TWAS hub - SSBP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.230	0.076	0.0054	0.149	NA	0.103	NA	0.110	3.3e-07	NA	2.3e-05	NA	1.3e-05
2	GTEx	Liver	0.469	0.131	0.0023	0.054	NA	0.248	NA	0.104	1.3e-02	NA	1.4e-07	NA	7.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Comparative body size at age 10	6.1	16.9	28.0	-5.3	2.4
Body Mass Index (BMI) (2010)	4.6	6.3	12.5	-3.5	-0.3
Noisy workplace	4.1	5.0	9.6	3.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	4.1	4.9	9.5	3.1	0.5
HbA1C	3.8	4.3	7.6	2.8	-0.9
Worry (Nagel 2018)	3.7	7.8	12.4	3.5	1.8
Age when periods started (menarche)	3.7	9.0	17.5	4.2	-0.7
Supplements: Zinc	3.6	3.9	7.5	-0.5	2.7
Supplements: Glucosamine	3.6	4.7	5.9	-2.4	1.8
Illnesses of father: None of the above (group 1)	3.3	4.1	7.8	-2.8	0.6
Eye problems/disorders: None of the above	3.2	3.7	7.2	-2.7	-0.5
Neuroticism (Nagel 2018)	3.1	7.3	10.0	3.2	2.1
Diabetes (father)	3.0	3.8	7.3	2.7	-0.4
Medication: Lansoprazole	2.7	3.1	5.1	2.2	-1.1
Townsend deprivation index at recruitment	2.5	3.5	5.3	1.3	-2.3
Mouth/teeth dental problems: Dentures	2.5	4.1	5.0	-1.8	-2.2
Depression (Nagel 2018)	2.4	3.5	6.8	0.5	2.6
Triglycerides	2.4	3.9	7.0	-2.6	-1.0
Qualifications: College or University degree	2.4	7.5	14.1	-3.8	0.9
Average weekly fortified wine intake	2.3	2.7	3.7	-1.3	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	9.5	-3.1	0.2
Financial situation satisfaction	2.3	2.9	5.2	2.3	-0.8
BMI	2.2	12.6	25.0	-5.0	-0.5
Weight	2.2	10.8	21.5	-4.6	-0.2
Glaucoma (self-reported)	2.2	2.5	4.0	2.0	1.0
Arm fat mass (left)	2.2	9.2	18.2	-4.3	-0.5
Eye problems/disorders: Glaucoma	2.2	2.7	3.8	2.0	1.2
Irritability	2.2	3.7	6.8	2.6	0.8
Serious illness, injury or assault to yourself	2.1	2.6	4.0	-2.0	-1.1
Waist circumference	2.1	7.8	15.2	-3.9	-0.6
Arm fat mass (right)	2.1	8.7	17.2	-4.1	-0.5
Leg fat-free mass (right)	2.1	11.1	22.2	-4.7	-0.1
Medication: Atenolol	2.0	2.5	3.1	1.8	1.3
Leg predicted mass (left)	2.0	10.4	20.6	-4.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.5	3.0	1.7	1.4
Leg predicted mass (right)	2.0	10.9	21.7	-4.7	-0.0
Arm predicted mass (left)	2.0	10.2	20.0	-4.5	0.6
Ever used hormone-replacement therapy (HRT)	1.9	2.5	2.6	1.6	-1.5
Leg fat-free mass (left)	1.9	10.3	20.4	-4.5	-0.4
Worrier / anxious feelings	1.9	3.6	6.8	2.6	0.6
Medication: Paracetamol	1.9	3.1	5.7	2.4	0.7
Whole body fat mass	1.9	7.8	15.0	-3.9	-0.7
Arm fat-free mass (left)	1.9	9.9	19.4	-4.4	0.5
Supplements: Calcium	1.9	2.1	3.5	0.9	1.9
Body mass index (BMI)	1.8	7.6	14.7	-3.8	-0.7
Basal metabolic rate	1.8	10.2	20.2	-4.5	0.5
Arm predicted mass (right)	1.7	8.5	16.4	-4.0	0.8
Number of full sisters	1.7	2.1	3.0	-1.7	-1.1
Alzheimer’s Disease (in father)	1.6	1.8	2.8	-0.9	1.7
Pack years adult smoking proportion	1.6	2.4	4.2	-2.0	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	4.1	-0.3	2.0
Nervous feelings	1.6	3.0	4.5	2.1	1.2
Neuroticism score	1.6	3.3	5.4	2.3	1.0
