Hub : Genes

SS18

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2890	0.1210	0.00068	-0.009	NA	0.080	NA	0.027	8.8e-01	NA	0.00140	NA	0.0450
2	TCGA	Breast Invasive Carcinoma	0.0313	0.0169	0.00059	0.023	0.01	0.017	NA	0.015	1.1e-05	0.0025	0.00015	NA	0.0003
3	TCGA	Cervical Squamous Cell Carcinoma	0.0630	0.0370	0.00680	0.055	0.04	0.030	NA	0.029	1.1e-03	0.0046	0.01200	NA	0.0140

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.1	1.7	0.1	-1.3	-1.2
Bipolar Disorder or Schizophrenia	0.8	1.9	3.1	-1.8	-0.7	-1.4
Depressed Affect (Nagel 2018)	2.4	5.0	6.0	-2.2	-2.4	-2.1
Depression (Nagel 2018)	0.8	1.2	2.2	-1.2	-1.5	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	0.6	-0.4	1.0
Neuroticism (Nagel 2018)	1.9	4.4	5.2	-1.9	-2.3	-2.1
Schizophrenia (2018)	0.9	1.8	4.7	-2.2	0.1	-0.9
Schizophrenia vs Biploar Disorder	1.8	2.3	5.8	-2.4	0.8	0.8
Worry (Nagel 2018)	2.1	4.4	8.1	-2.0	-2.8	-1.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	0.3	-0.6	-0.8
Alzheimer’s Disease (in father)	1.6	1.7	2.5	-1.2	-1.6	-1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	-0.6	-1.3	-1.1
Crohns Disease (2017)	0.1	0.2	0.4	-0.0	-0.5	-0.6
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.1	-0.1	-0.2
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.3	0.7	0.8
Major Depression (MDD)	0.1	0.2	0.5	0.1	0.7	-0.1
Reaction Time	0.4	0.7	1.4	-1.2	0.8	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.9	0.8	-0.9	1.4
Breast Cancer	0.9	2.1	5.4	-0.8	-2.3	0.6
Ovarian Cancer	0.4	0.6	1.3	-1.1	-0.6	-0.1
Prostate Cancer	1.5	2.1	4.4	1.2	0.6	2.1
Age at First Birth	1.0	1.5	4.1	-2.0	-0.6	0.1
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.3	0.0	0.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-1.2	-0.2	-0.8
Coronary Artery Disease (CAD)	2.9	3.5	6.3	-1.4	-2.5	-1.5
Crohns Disease (2012)	0.4	0.6	1.6	-0.4	-1.3	0.2
Mean Putamen Volume	0.0	0.0	0.1	-0.1	0.0	-0.3
Fasting Glucose	1.3	1.6	4.1	0.6	-0.5	-2.0
HbA1C	0.6	0.7	1.2	1.1	0.8	-0.4
HDL Cholesterol	0.2	0.4	0.8	-0.9	-0.4	-0.5
LDL Cholesterol	0.7	1.2	3.5	-1.9	-0.1	0.1
Lupus	0.2	0.3	0.6	0.7	-0.4	0.3
Neuroticism (2016)	0.2	0.4	0.9	0.4	0.9	0.2
Primary Biliary Cirrhosis	0.3	0.5	1.1	-0.0	1.1	0.6
Rheumatoid Arthritis	0.8	1.1	1.5	1.2	1.2	0.6
Schizophrenia (2014)	0.5	1.0	2.0	-1.4	0.1	-1.0
Triglycerides	0.5	0.8	2.3	-0.1	-1.5	-0.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	-0.4	-0.8	-1.4
Ulcerative Colitis	0.5	0.7	1.2	-0.8	-1.1	-0.5
Blood Eosinophil Count	0.1	0.9	2.4	-0.3	0.4	1.5
Blood Platelet Count	0.4	4.6	11.7	-0.7	-3.4	-1.2
Blood Red Count	1.5	14.5	23.9	4.0	4.9	2.0
Blood White Count	0.9	7.0	16.1	-0.9	-4.0	-2.0
Heel T-Score	0.1	0.9	2.2	-0.4	1.5	-0.5
BMI	0.9	5.4	11.5	-1.0	1.9	-3.4
Height	2.2	41.8	61.0	3.6	7.2	7.8
Waist Hip Ratio (WHR)	1.1	5.1	5.4	2.3	2.2	2.3
