TWAS hub - SREK1IP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0895	0.0423	0.00900	0.044	NA	0.001	NA	0.028	0.00022	NA	0.2700	NA	0.0025
2	GTEx	Colon Transverse	0.1880	0.0750	0.00780	0.015	NA	0.018	NA	0.045	0.06200	NA	0.0460	NA	0.0035
3	NTR	Blood	0.0336	0.0134	0.00028	0.001	0.017	0.007	0.017	0.004	0.14000	2.9e-06	0.0024	2e-06	0.0190

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative body size at age 10	10.5	29.1	32.0	-5.5	-5.7	-5.0
Risk taking	4.5	6.6	8.1	2.9	2.3	2.5
Nervous feelings	4.4	8.2	14.0	2.5	3.7	2.0
Frequency of tiredness / lethargy in last 2 weeks	4.2	6.8	18.7	0.3	4.3	1.3
Tense / ‘highly strung’	4.1	6.7	12.9	0.6	3.6	2.6
Hearing aid user	3.8	4.3	11.0	1.2	3.3	0.5
Long-standing illness, disability or infirmity	3.6	5.5	12.5	1.5	3.5	1.3
Primary Biliary Cirrhosis	3.5	5.0	8.5	2.9	1.5	2.1
Falls in the last year	3.3	4.5	9.2	1.1	3.0	1.8
Unable to work because of sickness or disability	3.0	3.9	7.5	1.5	2.7	1.4
BMI	2.9	16.9	25.2	-5.0	-3.8	-3.3
Impedance of leg (right)	2.9	14.1	23.0	4.8	3.0	3.2
Impedance of leg (left)	2.9	14.1	21.2	4.6	2.8	3.6
Impedance of whole body	2.9	14.5	20.9	4.6	3.2	3.5
Worry (Nagel 2018)	2.8	6.0	9.1	2.0	3.0	2.2
Mother’s age at death	2.8	3.6	6.5	-1.7	-1.1	-2.6
Stomach or abdominal pain in last month	2.6	3.2	9.4	0.1	3.1	0.5
Had other major operations	2.6	3.1	9.0	0.6	3.0	0.2
Loneliness, isolation	2.6	3.6	7.6	1.0	2.8	1.4
Asthma (self-reported)	2.6	5.1	6.1	2.4	1.9	2.5
Pain experienced in last month	2.6	4.4	9.1	0.6	-3.0	-1.9
Lung FEV1/FVC ratio	2.5	12.5	22.4	-2.2	-4.7	-3.2
Medication: Lisinopril	2.5	3.2	5.8	1.5	1.3	2.4
Ever had prostate specific antigen (PSA) test	2.5	2.9	4.8	-2.2	-1.2	-1.5
Neuroticism	2.4	5.7	10.2	2.0	3.2	1.7
Frequency of depressed mood in last 2 weeks	2.4	3.4	9.7	-0.7	3.1	0.1
Neuroticism score	2.4	4.9	8.8	1.9	3.0	1.6
Asthma	2.4	4.7	5.5	2.3	1.8	2.3
Townsend deprivation index at recruitment	2.3	3.2	6.9	-1.1	-1.1	-2.6
Hearing difficulty/problems with background noise	2.3	3.7	6.1	-1.4	2.5	-1.7
Impedance of arm (left)	2.3	10.6	16.1	4.0	3.0	2.6
Angina	2.2	2.9	5.2	1.3	2.3	-1.4
Angina (self-reported)	2.2	2.9	5.9	1.1	2.4	-1.3
Commuting to job workplace: Car/motor vehicle	2.2	2.5	5.7	-0.1	1.3	2.4
Supplements: Vitamin C	2.2	2.6	5.9	-1.2	2.4	0.7
Commuting to job workplace: Public transport	2.2	2.7	6.6	-2.6	0.9	-0.8
Age started oral contraceptive pill	2.2	2.8	6.5	-1.4	0.1	-2.5
Heart disease (siblings)	2.2	2.7	5.8	-2.4	-0.4	-1.4
Depression (Nagel 2018)	2.1	3.1	8.4	-1.0	2.9	0.2
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	8.0	-0.6	2.8	-0.1
Medication: Co-codamol	2.1	2.5	3.6	0.9	1.9	1.7
Impedance of arm (right)	2.1	10.0	17.9	4.2	2.8	2.0
Medication: Ibuprofen	2.1	2.5	4.7	-2.2	0.6	-1.6
Medication: Seretide 50 evohaler	2.1	2.5	5.4	2.3	1.2	0.8
