Hub : Genes

SPOP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.1374 0.0494 0.0045 0.005 NA 0.001 NA 0.001 0.1300 NA 0.2600 NA 0.2400
2 METSIM Adipose 0.0407 0.0201 0.0220 0.013 0.004 0.010 0.007 0.012 0.0036 0.062 0.0094 0.027 0.0052

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.8 1.5 1.2 -0.4
Bipolar Disorder or Schizophrenia 0.3 0.8 0.9 0.9 0.9
Depressed Affect (Nagel 2018) 0.3 0.5 0.6 -0.8 0.7
Depression (Nagel 2018) 0.3 0.4 0.5 -0.6 0.7
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.9 2.2 0.0
Neuroticism (Nagel 2018) 0.5 1.2 1.7 -1.3 0.8
Schizophrenia (2018) 0.5 1.0 2.1 -0.0 1.4
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.0 0.4
Worry (Nagel 2018) 0.8 1.6 1.6 -1.3 1.3
Alzheimer’s Disease (in mother) 1.2 1.4 2.5 -1.6 -0.5
Alzheimer’s Disease (in father) 2.1 2.3 4.3 -0.5 -2.1
Alzheimer’s Disease (including proxy) 1.9 2.8 3.6 -1.9 -1.4
Crohns Disease (2017) 1.4 3.0 6.0 -0.2 2.4
Irritable Bowel Disease (IBD) 1.1 2.6 5.2 -0.4 2.3
Ulcerative Colitis (UC) 0.9 1.6 2.9 -0.6 1.7
Major Depression (MDD) 0.0 0.0 0.0 0.2 0.2
Reaction Time 0.4 0.8 1.2 -1.1 0.6
Verbal and Numeric Reasoning (VNR) 0.7 1.8 2.7 1.6 -1.0
Breast Cancer 0.9 2.1 3.0 -1.1 -1.7
Ovarian Cancer 0.1 0.1 0.1 0.3 0.3
Prostate Cancer 0.2 0.3 0.5 0.7 0.0
Age at First Birth 1.4 2.0 4.0 0.1 -2.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.1 0.6 1.1
Coronary Artery Disease (CAD) 0.2 0.3 0.4 -0.4 0.7
Crohns Disease (2012) 0.0 0.0 0.1 -0.2 0.0
Mean Putamen Volume 0.7 0.8 1.1 0.7 1.0
Fasting Glucose 3.1 3.7 6.8 -2.6 -0.8
HbA1C 0.2 0.2 0.4 -0.6 0.2
HDL Cholesterol 0.1 0.2 0.3 0.3 0.5
LDL Cholesterol 1.2 1.8 3.7 -0.1 1.9
Lupus 0.6 0.9 1.7 -1.3 -0.4
Neuroticism (2016) 1.1 1.6 2.7 -0.7 1.6
Primary Biliary Cirrhosis 0.7 1.0 2.0 1.4 0.3
Rheumatoid Arthritis 0.4 0.6 1.2 -1.1 -0.0
Schizophrenia (2014) 0.2 0.5 1.1 0.1 1.0
Triglycerides 0.7 1.1 2.3 -0.1 1.5
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.9 -0.6 -0.9
Ulcerative Colitis 0.7 1.0 1.7 -0.5 1.3
Blood Eosinophil Count 0.4 3.0 6.0 0.3 2.4
Blood Platelet Count 0.9 10.0 15.5 2.1 3.9
Blood Red Count 1.0 9.3 18.3 -0.5 4.3
Blood White Count 0.2 1.3 2.3 -0.6 1.5
Heel T-Score 0.1 0.6 0.7 -0.6 -0.8
BMI 0.8 4.6 5.9 -1.8 2.4
Height 0.3 5.7 6.5 2.2 -2.5
Waist Hip Ratio (WHR) 1.0 4.5 9.0 -3.0 -0.2
Systolic Blood Pressure 0.8 4.0 6.0 -2.4 1.4
Smoking Status 0.0 0.0 0.0 -0.1 -0.0
Allergy or Eczema 4.9 13.0 25.5 -0.7 5.0
Cardiovascular Disease 0.2 0.8 1.2 -1.1 0.6
Hypothyroidism (self reported) 1.1 2.5 4.5 0.7 2.1
Respiratory disease 2.7 6.0 12.0 0.1 3.5
Type 2 Diabetes (T2D) (2018) 1.5 2.8 5.3 -2.3 -0.6
Lung FEV1/FVC ratio 2.8 14.3 25.6 -1.8 -5.1
Lung FVC 0.3 1.5 1.6 -1.3 1.2
Neuroticism 0.8 1.9 2.2 -1.2 1.5
Chronotype (morning person) 0.6 1.3 2.3 0.5 1.5
Hair Pigment 0.6 16.0 30.1 1.3 -5.5
Tanning 0.0 0.0 0.0 0.0 0.0
Hand grip strength (left) 0.3 0.7 1.4 1.2 0.3
Number of treatments/medications taken 1.5 2.6 3.8 -1.9 1.2
