Hub : Genes

SPTLC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.2331	0.0731	1.3e-04	0.036	NA	0.068	NA	0.062	4.9e-03	NA	1.8e-04	NA	3.4e-04
2	GTEx	Nerve Tibial	0.3276	0.0591	7.3e-13	0.287	NA	0.379	NA	0.363	1.5e-20	NA	3.6e-28	NA	8.7e-27
3	GTEx	Skin Sun Exposed Lower leg	0.1440	0.0440	2.8e-05	0.060	NA	0.065	NA	0.038	1.1e-05	NA	4.8e-06	NA	3.9e-04
4	METSIM	Adipose	0.0549	0.0226	1.8e-03	0.002	0.009	0.008	0.012	0.006	1.5e-01	1.2e-02	1.9e-02	6.0e-03	3.3e-02
5	NTR	Blood	0.0575	0.0180	6.1e-08	0.054	0.028	0.067	0.061	0.067	6.9e-17	2.1e-09	9.0e-21	6.8e-19	1.4e-20
6	YFS	Blood	0.0408	0.0130	1.9e-05	0.008	0.014	0.022	0.017	0.020	7.5e-04	1.5e-05	8.3e-08	2.5e-06	2.7e-07
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0362	0.0164	4.4e-03	0.003	0.010	-0.002	NA	0.001	1.4e-01	2.2e-02	6.9e-01	NA	2.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.5	-1.0	1.2	0.1	0.5	0.6	-0.3	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	1.9	-0.7	1.4	-0.0	0.3	0.4	-0.1	-0.5
Depressed Affect (Nagel 2018)	0.8	1.8	7.7	2.8	0.4	-0.0	1.1	1.1	1.1	-1.0
Depression (Nagel 2018)	0.4	0.6	2.6	-0.3	0.9	-0.6	0.3	-0.2	0.3	-1.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.1	-0.1	-0.6	1.4	-1.7	-0.6	-1.8	0.2
Neuroticism (Nagel 2018)	0.9	2.2	6.0	2.5	0.3	0.7	1.9	1.8	1.4	-0.2
Schizophrenia (2018)	0.1	0.1	0.6	-0.0	0.8	-0.1	0.0	-0.1	-0.2	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	0.7	-0.9	-0.3	0.0	-0.5	-0.6	-0.4	0.0
Worry (Nagel 2018)	0.6	1.3	2.1	1.2	0.8	1.0	1.2	1.5	1.3	-0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	0.8	-0.9	0.2	0.5	0.8	1.3	0.5
Alzheimer’s Disease (in father)	2.5	2.7	5.1	-2.3	0.7	-1.6	-1.2	-2.1	-1.2	-1.9
Alzheimer’s Disease (including proxy)	0.8	1.2	2.3	-1.2	0.0	-1.0	-1.2	-1.3	-0.0	-1.5
Crohns Disease (2017)	2.5	5.4	20.5	-0.4	-0.2	-1.0	-1.4	-4.5	-2.9	-2.5
Irritable Bowel Disease (IBD)	2.2	5.1	15.5	-1.0	0.8	-1.9	-0.9	-3.9	-2.2	-3.0
Ulcerative Colitis (UC)	0.8	1.5	3.6	-0.8	1.4	-1.4	0.0	-1.6	-0.5	-1.9
Major Depression (MDD)	1.9	2.4	5.7	1.9	0.2	2.0	0.3	2.4	1.7	0.1
Reaction Time	0.7	1.3	5.4	-0.1	0.2	-0.3	2.3	0.6	1.8	0.4
Verbal and Numeric Reasoning (VNR)	1.0	2.3	9.0	-1.9	0.5	-0.3	-3.0	-0.2	-1.6	-0.9
Breast Cancer	0.5	1.2	5.0	-0.2	-0.7	0.7	0.5	1.0	-0.9	2.2
Ovarian Cancer	2.2	2.9	8.5	-1.2	-2.0	-1.0	-0.3	-2.9	-2.3	-0.5
Prostate Cancer	0.7	1.0	2.6	-1.0	-0.9	-1.3	-0.2	-1.6	0.4	0.9
Age at First Birth	0.5	0.8	2.7	-1.3	-0.2	0.1	-0.3	-1.0	-1.6	0.3
Bipolar Disorder (2011)	3.1	3.0	7.7	2.4	0.1	1.8	2.8	0.9	1.9	0.4
Body Mass Index (BMI) (2010)	1.5	2.0	5.8	1.0	-2.4	1.8	0.6	-0.6	0.7	1.7
Coronary Artery Disease (CAD)	0.6	0.7	1.3	0.9	-0.6	-0.1	0.9	-1.1	-0.5	-1.0
Crohns Disease (2012)	1.0	1.7	6.4	-0.0	-0.1	0.0	-0.6	-2.5	-1.3	-1.8
Mean Putamen Volume	0.5	0.6	1.9	1.4	-0.7	1.0	0.7	-0.4	-0.2	-0.3
Fasting Glucose	0.5	0.6	3.2	0.2	-1.8	-0.2	-0.1	-0.7	0.1	0.7
HbA1C	0.4	0.4	1.1	0.9	-0.3	-0.1	1.0	-0.8	-0.6	-0.4
HDL Cholesterol	0.9	1.6	2.8	-1.3	-0.8	-1.2	-1.2	-1.7	-1.6	-0.4
LDL Cholesterol	0.4	0.7	1.3	0.2	-0.7	1.2	-0.7	0.9	0.8	0.8
Lupus	0.9	1.3	2.7	-0.7	1.5	-1.2	-1.1	-1.1	-0.5	-1.6
Neuroticism (2016)	1.2	1.8	5.1	1.9	0.9	-0.6	0.9	1.2	2.3	-0.0
Primary Biliary Cirrhosis	0.3	0.4	1.9	1.4	0.4	0.1	-0.5	-0.1	0.6	0.1
Rheumatoid Arthritis	0.6	0.8	2.6	1.0	-1.1	0.1	0.7	0.7	0.3	1.6
