Hub : Genes

SPRY2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.1130 0.0418 7.9e-04 0.019 NA 0.036 NA 0.026 1.2e-02 NA 9.4e-04 NA 4.0e-03
2 GTEx Pancreas 0.2250 0.0860 8.2e-03 0.011 NA 0.001 NA 0.008 1.1e-01 NA 2.9e-01 NA 1.4e-01
3 YFS Blood 0.0551 0.0157 3.2e-08 0.050 0.031 0.046 0.048 0.048 5.5e-16 1.3e-10 9.7e-15 1.8e-15 2.4e-15

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.4 2.2 5.1 -1.1 -0.7 -2.3
Bipolar Disorder or Schizophrenia 2.0 5.0 11.0 -1.8 -0.9 -3.3
Depressed Affect (Nagel 2018) 1.1 2.3 3.8 1.1 1.4 1.9
Depression (Nagel 2018) 1.5 2.2 4.2 1.4 0.7 2.1
Intelligence (Savage-Jansen 2018) 0.6 1.8 3.6 1.2 0.7 1.9
Neuroticism (Nagel 2018) 0.8 1.9 3.6 0.8 1.2 1.9
Schizophrenia (2018) 1.3 2.8 5.9 -1.4 -0.6 -2.4
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 -0.1 -0.7 -0.5
Worry (Nagel 2018) 0.0 0.1 0.2 0.2 0.5 -0.2
Alzheimer’s Disease (in mother) 0.8 0.9 2.4 -0.6 0.3 -1.5
Alzheimer’s Disease (in father) 1.0 1.0 2.9 1.7 0.5 -0.1
Alzheimer’s Disease (including proxy) 0.7 1.0 1.6 1.2 -0.1 -1.3
Crohns Disease (2017) 0.5 1.0 1.6 1.1 -0.6 -1.2
Irritable Bowel Disease (IBD) 0.7 1.6 2.8 -0.5 -1.3 -1.7
Ulcerative Colitis (UC) 1.6 2.9 3.7 -1.9 -1.9 -1.3
Major Depression (MDD) 0.3 0.4 0.9 0.9 0.3 0.4
Reaction Time 0.4 0.8 1.6 0.3 -1.3 0.7
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.7 0.8 0.8 1.6
Breast Cancer 0.1 0.3 0.8 -0.3 -0.9 0.3
Ovarian Cancer 0.2 0.2 0.7 0.1 -0.8 0.1
Prostate Cancer 2.1 3.0 6.4 -1.6 -2.5 -0.0
Age at First Birth 0.4 0.6 1.7 -0.1 -1.3 -0.3
Bipolar Disorder (2011) 0.9 0.9 1.3 -1.1 0.3 -1.1
Body Mass Index (BMI) (2010) 2.7 3.6 8.7 1.0 -2.9 -1.1
Coronary Artery Disease (CAD) 1.8 2.2 5.7 -0.9 0.0 -2.4
Crohns Disease (2012) 0.9 1.5 3.0 1.7 -0.2 -1.1
Mean Putamen Volume 3.2 3.7 6.0 -2.4 -1.8 -1.3
Fasting Glucose 0.3 0.4 1.2 1.1 0.2 0.1
HbA1C 0.2 0.2 0.5 0.3 0.7 -0.3
HDL Cholesterol 1.0 1.7 3.7 1.9 -0.1 1.1
LDL Cholesterol 1.0 1.6 3.0 -1.7 -0.8 -1.2
Lupus 0.9 1.3 2.6 -1.1 0.3 -1.6
Neuroticism (2016) 0.5 0.8 1.1 0.9 1.1 0.6
Primary Biliary Cirrhosis 1.2 1.8 4.4 -0.3 -0.9 -2.1
Rheumatoid Arthritis 0.2 0.2 0.5 0.7 0.4 -0.1
Schizophrenia (2014) 1.1 2.5 7.2 -0.4 -0.3 -2.7
Triglycerides 0.8 1.2 2.8 -0.9 -0.1 -1.7
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.8 0.4 0.7 1.7
Ulcerative Colitis 1.8 2.5 4.4 -0.2 -2.1 -1.8
Blood Eosinophil Count 0.5 3.6 7.9 -1.6 -2.8 -0.7
Blood Platelet Count 0.5 5.4 14.0 1.4 -3.7 0.7
Blood Red Count 0.1 1.3 2.5 -0.3 1.6 -1.1
Blood White Count 0.0 0.2 0.4 -0.7 -0.4 0.4
Heel T-Score 1.3 10.3 18.1 4.2 1.6 3.2
BMI 0.6 3.7 7.2 2.7 -1.7 1.0
Height 1.3 25.2 31.9 5.7 -4.3 -5.0
Waist Hip Ratio (WHR) 0.0 0.0 0.0 0.1 -0.0 -0.2
Systolic Blood Pressure 0.6 3.2 6.8 1.7 0.4 -2.6
Smoking Status 1.1 2.6 6.2 -2.5 -1.2 0.1
