Hub : Genes

STAU2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2950	0.0890	0.0006	-0.005	NA	0.007	NA	0.006	0.4900	NA	0.19000	NA	0.2100
2	GTEx	Heart Left Ventricle	0.1467	0.0558	0.0041	-0.002	NA	-0.004	NA	-0.005	0.4200	NA	0.61000	NA	0.8100
3	GTEx	Nerve Tibial	0.0975	0.0448	0.0084	0.019	NA	0.000	NA	0.010	0.0160	NA	0.32000	NA	0.0570
4	NTR	Blood	0.0240	0.0100	0.0075	-0.001	0.002	0.001	0.002	0.000	0.6900	0.05000	0.12000	0.056	0.2400
5	TCGA	Pancreatic Adenocarcinoma	0.1210	0.0600	0.0054	0.039	0.068	0.082	NA	0.048	0.0091	0.00085	0.00026	NA	0.0045

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	4.2	0.4	0.7	-2.0	-0.0	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.8	6.2	0.1	1.5	-2.5	-0.6	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	2.2	1.5	0.3	0.6	-0.1	1.0
Depression (Nagel 2018)	0.6	0.9	2.7	1.6	0.9	-0.2	-0.9	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.0	0.2	-0.5	-1.0	-1.4	-0.6
Neuroticism (Nagel 2018)	0.9	2.2	5.7	1.6	0.1	1.4	0.8	2.4
Schizophrenia (2018)	0.5	1.0	2.4	-0.3	1.4	-1.5	-0.8	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.5	0.4	-0.3	0.7	0.6
Worry (Nagel 2018)	0.8	1.7	4.7	0.8	-0.2	1.7	0.2	2.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.7	0.8	-1.0	1.3	-0.5	0.8
Alzheimer’s Disease (in father)	0.6	0.7	1.4	1.2	0.3	0.3	1.2	0.7
Alzheimer’s Disease (including proxy)	1.0	1.4	3.4	1.8	-0.5	1.5	0.5	1.0
Crohns Disease (2017)	1.3	2.9	5.9	2.2	1.1	1.5	0.4	2.4
Irritable Bowel Disease (IBD)	0.7	1.7	4.2	1.4	1.2	0.7	-0.7	2.0
Ulcerative Colitis (UC)	0.3	0.5	1.8	-0.2	0.6	-0.4	-1.4	0.5
Major Depression (MDD)	0.7	0.9	2.8	1.7	-0.3	-0.3	1.2	-0.1
Reaction Time	0.6	1.1	3.2	-0.2	0.9	-1.8	-1.3	0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.9	-0.3	-0.1	-0.2	-2.2	-0.9
Breast Cancer	1.3	3.2	8.0	-1.0	0.6	-2.8	0.7	-2.4
Ovarian Cancer	0.9	1.1	2.4	0.5	0.5	1.6	-0.8	1.4
Prostate Cancer	0.3	0.5	1.1	-0.4	-1.1	0.6	-0.6	-0.4
Age at First Birth	0.9	1.3	5.0	-1.1	-2.2	0.4	0.0	-0.3
Bipolar Disorder (2011)	2.2	2.1	4.9	-0.9	-0.5	-2.1	0.5	-2.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	0.0	1.3	0.5	0.3	0.1
Coronary Artery Disease (CAD)	0.6	0.7	1.3	-1.1	1.0	0.3	0.6	-0.9
Crohns Disease (2012)	1.2	1.9	4.3	1.6	0.6	1.5	-0.5	2.1
Mean Putamen Volume	0.3	0.3	0.8	0.3	0.2	-0.9	0.7	-0.4
Fasting Glucose	0.7	0.8	2.3	-0.4	-1.5	-0.3	-0.8	-0.9
HbA1C	2.4	2.7	9.0	1.5	-0.3	1.4	-0.3	3.0
HDL Cholesterol	0.2	0.4	0.9	0.8	-0.5	-1.0	-0.4	-0.1
LDL Cholesterol	0.2	0.4	1.8	1.3	-0.2	0.1	-0.1	-0.1
