Hub : Genes

SPATS2L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1552 0.0550 2.4e-04 0.040 NA 0.039 NA 0.055 0.00041 NA 5.1e-04 NA 3.6e-05
2 GTEx Skin Not Sun Exposed Suprapubic 0.1310 0.0560 1.7e-03 0.063 NA 0.066 NA 0.070 0.00024 NA 1.7e-04 NA 1.1e-04
3 GTEx Thyroid 0.1010 0.0380 5.8e-04 0.041 NA 0.040 NA 0.041 0.00041 NA 4.6e-04 NA 4.0e-04
4 YFS Blood 0.0625 0.0171 2.0e-10 0.005 0.045 0.045 0.045 0.035 0.00800 1.9e-14 1.8e-14 1.7e-14 1.2e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 3.4 5.3 16.3 1.2 4.0 1.5 1.1
Bipolar Disorder or Schizophrenia 2.3 5.7 20.7 1.0 4.5 0.6 0.9
Depressed Affect (Nagel 2018) 3.6 7.6 23.7 4.9 2.2 -0.3 -1.3
Depression (Nagel 2018) 2.7 4.0 13.8 1.5 3.7 0.4 0.3
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.2 1.0 -2.1 -1.5 1.4
Neuroticism (Nagel 2018) 2.7 6.4 18.2 4.3 2.5 -0.3 -1.1
Schizophrenia (2018) 0.8 1.8 6.7 0.2 2.6 -0.5 0.3
Schizophrenia vs Biploar Disorder 0.5 0.6 1.5 -0.2 -1.2 -1.0 -0.2
Worry (Nagel 2018) 1.9 3.9 7.6 2.7 2.8 -1.0 0.3
Alzheimer’s Disease (in mother) 0.1 0.2 0.4 -0.4 0.1 0.4 0.6
Alzheimer’s Disease (in father) 0.5 0.6 1.3 0.2 -1.0 0.3 -1.1
Alzheimer’s Disease (including proxy) 0.3 0.5 1.1 -0.7 -0.5 1.0 -0.4
Crohns Disease (2017) 2.2 4.8 11.4 2.0 3.4 1.0 1.7
Irritable Bowel Disease (IBD) 2.6 6.1 11.6 3.2 3.4 -0.1 1.6
Ulcerative Colitis (UC) 1.5 2.8 6.4 2.5 1.6 -1.4 0.6
Major Depression (MDD) 2.2 2.7 10.3 -0.2 3.2 0.4 -0.2
Reaction Time 6.8 12.9 41.8 -0.1 6.5 2.4 2.0
Verbal and Numeric Reasoning (VNR) 1.3 3.2 9.9 0.9 -3.1 -0.8 -1.2
Breast Cancer 0.1 0.3 1.0 -0.4 -1.0 -0.1 0.5
Ovarian Cancer 0.3 0.4 0.6 -0.5 -0.8 -0.6 -0.4
Prostate Cancer 0.7 0.9 3.4 -0.1 0.5 -1.9 0.2
Age at First Birth 0.5 0.7 2.1 -0.4 -1.4 -0.8 -0.2
Bipolar Disorder (2011) 1.2 1.2 1.8 -1.3 1.3 -0.9 0.6
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 -0.5 -0.1 -0.4 0.4
Coronary Artery Disease (CAD) 0.6 0.7 1.3 -0.8 -1.0 1.1 0.1
Crohns Disease (2012) 1.6 2.5 4.6 2.0 2.1 1.1 0.3
Mean Putamen Volume 0.7 0.7 1.6 0.8 0.8 -0.3 1.3
Fasting Glucose 0.7 0.9 1.3 0.2 1.1 1.0 1.1
HbA1C 0.9 1.0 2.2 0.4 1.5 1.2 0.2
HDL Cholesterol 0.2 0.4 0.9 -0.0 -0.7 -0.1 -1.0
LDL Cholesterol 0.2 0.3 0.8 -0.3 0.3 0.9 -0.2
Lupus 1.0 1.6 3.0 1.7 1.2 -0.1 1.3
Neuroticism (2016) 1.0 1.4 2.9 1.4 -0.8 -0.6 -1.7
Primary Biliary Cirrhosis 0.5 0.7 1.2 -0.7 1.1 0.7 0.8
Rheumatoid Arthritis 0.6 0.8 2.1 -1.5 1.0 0.4 0.1
Schizophrenia (2014) 1.2 2.6 10.3 0.3 3.2 0.4 -0.1
Triglycerides 0.6 0.9 2.7 -1.6 -1.0 -0.2 -0.3
Type 2 Diabetes (T2D) (2012) 0.7 0.9 2.2 -0.6 -0.2 1.5 -0.9
Ulcerative Colitis 0.7 1.1 3.1 1.8 0.5 -0.7 -0.5
