	-0.6	-0.8	0.5	-1.0
Body mass index (BMI)	0.1	0.5	1.6	-0.2	0.8	-0.3	-0.9	-1.3	0.6	-0.3
Trunk fat mass	0.1	0.5	1.8	0.2	-0.2	-0.1	-0.3	-1.3	0.6	-1.2
Neuroticism score	0.1	0.3	0.9	0.2	0.9	0.4	0.4	-0.5	0.0	0.8
Weight	0.1	0.7	3.3	-0.1	0.7	0.1	-0.3	-1.8	0.7	-0.7
Arm fat percentage (right)	0.1	0.4	1.2	-0.1	0.4	-0.5	-0.9	-1.1	0.7	-0.2
Hip circumference	0.1	0.6	2.0	-0.0	0.5	-0.2	-1.0	-1.4	0.8	-0.4
Worrier / anxious feelings	0.1	0.1	0.5	0.4	-0.1	0.3	0.0	-0.3	0.3	-0.7
Arm fat mass (right)	0.1	0.4	1.4	0.4	0.7	0.2	-0.4	-1.2	0.6	-0.4
Standing height	0.1	0.7	1.7	0.2	-0.3	0.8	1.3	-1.3	0.1	-1.0
Glaucoma (self-reported)	0.1	0.2	0.4	0.5	-0.3	0.6	0.1	-0.4	0.4	0.1
Body fat percentage	0.1	0.4	0.9	0.3	-0.2	-0.4	-0.5	-1.0	0.7	-0.7
Leg fat percentage (right)	0.1	0.4	1.2	0.3	0.3	-0.1	-0.5	-0.5	0.9	-1.1
Age at first live birth	0.1	0.2	0.4	0.3	-0.6	0.4	0.0	0.6	-0.1	-0.2
Mean time to correctly identify matches	0.1	0.3	0.7	0.0	-0.4	0.1	-0.5	-0.3	0.8	-0.8
Whole body fat mass	0.1	0.5	1.9	0.2	0.2	0.0	-0.3	-1.4	0.9	-0.7
Leg fat mass (right)	0.1	0.4	1.0	0.4	0.5	0.3	-0.3	-1.0	0.9	-0.8
Arm fat percentage (left)	0.1	0.3	1.4	0.0	0.0	-0.2	-0.4	-1.2	0.8	-0.2
Arm fat mass (left)	0.1	0.4	1.7	0.1	0.6	0.1	-0.2	-1.3	0.6	-0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	-0.2	0.1	-0.1	-0.7	-0.4	0.1	-0.2
Leg fat percentage (left)	0.1	0.4	0.8	-0.0	0.5	-0.4	-0.7	-0.9	0.4	-0.9
Irritability	0.1	0.2	0.6	0.2	-0.4	0.6	0.5	-0.2	0.8	0.3
Leg fat mass (left)	0.1	0.4	1.1	0.3	0.7	0.2	-0.4	-1.1	0.6	-0.8
HDL Cholesterol	0.0	0.1	0.2	-0.1	0.4	-0.2	0.1	-0.4	-0.0	0.3
Height	0.0	0.8	2.1	-0.8	0.5	-0.2	0.8	-1.4	1.4	0.3
Hair Pigment	0.0	0.9	2.2	-0.9	0.9	-0.6	-0.7	-0.4	-1.3	-1.5
Tanning	0.0	0.4	1.2	-0.7	-0.5	-1.0	-0.2	-0.1	0.2	1.1
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.1	0.1	-0.3	0.2	-0.1	-0.3	0.2	0.2

Hub : Genes

SPATA13

Models

Trait associations