TWAS hub - SPRED2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Soft Tissue Sarcoma	0.057	0.035	0.0060	0.015	0.024	0.015	NA	0.009	0.042	0.013	0.0430	NA	0.090
2	TCGA	Testicular Germ Cell Tumors	0.206	0.094	0.0055	0.037	0.013	0.050	NA	0.016	0.019	0.110	0.0073	NA	0.089

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Rheumatoid Arthritis	7.5	10.3	17.2	-4.2	1.8
Other serious medical condition/disability diagnosed by doctor	6.2	8.0	8.1	2.8	-2.9
Eye problems/disorders: Glaucoma	5.9	7.0	9.7	3.1	-2.1
Smoking status: Previous	5.3	7.9	13.3	-3.7	1.5
Blood clot in the leg (DVT)	4.7	6.1	8.8	3.0	-1.9
Illnesses of siblings: Diabetes	4.5	5.5	8.1	2.8	-1.7
Deep venous thrombosis (DVT) (self-reported)	4.5	5.8	10.0	3.2	-1.3
Alcohol drinker status: Previous	4.2	4.7	6.2	-2.5	1.8
Hand grip strength (left)	4.1	10.9	19.2	4.4	-1.6
Medication: Atorvastatin	4.0	4.9	7.3	1.6	-2.7
Hearing aid user	3.9	4.4	5.4	-2.3	1.8
Blood White Count	3.8	28.3	46.2	-6.8	3.2
Pulse wave Arterial Stiffness index	3.8	4.4	8.7	3.0	-0.4
Pulse wave peak to peak time	3.5	4.2	7.9	-2.8	0.6
Illness, injury, bereavement, stress in last 2 years	3.5	4.3	5.8	-2.4	1.7
Time employed in main current job	3.3	3.8	7.2	2.7	-0.6
Breast cancer (self-reported)	3.2	3.9	4.3	2.1	-1.9
Glaucoma (self-reported)	3.1	3.6	5.7	2.4	-1.3
Health satisfaction	3.1	4.1	7.6	2.8	-0.7
Chest pain or discomfort	3.1	4.5	5.0	2.0	-2.2
Mouth/teeth dental problems: Loose teeth	2.9	3.4	6.9	0.2	-2.6
Past tobacco smoking	2.8	5.1	9.6	3.1	-0.8
Type 2 Diabetes (T2D) (2018)	2.7	5.0	9.8	3.1	-0.5
Blood Eosinophil Count	2.6	19.8	38.8	-6.2	-0.9
Hand grip strength (right)	2.6	6.9	13.3	3.6	-0.8
Eye problems/disorders: None of the above	2.5	2.9	5.7	-2.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	5.8	2.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	2.8	1.6	-1.7
Depression (Nagel 2018)	2.4	3.7	5.5	2.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	4.5	2.1	-1.7
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	4.8	2.2	-0.7
Allergy or Eczema	2.2	5.9	7.8	-2.0	2.8
Taking other prescription medications	2.2	3.4	4.8	1.4	-2.2
Medication: Atenolol	2.2	2.7	4.2	2.1	-1.1
Ever highly irritable/argumentative for 2 days	2.1	2.5	4.7	0.6	-2.2
Alcohol intake frequency.	2.1	4.8	9.5	0.2	3.1
Age started oral contraceptive pill	2.1	2.6	3.0	1.5	-1.7
Fed-up feelings	2.0	3.7	7.2	0.5	-2.7
Qualifications: A levels/AS levels or equivalent	2.0	4.3	6.1	2.5	-1.6
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	6.2	-2.5	-0.5
Ever smoked	2.0	3.6	6.6	-2.6	0.7
Body Mass Index (BMI) (2010)	1.9	2.6	3.7	-1.9	1.3
Qualifications: CSEs or equivalent	1.9	2.5	4.6	-0.6	2.1
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	5.9	2.4	0.0
Diabetes diagnosed by doctor	1.9	3.1	3.8	1.9	-1.6
Bipolar Disorder (2018)	1.8	2.9	3.8	-1.4	1.9
Irritable Bowel Disease (IBD)	1.8	4.2	8.4	2.9	-0.2
Heart attack	1.8	2.3	3.4	1.1	-1.8