Blood Eosinophil Count 0.3 2.1 4.9 -1.4 -2.2 0.4 -1.2
Blood Platelet Count 0.0 0.5 1.2 0.5 0.3 -0.8 1.1
Blood Red Count 1.1 10.4 20.9 -3.9 -4.6 -0.8 -2.3
Blood White Count 0.4 2.8 8.8 0.6 3.0 1.4 -0.2
Heel T-Score 0.8 6.3 18.6 1.0 -0.9 -4.3 2.2
BMI 0.7 4.3 7.2 -2.7 -2.3 1.2 -1.8
Height 0.2 4.7 8.9 1.3 -0.5 2.9 -3.0
Waist Hip Ratio (WHR) 0.6 2.5 5.6 -0.3 -2.4 0.2 -2.1
Systolic Blood Pressure 2.2 11.2 18.7 2.6 3.9 -4.3 2.0
Smoking Status 2.6 6.1 11.9 1.5 1.2 3.0 -3.4
Allergy or Eczema 0.5 1.2 2.5 -1.0 -0.8 -0.7 1.6
Cardiovascular Disease 1.6 5.3 12.5 1.9 3.5 -0.7 2.2
Hypothyroidism (self reported) 2.0 4.5 9.2 1.2 2.1 3.0 -1.7
Respiratory disease 0.2 0.4 1.0 1.0 -0.1 -0.0 -0.7
Type 2 Diabetes (T2D) (2018) 1.1 2.0 3.7 0.1 1.0 1.9 -1.8
Lung FEV1/FVC ratio 2.0 9.9 25.1 -3.2 0.0 -5.0 2.1
Lung FVC 1.4 7.0 16.0 1.4 -4.0 -3.1 -0.8
Neuroticism 2.1 5.1 17.3 4.2 1.1 -0.8 -1.1
Chronotype (morning person) 0.6 1.4 4.8 -0.3 -0.7 -2.2 -0.5
Hair Pigment 0.0 0.7 1.8 -1.4 0.1 -0.5 0.8
Tanning 0.1 1.6 2.2 1.0 1.2 -1.5 1.4
Hand grip strength (left) 3.1 8.1 17.5 -0.6 -2.9 2.6 -4.2
Number of treatments/medications taken 0.2 0.3 0.6 0.1 0.7 0.3 0.8
Average weekly spirits intake 1.7 2.2 4.7 0.4 1.9 2.2 0.3
Sensitivity / hurt feelings 0.8 1.4 3.5 1.2 -0.7 -0.2 -1.9
Frequency of depressed mood in last 2 weeks 1.7 2.4 4.8 2.2 1.3 -1.0 -1.4
Hearing difficulty/problems: Yes 0.5 0.8 2.2 -1.5 0.3 1.0 -0.2
Relative age of first facial hair 0.7 1.5 4.0 -1.2 -0.6 0.5 -2.0
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.3 -1.3 0.1 1.1 -1.5
Ever used hormone-replacement therapy (HRT) 1.4 1.7 4.1 0.5 1.5 2.0 -0.5
Ever had hysterectomy (womb removed) 0.7 0.8 1.7 0.9 0.6 1.3 0.4
Systolic blood pressure, automated reading 1.2 3.3 6.6 1.5 1.7 -2.6 1.3
Eye problems/disorders: Diabetes related eye disease 3.7 4.0 12.1 1.6 3.5 1.1 0.2
Angina 1.8 2.4 5.5 1.6 2.4 1.3 0.0
Medication for hormone replacement therapy 0.4 0.4 0.8 0.5 0.3 0.7 -0.9
Vitamin and mineral supplements 0.4 0.5 1.5 -0.5 0.3 0.0 -1.2
Supplements: Zinc 2.7 2.9 6.7 -1.0 -2.6 0.3 -2.0
Medication: Co-codamol 0.3 0.3 0.7 -0.3 0.8 -0.8 -0.1
Medication: Metformin 0.5 0.8 2.0 0.9 -0.0 0.4 -1.4
Diabetes (father) 0.3 0.4 1.2 1.1 -0.1 0.5 -0.3
Diabetes (mother) 0.6 0.8 1.7 0.3 0.2 1.2 -1.3
Severe depression (siblings) 1.5 1.7 4.5 2.1 0.7 0.8 -1.1
Pack years adult smoking proportion 0.8 1.2 2.0 1.3 1.0 0.1 1.4
Impedance of leg (right) 2.0 9.7 22.5 3.0 4.7 -0.8 2.5
Leg fat-free mass (left) 1.1 5.6 9.2 -1.0 -2.7 2.2 -3.0
Trunk fat percentage 0.6 2.5 5.9 1.2 2.4 1.6 0.3
Hand grip strength (right) 2.3 6.2 11.6 0.4 -1.6 3.2 -3.4