Average weekly spirits intake 0.5 0.7 0.9 -0.7 -0.9
Sensitivity / hurt feelings 2.0 3.5 6.5 -2.5 0.7
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 -0.3 0.5
Hearing difficulty/problems: Yes 1.2 1.8 2.7 -1.0 1.6
Relative age of first facial hair 0.0 0.0 0.1 0.1 -0.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 0.8 -0.9 0.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.5 -0.4 0.7
Ever had hysterectomy (womb removed) 0.9 1.0 1.7 -1.3 -0.5
Systolic blood pressure, automated reading 1.4 4.0 5.5 -1.6 2.3
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 1.7 -1.3 1.1
Angina 0.4 0.5 0.7 -0.5 -0.8
Medication for hormone replacement therapy 1.6 1.8 3.5 -1.9 0.3
Vitamin and mineral supplements 0.4 0.5 0.8 -0.5 -0.9
Supplements: Zinc 0.1 0.1 0.2 0.2 0.5
Medication: Co-codamol 0.0 0.0 0.0 -0.1 0.1
Medication: Metformin 2.4 3.5 6.5 -2.5 0.6
Diabetes (father) 0.3 0.4 0.7 0.0 0.8
Diabetes (mother) 0.4 0.5 0.9 -0.1 1.0
Severe depression (siblings) 0.3 0.4 0.7 0.8 0.3
Pack years adult smoking proportion 0.2 0.3 0.6 -0.8 0.3
Impedance of leg (right) 0.7 3.2 6.4 0.3 -2.5
Leg fat-free mass (left) 0.2 1.1 2.1 0.2 1.4
Trunk fat percentage 0.5 1.9 2.6 -1.6 1.1
Hand grip strength (right) 0.3 0.8 0.8 0.8 0.9
Townsend deprivation index at recruitment 1.5 2.1 4.1 0.3 -2.0
Current tobacco smoking 0.2 0.3 0.6 0.8 -0.1
Average weekly fortified wine intake 0.9 1.1 2.0 0.3 -1.4
Maternal smoking around birth 0.5 0.7 0.9 -0.9 -0.8
Fed-up feelings 1.9 3.4 5.3 -1.2 2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.8 2.1 -1.2 1.4
Relative age voice broke 0.2 0.3 0.5 -0.7 0.4
Taking other prescription medications 1.4 2.1 2.5 -1.6 1.3
Age when periods started (menarche) 1.0 2.3 3.0 -1.7 -1.3
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 3.2 -1.8 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 3.2 -1.8 -0.4
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 1.4 1.2 1.0
Qualifications: CSEs or equivalent 0.7 0.9 1.2 -1.1 0.7
Serious illness, injury or assault to yourself 1.0 1.2 2.3 -0.2 -1.5
High blood pressure 0.5 1.3 2.0 -1.4 -0.9
Hayfever, allergic rhinitis or eczema 3.9 8.6 16.2 -0.9 4.0
Multivitamins +/- minerals 0.4 0.5 1.0 1.0 -0.0
Stomach or abdominal pain in last month 1.9 2.3 3.4 -1.8 1.1
Supplements: Glucosamine 0.6 0.8 1.3 -0.5 -1.1
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.2 0.4 0.5
Medication: Atenolol 0.4 0.6 1.1 -1.0 -0.2
Medication: Levothyroxine sodium 0.3 0.4 0.8 0.3 0.9
Sitting height 0.7 4.9 8.0 2.8 -1.4
Chronic bronchitis/emphysema (father) 4.4 5.2 7.8 1.6 2.8
High blood pressure (mother) 1.0 1.4 1.5 -1.1 1.2
Body mass index (BMI) 1.0 4.1 5.6 -1.6 2.4
Impedance of leg (left) 0.8 3.9 7.8 -0.2 -2.8
Leg predicted mass (left) 0.2 1.2 2.3 0.3 1.5
Trunk fat mass 0.2 0.9 0.9 -0.9 1.0
Waist circumference 1.1 4.0 6.1 -2.5 1.3
Number of incorrect matches in round 0.8 1.4 1.5 -1.1 1.2