Lupus	1.1	1.6	2.8	1.7	0.6	1.6	-0.5	1.3
Neuroticism (2016)	0.9	1.3	4.2	0.4	2.0	-0.6	1.4	0.1
Primary Biliary Cirrhosis	1.1	1.6	4.3	-2.1	1.0	-0.8	-1.0	-1.1
Rheumatoid Arthritis	0.6	0.8	2.5	1.6	0.5	0.7	0.3	0.8
Schizophrenia (2014)	0.5	1.0	2.6	-0.2	1.2	-1.6	-1.0	0.0
Triglycerides	0.4	0.7	2.5	-1.6	-0.0	0.7	0.3	-0.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	1.6	1.7	0.3	-0.4	-1.4
Ulcerative Colitis	0.6	0.9	2.8	-0.7	0.2	0.1	-1.7	0.9
Blood Eosinophil Count	0.5	3.9	11.7	3.4	-1.1	2.1	-1.5	-0.2
Blood Platelet Count	0.1	0.6	1.1	-1.0	1.1	0.7	0.5	0.5
Blood Red Count	0.1	1.4	3.9	0.8	2.0	0.5	0.4	1.4
Blood White Count	0.3	2.4	7.7	2.8	1.0	1.0	-1.1	1.2
Heel T-Score	0.0	0.4	1.2	-0.1	0.8	0.1	1.1	0.1
BMI	0.7	4.2	8.6	1.4	0.5	2.9	2.9	1.4
Height	0.2	2.9	12.7	-0.7	0.5	-3.6	-0.5	-0.9
Waist Hip Ratio (WHR)	0.8	3.4	6.5	-2.3	0.4	-2.5	-1.9	-1.2
Systolic Blood Pressure	0.8	3.9	8.0	-2.8	-1.3	-2.0	-0.1	-2.4
Smoking Status	0.3	0.8	2.6	1.6	0.0	-0.9	0.7	0.0
Allergy or Eczema	0.1	0.3	0.8	-0.4	-0.7	0.9	0.4	0.5
Cardiovascular Disease	0.3	1.0	2.4	1.6	0.7	1.2	-0.4	0.5
Hypothyroidism (self reported)	0.8	1.9	4.1	-0.4	-0.5	2.0	1.5	1.6
Respiratory disease	1.9	4.3	5.9	2.4	0.7	2.2	2.2	2.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	0.5	0.9	0.9	-0.0	-0.9
Lung FEV1/FVC ratio	0.7	3.3	12.2	0.8	0.0	1.9	-0.5	3.5
Lung FVC	0.5	2.6	9.2	0.9	-0.7	0.2	1.6	-3.0
Neuroticism	0.3	0.8	2.1	1.4	0.1	-0.2	0.6	1.2
Chronotype (morning person)	0.4	1.0	2.4	-1.6	0.1	-1.1	-0.1	-1.1
Hair Pigment	0.0	0.7	1.4	-0.6	-1.2	1.0	0.3	-0.7
Tanning	0.0	0.6	1.2	1.0	0.0	0.7	0.2	1.1
Hand grip strength (left)	3.2	8.4	19.9	1.4	-1.9	4.5	2.7	3.1
Number of treatments/medications taken	4.1	7.3	15.1	3.9	0.8	3.6	0.8	2.7
Average weekly spirits intake	1.9	2.4	9.8	1.3	-0.0	-0.2	-3.1	-0.6
Sensitivity / hurt feelings	0.4	0.7	2.1	1.4	-0.3	-0.5	0.7	0.6
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.1	1.8	-0.7	0.3	-0.5	0.7
Hearing difficulty/problems: Yes	1.3	1.9	5.8	1.4	-2.4	1.2	0.4	-0.1
Relative age of first facial hair	0.2	0.4	1.7	-0.3	-0.1	0.2	-1.3	-0.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.6	1.9	0.1	1.6	0.6	1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.4	-0.0	1.2	-0.1	0.8	1.1
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	-0.8	-0.1	-0.6	1.2	-0.4
Systolic blood pressure, automated reading	0.8	2.3	7.4	-2.7	-1.1	-0.7	0.9	-1.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	0.6	1.4	0.5	-0.0	1.4
Angina	3.6	4.7	21.4	4.6	0.8	0.3	0.7	-0.9
