Hub : Genes

SS18

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.2890 0.1210 0.00068 -0.009 NA 0.080 NA 0.027 8.8e-01 NA 0.00140 NA 0.0450
2 TCGA Breast Invasive Carcinoma 0.0313 0.0169 0.00059 0.023 0.01 0.017 NA 0.015 1.1e-05 0.0025 0.00015 NA 0.0003
3 TCGA Cervical Squamous Cell Carcinoma 0.0630 0.0370 0.00680 0.055 0.04 0.030 NA 0.029 1.1e-03 0.0046 0.01200 NA 0.0140

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.1 1.7 0.1 -1.3 -1.2
Bipolar Disorder or Schizophrenia 0.8 1.9 3.1 -1.8 -0.7 -1.4
Depressed Affect (Nagel 2018) 2.4 5.0 6.0 -2.2 -2.4 -2.1
Depression (Nagel 2018) 0.8 1.2 2.2 -1.2 -1.5 0.1
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.1 0.6 -0.4 1.0
Neuroticism (Nagel 2018) 1.9 4.4 5.2 -1.9 -2.3 -2.1
Schizophrenia (2018) 0.9 1.8 4.7 -2.2 0.1 -0.9
Schizophrenia vs Biploar Disorder 1.8 2.3 5.8 -2.4 0.8 0.8
Worry (Nagel 2018) 2.1 4.4 8.1 -2.0 -2.8 -1.1
Alzheimer’s Disease (in mother) 0.3 0.3 0.6 0.3 -0.6 -0.8
Alzheimer’s Disease (in father) 1.6 1.7 2.5 -1.2 -1.6 -1.1
Alzheimer’s Disease (including proxy) 0.7 1.0 1.7 -0.6 -1.3 -1.1
Crohns Disease (2017) 0.1 0.2 0.4 -0.0 -0.5 -0.6
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 0.1 -0.1 -0.2
Ulcerative Colitis (UC) 0.2 0.4 0.7 0.3 0.7 0.8
Major Depression (MDD) 0.1 0.2 0.5 0.1 0.7 -0.1
Reaction Time 0.4 0.7 1.4 -1.2 0.8 -0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.1 1.9 0.8 -0.9 1.4
Breast Cancer 0.9 2.1 5.4 -0.8 -2.3 0.6
Ovarian Cancer 0.4 0.6 1.3 -1.1 -0.6 -0.1
Prostate Cancer 1.5 2.1 4.4 1.2 0.6 2.1
Age at First Birth 1.0 1.5 4.1 -2.0 -0.6 0.1
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.3 0.0 0.4
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 -1.2 -0.2 -0.8
Coronary Artery Disease (CAD) 2.9 3.5 6.3 -1.4 -2.5 -1.5
Crohns Disease (2012) 0.4 0.6 1.6 -0.4 -1.3 0.2
Mean Putamen Volume 0.0 0.0 0.1 -0.1 0.0 -0.3
Fasting Glucose 1.3 1.6 4.1 0.6 -0.5 -2.0
HbA1C 0.6 0.7 1.2 1.1 0.8 -0.4
HDL Cholesterol 0.2 0.4 0.8 -0.9 -0.4 -0.5
LDL Cholesterol 0.7 1.2 3.5 -1.9 -0.1 0.1
Lupus 0.2 0.3 0.6 0.7 -0.4 0.3
Neuroticism (2016) 0.2 0.4 0.9 0.4 0.9 0.2
Primary Biliary Cirrhosis 0.3 0.5 1.1 -0.0 1.1 0.6
Rheumatoid Arthritis 0.8 1.1 1.5 1.2 1.2 0.6
Schizophrenia (2014) 0.5 1.0 2.0 -1.4 0.1 -1.0
Triglycerides 0.5 0.8 2.3 -0.1 -1.5 -0.0
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.0 -0.4 -0.8 -1.4
Ulcerative Colitis 0.5 0.7 1.2 -0.8 -1.1 -0.5
Blood Eosinophil Count 0.1 0.9 2.4 -0.3 0.4 1.5
Blood Platelet Count 0.4 4.6 11.7 -0.7 -3.4 -1.2
Blood Red Count 1.5 14.5 23.9 4.0 4.9 2.0
Blood White Count 0.9 7.0 16.1 -0.9 -4.0 -2.0
Heel T-Score 0.1 0.9 2.2 -0.4 1.5 -0.5
BMI 0.9 5.4 11.5 -1.0 1.9 -3.4
Height 2.2 41.8 61.0 3.6 7.2 7.8
Waist Hip Ratio (WHR) 1.1 5.1 5.4 2.3 2.2 2.3
