TWAS hub - SPINK5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.135	0.0382	0.0e+00	0.159	0.154	0.176	NA	0.179	2.1e-31	2.8e-30	1.1e-34	NA	2.7e-35
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.101	0.0383	1.7e-11	0.059	0.096	0.092	NA	0.085	2.9e-07	6.4e-11	1.8e-10	NA	8.8e-10
3	TCGA	Pheochromocytoma and Paraganglioma	0.249	0.0930	3.5e-06	0.103	0.182	0.169	NA	0.161	6.9e-05	9.6e-08	3.0e-07	NA	6.0e-07
4	TCGA	Soft Tissue Sarcoma	0.102	0.0410	2.3e-06	0.138	0.108	0.096	NA	0.125	1.5e-08	5.7e-07	2.7e-06	NA	7.0e-08
5	TCGA	Stomach Adenocarcinoma	0.060	0.0340	2.0e-03	0.029	0.018	0.005	NA	0.017	3.5e-03	1.7e-02	1.4e-01	NA	2.1e-02
6	TCGA	Thyroid Carcinoma	0.484	0.0650	0.0e+00	0.395	0.391	0.479	NA	0.467	8.6e-41	2.7e-40	1.8e-52	NA	1.0e-50

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Reason for reducing amount of alcohol drunk: Health precaution	11.0	12.9	14.0	-3.5	-3.2	-3.7	-3.7	-3.7	-3.6
Severe depression (siblings)	4.8	5.3	6.1	-2.3	-2.1	-2.5	-2.4	-2.3	-2.2
Lung FEV1/FVC ratio	4.2	21.3	34.2	-4.8	-5.8	-3.6	-4.8	-4.8	-3.5
Alcohol drinker status: Previous	4.2	4.8	7.6	-2.2	-2.1	-2.8	-2.1	-1.5	-2.2
Pain experienced in last month	3.8	6.4	7.3	2.6	2.6	2.7	2.5	2.4	2.3
Eye problems/disorders: Glaucoma	3.7	4.4	8.0	2.0	2.0	2.5	1.9	0.8	2.8
Osteoporosis (self-reported)	3.6	4.5	5.2	-2.3	-2.2	-2.0	-2.2	-2.3	-1.6
Alcohol drinker status: Never	3.5	4.2	6.0	-2.1	-1.8	-2.4	-1.8	-1.7	-2.3
Leg pain on walking	3.2	4.1	5.4	-2.3	-2.1	-2.0	-1.6	-1.7	-2.3
Type 2 Diabetes (T2D) (2012)	3.1	3.6	4.5	-1.8	-1.9	-2.0	-2.1	-2.1	-1.4
Pain all over the body in last month	3.1	3.4	5.2	-2.0	-2.3	-1.7	-1.6	-1.8	-1.5
Suffer from ‘nerves’	3.1	4.9	7.2	-2.2	-2.1	-2.7	-2.2	-2.0	-2.0
High cholesterol (Self-reported)	3.0	5.4	6.9	-2.5	-2.2	-1.7	-2.3	-2.5	-2.6
Number of live births	2.8	4.0	6.1	1.8	1.3	2.3	2.5	2.0	1.9
Eye problems/disorders: None of the above	2.8	3.2	6.0	-1.5	-1.5	-2.5	-2.1	-1.4	-1.6
Mean time to correctly identify matches	2.8	5.4	6.6	-2.5	-2.6	-2.2	-2.2	-2.1	-2.4
Schizophrenia vs Biploar Disorder	2.7	3.6	6.0	-1.9	-1.4	-1.2	-2.1	-2.5	-2.0
Noisy workplace	2.5	3.0	4.6	-2.1	-1.6	-1.5	-1.8	-1.4	-1.9
Townsend deprivation index at recruitment	2.4	3.3	4.4	-1.9	-2.0	-1.3	-1.6	-2.0	-2.1
Mood swings	2.4	4.3	7.7	-2.0	-1.6	-2.8	-2.1	-1.2	-2.3
Risk taking	2.4	3.6	5.3	-1.8	-2.3	-1.5	-1.9	-2.3	-1.4
Ever had hysterectomy (womb removed)	2.3	2.6	3.9	-1.5	-1.4	-2.0	-1.6	-1.2	-2.0
Knee pain experienced in last month	2.3	3.5	5.2	-1.8	-1.9	-1.8	-1.7	-1.7	-2.3
Number of self-reported non-cancer illnesses	2.3	4.1	5.3	-2.2	-2.2	-1.8	-1.8	-2.3	-1.7
Mother’s age at death	2.3	2.9	3.4	1.9	1.6	1.6	1.7	1.8	1.7
High blood pressure (siblings)	2.1	3.0	4.2	-1.7	-1.2	-1.6	-2.0	-2.1	-1.6
Medication for hormone replacement therapy	2.0	2.2	3.1	1.6	1.5	1.4	1.8	1.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.0	-1.7	-1.5	-1.7	-1.1	-1.4	-1.5
Loud music exposure frequency	2.0	2.2	3.7	-1.3	-1.2	-1.4	-1.8	-1.9	-1.1
HDL Cholesterol	1.9	3.2	3.9	-1.9	-1.8	-1.7	-2.0	-1.3	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	3.9	-2.0	-1.7	-1.7	-1.6	-1.3	-1.9