Schizophrenia (2014)	0.2	0.4	1.9	-0.1	1.4	0.2	-0.6	0.2	0.1	-0.6
Triglycerides	1.3	2.2	5.9	2.4	0.1	-0.1	0.1	2.3	1.6	1.3
Type 2 Diabetes (T2D) (2012)	1.6	1.9	5.1	0.5	-2.0	2.3	-0.8	-1.3	-1.2	0.4
Ulcerative Colitis	0.3	0.4	1.0	-0.3	0.3	-1.0	-0.4	-0.9	0.4	-0.6
Blood Eosinophil Count	1.8	14.1	25.8	3.1	-0.1	4.6	4.3	5.1	3.6	3.1
Blood Platelet Count	0.1	1.6	3.1	1.7	-0.5	-1.5	-0.4	-1.8	0.6	1.4
Blood Red Count	0.1	1.2	3.4	-0.5	-1.3	1.8	0.8	1.3	-0.3	0.7
Blood White Count	0.1	0.8	3.6	-0.0	-0.1	-0.2	1.9	0.6	-1.0	0.9
Heel T-Score	0.1	1.1	3.3	1.8	-0.4	0.9	1.2	-1.1	-0.7	0.3
BMI	0.7	4.0	7.7	2.5	-2.8	2.3	2.6	0.3	0.0	1.2
Height	1.0	18.9	31.6	-5.6	0.6	-4.8	-5.3	-5.1	-4.2	-2.3
Waist Hip Ratio (WHR)	0.1	0.3	1.5	-0.2	-0.2	0.3	-1.2	-0.6	-0.2	-0.6
Systolic Blood Pressure	0.3	1.6	3.9	2.0	-0.5	1.2	1.1	-1.3	-0.5	1.4
Smoking Status	0.3	0.8	2.3	-0.4	0.4	-0.5	-0.2	1.1	1.5	1.2
Allergy or Eczema	0.3	0.8	3.6	-0.0	-1.9	-0.2	1.0	-0.6	-0.7	0.3
Cardiovascular Disease	0.2	0.7	2.3	1.5	0.5	0.4	0.9	0.1	1.0	0.0
Hypothyroidism (self reported)	0.7	1.6	3.0	1.2	-0.6	1.0	1.7	0.9	1.7	1.2
Respiratory disease	1.1	2.5	7.2	2.2	-1.2	1.6	2.7	0.5	0.9	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.0	0.7	-0.5	0.9	-1.0	0.1	-0.5	0.8
Lung FEV1/FVC ratio	0.1	0.7	2.9	0.3	0.4	-0.4	-1.7	-0.7	0.2	-1.1
Lung FVC	0.9	4.4	10.6	-2.8	0.7	-2.0	-3.3	-2.4	-1.3	-0.5
Neuroticism	1.3	3.0	6.2	2.5	-0.1	1.3	2.2	1.7	2.3	0.3
Chronotype (morning person)	1.4	3.2	9.7	-3.1	0.0	-3.1	-1.0	-1.5	-0.2	0.0
Hair Pigment	0.0	1.1	1.9	0.9	-1.1	1.4	-0.9	-0.3	-1.2	1.2
Tanning	0.4	4.3	9.0	0.8	1.2	1.1	3.0	3.0	2.4	1.7
Hand grip strength (left)	3.7	9.7	18.8	-2.0	2.1	-1.9	-2.5	-4.3	-4.0	-3.7
Number of treatments/medications taken	0.7	1.2	5.2	0.2	-0.8	1.4	2.3	-0.5	0.3	-0.1
Average weekly spirits intake	0.9	1.2	2.6	-1.6	-0.8	-1.0	-0.2	-1.4	-1.3	-0.7
Sensitivity / hurt feelings	0.5	0.8	2.1	0.8	0.4	-1.0	-0.1	1.3	1.4	-0.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	4.4	-0.5	0.6	-0.8	-0.5	-0.2	0.0	-2.1
Hearing difficulty/problems: Yes	0.3	0.5	2.6	-0.1	-1.6	0.3	0.5	-0.0	-0.1	0.8
Relative age of first facial hair	0.7	1.4	4.6	1.0	1.2	0.3	-1.3	2.2	0.4	1.0
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.1	-1.0	-0.6	-1.1	-0.9	-2.3	-1.5	-1.5
Ever used hormone-replacement therapy (HRT)	1.8	2.3	6.6	2.6	-0.9	1.6	1.5	0.5	2.0	0.0
Ever had hysterectomy (womb removed)	2.5	2.8	6.9	0.0	1.7	-1.3	-1.5	-2.2	-1.3	-2.6
Systolic blood pressure, automated reading	0.3	0.9	2.6	1.6	0.1	-0.1	0.6	-1.6	-1.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.3	-0.4	0.8	-0.9	-1.1	-0.4	1.1	-0.5
Angina	0.5	0.6	1.2	1.1	-0.7	0.4	-1.1	-0.4	0.9	-0.3
Medication for hormone replacement therapy	0.3	0.3	1.5	1.2	-0.3	-0.2	-0.4	-0.5	-0.1	-0.5
Vitamin and mineral supplements	0.1	0.2	0.6	-0.8	-0.0	-0.0	-0.4	0.2	0.4	0.3
Supplements: Zinc	1.2	1.3	2.4	1.5	-0.8	-0.0	0.9	-1.1	-1.6	-1.2
Medication: Co-codamol	1.5	1.7	4.8	0.8	-0.3	2.2	2.0	0.1	0.9	1.3
Medication: Metformin	1.1	1.6	6.2	0.2	-1.0	1.3	0.4	1.3	0.8	2.5
Diabetes (father)	1.4	1.7	3.9	0.9	-0.1	1.8	0.4	1.7	2.0	0.9
Diabetes (mother)	2.7	3.4	8.2	-1.3	0.4	-0.7	-0.9	-2.9	-2.7	-2.2
Severe depression (siblings)	1.1	1.2	2.8	-1.7	-0.6	-1.3	1.2	-1.1	-0.9	-0.6
Pack years adult smoking proportion	0.2	0.4	2.0	-0.4	-1.4	-0.0	0.1	0.5	-0.4	0.4
