Hub : Genes

SSBP3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.230 0.076 0.0054 0.149 NA 0.103 NA 0.110 3.3e-07 NA 2.3e-05 NA 1.3e-05
2 GTEx Liver 0.469 0.131 0.0023 0.054 NA 0.248 NA 0.104 1.3e-02 NA 1.4e-07 NA 7.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.2 1.9 3.2 -0.8 -1.8
Bipolar Disorder or Schizophrenia 0.2 0.4 0.6 -0.5 -0.7
Depressed Affect (Nagel 2018) 1.0 2.2 2.8 1.7 1.3
Depression (Nagel 2018) 2.4 3.5 6.8 0.5 2.6
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.2 0.3 -1.5
Neuroticism (Nagel 2018) 3.1 7.3 10.0 3.2 2.1
Schizophrenia (2018) 0.0 0.1 0.1 -0.0 0.3
Schizophrenia vs Biploar Disorder 0.4 0.5 1.0 0.2 1.0
Worry (Nagel 2018) 3.7 7.8 12.4 3.5 1.8
Alzheimer’s Disease (in mother) 0.7 0.8 1.6 -0.1 -1.3
Alzheimer’s Disease (in father) 1.6 1.8 2.8 -0.9 1.7
Alzheimer’s Disease (including proxy) 1.0 1.5 2.6 -1.6 -0.6
Crohns Disease (2017) 1.5 3.3 5.7 1.0 -2.4
Irritable Bowel Disease (IBD) 0.2 0.4 0.6 0.5 -0.8
Ulcerative Colitis (UC) 0.0 0.0 0.1 -0.3 0.0
Major Depression (MDD) 0.3 0.4 0.7 -0.2 -0.9
Reaction Time 1.1 2.1 4.1 -2.0 -0.1
Verbal and Numeric Reasoning (VNR) 0.0 0.0 0.0 0.0 -0.0
Breast Cancer 0.6 1.4 2.8 -0.3 -1.7
Ovarian Cancer 0.5 0.6 1.3 0.1 -1.1
Prostate Cancer 0.2 0.3 0.4 -0.5 0.6
Age at First Birth 0.7 1.0 1.4 -1.2 0.8
Bipolar Disorder (2011) 0.0 0.0 0.1 -0.2 0.0
Body Mass Index (BMI) (2010) 4.6 6.3 12.5 -3.5 -0.3
Coronary Artery Disease (CAD) 0.9 1.1 1.7 1.3 0.7
Crohns Disease (2012) 1.0 1.6 3.2 0.2 -1.8
Mean Putamen Volume 1.1 1.3 2.5 -1.6 0.3
Fasting Glucose 0.7 0.9 1.6 -1.3 -0.4
HbA1C 3.8 4.3 7.6 2.8 -0.9
HDL Cholesterol 1.2 2.0 3.3 1.8 0.9
LDL Cholesterol 0.6 0.9 1.8 -1.4 -0.1
Lupus 0.6 0.9 1.8 -0.2 1.3
Neuroticism (2016) 0.9 1.3 2.5 1.6 0.2
Primary Biliary Cirrhosis 0.3 0.5 0.8 0.4 -0.9
Rheumatoid Arthritis 0.1 0.2 0.4 0.6 -0.2
Schizophrenia (2014) 0.0 0.1 0.1 -0.2 0.3
Triglycerides 2.4 3.9 7.0 -2.6 -1.0
Type 2 Diabetes (T2D) (2012) 0.0 0.1 0.1 -0.2 0.2
Ulcerative Colitis 0.1 0.1 0.2 0.1 0.4
Blood Eosinophil Count 0.5 4.2 4.9 -2.2 -1.9
Blood Platelet Count 0.2 2.4 3.4 1.2 -1.8
Blood Red Count 0.1 1.2 1.5 -1.2 -1.0
Blood White Count 0.7 5.0 5.3 2.2 -2.3
Heel T-Score 0.3 2.1 2.7 -1.6 1.2
BMI 2.2 12.6 25.0 -5.0 -0.5
Height 0.2 4.8 5.9 -2.4 1.9
Waist Hip Ratio (WHR) 0.7 3.3 6.4 -2.5 0.6
Systolic Blood Pressure 0.4 1.8 3.1 0.7 -1.8
Smoking Status 0.0 0.1 0.2 0.2 0.4
Allergy or Eczema 0.6 1.5 2.2 1.5 -0.9
Cardiovascular Disease 0.0 0.1 0.2 0.1 -0.5
Hypothyroidism (self reported) 0.4 0.9 1.6 -1.3 0.5
Respiratory disease 0.0 0.0 0.0 0.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.2 -1.1 -0.6
Lung FEV1/FVC ratio 0.1 0.5 0.9 -0.9 0.3
Lung FVC 0.1 0.7 1.4 1.2 -0.0
Neuroticism 1.5 3.6 5.3 2.3 1.4
Chronotype (morning person) 0.4 0.9 1.2 -0.7 -1.1
Hair Pigment 0.0 0.2 0.3 0.6 0.3
Tanning 0.3 3.7 7.3 2.7 0.5
Hand grip strength (left) 0.3 0.7 0.8 0.7 0.9
Number of treatments/medications taken 0.2 0.3 0.5 0.7 -0.4