Townsend deprivation index at recruitment 1.7 2.4 6.2 2.5 1.8 0.1 0.3
Current tobacco smoking 1.2 2.0 3.4 1.8 1.0 0.7 -1.8
Average weekly fortified wine intake 1.2 1.4 2.8 -1.7 -0.9 1.2 -0.6
Maternal smoking around birth 1.6 2.4 8.2 0.4 1.0 2.9 -0.2
Fed-up feelings 3.4 6.2 15.2 3.9 2.6 -0.0 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 3.2 4.3 8.2 2.9 2.8 0.9 -0.5
Relative age voice broke 0.8 1.2 2.4 -1.4 -0.5 -0.6 -1.5
Taking other prescription medications 0.2 0.4 0.9 -0.5 0.9 0.3 0.6
Age when periods started (menarche) 1.3 3.2 5.3 1.7 2.3 2.1 0.1
Bilateral oophorectomy (both ovaries removed) 2.9 3.4 7.4 0.4 2.3 2.7 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 2.2 5.0 13.5 -0.0 -1.0 -3.7 2.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.1 0.4 0.7 1.0 0.4
Qualifications: CSEs or equivalent 1.0 1.3 2.1 0.2 1.4 1.2 -1.3
Serious illness, injury or assault to yourself 1.3 1.6 3.3 1.8 1.6 -0.9 -0.0
High blood pressure 1.5 4.1 10.0 1.8 3.2 0.0 1.8
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.3 -1.5 -1.2 -0.6 0.6
Multivitamins +/- minerals 0.5 0.7 2.0 0.8 -0.0 -0.4 1.4
Stomach or abdominal pain in last month 1.6 2.0 4.5 2.1 1.5 -0.6 0.9
Supplements: Glucosamine 1.3 1.7 6.4 -0.5 -2.5 -0.2 0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.3 0.4 -0.3 0.6 -0.4
Medication: Atenolol 0.6 0.8 1.1 0.7 -0.7 -1.0 1.0
Medication: Levothyroxine sodium 2.0 3.4 5.9 2.4 2.3 1.6 -0.3
Sitting height 1.0 6.8 15.2 -0.3 -2.6 2.3 -3.9
Chronic bronchitis/emphysema (father) 1.0 1.2 2.3 1.2 0.9 1.5 -0.5
High blood pressure (mother) 1.5 2.1 3.8 1.7 1.9 -0.5 1.2
Body mass index (BMI) 0.1 0.6 1.7 -0.4 -0.2 1.3 -0.7
Impedance of leg (left) 1.6 7.6 18.5 2.7 4.3 -0.5 2.1
Leg predicted mass (left) 1.0 5.5 9.0 -1.1 -2.6 2.2 -3.0
Trunk fat mass 0.4 1.8 4.5 0.8 1.3 2.1 -0.7
Waist circumference 0.5 2.0 4.5 -0.0 -0.2 2.1 -1.9
Number of incorrect matches in round 0.8 1.3 2.7 0.7 1.1 1.6 -1.0
Past tobacco smoking 2.7 5.0 10.8 0.5 -0.1 -3.3 3.0
Alcohol usually taken with meals 3.0 4.8 11.5 -2.4 -3.4 -1.3 -0.4
Nervous feelings 1.1 2.0 5.2 2.3 0.2 -1.4 -1.0
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 9.9 3.1 3.1 -0.6 0.6
Hearing difficulty/problems with background noise 2.2 3.5 8.3 -0.3 -2.9 0.1 -2.3
Hair/balding pattern: Pattern 2 2.2 2.8 4.4 1.5 2.1 -1.2 1.7
Had menopause 0.2 0.3 0.6 -0.8 -0.4 0.5 -0.1
Had other major operations 2.2 2.7 6.6 -1.4 0.9 2.6 -1.2
Forced vital capacity (FVC) 1.5 5.8 14.6 0.7 -3.8 -0.7 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.6 6.2 0.4 -1.7 -2.5 1.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 0.7 0.4 0.8 0.4 -0.9