Systolic Blood Pressure	0.5	2.6	6.1	0.2	-1.3	-2.5
Smoking Status	0.5	1.3	2.0	1.2	1.4	0.6
Allergy or Eczema	0.6	1.7	3.1	-0.7	-1.8	-1.2
Cardiovascular Disease	0.4	1.4	1.7	-1.3	-1.3	-0.9
Hypothyroidism (self reported)	3.6	8.2	23.0	1.0	4.8	0.8
Respiratory disease	0.8	1.7	4.4	0.9	-0.2	-2.1
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.5	0.3	-1.2	-1.6
Lung FEV1/FVC ratio	0.3	1.5	3.7	-0.3	1.9	0.9
Lung FVC	0.2	1.0	1.5	1.2	-1.0	-0.7
Neuroticism	3.8	9.1	14.0	-2.6	-3.7	-2.6
Chronotype (morning person)	0.8	1.8	3.1	-1.4	-1.8	-0.4
Hair Pigment	0.0	1.3	2.2	-0.0	-1.3	-1.5
Tanning	0.3	3.8	5.7	-1.5	-2.4	-1.9
Hand grip strength (left)	0.1	0.4	1.1	1.1	0.1	0.2
Number of treatments/medications taken	0.6	1.0	1.8	-1.4	-0.9	-0.7
Average weekly spirits intake	1.0	1.2	2.9	-0.4	-1.7	-0.7
Sensitivity / hurt feelings	0.7	1.2	2.9	0.5	-0.6	-1.7
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.8	-1.3	-1.3	-0.4
Hearing difficulty/problems: Yes	0.1	0.2	0.2	-0.4	0.4	0.3
Relative age of first facial hair	0.3	0.6	1.1	1.1	0.6	-0.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.6	0.1	1.3	-1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.7	-0.6	-0.8	0.7
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	-0.3	-0.6	-1.0
Systolic blood pressure, automated reading	1.9	5.4	14.4	-0.7	-1.2	-3.8
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.7	0.7	-0.8	-1.3
Angina	1.2	1.6	3.4	-0.6	-1.0	-1.9
Medication for hormone replacement therapy	0.7	0.8	1.5	-1.2	-0.9	-0.1
Vitamin and mineral supplements	0.1	0.1	0.2	0.2	0.4	0.4
Supplements: Zinc	0.6	0.6	1.7	0.1	-0.3	1.3
Medication: Co-codamol	0.8	0.9	1.4	-1.2	-0.8	-0.9
Medication: Metformin	0.4	0.6	1.2	0.5	1.1	-0.6
Diabetes (father)	0.9	1.1	1.7	-1.3	-1.3	0.2
Diabetes (mother)	0.2	0.2	0.4	0.7	0.2	-0.4
Severe depression (siblings)	2.2	2.4	2.7	1.6	1.4	1.6
Pack years adult smoking proportion	2.0	3.1	5.4	-1.3	-2.3	-1.5
Impedance of leg (right)	0.6	3.0	7.8	1.0	-0.3	2.8
Leg fat-free mass (left)	0.4	2.3	6.6	0.3	2.6	-0.4
Trunk fat percentage	0.4	1.7	4.1	-0.0	0.9	-2.0
Hand grip strength (right)	0.5	1.4	2.6	1.0	0.9	1.6
Townsend deprivation index at recruitment	1.3	1.8	2.9	1.7	0.4	-1.6
Current tobacco smoking	0.3	0.5	0.8	-0.0	-0.9	0.9
Average weekly fortified wine intake	0.8	0.9	1.9	0.6	1.4	-0.7
Maternal smoking around birth	1.0	1.4	1.8	-1.4	-0.8	-1.3
Fed-up feelings	3.1	5.7	5.9	-2.4	-2.4	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	-0.4	-1.2	-0.7
Relative age voice broke	1.0	1.5	2.1	1.4	1.2	-0.9
Taking other prescription medications	0.3	0.4	0.7	-0.8	0.7	-0.2
Age when periods started (menarche)	0.2	0.6	0.9	-0.3	0.9	0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.1	-0.2	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.1	2.0	1.1	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.3	-0.3	1.1	0.1
