TWAS hub - STAB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.131	0.0500	1.6e-03	0.104	0.060	0.059	NA	0.083	1.3e-06	2.4e-04	2.6e-04	NA	1.5e-05
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.168	0.0375	6.0e-12	0.125	0.099	0.097	NA	0.111	7.8e-14	3.2e-11	5.5e-11	NA	2.0e-12
3	TCGA	Lung Adenocarcinoma	0.102	0.0304	6.6e-07	0.074	0.025	0.114	NA	0.062	5.3e-09	6.1e-04	3.0e-13	NA	9.3e-08
4	TCGA	Lung Squamous Cell Carcinoma	0.146	0.0344	6.3e-10	0.107	0.086	0.089	NA	0.080	4.0e-12	5.8e-10	2.7e-10	NA	2.3e-09
5	TCGA	Rectum Adenocarcinoma	0.344	0.1120	5.0e-03	0.121	0.111	0.092	NA	0.106	9.4e-04	1.5e-03	3.6e-03	NA	1.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bilateral oophorectomy (both ovaries removed)	6.5	7.6	10.8	3.3	3.1	2.3	2.8	2.0
Glaucoma (self-reported)	6.0	7.0	8.9	-2.4	-2.3	-3.0	-2.7	-2.8
Diabetes (self-reported)	4.7	7.3	9.2	3.0	2.9	2.1	2.8	2.5
Impedance of leg (left)	4.6	22.5	31.7	-5.6	-5.6	-4.2	-4.6	-3.2
Impedance of leg (right)	4.5	22.0	31.8	-5.6	-5.6	-4.0	-4.6	-3.1
Reason for reducing amount of alcohol drunk: Health precaution	3.8	4.4	6.8	2.6	2.3	2.1	2.0	1.3
Eye problems/disorders: Glaucoma	3.7	4.4	6.5	-2.0	-1.8	-2.6	-2.0	-2.1
Deep venous thrombosis (DVT) (self-reported)	3.7	4.7	6.0	2.3	2.1	2.4	2.2	1.7
Medication: Metformin	3.6	5.0	6.0	2.4	2.4	2.0	2.2	2.2
Ever had bowel cancer screening	3.6	4.3	5.4	2.3	2.2	1.8	2.3	1.7
Hypothyroidism/myxoedema (self-reported)	3.5	6.8	8.5	-2.8	-2.9	-2.8	-2.4	-2.1
Blood clot in the leg (DVT)	3.3	4.3	5.8	2.3	2.0	2.4	2.1	1.5
Number of operations (self-reported)	3.3	4.8	8.2	1.9	1.7	2.0	2.4	2.9
Bipolar Disorder or Schizophrenia	3.1	7.6	13.2	-3.2	-3.6	-2.5	-2.4	-1.5
Hypothyroidism (self reported)	3.0	7.0	8.5	-2.8	-2.9	-2.6	-2.8	-2.1
Mouth/teeth dental problems: Bleeding gums	2.9	3.8	5.8	2.3	2.4	2.0	1.8	0.8
Bipolar Disorder (2018)	2.8	4.4	6.8	-2.5	-2.6	-2.0	-1.8	-1.4
Medication: Levothyroxine sodium	2.7	4.6	5.5	-2.3	-2.3	-2.2	-1.9	-2.0
Financial difficulties in last 2 years	2.7	3.7	5.1	-2.0	-1.9	-2.1	-2.2	-1.2
Time employed in main current job	2.7	3.1	8.3	-1.3	-1.4	-2.9	-1.3	-1.4
Multivitamins +/- minerals	2.6	3.3	4.4	-2.0	-2.0	-2.1	-1.6	-1.3
Depression (self-reported)	2.6	3.1	7.4	1.5	1.6	2.7	1.4	1.1
Supplements: Fish oil (including cod liver oil)	2.6	3.4	4.5	-2.1	-2.0	-2.0	-1.8	-1.0
Schizophrenia (2014)	2.5	5.5	8.9	-2.5	-3.0	-2.5	-1.9	-1.5
Impedance of whole body	2.5	13.0	18.2	-4.2	-4.3	-2.9	-3.6	-2.7
Current tobacco smoking	2.4	3.9	6.2	-2.0	-2.0	-2.5	-2.1	-0.8
Medication: Ramipril	2.4	3.0	4.4	1.7	1.7	2.1	1.5	1.6
Diastolic blood pressure, automated reading	2.4	7.4	9.2	-2.8	-3.0	-2.6	-2.5	-2.7
Medication: Co-codamol	2.3	2.7	4.4	2.0	2.1	1.1	1.6	1.1
Medication: Atenolol	2.3	2.9	4.6	1.7	1.7	1.2	2.1	1.6
Had major operations	2.3	2.7	3.6	1.9	1.7	1.5	1.6	1.4
Type 2 Diabetes (T2D) (2018)	2.2	4.2	5.6	2.0	2.1	1.8	2.0	2.4