Happiness	1.8	2.2	3.1	1.8	-1.1
Exposure to tobacco smoke at home	1.8	2.0	3.0	1.0	-1.7
Illnesses of siblings	1.7	2.4	3.7	-1.9	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	2.9	1.7	-1.6
Medication: Lansoprazole	1.7	1.9	3.6	1.9	-0.5
Overall health rating	1.7	3.7	4.9	1.6	-2.2
Heart attack/myocardial infarction (self-reported)	1.7	2.2	3.6	0.9	-1.9
Bipolar Disorder or Schizophrenia	1.6	3.9	6.5	-1.1	2.5
Major Depression (MDD)	1.6	1.9	3.6	0.4	-1.9
HbA1C	1.6	1.7	2.2	-1.5	1.1
Medication: Co-codamol	1.6	1.9	2.1	1.5	-1.3
Age when periods started (menarche)	1.6	3.9	4.9	2.2	1.7
Diabetes (self-reported)	1.6	2.4	3.9	2.0	-1.0
Lung cancer (father)	1.6	1.9	2.3	1.5	-1.2
Hair/balding pattern: Pattern 4	1.6	3.8	5.4	-1.5	2.3
Supplements: Vitamin C	1.6	1.9	3.8	-1.9	-0.1
Long-standing illness, disability or infirmity	1.6	2.4	2.5	1.5	-1.6
Unable to work because of sickness or disability	1.6	2.0	3.6	-0.7	-1.9
Financial difficulties in last 2 years	1.5	2.0	3.1	1.8	-1.0
Back pain experienced in last month	1.5	2.2	3.0	1.7	-1.2
Supplements: Glucosamine	1.4	1.8	3.1	-0.7	1.8
Emphysema/chronic bronchitis	1.4	1.6	2.9	0.5	-1.7
Medication: Gliclazide	1.4	1.6	2.2	1.0	-1.5
Ever depressed for a whole week	1.4	1.7	2.8	0.7	-1.7
Alzheimer’s Disease (in father)	1.3	1.5	2.8	0.4	-1.7
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	2.2	0.9	-1.5
Mouth/teeth dental problems: Dentures	1.3	2.2	3.3	-1.0	1.8
Loud music exposure frequency	1.3	1.4	2.7	0.1	-1.6
Angina (self-reported)	1.3	1.8	3.0	1.7	-0.8
Friendships satisfaction	1.3	1.6	2.3	1.5	-0.9
Eye problems/disorders: Cataract	1.3	1.5	3.0	1.7	-0.1
Mother’s age at death	1.3	1.6	2.3	0.9	-1.5
Crohns Disease (2017)	1.2	2.7	5.4	2.3	0.1
Ulcerative Colitis (UC)	1.2	2.2	4.5	2.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.1	1.5	-1.1
Medication: Simvastatin	1.2	1.8	2.5	1.1	1.6
Osteoarthritis (self-reported)	1.2	1.5	3.0	1.7	-0.3
Breast Cancer	1.1	2.7	5.4	0.2	2.3
Crohns Disease (2012)	1.1	1.8	3.1	1.8	0.6
Ulcerative Colitis	1.1	1.5	3.1	1.8	0.1
Average weekly spirits intake	1.1	1.4	2.7	1.6	0.2
Had menopause	1.1	1.4	1.9	1.0	-1.4
Mean time to correctly identify matches	1.1	2.0	3.6	-1.9	0.7
Ever taken oral contraceptive pill	1.1	1.2	1.6	-0.9	-1.3
Financial situation satisfaction	1.1	1.3	1.5	1.1	-1.2
High cholesterol (Self-reported)	1.1	1.9	1.9	1.4	1.4
Alcohol drinker status: Never	1.1	1.3	1.6	1.0	1.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.4	-0.4	1.5
Alzheimer’s Disease (in mother)	1.0	1.2	2.0	-1.4	0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.2	1.8	1.3	-0.8
Angina	1.0	1.4	2.3	1.5	-0.7
Diabetes (father)	1.0	1.2	1.4	1.0	-1.2
Medication: Levothyroxine sodium	1.0	1.6	2.6	0.8	-1.6
Hair/balding pattern: Pattern 2	1.0	1.2	1.6	1.3	-0.9
Birth weight	1.0	2.1	4.2	2.0	0.3
Age at first live birth	1.0	1.8	2.0	1.2	-1.4
Heart disease (mother)	1.0	1.2	2.0	0.6	-1.4
Depressed Affect (Nagel 2018)	0.9	1.9	3.1	0.9	-1.8