Qualifications: CSEs or equivalent	2.3	3.0	4.8	-0.8	-2.2	-1.9
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.2	0.0	-0.4
High blood pressure	2.4	6.6	7.7	-2.8	-2.3	-2.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-0.8	-1.4	0.2
Multivitamins +/- minerals	0.2	0.2	0.6	-0.3	-0.3	-0.8
Stomach or abdominal pain in last month	0.3	0.4	0.9	-1.0	-0.3	-0.2
Supplements: Glucosamine	0.2	0.3	0.4	-0.7	-0.6	0.3
Diverticular disease/diverticulitis (self-reported)	3.8	4.5	11.8	-3.4	-1.0	-0.8
Medication: Atenolol	0.8	1.0	2.5	-0.3	0.7	-1.6
Medication: Levothyroxine sodium	3.0	5.1	13.8	0.1	3.7	1.3
Sitting height	0.5	3.3	5.5	1.7	2.3	1.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.1	-0.4	-0.5
High blood pressure (mother)	0.7	0.9	1.6	0.0	-1.3	-1.1
Body mass index (BMI)	1.1	4.8	12.6	-1.0	0.9	-3.5
Impedance of leg (left)	0.9	4.3	11.0	1.4	-0.1	3.3
Leg predicted mass (left)	0.4	2.3	6.7	0.2	2.6	-0.4
Trunk fat mass	0.5	2.3	3.6	0.4	1.9	-1.7
Waist circumference	1.0	3.6	7.2	1.1	2.7	-1.5
Number of incorrect matches in round	0.4	0.7	1.3	-0.3	-1.1	-0.9
Past tobacco smoking	1.4	2.5	4.5	-1.3	-2.1	-1.1
Alcohol usually taken with meals	0.3	0.5	0.9	-0.9	-0.0	-0.7
Nervous feelings	1.4	2.7	3.5	-1.0	-1.8	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-1.1	-0.7	-0.4
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.2	-0.1	-0.1
Hair/balding pattern: Pattern 2	0.6	0.7	2.0	0.1	-1.4	-0.4
Had menopause	0.9	1.1	2.8	-0.1	-1.7	-0.7
Had other major operations	0.1	0.2	0.4	-0.1	0.3	-0.6
Forced vital capacity (FVC)	0.7	2.7	5.1	2.3	1.5	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.1	1.4	1.1	0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	-1.2	0.6	0.0
Qualifications: None of the above	0.7	1.6	1.8	-1.1	-1.3	-1.3
Financial difficulties in last 2 years	0.3	0.4	0.8	-0.9	0.5	0.1
Mouth/teeth dental problems	1.2	1.8	2.9	0.4	1.7	1.5
Heart attack	0.3	0.4	0.7	-0.7	-0.8	0.2
Allergy	0.3	0.7	1.0	0.2	1.0	1.0
Pain all over the body in last month	2.5	2.7	3.2	-1.8	-1.8	-1.3
Diabetes (self-reported)	1.4	2.2	4.8	-0.4	-1.3	-2.2
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	5.9	-0.5	-2.4	0.6
Medication: Ramipril	0.4	0.5	0.7	0.8	0.3	-0.9
Medication: Simvastatin	0.1	0.1	0.3	0.4	-0.1	-0.5
Fluid intelligence score	0.3	0.6	1.2	1.1	-0.8	0.3
Illnesses of siblings	0.3	0.4	0.6	0.6	0.3	-0.8
Neuroticism score	2.1	4.5	6.4	-2.0	-2.5	-1.7
Weight	0.6	3.2	7.6	0.3	2.8	-1.3
Impedance of arm (right)	0.1	0.5	1.1	0.3	-0.6	1.0
Arm fat percentage (right)	1.1	4.2	10.9	-0.5	1.1	-3.3
Trunk fat-free mass	0.9	5.1	12.5	1.0	3.5	1.3
Hip circumference	0.7	3.0	6.6	-0.1	1.5	-2.6
Time employed in main current job	0.8	1.0	2.0	0.8	0.5	1.4