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	5.1	-2.0	-2.3	-1.2	-1.9	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	5.1	-1.4	-1.7	-1.1	-1.4	-2.2
Breast cancer (self-reported)	2.2	2.6	5.5	1.4	1.6	2.4	1.2	1.3
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.2	1.6	1.2	2.0	1.7	1.2
Waist Hip Ratio (WHR)	2.0	9.0	12.0	-3.5	-3.3	-3.1	-3.1	-1.9
Chronotype (morning person)	2.0	4.7	6.1	2.3	2.5	2.1	2.2	1.6
Illnesses of father: Heart disease	2.0	2.8	3.9	1.8	2.0	1.5	1.7	1.3
Smoking status: Current	2.0	3.1	5.8	-1.8	-1.7	-2.4	-1.8	-0.6
Lupus	1.9	2.9	4.4	-1.6	-1.3	-2.1	-2.0	-1.5
Maternal smoking around birth	1.9	2.8	4.3	-1.9	-2.1	-1.7	-1.4	-1.0
Stomach or abdominal pain in last month	1.9	2.4	3.3	-1.1	-1.5	-1.7	-1.8	-1.5
Heart disease (mother)	1.9	2.4	3.6	1.7	1.7	0.8	1.3	1.9
Medication for cholesterol	1.9	2.9	3.9	-1.9	-2.0	-1.8	-1.6	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	6.4	-1.7	-1.6	-2.0	-2.3	-2.5
Leg fat percentage (right)	1.8	6.4	10.2	-2.4	-2.1	-2.8	-1.9	-3.2
Diabetes diagnosed by doctor	1.8	3.0	4.5	2.1	2.1	0.8	1.7	1.7
Ever had hysterectomy (womb removed)	1.7	2.0	3.0	1.7	1.7	0.9	1.3	1.2
Number of full sisters	1.7	2.1	2.8	-1.4	-1.5	-1.4	-1.2	-1.7
Schizophrenia (2018)	1.6	3.4	6.6	-2.1	-2.6	-1.6	-1.6	-0.9
Blood White Count	1.6	11.9	17.4	-4.2	-3.7	-3.0	-3.5	-2.6
Diabetes (father)	1.6	2.0	2.5	-1.4	-1.6	-1.5	-1.5	-1.1
Illnesses of mother	1.6	2.0	3.5	-1.9	-1.8	-0.8	-1.4	-0.8
Knee pain experienced in last month	1.6	2.5	3.7	-1.6	-1.6	-1.1	-1.9	-1.7
Eye problems/disorders: Cataract	1.6	1.9	2.8	1.5	1.6	0.9	1.7	1.0
Medication: Blood pressure	1.6	3.0	3.7	1.7	1.5	1.8	1.9	1.8
Leg fat percentage (left)	1.6	5.6	9.2	-2.2	-1.9	-2.7	-1.8	-3.0
LDL Cholesterol	1.5	2.4	4.1	-1.4	-1.3	-1.6	-1.4	-2.0
Blood Eosinophil Count	1.5	11.5	15.3	-3.4	-3.3	-3.9	-3.3	-2.9
Vitamin and mineral supplements	1.5	2.1	2.4	1.5	1.5	1.6	1.4	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.2	-1.0	-1.1	-1.3	-1.4	-2.0
Medication: Seretide 50 evohaler	1.5	1.8	2.6	-1.5	-1.2	-1.6	-1.2	-1.1
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.0	-1.4	-1.3	-0.9	-1.3	-1.7
Alcohol drinker status: Never	1.5	1.8	2.8	-1.6	-1.7	-0.6	-1.3	-1.3
Ovarian Cancer	1.4	1.8	2.4	-1.2	-1.3	-1.6	-1.4	-1.2
Smoking Status	1.4	3.4	5.5	-2.4	-2.1	-1.6	-2.1	-0.6
Father’s age at death	1.4	1.9	2.4	1.4	1.0	1.5	1.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.5	1.3	1.4	1.6	1.1	0.8
Birth weight	1.4	3.0	5.2	-1.6	-1.8	-1.4	-1.3	-2.3
Average weekly beer plus cider intake	1.4	2.1	4.1	-1.1	-1.2	-2.0	-1.0	-1.6
Mean Putamen Volume	1.3	1.5	2.2	1.5	1.4	1.1	1.2	0.9
Chest pain or discomfort	1.3	1.9	3.1	-1.3	-1.5	-1.8	-1.3	-0.9
Supplements: Vitamin C	1.3	1.6	2.2	-1.3	-1.5	-1.0	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	3.3	-1.5	-1.4	-1.8	-1.7	-1.8