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.7	0.9	-1.3
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.0	-1.4	-0.6
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	1.4	-0.3
Supplements: Zinc	0.9	1.0	1.1	-1.0	1.1
Severe depression (siblings)	0.9	1.0	1.5	0.7	-1.2
Townsend deprivation index at recruitment	0.9	1.2	2.3	-0.4	-1.5
Prospective memory result	0.9	1.1	1.5	-1.2	0.9
Pulse rate, automated reading	0.9	2.9	5.3	-2.3	-0.6
Medication for cholesterol	0.9	1.4	1.4	-1.1	1.2
Wears glasses or contact lenses	0.9	1.0	1.3	-0.9	-1.1
Systolic Blood Pressure	0.8	4.2	7.0	2.6	-1.2
Current tobacco smoking	0.8	1.2	1.7	0.9	-1.3
Hayfever, allergic rhinitis or eczema	0.8	1.8	1.9	-1.3	1.4
Number of incorrect matches in round	0.8	1.3	2.2	0.6	-1.5
Irritability	0.8	1.3	2.2	-1.5	-0.7
Schizophrenia (2018)	0.7	1.5	2.9	-0.3	1.7
Schizophrenia vs Biploar Disorder	0.7	1.0	2.0	0.1	-1.4
LDL Cholesterol	0.7	1.2	1.4	1.2	1.0
Primary Biliary Cirrhosis	0.7	0.9	1.9	1.4	0.0
Triglycerides	0.7	1.1	2.1	1.5	-0.4
Heel T-Score	0.7	5.3	8.2	2.9	-1.6
Smoking Status	0.7	1.6	3.1	-1.8	-0.4
Lung FEV1/FVC ratio	0.7	3.8	7.3	-2.7	0.4
Medication: Metformin	0.7	1.0	1.6	1.3	-0.6
Serious illness, injury or assault to yourself	0.7	0.9	1.0	1.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	0.6	-1.2
Headache pain in last month	0.7	1.1	2.2	1.5	-0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.2	1.1	0.8
Comparative body size at age 10	0.7	1.8	3.6	1.9	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	-0.3	-1.3
Suffer from ‘nerves’	0.7	1.1	1.1	1.0	1.0
Risk taking	0.7	1.0	1.9	-1.4	0.1
Cholesterol lowering medication	0.7	1.0	1.6	0.7	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	1.4	1.1	1.2
Height	0.6	12.0	22.2	4.7	1.4
Hearing difficulty/problems with background noise	0.6	1.0	1.5	-1.2	-0.8
Trunk fat-free mass	0.6	3.5	5.9	2.4	1.0
Hair/balding pattern: Pattern 3	0.6	0.9	1.5	-1.2	-0.6
Trunk predicted mass	0.6	3.5	5.9	2.4	1.1
Standing height	0.6	5.5	7.6	2.8	1.8
Length of working week for main job	0.6	0.7	1.4	0.1	1.2
Medication: Amlodipine	0.6	0.8	1.2	-0.6	-1.1
Leg fat percentage (right)	0.6	2.3	4.4	-2.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-1.2	0.1
Qualifications: College or University degree	0.6	1.8	2.9	-1.7	0.8
Migraine (self-reported)	0.6	0.7	0.9	0.7	1.0
Age at last live birth	0.6	0.8	1.7	-0.2	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.7	1.3	1.0
Average weekly red wine intake	0.6	0.9	1.8	-0.3	1.3
Smoking status: Current	0.6	0.9	1.6	0.5	-1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.1	-0.5	-1.0
Leg fat percentage (left)	0.6	2.1	3.7	-1.9	-0.7
Commuting to job workplace: Cycle	0.6	0.7	1.0	-0.7	1.0
Heart disease (siblings)	0.6	0.7	1.2	0.4	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.5	1.6	1.2	1.3
Hearing difficulty/problems: Yes	0.5	0.7	1.3	-1.1	0.3