Guilty feelings	2.1	3.2	8.9	-0.0	3.0	0.9
Body mass index (BMI)	2.0	8.6	11.4	-3.4	-3.2	-2.0
Length of working week for main job	2.0	2.2	2.7	-1.6	-1.3	-1.5
Loud music exposure frequency	2.0	2.1	5.2	-1.0	-0.5	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.5	2.1	-0.5	-1.5
Diabetes (self-reported)	1.9	2.9	4.9	-0.1	-2.2	-2.0
Arm predicted mass (right)	1.9	9.5	16.2	-4.0	-2.5	-2.4
Friendships satisfaction	1.9	2.3	4.3	-2.1	-0.2	-1.6
Arm fat-free mass (left)	1.9	9.5	14.7	-3.8	-2.6	-2.6
Respiratory disease	1.8	3.9	6.2	2.5	0.7	2.3
Pulse rate	1.8	3.0	3.5	1.5	1.8	1.9
Arm fat-free mass (right)	1.8	9.1	16.0	-4.0	-2.4	-2.3
Emphysema/chronic bronchitis	1.8	2.0	2.5	-1.4	1.2	-1.6
Chest pain or discomfort	1.8	2.6	6.3	1.0	2.5	0.5
High cholesterol (Self-reported)	1.8	3.2	6.6	2.6	-1.8	-0.0
Leg fat-free mass (left)	1.7	8.9	12.5	-3.5	-2.6	-2.7
Leg predicted mass (left)	1.7	9.1	12.4	-3.5	-2.8	-2.7
Leg fat-free mass (right)	1.7	9.0	13.5	-3.7	-2.5	-2.6
Back pain experienced in last month	1.7	2.5	7.0	-0.1	2.6	0.6
Whole body water mass	1.7	10.0	15.6	-4.0	-2.5	-2.8
Leg predicted mass (right)	1.7	8.9	13.7	-3.7	-2.6	-2.5
Basal metabolic rate	1.7	9.3	14.3	-3.8	-2.5	-2.7
Neuroticism (Nagel 2018)	1.6	3.9	8.3	1.2	2.9	1.4
Rheumatoid Arthritis	1.6	2.2	5.4	-0.2	1.1	2.3
Schizophrenia (2014)	1.6	3.5	8.6	0.1	1.4	2.9
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	6.2	-0.0	2.5	1.2
Heart attack	1.6	2.0	4.7	0.8	2.2	0.9
Arm fat mass (right)	1.6	6.4	8.5	-2.9	-2.7	-1.9
Worry too long after embarrassment	1.6	2.6	7.0	0.9	2.6	0.3
Leg fat mass (right)	1.6	6.0	11.0	-2.2	-3.3	-1.4
Knee pain experienced in last month	1.6	2.5	4.8	-1.6	2.2	-0.4
Whole body fat-free mass	1.6	9.4	14.7	-3.8	-2.5	-2.7
Osteoporosis (self-reported)	1.6	2.0	3.2	1.6	1.8	0.5
Medication: Paracetamol	1.6	2.4	3.5	-1.7	1.9	-1.0
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.7	0.8	2.2	0.9
Systolic Blood Pressure	1.5	7.6	11.3	3.4	0.9	3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	5.0	-0.5	2.2	0.9
Taking other prescription medications	1.5	2.3	6.7	-0.3	2.6	0.2
Qualifications: CSEs or equivalent	1.5	2.0	3.9	-2.0	-1.1	-1.0
Supplements: Glucosamine	1.5	1.9	4.0	-1.3	-0.1	2.0
Happiness	1.5	1.8	3.8	-2.0	0.9	-0.8
Breastfed as a baby	1.5	1.8	4.6	-0.1	0.9	2.1
Arm fat mass (left)	1.5	6.1	8.0	-2.8	-2.7	-1.7
Leg fat mass (left)	1.5	5.9	10.2	-2.4	-3.2	-1.2
Arm predicted mass (left)	1.5	7.7	13.0	-3.6	-2.2	-2.3
Chronotype (morning person)	1.4	3.2	4.4	1.2	-2.1	-1.9
Waist circumference	1.4	5.1	7.3	-1.9	-2.7	-2.1
Past tobacco smoking	1.4	2.5	3.7	-0.5	1.9	1.9
Had menopause	1.4	1.7	2.3	-1.5	-1.5	-0.7
Weight	1.4	7.1	10.0	-3.2	-2.6	-2.1
Trunk fat-free mass	1.4	7.8	13.2	-3.6	-1.9	-2.6
Hip circumference	1.4	6.1	11.0	-3.3	-2.1	-1.7