Glaucoma (self-reported)	1.8	2.1	4.5	1.2	1.1	2.0	1.1	-0.1	2.1
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.1	-1.6	-1.8	-1.6	-1.3	-1.2	-1.4
Unable to work because of sickness or disability	1.8	2.4	4.2	-1.8	-2.1	-1.5	-1.2	-1.3	-1.2
Lupus	1.7	2.5	3.7	1.7	1.5	1.2	1.7	1.5	1.9
Number of full brothers	1.7	2.2	3.2	-1.8	-1.8	-1.1	-1.5	-1.4	-1.3
Medication: Seretide 50 evohaler	1.7	2.0	3.0	-1.4	-1.0	-1.2	-1.3	-1.7	-1.7
Heart disease (mother)	1.7	2.1	2.6	-1.4	-1.1	-1.4	-1.4	-1.6	-1.6
Average weekly red wine intake	1.7	2.5	4.7	1.7	2.2	1.3	1.3	0.6	1.9
Alcohol intake versus 10 years previously	1.6	2.4	3.2	1.7	1.8	1.3	1.5	1.7	1.2
Pulse wave reflection index	1.6	2.0	3.0	-1.6	-1.2	-1.6	-1.7	-1.1	-1.2
Health satisfaction	1.6	2.1	3.3	-1.8	-1.7	-0.9	-1.4	-1.4	-1.2
Back pain experienced in last month	1.6	2.3	4.0	-1.7	-2.0	-1.2	-1.1	-1.2	-1.7
Miserableness	1.6	2.7	3.4	1.7	1.7	1.4	1.7	1.7	1.9
Bipolar Disorder (2011)	1.5	1.5	1.7	1.3	1.2	1.3	1.2	1.2	1.1
Fasting Glucose	1.5	1.8	3.3	-1.0	-0.6	-1.7	-1.1	-1.3	-1.8
Reaction Time	1.4	2.7	3.4	-1.7	-1.7	-1.8	-1.4	-1.2	-1.9
Qualifications: CSEs or equivalent	1.4	1.9	3.0	-1.3	-1.7	-1.4	-1.2	-1.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.0	-1.6	-2.0	-1.2	-1.1	-1.3	-1.4
Had menopause	1.4	1.7	2.4	-1.4	-1.5	-0.6	-1.3	-1.3	-1.4
Emphysema/chronic bronchitis	1.4	1.6	3.2	-1.2	-0.7	-0.9	-1.3	-1.8	-1.4
Commuting to job workplace: Walk	1.4	1.5	2.2	1.5	1.2	1.3	1.3	1.2	0.9
Eye problems/disorders: Cataract	1.4	1.6	2.9	1.2	1.1	1.4	1.2	1.7	0.7
Serious illness, injury or assault to yourself	1.3	1.5	2.2	-1.1	-1.5	-1.1	-1.2	-1.2	-1.2
Diabetes (self-reported)	1.3	2.0	4.1	1.1	0.7	1.2	1.5	1.4	2.0
Peak expiratory flow (PEF)	1.3	3.0	6.5	-2.0	-2.5	-1.4	-1.4	-1.4	-1.3
Had major operations	1.3	1.5	2.6	1.3	1.0	0.7	1.6	1.3	1.3
Alzheimer’s Disease (including proxy)	1.2	1.7	2.3	-1.5	-1.3	-0.8	-1.3	-1.4	-1.3
Average weekly fortified wine intake	1.2	1.4	3.6	-1.3	-1.1	-1.1	-0.7	-0.7	-1.9
Pulse wave Arterial Stiffness index	1.2	1.4	2.2	-1.0	-0.9	-1.5	-1.5	-1.1	-0.7
Exposure to tobacco smoke outside home	1.2	1.6	2.1	1.3	1.4	1.5	1.4	0.7	1.2
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.8	1.3	1.7	0.9	0.7	1.5	0.9
Medication: Gliclazide	1.2	1.4	3.2	0.8	0.0	0.8	1.3	1.8	1.3
Commuting to job workplace: Public transport	1.2	1.4	2.9	0.9	0.7	1.7	1.3	1.3	1.0
Blood Eosinophil Count	1.1	8.7	14.1	3.0	3.8	2.6	3.1	2.7	2.3
Diabetes (mother)	1.1	1.4	1.8	1.3	1.4	1.1	1.2	1.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.8	-0.9	-1.1	-1.9	-1.3	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	5.0	-1.7	-2.2	-2.2	-1.9	-1.5	-1.7
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.8	0.8	0.8	1.7	0.9	0.5	1.6
Pulse wave peak to peak time	1.1	1.3	2.2	1.0	0.9	1.5	1.5	1.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.2	-1.1	-1.2	-0.5	-0.8	-1.2	-1.5
Qualifications: nursing, teaching	1.1	1.8	3.2	1.5	1.8	0.8	1.1	1.3	1.3
Hearing aid user	1.1	1.3	2.2	-1.2	-1.2	-0.8	-1.1	-0.8	-1.5
Coronary Artery Disease (CAD)	1.0	1.2	3.5	-0.9	-0.8	-0.7	-1.3	-1.9	-0.2