Impedance of leg (right)	0.3	1.4	3.1	-1.4	1.5	-1.4	0.2	-0.0	0.9	-1.8
Leg fat-free mass (left)	0.2	1.0	2.7	-0.2	-1.3	0.0	-0.7	-1.2	-1.6	0.5
Trunk fat percentage	0.7	2.9	7.5	2.3	-2.0	1.8	2.7	0.1	0.3	0.3
Hand grip strength (right)	1.8	4.9	12.4	-1.1	0.8	-1.5	-2.5	-3.5	-2.7	-2.1
Townsend deprivation index at recruitment	1.6	2.3	6.3	0.6	0.2	1.5	0.9	2.3	2.5	1.3
Current tobacco smoking	0.3	0.6	3.2	0.6	0.5	0.1	-1.8	0.4	0.0	-0.2
Average weekly fortified wine intake	0.6	0.7	1.2	-0.4	0.4	-1.0	0.7	-1.1	-0.9	1.1
Maternal smoking around birth	0.8	1.2	5.4	1.4	0.2	-0.2	2.3	0.6	0.3	0.9
Fed-up feelings	0.4	0.8	3.0	1.7	-0.3	-0.6	0.3	1.2	0.4	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	3.8	-0.8	1.3	-0.5	-0.1	0.7	0.2	-1.9
Relative age voice broke	0.0	0.1	0.2	0.1	0.4	0.1	-0.3	0.0	0.2	-0.2
Taking other prescription medications	1.6	2.5	6.6	1.5	-1.2	1.9	2.6	1.4	1.2	0.3
Age when periods started (menarche)	0.3	0.8	2.7	-0.0	1.6	-1.1	-0.0	0.8	-0.1	1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	4.0	0.7	0.7	-0.8	-0.6	-0.9	-0.7	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.3	1.1	-0.1	1.1	-0.3	-0.7	-0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	0.9	1.0	0.5	-0.9	-0.4	0.1	-1.4
Qualifications: CSEs or equivalent	1.0	1.3	5.3	-0.3	-0.6	0.2	2.3	-1.2	-0.9	-1.0
Serious illness, injury or assault to yourself	0.9	1.1	3.1	0.2	-0.4	-1.2	0.3	-1.8	-1.7	-0.3
High blood pressure	0.0	0.1	0.5	-0.1	-0.0	-0.0	0.0	-0.7	-0.3	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.0	-0.7	-0.7	0.5	0.6	-0.5	0.5
Multivitamins +/- minerals	0.3	0.3	0.5	0.6	-0.6	-0.7	0.3	-0.5	-0.6	-0.6
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.5	0.1	0.2	-0.4	0.8	0.5	0.5
Supplements: Glucosamine	0.3	0.4	1.2	0.1	-1.1	1.1	0.7	-0.3	0.0	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	-1.0	-0.7	-0.6	0.5	-0.0	0.6	0.1
Medication: Atenolol	0.4	0.5	1.1	-0.0	0.6	-1.1	-0.8	-0.8	0.3	-0.7
Medication: Levothyroxine sodium	0.3	0.4	1.5	0.3	-1.2	-1.0	-0.4	0.3	0.3	0.5
Sitting height	1.0	7.4	12.3	-3.5	1.8	-3.3	-3.3	-2.6	-2.2	-1.7
Chronic bronchitis/emphysema (father)	1.7	2.0	5.1	1.8	-0.9	2.3	1.4	1.6	0.3	0.2
High blood pressure (mother)	0.3	0.4	0.8	-0.6	-0.7	0.3	0.8	-0.9	-0.7	0.1
Body mass index (BMI)	0.8	3.2	6.5	2.6	-2.2	2.4	2.2	0.4	0.1	0.6
Impedance of leg (left)	0.2	1.0	1.8	-1.0	1.2	-1.3	0.4	-0.2	0.9	-1.3
Leg predicted mass (left)	0.2	0.9	2.5	-0.3	-1.2	0.0	-0.7	-1.1	-1.6	0.5
Trunk fat mass	0.4	1.7	3.8	1.7	-2.0	1.4	1.8	-0.3	-0.4	0.2
Waist circumference	0.3	1.3	2.8	1.7	-1.5	1.6	0.9	-0.4	-0.5	-0.0
Number of incorrect matches in round	0.5	0.9	2.7	-0.6	1.0	-1.6	0.4	0.8	1.1	0.2
Past tobacco smoking	0.9	1.6	4.5	2.1	-1.1	1.5	-0.6	-0.5	-1.6	-0.5
Alcohol usually taken with meals	0.2	0.3	0.5	-0.7	-0.6	-0.2	-0.5	0.0	0.7	0.3
Nervous feelings	0.3	0.5	1.5	-0.1	1.2	0.4	-1.0	-0.5	0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.2	2.1	1.4	-0.3	0.7	2.3	1.8	-0.8
Hearing difficulty/problems with background noise	0.3	0.4	1.3	-0.6	0.5	-0.9	-0.6	-0.2	-0.3	-1.1
Hair/balding pattern: Pattern 2	1.8	2.3	3.5	1.8	1.9	1.3	0.9	1.9	1.6	-0.7
Had menopause	0.7	0.9	2.1	1.3	-0.8	1.4	0.2	-0.1	-0.0	-1.4
Had other major operations	0.6	0.8	2.6	1.0	-1.2	1.6	-0.2	0.3	-0.3	0.2