Arm fat-free mass (right)	1.6	8.1	15.7	-4.0	0.7
Mouth/teeth dental problems: Loose teeth	1.6	2.0	2.5	-1.2	-1.6
Whole body water mass	1.6	9.2	18.1	-4.2	0.5
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.5	-0.6	1.9
Crohns Disease (2017)	1.5	3.3	5.7	1.0	-2.4
Neuroticism	1.5	3.6	5.3	2.3	1.4
Trunk fat mass	1.5	6.6	12.8	-3.6	-0.6
Arm fat percentage (right)	1.5	5.8	10.7	-3.3	-1.0
Falls in the last year	1.5	2.0	4.0	-0.2	-2.0
Qualifications: A levels/AS levels or equivalent	1.5	3.3	6.4	-2.5	0.5
Chest pain or discomfort	1.5	2.1	2.7	1.6	1.3
Whole body fat-free mass	1.5	8.6	16.9	-4.1	0.6
Pack years of smoking	1.5	2.1	3.1	-1.8	-1.1
Medication: Metformin	1.4	1.9	3.7	-1.9	0.4
Impedance of leg (left)	1.4	6.6	11.2	3.4	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.4	-1.5	1.1
Exposure to tobacco smoke outside home	1.4	1.9	2.0	1.4	1.3
Worry too long after embarrassment	1.4	2.3	4.7	2.2	0.1
Medication: Ibuprofen	1.4	1.7	3.0	-1.7	0.6
Leg fat mass (right)	1.4	5.3	10.4	-3.2	-0.4
Arm fat percentage (left)	1.4	5.6	10.7	-3.3	-0.7
Mood swings	1.4	2.5	3.2	1.8	1.4
High cholesterol (Self-reported)	1.4	2.5	3.4	1.9	1.2
Medication: Paracetamol	1.4	2.1	3.6	1.9	0.8
Leg fat mass (left)	1.4	5.6	11.1	-3.3	-0.3
Impedance of leg (right)	1.3	6.1	11.6	3.4	0.8
Trunk fat percentage	1.3	5.4	9.7	-3.1	-1.0
Relative age voice broke	1.3	2.0	3.6	1.9	-0.6
Heart attack	1.3	1.7	3.0	0.6	-1.7
Hip circumference	1.3	5.8	11.4	-3.4	-0.4
Had major operations	1.3	1.5	2.8	-0.6	-1.7
Smoking status: Previous	1.3	1.9	2.2	1.3	-1.5
Medication: Lisinopril	1.3	1.7	3.3	0.4	-1.8
Average weekly beer plus cider intake	1.3	1.9	3.2	0.7	-1.8
Bipolar Disorder (2018)	1.2	1.9	3.2	-0.8	-1.8
HDL Cholesterol	1.2	2.0	3.3	1.8	0.9
Relative age of first facial hair	1.2	2.4	3.2	1.8	-1.3
Financial difficulties in last 2 years	1.2	1.6	2.6	1.6	-0.7
Trunk fat-free mass	1.2	6.6	11.9	-3.5	1.1
Time employed in main current job	1.2	1.4	2.0	-0.8	1.4
Osteoporosis (self-reported)	1.2	1.5	2.3	1.5	0.8
Guilty feelings	1.2	1.9	3.1	0.8	1.8
Reaction Time	1.1	2.1	4.1	-2.0	-0.1
Mean Putamen Volume	1.1	1.3	2.5	-1.6	0.3
Trunk predicted mass	1.1	6.4	11.4	-3.4	1.2
Tense / ‘highly strung’	1.1	1.9	2.0	1.3	1.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.5	1.6	0.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.5	-0.3	-1.6
Body fat percentage	1.1	4.5	8.5	-2.9	-0.7
Migraine (self-reported)	1.1	1.4	2.7	1.6	-0.4
Loneliness, isolation	1.1	1.6	3.0	0.3	1.7
Ever smoked	1.1	1.9	1.9	1.4	-1.4
Unable to work because of sickness or disability	1.1	1.4	1.7	-1.3	-1.1
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.2	0.8	-1.5
Alcohol drinker status: Previous	1.1	1.2	1.5	1.2	-1.0
Depressed Affect (Nagel 2018)	1.0	2.2	2.8	1.7	1.3
Alzheimer’s Disease (including proxy)	1.0	1.5	2.6	-1.6	-0.6
Crohns Disease (2012)	1.0	1.6	3.2	0.2	-1.8
Medication for hormone replacement therapy	1.0	1.1	2.0	1.4	-0.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.3	1.1	1.1