Allergy or Eczema 1.9 5.0 13.3 3.6 -1.0 0.9
Cardiovascular Disease 0.3 1.0 2.1 0.8 -0.4 -1.4
Hypothyroidism (self reported) 1.3 3.1 5.1 -0.7 -2.3 -1.9
Respiratory disease 0.8 1.8 3.2 1.8 -1.3 0.7
Type 2 Diabetes (T2D) (2018) 3.9 7.3 10.0 3.2 2.2 2.7
Lung FEV1/FVC ratio 0.5 2.7 4.8 1.5 1.0 2.2
Lung FVC 0.8 4.1 10.8 0.7 3.3 -1.1
Neuroticism 0.3 0.7 1.8 0.5 -0.2 1.3
Chronotype (morning person) 0.1 0.1 0.2 -0.4 -0.1 0.5
Hair Pigment 0.0 1.2 3.0 -0.8 -0.3 -1.7
Tanning 0.1 1.2 1.6 1.3 1.3 0.6
Hand grip strength (left) 0.9 2.5 5.6 -1.2 0.6 -2.4
Number of treatments/medications taken 1.9 3.4 6.7 1.6 -2.6 -1.0
Average weekly spirits intake 2.3 2.8 6.2 2.5 -0.1 1.5
Sensitivity / hurt feelings 1.0 1.7 3.6 1.9 -1.1 0.7
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.8 1.3 0.5 0.7
Hearing difficulty/problems: Yes 0.9 1.3 3.7 1.9 -0.3 -0.4
Relative age of first facial hair 0.2 0.5 1.1 1.1 -0.4 0.5
Other serious medical condition/disability diagnosed by doctor 2.7 3.6 10.6 3.2 -0.1 0.3
Ever used hormone-replacement therapy (HRT) 0.0 0.1 0.1 0.4 -0.0 -0.1
Ever had hysterectomy (womb removed) 0.3 0.3 0.5 -0.2 -0.6 -0.7
Systolic blood pressure, automated reading 0.9 2.6 4.4 1.8 -0.3 -2.1
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 3.6 1.9 -0.8 0.3
Angina 1.5 1.9 5.0 0.9 -0.2 2.2
Medication for hormone replacement therapy 0.3 0.3 0.7 -0.8 -0.5 0.1
Vitamin and mineral supplements 0.7 0.9 2.3 -0.6 0.3 1.5
Supplements: Zinc 1.0 1.1 2.4 -0.8 -1.6 -0.4
Medication: Co-codamol 1.2 1.4 3.5 -0.8 -1.9 -0.5
Medication: Metformin 7.8 11.0 16.5 3.9 1.0 4.1
Diabetes (father) 3.0 3.7 8.1 1.2 2.8 1.3
Diabetes (mother) 3.6 4.6 8.8 0.5 3.0 2.2
Severe depression (siblings) 1.0 1.1 2.4 0.3 -1.6 0.9
Pack years adult smoking proportion 1.5 2.2 5.2 2.3 -0.8 -0.9
Impedance of leg (right) 0.0 0.1 0.3 0.0 -0.2 -0.5
Leg fat-free mass (left) 1.4 7.3 16.5 4.1 -2.1 -1.0
Trunk fat percentage 1.3 5.4 11.0 3.3 -2.2 0.5
Hand grip strength (right) 0.9 2.3 5.1 -1.3 0.5 -2.3
Townsend deprivation index at recruitment 0.1 0.1 0.3 0.2 0.1 -0.5
Current tobacco smoking 0.3 0.5 1.0 0.3 -1.0 -0.6
Average weekly fortified wine intake 0.3 0.3 0.6 0.8 -0.1 0.6
Maternal smoking around birth 1.0 1.4 3.8 0.5 -2.0 -0.5
Fed-up feelings 1.0 1.8 2.2 1.4 1.5 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.3 1.5 0.8 1.0
Relative age voice broke 0.1 0.2 0.4 -0.3 -0.4 -0.6
Taking other prescription medications 0.6 1.0 1.7 1.0 -1.3 0.4
Age when periods started (menarche) 0.0 0.1 0.2 0.2 -0.4 -0.3
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 6.0 0.3 2.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.1 7.0 2.7 -0.7 1.3
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.8 0.4 1.3 -0.6