Forced vital capacity (FVC)	2.0	7.7	15.3	-3.4	1.3	-3.1	-3.9	-3.4	-2.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.9	1.7	-0.5	1.1	0.1	-0.3	-0.3	0.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.9	1.7	0.6	-0.8	-0.2	0.5	0.9	-0.0
Qualifications: None of the above	3.0	6.4	12.4	3.0	0.6	1.6	3.1	2.8	3.5	1.7
Financial difficulties in last 2 years	0.4	0.6	1.3	-0.7	-1.2	-0.8	-0.2	-0.5	-0.7	0.8
Mouth/teeth dental problems	0.3	0.4	1.4	-0.6	0.3	1.2	-0.4	-0.7	-0.9	0.1
Heart attack	0.3	0.4	2.0	0.0	-0.1	-0.1	-1.4	-0.8	-0.6	0.3
Allergy	0.5	1.1	3.7	-1.5	0.2	-0.2	-1.9	-1.1	-0.5	-0.6
Pain all over the body in last month	0.8	0.8	3.8	0.2	-2.0	0.6	0.1	0.1	0.9	0.7
Diabetes (self-reported)	0.3	0.4	0.7	0.8	-0.7	0.8	-0.6	-0.1	-0.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.6	-0.5	-0.7	0.4	0.2	-0.6	-0.7
Medication: Ramipril	1.0	1.3	5.3	0.1	-1.5	2.3	0.2	0.4	0.2	1.1
Medication: Simvastatin	0.2	0.3	0.7	-0.2	0.9	0.4	-0.4	-0.6	0.1	-0.6
Fluid intelligence score	1.9	4.0	12.0	-2.4	0.9	-0.6	-3.5	-1.5	-2.4	-0.9
Illnesses of siblings	2.2	3.1	4.5	-2.1	1.6	-2.0	-1.4	-1.5	-1.3	-2.0
Neuroticism score	0.5	1.0	2.1	1.4	0.0	-0.2	1.3	1.2	1.2	-0.3
Weight	0.1	0.7	1.8	0.7	-1.3	0.6	0.2	-0.9	-1.1	-0.1
Impedance of arm (right)	0.0	0.2	0.4	0.1	0.6	-0.7	0.4	-0.2	0.4	-0.5
Arm fat percentage (right)	1.3	5.2	11.9	3.5	-2.8	3.0	2.5	0.3	0.2	1.0
Trunk fat-free mass	0.5	3.0	5.6	-1.8	-0.0	-1.5	-2.1	-2.1	-2.4	-0.6
Hip circumference	0.4	1.6	3.7	1.5	-1.9	1.3	1.5	-0.5	-0.1	0.7
Time employed in main current job	1.1	1.3	3.3	1.1	-0.7	0.3	0.9	1.8	1.0	1.4
Alcohol intake versus 10 years previously	1.7	2.5	3.8	1.1	-1.5	1.8	1.0	2.0	1.9	1.5
Father’s age at death	0.3	0.4	1.5	-0.8	-0.2	0.2	0.3	0.7	1.2	0.2
Worrier / anxious feelings	0.2	0.5	1.1	0.2	0.3	-0.0	0.8	1.1	1.0	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.0	1.0	0.0	1.0	-1.7	-0.6	-0.1	-0.5
Falls in the last year	1.2	1.7	4.3	2.1	-1.3	1.1	1.6	0.9	0.7	0.6
Hair/balding pattern: Pattern 3	2.7	4.0	8.0	-2.6	1.0	-1.7	-1.4	-2.8	-2.3	-1.6
Number of live births	0.7	1.1	3.0	-0.7	0.7	-1.2	-1.4	-1.7	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	2.8	9.5	21.5	-3.5	1.2	-3.1	-4.6	-3.9	-2.4	-0.9
Pulse rate	1.1	1.8	5.2	0.1	0.9	-1.4	2.3	1.1	1.6	-0.9
Happiness	0.8	1.0	2.1	1.0	1.5	0.8	-0.8	0.8	0.5	-1.3
Noisy workplace	1.1	1.4	4.4	0.5	1.2	-0.8	1.6	0.3	0.5	-2.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.6	-1.6	0.4	0.1	-0.8	-0.9	-1.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	5.9	0.9	0.3	2.4	0.1	-0.5	0.3	-1.5
Mouth/teeth dental problems: Dentures	0.2	0.3	1.1	-0.4	-0.5	-1.1	0.2	-0.2	0.5	0.1
Asthma	0.7	1.3	3.6	1.9	-0.8	1.4	1.0	0.9	0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	-0.6	-1.0	0.6	0.6	-0.0	0.2	0.6
Medication: Cholesterol lowering	0.2	0.4	1.3	-0.1	0.4	0.1	1.0	-1.1	-0.5	0.1
Depression (self-reported)	1.4	1.7	5.1	-0.4	0.7	0.2	0.8	2.2	2.3	-0.5
Medication: Lansoprazole	0.4	0.5	1.7	0.1	-0.6	0.7	0.6	-1.3	-0.4	-0.7
Prospective memory result	0.9	1.2	3.8	0.7	1.3	0.1	2.0	0.7	1.2	-0.3
Lung cancer (father)	0.2	0.3	0.8	0.9	0.0	-0.7	-0.3	-0.2	0.5	-0.5
Illnesses of mother	1.4	1.7	4.3	-0.8	1.2	-2.1	-1.5	0.9	1.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	12.1	-3.2	2.0	-2.6	-3.5	-2.7	-1.4	-0.7