Past tobacco smoking 0.2 0.4 0.8 0.9 0.1
Alcohol usually taken with meals 1.6 2.5 5.0 0.3 -2.2
Nervous feelings 0.8 1.4 1.9 -1.4 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.1 -0.3 0.0
Hearing difficulty/problems with background noise 3.2 5.1 10.2 -3.2 -0.1
Hair/balding pattern: Pattern 2 1.2 1.5 2.5 -1.6 -0.7
Had menopause 0.1 0.1 0.3 -0.0 0.5
Had other major operations 0.3 0.4 0.7 0.9 0.1
Forced vital capacity (FVC) 0.2 0.9 1.8 0.2 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 3.3 -1.8 1.0
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 3.2 -1.8 0.8
Qualifications: None of the above 0.1 0.2 0.2 0.4 -0.4
Financial difficulties in last 2 years 1.2 1.6 2.4 0.9 -1.6
Mouth/teeth dental problems 1.0 1.6 2.4 1.6 0.8
Heart attack 0.2 0.2 0.5 -0.7 -0.1
Allergy 2.9 6.7 13.0 0.6 -3.6
Pain all over the body in last month 1.0 1.1 2.1 0.0 -1.5
Diabetes (self-reported) 2.5 3.9 6.8 -2.6 -1.0
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 6.4 0.0 2.5
Medication: Ramipril 0.7 0.9 1.6 -1.3 0.3
Medication: Simvastatin 3.6 5.3 10.5 -3.2 0.3
Fluid intelligence score 0.1 0.2 0.3 -0.5 -0.2
Illnesses of siblings 1.4 2.0 2.9 1.7 -1.1
Neuroticism score 1.4 2.9 3.4 -1.9 1.6
Weight 0.2 0.8 1.3 -0.6 1.1
Impedance of arm (right) 0.6 2.8 5.2 -0.7 -2.3
Arm fat percentage (right) 0.6 2.2 2.3 -1.5 1.5
Trunk fat-free mass 0.2 1.0 2.0 1.4 0.2
Hip circumference 0.2 0.9 1.6 -0.3 1.3
Time employed in main current job 3.5 4.0 4.2 1.9 2.1
Alcohol intake versus 10 years previously 1.9 2.9 2.9 -1.7 -1.7
Father’s age at death 0.7 1.0 1.5 1.2 -0.7
Worrier / anxious feelings 2.8 5.3 7.1 -2.7 1.9
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.4 3.8 -2.0 -1.7
Falls in the last year 0.7 1.0 1.6 -0.7 1.2
Hair/balding pattern: Pattern 3 0.4 0.5 0.8 -0.9 0.5
Number of live births 2.4 3.3 6.4 -2.5 -0.5
Forced expiratory volume in 1-second (FEV1) 0.0 0.2 0.2 -0.4 0.4
Pulse rate 1.3 2.2 2.7 1.3 -1.6
Happiness 1.0 1.2 2.1 0.5 1.4
Noisy workplace 0.7 0.8 1.3 -1.2 -0.6
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.0 0.0 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.6 -0.0
Mouth/teeth dental problems: Dentures 0.4 0.6 1.3 1.1 0.1
Asthma 1.3 2.6 5.1 -0.3 2.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 0.9 1.0 0.7
Medication: Cholesterol lowering 1.4 2.2 4.4 -2.1 -0.1
Depression (self-reported) 1.2 1.5 2.2 -0.9 1.5
Medication: Lansoprazole 1.6 1.8 3.2 -1.8 0.6
Prospective memory result 0.6 0.7 1.1 0.6 -1.0
Lung cancer (father) 0.4 0.5 0.9 0.9 -0.4
Illnesses of mother 1.0 1.3 2.4 1.6 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.1 0.1 -0.3
Pulse wave Arterial Stiffness index 0.0 0.0 0.1 -0.0 -0.3
Impedance of arm (left) 0.3 1.3 2.1 -0.7 -1.4
Arm fat mass (right) 0.4 1.5 2.2 -0.8 1.5
Trunk predicted mass 0.2 1.1 2.2 1.5 0.2
Standing height 0.6 5.7 6.6 2.6 -2.2
Length of working week for main job 1.4 1.6 1.8 1.3 1.2