Medication for hormone replacement therapy	0.5	0.5	0.8	-0.5	-0.9
Fluid intelligence score	0.5	1.0	1.7	1.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.7	-0.8	-0.8
Medication: Cholesterol lowering	0.5	0.7	1.4	1.2	-0.2
Number of children fathered	0.5	0.5	1.1	1.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	1.0	-0.6
Medication: Aspirin	0.5	0.7	1.3	1.1	0.2
Whole body fat-free mass	0.5	2.8	4.9	2.2	0.9
Leg fat-free mass (right)	0.5	2.5	3.8	1.9	1.1
Mineral and other dietary supplements	0.5	0.7	1.0	0.5	-1.0
Osteoporosis (self-reported)	0.5	0.6	1.0	0.4	-1.0
Medication: Aspirin	0.5	0.7	1.0	1.0	0.6
Whole body water mass	0.5	2.7	4.5	2.1	1.0
Leg predicted mass (right)	0.5	2.6	3.9	2.0	1.2
Number of self-reported non-cancer illnesses	0.5	0.8	1.3	1.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.1	-1.0	0.5
Medication: Paracetamol	0.5	0.8	1.4	-1.2	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	0.7	-0.7	-0.8
Prostate Cancer	0.4	0.5	0.8	-0.9	-0.5
Mean Putamen Volume	0.4	0.4	0.7	-0.9	-0.3
Blood Platelet Count	0.4	5.2	8.1	-2.9	1.5
Lung FVC	0.4	2.1	3.6	0.8	-1.9
Chronotype (morning person)	0.4	0.9	1.2	-0.7	1.1
Impedance of leg (right)	0.4	1.7	2.2	-1.5	-1.1
Leg fat-free mass (left)	0.4	2.3	2.8	1.7	1.3
Multivitamins +/- minerals	0.4	0.6	1.1	1.1	0.1
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	-0.9	0.0
Impedance of leg (left)	0.4	2.0	2.1	-1.4	-1.5
Leg predicted mass (left)	0.4	2.2	2.8	1.7	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	0.7	-0.8	-0.6
Pain all over the body in last month	0.4	0.4	0.8	-0.9	-0.1
Father’s age at death	0.4	0.6	1.0	-1.0	0.4
Worrier / anxious feelings	0.4	0.8	1.0	-1.0	0.8
Noisy workplace	0.4	0.5	0.8	0.4	-0.9
Illnesses of mother	0.4	0.5	0.7	-0.5	-0.9
Breastfed as a baby	0.4	0.5	0.8	-0.4	0.9
Birth weight of first child	0.4	0.8	0.8	-0.8	0.9
Peak expiratory flow (PEF)	0.4	0.8	0.9	0.9	-0.9
Medication: Paracetamol	0.4	0.6	1.2	-1.1	0.2
High blood pressure (siblings)	0.4	0.5	0.8	0.5	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	3.0	1.7	0.4
Arm fat-free mass (right)	0.4	2.1	4.2	2.1	0.2
Medication: Seretide 50 evohaler	0.4	0.4	0.9	-0.1	-0.9
Arm predicted mass (right)	0.4	2.1	3.9	2.0	0.6
Family relationship satisfaction	0.4	0.4	0.4	0.7	-0.7
Mood swings	0.4	0.7	1.5	0.0	-1.2
Loneliness, isolation	0.4	0.6	0.8	-0.7	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.5	-0.6	0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	0.9	0.4
Basal metabolic rate	0.4	2.0	3.1	1.8	0.9
Average weekly beer plus cider intake	0.4	0.6	0.7	-0.6	0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.0	-1.0	0.1
Reaction Time	0.3	0.7	1.2	-1.1	0.4
Age at First Birth	0.3	0.4	0.7	0.8	-0.3
Neuroticism (2016)	0.3	0.4	0.8	0.3	-0.9
Schizophrenia (2014)	0.3	0.7	1.1	-0.5	1.1
Blood Red Count	0.3	2.5	4.9	-2.2	-0.1
Hypothyroidism (self reported)	0.3	0.8	1.2	-0.5	-1.1