Pulse wave Arterial Stiffness index	0.6	0.7	2.3	-0.3	0.3	-0.5	-1.0	-0.4	-1.5	0.9
Impedance of arm (left)	0.1	0.3	0.7	-0.8	0.5	-0.8	0.2	0.1	0.5	-0.3
Arm fat mass (right)	0.7	3.1	6.4	2.5	-2.3	2.3	2.0	-0.1	-0.2	0.6
Trunk predicted mass	0.5	3.0	5.8	-1.9	-0.1	-1.5	-2.1	-2.2	-2.4	-0.7
Standing height	1.0	10.1	16.5	-4.0	1.6	-3.8	-4.1	-3.0	-3.0	-1.7
Length of working week for main job	1.0	1.1	3.1	-0.9	0.7	-0.3	-1.6	0.8	-0.1	-1.8
Exposure to tobacco smoke at home	3.2	3.6	8.0	1.3	-2.7	2.8	2.6	0.7	0.4	0.9
Breastfed as a baby	1.8	2.2	4.2	-1.6	-1.5	0.3	-1.4	-1.9	-2.1	-1.1
Tense / ‘highly strung’	1.6	2.7	6.3	1.8	0.3	-0.5	2.1	2.0	2.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.1	0.4	1.4	0.1	-0.2	1.4	0.7	-0.4
Hair/balding pattern: Pattern 4	0.2	0.5	2.0	-0.3	-0.0	0.4	0.2	-1.0	-0.3	-1.4
Birth weight of first child	0.2	0.3	1.0	1.0	0.3	0.4	0.5	0.5	0.3	0.3
Peak expiratory flow (PEF)	2.0	4.6	9.9	-2.7	1.0	-1.3	-3.1	-3.1	-1.5	-0.5
Pulse wave reflection index	1.6	2.0	4.6	-1.8	-0.7	-0.3	-1.9	-0.5	-2.1	1.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	0.0	1.1	-0.1	-0.2	0.6	0.6	-0.5
Loud music exposure frequency	0.5	0.6	1.3	-0.1	-0.7	0.3	1.0	1.0	0.0	1.1
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.6	-0.8	1.2	0.3	-1.4	-2.2	-1.2	-1.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.1	0.8	-1.5	-0.5	0.6	-0.2	0.2	-0.6
Blood clot in the leg (DVT)	0.5	0.6	1.5	0.7	1.1	0.1	0.7	1.2	0.2	-0.9
Medication: Paracetamol	0.3	0.5	1.3	0.0	0.4	1.1	0.9	0.2	0.9	-0.7
Headache pain in last month	0.5	0.8	2.5	-0.6	1.3	0.1	-1.0	-0.4	-0.0	-1.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.5	-0.4	0.5	-0.5	-1.9	0.6	-0.3	-1.6
Glaucoma (self-reported)	1.3	1.5	2.7	1.4	-1.6	1.3	1.1	-0.6	0.0	1.6
Gout (self-reported)	0.3	0.4	1.2	-1.1	-0.6	-0.5	0.4	0.0	0.2	-0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.2	0.9	-0.5	-0.3	1.0	1.1	2.0	0.4
Medication: Amlodipine	0.5	0.7	1.7	-0.5	-0.0	0.7	-1.0	-1.3	0.1	-1.1
Medication: Ventolin 100micrograms inhaler	1.4	1.9	3.8	1.0	-0.3	0.8	1.9	1.9	1.9	0.6
Birth weight	0.2	0.5	0.9	0.6	0.9	-0.2	0.7	0.9	0.7	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.5	0.3	0.2	-0.5	-0.9	-1.2	-1.1	-1.1
High blood pressure (siblings)	0.3	0.4	1.5	0.6	-0.7	0.7	0.5	-0.0	0.0	1.2
Forced vital capacity (FVC), Best measure	1.5	5.3	10.3	-3.0	1.8	-2.4	-3.2	-2.5	-1.3	-0.5
Body fat percentage	0.9	3.4	7.3	2.7	-2.1	2.2	2.7	0.2	0.3	0.2
Leg fat percentage (right)	0.6	2.3	5.2	2.3	-1.6	2.0	2.0	0.3	0.4	-0.3
Arm fat-free mass (right)	0.2	1.1	3.4	-1.1	-0.3	-0.3	-1.0	-1.3	-1.8	-0.7
Exposure to tobacco smoke outside home	3.5	4.7	15.5	2.7	-0.9	1.4	3.9	1.8	1.9	0.2
Comparative body size at age 10	2.6	7.3	13.6	2.0	-3.7	3.4	3.3	0.4	0.2	3.4
Number of full brothers	0.5	0.6	2.3	0.5	0.3	1.0	0.4	0.1	1.5	0.8
Worry too long after embarrassment	0.2	0.3	1.0	0.8	-0.3	0.4	0.6	0.1	-0.1	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.8	1.1	0.3	0.1	1.7	1.3	1.1	-0.7
Wheeze or whistling in the chest in last year	2.0	3.6	12.9	1.7	-1.8	3.6	1.1	1.4	1.6	0.9
Number of children fathered	0.2	0.2	0.5	-0.4	0.4	-0.1	0.3	-0.0	0.7	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	4.1	0.7	0.1	2.0	-0.1	0.4	0.8	-0.3
Age at first live birth	3.0	5.4	11.3	-2.8	-0.2	-2.8	-1.9	-2.6	-3.4	-0.5