Illnesses of mother	1.0	1.3	2.5	-0.1	1.6
Loud music exposure frequency	1.0	1.1	1.8	1.3	0.7
Alcohol intake frequency.	1.0	2.4	2.6	1.6	-1.5
Comparative height size at age 10	1.0	5.7	11.3	-3.4	-0.3
Qualifications: nursing, teaching	1.0	1.6	3.0	0.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	2.5	-1.3	1.6
Ever depressed for a whole week	1.0	1.2	2.3	1.5	0.2
Coronary Artery Disease (CAD)	0.9	1.1	1.7	1.3	0.7
Neuroticism (2016)	0.9	1.3	2.5	1.6	0.2
Sensitivity / hurt feelings	0.9	1.5	2.0	1.4	0.9
Qualifications: CSEs or equivalent	0.9	1.2	1.5	1.2	-1.0
Illnesses of siblings	0.9	1.3	1.6	-1.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.8	1.7	-0.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.4	0.1	1.5
Family relationship satisfaction	0.9	1.1	1.7	0.7	-1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.4	1.2	1.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.3	-0.1	1.5
Severe depression (siblings)	0.8	0.9	1.5	0.6	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.3	-0.5	1.5
Hair/balding pattern: Pattern 2	0.8	1.0	1.9	-0.4	-1.4
Mouth/teeth dental problems	0.8	1.2	2.2	1.5	0.5
Angina (self-reported)	0.8	1.0	1.7	1.3	-0.5
Pulse rate, automated reading	0.8	2.6	3.2	1.8	-1.4
Long-standing illness, disability or infirmity	0.8	1.2	2.3	-1.5	-0.2
Alcohol drinker status: Never	0.8	1.0	1.0	1.0	-1.0
Number of operations (self-reported)	0.8	1.2	2.2	-0.3	-1.5
Age started oral contraceptive pill	0.8	1.0	1.3	-0.7	-1.2
Commuting to job workplace: Cycle	0.8	1.0	2.0	-1.4	-0.1
Impedance of whole body	0.8	4.0	8.0	2.8	0.3
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	-0.1	-1.3
Age at First Birth	0.7	1.0	1.4	-1.2	0.8
Fasting Glucose	0.7	0.9	1.6	-1.3	-0.4
Blood White Count	0.7	5.0	5.3	2.2	-2.3
Waist Hip Ratio (WHR)	0.7	3.3	6.4	-2.5	0.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.8	-1.4	0.0
Sitting height	0.7	4.7	5.1	-2.2	2.1
Chronic bronchitis/emphysema (father)	0.7	0.9	1.5	0.5	-1.2
Past tobacco smoking	0.7	1.4	1.8	-1.0	1.3
Alcohol usually taken with meals	0.7	1.2	1.8	-1.3	-0.8
Qualifications: None of the above	0.7	1.5	2.4	-1.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.0	0.5	1.4
Happiness	0.7	0.8	1.4	1.2	0.5
Length of working week for main job	0.7	0.8	1.0	-1.0	0.8
Hair/balding pattern: Pattern 4	0.7	1.6	2.5	-1.6	0.9
Neck or shoulder pain in last month	0.7	1.0	1.3	0.9	1.1
Medication: Seretide 50 evohaler	0.7	0.8	1.1	-1.1	-0.7
Mean time to correctly identify matches	0.7	1.3	2.0	-1.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.0	1.0	0.8
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.5	0.5	-1.2
Ever had bowel cancer screening	0.7	0.9	1.4	-1.2	0.6
Miserableness	0.7	1.2	2.4	1.5	0.3
Illnesses of father: High blood pressure	0.7	0.8	1.7	1.3	0.2
Leg fat percentage (left)	0.7	2.6	5.2	-2.3	0.0
Breast Cancer	0.6	1.4	2.8	-0.3	-1.7