Medication for hormone replacement therapy	0.8	0.9	2.4	-1.6	-1.1	0.3	0.4	0.8
Vitamin and mineral supplements	1.2	1.6	4.8	-0.1	-1.3	0.1	-2.2	-1.2
Supplements: Zinc	0.7	0.7	1.2	0.6	1.1	-0.9	-1.1	0.3
Medication: Co-codamol	1.1	1.3	4.9	2.2	0.8	-0.1	0.4	-0.8
Medication: Metformin	0.7	1.0	2.1	1.1	0.8	1.4	-0.7	-0.7
Diabetes (father)	0.2	0.2	0.4	-0.5	0.2	0.6	-0.7	-0.1
Diabetes (mother)	0.5	0.6	1.3	-0.9	0.7	0.6	-1.2	0.3
Severe depression (siblings)	0.7	0.7	1.8	0.1	-0.3	0.4	-1.3	1.3
Pack years adult smoking proportion	0.6	0.8	1.5	1.1	-1.1	0.3	1.2	0.6
Impedance of leg (right)	3.5	17.2	48.2	-1.7	2.0	-6.9	-3.7	-4.2
Leg fat-free mass (left)	0.6	3.4	8.2	1.6	-0.8	2.9	2.1	0.9
Trunk fat percentage	0.3	1.2	3.2	0.3	1.8	-0.7	1.1	-1.1
Hand grip strength (right)	2.8	7.6	20.6	1.8	-0.7	4.5	1.9	3.2
Townsend deprivation index at recruitment	1.0	1.4	3.2	-0.9	-1.6	-1.8	0.6	-0.4
Current tobacco smoking	0.7	1.2	3.1	1.8	-1.1	0.5	0.6	0.8
Average weekly fortified wine intake	0.7	0.8	1.2	-1.0	-0.6	1.1	0.6	0.9
Maternal smoking around birth	1.4	2.1	4.0	1.9	-2.0	0.1	1.7	-0.2
Fed-up feelings	0.6	1.1	2.6	1.6	-1.0	0.7	0.4	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.2	1.8	-0.3	1.2	0.5	0.9
Relative age voice broke	0.6	0.9	2.9	-0.2	0.4	1.0	-1.7	0.7
Taking other prescription medications	2.4	3.7	8.5	2.9	0.8	2.4	1.0	1.5
Age when periods started (menarche)	0.6	1.4	1.9	1.3	-1.4	1.2	0.6	1.1
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.8	-2.2	0.2	-1.7	0.5	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	0.2	0.3	-0.5	0.9	0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	0.2	-1.9	1.3	0.1	0.9
Qualifications: CSEs or equivalent	0.7	0.9	2.6	-1.6	-1.2	0.5	0.2	-0.3
Serious illness, injury or assault to yourself	0.9	1.1	4.1	2.0	0.6	0.8	0.2	-0.5
High blood pressure	0.1	0.4	1.0	0.8	0.1	0.4	-1.0	-0.0
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	-0.6	-0.1	0.9	-0.0	-0.0
Multivitamins +/- minerals	0.7	0.8	1.5	-1.1	0.8	-0.7	1.2	0.5
Stomach or abdominal pain in last month	0.7	0.8	1.8	-1.2	-1.3	0.6	0.8	-0.2
Supplements: Glucosamine	0.5	0.7	1.5	1.1	0.7	-1.2	0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	6.5	-1.6	0.2	-0.6	-2.5	-0.8
Medication: Atenolol	0.3	0.3	1.1	1.0	0.5	-0.3	-0.3	-0.3
Medication: Levothyroxine sodium	0.5	0.9	1.6	0.2	-0.3	1.1	1.2	1.2
Sitting height	0.1	0.9	2.2	-0.2	-0.6	-1.5	-0.4	-1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	1.0	-0.1	-1.0	1.1	0.4
High blood pressure (mother)	0.2	0.3	1.1	-0.5	-0.2	-1.0	-0.1	-0.1