Trunk predicted mass	1.4	7.8	13.1	-3.6	-1.8	-2.6
Exposure to tobacco smoke outside home	1.4	1.9	4.5	0.4	-1.0	-2.1
Medication for pain relief, constipation, heartburn	1.4	2.4	3.3	1.8	-1.1	1.7
Overall health rating	1.4	3.1	8.6	-0.4	2.9	-0.6
Smoking status: Current	1.4	2.3	5.0	0.7	-2.2	-1.2
Schizophrenia vs Biploar Disorder	1.3	1.6	3.7	-1.1	1.9	-0.2
Ovarian Cancer	1.3	1.7	3.2	-1.2	-0.6	-1.8
Lupus	1.3	1.9	4.9	0.8	-2.2	0.4
Current tobacco smoking	1.3	2.2	4.8	1.0	-2.2	-0.9
Financial difficulties in last 2 years	1.3	1.7	2.3	1.1	1.3	1.5
Medication: Ramipril	1.3	1.6	3.6	-0.6	-0.9	-1.9
Number of live births	1.3	1.9	3.8	1.2	1.9	0.7
Prospective memory result	1.3	1.6	2.3	-0.6	1.5	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.5	-1.6	-1.3	0.6
Financial situation satisfaction	1.3	1.7	2.6	-1.3	-1.6	-0.8
Ever smoked	1.3	2.4	3.7	1.0	-1.5	-1.9
Irritability	1.3	2.2	2.6	1.6	1.5	1.3
Alzheimer’s Disease (in father)	1.2	1.3	2.5	1.6	-0.5	1.1
Coronary Artery Disease (CAD)	1.2	1.4	2.1	-0.5	1.3	-1.5
Medication: Simvastatin	1.2	1.8	3.0	1.2	-1.7	-0.9
Health satisfaction	1.2	1.6	2.4	-1.6	1.5	-0.3
Heart disease (mother)	1.2	1.5	2.4	1.6	-1.1	0.9
Whole body fat mass	1.2	5.0	7.9	-2.4	-2.8	-1.3
Wears glasses or contact lenses	1.2	1.3	2.4	-0.8	-1.0	-1.6
Smoking Status	1.1	2.8	4.3	-0.7	-2.1	-1.9
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.2	-0.9	-2.0	-1.1
Sensitivity / hurt feelings	1.1	1.9	5.4	-0.0	2.3	0.6
Age when periods started (menarche)	1.1	2.7	6.2	1.4	0.1	2.5
Arm fat percentage (right)	1.1	4.3	5.8	-2.4	-2.4	-1.2
Medication: Lansoprazole	1.1	1.2	3.5	-0.1	1.9	-0.4
Illnesses of mother	1.1	1.4	2.7	-0.8	0.9	1.6
Peak expiratory flow (PEF)	1.1	2.6	4.3	-0.8	-1.7	-2.1
Medication: Paracetamol	1.1	1.8	3.2	-1.2	1.8	-0.8
Age at last live birth	1.1	1.5	3.3	-0.4	1.8	1.1
Illnesses of father: High blood pressure	1.1	1.4	2.1	0.2	1.4	1.4
Number of operations (self-reported)	1.1	1.7	2.9	0.1	1.7	-1.4
Medication: Metformin	1.0	1.4	2.5	0.4	-1.6	-1.2
Trunk fat mass	1.0	4.4	6.4	-2.3	-2.5	-1.1
Exposure to tobacco smoke at home	1.0	1.1	2.5	-0.9	0.1	-1.6
Headache pain in last month	1.0	1.7	4.1	-0.9	2.0	-0.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.8	1.7	-0.1	0.9
Had major operations	1.0	1.2	3.7	0.0	1.9	-0.0
Arm fat percentage (left)	1.0	3.9	5.3	-2.3	-2.3	-1.0
Diabetes diagnosed by doctor	1.0	1.6	2.6	-0.2	-1.6	-1.5
Number of self-reported non-cancer illnesses	1.0	1.7	4.1	0.8	2.0	0.6
Fractured/broken bones in last 5 years	1.0	1.3	2.8	0.0	1.0	1.7
Schizophrenia (2018)	0.9	1.9	4.7	0.7	0.7	2.2
Bipolar Disorder (2011)	0.9	0.8	1.2	0.7	0.9	1.1
Hearing difficulty/problems: Yes	0.9	1.3	1.6	-1.3	1.1	-1.1
Severe depression (siblings)	0.9	1.0	1.7	-1.1	0.2	-1.3
Allergy	0.9	2.1	3.0	-1.7	-1.7	-0.7