LDL Cholesterol	0.6	0.9	1.8	-1.4	-0.1
Lupus	0.6	0.9	1.8	-0.2	1.3
Allergy or Eczema	0.6	1.5	2.2	1.5	-0.9
Angina	0.6	0.8	1.2	1.1	-0.6
Medication: Co-codamol	0.6	0.7	0.9	-0.7	0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-0.1	-1.2
High blood pressure (mother)	0.6	0.9	1.6	-1.3	0.4
Father’s age at death	0.6	0.9	1.5	-0.4	1.2
Exposure to tobacco smoke at home	0.6	0.7	0.8	-0.9	0.7
Medication: Amlodipine	0.6	0.8	1.3	-1.2	-0.6
High blood pressure (siblings)	0.6	0.8	1.2	1.1	-0.7
Medication: Omeprazole	0.6	0.7	1.3	-0.4	1.1
Age at last live birth	0.6	0.9	1.6	-1.3	-0.3
Leg pain on walking	0.6	0.7	1.5	0.1	1.2
Supplements: Vitamin C	0.6	0.7	1.2	-0.4	-1.1
Average weekly red wine intake	0.6	0.9	1.6	0.4	-1.2
Friendships satisfaction	0.6	0.8	1.1	0.7	-1.1
Commuting to job workplace: Walk	0.6	0.6	0.8	-0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.2	-1.1	0.9
Ovarian Cancer	0.5	0.6	1.3	0.1	-1.1
Blood Eosinophil Count	0.5	4.2	4.9	-2.2	-1.9
Fed-up feelings	0.5	0.8	1.5	1.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.6	0.8	-0.7
Multivitamins +/- minerals	0.5	0.6	0.8	-0.6	0.9
Prospective memory result	0.5	0.6	1.2	0.1	-1.1
Lung cancer (father)	0.5	0.5	0.7	0.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	2.3	-1.5	0.8
Impedance of arm (left)	0.5	2.4	4.6	2.1	-0.3
Peak expiratory flow (PEF)	0.5	1.1	2.1	-1.5	0.0
Forced vital capacity (FVC), Best measure	0.5	1.7	1.8	-1.3	1.3
Leg fat percentage (right)	0.5	1.9	3.8	-2.0	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.6	-0.8	-0.7
Age at first live birth	0.5	0.9	1.3	-1.1	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	-0.6	-1.1
Eye problems/disorders: Cataract	0.5	0.5	1.1	1.0	-0.0
Back pain experienced in last month	0.5	0.8	0.9	0.8	-0.9
Medication: Gliclazide	0.5	0.6	1.0	-0.3	-1.0
Number of self-reported non-cancer illnesses	0.5	0.9	1.1	0.8	-1.0
Average weekly champagne plus white wine intake	0.5	0.6	0.9	-0.6	0.9
Wears glasses or contact lenses	0.5	0.6	0.7	-0.9	-0.7
Mother’s age at death	0.5	0.6	1.0	-1.0	0.3
Risk taking	0.5	0.7	1.0	-0.6	1.0
Basal cell carcinoma (self-reported)	0.5	0.6	0.7	0.7	0.8
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.2	0.3	-1.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	0.2	1.0
Systolic Blood Pressure	0.4	1.8	3.1	0.7	-1.8
Hypothyroidism (self reported)	0.4	0.9	1.6	-1.3	0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.2	-1.1	-0.6
Chronotype (morning person)	0.4	0.9	1.2	-0.7	-1.1
High blood pressure	0.4	1.1	2.0	-0.5	-1.4
Number of incorrect matches in round	0.4	0.6	1.0	-0.5	1.0
Allergy	0.4	1.0	1.4	-1.2	0.8
Pain all over the body in last month	0.4	0.5	0.5	0.7	0.7
Diabetes (self-reported)	0.4	0.6	1.3	-1.1	-0.0
Fluid intelligence score	0.4	0.8	1.5	-1.2	0.2
Impedance of arm (right)	0.4	1.9	3.1	1.8	-0.8
Standing height	0.4	3.6	5.8	-2.4	1.1
Birth weight of first child	0.4	0.8	1.6	-0.2	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.0	1.0	-0.6