Average weekly spirits intake 0.2 0.2 0.4 0.2 -0.6
Sensitivity / hurt feelings 0.9 1.5 2.0 1.4 0.9
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.3 -0.1 1.5
Hearing difficulty/problems: Yes 0.0 0.0 0.0 -0.2 0.1
Relative age of first facial hair 1.2 2.4 3.2 1.8 -1.3
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.8 -1.4 0.0
Ever used hormone-replacement therapy (HRT) 1.9 2.5 2.6 1.6 -1.5
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.0 0.5
Systolic blood pressure, automated reading 0.1 0.3 0.6 0.1 -0.8
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.1 0.0
Angina 0.6 0.8 1.2 1.1 -0.6
Medication for hormone replacement therapy 1.0 1.1 2.0 1.4 -0.4
Vitamin and mineral supplements 0.0 0.1 0.1 0.1 0.3
Supplements: Zinc 3.6 3.9 7.5 -0.5 2.7
Medication: Co-codamol 0.6 0.7 0.9 -0.7 0.9
Medication: Metformin 1.4 1.9 3.7 -1.9 0.4
Diabetes (father) 3.0 3.8 7.3 2.7 -0.4
Diabetes (mother) 0.1 0.1 0.2 0.1 -0.4
Severe depression (siblings) 0.8 0.9 1.5 0.6 -1.2
Pack years adult smoking proportion 1.6 2.4 4.2 -2.0 -0.8
Impedance of leg (right) 1.3 6.1 11.6 3.4 0.8
Leg fat-free mass (left) 1.9 10.3 20.4 -4.5 -0.4
Trunk fat percentage 1.3 5.4 9.7 -3.1 -1.0
Hand grip strength (right) 0.1 0.2 0.3 0.6 0.1
Townsend deprivation index at recruitment 2.5 3.5 5.3 1.3 -2.3
Current tobacco smoking 0.3 0.6 1.1 -1.1 -0.0
Average weekly fortified wine intake 2.3 2.7 3.7 -1.3 -1.9
Maternal smoking around birth 0.1 0.1 0.2 0.4 0.1
Fed-up feelings 0.5 0.8 1.5 1.2 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.1 -0.3 2.0
Relative age voice broke 1.3 2.0 3.6 1.9 -0.6
Taking other prescription medications 0.1 0.2 0.3 0.4 -0.5
Age when periods started (menarche) 3.7 9.0 17.5 4.2 -0.7
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.1 0.3 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.3 0.5 0.6
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.6 0.8 -0.7
Qualifications: CSEs or equivalent 0.9 1.2 1.5 1.2 -1.0
Serious illness, injury or assault to yourself 2.1 2.6 4.0 -2.0 -1.1
High blood pressure 0.4 1.1 2.0 -0.5 -1.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 0.7 0.8 -0.7
Multivitamins +/- minerals 0.5 0.6 0.8 -0.6 0.9
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.0 0.5
Supplements: Glucosamine 3.6 4.7 5.9 -2.4 1.8
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.4 -0.1 -1.2
Medication: Atenolol 2.0 2.5 3.1 1.8 1.3
Medication: Levothyroxine sodium 0.2 0.3 0.5 -0.7 -0.5
Sitting height 0.7 4.7 5.1 -2.2 2.1
Chronic bronchitis/emphysema (father) 0.7 0.9 1.5 0.5 -1.2
High blood pressure (mother) 0.6 0.9 1.6 -1.3 0.4
Body mass index (BMI) 1.8 7.6 14.7 -3.8 -0.7
Impedance of leg (left) 1.4 6.6 11.2 3.4 1.4
Leg predicted mass (left) 2.0 10.4 20.6 -4.5 -0.3
Trunk fat mass 1.5 6.6 12.8 -3.6 -0.6
Waist circumference 2.1 7.8 15.2 -3.9 -0.6
Number of incorrect matches in round 0.4 0.6 1.0 -0.5 1.0