Systolic Blood Pressure 0.5 2.6 6.1 0.2 -1.3 -2.5
Smoking Status 0.5 1.3 2.0 1.2 1.4 0.6
Allergy or Eczema 0.6 1.7 3.1 -0.7 -1.8 -1.2
Cardiovascular Disease 0.4 1.4 1.7 -1.3 -1.3 -0.9
Hypothyroidism (self reported) 3.6 8.2 23.0 1.0 4.8 0.8
Respiratory disease 0.8 1.7 4.4 0.9 -0.2 -2.1
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.5 0.3 -1.2 -1.6
Lung FEV1/FVC ratio 0.3 1.5 3.7 -0.3 1.9 0.9
Lung FVC 0.2 1.0 1.5 1.2 -1.0 -0.7
Neuroticism 3.8 9.1 14.0 -2.6 -3.7 -2.6
Chronotype (morning person) 0.8 1.8 3.1 -1.4 -1.8 -0.4
Hair Pigment 0.0 1.3 2.2 -0.0 -1.3 -1.5
Tanning 0.3 3.8 5.7 -1.5 -2.4 -1.9
Hand grip strength (left) 0.1 0.4 1.1 1.1 0.1 0.2
Number of treatments/medications taken 0.6 1.0 1.8 -1.4 -0.9 -0.7
Average weekly spirits intake 1.0 1.2 2.9 -0.4 -1.7 -0.7
Sensitivity / hurt feelings 0.7 1.2 2.9 0.5 -0.6 -1.7
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.8 -1.3 -1.3 -0.4
Hearing difficulty/problems: Yes 0.1 0.2 0.2 -0.4 0.4 0.3
Relative age of first facial hair 0.3 0.6 1.1 1.1 0.6 -0.7
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.6 0.1 1.3 -1.2
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.7 -0.6 -0.8 0.7
Ever had hysterectomy (womb removed) 0.4 0.5 1.1 -0.3 -0.6 -1.0
Systolic blood pressure, automated reading 1.9 5.4 14.4 -0.7 -1.2 -3.8
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 1.7 0.7 -0.8 -1.3
Angina 1.2 1.6 3.4 -0.6 -1.0 -1.9
Medication for hormone replacement therapy 0.7 0.8 1.5 -1.2 -0.9 -0.1
Vitamin and mineral supplements 0.1 0.1 0.2 0.2 0.4 0.4
Supplements: Zinc 0.6 0.6 1.7 0.1 -0.3 1.3
Medication: Co-codamol 0.8 0.9 1.4 -1.2 -0.8 -0.9
Medication: Metformin 0.4 0.6 1.2 0.5 1.1 -0.6
Diabetes (father) 0.9 1.1 1.7 -1.3 -1.3 0.2
Diabetes (mother) 0.2 0.2 0.4 0.7 0.2 -0.4
Severe depression (siblings) 2.2 2.4 2.7 1.6 1.4 1.6
Pack years adult smoking proportion 2.0 3.1 5.4 -1.3 -2.3 -1.5
Impedance of leg (right) 0.6 3.0 7.8 1.0 -0.3 2.8
Leg fat-free mass (left) 0.4 2.3 6.6 0.3 2.6 -0.4
Trunk fat percentage 0.4 1.7 4.1 -0.0 0.9 -2.0
Hand grip strength (right) 0.5 1.4 2.6 1.0 0.9 1.6
Townsend deprivation index at recruitment 1.3 1.8 2.9 1.7 0.4 -1.6
Current tobacco smoking 0.3 0.5 0.8 -0.0 -0.9 0.9
Average weekly fortified wine intake 0.8 0.9 1.9 0.6 1.4 -0.7
Maternal smoking around birth 1.0 1.4 1.8 -1.4 -0.8 -1.3
Fed-up feelings 3.1 5.7 5.9 -2.4 -2.4 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.4 -0.4 -1.2 -0.7
Relative age voice broke 1.0 1.5 2.1 1.4 1.2 -0.9
Taking other prescription medications 0.3 0.4 0.7 -0.8 0.7 -0.2
Age when periods started (menarche) 0.2 0.6 0.9 -0.3 0.9 0.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.1 -0.2 -1.0 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 4.1 2.0 1.1 0.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.3 -0.3 1.1 0.1