Alcohol intake versus 10 years previously	0.6	1.0	1.6	-0.3	1.1	1.3
Father’s age at death	0.7	0.9	2.3	0.1	1.5	0.7
Worrier / anxious feelings	0.5	1.0	2.9	-0.3	-1.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.2	-1.2	-0.8	-1.8
Falls in the last year	1.1	1.5	3.5	-0.3	-1.0	1.9
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.3	0.6	-0.4
Number of live births	0.5	0.7	1.7	-0.1	-0.6	1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	4.4	1.9	2.1	1.2
Pulse rate	1.2	2.0	3.1	1.7	-0.2	1.8
Happiness	1.0	1.2	1.9	-1.4	-0.3	1.2
Noisy workplace	1.0	1.2	3.0	-1.7	-0.3	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	0.9	0.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	4.8	5.5	10.2	2.2	1.1	3.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.2	-0.6	-0.8
Asthma	1.0	1.9	4.9	-0.1	-1.0	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.1	1.0	0.9	0.7
Medication: Cholesterol lowering	2.2	3.4	7.6	-0.6	-2.8	-1.6
Depression (self-reported)	0.5	0.6	0.8	0.9	0.9	-0.4
Medication: Lansoprazole	1.1	1.2	2.9	-1.7	-0.6	-0.6
Prospective memory result	0.6	0.8	0.9	1.0	-0.7	-0.9
Lung cancer (father)	1.7	1.9	3.9	-1.2	-2.0	-0.6
Illnesses of mother	2.5	3.1	6.7	0.2	2.6	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.0	1.7	1.3	1.2
Pulse wave Arterial Stiffness index	2.2	2.6	4.3	1.1	2.1	1.5
Impedance of arm (left)	0.2	0.7	1.6	0.1	-1.3	0.8
Arm fat mass (right)	0.8	3.4	6.8	-0.2	1.8	-2.6
Trunk predicted mass	0.9	5.3	13.0	1.0	3.6	1.3
Standing height	1.7	16.5	22.0	3.1	4.2	4.7
Length of working week for main job	2.0	2.2	6.6	-0.0	-2.6	-0.0
Exposure to tobacco smoke at home	0.9	1.0	1.7	-1.3	0.6	-1.0
Breastfed as a baby	1.1	1.4	2.0	1.3	1.4	0.6
Tense / ‘highly strung’	3.6	6.0	9.3	-2.2	-3.0	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.3	-1.5	-1.2	-1.1
Hair/balding pattern: Pattern 4	1.6	3.8	7.9	1.7	2.8	0.9
Birth weight of first child	0.1	0.2	0.2	-0.5	0.5	0.1
Peak expiratory flow (PEF)	1.8	4.1	6.7	1.9	2.6	1.4
Pulse wave reflection index	0.3	0.4	1.1	-0.3	1.0	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.5	-0.7	0.0
Loud music exposure frequency	1.4	1.5	3.6	0.1	-0.9	-1.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.4	0.3	1.6	-0.3
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.3	-1.8	-1.3	-0.7
Blood clot in the leg (DVT)	0.8	1.0	2.8	-0.3	1.7	0.3
Medication: Paracetamol	0.5	0.7	1.5	-0.1	-0.8	-1.2
Headache pain in last month	0.9	1.6	3.3	0.8	-0.9	-1.8
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.9	0.3	2.0	1.5
Glaucoma (self-reported)	0.2	0.3	0.6	-0.4	0.8	-0.2
Gout (self-reported)	1.9	2.7	5.4	-1.6	-2.3	-0.4
Hypothyroidism/myxoedema (self-reported)	3.5	6.8	19.4	0.7	4.4	0.7
Medication: Amlodipine	0.9	1.2	2.9	-0.4	-1.7	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.5	-0.4	-0.7