Medication: Simvastatin	1.2	1.8	3.1	1.4	1.8	0.9	1.6	0.9
Tense / ‘highly strung’	1.2	2.1	3.4	-1.8	-1.7	-0.7	-1.8	-0.6
Leg fat-free mass (right)	1.2	6.6	11.5	3.4	3.1	1.6	2.5	1.7
Medication: Aspirin	1.2	1.6	2.5	1.2	1.2	0.8	1.6	1.4
Leg predicted mass (right)	1.2	6.6	11.4	3.4	3.1	1.6	2.5	1.8
Medication: Lisinopril	1.2	1.6	2.5	1.6	1.6	1.1	1.1	0.7
Alzheimer’s Disease (in mother)	1.1	1.3	3.0	1.2	0.8	1.7	0.8	0.9
Bipolar Disorder (2011)	1.1	1.1	1.8	-1.2	-1.3	-0.5	-1.3	-0.5
Average weekly red wine intake	1.1	1.7	2.5	1.2	1.4	1.6	0.9	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.2	-1.2	-1.5	-1.0	-1.2	-0.6
Leg fat-free mass (left)	1.0	5.1	9.1	3.0	2.8	1.3	2.2	1.4
Body fat percentage	1.0	3.8	7.2	-1.5	-1.3	-2.4	-1.4	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.9	-1.3	-1.7	-1.5	-1.6	-1.1
Medication: Gliclazide	1.0	1.1	2.9	1.3	1.7	0.2	1.0	-0.2
Medication: Paracetamol	1.0	1.6	4.2	-0.9	-0.9	-2.0	-1.1	-1.0
Supplements: Calcium	1.0	1.1	2.0	-1.1	-1.1	-1.4	-0.6	-0.6
Blood Platelet Count	0.9	10.9	17.2	-3.9	-4.2	-3.0	-3.4	-1.1
Medication for hormone replacement therapy	0.9	1.0	2.5	1.0	1.0	1.6	0.5	0.4
Severe depression (siblings)	0.9	1.1	2.4	-1.3	-1.5	-0.6	-0.9	0.2
Leg predicted mass (left)	0.9	4.6	8.4	2.9	2.7	1.2	2.1	1.3
Trunk fat-free mass	0.9	5.0	7.1	2.7	2.3	1.6	2.3	2.1
Age at first live birth	0.9	1.7	2.2	1.2	1.4	1.5	1.2	1.1
Qualifications: College or University degree	0.9	2.9	3.5	1.8	1.7	1.3	1.9	1.8
Whole body fat-free mass	0.9	5.1	8.2	2.9	2.6	1.4	2.3	1.8
Whole body water mass	0.9	5.1	8.3	2.9	2.6	1.4	2.3	1.8
Crohns Disease (2017)	0.8	1.8	2.7	1.3	1.3	1.3	1.6	1.0
Fasting Glucose	0.8	1.0	1.9	0.2	1.4	0.3	1.3	1.0
Primary Biliary Cirrhosis	0.8	1.1	2.2	0.6	0.6	0.9	1.5	1.4
Systolic Blood Pressure	0.8	3.8	4.5	-2.1	-2.0	-1.6	-1.9	-2.1
Trunk fat percentage	0.8	3.2	6.8	-1.3	-1.1	-2.2	-1.2	-2.6
High blood pressure (mother)	0.8	1.2	2.1	1.4	1.5	0.3	1.1	0.6
Had other major operations	0.8	0.9	1.9	0.3	0.3	1.4	1.0	1.3
Trunk predicted mass	0.8	4.8	6.9	2.6	2.3	1.5	2.3	2.1
Exposure to tobacco smoke at home	0.8	0.9	1.9	-0.8	-1.2	-0.4	-0.7	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.3	0.9	0.9	1.5	0.3	1.0
Pulse rate, automated reading	0.8	2.6	5.4	-2.2	-2.3	-0.6	-1.3	-1.0
Medication: Aspirin	0.8	1.0	1.6	0.9	0.9	0.8	1.3	1.1
Number of self-reported non-cancer illnesses	0.8	1.5	2.3	1.0	1.0	1.2	1.3	1.5
Basal cell carcinoma (self-reported)	0.8	0.9	2.1	1.0	1.4	0.4	0.8	0.8
Lung FEV1/FVC ratio	0.7	3.7	4.6	-2.0	-2.1	-1.4	-2.0	-2.0
Hand grip strength (right)	0.7	1.9	3.2	-1.2	-1.0	-1.8	-1.7	-1.0
Headache pain in last month	0.7	1.2	2.5	-0.9	-1.1	-1.6	-0.9	-0.7
Leg fat mass (right)	0.7	2.9	5.1	-1.3	-1.1	-2.2	-1.3	-2.3
Illnesses of siblings: Diabetes	0.7	0.8	1.4	0.9	0.5	1.2	1.1	0.7
Leg fat mass (left)	0.7	2.7	5.1	-1.1	-1.0	-2.3	-1.2	-2.2