Qualifications: CSEs or equivalent 0.1 0.1 0.1 -0.2 0.1 0.4
Serious illness, injury or assault to yourself 0.5 0.6 1.7 0.4 -1.3 0.2
High blood pressure 1.2 3.4 8.7 1.2 -0.4 -3.0
Hayfever, allergic rhinitis or eczema 1.8 4.0 10.9 3.3 -0.5 0.9
Multivitamins +/- minerals 0.4 0.6 0.8 0.8 -0.5 -0.9
Stomach or abdominal pain in last month 0.5 0.7 1.8 -0.1 -1.4 -0.3
Supplements: Glucosamine 0.9 1.2 3.0 1.7 -0.5 0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.4 -0.6 0.6 -0.2
Medication: Atenolol 2.6 3.3 5.1 2.3 -2.1 -0.4
Medication: Levothyroxine sodium 1.2 2.1 2.6 -1.6 -1.4 -1.4
Sitting height 1.7 11.8 19.0 4.4 -3.5 -2.1
Chronic bronchitis/emphysema (father) 0.4 0.5 0.8 0.9 -0.7 0.3
High blood pressure (mother) 0.4 0.6 1.3 0.7 1.2 0.2
Body mass index (BMI) 0.9 3.7 9.9 3.1 -0.8 0.8
Impedance of leg (left) 0.1 0.3 0.6 -0.1 -0.8 -0.3
Leg predicted mass (left) 1.3 7.0 15.9 4.0 -2.0 -1.0
Trunk fat mass 1.7 7.4 15.7 4.0 -2.5 0.2
Waist circumference 1.4 5.0 13.2 3.6 -1.4 0.2
Number of incorrect matches in round 0.5 0.8 1.6 -0.6 -0.5 -1.3
Past tobacco smoking 1.0 1.9 4.9 2.2 0.4 -0.7
Alcohol usually taken with meals 0.4 0.6 1.3 0.6 -0.3 -1.2
Nervous feelings 0.3 0.5 1.3 1.2 -0.5 0.0
Frequency of tenseness / restlessness in last 2 weeks 4.0 6.2 8.2 2.9 2.1 2.4
Hearing difficulty/problems with background noise 1.9 3.1 6.7 1.4 -2.6 0.7
Hair/balding pattern: Pattern 2 1.9 2.4 6.2 2.5 1.0 0.2
Had menopause 1.2 1.5 2.7 1.6 -0.9 1.0
Had other major operations 1.1 1.4 2.5 -0.0 -1.3 -1.6
Forced vital capacity (FVC) 0.8 2.9 5.0 1.8 0.6 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.4 5.5 2.4 -0.5 1.2
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 5.5 1.0 -2.3 0.0
Qualifications: None of the above 0.8 1.7 2.9 -1.7 0.3 -1.4
Financial difficulties in last 2 years 1.3 1.8 3.1 1.8 0.3 1.4
Mouth/teeth dental problems 0.6 1.0 2.5 -1.6 0.6 0.2
Heart attack 2.2 2.8 6.2 2.5 0.6 1.3
Allergy 2.0 4.5 13.1 -3.6 0.4 -0.4
Pain all over the body in last month 0.3 0.3 0.6 -0.0 0.6 0.8
Diabetes (self-reported) 3.4 5.2 9.4 3.1 0.5 2.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.7 0.4 0.2 1.9
Medication: Ramipril 0.9 1.2 1.9 -0.3 -1.3 -1.4
Medication: Simvastatin 1.2 1.7 4.7 2.2 -0.5 0.6
Fluid intelligence score 0.1 0.1 0.2 0.5 0.4 0.2
Illnesses of siblings 0.7 1.0 2.3 -1.5 0.3 0.9
Neuroticism score 1.1 2.4 5.2 2.3 0.4 1.3
Weight 1.8 8.9 20.2 4.5 -2.5 -0.6
Impedance of arm (right) 0.4 2.0 3.3 -1.4 -1.8 -1.0
Arm fat percentage (right) 1.1 4.2 8.4 2.9 -1.9 0.7
Trunk fat-free mass 1.1 6.5 15.1 3.9 -1.9 -0.9
Hip circumference 1.2 5.3 11.7 3.4 -2.0 -0.0
Time employed in main current job 1.0 1.2 1.9 0.4 -1.4 -1.2
Alcohol intake versus 10 years previously 0.4 0.6 0.9 0.5 1.0 0.9
Father’s age at death 0.0 0.0 0.1 0.0 0.2 -0.3