Pain all over the body in last month	0.9	1.0	1.3	1.2	0.7	1.0
Leg fat percentage (right)	0.9	3.1	7.1	-1.4	-2.7	-0.5
Number of children fathered	0.9	1.1	2.0	-0.4	1.0	1.4
Age at first live birth	0.9	1.7	3.2	-1.8	1.2	0.6
Pulse rate, automated reading	0.9	2.9	5.9	1.3	1.0	2.4
Number of full sisters	0.9	1.1	1.9	0.9	-0.8	-1.4
Medication: Aspirin	0.9	1.2	3.0	-0.5	-0.7	-1.7
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.7	-1.2	-0.4	-1.3
Medication: Aspirin	0.9	1.2	2.7	-0.2	-1.0	-1.6
Hair/balding pattern: Pattern 4	0.8	1.9	4.4	1.1	-2.1	0.5
Birth weight of first child	0.8	1.5	2.7	-1.6	0.0	-1.4
Glaucoma (self-reported)	0.8	0.9	1.7	0.8	0.6	1.3
Number of full brothers	0.8	1.0	1.6	1.3	0.8	0.9
Wheeze or whistling in the chest in last year	0.8	1.4	2.0	1.4	1.4	0.4
Suffer from ‘nerves’	0.8	1.3	2.4	1.6	1.2	0.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.8	-0.2	1.7	0.5
Leg fat percentage (left)	0.8	2.9	6.4	-1.5	-2.5	-0.2
Vitamin and mineral supplements	0.7	0.9	2.7	1.6	-0.0	-0.4
Serious illness, injury or assault to yourself	0.7	0.8	2.2	0.5	0.2	-1.5
Body fat percentage	0.7	2.6	4.9	-1.6	-2.2	-0.6
Leg pain on walking	0.7	0.9	2.3	0.4	1.5	0.3
Mineral and other dietary supplements	0.7	0.9	2.5	1.6	0.5	0.2
Breast cancer (self-reported)	0.7	0.9	2.0	-0.6	1.4	0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	0.1	0.6	1.4
Medication: Blood pressure	0.7	1.4	3.9	0.3	2.0	0.4
Supplements: Calcium	0.7	0.8	1.9	-0.4	-1.4	0.6
Depressed Affect (Nagel 2018)	0.6	1.2	2.3	1.0	1.5	0.5
Age at First Birth	0.6	0.9	1.8	-0.4	0.8	1.3
Waist Hip Ratio (WHR)	0.6	2.7	7.7	2.8	0.6	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.9	-0.6	-1.4	-0.3
Systolic blood pressure, automated reading	0.6	1.9	3.5	1.4	-0.1	1.9
Trunk fat percentage	0.6	2.5	4.5	-1.7	-2.1	-0.6
Average weekly fortified wine intake	0.6	0.7	1.6	-1.2	0.6	-0.5
Fed-up feelings	0.6	1.1	2.7	1.7	0.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.0	-1.7	0.0	-0.6
Pulse wave peak to peak time	0.6	0.7	1.1	-0.9	-0.3	-1.1
Eye problems/disorders: None of the above	0.6	0.7	1.4	0.5	-1.2	0.6
Neck or shoulder pain in last month	0.6	0.8	2.5	-1.6	-0.0	-0.1
Migraine (self-reported)	0.6	0.8	1.3	-1.0	0.0	1.1
Medication: Allopurinol	0.6	0.8	2.0	1.4	-0.4	0.5
Family relationship satisfaction	0.6	0.8	1.7	-1.3	-0.0	-0.8
Ever had bowel cancer screening	0.6	0.7	1.1	-1.1	0.7	-0.8
Qualifications: nursing, teaching	0.6	0.9	2.2	0.7	0.3	1.5
Medication: Gliclazide	0.6	0.7	0.9	-0.9	-0.5	-1.0
Illnesses of father: None of the above (group 1)	0.6	0.7	1.9	0.4	-1.4	-0.2
Average weekly champagne plus white wine intake	0.6	0.8	1.6	-0.1	-1.3	-0.9
Ever taken oral contraceptive pill	0.6	0.6	1.8	1.3	-0.3	0.2
Alcohol drinker status: Previous	0.6	0.6	1.1	-1.1	-0.2	0.9