Past tobacco smoking 0.7 1.4 1.8 -1.0 1.3
Alcohol usually taken with meals 0.7 1.2 1.8 -1.3 -0.8
Nervous feelings 1.6 3.0 4.5 2.1 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.3 -0.5 1.5
Hearing difficulty/problems with background noise 0.2 0.3 0.5 -0.7 -0.1
Hair/balding pattern: Pattern 2 0.8 1.0 1.9 -0.4 -1.4
Had menopause 0.3 0.3 0.5 0.3 -0.7
Had other major operations 0.0 0.0 0.0 0.1 -0.2
Forced vital capacity (FVC) 0.3 1.3 2.2 -0.6 1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.2 -0.3 0.4
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 1.3 1.1 1.1
Qualifications: None of the above 0.7 1.5 2.4 -1.6 -0.7
Financial difficulties in last 2 years 1.2 1.6 2.6 1.6 -0.7
Mouth/teeth dental problems 0.8 1.2 2.2 1.5 0.5
Heart attack 1.3 1.7 3.0 0.6 -1.7
Allergy 0.4 1.0 1.4 -1.2 0.8
Pain all over the body in last month 0.4 0.5 0.5 0.7 0.7
Diabetes (self-reported) 0.4 0.6 1.3 -1.1 -0.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.8 0.9 0.2
Medication: Ramipril 0.3 0.4 0.6 -0.3 0.8
Medication: Simvastatin 0.3 0.5 0.7 0.8 -0.5
Fluid intelligence score 0.4 0.8 1.5 -1.2 0.2
Illnesses of siblings 0.9 1.3 1.6 -1.3 1.0
Neuroticism score 1.6 3.3 5.4 2.3 1.0
Weight 2.2 10.8 21.5 -4.6 -0.2
Impedance of arm (right) 0.4 1.9 3.1 1.8 -0.8
Arm fat percentage (right) 1.5 5.8 10.7 -3.3 -1.0
Trunk fat-free mass 1.2 6.6 11.9 -3.5 1.1
Hip circumference 1.3 5.8 11.4 -3.4 -0.4
Time employed in main current job 1.2 1.4 2.0 -0.8 1.4
Alcohol intake versus 10 years previously 0.1 0.2 0.3 -0.6 -0.2
Father’s age at death 0.6 0.9 1.5 -0.4 1.2
Worrier / anxious feelings 1.9 3.6 6.8 2.6 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.0 0.5 1.4
Falls in the last year 1.5 2.0 4.0 -0.2 -2.0
Hair/balding pattern: Pattern 3 0.1 0.2 0.2 -0.4 0.5
Number of live births 0.2 0.2 0.4 0.7 -0.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 1.3 -0.9 1.2
Pulse rate 0.1 0.2 0.5 0.7 0.1
Happiness 0.7 0.8 1.4 1.2 0.5
Noisy workplace 4.1 5.0 9.6 3.1 0.7
Qualifications: A levels/AS levels or equivalent 1.5 3.3 6.4 -2.5 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.3 0.1 0.6
Mouth/teeth dental problems: Dentures 2.5 4.1 5.0 -1.8 -2.2
Asthma 0.2 0.3 0.5 0.7 0.4
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 2.4 -1.5 1.1
Medication: Cholesterol lowering 0.0 0.0 0.0 0.1 0.1
Depression (self-reported) 0.0 0.0 0.1 0.1 0.3
Medication: Lansoprazole 2.7 3.1 5.1 2.2 -1.1
Prospective memory result 0.5 0.6 1.2 0.1 -1.1
Lung cancer (father) 0.5 0.5 0.7 0.6 0.8
Illnesses of mother 1.0 1.3 2.5 -0.1 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 2.3 -1.5 0.8
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.6 -0.3
Impedance of arm (left) 0.5 2.4 4.6 2.1 -0.3
Arm fat mass (right) 2.1 8.7 17.2 -4.1 -0.5
Trunk predicted mass 1.1 6.4 11.4 -3.4 1.2
Standing height 0.4 3.6 5.8 -2.4 1.1
Length of working week for main job 0.7 0.8 1.0 -1.0 0.8