Pulse wave peak to peak time	0.4	0.4	1.5	-0.1	-0.0	0.0	0.6	0.1	1.2	-1.0
Health satisfaction	0.3	0.4	1.9	-0.5	-0.2	0.5	-0.2	0.1	0.1	-1.4
Shortness of breath walking on level ground	0.2	0.3	1.1	1.0	-0.1	0.4	-0.4	-0.2	-0.3	0.5
Qualifications: College or University degree	0.7	2.3	6.1	-2.3	0.3	-0.3	-2.5	-1.1	-1.7	-0.3
Eye problems/disorders: None of the above	0.9	1.0	3.6	-0.6	1.9	-1.2	-1.2	0.0	0.5	-0.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.3	0.0	1.4	-0.4	-1.0	0.6	0.5	-2.1
Emphysema/chronic bronchitis	1.1	1.3	2.5	1.2	-1.1	1.6	1.6	0.6	0.4	0.9
Medication for pain relief, constipation, heartburn	0.8	1.3	4.0	0.3	0.4	-1.3	-1.1	-1.1	-2.0	-1.1
Neck or shoulder pain in last month	0.1	0.2	0.5	0.2	0.5	0.4	0.0	-0.0	0.6	-0.7
Medication: Blood pressure	0.7	1.2	3.0	0.4	-1.2	0.5	1.6	-1.0	0.2	1.7
Angina (self-reported)	0.5	0.7	1.6	1.3	-1.1	0.4	-1.0	-0.7	0.7	-0.1
Migraine (self-reported)	2.2	2.7	6.9	0.9	0.7	1.2	2.6	2.0	2.2	0.6
Medication: Ibuprofen	0.8	1.0	2.5	-0.7	-1.2	0.9	1.6	0.4	0.9	0.9
Medication: Allopurinol	1.1	1.5	4.8	0.1	-0.4	0.7	2.2	1.4	1.6	0.6
Medication: Omeprazole	0.9	1.1	2.7	0.8	-0.3	1.6	-0.0	0.3	1.2	1.6
Medication: Seretide 50 evohaler	0.4	0.5	1.3	0.4	-0.3	1.1	1.1	0.2	0.6	0.3
Mean time to correctly identify matches	0.9	1.7	5.8	-1.2	0.5	-1.6	2.4	0.0	0.9	-1.1
Heart disease (mother)	1.2	1.5	5.7	0.8	-0.5	0.5	-0.1	-2.4	-1.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	0.9	1.2	-0.1	0.8	-0.4	-0.6	-1.3
Whole body fat mass	0.4	1.8	3.9	2.0	-1.7	1.7	1.7	-0.1	-0.2	0.0
Leg fat mass (right)	0.5	1.9	4.1	2.0	-1.8	1.7	1.8	0.0	-0.0	0.1
Arm predicted mass (right)	0.2	0.9	2.5	-1.1	-0.4	-0.3	-1.2	-1.0	-1.6	-0.2
Pulse rate, automated reading	1.0	3.2	15.7	-0.3	1.1	-4.0	-0.4	-0.7	-0.5	-2.2
Alcohol intake frequency.	0.3	0.7	2.4	0.2	-0.5	-0.2	-0.4	-1.0	-0.8	-1.5
Comparative height size at age 10	1.0	5.6	11.9	-2.5	-0.2	-2.9	-3.1	-3.5	-1.9	-0.4
Number of full sisters	0.2	0.2	0.6	0.5	-0.6	0.8	-0.3	-0.3	-0.5	0.0
Suffer from ‘nerves’	0.4	0.6	2.9	0.4	0.2	0.3	-0.9	-0.3	-0.0	-1.7
Overall health rating	0.3	0.7	2.2	0.8	-0.7	0.7	-0.2	0.5	1.0	-1.5
Chest pain or discomfort	0.6	0.9	3.1	1.5	-0.4	1.8	0.1	0.3	0.4	0.5
Had major operations	1.6	1.9	6.9	-0.1	-2.6	0.7	2.2	-0.7	-0.6	0.0
Age at last live birth	2.2	3.2	9.4	-1.8	-0.4	-1.3	-1.5	-2.4	-3.1	0.0
Family relationship satisfaction	0.7	0.9	1.4	-1.2	1.1	0.6	0.2	1.0	1.0	-1.1
Leg pain on walking	2.9	3.6	9.9	2.5	-0.4	3.2	2.7	0.6	0.8	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	-0.5	-0.6	-0.2	0.6	0.6	-0.1	-1.0
Commuting to job workplace: Car/motor vehicle	1.4	1.6	6.0	1.9	-2.4	0.1	0.3	-0.2	0.5	-1.0
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.9	-1.2	-0.1	-1.7	-0.9	0.7	0.3	0.9
Medication: Aspirin	0.2	0.2	0.8	0.7	-0.2	0.4	0.4	-0.1	0.3	0.9
Supplements: Vitamin C	0.6	0.7	2.7	0.9	0.5	0.8	0.1	-0.3	-0.4	-1.6
Knee pain experienced in last month	2.0	3.1	5.8	2.4	-1.9	2.3	1.6	1.4	1.5	0.4
Hypertension (Self-reported)	0.1	0.2	0.5	0.2	-0.5	0.6	0.4	-0.7	-0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-0.9	-0.3	1.0	0.1	-0.9	-0.2	-0.2
Illnesses of father: Heart disease	0.7	1.0	3.3	0.8	0.9	0.2	-0.2	-1.8	-0.4	-1.3
Illnesses of siblings: Diabetes	1.8	2.2	4.9	1.5	-1.9	2.2	0.6	1.4	0.4	1.4