Qualifications: CSEs or equivalent 2.3 3.0 4.8 -0.8 -2.2 -1.9
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.2 0.0 -0.4
High blood pressure 2.4 6.6 7.7 -2.8 -2.3 -2.6
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.8 -0.8 -1.4 0.2
Multivitamins +/- minerals 0.2 0.2 0.6 -0.3 -0.3 -0.8
Stomach or abdominal pain in last month 0.3 0.4 0.9 -1.0 -0.3 -0.2
Supplements: Glucosamine 0.2 0.3 0.4 -0.7 -0.6 0.3
Diverticular disease/diverticulitis (self-reported) 3.8 4.5 11.8 -3.4 -1.0 -0.8
Medication: Atenolol 0.8 1.0 2.5 -0.3 0.7 -1.6
Medication: Levothyroxine sodium 3.0 5.1 13.8 0.1 3.7 1.3
Sitting height 0.5 3.3 5.5 1.7 2.3 1.2
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 0.1 -0.4 -0.5
High blood pressure (mother) 0.7 0.9 1.6 0.0 -1.3 -1.1
Body mass index (BMI) 1.1 4.8 12.6 -1.0 0.9 -3.5
Impedance of leg (left) 0.9 4.3 11.0 1.4 -0.1 3.3
Leg predicted mass (left) 0.4 2.3 6.7 0.2 2.6 -0.4
Trunk fat mass 0.5 2.3 3.6 0.4 1.9 -1.7
Waist circumference 1.0 3.6 7.2 1.1 2.7 -1.5
Number of incorrect matches in round 0.4 0.7 1.3 -0.3 -1.1 -0.9
Past tobacco smoking 1.4 2.5 4.5 -1.3 -2.1 -1.1
Alcohol usually taken with meals 0.3 0.5 0.9 -0.9 -0.0 -0.7
Nervous feelings 1.4 2.7 3.5 -1.0 -1.8 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.3 -1.1 -0.7 -0.4
Hearing difficulty/problems with background noise 0.0 0.0 0.1 0.2 -0.1 -0.1
Hair/balding pattern: Pattern 2 0.6 0.7 2.0 0.1 -1.4 -0.4
Had menopause 0.9 1.1 2.8 -0.1 -1.7 -0.7
Had other major operations 0.1 0.2 0.4 -0.1 0.3 -0.6
Forced vital capacity (FVC) 0.7 2.7 5.1 2.3 1.5 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.1 1.4 1.1 0.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.4 -1.2 0.6 0.0
Qualifications: None of the above 0.7 1.6 1.8 -1.1 -1.3 -1.3
Financial difficulties in last 2 years 0.3 0.4 0.8 -0.9 0.5 0.1
Mouth/teeth dental problems 1.2 1.8 2.9 0.4 1.7 1.5
Heart attack 0.3 0.4 0.7 -0.7 -0.8 0.2
Allergy 0.3 0.7 1.0 0.2 1.0 1.0
Pain all over the body in last month 2.5 2.7 3.2 -1.8 -1.8 -1.3
Diabetes (self-reported) 1.4 2.2 4.8 -0.4 -1.3 -2.2
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 5.9 -0.5 -2.4 0.6
Medication: Ramipril 0.4 0.5 0.7 0.8 0.3 -0.9
Medication: Simvastatin 0.1 0.1 0.3 0.4 -0.1 -0.5
Fluid intelligence score 0.3 0.6 1.2 1.1 -0.8 0.3
Illnesses of siblings 0.3 0.4 0.6 0.6 0.3 -0.8
Neuroticism score 2.1 4.5 6.4 -2.0 -2.5 -1.7
Weight 0.6 3.2 7.6 0.3 2.8 -1.3
Impedance of arm (right) 0.1 0.5 1.1 0.3 -0.6 1.0
Arm fat percentage (right) 1.1 4.2 10.9 -0.5 1.1 -3.3
Trunk fat-free mass 0.9 5.1 12.5 1.0 3.5 1.3
Hip circumference 0.7 3.0 6.6 -0.1 1.5 -2.6
Time employed in main current job 0.8 1.0 2.0 0.8 0.5 1.4
Alcohol intake versus 10 years previously 0.6 1.0 1.6 -0.3 1.1 1.3