Sensitivity / hurt feelings	0.6	1.0	1.7	1.3	1.3	0.7	1.1	0.2
Impedance of arm (right)	0.6	2.9	4.8	-2.1	-2.2	-0.9	-2.0	-0.9
Asthma	0.6	1.2	2.1	-1.3	-1.4	-1.0	-0.9	0.1
Medication: Lansoprazole	0.6	0.7	1.7	-0.8	-1.0	-0.3	-0.6	-1.3
Impedance of arm (left)	0.6	2.8	4.0	-2.0	-2.0	-0.8	-2.0	-1.2
High blood pressure (siblings)	0.6	0.9	3.4	0.2	0.4	-0.9	0.1	-1.9
Number of children fathered	0.6	0.7	2.0	-0.8	-0.5	-0.5	-0.5	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	-0.8	-0.8	-1.2	-0.9	0.1
Suffer from ‘nerves’	0.6	0.9	2.5	0.6	0.5	1.6	0.6	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.4	0.8	0.8	1.2	1.0	0.4
Long-standing illness, disability or infirmity	0.6	0.9	1.2	0.9	0.7	0.9	1.1	1.0
Basal metabolic rate	0.6	3.4	6.0	2.4	2.2	0.9	1.9	1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.1	-0.6	-0.9	-1.1	-0.7	-0.9
Alcohol drinker status: Previous	0.6	0.6	0.9	-1.0	-0.8	-0.8	-0.9	-0.5
Worry (Nagel 2018)	0.5	1.0	2.0	-1.3	-1.4	-0.1	-0.9	0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.4	1.0	1.2	0.4	0.5	-0.0
Hand grip strength (left)	0.5	1.4	2.7	-1.0	-1.1	-1.1	-1.7	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.1	-0.7	-0.6	-0.9	-1.0	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.8	-0.7	-0.6	-1.3	-0.6	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.2	-0.8	-0.7	-0.8	-1.0	-1.1
Hearing difficulty/problems with background noise	0.5	0.7	1.7	-0.3	-0.1	-1.1	-0.8	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.9	-1.0	-0.7	-0.9	-1.4	-1.4
Pain all over the body in last month	0.5	0.5	0.7	0.8	0.7	-0.4	0.8	0.7
Peak expiratory flow (PEF)	0.5	1.2	1.7	-0.7	-0.9	-1.2	-1.2	-1.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.4	-1.1	-1.2	-0.2	-0.6	0.6
Number of full brothers	0.5	0.6	1.4	0.9	1.2	-0.3	0.8	0.1
Age at last live birth	0.5	0.7	2.1	0.3	0.4	1.4	0.7	0.7
Qualifications: nursing, teaching	0.5	0.8	1.4	-1.0	-1.2	-0.2	-1.1	-0.7
Commuting to job workplace: Walk	0.5	0.5	1.6	-0.4	-0.5	-0.5	-0.5	-1.3
Financial situation satisfaction	0.5	0.6	2.4	-0.4	-0.5	-1.6	-0.5	-0.3
Medication: Bendroflumethiazide	0.5	0.8	2.4	0.6	0.5	1.5	0.9	0.5
Cholesterol lowering medication	0.5	0.8	1.2	1.1	1.1	0.8	0.9	0.1
Heart disease (siblings)	0.5	0.6	1.1	0.7	0.8	-0.1	1.0	0.9
Depression (Nagel 2018)	0.4	0.7	1.1	-0.8	-0.8	-0.9	-1.1	-0.4
Rheumatoid Arthritis	0.4	0.5	0.9	-0.8	-1.0	-0.9	-0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	-0.1	0.1	-1.2	-0.4	-0.9
Angina	0.4	0.6	2.4	-0.4	-0.2	-1.6	-0.4	-0.0
Pack years adult smoking proportion	0.4	0.6	1.1	-0.8	-1.0	-0.5	-0.2	-1.0
Townsend deprivation index at recruitment	0.4	0.5	1.4	0.8	0.6	-0.1	0.5	-1.2
Relative age voice broke	0.4	0.7	2.3	-0.5	-0.1	-0.6	-0.6	-1.5
Age when periods started (menarche)	0.4	1.0	1.4	1.1	0.9	1.2	0.9	1.0
Waist circumference	0.4	1.4	4.8	-0.5	-0.5	-2.2	-0.6	-1.3