Body Mass Index (BMI) (2010)	0.5	0.6	1.3	-1.1	-0.8	-0.2
Mean Putamen Volume	0.5	0.5	1.2	-0.7	-1.1	0.0
Number of treatments/medications taken	0.5	0.8	1.4	-0.3	1.2	-1.0
Diabetes (father)	0.5	0.7	1.1	-1.0	-0.4	0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	0.7	0.8	0.6	-0.9
Hair/balding pattern: Pattern 3	0.5	0.7	0.8	-0.9	-0.7	-0.8
Noisy workplace	0.5	0.7	1.2	-0.9	-0.2	-1.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.4	-0.2	-1.2	-1.1
Medication: Cholesterol lowering	0.5	0.8	1.0	0.7	-1.0	-1.0
Lung cancer (father)	0.5	0.6	1.5	0.3	1.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	1.2	0.9	0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.8	-0.4	0.2	-1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.7	2.2	-0.2	1.5	-0.2
Birth weight	0.5	1.1	1.9	-1.1	-0.3	-1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	-0.0	0.2	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	0.4	1.3	-0.3
Commuting to job workplace: Walk	0.5	0.5	0.8	0.4	-0.8	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	-1.2	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.5	-0.3	0.8	1.6
Average weekly beer plus cider intake	0.5	0.7	0.9	0.7	0.9	0.7
Myopia	0.5	0.7	1.8	-0.1	-0.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.8	-0.9	0.5	-0.8
Bipolar Disorder (2018)	0.4	0.6	1.2	-1.1	-0.7	-0.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.8	-0.2	0.1	1.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	-0.2	1.1	-0.4
Major Depression (MDD)	0.4	0.5	0.8	0.9	0.2	0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.4	1.2	-0.8	0.8
LDL Cholesterol	0.4	0.7	1.5	-1.2	0.1	-0.7
Neuroticism (2016)	0.4	0.6	1.2	0.1	0.8	1.1
Triglycerides	0.4	0.6	1.1	-1.0	0.3	-0.8
Average weekly spirits intake	0.4	0.5	0.7	0.8	0.8	0.5
Medication for hormone replacement therapy	0.4	0.5	1.0	0.6	-1.0	-0.3
Supplements: Zinc	0.4	0.4	1.0	1.0	-0.6	-0.2
Pack years adult smoking proportion	0.4	0.7	1.5	1.2	-0.5	-0.5
Hand grip strength (right)	0.4	1.2	2.9	-0.3	0.7	1.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.0	-0.6	-0.2	-1.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	-0.5	-1.0	-0.0
Multivitamins +/- minerals	0.4	0.5	0.8	-0.7	-0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.6	-0.7	0.7	-0.8
High blood pressure (mother)	0.4	0.6	0.8	-0.1	-0.9	-0.9
Number of incorrect matches in round	0.4	0.6	1.4	-1.2	-0.6	-0.3
Alcohol usually taken with meals	0.4	0.6	1.1	1.0	-0.6	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	-0.3	1.1	-0.4
Mouth/teeth dental problems	0.4	0.6	1.9	0.1	0.3	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.6	0.8	0.7	0.7
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-1.0	-0.7	-0.5