Vitamin and mineral supplements	0.3	0.5	0.5	-0.6	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	0.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.2	-0.8
Sitting height	0.3	2.1	2.6	1.6	1.2
High blood pressure (mother)	0.3	0.4	0.8	0.2	0.9
Alcohol usually taken with meals	0.3	0.5	0.6	0.8	0.6
Nervous feelings	0.3	0.5	1.0	-0.2	1.0
Forced vital capacity (FVC)	0.3	1.1	2.2	1.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.3	0.1	-1.1
Body fat percentage	0.3	1.1	2.1	-1.4	-0.2
Medication: Blood pressure	0.3	0.6	1.2	0.1	-1.1
Medication: Ibuprofen	0.3	0.4	0.5	-0.7	-0.6
Number of full sisters	0.3	0.3	0.5	0.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.7	0.4
Miserableness	0.3	0.5	0.8	0.4	-0.9
Medication: Bendroflumethiazide	0.3	0.4	0.5	-0.7	0.6
Arm fat-free mass (left)	0.3	1.4	2.8	1.7	0.3
Myopia	0.3	0.4	0.8	0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	0.9	-0.8	0.9
Pain experienced in last month	0.3	0.5	1.1	-1.0	-0.1
Arm predicted mass (left)	0.3	1.5	3.0	1.7	0.3
Neuroticism (Nagel 2018)	0.2	0.5	0.6	0.7	-0.8
Fasting Glucose	0.2	0.2	0.4	0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.5	0.7	-0.2
Trunk fat percentage	0.2	0.7	1.3	-1.1	0.2
Relative age voice broke	0.2	0.3	0.7	0.8	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.1	0.9
Stomach or abdominal pain in last month	0.2	0.3	0.4	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.1	0.1	1.1
Medication: Ramipril	0.2	0.3	0.6	0.8	0.2
Impedance of arm (right)	0.2	1.0	1.1	-1.0	1.1
Falls in the last year	0.2	0.3	0.6	-0.8	0.2
Number of live births	0.2	0.3	0.4	-0.4	0.6
Pulse rate	0.2	0.3	0.5	-0.3	-0.7
Asthma	0.2	0.4	0.7	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.8	0.9	0.7
Tense / ‘highly strung’	0.2	0.3	0.6	-0.7	-0.2
Pulse wave reflection index	0.2	0.2	0.4	-0.2	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.5	0.6
Gout (self-reported)	0.2	0.3	0.4	0.3	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.3	0.6
Shortness of breath walking on level ground	0.2	0.3	0.4	0.4	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	0.9	0.0
Medication: Allopurinol	0.2	0.3	0.4	-0.4	-0.6
Comparative height size at age 10	0.2	1.1	2.1	-0.2	1.4
Knee pain experienced in last month	0.2	0.4	0.6	-0.8	0.4
Ever had bowel cancer screening	0.2	0.3	0.5	0.1	0.7
Qualifications: nursing, teaching	0.2	0.4	0.5	0.7	-0.5
Asthma (self-reported)	0.2	0.3	0.5	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.5	-0.7	0.4
Guilty feelings	0.2	0.2	0.5	0.0	0.7
Medication: Blood pressure	0.2	0.5	0.9	1.0	0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.3	-0.4	-0.6
Medication: Lisinopril	0.2	0.3	0.5	0.7	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.3	-0.5	-0.6
Diastolic blood pressure, automated reading	0.2	0.6	0.6	0.8	-0.7
Impedance of whole body	0.2	0.8	1.3	-1.2	-0.5
Worry (Nagel 2018)	0.1	0.2	0.4	-0.1	0.6
Lupus	0.1	0.2	0.3	-0.6	-0.0
BMI	0.1	0.6	0.7	-0.7	0.8
Waist Hip Ratio (WHR)	0.1	0.4	0.6	-0.3	0.8