Exposure to tobacco smoke at home 0.6 0.7 0.8 -0.9 0.7
Breastfed as a baby 0.1 0.1 0.2 0.4 -0.0
Tense / ‘highly strung’ 1.1 1.9 2.0 1.3 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.8 1.7 -0.3
Hair/balding pattern: Pattern 4 0.7 1.6 2.5 -1.6 0.9
Birth weight of first child 0.4 0.8 1.6 -0.2 1.2
Peak expiratory flow (PEF) 0.5 1.1 2.1 -1.5 0.0
Pulse wave reflection index 0.0 0.0 0.1 0.0 -0.3
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.5 1.6 0.4
Loud music exposure frequency 1.0 1.1 1.8 1.3 0.7
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.0 1.0 -0.6
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.4 0.1 1.5
Blood clot in the leg (DVT) 0.3 0.3 0.4 0.5 -0.7
Medication: Paracetamol 1.9 3.1 5.7 2.4 0.7
Headache pain in last month 0.2 0.3 0.7 0.8 0.0
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.2 -0.5 -0.3
Glaucoma (self-reported) 2.2 2.5 4.0 2.0 1.0
Gout (self-reported) 0.3 0.5 1.0 -1.0 0.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 -1.1 0.3
Medication: Amlodipine 0.6 0.8 1.3 -1.2 -0.6
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.4 0.6 0.4
Birth weight 0.4 1.0 1.8 0.3 1.4
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.5 -0.3 -1.6
High blood pressure (siblings) 0.6 0.8 1.2 1.1 -0.7
Forced vital capacity (FVC), Best measure 0.5 1.7 1.8 -1.3 1.3
Body fat percentage 1.1 4.5 8.5 -2.9 -0.7
Leg fat percentage (right) 0.5 1.9 3.8 -2.0 -0.2
Arm fat-free mass (right) 1.6 8.1 15.7 -4.0 0.7
Exposure to tobacco smoke outside home 1.4 1.9 2.0 1.4 1.3
Comparative body size at age 10 6.1 16.9 28.0 -5.3 2.4
Number of full brothers 0.0 0.0 0.0 -0.2 -0.1
Worry too long after embarrassment 1.4 2.3 4.7 2.2 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.5 3.0 1.7 1.4
Wheeze or whistling in the chest in last year 0.4 0.7 1.1 1.0 -0.6
Number of children fathered 0.4 0.4 0.6 -0.8 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.6 -0.8 -0.7
Age at first live birth 0.5 0.9 1.3 -1.1 -0.8
Pulse wave peak to peak time 0.4 0.5 0.7 -0.8 0.5
Health satisfaction 0.4 0.5 0.7 -0.5 -0.8
Shortness of breath walking on level ground 0.0 0.0 0.1 0.3 -0.1
Qualifications: College or University degree 2.4 7.5 14.1 -3.8 0.9
Eye problems/disorders: None of the above 3.2 3.7 7.2 -2.7 -0.5
Mouth/teeth dental problems: Loose teeth 1.6 2.0 2.5 -1.2 -1.6
Emphysema/chronic bronchitis 0.4 0.4 0.4 0.6 -0.6
Medication for pain relief, constipation, heartburn 0.5 0.8 1.2 -0.6 -1.1
Neck or shoulder pain in last month 0.7 1.0 1.3 0.9 1.1
Medication: Blood pressure 0.1 0.2 0.4 0.1 -0.6
Angina (self-reported) 0.8 1.0 1.7 1.3 -0.5
Migraine (self-reported) 1.1 1.4 2.7 1.6 -0.4
Medication: Ibuprofen 1.4 1.7 3.0 -1.7 0.6
Medication: Allopurinol 0.2 0.3 0.5 -0.7 -0.3
Medication: Omeprazole 0.6 0.7 1.3 -0.4 1.1
Medication: Seretide 50 evohaler 0.7 0.8 1.1 -1.1 -0.7
Mean time to correctly identify matches 0.7 1.3 2.0 -1.4 -0.7