Worrier / anxious feelings 0.1 0.2 0.4 0.2 -0.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 4.0 2.0 -1.6 -0.5
Falls in the last year 2.6 3.6 6.8 2.6 1.8 0.8
Hair/balding pattern: Pattern 3 1.6 2.4 6.2 -0.9 -2.5 -0.4
Number of live births 0.3 0.5 1.0 -1.0 0.6 -0.3
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 5.6 2.4 0.9 -2.1
Pulse rate 0.9 1.5 2.8 -1.1 1.7 -0.7
Happiness 0.9 1.1 1.9 0.0 1.4 -1.1
Noisy workplace 1.4 1.7 3.2 -0.2 -1.4 -1.8
Qualifications: A levels/AS levels or equivalent 0.5 1.2 2.2 0.6 1.1 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.6 1.0 1.3 0.3
Mouth/teeth dental problems: Dentures 0.4 0.7 1.9 1.4 0.4 0.1
Asthma 1.7 3.3 9.1 3.0 -0.5 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.2 0.2 -0.9 -1.5
Medication: Cholesterol lowering 1.1 1.7 2.5 1.6 -0.1 1.6
Depression (self-reported) 0.2 0.2 0.6 -0.2 -0.0 -0.8
Medication: Lansoprazole 0.0 0.1 0.1 0.1 -0.4 -0.0
Prospective memory result 0.3 0.4 0.9 -0.9 -0.5 0.1
Lung cancer (father) 0.3 0.4 0.9 -0.6 -0.9 0.2
Illnesses of mother 0.0 0.1 0.1 -0.3 0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 4.4 2.1 0.6 -2.1
Pulse wave Arterial Stiffness index 0.7 0.8 1.3 -0.9 0.5 1.1
Impedance of arm (left) 0.3 1.4 2.5 -1.6 -1.2 -0.6
Arm fat mass (right) 1.6 6.4 14.7 3.8 -2.1 0.2
Trunk predicted mass 1.1 6.4 14.9 3.9 -1.8 -1.0
Standing height 1.3 12.6 15.7 3.6 -4.0 -3.0
Length of working week for main job 1.4 1.6 3.5 -0.9 0.6 -1.9
Exposure to tobacco smoke at home 0.8 0.9 2.6 0.0 0.3 1.6
Breastfed as a baby 0.1 0.1 0.2 0.1 -0.5 0.3
Tense / ‘highly strung’ 0.2 0.3 0.5 0.4 0.6 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.1 6.7 2.6 -0.1 1.6
Hair/balding pattern: Pattern 4 1.1 2.7 6.0 -2.5 0.1 1.4
Birth weight of first child 0.3 0.6 1.1 1.1 -0.7 -0.2
Peak expiratory flow (PEF) 1.0 2.2 4.9 0.9 1.0 -2.2
Pulse wave reflection index 0.5 0.6 1.0 -0.2 0.8 1.0
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.7 -0.3 -0.8 -0.1
Loud music exposure frequency 0.7 0.8 2.1 -0.1 -0.4 -1.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.3 -1.1 0.7 0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.3 1.1 0.7 0.4
Blood clot in the leg (DVT) 0.0 0.1 0.1 -0.3 -0.1 -0.2
Medication: Paracetamol 0.9 1.6 3.1 1.1 -0.6 -1.8
Headache pain in last month 0.6 1.1 2.9 1.7 0.5 0.3
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 5.9 -2.4 0.8 0.3
Glaucoma (self-reported) 0.5 0.6 0.9 -0.9 -0.6 -0.8
Gout (self-reported) 0.2 0.3 0.5 -0.5 0.2 -0.7
Hypothyroidism/myxoedema (self-reported) 1.7 3.3 3.8 -1.6 -2.0 -1.8
Medication: Amlodipine 0.4 0.6 1.0 -0.8 1.0 0.2
Medication: Ventolin 100micrograms inhaler 1.2 1.6 2.9 1.7 -1.2 -0.7
Birth weight 0.3 0.7 1.8 -0.4 -1.3 0.0