LDL Cholesterol	1.0	1.6	2.9	-1.1	-1.4	-1.7	-1.2	-1.3	-0.7
Taking other prescription medications	1.0	1.6	3.0	-1.3	-1.1	-1.3	-1.4	-1.7	-0.2
Medication: Ramipril	1.0	1.3	2.8	1.1	0.9	0.5	0.9	1.3	1.7
Falls in the last year	1.0	1.3	3.3	-1.2	-1.1	-0.5	-1.2	-1.8	-0.2
Tense / ‘highly strung’	1.0	1.6	2.8	-1.2	-1.0	-1.7	-1.2	-1.1	-1.3
Medication: Aspirin	1.0	1.3	3.1	-1.2	-0.7	-0.3	-0.8	-1.4	-1.8
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.6	-1.2	-1.2	-1.3	-0.5	-1.1	-1.0
Alzheimer’s Disease (in father)	0.9	0.9	1.7	-1.1	-0.8	-1.1	-1.3	-0.9	-0.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.2	0.9	0.9	1.3	0.2	0.2	1.5
Medication: Cholesterol lowering	0.9	1.4	2.4	-1.1	-1.0	-1.3	-1.2	-0.6	-1.6
Depression (self-reported)	0.9	1.0	1.5	-1.1	-1.0	-1.0	-1.1	-1.2	-0.6
Medication: Amlodipine	0.9	1.3	2.4	1.2	0.6	1.4	1.2	0.7	1.6
Ever had bowel cancer screening	0.9	1.0	1.5	1.1	1.0	0.6	0.8	1.1	1.2
Friendships satisfaction	0.9	1.1	1.7	-1.1	-0.1	-1.1	-1.3	-1.2	-1.1
Ovarian Cancer	0.8	1.1	1.4	-0.9	-1.2	-0.7	-1.0	-1.2	-1.1
Medication: Metformin	0.8	1.1	1.8	0.6	0.5	1.3	1.2	1.1	1.3
Mean Putamen Volume	0.7	0.8	2.2	1.1	0.7	-0.6	0.2	1.5	0.7
Rheumatoid Arthritis	0.7	0.9	1.4	1.1	0.7	0.5	0.9	1.2	1.2
Waist Hip Ratio (WHR)	0.7	3.0	4.5	1.9	2.1	1.9	1.3	1.1	1.8
Cardiovascular Disease	0.7	2.2	3.0	-1.6	-1.5	-1.2	-1.2	-1.7	-1.6
Chronic bronchitis/emphysema (father)	0.7	0.9	1.5	1.2	1.0	0.2	0.9	1.0	0.8
Time employed in main current job	0.7	0.8	1.4	-1.2	-0.7	-0.3	-1.0	-0.8	-1.0
Shortness of breath walking on level ground	0.7	0.9	1.7	0.7	1.0	0.3	1.2	1.3	0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.2	-0.9	-1.0	-0.8	-1.1	-0.1	-1.1
Supplements: Vitamin C	0.7	0.8	1.8	-1.0	-1.0	-0.7	-0.8	-1.3	-0.1
Age started oral contraceptive pill	0.7	0.9	1.8	-1.4	-0.9	-0.1	-0.7	-1.0	-1.1
Medication: Co-codamol	0.6	0.7	1.5	0.8	0.1	1.0	0.8	0.8	1.2
Relative age voice broke	0.6	0.9	1.9	0.7	0.5	1.4	1.1	0.5	1.1
Age when periods started (menarche)	0.6	1.3	2.3	-0.9	-1.3	-1.5	-1.1	-0.5	-1.2
Stomach or abdominal pain in last month	0.6	0.7	1.4	-0.7	-1.1	-0.7	-0.4	-1.2	-0.7
Qualifications: None of the above	0.6	1.3	2.2	-1.0	-1.1	-1.5	-1.2	-0.6	-1.2
Medication: Simvastatin	0.6	0.9	2.4	-0.9	-0.7	-0.7	-1.0	-0.6	-1.6
Breastfed as a baby	0.6	0.8	1.2	0.9	1.1	0.7	1.1	0.9	0.6
Medication: Paracetamol	0.6	0.9	1.5	-1.0	-1.1	-1.0	-1.2	-1.0	-0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	1.6	1.0	0.9	0.9	1.0	1.3	0.9
Neck or shoulder pain in last month	0.6	0.8	1.6	-0.9	-0.8	-1.2	-0.9	-0.6	-0.7
Pulse rate, automated reading	0.6	2.1	2.4	1.3	1.4	1.5	1.3	1.5	1.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.8	0.9	1.0	1.4	0.3	0.5	0.8
Diabetes diagnosed by doctor	0.6	0.9	1.5	0.7	0.3	1.0	1.2	0.9	1.2
Wears glasses or contact lenses	0.6	0.7	1.6	-1.0	-1.3	-0.3	0.1	-0.1	-1.2
Heart disease (siblings)	0.6	0.7	1.9	0.5	1.0	1.4	0.6	0.9	0.0
Crohns Disease (2017)	0.5	1.0	1.4	1.0	0.6	1.2	0.9	1.2	1.1
Blood clot in the leg (DVT)	0.5	0.6	2.2	0.6	0.5	0.4	0.7	1.5	0.4
Comparative body size at age 10	0.5	1.4	2.4	-1.3	-1.4	-1.5	-0.4	-0.3	-1.6