Qualifications: None of the above 2.8 6.0 16.5 1.9 4.1 1.5 1.4
Financial difficulties in last 2 years 1.2 1.7 2.9 -0.5 1.7 0.8 -1.7
Mouth/teeth dental problems 2.1 3.3 7.0 -1.7 -2.6 -1.7 0.5
Heart attack 1.3 1.6 4.6 1.3 2.1 0.3 0.4
Allergy 0.2 0.5 0.8 0.7 0.8 0.9 -0.5
Pain all over the body in last month 0.1 0.2 0.4 -0.6 0.3 0.2 -0.4
Diabetes (self-reported) 0.4 0.6 1.6 0.8 0.2 0.2 -1.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 2.3 -1.5 -0.3 -0.3 0.1
Medication: Ramipril 1.3 1.7 3.8 -0.2 1.9 0.2 1.7
Medication: Simvastatin 1.9 2.8 8.2 1.3 2.9 -0.3 1.1
Fluid intelligence score 0.5 1.1 3.1 0.4 -1.8 -1.0 -0.2
Illnesses of siblings 1.3 1.9 4.7 -1.6 -2.2 0.1 -0.6
Neuroticism score 2.5 5.2 15.3 3.9 0.5 -1.7 -1.6
Weight 0.6 3.0 6.4 -0.4 -0.9 2.5 -2.2
Impedance of arm (right) 1.5 6.9 11.1 2.0 3.3 -2.3 2.7
Arm fat percentage (right) 0.2 0.6 1.3 0.3 1.1 0.9 0.6
Trunk fat-free mass 1.6 9.3 14.1 -1.3 -3.7 2.8 -3.8
Hip circumference 0.5 2.1 4.9 -0.5 0.5 2.2 -1.7
Time employed in main current job 0.5 0.6 1.6 0.8 -0.0 1.2 -0.5
Alcohol intake versus 10 years previously 2.8 4.1 6.2 2.3 2.2 2.5 -0.5
Father’s age at death 0.3 0.4 1.3 0.2 0.1 -0.2 1.2
Worrier / anxious feelings 1.3 2.4 5.2 1.3 1.4 -2.3 0.9
Frequency of tiredness / lethargy in last 2 weeks 3.3 5.4 11.5 3.4 2.5 1.4 -1.4
Falls in the last year 1.2 1.7 2.9 -1.7 -1.1 1.6 -0.2
Hair/balding pattern: Pattern 3 1.2 1.8 5.0 -0.7 -1.1 2.2 -0.6
Number of live births 0.8 1.1 2.7 -0.3 0.3 1.3 1.6
Forced expiratory volume in 1-second (FEV1) 1.2 3.9 8.9 -0.4 -3.0 -1.4 -2.2
Pulse rate 4.0 6.7 14.4 0.5 -3.3 1.2 -3.8
Happiness 0.9 1.0 1.6 1.3 0.7 -1.0 -1.0
Noisy workplace 0.8 1.0 3.0 0.8 0.5 -0.3 1.7
Qualifications: A levels/AS levels or equivalent 3.7 8.1 15.2 -3.5 -3.9 0.1 -2.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.3 0.5 1.5 -0.4 0.9
Mouth/teeth dental problems: Dentures 2.1 3.5 9.6 1.9 3.1 0.6 0.4
Asthma 0.1 0.2 0.4 0.4 -0.7 -0.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.3 0.5 -0.5 1.1 -0.2
Medication: Cholesterol lowering 0.7 1.2 3.6 0.8 1.9 0.3 0.6
Depression (self-reported) 0.2 0.2 0.4 -0.5 -0.2 -0.6 -0.5
Medication: Lansoprazole 1.5 1.7 5.6 0.0 1.0 2.4 -0.4
Prospective memory result 0.3 0.4 1.3 0.2 0.4 -0.4 1.2
Lung cancer (father) 3.1 3.6 9.4 1.5 3.1 1.3 1.1
Illnesses of mother 0.6 0.8 1.9 0.1 -1.0 -1.4 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 4.8 -0.5 -2.2 -1.3 -1.8
Pulse wave Arterial Stiffness index 0.3 0.3 0.9 -0.9 -0.5 -0.1 0.5
Impedance of arm (left) 1.6 7.4 14.4 2.2 3.8 -2.0 2.5
Arm fat mass (right) 0.2 0.7 2.5 0.2 0.1 1.6 -0.6