Chronic bronchitis/emphysema (mother) 3.1 3.7 7.5 0.6 -2.7 -1.8
High blood pressure (siblings) 0.9 1.4 2.8 0.8 -0.9 -1.7
Forced vital capacity (FVC), Best measure 0.7 2.4 3.5 1.8 0.7 -1.9
Body fat percentage 1.3 5.3 11.6 3.4 -2.0 0.6
Leg fat percentage (right) 1.1 3.9 10.1 3.2 -1.2 0.2
Arm fat-free mass (right) 1.5 7.7 21.1 4.6 -1.3 -0.5
Exposure to tobacco smoke outside home 1.1 1.5 2.2 -1.1 1.5 1.1
Comparative body size at age 10 0.1 0.2 0.4 0.6 -0.1 -0.4
Number of full brothers 0.5 0.6 1.2 0.8 -1.1 0.0
Worry too long after embarrassment 1.5 2.4 4.8 1.5 -0.6 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 2.1 1.4 -1.0 1.1
Wheeze or whistling in the chest in last year 1.3 2.3 6.5 2.5 -0.6 0.1
Number of children fathered 1.1 1.2 2.9 -1.7 -0.6 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.7 0.7 0.8 -0.5
Age at first live birth 0.3 0.6 1.4 0.4 1.2 0.5
Pulse wave peak to peak time 1.0 1.2 1.9 1.0 -0.7 -1.4
Health satisfaction 0.9 1.2 1.8 1.3 -1.3 0.4
Shortness of breath walking on level ground 1.6 1.9 3.1 1.6 -1.8 0.4
Qualifications: College or University degree 0.5 1.7 3.2 1.8 -1.1 -0.8
Eye problems/disorders: None of the above 0.1 0.1 0.4 -0.6 0.1 -0.1
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.5 0.7 0.1
Emphysema/chronic bronchitis 0.4 0.5 1.3 0.3 -0.2 1.1
Medication for pain relief, constipation, heartburn 1.7 2.9 4.9 -2.2 1.7 0.8
Neck or shoulder pain in last month 1.5 2.2 2.5 1.3 -1.6 -1.6
Medication: Blood pressure 1.0 1.7 4.0 2.0 -0.9 -0.6
Angina (self-reported) 1.4 1.9 4.7 0.9 -0.3 2.2
Migraine (self-reported) 0.2 0.3 0.6 -0.8 -0.2 0.4
Medication: Ibuprofen 0.5 0.6 1.6 -0.2 -0.4 -1.3
Medication: Allopurinol 0.7 0.9 2.3 0.4 1.5 -0.6
Medication: Omeprazole 1.8 2.1 4.0 0.9 -2.0 -1.2
Medication: Seretide 50 evohaler 0.9 1.0 2.8 1.7 -0.5 -0.3
Mean time to correctly identify matches 0.7 1.3 2.4 0.2 -1.5 1.2
Heart disease (mother) 0.9 1.1 2.9 -0.3 -1.7 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 4.2 0.1 -2.0 -1.3
Whole body fat mass 1.8 7.6 17.2 4.1 -2.4 0.1
Leg fat mass (right) 2.1 8.2 20.1 4.5 -2.1 -0.2
Arm predicted mass (right) 1.5 7.4 19.9 4.5 -1.4 -0.6
Pulse rate, automated reading 0.4 1.2 1.9 -1.1 1.4 -0.7
Alcohol intake frequency. 0.3 0.8 1.6 0.6 -1.2 0.6
Comparative height size at age 10 0.6 3.3 4.6 2.1 -1.8 -1.4
Number of full sisters 1.0 1.2 2.6 -1.0 -1.6 -0.3
Suffer from ‘nerves’ 0.5 0.8 1.7 1.3 0.1 0.9
Overall health rating 2.0 4.3 7.7 2.8 -1.7 1.5
Chest pain or discomfort 3.7 5.4 11.0 3.3 -2.1 -0.8
Had major operations 1.4 1.7 3.8 1.0 0.5 1.9
Age at last live birth 0.1 0.1 0.3 0.5 0.3 -0.1
Family relationship satisfaction 0.3 0.4 0.6 0.3 0.8 -0.7
Leg pain on walking 0.6 0.7 1.1 1.0 0.4 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.1 0.3 0.5