Body mass index (BMI)	0.9	3.7	8.3	1.4	0.5	2.9	2.8	0.6
Impedance of leg (left)	2.8	13.6	39.9	-1.4	1.9	-6.3	-3.3	-3.4
Leg predicted mass (left)	0.6	3.2	7.9	1.6	-0.8	2.8	2.1	0.8
Trunk fat mass	0.2	0.9	1.9	0.5	1.4	-0.3	1.1	-1.0
Waist circumference	0.2	0.7	1.5	0.6	1.2	0.3	0.6	-1.1
Number of incorrect matches in round	0.9	1.5	2.9	1.7	1.6	-0.3	-1.1	0.8
Past tobacco smoking	1.1	1.9	4.8	-2.2	-1.6	0.2	-1.4	-0.6
Alcohol usually taken with meals	1.0	1.7	4.1	-1.9	-0.3	0.4	2.0	0.6
Nervous feelings	0.7	1.3	2.7	-0.1	-0.5	1.2	1.4	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.5	1.9	-0.8	-0.0	0.9	0.8
Hearing difficulty/problems with background noise	1.9	3.0	5.0	1.6	-2.2	1.5	2.1	1.1
Hair/balding pattern: Pattern 2	1.8	2.3	6.8	-0.4	0.7	1.0	2.6	1.7
Had menopause	1.2	1.5	2.9	1.4	0.7	-1.7	-0.4	-1.4
Had other major operations	1.3	1.5	2.5	-0.0	1.5	-0.9	1.5	-1.6
Forced vital capacity (FVC)	0.5	1.9	7.4	-0.4	-0.7	-1.2	-0.3	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.2	-1.0	-0.4	0.3	1.1	0.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.5	-1.8	-0.7	0.3	1.9	-0.2
Qualifications: None of the above	1.1	2.3	6.1	2.5	-0.4	0.2	1.4	1.8
Financial difficulties in last 2 years	0.7	0.9	3.0	1.0	-1.7	0.5	0.3	-0.3
Mouth/teeth dental problems	1.8	2.7	8.2	-0.6	0.6	-2.1	-0.4	-2.9
Heart attack	3.4	4.4	16.6	4.1	0.8	2.0	-0.3	0.7
Allergy	0.7	1.6	3.4	-1.4	0.3	-1.4	-1.9	-0.8
Pain all over the body in last month	1.2	1.3	5.7	2.4	-0.2	0.8	0.4	0.2
Diabetes (self-reported)	0.2	0.4	1.0	-0.5	0.7	0.1	1.0	-0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.0	-0.4	0.7	0.7	0.4	1.4
Medication: Ramipril	0.2	0.3	0.6	-0.8	0.1	-0.4	0.7	-0.2
Medication: Simvastatin	0.4	0.7	1.5	1.1	0.7	1.2	-0.3	0.3
Fluid intelligence score	0.9	1.9	4.0	-1.1	1.1	-1.1	-2.0	-1.4
Illnesses of siblings	0.3	0.4	1.1	0.2	-0.1	1.1	0.3	1.0
Neuroticism score	0.3	0.6	1.0	1.0	-0.9	0.4	0.6	0.8
Weight	0.3	1.4	3.5	1.1	0.4	1.3	1.9	-0.1
Impedance of arm (right)	1.7	7.7	19.8	-1.1	1.7	-4.5	-3.4	-1.8
Arm fat percentage (right)	0.3	1.0	2.2	0.8	1.5	1.0	1.2	0.1
Trunk fat-free mass	0.2	1.0	2.0	0.8	-1.1	1.4	1.1	0.4
Hip circumference	0.2	1.1	1.7	1.2	0.8	1.0	0.7	-1.3
Time employed in main current job	0.2	0.2	0.4	-0.4	0.2	-0.7	0.4	0.3
Alcohol intake versus 10 years previously	0.7	1.0	3.2	1.8	0.1	-1.0	-0.2	-0.8
Father’s age at death	0.6	0.8	1.3	-1.0	-0.5	0.6	-0.9	1.1
Worrier / anxious feelings	0.5	1.0	2.2	1.5	-0.5	1.4	0.1	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.7	6.3	2.5	-1.3	1.8	0.8	1.3