Hair/balding pattern: Pattern 2	0.4	0.6	1.3	-0.4	-0.6	-0.9	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	-0.6	-1.2	-1.5	-1.3	-1.2
Pulse rate	0.4	0.7	1.6	0.5	0.4	1.3	0.9	1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.1	-1.0	-1.4	-0.7	-0.7	-0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.0	-1.0	-0.8	-0.3	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.4	-0.7	-1.0	-1.5	-1.3	-1.2
Breastfed as a baby	0.4	0.5	0.8	-0.6	-0.9	-0.9	-0.9	-0.3
Loud music exposure frequency	0.4	0.4	0.6	0.5	0.5	0.5	0.8	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	0.5	0.5	0.5	0.9	0.9
Arm fat-free mass (right)	0.4	1.8	3.1	1.8	1.6	0.3	1.6	1.0
Comparative body size at age 10	0.4	1.0	2.6	1.1	1.0	-0.4	0.1	-1.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	-0.7	-0.5	-0.0	-1.3	-1.1
Medication: Allopurinol	0.4	0.6	1.3	-0.4	-0.1	-0.9	-0.8	-1.1
Whole body fat mass	0.4	1.6	3.5	-0.7	-0.6	-1.8	-0.8	-1.9
Arm predicted mass (right)	0.4	2.0	3.8	1.9	1.7	0.3	1.6	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.7	-0.7	-0.5	-0.8	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.0	1.0	1.0	0.4	1.0	-0.1
Mineral and other dietary supplements	0.4	0.5	1.1	1.0	0.8	0.6	0.5	0.2
Asthma (self-reported)	0.4	0.8	1.4	-1.1	-1.2	-0.7	-0.7	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.6	2.0	-0.5	-0.3	-1.4	-0.5	0.5
Medication: Atorvastatin	0.4	0.6	1.2	-0.6	-1.0	-1.1	-0.4	-0.0
Myopia	0.4	0.6	1.0	1.0	0.9	0.8	0.4	0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	0.9	0.7	0.7	0.4	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.7	0.9	0.5	0.6	-0.1
Neuroticism (2016)	0.3	0.4	0.8	-0.7	-0.9	0.2	-0.4	0.6
Triglycerides	0.3	0.4	0.6	-0.7	-0.8	-0.4	-0.6	-0.7
Heel T-Score	0.3	2.7	8.0	-0.5	-0.6	-1.7	-1.3	-2.8
Systolic blood pressure, automated reading	0.3	0.9	1.5	-1.2	-1.1	-1.1	-0.6	-0.6
Fed-up feelings	0.3	0.6	1.0	-0.7	-1.0	-0.8	-0.7	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	-0.8	-0.4	-0.7	0.0	0.8
Trunk fat mass	0.3	1.2	3.2	-0.4	-0.3	-1.5	-0.5	-1.8
Mouth/teeth dental problems	0.3	0.4	1.1	-0.5	-0.7	-1.0	-0.2	0.5
Illnesses of siblings	0.3	0.4	1.4	-0.3	-0.4	0.6	-0.3	1.2
Arm fat percentage (right)	0.3	1.1	3.1	-0.4	-0.2	-1.4	-0.6	-1.8
Falls in the last year	0.3	0.4	0.5	-0.6	-0.7	-0.7	-0.6	-0.5
Noisy workplace	0.3	0.3	0.9	0.6	0.6	0.4	0.9	0.0
Birth weight of first child	0.3	0.6	0.8	-0.8	-0.9	-0.7	-0.7	-0.6
Pulse wave reflection index	0.3	0.4	0.9	-0.9	-0.6	-0.4	-0.6	0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.6	0.6	0.8	0.7	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	-0.6	-0.6	-1.1	-0.3	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.4	-0.5	0.6	-0.3	1.0
Emphysema/chronic bronchitis	0.3	0.3	1.3	-0.1	0.1	1.1	-0.0	-0.7
Angina (self-reported)	0.3	0.4	1.8	-0.3	-0.0	-1.3	-0.2	0.3