Birth weight	1.3	2.7	4.3	1.1	1.7	2.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.6	-1.9	-0.3	-0.6
High blood pressure (siblings)	0.3	0.5	1.0	-0.4	-1.0	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.1	3.8	2.0	1.2	1.0
Body fat percentage	0.7	2.8	7.3	-0.1	1.0	-2.7
Leg fat percentage (right)	1.1	4.1	10.6	-0.9	1.0	-3.2
Arm fat-free mass (right)	0.6	3.2	8.4	0.8	2.9	0.7
Exposure to tobacco smoke outside home	1.0	1.3	3.0	1.7	0.7	-0.8
Comparative body size at age 10	0.7	2.0	4.5	-0.7	1.0	-2.1
Number of full brothers	0.2	0.3	0.8	-0.1	-0.2	0.9
Worry too long after embarrassment	0.1	0.2	0.4	0.6	0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.7	-1.3	-0.3	0.7
Wheeze or whistling in the chest in last year	0.7	1.2	2.7	-1.0	-0.1	-1.6
Number of children fathered	1.7	2.0	4.9	-2.2	-0.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.3	-1.1	-1.1	-0.4
Age at first live birth	0.4	0.6	1.2	1.1	0.7	0.5
Pulse wave peak to peak time	1.7	2.0	3.6	-0.8	-1.9	-1.4
Health satisfaction	0.1	0.1	0.2	-0.1	0.4	-0.3
Shortness of breath walking on level ground	1.0	1.1	2.0	-1.1	-0.5	-1.4
Qualifications: College or University degree	1.2	3.9	5.8	2.4	2.1	1.2
Eye problems/disorders: None of the above	1.4	1.6	3.2	0.8	1.1	1.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.9	-1.4	0.3	-1.3
Emphysema/chronic bronchitis	0.9	1.0	2.3	1.5	0.7	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.3	2.5	0.5	1.1	1.6
Neck or shoulder pain in last month	0.3	0.4	0.9	-1.0	0.5	0.1
Medication: Blood pressure	1.2	2.2	3.3	-0.6	-1.7	-1.8
Angina (self-reported)	1.4	1.8	3.7	-0.7	-1.1	-1.9
Migraine (self-reported)	2.0	2.5	3.5	-1.9	-1.6	-1.3
Medication: Ibuprofen	0.5	0.6	0.8	0.8	0.6	0.9
Medication: Allopurinol	1.3	1.8	3.9	-1.1	-2.0	0.4
Medication: Omeprazole	0.7	0.9	1.7	-0.9	0.3	-1.3
Medication: Seretide 50 evohaler	0.5	0.6	1.2	0.1	1.1	-0.7
Mean time to correctly identify matches	0.4	0.8	1.1	-1.1	0.9	-0.6
Heart disease (mother)	0.1	0.2	0.3	-0.3	-0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.5	-0.8	-1.6	-1.2
Whole body fat mass	0.6	2.6	4.5	0.1	1.8	-2.1
Leg fat mass (right)	0.8	2.9	5.2	-0.3	1.9	-2.3
Arm predicted mass (right)	0.6	3.2	7.4	1.2	2.7	0.8
Pulse rate, automated reading	0.6	2.1	5.0	2.2	-0.2	1.1
Alcohol intake frequency.	0.2	0.4	0.7	0.6	-0.8	-0.0
Comparative height size at age 10	1.1	6.1	10.7	0.3	2.7	3.3
Number of full sisters	2.3	2.7	5.7	2.4	1.2	1.1
Suffer from ‘nerves’	1.4	2.2	3.3	-1.3	-1.3	-1.8
Overall health rating	2.8	6.0	7.2	-2.1	-2.5	-2.7
Chest pain or discomfort	0.7	1.1	1.5	1.1	1.2	0.6
Had major operations	0.2	0.2	0.5	-0.1	-0.7	-0.2
Age at last live birth	0.8	1.2	3.1	0.5	1.8	0.4
Family relationship satisfaction	0.3	0.4	1.1	-0.2	-0.2	1.0