Wheeze or whistling in the chest in last year	0.5	0.9	2.9	0.8	1.7	0.5	0.7	0.6	0.9
Medication: Allopurinol	0.5	0.7	1.1	-0.9	-0.8	-0.6	-1.0	-0.6	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	-0.9	-0.5	-0.8	-0.9	-0.8	-0.5
Medication: Aspirin	0.5	0.6	1.5	-0.8	-0.3	0.0	-0.4	-1.1	-1.2
Loneliness, isolation	0.5	0.7	1.3	-1.1	-1.1	-0.8	-0.8	-0.2	-0.8
Mineral and other dietary supplements	0.5	0.6	1.7	0.8	1.3	0.5	0.7	0.6	0.6
Ever taken oral contraceptive pill	0.5	0.6	0.9	0.7	0.9	0.8	0.9	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.8	0.8	0.7	0.9	0.9	0.8	0.6
Age at First Birth	0.4	0.5	1.2	0.8	1.1	0.3	0.6	0.6	0.8
Ulcerative Colitis	0.4	0.5	0.9	0.8	0.7	0.2	0.8	0.5	0.9
Chronotype (morning person)	0.4	0.8	1.2	-0.9	-1.0	-0.7	-1.0	-0.9	-1.1
Hand grip strength (left)	0.4	1.1	2.0	-1.0	-1.1	-1.4	-1.0	-0.7	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-0.6	-0.2	1.0	-0.3	-1.0	-0.5
Medication: Atenolol	0.4	0.5	1.0	-0.8	-0.7	-0.3	-1.0	-0.8	-0.3
Impedance of leg (left)	0.4	1.8	2.3	-1.4	-1.3	-1.2	-1.3	-1.5	-1.3
Heart attack	0.4	0.5	1.2	-0.7	-0.7	-0.0	-0.4	-1.1	-0.6
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	-0.7	-0.6	-0.5	-0.9	-1.1	-0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	-0.7	-1.1	-0.4	-0.9	-0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.0	0.9	0.7	1.0	1.0	0.8	0.6
Birth weight	0.4	0.9	1.2	-1.0	-0.8	-0.8	-1.1	-0.8	-1.0
Angina (self-reported)	0.4	0.5	0.8	-0.8	-0.7	0.0	-0.5	-0.9	-0.8
Medication: Ibuprofen	0.4	0.5	2.0	-0.2	-0.5	-1.4	-0.9	0.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.7	-0.6	-0.7	-0.4	-0.0	0.0	-1.3
Long-standing illness, disability or infirmity	0.4	0.5	1.2	-1.0	-1.0	-0.0	-0.2	-1.1	-0.1
Medication: Blood pressure	0.4	0.7	1.4	-0.8	-1.0	-0.0	-1.2	-1.2	-0.1
Medication: Atorvastatin	0.4	0.5	1.0	-0.6	-1.0	-0.3	-0.5	-0.9	-0.6
Leg fat percentage (left)	0.4	1.5	2.0	-1.3	-0.8	-1.3	-1.4	-1.1	-1.3
Basal cell carcinoma (self-reported)	0.4	0.4	1.3	0.7	1.1	0.3	0.5	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	-0.8	-0.7	0.1	-0.4	-1.3	-0.5
Depression (Nagel 2018)	0.3	0.5	1.0	0.6	0.5	0.1	0.5	1.0	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	-0.5	-0.4	-0.0	-0.1	-0.7	-1.1
Allergy or Eczema	0.3	0.8	1.7	-0.8	-0.5	-1.1	-0.8	-1.3	-0.3
Relative age of first facial hair	0.3	0.5	1.0	-0.8	-1.0	-0.5	-0.3	-1.0	-0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	0.0	-0.1	1.1	0.6	-0.4	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	-0.6	-1.0	-0.4	0.2	0.4	-0.1
Angina	0.3	0.4	0.7	-0.8	-0.6	0.0	-0.5	-0.9	-0.7
Maternal smoking around birth	0.3	0.5	1.0	0.4	0.6	0.9	0.6	1.0	0.3
Supplements: Glucosamine	0.3	0.4	1.0	-0.8	-0.7	-0.1	-0.4	-1.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	0.5	0.3	0.5	0.8	0.5	0.8
Past tobacco smoking	0.3	0.5	0.9	-0.9	-0.5	-0.5	-0.7	-1.0	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	0.4	0.7	0.1	0.6	0.4	1.0
Father’s age at death	0.3	0.4	1.6	0.0	0.3	-1.2	-0.5	0.0	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.7	0.7	0.7	1.6	0.6	0.6	0.5