Heart disease (mother) 0.2 0.2 0.4 -0.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.0 1.0 0.8
Whole body fat mass 1.9 7.8 15.0 -3.9 -0.7
Leg fat mass (right) 1.4 5.3 10.4 -3.2 -0.4
Arm predicted mass (right) 1.7 8.5 16.4 -4.0 0.8
Pulse rate, automated reading 0.8 2.6 3.2 1.8 -1.4
Alcohol intake frequency. 1.0 2.4 2.6 1.6 -1.5
Comparative height size at age 10 1.0 5.7 11.3 -3.4 -0.3
Number of full sisters 1.7 2.1 3.0 -1.7 -1.1
Suffer from ‘nerves’ 0.2 0.4 0.4 -0.7 0.5
Overall health rating 0.2 0.5 0.7 0.8 -0.6
Chest pain or discomfort 1.5 2.1 2.7 1.6 1.3
Had major operations 1.3 1.5 2.8 -0.6 -1.7
Age at last live birth 0.6 0.9 1.6 -1.3 -0.3
Family relationship satisfaction 0.9 1.1 1.7 0.7 -1.3
Leg pain on walking 0.6 0.7 1.5 0.1 1.2
Qualifications: NVQ or HND or HNC or equivalent 4.1 4.9 9.5 3.1 0.5
Commuting to job workplace: Car/motor vehicle 0.0 0.1 0.1 0.2 0.3
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.4 0.7 -0.3
Medication: Aspirin 0.4 0.6 1.1 -0.1 -1.1
Supplements: Vitamin C 0.6 0.7 1.2 -0.4 -1.1
Knee pain experienced in last month 0.2 0.4 0.7 -0.1 0.9
Hypertension (Self-reported) 0.4 1.2 1.8 -0.8 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.4 0.3 0.6
Illnesses of father: Heart disease 0.1 0.2 0.4 0.6 0.1
Illnesses of siblings: Diabetes 0.4 0.5 0.8 -0.4 -0.9
Smoking status: Previous 1.3 1.9 2.2 1.3 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 2.3 4.8 9.5 -3.1 0.2
Whole body fat-free mass 1.5 8.6 16.9 -4.1 0.6
Leg fat-free mass (right) 2.1 11.1 22.2 -4.7 -0.1
Arm fat percentage (left) 1.4 5.6 10.7 -3.3 -0.7
Average weekly red wine intake 0.6 0.9 1.6 0.4 -1.2
Handedness (chirality/laterality): Left-handed 0.7 0.9 1.5 0.5 -1.2
Mood swings 1.4 2.5 3.2 1.8 1.4
Loneliness, isolation 1.1 1.6 3.0 0.3 1.7
Long-standing illness, disability or infirmity 0.8 1.2 2.3 -1.5 -0.2
Ever had bowel cancer screening 0.7 0.9 1.4 -1.2 0.6
Diabetes diagnosed by doctor 0.2 0.4 0.8 -0.9 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 0.3 -0.6
Friendships satisfaction 0.6 0.8 1.1 0.7 -1.1
Qualifications: nursing, teaching 1.0 1.6 3.0 0.4 -1.7
Commuting to job workplace: Walk 0.6 0.6 0.8 -0.6 -0.9
Eye problems/disorders: Cataract 0.5 0.5 1.1 1.0 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.2 -1.1 0.9
Medication for cholesterol 0.4 0.7 1.2 -1.1 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 -0.3 0.7
Back pain experienced in last month 0.5 0.8 0.9 0.8 -0.9
Mineral and other dietary supplements 0.2 0.3 0.6 -0.2 -0.8
Breast cancer (self-reported) 0.3 0.4 0.4 -0.6 -0.6
Asthma (self-reported) 0.1 0.3 0.6 0.8 0.1
Osteoporosis (self-reported) 1.2 1.5 2.3 1.5 0.8
Osteoarthritis (self-reported) 0.1 0.1 0.1 -0.3 0.2
Medication: Aspirin 0.3 0.4 0.8 -0.1 -0.9
Medication: Gliclazide 0.5 0.6 1.0 -0.3 -1.0
Illnesses of father: None of the above (group 1) 3.3 4.1 7.8 -2.8 0.6
Smoking status: Current 0.3 0.5 0.9 -1.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.0 2.5 -1.3 1.6