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.3 0.2 -1.1 -1.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.8 -0.9 0.2 0.4
Medication: Aspirin 1.5 2.0 3.1 1.7 0.6 1.6
Supplements: Vitamin C 0.4 0.5 1.1 -0.5 0.4 -1.1
Knee pain experienced in last month 1.9 2.9 8.5 2.9 0.2 -0.3
Hypertension (Self-reported) 1.1 2.9 6.8 1.2 -0.7 -2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.2 0.9 0.5 -1.5
Illnesses of father: Heart disease 1.6 2.2 4.6 -2.1 -1.1 -0.8
Illnesses of siblings: Diabetes 3.7 4.6 7.0 2.7 1.2 2.3
Smoking status: Previous 1.5 2.3 6.6 -2.6 0.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.0 1.2 -1.4 -0.9
Whole body fat-free mass 1.3 7.4 17.5 4.2 -2.0 -0.8
Leg fat-free mass (right) 1.2 6.5 13.6 3.7 -2.3 -0.8
Arm fat percentage (left) 0.9 3.7 8.2 2.9 -1.5 0.7
Average weekly red wine intake 0.7 1.0 2.5 0.8 -1.6 -0.2
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.8 -0.0 -1.9 -1.1
Mood swings 0.8 1.4 3.3 1.8 0.9 0.1
Loneliness, isolation 0.4 0.6 1.1 1.0 0.4 0.7
Long-standing illness, disability or infirmity 3.7 5.6 14.3 3.8 -1.5 0.6
Ever had bowel cancer screening 2.8 3.2 8.3 -0.2 -2.9 -1.1
Diabetes diagnosed by doctor 4.2 7.0 11.1 3.3 0.7 3.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 1.9 -1.4 1.3 -0.6
Friendships satisfaction 1.3 1.7 4.8 2.2 0.4 -0.2
Qualifications: nursing, teaching 0.7 1.0 3.1 1.8 -0.2 0.1
Commuting to job workplace: Walk 2.1 2.2 5.1 2.3 1.1 0.6
Eye problems/disorders: Cataract 0.3 0.4 1.1 -0.1 0.2 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.2 -0.6 0.1
Medication for cholesterol 0.6 0.9 2.0 0.3 0.9 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 4.8 2.2 -0.7 1.0
Back pain experienced in last month 1.0 1.5 2.8 1.7 -0.8 -1.0
Mineral and other dietary supplements 0.3 0.4 0.7 -0.9 0.2 0.6
Breast cancer (self-reported) 1.7 2.0 3.9 1.4 0.5 2.0
Asthma (self-reported) 1.9 3.7 10.3 3.2 -0.6 -0.6
Osteoporosis (self-reported) 0.4 0.5 1.4 -1.2 -0.1 -0.5
Osteoarthritis (self-reported) 0.8 1.1 2.0 1.4 -0.6 -0.9
Medication: Aspirin 1.1 1.4 2.1 1.3 0.5 1.4
Medication: Gliclazide 6.9 7.8 15.7 4.0 0.6 2.7
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 0.0 0.5 0.4
Smoking status: Current 0.2 0.4 1.0 0.3 -1.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 3.9 1.2 2.0 0.6
Whole body water mass 1.3 7.3 17.6 4.2 -2.0 -0.8
Leg predicted mass (right) 1.3 6.7 14.3 3.8 -2.3 -0.8
Arm fat mass (left) 1.5 6.0 14.1 3.8 -2.0 -0.0
Number of self-reported non-cancer illnesses 2.9 5.0 6.3 2.1 -2.5 -2.1
Average weekly champagne plus white wine intake 0.4 0.6 0.9 -0.8 -0.4 -1.0
Miserableness 1.0 1.7 4.3 2.1 0.4 0.8
Guilty feelings 0.0 0.1 0.2 -0.4 -0.1 0.0
Wears glasses or contact lenses 1.3 1.5 1.9 -1.1 -1.4 -1.2