Birth weight	0.4	1.0	1.8	0.3	1.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.1	1.0	-0.6
Number of children fathered	0.4	0.4	0.6	-0.8	-0.5
Pulse wave peak to peak time	0.4	0.5	0.7	-0.8	0.5
Health satisfaction	0.4	0.5	0.7	-0.5	-0.8
Emphysema/chronic bronchitis	0.4	0.4	0.4	0.6	-0.6
Medication: Aspirin	0.4	0.6	1.1	-0.1	-1.1
Hypertension (Self-reported)	0.4	1.2	1.8	-0.8	-1.4
Illnesses of siblings: Diabetes	0.4	0.5	0.8	-0.4	-0.9
Medication for cholesterol	0.4	0.7	1.2	-1.1	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.6	-0.8	0.7
Fractured/broken bones in last 5 years	0.4	0.5	1.0	-0.3	-1.0
Myopia	0.4	0.6	1.1	-1.1	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.3	0.1	1.5
Cholesterol lowering medication	0.4	0.5	0.9	0.9	-0.4
Major Depression (MDD)	0.3	0.4	0.7	-0.2	-0.9
Primary Biliary Cirrhosis	0.3	0.5	0.8	0.4	-0.9
Heel T-Score	0.3	2.1	2.7	-1.6	1.2
Tanning	0.3	3.7	7.3	2.7	0.5
Hand grip strength (left)	0.3	0.7	0.8	0.7	0.9
Current tobacco smoking	0.3	0.6	1.1	-1.1	-0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.7	0.8	-0.7
Had menopause	0.3	0.3	0.5	0.3	-0.7
Forced vital capacity (FVC)	0.3	1.3	2.2	-0.6	1.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.9	0.2
Medication: Ramipril	0.3	0.4	0.6	-0.3	0.8
Medication: Simvastatin	0.3	0.5	0.7	0.8	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.3	-0.9	1.2
Blood clot in the leg (DVT)	0.3	0.3	0.4	0.5	-0.7
Gout (self-reported)	0.3	0.5	1.0	-1.0	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	-1.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	-0.3	0.7
Breast cancer (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Medication: Aspirin	0.3	0.4	0.8	-0.1	-0.9
Smoking status: Current	0.3	0.5	0.9	-1.0	0.2
Hearing aid user	0.3	0.3	0.5	-0.4	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.8	0.1
Medication: Bendroflumethiazide	0.3	0.4	0.5	0.7	-0.7
Heart disease (siblings)	0.3	0.3	0.7	0.8	-0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	0.6	-0.5	-0.7
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	0.5	-0.8
Prostate Cancer	0.2	0.3	0.4	-0.5	0.6
Blood Platelet Count	0.2	2.4	3.4	1.2	-1.8
Height	0.2	4.8	5.9	-2.4	1.9
Number of treatments/medications taken	0.2	0.3	0.5	0.7	-0.4
Average weekly spirits intake	0.2	0.2	0.4	0.2	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.7	-0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.5	-0.7	-0.1
Number of live births	0.2	0.2	0.4	0.7	-0.0
Asthma	0.2	0.3	0.5	0.7	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.6	-0.3
Headache pain in last month	0.2	0.3	0.7	0.8	0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.4	0.6	0.4
Medication: Allopurinol	0.2	0.3	0.5	-0.7	-0.3
Heart disease (mother)	0.2	0.2	0.4	-0.1	0.6
Suffer from ‘nerves’	0.2	0.4	0.4	-0.7	0.5
Overall health rating	0.2	0.5	0.7	0.8	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.7	-0.3