Leg pain on walking	0.3	0.4	0.7	-0.8	-0.8	-0.8	-0.5	-0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	-0.3	-0.1	-1.2	-0.4	-0.2
Arm fat percentage (left)	0.3	1.1	3.5	-0.2	-0.0	-1.3	-0.5	-1.9
Back pain experienced in last month	0.3	0.4	1.0	-0.6	-0.3	-0.5	-1.0	-0.4
Wears glasses or contact lenses	0.3	0.4	1.0	-0.8	-1.0	-0.3	-0.4	0.1
Ever taken oral contraceptive pill	0.3	0.3	0.4	-0.4	-0.6	-0.6	-0.3	0.7
Hearing aid user	0.3	0.3	0.9	-0.2	-0.2	-0.9	-0.4	-0.6
Ever smoked	0.3	0.5	1.0	-0.7	-0.5	-0.3	-1.0	-0.7
Arm fat-free mass (left)	0.3	1.3	2.3	1.5	1.3	-0.0	1.4	0.8
Age started oral contraceptive pill	0.3	0.3	0.6	-0.5	-0.5	-0.8	-0.2	0.6
Unable to work because of sickness or disability	0.3	0.4	0.8	0.5	0.6	-0.2	0.9	0.9
Depressed Affect (Nagel 2018)	0.2	0.5	1.0	-0.9	-1.0	-0.4	-0.7	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.1	-0.1	-0.3	0.5	0.4	1.4
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.7	0.5	-0.0	0.4	0.3
Irritable Bowel Disease (IBD)	0.2	0.6	1.6	0.5	0.5	1.3	0.8	0.3
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.7	-0.7	0.5	-0.4	-0.4
HbA1C	0.2	0.3	0.5	0.7	-0.1	-0.2	-0.6	-0.6
Ulcerative Colitis	0.2	0.2	0.5	-0.5	-0.5	0.7	0.1	0.3
Height	0.2	4.6	6.2	2.1	2.1	2.0	2.0	2.5
Allergy or Eczema	0.2	0.5	1.6	0.5	-0.1	1.3	0.8	0.3
Tanning	0.2	2.5	3.5	1.7	1.9	1.8	1.2	1.2
Average weekly spirits intake	0.2	0.3	0.9	0.4	0.4	0.2	0.1	1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	0.7	0.4	0.2	0.9	0.4
Supplements: Zinc	0.2	0.2	0.5	-0.4	-0.7	0.1	0.2	0.7
Taking other prescription medications	0.2	0.4	1.0	-0.8	-1.0	-0.0	-0.0	0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-0.2	-0.1	-0.4	-0.9	0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.4	-0.6	-0.2	-0.3	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.5	0.3	-0.2	1.2	0.7	-0.0
Number of incorrect matches in round	0.2	0.3	1.1	-0.2	-0.0	-1.1	-0.3	0.4
Nervous feelings	0.2	0.4	0.8	-0.9	-0.7	0.0	-0.7	-0.6
Had menopause	0.2	0.3	0.9	0.4	0.5	0.1	1.0	-0.2
Qualifications: None of the above	0.2	0.4	1.0	0.6	1.0	0.4	0.7	-0.5
Allergy	0.2	0.5	1.6	-0.4	-0.0	-1.3	-0.8	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.3	-0.7	0.1	0.3	0.6
Fluid intelligence score	0.2	0.3	1.0	0.2	0.1	1.0	-0.0	0.7
Neuroticism score	0.2	0.4	0.9	0.2	-0.0	1.0	0.5	1.0
Hip circumference	0.2	1.0	1.8	1.3	1.3	-0.1	1.1	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.8	0.5	-0.0	0.7	-0.1
Medication: Cholesterol lowering	0.2	0.3	0.6	0.1	0.4	-0.2	0.8	0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	-0.2	0.0	-0.4	0.1	0.9
Length of working week for main job	0.2	0.2	0.5	0.0	-0.3	-0.7	-0.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.6	0.6	0.7	0.2	0.2
Gout (self-reported)	0.2	0.2	0.5	-0.3	-0.1	-0.7	-0.5	-0.4
Medication: Amlodipine	0.2	0.3	0.9	-0.3	-0.4	-0.6	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.8	1.2	-0.6	-0.8	-1.1	-1.1	-0.9