Leg pain on walking	0.7	0.8	1.1	-0.7	-1.0	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.6	0.5	-1.0
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.3	-2.1	-0.6	0.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.9	1.7	-0.5	-1.0
Medication: Aspirin	0.3	0.3	0.5	-0.4	-0.7	-0.6
Supplements: Vitamin C	0.4	0.5	0.9	0.6	-1.0	-0.4
Knee pain experienced in last month	0.4	0.6	1.7	-1.3	0.3	-0.0
Hypertension (Self-reported)	1.9	5.1	6.3	-2.3	-2.0	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	-0.7	0.1	-0.1
Illnesses of father: Heart disease	2.1	2.9	4.4	-2.1	-2.1	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.8	0.9	0.2
Smoking status: Previous	1.6	2.5	6.0	1.0	2.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.8	10.7	1.8	1.9	3.3
Whole body fat-free mass	0.7	3.8	10.6	0.7	3.3	0.6
Leg fat-free mass (right)	0.4	2.4	6.9	0.4	2.6	-0.1
Arm fat percentage (left)	1.1	4.6	12.7	-0.7	0.6	-3.6
Average weekly red wine intake	5.9	8.7	12.9	3.6	3.2	1.7
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.9	2.2	0.5	-0.6
Mood swings	2.4	4.3	7.2	-2.7	-2.0	-1.3
Loneliness, isolation	3.0	4.2	7.8	-1.6	-1.4	-2.8
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.3	0.5	0.1
Ever had bowel cancer screening	4.3	5.1	8.2	-2.9	-2.6	-0.4
Diabetes diagnosed by doctor	1.6	2.6	5.5	-0.8	-1.3	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	-0.8	0.2	1.1
Friendships satisfaction	0.8	1.0	2.0	-0.8	-1.4	0.6
Qualifications: nursing, teaching	1.6	2.5	4.5	0.8	1.5	2.1
Commuting to job workplace: Walk	3.3	3.6	9.9	3.2	0.9	-0.2
Eye problems/disorders: Cataract	1.2	1.4	2.9	-0.5	-1.7	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.8	0.5	-1.7	1.1
Medication for cholesterol	0.4	0.7	1.0	1.0	0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	-0.3	-0.6	-0.7
Back pain experienced in last month	0.3	0.4	0.8	-0.5	-0.9	-0.5
Mineral and other dietary supplements	0.2	0.3	0.9	-0.1	0.2	-1.0
Breast cancer (self-reported)	1.1	1.3	3.2	1.8	-0.4	0.7
Asthma (self-reported)	0.9	1.8	4.5	-0.1	-0.9	-2.1
Osteoporosis (self-reported)	0.8	1.0	2.3	-1.5	-0.8	-0.0
Osteoarthritis (self-reported)	1.3	1.7	4.5	-0.1	-0.8	-2.1
Medication: Aspirin	0.6	0.8	1.1	-0.4	-1.0	-1.0
Medication: Gliclazide	0.4	0.5	0.8	-0.9	0.1	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.7	1.1	0.7	1.1	-0.6
Smoking status: Current	0.2	0.4	0.6	0.3	-0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.2	-0.7	-0.8	-1.1
Whole body water mass	0.7	3.9	10.6	0.8	3.3	0.7
Leg predicted mass (right)	0.5	2.4	7.0	0.5	2.7	-0.1
Arm fat mass (left)	0.8	3.3	7.5	-0.3	1.5	-2.7
Number of self-reported non-cancer illnesses	1.9	3.3	4.8	-2.2	-0.7	-2.2
Average weekly champagne plus white wine intake	2.4	3.3	5.8	-2.4	-1.2	-1.7
Miserableness	0.6	1.0	2.7	-1.6	-0.1	-0.5
Guilty feelings	0.4	0.6	1.6	0.2	-1.3	-0.4