Knee pain experienced in last month	0.2	0.4	0.7	-0.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.3	0.6
Diabetes diagnosed by doctor	0.2	0.4	0.8	-0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.3	-0.6
Mineral and other dietary supplements	0.2	0.3	0.6	-0.2	-0.8
Medication: Blood pressure	0.2	0.4	0.9	-0.9	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.3	-0.7
Diastolic blood pressure, automated reading	0.2	0.5	0.9	0.1	-1.0
Rheumatoid Arthritis	0.1	0.2	0.4	0.6	-0.2
Ulcerative Colitis	0.1	0.1	0.2	0.1	0.4
Blood Red Count	0.1	1.2	1.5	-1.2	-1.0
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.9	0.3
Lung FVC	0.1	0.7	1.4	1.2	-0.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.0	0.5
Systolic blood pressure, automated reading	0.1	0.3	0.6	0.1	-0.8
Diabetes (mother)	0.1	0.1	0.2	0.1	-0.4
Hand grip strength (right)	0.1	0.2	0.3	0.6	0.1
Maternal smoking around birth	0.1	0.1	0.2	0.4	0.1
Taking other prescription medications	0.1	0.2	0.3	0.4	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.3	0.5	0.6
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	-0.3	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.6	-0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.4	0.5
Pulse rate	0.1	0.2	0.5	0.7	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	0.1	0.6
Breastfed as a baby	0.1	0.1	0.2	0.4	-0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.2	-0.5	-0.3
Medication: Blood pressure	0.1	0.2	0.4	0.1	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.4	0.6	0.1
Asthma (self-reported)	0.1	0.3	0.6	0.8	0.1
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.3	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.3	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.4	-0.1
Pain experienced in last month	0.1	0.1	0.3	0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.3	-0.5
Schizophrenia (2018)	0.0	0.1	0.1	-0.0	0.3
Ulcerative Colitis (UC)	0.0	0.0	0.1	-0.3	0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	0.0	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.1	-0.2	0.0
Schizophrenia (2014)	0.0	0.1	0.1	-0.2	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.1	-0.2	0.2
Smoking Status	0.0	0.1	0.2	0.2	0.4
Cardiovascular Disease	0.0	0.1	0.2	0.1	-0.5
Respiratory disease	0.0	0.0	0.0	0.1	-0.1
Hair Pigment	0.0	0.2	0.3	0.6	0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.1	0.0
Vitamin and mineral supplements	0.0	0.1	0.1	0.1	0.3
Had other major operations	0.0	0.0	0.0	0.1	-0.2
Medication: Cholesterol lowering	0.0	0.0	0.0	0.1	0.1
Depression (self-reported)	0.0	0.0	0.1	0.1	0.3
Pulse wave reflection index	0.0	0.0	0.1	0.0	-0.3
Number of full brothers	0.0	0.0	0.0	-0.2	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.1	0.3	-0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.1	0.1	0.2	0.3
Medication: Atorvastatin	0.0	0.1	0.1	0.3	0.0

Hub : Genes

SSBP3

Models

Trait associations