Whole body water mass 1.6 9.2 18.1 -4.2 0.5
Leg predicted mass (right) 2.0 10.9 21.7 -4.7 -0.0
Arm fat mass (left) 2.2 9.2 18.2 -4.3 -0.5
Number of self-reported non-cancer illnesses 0.5 0.9 1.1 0.8 -1.0
Average weekly champagne plus white wine intake 0.5 0.6 0.9 -0.6 0.9
Miserableness 0.7 1.2 2.4 1.5 0.3
Guilty feelings 1.2 1.9 3.1 0.8 1.8
Wears glasses or contact lenses 0.5 0.6 0.7 -0.9 -0.7
Ever taken oral contraceptive pill 0.1 0.1 0.1 -0.3 -0.3
Hearing aid user 0.3 0.3 0.5 -0.4 0.7
Mother’s age at death 0.5 0.6 1.0 -1.0 0.3
Financial situation satisfaction 2.3 2.9 5.2 2.3 -0.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.6 0.8 0.1
Commuting to job workplace: Public transport 0.1 0.1 0.1 -0.4 -0.1
Eye problems/disorders: Glaucoma 2.2 2.7 3.8 2.0 1.2
Medication: Blood pressure 0.2 0.4 0.9 -0.9 -0.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.6 -0.8 0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.2 1.4 1.2 1.0
High cholesterol (Self-reported) 1.4 2.5 3.4 1.9 1.2
Medication: Bendroflumethiazide 0.3 0.4 0.5 0.7 -0.7
Medication: Paracetamol 1.4 2.1 3.6 1.9 0.8
Medication: Lisinopril 1.3 1.7 3.3 0.4 -1.8
Medication: Atorvastatin 0.0 0.1 0.1 0.3 0.0
Illnesses of father: High blood pressure 0.7 0.8 1.7 1.3 0.2
Alcohol drinker status: Never 0.8 1.0 1.0 1.0 -1.0
Ever smoked 1.1 1.9 1.9 1.4 -1.4
Basal metabolic rate 1.8 10.2 20.2 -4.5 0.5
Leg fat percentage (left) 0.7 2.6 5.2 -2.3 0.0
Arm fat-free mass (left) 1.9 9.9 19.4 -4.4 0.5
Number of operations (self-reported) 0.8 1.2 2.2 -0.3 -1.5
Average weekly beer plus cider intake 1.3 1.9 3.2 0.7 -1.8
Irritability 2.2 3.7 6.8 2.6 0.8
Risk taking 0.5 0.7 1.0 -0.6 1.0
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.5 0.3 -0.7
Fractured/broken bones in last 5 years 0.4 0.5 1.0 -0.3 -1.0
Age started oral contraceptive pill 0.8 1.0 1.3 -0.7 -1.2
Diastolic blood pressure, automated reading 0.2 0.5 0.9 0.1 -1.0
Ever depressed for a whole week 1.0 1.2 2.3 1.5 0.2
Unable to work because of sickness or disability 1.1 1.4 1.7 -1.3 -1.1
Commuting to job workplace: Cycle 0.8 1.0 2.0 -1.4 -0.1
Myopia 0.4 0.6 1.1 -1.1 -0.1
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.3 0.1 1.5
Cholesterol lowering medication 0.4 0.5 0.9 0.9 -0.4
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 3.5 -0.6 1.9
Pain experienced in last month 0.1 0.1 0.3 0.1 -0.5
Supplements: Calcium 1.9 2.1 3.5 0.9 1.9
Basal cell carcinoma (self-reported) 0.5 0.6 0.7 0.7 0.8
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.2 0.8 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.3 0.3 -0.5
Heart disease (siblings) 0.3 0.3 0.7 0.8 -0.0
Alcohol drinker status: Previous 1.1 1.2 1.5 1.2 -1.0
Pack years of smoking 1.5 2.1 3.1 -1.8 -1.1
Impedance of whole body 0.8 4.0 8.0 2.8 0.3
Leg fat mass (left) 1.4 5.6 11.1 -3.3 -0.3
Arm predicted mass (left) 2.0 10.2 20.0 -4.5 0.6