Smoking status: Previous	0.6	0.9	2.2	-1.5	0.5	-1.0	0.9	-0.0	1.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.4	-0.2	0.3	-0.0	-1.1	-0.8	-1.2	-0.5
Whole body fat-free mass	0.3	1.7	4.2	-1.2	-0.5	-0.9	-1.6	-1.7	-2.0	-0.1
Leg fat-free mass (right)	0.3	1.3	3.6	-0.3	-1.4	0.0	-1.1	-1.5	-1.9	0.7
Arm fat percentage (left)	1.2	4.9	9.3	3.0	-2.8	3.1	2.3	0.6	0.4	1.2
Average weekly red wine intake	0.4	0.6	1.7	0.7	0.3	1.3	-0.1	1.0	0.7	0.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.8	0.9	-0.6	1.9	-0.0	0.8	1.0	0.6
Mood swings	0.6	1.0	4.1	2.0	-0.2	0.2	1.1	0.8	1.0	-0.3
Loneliness, isolation	1.6	2.2	11.9	-0.3	1.5	0.2	0.1	0.8	-0.1	-3.5
Long-standing illness, disability or infirmity	0.6	0.9	2.6	0.1	-0.2	0.9	0.8	-1.3	-0.9	-1.6
Ever had bowel cancer screening	0.7	0.8	3.7	0.9	0.9	-0.2	0.4	-0.2	-0.3	-1.9
Diabetes diagnosed by doctor	0.3	0.5	1.1	0.7	-0.9	0.9	-0.2	0.3	0.3	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.9	-1.4	-0.6	-0.1	-0.7	-1.3	-0.4	-0.5
Friendships satisfaction	0.7	0.9	2.9	-0.7	1.7	-0.4	-1.1	-0.4	-0.4	-1.1
Qualifications: nursing, teaching	1.7	2.6	9.1	-1.2	-0.9	-0.7	-2.0	-1.5	-3.0	-0.0
Commuting to job workplace: Walk	1.4	1.6	4.7	-2.2	1.5	0.7	-0.1	-0.9	-1.5	-0.7
Eye problems/disorders: Cataract	1.1	1.3	3.8	0.0	-1.9	1.6	0.5	-0.4	-1.4	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.6	1.6	1.1	-0.4	1.3	0.8	-0.2	-0.5
Medication for cholesterol	0.5	0.8	1.5	-0.6	-0.1	-1.2	1.0	0.9	0.8	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	7.5	1.8	-2.7	0.9	1.4	2.0	1.8	1.8
Back pain experienced in last month	1.2	1.7	6.4	0.1	-1.3	2.5	-0.2	-0.8	0.5	-1.7
Mineral and other dietary supplements	0.4	0.5	2.8	-0.2	0.0	-0.7	-1.7	0.4	-0.4	-0.5
Breast cancer (self-reported)	1.1	1.4	3.8	1.4	0.4	1.9	1.7	0.5	0.6	-0.3
Asthma (self-reported)	0.5	1.0	2.9	1.7	-0.9	1.0	1.0	0.8	0.8	-0.5
Osteoporosis (self-reported)	0.3	0.3	1.3	-0.1	-1.1	0.4	0.7	0.2	-0.3	-0.4
Osteoarthritis (self-reported)	0.3	0.3	1.7	-1.3	-0.6	-0.5	0.1	-0.0	-0.1	0.0
Medication: Aspirin	0.2	0.2	0.6	0.8	0.5	0.3	0.5	-0.0	0.3	0.5
Medication: Gliclazide	0.4	0.4	1.4	0.1	-0.7	1.2	-0.8	-0.0	-0.4	0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	2.2	-1.5	-0.6	-1.4	-0.7	0.2	0.4	1.0
Smoking status: Current	0.3	0.5	1.9	0.5	0.3	0.4	-1.4	0.8	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	9.1	-0.4	0.1	-0.5	-0.8	-3.0	-1.7	1.4
Whole body water mass	0.3	1.5	4.0	-1.1	-0.6	-0.5	-1.5	-1.5	-2.0	-0.1
Leg predicted mass (right)	0.2	1.2	3.1	-0.2	-1.5	0.1	-1.0	-1.3	-1.8	0.8
Arm fat mass (left)	0.7	2.8	6.1	2.3	-2.2	2.5	1.8	0.0	-0.1	0.6
Number of self-reported non-cancer illnesses	0.7	1.2	3.9	0.6	-0.1	-0.5	2.0	-0.5	0.9	-1.7
Average weekly champagne plus white wine intake	1.9	2.7	5.1	-2.3	1.2	-1.7	-1.4	-1.4	-1.7	-1.6
Miserableness	0.6	1.0	5.2	0.7	0.4	-2.3	-0.5	-0.0	-0.3	-0.7
Guilty feelings	0.6	0.8	3.3	0.7	1.8	0.1	1.2	0.6	0.3	-0.4
Wears glasses or contact lenses	1.0	1.1	2.2	-0.4	1.5	-1.4	-0.4	-1.4	-1.1	-0.5
Ever taken oral contraceptive pill	2.4	2.6	8.1	-2.8	-0.0	-1.8	-1.3	-1.7	-0.7	-1.3
Hearing aid user	0.7	0.8	1.5	-1.0	-0.9	0.7	-0.2	-0.8	-1.2	-1.0
Mother’s age at death	0.4	0.5	1.6	-0.9	0.1	-0.3	0.6	-0.6	-1.3	0.4
Financial situation satisfaction	0.1	0.1	0.5	-0.1	-0.3	-0.2	-0.5	0.0	0.2	0.7