Trunk predicted mass 1.6 9.1 14.1 -1.2 -3.6 2.8 -3.8
Standing height 0.6 6.1 12.9 -0.1 -1.6 3.0 -3.6
Length of working week for main job 0.8 0.9 1.5 -1.1 1.2 1.0 0.0
Exposure to tobacco smoke at home 4.0 4.5 9.5 1.9 3.1 1.8 -1.4
Breastfed as a baby 0.6 0.8 1.8 -0.9 -1.3 -0.5 -0.5
Tense / ‘highly strung’ 1.2 2.0 6.6 2.6 0.2 -1.0 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 4.7 0.4 2.2 1.3 0.6
Hair/balding pattern: Pattern 4 1.9 4.6 8.9 -3.0 -2.1 2.0 -1.2
Birth weight of first child 0.4 0.7 2.1 1.5 0.2 -0.3 0.7
Peak expiratory flow (PEF) 0.6 1.3 2.6 -0.8 -1.6 -0.6 -1.2
Pulse wave reflection index 1.0 1.2 2.8 -0.4 1.3 0.5 1.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.0 0.0 0.1 -1.0 -0.4
Loud music exposure frequency 0.8 0.8 3.2 0.1 -1.8 0.0 0.3
Qualifications: O levels/GCSEs or equivalent 2.3 3.6 10.0 -1.8 -3.2 -0.6 -0.9
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.8 -0.3 -0.3 1.2 -1.7
Blood clot in the leg (DVT) 0.6 0.8 1.9 0.3 0.9 -0.7 1.4
Medication: Paracetamol 1.6 2.7 5.2 2.3 1.9 0.5 1.4
Headache pain in last month 1.8 3.2 5.2 1.6 1.7 -1.4 2.3
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 5.5 -1.5 -2.3 -0.3 -0.1
Glaucoma (self-reported) 0.8 1.0 1.7 1.2 1.3 0.1 0.9
Gout (self-reported) 0.9 1.2 3.3 -1.8 -1.0 -0.8 -0.2
Hypothyroidism/myxoedema (self-reported) 1.9 3.6 5.4 2.0 2.3 2.2 -0.7
Medication: Amlodipine 0.4 0.6 1.9 -0.5 -0.3 -1.4 -0.2
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.2 1.1 1.8 0.5 0.0
Birth weight 0.2 0.3 0.8 0.7 0.3 -0.9 0.0
Chronic bronchitis/emphysema (mother) 2.4 2.9 6.7 -0.7 2.0 2.6 0.5
High blood pressure (siblings) 0.5 0.7 1.0 1.0 0.9 0.9 -0.2
Forced vital capacity (FVC), Best measure 1.0 3.8 7.9 0.2 -2.7 -0.3 -2.8
Body fat percentage 0.6 2.3 5.6 1.2 2.4 1.4 0.5
Leg fat percentage (right) 0.6 2.3 5.1 1.3 2.3 1.4 0.6
Arm fat-free mass (right) 1.4 7.3 12.1 -0.8 -2.7 3.0 -3.5
Exposure to tobacco smoke outside home 1.5 1.9 4.2 1.6 2.1 1.0 -0.2
Comparative body size at age 10 1.0 2.7 6.5 -1.1 -1.4 -2.5 1.0
Number of full brothers 0.3 0.4 0.7 -0.8 0.3 -0.2 -0.8
Worry too long after embarrassment 1.0 1.7 5.0 1.4 -0.2 0.0 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.2 0.8 1.3 1.5 -0.0
Wheeze or whistling in the chest in last year 1.7 3.0 7.2 2.7 1.7 1.3 -0.1
Number of children fathered 0.4 0.5 0.9 -1.0 -0.4 0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.6 0.3 0.8 0.6 0.6
Age at first live birth 1.1 1.9 5.1 -1.4 -2.3 -0.2 -0.7
Pulse wave peak to peak time 0.4 0.5 0.9 1.0 0.4 0.3 -0.8
Health satisfaction 0.7 0.9 3.0 1.7 0.2 -0.8 0.3