Cardiovascular Disease	0.1	0.4	0.6	0.8	-0.4
Neuroticism	0.1	0.3	0.6	-0.8	0.2
Hair Pigment	0.1	2.2	3.8	2.0	-0.8
Number of treatments/medications taken	0.1	0.1	0.2	-0.4	-0.1
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.5	0.0
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.7	0.1
Diabetes (mother)	0.1	0.2	0.2	0.4	-0.4
Pack years adult smoking proportion	0.1	0.1	0.2	0.4	-0.3
Maternal smoking around birth	0.1	0.1	0.2	0.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	0.4
Had other major operations	0.1	0.1	0.3	0.1	0.5
Allergy	0.1	0.1	0.2	0.0	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.3	0.5
Neuroticism score	0.1	0.3	0.5	-0.7	0.0
Weight	0.1	0.6	0.7	0.6	0.9
Arm fat percentage (right)	0.1	0.5	0.9	-0.9	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	0.3	0.6
Impedance of arm (left)	0.1	0.6	0.6	-0.8	0.8
Number of full brothers	0.1	0.2	0.3	0.2	0.6
Worry too long after embarrassment	0.1	0.2	0.4	0.3	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	-0.5	-0.3
Neck or shoulder pain in last month	0.1	0.2	0.3	0.6	-0.2
Leg fat mass (right)	0.1	0.4	0.8	-0.9	-0.0
Leg pain on walking	0.1	0.1	0.2	0.3	0.4
Hypertension (Self-reported)	0.1	0.1	0.3	-0.5	-0.1
Illnesses of father: Heart disease	0.1	0.1	0.2	0.1	0.4
Arm fat percentage (left)	0.1	0.2	0.5	-0.7	0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.1	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.2	0.4	0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.1	-0.3
Number of operations (self-reported)	0.1	0.1	0.2	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	-0.3
Supplements: Calcium	0.1	0.1	0.2	-0.3	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.1	0.4
Pack years of smoking	0.1	0.1	0.3	0.5	0.1
Leg fat mass (left)	0.1	0.4	0.8	-0.9	-0.1
Ovarian Cancer	0.0	0.1	0.1	-0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	-0.3
HDL Cholesterol	0.0	0.1	0.1	0.3	0.1
Respiratory disease	0.0	0.1	0.1	-0.4	0.2
Tanning	0.0	0.0	0.1	-0.1	-0.3
Relative age of first facial hair	0.0	0.1	0.1	-0.3	0.2
Average weekly fortified wine intake	0.0	0.0	0.0	-0.0	-0.1
High blood pressure	0.0	0.0	0.1	-0.2	-0.2
Body mass index (BMI)	0.0	0.1	0.3	-0.5	-0.1
Trunk fat mass	0.0	0.2	0.2	-0.3	0.5
Waist circumference	0.0	0.1	0.1	0.2	0.3
Qualifications: None of the above	0.0	0.1	0.2	-0.4	0.0
Mouth/teeth dental problems	0.0	0.0	0.0	0.1	0.0
Hip circumference	0.0	0.1	0.2	0.4	0.3
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.1	-0.2
Depression (self-reported)	0.0	0.0	0.0	0.1	-0.1
Arm fat mass (right)	0.0	0.0	0.0	-0.1	0.2
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.1	0.0
Medication: Omeprazole	0.0	0.1	0.1	0.3	0.2
Whole body fat mass	0.0	0.1	0.1	-0.3	-0.1
Had major operations	0.0	0.0	0.1	0.2	0.0
Arm fat mass (left)	0.0	0.0	0.1	0.1	0.2
Commuting to job workplace: Public transport	0.0	0.1	0.1	-0.0	0.3

Hub : Genes

SPRED2

Models

Trait associations