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.8	0.9	-0.1	0.1	0.4	0.2	-0.1	0.4
Commuting to job workplace: Public transport	1.1	1.3	4.6	-1.0	2.1	-0.6	-0.6	-1.0	-1.0	-0.8
Eye problems/disorders: Glaucoma	1.5	1.7	3.3	1.7	-1.8	1.0	1.2	-0.8	0.2	1.7
Medication: Blood pressure	0.5	1.0	3.1	0.0	-0.1	1.8	-0.9	-1.0	-1.1	-0.9
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.5	-0.0	-1.3	1.6	0.3	-0.9	0.0	-0.2
Supplements: Fish oil (including cod liver oil)	1.3	1.8	5.1	1.0	1.9	0.3	2.2	0.0	1.2	1.0
High cholesterol (Self-reported)	0.3	0.6	2.1	0.5	1.5	0.2	0.6	-1.0	0.1	-0.5
Medication: Bendroflumethiazide	0.9	1.4	4.0	0.4	-2.0	1.0	1.0	-0.9	-1.4	0.9
Medication: Paracetamol	0.3	0.5	1.4	-0.1	0.2	0.8	1.2	0.2	1.1	-0.6
Medication: Lisinopril	0.4	0.5	2.2	0.7	-0.6	0.1	0.1	-1.5	-0.5	0.3
Medication: Atorvastatin	0.5	0.6	1.5	-1.2	0.6	-0.4	-1.1	-0.7	0.5	0.4
Illnesses of father: High blood pressure	0.9	1.1	3.9	2.0	0.6	1.2	0.5	-0.5	-0.5	-1.2
Alcohol drinker status: Never	3.5	4.2	7.0	-1.4	0.0	-2.3	-2.2	-2.2	-2.6	-2.4
Ever smoked	1.0	1.7	6.0	-2.4	0.9	-2.0	-0.9	-0.1	0.6	-0.2
Basal metabolic rate	0.2	1.2	3.6	-0.8	-0.8	-0.4	-1.2	-1.6	-1.9	-0.0
Leg fat percentage (left)	0.8	3.1	7.2	2.7	-2.1	2.3	2.1	0.2	0.3	0.2
Arm fat-free mass (left)	0.2	1.2	3.9	-0.6	-0.2	-0.2	-1.0	-1.5	-2.0	-0.7
Number of operations (self-reported)	0.7	1.1	3.3	1.1	-1.8	1.6	0.6	-0.4	-0.2	0.4
Average weekly beer plus cider intake	2.0	2.8	8.9	1.2	1.6	0.9	1.1	3.0	2.1	-0.7
Irritability	2.0	3.4	7.2	1.0	-2.2	0.7	2.2	2.7	1.7	1.7
Risk taking	1.1	1.7	4.2	0.3	-2.0	0.1	0.4	1.9	0.2	2.0
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	-0.1	0.1	-1.1	0.4	-0.9	-0.1	0.5
Fractured/broken bones in last 5 years	0.3	0.4	2.0	-0.4	0.2	0.5	1.4	0.4	-0.3	-0.6
Age started oral contraceptive pill	0.6	0.7	2.0	1.2	0.3	1.4	0.3	0.7	0.4	1.0
Diastolic blood pressure, automated reading	0.3	0.9	3.0	0.4	0.0	-0.8	-0.4	-1.4	-1.7	-0.3
Ever depressed for a whole week	0.5	0.6	2.3	0.5	1.5	-0.0	0.7	-0.2	0.7	-0.9
Unable to work because of sickness or disability	0.3	0.4	1.4	0.6	-0.6	0.1	-0.1	0.8	1.2	-0.1
Commuting to job workplace: Cycle	1.0	1.2	4.4	-0.7	0.3	-0.5	-1.2	-1.3	-2.1	-0.3
Myopia	0.6	0.8	2.4	0.3	-0.5	-1.6	0.9	0.2	-0.1	1.5
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.3	0.2	-0.1	0.2	0.6	0.0	0.3
Cholesterol lowering medication	0.4	0.6	1.8	-0.3	0.1	1.4	-1.0	-0.5	-0.7	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.4	0.3	-0.9	1.3	-0.1	0.1	1.3	1.9
Pain experienced in last month	0.8	1.3	4.5	-0.5	1.6	-2.1	0.6	-0.7	-1.0	-0.2
Supplements: Calcium	1.1	1.2	3.5	-0.5	0.4	-1.6	0.5	-1.2	-0.2	-1.9
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	1.0	-0.0	1.0	-0.1	-0.0	0.7	0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	0.1	-0.1	-0.2	-1.3	-0.8	-0.8	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.1	0.6	1.4	-0.2	0.8	1.3	0.2	-0.9
Heart disease (siblings)	0.5	0.6	2.0	0.7	0.3	-0.0	-1.4	-0.2	1.0	-0.7
Alcohol drinker status: Previous	0.6	0.7	2.0	-0.2	1.4	0.6	-0.8	-0.2	0.4	-1.2
Pack years of smoking	0.4	0.6	2.4	-0.3	-1.5	0.1	0.6	1.0	0.1	0.7
Impedance of whole body	0.1	0.7	1.5	-0.8	1.1	-1.2	0.4	-0.1	0.8	-1.0
Leg fat mass (left)	0.6	2.4	5.2	2.3	-2.1	1.9	1.8	-0.1	-0.2	0.4
Arm predicted mass (left)	0.2	1.2	3.8	-0.9	-0.4	-0.0	-1.0	-1.5	-1.9	-0.4