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.6	0.8	0.5	0.4	0.3
Pulse wave peak to peak time	0.2	0.2	0.6	0.3	0.0	0.6	-0.0	-0.8
Medication: Ibuprofen	0.2	0.2	1.1	-0.0	-0.1	-0.2	0.3	1.0
Medication: Omeprazole	0.2	0.2	0.7	-0.2	-0.3	-0.8	-0.3	-0.3
Alcohol intake frequency.	0.2	0.6	1.2	0.9	1.1	0.4	0.8	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.5	0.1	0.3	0.4	0.6
Friendships satisfaction	0.2	0.2	0.4	-0.5	-0.6	-0.0	-0.1	-0.6
Arm fat mass (left)	0.2	0.7	2.1	0.2	0.2	-1.2	-0.1	-1.5
Average weekly champagne plus white wine intake	0.2	0.3	0.5	-0.7	-0.7	0.4	-0.5	-0.2
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.7	0.5	0.5	0.4	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.2	-0.2	-0.6	-0.1	0.8
Pack years of smoking	0.2	0.2	0.8	-0.4	-0.4	-0.2	0.2	-0.9
Arm predicted mass (left)	0.2	1.1	2.1	1.5	1.3	-0.1	1.2	0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.7	-0.8	-0.2	-0.5	0.6
Major Depression (MDD)	0.1	0.2	0.7	-0.2	-0.3	-0.3	-0.8	0.1
Reaction Time	0.1	0.2	0.8	-0.2	-0.0	0.9	0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.5	-0.5	0.1	-0.3	0.5
Crohns Disease (2012)	0.1	0.2	0.4	0.0	-0.4	0.6	0.4	0.3
HDL Cholesterol	0.1	0.2	0.5	-0.7	-0.6	-0.1	-0.3	0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.0	0.1	0.5	-0.4	-0.3
BMI	0.1	0.8	1.4	1.1	1.2	0.2	0.8	-0.9
Respiratory disease	0.1	0.3	0.6	-0.8	-0.8	-0.4	-0.4	-0.3
Lung FVC	0.1	0.8	1.9	0.1	0.3	-1.2	-0.6	-1.4
Neuroticism	0.1	0.2	0.6	-0.5	-0.5	0.2	-0.0	0.8
Number of treatments/medications taken	0.1	0.1	0.3	-0.3	-0.2	0.1	0.5	0.3
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.4	0.6	-0.1	-0.0	-0.4
Relative age of first facial hair	0.1	0.2	0.4	0.1	0.3	0.2	-0.4	-0.7
Diabetes (mother)	0.1	0.1	0.4	-0.0	0.1	-0.1	-0.2	-0.6
Average weekly fortified wine intake	0.1	0.2	0.5	0.0	-0.0	-0.7	-0.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.6	0.3	0.2	0.3	0.0
High blood pressure	0.1	0.3	0.7	0.6	0.8	0.4	0.6	0.1
Supplements: Glucosamine	0.1	0.1	0.2	-0.4	-0.4	0.4	0.2	0.1
Sitting height	0.1	0.7	1.7	1.0	0.4	0.6	0.6	1.3
Body mass index (BMI)	0.1	0.6	1.1	0.7	0.9	-0.6	0.5	-1.0
Past tobacco smoking	0.1	0.1	0.3	0.4	-0.1	-0.2	0.5	0.2
Alcohol usually taken with meals	0.1	0.2	0.5	0.2	0.2	0.7	-0.1	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.0	-0.2	-0.6	-0.5	-0.1
Heart attack	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.3	0.4
Weight	0.1	0.7	1.3	1.1	1.1	-0.4	0.8	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.4	0.5	0.6	0.5	-0.3
Worrier / anxious feelings	0.1	0.3	0.7	-0.1	-0.1	0.6	0.5	0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.2	-0.2	-0.1	0.3	0.6
Happiness	0.1	0.1	0.2	-0.1	-0.4	0.5	-0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	0.2	0.2	-0.0	0.3	0.7
Lung cancer (father)	0.1	0.1	0.3	-0.2	-0.1	0.5	0.1	0.5
Arm fat mass (right)	0.1	0.5	1.4	0.4	0.4	-0.9	0.1	-1.2