Exposure to tobacco smoke at home 1.5 1.6 3.2 -1.8 0.4
Breastfed as a baby 1.2 1.5 3.0 1.7 -0.1
Tense / ‘highly strung’ 1.1 1.8 2.6 1.0 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.0 -0.2 1.0
Hair/balding pattern: Pattern 4 0.2 0.5 0.9 0.9 -0.1
Birth weight of first child 0.7 1.3 2.6 -1.6 -0.2
Peak expiratory flow (PEF) 0.5 1.2 1.3 -1.1 -1.1
Pulse wave reflection index 0.6 0.8 1.0 -1.0 -0.7
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.0 1.0 0.0
Loud music exposure frequency 0.9 1.0 1.8 1.3 0.4
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.6 -1.6 -0.8
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 3.5 -0.5 -1.9
Blood clot in the leg (DVT) 1.0 1.3 2.5 0.4 -1.6
Medication: Paracetamol 0.4 0.6 1.2 -1.1 0.1
Headache pain in last month 0.8 1.4 2.7 0.1 1.6
Medication for cholesterol, blood pressure or diabetes 0.8 1.2 1.7 1.3 0.9
Glaucoma (self-reported) 0.7 0.9 1.7 0.1 -1.3
Gout (self-reported) 0.2 0.3 0.4 -0.4 -0.6
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.2 0.8 1.1
Medication: Amlodipine 1.0 1.4 2.5 -1.6 0.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 0.9 0.3
Birth weight 0.0 0.0 0.0 -0.0 0.1
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.3 -0.2
High blood pressure (siblings) 2.2 3.1 6.2 -2.5 0.4
Forced vital capacity (FVC), Best measure 0.1 0.2 0.3 0.6 0.4
Body fat percentage 0.5 2.1 2.4 -1.6 1.3
Leg fat percentage (right) 0.5 1.9 3.3 -0.7 1.8
Arm fat-free mass (right) 0.2 1.0 1.2 0.9 1.1
Exposure to tobacco smoke outside home 2.3 3.0 5.7 -2.4 0.6
Comparative body size at age 10 0.1 0.4 0.7 0.9 -0.2
Number of full brothers 1.3 1.6 2.0 -1.4 -1.1
Worry too long after embarrassment 2.4 4.0 6.3 -2.5 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 0.7 0.7 -0.9
Wheeze or whistling in the chest in last year 0.3 0.5 0.9 -0.3 1.0
Number of children fathered 0.6 0.7 1.4 1.2 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.2 0.5 -0.4
Age at first live birth 1.6 2.8 3.9 2.0 -1.3
Pulse wave peak to peak time 0.0 0.0 0.0 0.1 0.2
Health satisfaction 1.2 1.6 1.9 -1.2 1.4
Shortness of breath walking on level ground 1.8 2.2 4.2 -0.4 2.0
Qualifications: College or University degree 0.4 1.2 1.7 0.8 -1.3
Eye problems/disorders: None of the above 0.0 0.1 0.1 0.3 -0.2
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.8 -0.9 0.3
Emphysema/chronic bronchitis 0.6 0.7 0.8 -0.9 0.7
Medication for pain relief, constipation, heartburn 2.2 3.7 3.9 1.9 -2.0
Neck or shoulder pain in last month 0.1 0.1 0.1 0.2 0.3
Medication: Blood pressure 0.6 1.1 1.7 -1.3 -0.7
Angina (self-reported) 0.5 0.7 1.3 -0.4 -1.1
Migraine (self-reported) 0.4 0.5 1.1 0.1 1.0
Medication: Ibuprofen 0.2 0.2 0.4 0.6 0.3
Medication: Allopurinol 0.2 0.3 0.4 -0.6 0.4
Medication: Omeprazole 0.3 0.3 0.6 -0.2 0.8
Medication: Seretide 50 evohaler 0.9 1.1 1.4 1.2 0.9
Mean time to correctly identify matches 0.3 0.6 1.0 -1.0 0.4