Father’s age at death 0.7 0.9 2.3 0.1 1.5 0.7
Worrier / anxious feelings 0.5 1.0 2.9 -0.3 -1.7 0.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 3.2 -1.2 -0.8 -1.8
Falls in the last year 1.1 1.5 3.5 -0.3 -1.0 1.9
Hair/balding pattern: Pattern 3 0.1 0.2 0.3 -0.3 0.6 -0.4
Number of live births 0.5 0.7 1.7 -0.1 -0.6 1.3
Forced expiratory volume in 1-second (FEV1) 0.9 3.2 4.4 1.9 2.1 1.2
Pulse rate 1.2 2.0 3.1 1.7 -0.2 1.8
Happiness 1.0 1.2 1.9 -1.4 -0.3 1.2
Noisy workplace 1.0 1.2 3.0 -1.7 -0.3 0.7
Qualifications: A levels/AS levels or equivalent 0.2 0.5 0.8 0.9 0.7 -0.5
Serious illness, injury or assault of a close relative in last 2 years 4.8 5.5 10.2 2.2 1.1 3.2
Mouth/teeth dental problems: Dentures 0.2 0.3 0.7 0.2 -0.6 -0.8
Asthma 1.0 1.9 4.9 -0.1 -1.0 -2.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 1.1 1.0 0.9 0.7
Medication: Cholesterol lowering 2.2 3.4 7.6 -0.6 -2.8 -1.6
Depression (self-reported) 0.5 0.6 0.8 0.9 0.9 -0.4
Medication: Lansoprazole 1.1 1.2 2.9 -1.7 -0.6 -0.6
Prospective memory result 0.6 0.8 0.9 1.0 -0.7 -0.9
Lung cancer (father) 1.7 1.9 3.9 -1.2 -2.0 -0.6
Illnesses of mother 2.5 3.1 6.7 0.2 2.6 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.0 1.7 1.3 1.2
Pulse wave Arterial Stiffness index 2.2 2.6 4.3 1.1 2.1 1.5
Impedance of arm (left) 0.2 0.7 1.6 0.1 -1.3 0.8
Arm fat mass (right) 0.8 3.4 6.8 -0.2 1.8 -2.6
Trunk predicted mass 0.9 5.3 13.0 1.0 3.6 1.3
Standing height 1.7 16.5 22.0 3.1 4.2 4.7
Length of working week for main job 2.0 2.2 6.6 -0.0 -2.6 -0.0
Exposure to tobacco smoke at home 0.9 1.0 1.7 -1.3 0.6 -1.0
Breastfed as a baby 1.1 1.4 2.0 1.3 1.4 0.6
Tense / ‘highly strung’ 3.6 6.0 9.3 -2.2 -3.0 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 2.3 -1.5 -1.2 -1.1
Hair/balding pattern: Pattern 4 1.6 3.8 7.9 1.7 2.8 0.9
Birth weight of first child 0.1 0.2 0.2 -0.5 0.5 0.1
Peak expiratory flow (PEF) 1.8 4.1 6.7 1.9 2.6 1.4
Pulse wave reflection index 0.3 0.4 1.1 -0.3 1.0 0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 -0.5 -0.7 0.0
Loud music exposure frequency 1.4 1.5 3.6 0.1 -0.9 -1.9
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 2.4 0.3 1.6 -0.3
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.3 -1.8 -1.3 -0.7
Blood clot in the leg (DVT) 0.8 1.0 2.8 -0.3 1.7 0.3
Medication: Paracetamol 0.5 0.7 1.5 -0.1 -0.8 -1.2
Headache pain in last month 0.9 1.6 3.3 0.8 -0.9 -1.8
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 3.9 0.3 2.0 1.5
Glaucoma (self-reported) 0.2 0.3 0.6 -0.4 0.8 -0.2
Gout (self-reported) 1.9 2.7 5.4 -1.6 -2.3 -0.4
Hypothyroidism/myxoedema (self-reported) 3.5 6.8 19.4 0.7 4.4 0.7
Medication: Amlodipine 0.9 1.2 2.9 -0.4 -1.7 0.7
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 0.5 -0.4 -0.7