Ever taken oral contraceptive pill 0.7 0.8 1.5 -1.2 -0.5 -0.7
Hearing aid user 0.1 0.1 0.3 -0.5 -0.3 -0.2
Mother’s age at death 0.2 0.2 0.7 -0.2 -0.8 -0.2
Financial situation satisfaction 0.4 0.5 1.1 -0.5 -0.4 -1.0
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.6 0.8 -0.5 -1.3
Commuting to job workplace: Public transport 0.5 0.6 1.1 -0.4 0.7 1.1
Eye problems/disorders: Glaucoma 1.0 1.1 2.5 -1.6 -0.7 -0.6
Medication: Blood pressure 0.8 1.6 2.4 1.0 -1.1 -1.5
Pain type(s) experienced in last month: Hip pain 2.3 2.9 5.1 2.3 -1.8 0.4
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 0.6 0.4 -0.2
High cholesterol (Self-reported) 0.2 0.4 0.6 0.8 0.6 -0.5
Medication: Bendroflumethiazide 0.5 0.8 1.6 1.0 0.1 -1.2
Medication: Paracetamol 0.5 0.7 1.5 0.7 0.4 -1.2
Medication: Lisinopril 1.3 1.7 4.7 2.2 -0.7 0.3
Medication: Atorvastatin 0.7 0.8 1.1 1.0 0.6 1.1
Illnesses of father: High blood pressure 0.8 1.0 1.8 1.3 0.2 -1.0
Alcohol drinker status: Never 0.2 0.3 0.5 0.1 -0.6 0.7
Ever smoked 0.5 0.9 1.8 -1.4 -0.8 0.4
Basal metabolic rate 1.5 8.4 19.9 4.5 -2.1 -0.8
Leg fat percentage (left) 1.1 3.9 8.9 3.0 -1.7 0.4
Arm fat-free mass (left) 1.5 7.7 19.5 4.4 -1.8 -0.6
Number of operations (self-reported) 0.6 0.9 2.0 0.2 -1.4 -0.8
Average weekly beer plus cider intake 0.1 0.2 0.6 -0.7 0.1 -0.3
Irritability 1.6 2.6 5.7 1.2 0.9 2.4
Risk taking 1.2 1.7 2.6 1.6 1.6 -0.0
Ever had prostate specific antigen (PSA) test 1.4 1.7 2.1 -1.3 -1.1 -1.5
Fractured/broken bones in last 5 years 1.4 1.8 5.1 -0.4 -0.2 2.2
Age started oral contraceptive pill 1.3 1.6 4.7 2.2 0.3 0.3
Diastolic blood pressure, automated reading 1.4 4.5 10.9 3.3 0.4 -1.5
Ever depressed for a whole week 0.3 0.4 0.6 0.7 -0.8 0.4
Unable to work because of sickness or disability 1.5 1.9 4.7 2.2 -0.7 0.7
Commuting to job workplace: Cycle 1.1 1.3 2.7 1.7 -0.6 0.8
Myopia 0.9 1.3 3.8 1.9 0.0 0.2
Vascular/heart problems diagnosed by doctor 0.7 1.9 4.0 -1.1 0.7 2.0
Cholesterol lowering medication 0.3 0.5 1.1 1.0 -0.4 -0.5
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.8 0.8 -1.7 -0.8
Pain experienced in last month 1.5 2.6 5.7 -2.4 0.5 1.3
Supplements: Calcium 0.5 0.5 1.5 1.2 -0.2 -0.1
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 0.6 -0.6 0.2
Heart attack/myocardial infarction (self-reported) 2.1 2.7 6.2 2.5 0.6 1.3
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.1 -0.3 0.1 -0.3
Heart disease (siblings) 1.2 1.5 3.0 -0.8 -1.7 -0.9
Alcohol drinker status: Previous 0.2 0.2 0.6 0.8 -0.1 -0.1
Pack years of smoking 1.6 2.3 5.0 2.2 -1.0 -1.0
Impedance of whole body 0.2 0.8 1.4 -1.2 -0.8 -0.6
Leg fat mass (left) 2.2 8.4 19.4 4.4 -2.4 0.1
Arm predicted mass (left) 1.7 8.6 21.8 4.7 -1.8 -0.9