Exposure to tobacco smoke at home	0.3	0.4	1.3	0.3	0.6	1.2	0.4	0.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.8	-0.8	-0.9	-0.8	-0.5	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-0.4	-0.1	-0.4	-0.7	-1.1	0.1
Headache pain in last month	0.3	0.6	1.3	-0.9	-0.4	-0.5	-0.8	-1.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	0.6	0.6	1.0	0.6	0.9	0.5
Gout (self-reported)	0.3	0.5	1.2	-0.7	-0.6	-0.5	-1.1	-0.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.7	-0.5	0.2	-0.4	-1.2	-0.2
Overall health rating	0.3	0.6	1.7	-1.0	-1.3	-0.7	-0.4	0.2	-0.7
Chest pain or discomfort	0.3	0.4	0.7	-0.9	-0.3	-0.7	-0.6	-0.6	-0.7
Smoking status: Previous	0.3	0.4	1.3	0.8	0.3	0.2	0.7	1.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.9	-0.5	-0.8	-1.4	-0.4	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.6	-0.6	-0.1	-0.4	-0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.6	-0.6	-0.7	-1.3	-0.9	-0.7	-0.6
Illnesses of father: High blood pressure	0.3	0.4	0.9	0.6	0.6	0.9	0.5	0.4	0.6
Ever smoked	0.3	0.5	0.6	0.8	0.7	0.6	0.5	0.7	0.7
Number of operations (self-reported)	0.3	0.4	0.7	0.8	0.8	0.2	0.6	0.6	0.6
Diastolic blood pressure, automated reading	0.3	1.0	2.1	1.1	1.5	0.7	0.8	0.6	1.2
Commuting to job workplace: Cycle	0.3	0.4	1.3	0.3	0.6	1.1	0.6	0.3	0.2
Supplements: Calcium	0.3	0.4	0.9	-0.8	-1.0	-0.5	-0.4	-0.1	-0.4
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	0.9	0.4	0.4	0.7	0.8	0.7
Major Depression (MDD)	0.2	0.3	0.5	0.4	0.7	0.3	0.4	0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	-0.6	-0.3	-0.2	-0.7	-0.9	-0.7
Neuroticism (2016)	0.2	0.3	0.9	-0.4	-0.5	-1.0	-0.3	-0.4	-0.6
Triglycerides	0.2	0.4	0.7	0.8	0.6	-0.3	0.6	0.8	0.3
Blood White Count	0.2	1.6	2.8	1.0	1.7	1.0	1.6	1.4	0.7
Heel T-Score	0.2	1.3	2.9	-1.2	-1.3	-0.5	-0.7	-1.0	-1.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.6	0.6	0.7	0.8	0.4	0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.5	-0.2	-0.5	-0.6	-0.5	-0.8
Systolic blood pressure, automated reading	0.2	0.5	0.9	0.7	1.0	0.2	0.8	0.6	0.5
Vitamin and mineral supplements	0.2	0.3	1.0	0.5	0.6	-0.1	0.2	1.0	-0.1
Impedance of leg (right)	0.2	0.9	1.0	-1.0	-1.0	-1.0	-0.9	-0.9	-1.0
Waist circumference	0.2	0.7	1.5	0.8	1.2	0.8	0.5	0.7	0.7
Number of incorrect matches in round	0.2	0.3	0.5	0.3	0.7	0.4	0.5	-0.6	0.6
Nervous feelings	0.2	0.3	0.5	-0.7	-0.4	-0.7	-0.5	-0.5	-0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.5	-0.3	0.5	-0.7	-0.9	-0.2
Had other major operations	0.2	0.2	0.7	0.4	0.6	-0.2	0.8	0.3	0.1
Forced vital capacity (FVC)	0.2	0.8	1.3	1.2	0.9	0.2	0.9	1.1	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-0.6	-0.4	-0.6	-0.6	-1.1	-0.6
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.2	-0.8	-0.5	0.3	0.8	-0.1
Happiness	0.2	0.3	0.6	0.5	0.8	0.1	0.4	0.6	0.5
Asthma	0.2	0.4	1.0	0.4	0.9	0.2	1.0	0.4	0.6
Medication: Lansoprazole	0.2	0.2	0.4	-0.6	-0.2	0.2	-0.0	-0.6	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.3	-0.2	-1.1	-0.8	-0.3	-0.9
Birth weight of first child	0.2	0.3	1.2	-0.2	-0.4	-1.1	-0.1	0.2	-0.7