Birth weight 1.3 2.7 4.3 1.1 1.7 2.1
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.6 -1.9 -0.3 -0.6
High blood pressure (siblings) 0.3 0.5 1.0 -0.4 -1.0 -0.5
Forced vital capacity (FVC), Best measure 0.6 2.1 3.8 2.0 1.2 1.0
Body fat percentage 0.7 2.8 7.3 -0.1 1.0 -2.7
Leg fat percentage (right) 1.1 4.1 10.6 -0.9 1.0 -3.2
Arm fat-free mass (right) 0.6 3.2 8.4 0.8 2.9 0.7
Exposure to tobacco smoke outside home 1.0 1.3 3.0 1.7 0.7 -0.8
Comparative body size at age 10 0.7 2.0 4.5 -0.7 1.0 -2.1
Number of full brothers 0.2 0.3 0.8 -0.1 -0.2 0.9
Worry too long after embarrassment 0.1 0.2 0.4 0.6 0.3 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.7 -1.3 -0.3 0.7
Wheeze or whistling in the chest in last year 0.7 1.2 2.7 -1.0 -0.1 -1.6
Number of children fathered 1.7 2.0 4.9 -2.2 -0.8 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 1.3 -1.1 -1.1 -0.4
Age at first live birth 0.4 0.6 1.2 1.1 0.7 0.5
Pulse wave peak to peak time 1.7 2.0 3.6 -0.8 -1.9 -1.4
Health satisfaction 0.1 0.1 0.2 -0.1 0.4 -0.3
Shortness of breath walking on level ground 1.0 1.1 2.0 -1.1 -0.5 -1.4
Qualifications: College or University degree 1.2 3.9 5.8 2.4 2.1 1.2
Eye problems/disorders: None of the above 1.4 1.6 3.2 0.8 1.1 1.8
Mouth/teeth dental problems: Loose teeth 1.1 1.3 1.9 -1.4 0.3 -1.3
Emphysema/chronic bronchitis 0.9 1.0 2.3 1.5 0.7 -0.3
Medication for pain relief, constipation, heartburn 0.8 1.3 2.5 0.5 1.1 1.6
Neck or shoulder pain in last month 0.3 0.4 0.9 -1.0 0.5 0.1
Medication: Blood pressure 1.2 2.2 3.3 -0.6 -1.7 -1.8
Angina (self-reported) 1.4 1.8 3.7 -0.7 -1.1 -1.9
Migraine (self-reported) 2.0 2.5 3.5 -1.9 -1.6 -1.3
Medication: Ibuprofen 0.5 0.6 0.8 0.8 0.6 0.9
Medication: Allopurinol 1.3 1.8 3.9 -1.1 -2.0 0.4
Medication: Omeprazole 0.7 0.9 1.7 -0.9 0.3 -1.3
Medication: Seretide 50 evohaler 0.5 0.6 1.2 0.1 1.1 -0.7
Mean time to correctly identify matches 0.4 0.8 1.1 -1.1 0.9 -0.6
Heart disease (mother) 0.1 0.2 0.3 -0.3 -0.6 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 2.5 -0.8 -1.6 -1.2
Whole body fat mass 0.6 2.6 4.5 0.1 1.8 -2.1
Leg fat mass (right) 0.8 2.9 5.2 -0.3 1.9 -2.3
Arm predicted mass (right) 0.6 3.2 7.4 1.2 2.7 0.8
Pulse rate, automated reading 0.6 2.1 5.0 2.2 -0.2 1.1
Alcohol intake frequency. 0.2 0.4 0.7 0.6 -0.8 -0.0
Comparative height size at age 10 1.1 6.1 10.7 0.3 2.7 3.3
Number of full sisters 2.3 2.7 5.7 2.4 1.2 1.1
Suffer from ‘nerves’ 1.4 2.2 3.3 -1.3 -1.3 -1.8
Overall health rating 2.8 6.0 7.2 -2.1 -2.5 -2.7
Chest pain or discomfort 0.7 1.1 1.5 1.1 1.2 0.6
Had major operations 0.2 0.2 0.5 -0.1 -0.7 -0.2
Age at last live birth 0.8 1.2 3.1 0.5 1.8 0.4
Family relationship satisfaction 0.3 0.4 1.1 -0.2 -0.2 1.0
Leg pain on walking 0.7 0.8 1.1 -0.7 -1.0 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.9 -0.6 0.5 -1.0