Standing height	0.1	1.0	2.7	1.1	0.5	0.6	0.8	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.5	0.6	0.3	0.1	0.2
Hair/balding pattern: Pattern 4	0.1	0.1	0.2	-0.4	-0.2	-0.3	-0.5	-0.5
Medication: Paracetamol	0.1	0.2	1.0	0.1	0.0	-1.0	0.0	-0.2
Worry too long after embarrassment	0.1	0.1	0.3	0.1	0.0	0.5	0.4	0.6
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.2	-0.0	-0.5	0.4	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.5	-0.0	-0.3	0.0	-0.2	0.7
Migraine (self-reported)	0.1	0.1	0.5	0.2	0.4	0.1	0.7	-0.2
Mean time to correctly identify matches	0.1	0.3	0.8	-0.5	-0.1	0.9	0.3	0.5
Overall health rating	0.1	0.2	0.5	0.5	0.2	-0.1	0.7	0.3
Hypertension (Self-reported)	0.1	0.4	0.7	0.7	0.8	0.5	0.8	0.2
Smoking status: Previous	0.1	0.2	0.7	-0.1	0.2	0.8	-0.0	0.3
Mood swings	0.1	0.3	0.7	0.1	0.1	0.7	0.2	0.8
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.0	0.2	0.0	0.3	0.5
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.0	0.2	0.5	-0.4	-0.3
Guilty feelings	0.1	0.2	0.4	-0.5	-0.6	-0.4	-0.6	0.1
Mother’s age at death	0.1	0.2	0.4	-0.6	-0.2	0.6	0.1	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.5	0.5	-0.1	-0.0	-0.4
High cholesterol (Self-reported)	0.1	0.3	0.7	0.4	0.5	-0.2	0.9	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.1	-0.6	0.1	0.2	0.4
Risk taking	0.1	0.1	0.3	0.1	0.1	0.6	0.2	0.0
Ever depressed for a whole week	0.1	0.2	0.4	0.4	0.6	0.1	0.2	0.4
Commuting to job workplace: Cycle	0.1	0.2	0.5	-0.1	-0.1	0.4	-0.3	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	-0.4	0.1	-0.3	0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.1	0.3	0.1	0.2	0.0	-0.2
Blood Red Count	0.0	0.0	0.1	0.2	-0.1	0.2	0.3	-0.2
Cardiovascular Disease	0.0	0.1	0.2	-0.4	-0.4	0.0	-0.1	-0.3
Hair Pigment	0.0	0.1	0.3	-0.5	-0.2	0.3	-0.0	0.4
Forced vital capacity (FVC)	0.0	0.2	0.4	-0.1	-0.4	-0.6	-0.5	-0.2
Number of live births	0.0	0.0	0.1	0.1	0.3	0.2	0.1	-0.0
Prospective memory result	0.0	0.0	0.1	-0.2	0.0	0.4	0.2	-0.2
Health satisfaction	0.0	0.1	0.1	-0.1	-0.3	-0.3	0.2	-0.2
Neck or shoulder pain in last month	0.0	0.0	0.0	0.2	0.1	-0.2	0.2	0.1
Medication: Blood pressure	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.1	-0.2
Comparative height size at age 10	0.0	0.2	0.3	-0.4	-0.6	-0.3	-0.4	0.5
Family relationship satisfaction	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.2	0.1
Loneliness, isolation	0.0	0.0	0.0	0.1	0.2	-0.1	0.0	0.0
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.0	0.1
Miserableness	0.0	0.1	0.2	-0.2	-0.4	-0.3	-0.2	-0.1
Irritability	0.0	0.1	0.1	0.3	0.3	0.3	0.1	0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.2	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.2	-0.3	0.3	-0.2	0.4
Pain experienced in last month	0.0	0.1	0.3	0.0	-0.0	0.0	0.5	0.3

Hub : Genes

STAB2

Models

Trait associations