Shortness of breath walking on level ground 0.1 0.1 0.2 0.3 0.1 0.5 0.4
Qualifications: College or University degree 3.2 10.2 21.3 -3.6 -4.6 -2.5 0.7
Eye problems/disorders: None of the above 0.9 1.0 1.7 -1.3 -0.7 0.6 -1.2
Mouth/teeth dental problems: Loose teeth 2.7 3.2 6.8 -1.1 1.4 2.6 -1.7
Emphysema/chronic bronchitis 2.2 2.4 4.9 2.2 1.7 1.3 0.4
Medication for pain relief, constipation, heartburn 2.9 4.9 7.5 -2.7 -2.6 -1.7 -1.7
Neck or shoulder pain in last month 0.7 1.0 3.1 0.1 0.4 0.9 -1.8
Medication: Blood pressure 0.9 1.5 3.2 1.7 1.8 0.1 -0.5
Angina (self-reported) 1.6 2.1 5.2 1.2 2.3 1.3 -0.2
Migraine (self-reported) 1.1 1.4 2.2 0.4 -1.4 -1.5 1.1
Medication: Ibuprofen 0.4 0.5 1.8 -0.1 -1.3 0.2 0.2
Medication: Allopurinol 1.3 1.8 6.1 -2.5 -0.7 -0.6 0.3
Medication: Omeprazole 1.5 1.8 4.7 1.0 2.2 1.2 -0.4
Medication: Seretide 50 evohaler 0.3 0.4 0.8 0.4 0.7 -0.9 0.3
Mean time to correctly identify matches 5.7 10.8 33.4 -0.8 5.8 2.7 1.5
Heart disease (mother) 1.0 1.2 3.0 -1.3 0.4 1.7 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.6 1.6 0.0 0.5 -0.8
Whole body fat mass 0.3 1.4 3.8 0.8 1.0 1.9 -0.6
Leg fat mass (right) 0.4 1.6 4.0 1.1 0.9 2.0 -0.7
Arm predicted mass (right) 1.3 6.9 12.2 -0.7 -2.5 2.9 -3.5
Pulse rate, automated reading 5.4 17.5 30.2 -1.8 -4.9 3.5 -5.5
Alcohol intake frequency. 1.1 2.6 5.0 1.9 0.9 -2.2 1.1
Comparative height size at age 10 0.1 0.6 1.7 0.1 -1.3 0.7 -0.4
Number of full sisters 1.5 1.9 6.1 0.9 2.5 -0.6 0.5
Suffer from ‘nerves’ 1.3 2.1 6.8 1.2 2.6 0.2 -0.4
Overall health rating 3.8 8.1 14.4 2.8 3.8 2.8 -1.5
Chest pain or discomfort 1.6 2.3 6.1 2.5 1.1 1.3 -0.7
Had major operations 1.1 1.3 2.0 -0.0 1.4 1.4 -1.1
Age at last live birth 0.4 0.6 2.1 -0.1 -1.4 -0.4 -0.3
Family relationship satisfaction 1.6 1.9 5.7 -0.4 0.4 1.3 -2.4
Leg pain on walking 0.4 0.5 1.4 -0.8 0.2 -0.0 -1.2
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 2.0 0.8 1.4 1.0 1.4
Commuting to job workplace: Car/motor vehicle 0.8 1.0 1.8 -0.6 1.3 1.2 -0.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.1 -1.0 -1.8 -0.1 -0.6
Medication: Aspirin 1.0 1.4 2.0 1.1 1.4 1.4 0.5
Supplements: Vitamin C 0.8 0.9 3.0 1.7 0.1 0.6 0.6
Knee pain experienced in last month 0.2 0.4 1.1 1.1 -0.4 -0.2 -0.3
Hypertension (Self-reported) 1.6 4.5 10.2 2.1 3.2 0.2 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.1 4.7 8.7 3.0 2.9 0.4 1.3
Illnesses of father: Heart disease 0.5 0.6 1.3 0.0 -1.1 0.3 -1.1
Illnesses of siblings: Diabetes 0.8 0.9 1.9 -0.3 0.6 1.2 -1.4
Smoking status: Previous 1.5 2.2 5.6 -0.1 -0.3 2.4 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.6 -1.0 -0.9 0.9 -1.9