Worrier / anxious feelings	0.4	0.7	1.3	0.5	1.1	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	-0.9	-0.7	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.7	-0.7	0.8	-0.4
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	0.8	0.1	1.0
Blood clot in the leg (DVT)	0.4	0.5	1.3	0.3	0.3	-1.2
Medication: Omeprazole	0.4	0.5	0.8	-0.4	0.8	-0.9
Smoking status: Previous	0.4	0.6	1.0	0.2	-1.0	-0.8
Mood swings	0.4	0.7	1.5	0.6	1.2	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.1	-1.0	0.3	-0.7
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	0.3	-0.2	1.2
Cholesterol lowering medication	0.4	0.5	0.9	0.8	-0.0	0.9
Pack years of smoking	0.4	0.6	1.3	1.1	-0.2	-0.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.1	0.2	-1.5	-0.8
Crohns Disease (2017)	0.3	0.7	1.1	1.0	-1.1	-0.1
Breast Cancer	0.3	0.8	1.9	-0.4	-1.4	-0.5
Blood Eosinophil Count	0.3	2.0	2.2	1.5	-1.4	-1.3
Blood White Count	0.3	2.5	3.6	1.8	-0.9	1.9
Tanning	0.3	3.5	8.4	2.9	0.2	1.5
Relative age of first facial hair	0.3	0.6	0.7	0.7	-0.9	-0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	-0.5	-0.4	-0.8
Relative age voice broke	0.3	0.5	1.1	1.0	0.6	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.6	-0.5	-1.3	-1.1
Medication: Amlodipine	0.3	0.5	0.9	0.9	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.7	0.4	0.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.8	0.4	0.6
Shortness of breath walking on level ground	0.3	0.4	1.0	-0.0	1.0	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.1	0.5	1.0
Illnesses of siblings: Diabetes	0.3	0.4	1.0	0.5	-0.1	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	-0.7	-0.9	-0.2
Medication: Bendroflumethiazide	0.3	0.4	0.8	-0.9	-0.0	-0.6
Ever depressed for a whole week	0.3	0.4	0.5	-0.5	-0.7	-0.7
Commuting to job workplace: Cycle	0.3	0.4	0.5	-0.6	-0.5	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	0.2	-1.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.6	0.3	-0.9
Irritable Bowel Disease (IBD)	0.2	0.6	1.1	1.1	-0.5	0.5
Ulcerative Colitis (UC)	0.2	0.3	0.7	0.5	-0.0	0.8
Reaction Time	0.2	0.4	0.7	0.5	0.9	-0.5
Crohns Disease (2012)	0.2	0.4	0.7	0.1	-0.8	0.6
HDL Cholesterol	0.2	0.4	0.5	0.7	0.3	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.8	0.1	0.3
Ulcerative Colitis	0.2	0.3	0.6	0.1	0.4	0.8
Blood Red Count	0.2	1.8	2.7	-0.1	1.6	1.6
Heel T-Score	0.2	1.4	2.0	-1.1	1.0	-1.4
Hypothyroidism (self reported)	0.2	0.5	0.7	-0.5	0.7	0.9
Hand grip strength (left)	0.2	0.6	0.9	-0.2	0.9	0.9
Maternal smoking around birth	0.2	0.3	0.5	0.7	0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.5	-0.5	-0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.4	0.2	-0.6
Qualifications: None of the above	0.2	0.5	1.2	0.2	0.6	-1.1
Fluid intelligence score	0.2	0.4	1.1	0.1	-1.0	0.1
Illnesses of siblings	0.2	0.3	0.8	0.1	-0.3	0.9