Wears glasses or contact lenses	1.0	1.1	2.1	-1.4	-0.9	-0.7
Ever taken oral contraceptive pill	0.5	0.6	1.2	0.7	0.4	1.1
Hearing aid user	0.1	0.1	0.2	0.2	-0.4	0.1
Mother’s age at death	1.6	2.0	4.3	1.1	2.1	0.6
Financial situation satisfaction	1.0	1.3	1.7	0.8	1.2	1.3
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.1	1.8	0.6	0.6
Commuting to job workplace: Public transport	0.3	0.3	0.9	0.9	0.1	0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	0.3	0.0
Medication: Blood pressure	0.8	1.6	2.8	-1.3	-0.2	-1.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.5	1.2	0.2	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.9	-0.1	-1.0	-0.2
High cholesterol (Self-reported)	0.2	0.4	0.8	-0.4	-0.4	-0.9
Medication: Bendroflumethiazide	0.6	0.9	2.3	-0.4	-1.5	-0.5
Medication: Paracetamol	0.1	0.1	0.3	-0.0	0.1	-0.6
Medication: Lisinopril	1.7	2.1	4.1	-1.5	0.4	-2.0
Medication: Atorvastatin	2.0	2.4	2.7	-1.6	-1.7	-1.4
Illnesses of father: High blood pressure	0.4	0.6	1.1	1.1	0.0	0.7
Alcohol drinker status: Never	0.2	0.3	0.5	-0.4	-0.7	-0.4
Ever smoked	0.8	1.4	2.9	0.8	1.7	0.8
Basal metabolic rate	0.7	3.9	11.0	0.8	3.3	0.3
Leg fat percentage (left)	0.9	3.2	7.6	-0.6	1.3	-2.8
Arm fat-free mass (left)	0.9	4.6	11.7	1.0	3.4	1.1
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	0.7	-0.1
Average weekly beer plus cider intake	1.1	1.6	2.7	-1.2	-1.7	-0.8
Irritability	2.2	3.6	5.9	-1.9	-2.4	-1.1
Risk taking	0.5	0.7	2.1	-1.4	-0.2	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	-0.4	-0.4	-0.4
Fractured/broken bones in last 5 years	0.6	0.7	2.1	-0.2	0.1	1.4
Age started oral contraceptive pill	0.3	0.4	0.7	-0.8	-0.5	-0.4
Diastolic blood pressure, automated reading	1.1	3.5	10.3	-0.2	-0.0	-3.2
Ever depressed for a whole week	0.4	0.5	0.8	-0.9	0.3	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.9	0.6	-0.1	1.0
Commuting to job workplace: Cycle	3.3	4.0	7.1	1.0	2.0	2.7
Myopia	3.2	4.7	5.4	1.8	2.3	2.3
Vascular/heart problems diagnosed by doctor	2.7	7.4	11.4	3.4	2.1	2.5
Cholesterol lowering medication	0.8	1.2	3.4	0.2	0.2	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	3.7	-1.9	0.1	-1.8
Pain experienced in last month	1.9	3.2	4.8	2.2	1.6	1.4
Supplements: Calcium	0.1	0.1	0.2	0.2	-0.1	-0.4
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	1.4	0.2	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	-0.4	-0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.7	-0.0	1.6	0.4
Heart disease (siblings)	0.8	1.0	2.9	0.1	-0.4	1.7
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.3	-0.8	-0.1
Pack years of smoking	2.5	3.7	5.8	-1.6	-2.4	-1.6
Impedance of whole body	0.5	2.4	4.9	1.2	-0.9	2.2
Leg fat mass (left)	0.7	2.7	4.2	-0.0	2.1	-1.9
Arm predicted mass (left)	0.8	4.3	10.6	1.3	3.3	0.8