Whole body fat-free mass 1.5 8.5 13.2 -1.3 -3.3 2.8 -3.6
Leg fat-free mass (right) 1.4 7.5 12.5 -1.4 -3.1 2.4 -3.5
Arm fat percentage (left) 0.3 1.1 2.9 0.6 1.7 0.9 0.6
Average weekly red wine intake 2.5 3.6 7.5 -1.9 -2.7 0.6 -1.8
Handedness (chirality/laterality): Left-handed 1.2 1.5 2.1 1.2 1.3 -1.5 0.6
Mood swings 3.4 6.1 19.6 4.4 1.5 -1.5 -0.3
Loneliness, isolation 1.1 1.5 4.2 1.2 0.7 -0.1 -2.0
Long-standing illness, disability or infirmity 2.2 3.3 8.5 -0.6 2.0 2.9 -0.5
Ever had bowel cancer screening 5.2 6.1 20.6 -0.7 1.3 4.5 -1.2
Diabetes diagnosed by doctor 0.7 1.1 3.2 0.2 -0.1 1.1 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.6 -0.1 1.3 1.1 0.1
Friendships satisfaction 0.5 0.7 1.7 -0.7 0.2 -1.3 -0.7
Qualifications: nursing, teaching 3.2 5.0 7.5 -2.2 -2.7 -2.4 1.4
Commuting to job workplace: Walk 0.8 0.9 1.4 0.8 -0.4 -1.1 1.2
Eye problems/disorders: Cataract 0.5 0.5 1.0 0.7 -1.0 -0.8 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.9 3.0 5.4 2.3 1.4 2.1 -0.4
Medication for cholesterol 1.4 2.1 4.2 -2.1 -1.5 -0.4 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 4.6 2.1 1.3 0.9 -0.8
Back pain experienced in last month 0.5 0.7 1.6 0.7 1.3 0.7 0.3
Mineral and other dietary supplements 1.6 2.1 5.8 1.6 2.4 -0.2 -0.2
Breast cancer (self-reported) 0.4 0.5 1.0 1.0 0.8 -0.4 0.0
Asthma (self-reported) 0.1 0.2 0.6 0.2 -0.5 -0.8 -0.1
Osteoporosis (self-reported) 0.7 0.9 1.4 -1.0 -0.7 1.2 -0.8
Osteoarthritis (self-reported) 1.1 1.5 4.3 -0.6 0.6 2.1 -0.9
Medication: Aspirin 0.6 0.7 1.1 0.7 1.1 1.0 0.6
Medication: Gliclazide 0.6 0.7 1.7 -0.8 0.5 1.3 -0.2
Illnesses of father: None of the above (group 1) 0.6 0.8 2.7 -1.6 0.0 -0.6 -0.1
Smoking status: Current 1.1 1.8 3.2 1.8 1.1 0.4 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 10.4 -0.2 -1.4 -3.2 0.6
Whole body water mass 1.5 8.6 13.5 -1.4 -3.2 2.9 -3.7
Leg predicted mass (right) 1.4 7.4 12.7 -1.3 -3.1 2.4 -3.6
Arm fat mass (left) 0.3 1.0 3.2 0.4 0.4 1.8 -0.8
Number of self-reported non-cancer illnesses 1.2 2.1 4.5 0.2 1.9 2.1 -0.2
Average weekly champagne plus white wine intake 2.3 3.1 8.0 -2.8 -1.4 -0.4 1.6
Miserableness 4.0 7.0 23.6 4.9 1.7 -1.0 0.6
Guilty feelings 1.0 1.5 4.7 -0.9 -0.6 0.4 -2.2
Wears glasses or contact lenses 0.8 0.9 2.4 -1.6 -1.0 -0.6 0.2
Ever taken oral contraceptive pill 0.0 0.1 0.1 0.2 -0.2 0.2 -0.3
Hearing aid user 0.8 0.9 2.6 -0.7 1.6 0.2 0.6
Mother’s age at death 1.8 2.3 4.4 -1.4 -2.1 1.6 -0.6
Financial situation satisfaction 0.8 1.0 2.8 0.8 0.9 0.1 -1.7
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.4 -1.6 0.3 -0.3 -0.2