Heart disease (mother) 0.6 0.7 1.4 -1.2 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.7 -0.2 0.9
Whole body fat mass 0.3 1.4 1.8 -1.0 1.3
Leg fat mass (right) 0.4 1.5 2.7 -0.4 1.6
Arm predicted mass (right) 0.1 0.7 0.8 0.9 0.8
Pulse rate, automated reading 0.0 0.2 0.3 0.5 -0.2
Alcohol intake frequency. 0.8 1.8 2.2 -1.5 1.2
Comparative height size at age 10 0.2 1.3 2.6 1.6 -0.1
Number of full sisters 0.2 0.2 0.3 -0.6 0.3
Suffer from ‘nerves’ 0.2 0.3 0.4 -0.4 0.7
Overall health rating 0.8 1.8 3.4 -1.8 0.4
Chest pain or discomfort 0.0 0.0 0.1 0.2 0.1
Had major operations 1.2 1.4 2.2 -1.5 0.7
Age at last live birth 1.0 1.5 1.9 1.4 -1.0
Family relationship satisfaction 0.6 0.7 1.3 -0.4 1.1
Leg pain on walking 0.2 0.3 0.4 -0.6 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.7 0.8 -0.1
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.1 0.2 -0.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.1 -1.4 1.1
Medication: Aspirin 2.0 2.7 5.3 -2.3 0.3
Supplements: Vitamin C 0.7 0.9 1.7 -0.2 1.3
Knee pain experienced in last month 1.3 2.0 3.8 -1.9 0.5
Hypertension (Self-reported) 0.4 1.1 1.3 -1.2 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.6 5.0 -2.2 0.5
Illnesses of father: Heart disease 1.3 1.8 3.7 -0.1 1.9
Illnesses of siblings: Diabetes 1.5 1.9 3.7 -1.9 -0.3
Smoking status: Previous 0.5 0.8 1.5 -1.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.6 1.3 -0.7
Whole body fat-free mass 0.1 0.7 0.7 0.9 0.8
Leg fat-free mass (right) 0.1 0.8 1.5 0.0 1.2
Arm fat percentage (left) 0.8 3.2 3.6 -1.6 1.9
Average weekly red wine intake 0.4 0.6 1.0 1.0 0.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.6 -0.4 -1.2
Mood swings 0.1 0.2 0.3 -0.1 0.6
Loneliness, isolation 0.3 0.4 0.5 -0.7 0.6
Long-standing illness, disability or infirmity 0.3 0.5 0.9 -0.9 0.4
Ever had bowel cancer screening 0.5 0.6 1.1 1.1 0.4
Diabetes diagnosed by doctor 2.0 3.4 5.9 -2.4 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.5 -0.5 1.6
Friendships satisfaction 0.9 1.1 2.1 -1.4 0.4
Qualifications: nursing, teaching 0.2 0.2 0.4 -0.3 -0.6
Commuting to job workplace: Walk 0.8 0.9 1.8 0.0 1.3
Eye problems/disorders: Cataract 0.1 0.1 0.2 -0.0 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.3 -1.1 -0.7
Medication for cholesterol 2.0 3.0 6.0 2.4 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.2 -1.5 -0.7
Back pain experienced in last month 1.7 2.5 4.9 -2.2 -0.2
Mineral and other dietary supplements 0.7 1.0 1.7 -0.5 1.3
Breast cancer (self-reported) 0.1 0.1 0.2 -0.5 0.1
Asthma (self-reported) 1.3 2.6 5.2 0.2 2.3
Osteoporosis (self-reported) 1.1 1.3 2.5 1.6 0.4
Osteoarthritis (self-reported) 1.1 1.4 2.5 -0.6 1.6
Medication: Aspirin 1.6 2.1 4.1 -2.0 0.0
Medication: Gliclazide 0.8 0.9 1.1 -1.1 -0.8
Illnesses of father: None of the above (group 1) 2.4 3.0 5.9 -0.4 -2.4
Smoking status: Current 0.3 0.5 0.8 0.9 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.8 0.0 -0.9