Commuting to job workplace: Car/motor vehicle 1.5 1.7 4.3 -2.1 -0.6 0.6
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 2.9 1.7 -0.5 -1.0
Medication: Aspirin 0.3 0.3 0.5 -0.4 -0.7 -0.6
Supplements: Vitamin C 0.4 0.5 0.9 0.6 -1.0 -0.4
Knee pain experienced in last month 0.4 0.6 1.7 -1.3 0.3 -0.0
Hypertension (Self-reported) 1.9 5.1 6.3 -2.3 -2.0 -2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.5 -0.7 0.1 -0.1
Illnesses of father: Heart disease 2.1 2.9 4.4 -2.1 -2.1 -0.4
Illnesses of siblings: Diabetes 0.4 0.5 0.9 -0.8 0.9 0.2
Smoking status: Previous 1.6 2.5 6.0 1.0 2.4 0.7
Forced expiratory volume in 1-second (FEV1), predicted 2.8 5.8 10.7 1.8 1.9 3.3
Whole body fat-free mass 0.7 3.8 10.6 0.7 3.3 0.6
Leg fat-free mass (right) 0.4 2.4 6.9 0.4 2.6 -0.1
Arm fat percentage (left) 1.1 4.6 12.7 -0.7 0.6 -3.6
Average weekly red wine intake 5.9 8.7 12.9 3.6 3.2 1.7
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.9 2.2 0.5 -0.6
Mood swings 2.4 4.3 7.2 -2.7 -2.0 -1.3
Loneliness, isolation 3.0 4.2 7.8 -1.6 -1.4 -2.8
Long-standing illness, disability or infirmity 0.1 0.1 0.2 -0.3 0.5 0.1
Ever had bowel cancer screening 4.3 5.1 8.2 -2.9 -2.6 -0.4
Diabetes diagnosed by doctor 1.6 2.6 5.5 -0.8 -1.3 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.3 -0.8 0.2 1.1
Friendships satisfaction 0.8 1.0 2.0 -0.8 -1.4 0.6
Qualifications: nursing, teaching 1.6 2.5 4.5 0.8 1.5 2.1
Commuting to job workplace: Walk 3.3 3.6 9.9 3.2 0.9 -0.2
Eye problems/disorders: Cataract 1.2 1.4 2.9 -0.5 -1.7 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.8 0.5 -1.7 1.1
Medication for cholesterol 0.4 0.7 1.0 1.0 0.6 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.5 -0.3 -0.6 -0.7
Back pain experienced in last month 0.3 0.4 0.8 -0.5 -0.9 -0.5
Mineral and other dietary supplements 0.2 0.3 0.9 -0.1 0.2 -1.0
Breast cancer (self-reported) 1.1 1.3 3.2 1.8 -0.4 0.7
Asthma (self-reported) 0.9 1.8 4.5 -0.1 -0.9 -2.1
Osteoporosis (self-reported) 0.8 1.0 2.3 -1.5 -0.8 -0.0
Osteoarthritis (self-reported) 1.3 1.7 4.5 -0.1 -0.8 -2.1
Medication: Aspirin 0.6 0.8 1.1 -0.4 -1.0 -1.0
Medication: Gliclazide 0.4 0.5 0.8 -0.9 0.1 -0.8
Illnesses of father: None of the above (group 1) 0.5 0.7 1.1 0.7 1.1 -0.6
Smoking status: Current 0.2 0.4 0.6 0.3 -0.8 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.2 -0.7 -0.8 -1.1
Whole body water mass 0.7 3.9 10.6 0.8 3.3 0.7
Leg predicted mass (right) 0.5 2.4 7.0 0.5 2.7 -0.1
Arm fat mass (left) 0.8 3.3 7.5 -0.3 1.5 -2.7
Number of self-reported non-cancer illnesses 1.9 3.3 4.8 -2.2 -0.7 -2.2
Average weekly champagne plus white wine intake 2.4 3.3 5.8 -2.4 -1.2 -1.7
Miserableness 0.6 1.0 2.7 -1.6 -0.1 -0.5
Guilty feelings 0.4 0.6 1.6 0.2 -1.3 -0.4