Commuting to job workplace: Public transport 0.6 0.7 1.4 -1.2 0.1 -1.0 -0.3
Eye problems/disorders: Glaucoma 0.7 0.8 1.7 1.3 0.8 -0.1 1.0
Medication: Blood pressure 1.6 3.1 5.3 1.7 2.0 -0.0 2.3
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.4 0.4 -0.5 0.6
Supplements: Fish oil (including cod liver oil) 0.9 1.1 2.2 -1.4 -1.5 0.4 0.3
High cholesterol (Self-reported) 1.4 2.6 5.7 1.9 2.4 0.0 1.1
Medication: Bendroflumethiazide 1.6 2.5 5.1 2.0 2.3 0.3 0.9
Medication: Paracetamol 1.5 2.4 3.9 1.6 1.4 -1.0 2.0
Medication: Lisinopril 2.7 3.6 6.7 1.2 2.6 -1.3 2.1
Medication: Atorvastatin 1.0 1.2 2.3 1.2 0.8 1.5 -0.6
Illnesses of father: High blood pressure 2.5 3.0 6.9 2.6 1.6 -0.9 1.3
Alcohol drinker status: Never 2.1 2.5 3.6 1.7 -1.9 -1.8 0.4
Ever smoked 3.4 6.0 13.1 -0.9 0.0 3.6 -3.2
Basal metabolic rate 1.3 7.0 11.6 -1.0 -2.8 2.8 -3.4
Leg fat percentage (left) 0.4 1.3 2.6 0.7 1.6 1.5 0.3
Arm fat-free mass (left) 1.6 8.1 12.8 -1.1 -3.1 3.0 -3.6
Number of operations (self-reported) 2.4 3.6 8.6 -1.6 1.2 2.9 -1.4
Average weekly beer plus cider intake 1.8 2.7 5.1 1.6 2.2 1.7 -0.6
Irritability 2.3 3.9 11.3 3.4 -0.1 -0.9 -1.9
Risk taking 1.6 2.3 4.4 -2.1 -1.0 -1.0 1.7
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.2 -0.7 -0.8 1.1 0.2
Fractured/broken bones in last 5 years 1.7 2.2 4.7 -0.2 2.2 2.0 0.6
Age started oral contraceptive pill 1.5 1.9 6.1 0.3 -2.5 -1.0 0.7
Diastolic blood pressure, automated reading 0.0 0.1 0.1 -0.2 0.4 -0.3 -0.1
Ever depressed for a whole week 2.0 2.5 5.5 1.5 1.2 1.0 -2.3
Unable to work because of sickness or disability 3.0 3.9 10.9 0.9 3.3 -0.3 1.9
Commuting to job workplace: Cycle 2.0 2.5 4.2 -1.6 -1.7 -2.1 0.2
Myopia 0.5 0.7 1.4 -0.4 -1.1 -1.2 -0.1
Vascular/heart problems diagnosed by doctor 2.0 5.6 14.2 -2.0 -3.8 0.0 -2.0
Cholesterol lowering medication 1.0 1.4 3.0 1.7 1.5 0.6 0.3
Medication: Omeprazole (e.g. Zanprol) 2.0 2.5 4.7 1.6 2.2 1.6 -0.3
Pain experienced in last month 0.6 1.0 1.9 -1.1 -1.4 -0.2 -1.1
Supplements: Calcium 2.7 3.0 8.6 -0.8 -2.9 -0.1 -1.6
Basal cell carcinoma (self-reported) 0.5 0.5 1.2 -1.1 -0.2 0.2 -0.9
Heart attack/myocardial infarction (self-reported) 1.7 2.2 6.6 1.2 2.6 0.3 0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.9 0.1 1.0 -0.4 1.4
Heart disease (siblings) 1.0 1.2 3.1 0.8 1.8 0.5 1.0
Alcohol drinker status: Previous 0.6 0.7 1.6 -0.8 1.3 -0.6 0.4
Pack years of smoking 0.9 1.4 2.0 1.4 1.2 0.4 1.4
Impedance of whole body 1.8 9.1 18.9 2.7 4.3 -1.6 2.8
Leg fat mass (left) 0.3 1.3 4.1 0.6 0.5 2.0 -0.7
Arm predicted mass (left) 1.5 7.4 11.6 -0.9 -2.9 3.0 -3.4