Whole body water mass 0.1 0.8 0.9 0.9 0.8
Leg predicted mass (right) 0.1 0.8 1.6 0.1 1.3
Arm fat mass (left) 0.6 2.4 3.3 -1.2 1.8
Number of self-reported non-cancer illnesses 0.3 0.6 1.0 -1.0 0.5
Average weekly champagne plus white wine intake 0.3 0.4 0.9 0.1 -0.9
Miserableness 0.7 1.2 2.1 -1.4 0.6
Guilty feelings 0.4 0.6 1.1 0.4 1.0
Wears glasses or contact lenses 0.7 0.8 1.7 1.3 -0.1
Ever taken oral contraceptive pill 1.6 1.8 2.4 -1.5 1.1
Hearing aid user 1.3 1.5 2.0 1.0 1.4
Mother’s age at death 1.0 1.2 1.9 1.4 -0.7
Financial situation satisfaction 0.2 0.2 0.3 0.3 0.5
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.8 0.2 0.9
Commuting to job workplace: Public transport 0.2 0.2 0.2 -0.4 -0.5
Eye problems/disorders: Glaucoma 1.2 1.4 2.9 0.1 -1.7
Medication: Blood pressure 1.1 2.0 3.9 -2.0 -0.4
Pain type(s) experienced in last month: Hip pain 3.5 4.4 7.4 -2.7 1.2
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.7 0.6 -1.3
High cholesterol (Self-reported) 1.7 3.0 5.9 -2.4 0.2
Medication: Bendroflumethiazide 3.5 5.4 8.8 -3.0 -1.4
Medication: Paracetamol 0.2 0.3 0.4 -0.7 -0.3
Medication: Lisinopril 0.6 0.8 1.6 -1.3 -0.0
Medication: Atorvastatin 0.3 0.4 0.5 -0.7 -0.5
Illnesses of father: High blood pressure 1.8 2.2 4.1 -0.5 2.0
Alcohol drinker status: Never 0.4 0.4 0.7 0.4 0.8
Ever smoked 0.0 0.0 0.0 -0.1 -0.0
Basal metabolic rate 0.1 0.4 0.7 0.4 0.9
Leg fat percentage (left) 0.5 1.6 2.2 -1.0 1.5
Arm fat-free mass (left) 0.1 0.4 0.6 0.8 0.5
Number of operations (self-reported) 0.8 1.2 1.5 -0.9 -1.2
Average weekly beer plus cider intake 0.6 0.9 1.4 -0.7 1.2
Irritability 0.7 1.1 1.4 -0.9 1.2
Risk taking 2.2 3.2 3.7 1.6 -1.9
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.3 0.2
Fractured/broken bones in last 5 years 0.1 0.1 0.1 -0.3 -0.4
Age started oral contraceptive pill 0.5 0.6 0.7 -0.7 -0.8
Diastolic blood pressure, automated reading 2.1 6.4 12.0 -0.9 3.5
Ever depressed for a whole week 1.5 1.8 2.9 -0.9 1.7
Unable to work because of sickness or disability 0.2 0.3 0.5 -0.7 0.3
Commuting to job workplace: Cycle 0.6 0.7 1.0 -1.0 -0.7
Myopia 0.4 0.6 0.7 0.6 -0.8
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.5 1.6 0.7
Cholesterol lowering medication 1.2 1.8 3.5 -1.9 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.6 -0.0 0.8
Pain experienced in last month 3.0 5.0 8.4 2.9 -1.2
Supplements: Calcium 0.0 0.0 0.0 -0.2 -0.0
Basal cell carcinoma (self-reported) 0.6 0.8 1.3 1.1 0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 -0.6 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.2 0.4 -1.5
Heart disease (siblings) 0.2 0.2 0.2 0.5 -0.4
Alcohol drinker status: Previous 2.0 2.3 2.3 -1.5 1.5
Pack years of smoking 0.4 0.6 1.0 -1.0 0.4
Impedance of whole body 0.5 2.5 4.8 -0.4 -2.2
Leg fat mass (left) 0.4 1.4 2.2 -0.8 1.5
Arm predicted mass (left) 0.1 0.3 0.3 0.6 0.6