Wears glasses or contact lenses 1.0 1.1 2.1 -1.4 -0.9 -0.7
Ever taken oral contraceptive pill 0.5 0.6 1.2 0.7 0.4 1.1
Hearing aid user 0.1 0.1 0.2 0.2 -0.4 0.1
Mother’s age at death 1.6 2.0 4.3 1.1 2.1 0.6
Financial situation satisfaction 1.0 1.3 1.7 0.8 1.2 1.3
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.1 1.8 0.6 0.6
Commuting to job workplace: Public transport 0.3 0.3 0.9 0.9 0.1 0.2
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 -0.7 0.3 0.0
Medication: Blood pressure 0.8 1.6 2.8 -1.3 -0.2 -1.7
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.5 1.2 0.2 -0.9
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.9 -0.1 -1.0 -0.2
High cholesterol (Self-reported) 0.2 0.4 0.8 -0.4 -0.4 -0.9
Medication: Bendroflumethiazide 0.6 0.9 2.3 -0.4 -1.5 -0.5
Medication: Paracetamol 0.1 0.1 0.3 -0.0 0.1 -0.6
Medication: Lisinopril 1.7 2.1 4.1 -1.5 0.4 -2.0
Medication: Atorvastatin 2.0 2.4 2.7 -1.6 -1.7 -1.4
Illnesses of father: High blood pressure 0.4 0.6 1.1 1.1 0.0 0.7
Alcohol drinker status: Never 0.2 0.3 0.5 -0.4 -0.7 -0.4
Ever smoked 0.8 1.4 2.9 0.8 1.7 0.8
Basal metabolic rate 0.7 3.9 11.0 0.8 3.3 0.3
Leg fat percentage (left) 0.9 3.2 7.6 -0.6 1.3 -2.8
Arm fat-free mass (left) 0.9 4.6 11.7 1.0 3.4 1.1
Number of operations (self-reported) 0.2 0.3 0.6 -0.8 0.7 -0.1
Average weekly beer plus cider intake 1.1 1.6 2.7 -1.2 -1.7 -0.8
Irritability 2.2 3.6 5.9 -1.9 -2.4 -1.1
Risk taking 0.5 0.7 2.1 -1.4 -0.2 0.1
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.2 -0.4 -0.4 -0.4
Fractured/broken bones in last 5 years 0.6 0.7 2.1 -0.2 0.1 1.4
Age started oral contraceptive pill 0.3 0.4 0.7 -0.8 -0.5 -0.4
Diastolic blood pressure, automated reading 1.1 3.5 10.3 -0.2 -0.0 -3.2
Ever depressed for a whole week 0.4 0.5 0.8 -0.9 0.3 -0.8
Unable to work because of sickness or disability 0.3 0.4 0.9 0.6 -0.1 1.0
Commuting to job workplace: Cycle 3.3 4.0 7.1 1.0 2.0 2.7
Myopia 3.2 4.7 5.4 1.8 2.3 2.3
Vascular/heart problems diagnosed by doctor 2.7 7.4 11.4 3.4 2.1 2.5
Cholesterol lowering medication 0.8 1.2 3.4 0.2 0.2 -1.8
Medication: Omeprazole (e.g. Zanprol) 1.9 2.4 3.7 -1.9 0.1 -1.8
Pain experienced in last month 1.9 3.2 4.8 2.2 1.6 1.4
Supplements: Calcium 0.1 0.1 0.2 0.2 -0.1 -0.4
Basal cell carcinoma (self-reported) 0.6 0.7 1.9 1.4 0.2 0.3
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.3 -0.4 -0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 2.7 -0.0 1.6 0.4
Heart disease (siblings) 0.8 1.0 2.9 0.1 -0.4 1.7
Alcohol drinker status: Previous 0.2 0.2 0.6 -0.3 -0.8 -0.1
Pack years of smoking 2.5 3.7 5.8 -1.6 -2.4 -1.6
Impedance of whole body 0.5 2.4 4.9 1.2 -0.9 2.2
Leg fat mass (left) 0.7 2.7 4.2 -0.0 2.1 -1.9
Arm predicted mass (left) 0.8 4.3 10.6 1.3 3.3 0.8