Leg fat percentage (right)	0.2	0.8	1.3	-0.9	-0.4	-1.1	-1.1	-0.7	-0.9
Worry too long after embarrassment	0.2	0.3	1.3	0.4	0.2	-0.1	0.1	1.1	0.2
Number of children fathered	0.2	0.2	0.6	-0.4	0.0	0.0	-0.8	-0.8	0.2
Age at first live birth	0.2	0.3	0.6	0.5	0.8	0.6	0.1	0.2	0.6
Qualifications: College or University degree	0.2	0.6	1.4	0.9	0.6	0.9	0.4	0.2	1.2
Migraine (self-reported)	0.2	0.2	0.8	-0.0	0.3	0.9	0.0	-0.3	0.5
Comparative height size at age 10	0.2	1.2	2.3	1.3	1.0	0.6	1.3	1.5	0.5
Number of full sisters	0.2	0.3	0.5	0.3	0.3	0.7	0.1	0.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	-0.5	-0.6	-0.2	-0.5	-0.5
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.0	-0.4	-0.7	0.0	0.7	-0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.9	0.5	0.7	1.0	0.1	0.3	0.3
Breast cancer (self-reported)	0.2	0.2	0.5	0.3	0.7	0.6	0.0	-0.1	0.4
Asthma (self-reported)	0.2	0.5	1.4	0.5	0.8	0.3	1.2	0.6	0.6
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.3	-0.3	-0.6	-0.8	-0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.0	-0.3	-1.0	-0.1	-0.3	-0.3	-0.0
Medication: Paracetamol	0.2	0.3	0.5	-0.6	-0.6	-0.4	-0.7	-0.5	0.0
Medication: Lisinopril	0.2	0.3	0.6	-0.4	-0.1	0.2	-0.6	-0.8	-0.7
Irritability	0.2	0.4	0.8	-0.7	-0.6	-0.3	-0.7	-0.6	-0.9
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.7	-0.8	-0.1	-0.3	-0.5	-0.4
Cholesterol lowering medication	0.2	0.3	0.6	-0.5	-0.7	0.0	-0.3	-0.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.3	0.2	0.5	0.7	-0.3	0.7
Bipolar Disorder (2018)	0.1	0.1	0.3	0.6	0.4	0.1	0.4	-0.1	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	1.0	0.2	0.4	-0.4	0.1	1.0	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.7	-0.2	0.0	-0.6	-0.6	-0.6
Neuroticism (Nagel 2018)	0.1	0.1	0.6	0.1	0.2	-0.5	0.0	0.8	0.0
Worry (Nagel 2018)	0.1	0.2	0.6	-0.4	-0.7	-0.8	-0.2	0.1	-0.3
Prostate Cancer	0.1	0.1	0.3	-0.1	-0.6	-0.4	0.3	0.2	-0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.4	0.2	-0.5	-0.2	-0.4	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.2	0.2	0.5	-0.2	-0.4	0.3
Schizophrenia (2014)	0.1	0.3	0.6	0.5	0.6	0.8	0.4	-0.3	0.4
Blood Platelet Count	0.1	1.3	3.2	1.1	1.8	1.1	0.9	0.3	1.1
Blood Red Count	0.1	0.8	1.6	0.7	1.2	0.7	0.6	1.3	0.4
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.0	0.1	-0.5	-0.7	-0.1	0.5
Lung FVC	0.1	0.6	1.2	-0.7	-1.1	-1.1	-0.6	-0.3	-0.7
Neuroticism	0.1	0.3	0.9	0.4	0.3	-0.4	0.4	1.0	0.1
Hair Pigment	0.1	4.0	5.5	-1.8	-2.0	-1.1	-2.2	-2.2	-2.3
Number of treatments/medications taken	0.1	0.2	0.2	-0.4	-0.5	-0.3	-0.5	-0.5	0.3
Sensitivity / hurt feelings	0.1	0.2	0.6	0.1	0.2	-0.6	0.2	0.8	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.0	0.0	0.0	0.5	0.4	0.2
Supplements: Zinc	0.1	0.1	0.2	-0.1	0.1	0.3	0.2	-0.4	0.5
Pack years adult smoking proportion	0.1	0.2	0.4	-0.6	-0.6	0.2	0.1	0.2	-0.4
Fed-up feelings	0.1	0.2	0.6	-0.4	-0.3	-0.8	-0.4	0.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.2	0.1	-0.5	-0.6	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	-0.5	-0.1	-0.4	-0.3	-0.5	-0.6