Time employed in main current job	0.2	0.3	0.7	-0.8	-0.4	-0.0
Depression (self-reported)	0.2	0.3	0.5	-0.7	-0.4	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.9	-0.3	0.4
Medication: Blood pressure	0.2	0.3	0.6	0.7	-0.8	0.2
Comparative height size at age 10	0.2	1.3	2.4	-1.5	0.9	-0.8
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.5	0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.3	-0.5	-0.5	-0.5
Eye problems/disorders: Cataract	0.2	0.3	0.7	-0.2	0.9	0.1
Medication: Atorvastatin	0.2	0.3	0.6	0.5	0.8	0.2
Diastolic blood pressure, automated reading	0.2	0.7	1.9	-1.4	-0.5	0.1
Prostate Cancer	0.1	0.2	0.5	0.0	-0.3	-0.7
Fasting Glucose	0.1	0.1	0.1	0.1	0.3	0.3
HbA1C	0.1	0.1	0.2	-0.3	-0.2	-0.5
Blood Platelet Count	0.1	0.8	2.1	-1.4	-0.1	-0.5
Allergy or Eczema	0.1	0.4	1.1	1.0	0.2	-0.2
Diabetes (mother)	0.1	0.1	0.2	0.2	-0.5	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.9	1.0	0.1	0.1
Medication: Atenolol	0.1	0.2	0.2	0.5	-0.5	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.4	0.7	-0.2
Sitting height	0.1	0.9	1.5	-0.9	1.2	-0.5
Forced vital capacity (FVC)	0.1	0.3	0.9	-0.1	0.1	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.0	-0.8	-0.4
Father’s age at death	0.1	0.1	0.1	0.1	-0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	0.1	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	0.1	-0.7	-0.3
Pulse wave reflection index	0.1	0.1	0.1	-0.1	0.3	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	0.0	0.0	-0.7
Gout (self-reported)	0.1	0.1	0.2	0.4	-0.3	0.4
High blood pressure (siblings)	0.1	0.2	0.3	0.6	0.5	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.6	0.0	0.8	-0.1
Qualifications: College or University degree	0.1	0.3	0.7	0.9	0.3	0.2
Mean time to correctly identify matches	0.1	0.2	0.6	-0.2	0.7	-0.2
Alcohol intake frequency.	0.1	0.3	0.8	-0.9	0.4	-0.2
Hypertension (Self-reported)	0.1	0.2	0.5	-0.2	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.6	-0.0	-0.4
Average weekly red wine intake	0.1	0.1	0.2	0.4	-0.2	0.1
Medication for cholesterol	0.1	0.2	0.3	-0.5	0.1	0.5
Miserableness	0.1	0.1	0.2	0.3	0.5	0.2
Alcohol drinker status: Never	0.1	0.1	0.2	0.0	0.2	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.9	0.2	-1.0	-0.0
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	-0.1	0.2	-0.1
Height	0.0	0.3	0.5	0.7	0.7	0.0
Cardiovascular Disease	0.0	0.0	0.0	0.0	-0.0	-0.2
Lung FVC	0.0	0.0	0.0	-0.2	0.2	-0.1
Hair Pigment	0.0	0.9	1.3	1.1	1.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.1	-0.0	-0.0
High blood pressure	0.0	0.1	0.2	-0.4	0.4	-0.1
Standing height	0.0	0.4	1.0	-0.2	1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.2	-0.4	0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.2	0.1	-0.2

Hub : Genes

SREK1IP1

Models

Trait associations