High blood pressure	0.1	0.2	0.4	-0.0	0.1	0.6	0.2	-0.6	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.0	-0.4	-0.2	-1.0	-0.4	-0.6	-0.1
Multivitamins +/- minerals	0.1	0.2	0.6	-0.2	0.0	0.5	-0.1	-0.8	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.3	0.1	0.3	-0.2	0.6	0.3
High blood pressure (mother)	0.1	0.1	0.4	-0.2	-0.2	0.2	-0.6	-0.5	0.4
Alcohol usually taken with meals	0.1	0.1	0.6	-0.0	0.1	-0.2	-0.3	-0.8	0.0
Hair/balding pattern: Pattern 2	0.1	0.2	0.9	0.2	-0.3	0.9	0.2	0.0	0.4
Mouth/teeth dental problems	0.1	0.2	0.4	0.4	0.1	0.3	0.6	0.6	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.7	0.3	0.8	-0.1	0.2	-0.1	0.4
Fluid intelligence score	0.1	0.2	0.6	0.4	0.8	0.7	0.1	-0.2	0.4
Illnesses of siblings	0.1	0.1	0.3	0.2	-0.3	-0.2	0.6	0.2	0.4
Hip circumference	0.1	0.5	1.0	0.6	1.0	0.1	0.6	1.0	0.1
Worrier / anxious feelings	0.1	0.2	0.4	0.1	-0.6	-0.4	0.4	0.5	0.0
Lung cancer (father)	0.1	0.1	0.5	0.1	-0.2	0.2	0.2	0.4	0.7
Illnesses of mother	0.1	0.2	0.4	0.2	0.1	-0.5	0.2	0.6	-0.4
Length of working week for main job	0.1	0.1	0.4	-0.4	-0.6	0.1	0.1	0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	0.5	0.5	0.3	-0.1	0.4	0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.0	0.6	0.6	0.3	-0.3	0.1
Forced vital capacity (FVC), Best measure	0.1	0.4	1.5	-0.1	-0.3	-1.2	-0.3	0.1	-0.7
Medication: Blood pressure	0.1	0.1	0.3	0.1	0.3	-0.4	0.1	-0.5	0.1
Medication: Omeprazole	0.1	0.1	0.4	0.2	-0.1	-0.3	0.6	0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	0.0	0.2	0.0	-0.5	-0.7	-0.0
Leg fat mass (right)	0.1	0.3	0.7	-0.4	-0.0	-0.9	-0.7	-0.2	-0.6
Alcohol intake frequency.	0.1	0.1	0.4	-0.1	0.3	-0.6	0.2	0.6	-0.2
Age at last live birth	0.1	0.2	0.5	-0.2	-0.5	0.7	0.4	0.5	0.2
Family relationship satisfaction	0.1	0.2	0.4	0.3	0.6	0.3	0.1	0.6	0.4
Hypertension (Self-reported)	0.1	0.3	0.6	0.2	0.2	0.8	0.4	-0.6	0.7
Medication for cholesterol	0.1	0.1	0.3	0.3	0.5	-0.1	0.0	0.3	0.6
Financial situation satisfaction	0.1	0.1	0.4	-0.6	-0.1	0.3	-0.2	-0.4	-0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.0	-0.3	0.3
Ever depressed for a whole week	0.1	0.2	0.4	-0.2	0.5	0.3	-0.4	-0.7	0.2
Myopia	0.1	0.2	0.9	0.4	-0.2	-0.1	0.3	1.0	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.4	0.6	0.5	-0.4	0.2	1.2	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.7	0.0	-0.0	-0.2	0.1	0.8	-0.1
Pack years of smoking	0.1	0.2	0.5	-0.1	-0.1	0.6	0.6	0.7	-0.0
Impedance of whole body	0.1	0.3	0.7	-0.5	-0.7	-0.4	-0.4	-0.8	-0.5
Leg fat mass (left)	0.1	0.4	0.8	-0.6	-0.2	-0.9	-0.9	-0.4	-0.7
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	0.3	0.3	0.5	0.1	-0.5	0.2
Schizophrenia (2018)	0.0	0.1	0.3	-0.0	0.0	0.5	-0.1	-0.6	-0.0
Ulcerative Colitis (UC)	0.0	0.1	0.4	0.1	-0.2	-0.6	-0.1	-0.1	-0.3
Breast Cancer	0.0	0.1	0.3	-0.2	-0.4	0.2	-0.1	-0.5	0.3
Crohns Disease (2012)	0.0	0.1	0.3	0.2	0.1	0.1	0.4	0.0	0.5
HbA1C	0.0	0.1	0.1	-0.1	0.1	-0.0	-0.3	-0.4	-0.3
BMI	0.0	0.3	0.5	0.5	0.7	0.2	0.2	0.6	0.6
Height	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.1	0.3	-0.2
Systolic Blood Pressure	0.0	0.1	0.2	0.1	0.4	-0.1	0.2	-0.3	0.1
Smoking Status	0.0	0.1	0.3	0.3	-0.3	-0.0	0.2	0.6	-0.2
Respiratory disease	0.0	0.1	0.4	-0.1	0.1	-0.2	0.6	-0.3	-0.1
Tanning	0.0	0.6	0.9	-0.8	-0.9	-0.9	-0.9	-0.5	-0.5
Average weekly spirits intake	0.0	0.1	0.2	-0.1	-0.0	-0.1	-0.4	-0.2	-0.3
Diabetes (father)	0.0	0.0	0.1	0.3	0.1	0.3	-0.2	0.1	-0.1
Leg fat-free mass (left)	0.0	0.2	0.5	0.3	0.5	-0.2	0.2	0.7	0.1
Trunk fat percentage	0.0	0.1	0.3	0.0	0.2	-0.6	-0.3	0.0	-0.2
Hand grip strength (right)	0.0	0.1	0.2	-0.0	-0.0	-0.2	-0.5	-0.3	-0.2
Current tobacco smoking	0.0	0.0	0.1	-0.1	-0.3	0.3	-0.0	0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.2	-0.1	-0.2	-0.3	0.1	0.4	-0.0
Sitting height	0.0	0.1	0.3	0.0	0.1	-0.2	0.5	0.6	0.1
Body mass index (BMI)	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3	-0.0	-0.2
Leg predicted mass (left)	0.0	0.2	0.6	0.5	0.6	-0.1	0.3	0.8	0.2
Trunk fat mass	0.0	0.2	0.7	-0.2	0.0	-0.8	-0.5	-0.1	-0.5
Allergy	0.0	0.1	0.2	0.0	-0.1	0.5	-0.2	-0.0	-0.1
Neuroticism score	0.0	0.1	0.3	-0.1	-0.2	-0.5	0.1	0.5	-0.2
Weight	0.0	0.1	0.1	-0.1	0.1	-0.4	-0.3	0.1	-0.3
Impedance of arm (right)	0.0	0.0	0.1	0.1	-0.3	-0.1	0.2	-0.1	0.1
Arm fat percentage (right)	0.0	0.1	0.2	0.3	0.5	-0.2	0.1	0.3	0.2
Trunk fat-free mass	0.0	0.1	0.1	-0.2	0.0	-0.4	-0.2	0.3	-0.4
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.1	0.4	0.2	0.1	0.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.6	-0.2	-0.8	-0.5	-0.2	-0.2	0.0
Pulse rate	0.0	0.0	0.0	-0.0	-0.2	0.2	-0.1	-0.2	0.2
Prospective memory result	0.0	0.1	0.1	0.4	0.1	0.3	-0.1	-0.1	0.3
Impedance of arm (left)	0.0	0.1	0.3	-0.1	-0.6	0.1	0.1	-0.3	0.0
Arm fat mass (right)	0.0	0.1	0.2	0.2	0.4	-0.3	-0.0	0.3	0.0
Trunk predicted mass	0.0	0.1	0.2	-0.2	-0.0	-0.4	-0.2	0.3	-0.4
Standing height	0.0	0.1	0.5	-0.2	-0.3	-0.7	-0.2	0.2	-0.3
Body fat percentage	0.0	0.2	0.5	-0.2	0.1	-0.7	-0.5	-0.2	-0.4
Arm fat-free mass (right)	0.0	0.2	0.4	-0.3	0.1	-0.7	-0.4	0.1	-0.6
Whole body fat mass	0.0	0.2	0.6	-0.2	0.2	-0.8	-0.5	-0.0	-0.4
Arm predicted mass (right)	0.0	0.2	0.6	-0.4	0.0	-0.7	-0.5	-0.0	-0.8
Whole body fat-free mass	0.0	0.1	0.2	0.0	0.3	-0.3	-0.0	0.4	-0.2
Leg fat-free mass (right)	0.0	0.2	0.4	0.5	0.6	-0.0	0.3	0.7	0.2
Arm fat percentage (left)	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.3	-0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	-0.4	-0.3	-0.3	-0.3	-0.1	-0.1
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.1	0.2	-0.1	0.2	-0.1	-0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.0	-0.2	0.3	0.2	-0.1	-0.0
Smoking status: Current	0.0	0.1	0.2	-0.2	-0.5	0.3	-0.1	-0.1	-0.1
Whole body water mass	0.0	0.1	0.3	0.2	0.4	-0.2	0.1	0.6	-0.0
Leg predicted mass (right)	0.0	0.2	0.4	0.5	0.5	-0.0	0.3	0.7	0.2
Arm fat mass (left)	0.0	0.0	0.1	0.1	0.3	-0.2	-0.2	0.1	-0.0
Guilty feelings	0.0	0.1	0.2	0.2	0.1	0.2	0.4	0.3	0.2
Basal metabolic rate	0.0	0.1	0.1	-0.0	0.2	-0.4	-0.1	0.4	-0.3
Arm fat-free mass (left)	0.0	0.1	0.3	-0.2	0.1	-0.5	-0.4	0.0	-0.4
Average weekly beer plus cider intake	0.0	0.0	0.0	-0.2	-0.0	-0.1	0.1	-0.1	-0.2
Arm predicted mass (left)	0.0	0.1	0.3	0.2	0.6	-0.3	0.0	0.6	0.1

Hub : Genes

SPINK5

Models

Trait associations