Falls in the last year	0.6	0.9	3.0	1.7	0.7	-0.2	0.5	-0.8
Hair/balding pattern: Pattern 3	0.9	1.4	3.3	0.6	-1.8	1.7	-0.6	0.2
Number of live births	1.6	2.3	8.1	0.7	0.8	0.2	1.5	2.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.8	-0.9	-0.5	-0.5	-0.2	-1.3
Pulse rate	0.7	1.2	2.3	0.1	0.7	-1.5	-1.0	-1.5
Happiness	0.1	0.2	0.6	0.3	-0.7	0.1	-0.4	-0.2
Noisy workplace	1.2	1.5	2.5	1.2	-0.2	1.1	1.5	1.6
Qualifications: A levels/AS levels or equivalent	1.4	3.2	8.1	-1.1	-2.1	2.9	-0.9	1.2
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	6.7	-2.1	0.9	-2.6	1.1	-1.7
Mouth/teeth dental problems: Dentures	1.2	2.0	6.1	-0.2	-0.2	2.0	-0.0	2.5
Asthma	1.3	2.6	5.4	1.8	0.2	1.7	2.3	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	-0.3	-0.6	0.5	-0.0	1.1
Medication: Cholesterol lowering	1.9	3.0	11.3	3.4	0.1	1.7	0.1	0.9
Depression (self-reported)	0.7	0.8	1.6	-0.4	1.3	-0.4	-1.0	-1.1
Medication: Lansoprazole	0.7	0.8	2.6	1.6	0.7	0.7	0.6	0.6
Prospective memory result	1.3	1.6	5.7	1.3	-0.2	0.8	-0.2	2.4
Lung cancer (father)	0.5	0.6	2.7	-0.4	0.2	0.3	1.6	-0.3
Illnesses of mother	0.5	0.6	1.5	0.8	0.8	0.6	-1.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.2	-0.6	-0.3	-1.2	-1.0	-1.8
Pulse wave Arterial Stiffness index	1.0	1.2	5.4	-0.2	0.2	0.2	0.5	2.3
Impedance of arm (left)	1.5	7.1	18.6	-1.4	1.4	-4.3	-3.2	-1.6
Arm fat mass (right)	0.3	1.4	2.8	0.9	0.8	1.6	1.7	0.0
Trunk predicted mass	0.2	1.0	1.8	0.8	-1.0	1.3	1.1	0.4
Standing height	0.3	3.0	9.2	-0.3	-0.1	-3.0	-1.9	-1.4
Length of working week for main job	0.6	0.6	1.5	0.4	1.2	-0.5	-0.7	-0.9
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.2	-0.4	-0.9	0.6	-0.3
Breastfed as a baby	2.3	2.9	7.4	-0.1	-0.4	-1.8	-2.7	-1.8
Tense / ‘highly strung’	0.3	0.4	1.1	-0.3	-1.1	0.3	-0.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.5	0.6	-0.6	1.1	2.1	0.7
Hair/balding pattern: Pattern 4	0.6	1.3	3.9	0.5	-0.0	-0.3	-2.0	-1.6
Birth weight of first child	1.2	2.3	7.9	-1.1	-0.3	0.8	2.8	1.2
Peak expiratory flow (PEF)	0.2	0.4	1.4	0.3	0.2	-0.0	-0.6	1.2
Pulse wave reflection index	2.3	2.8	8.4	0.5	1.1	1.9	0.9	2.9
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.7	1.3	-0.9	1.3	0.1	0.8
Loud music exposure frequency	1.7	1.8	3.5	1.7	-0.9	1.9	-0.6	1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.7	-0.6	-0.3	1.3	-1.6	-0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.6	-0.6	0.1	-0.4	-0.8
Blood clot in the leg (DVT)	1.7	2.1	3.9	1.2	-0.5	1.5	1.7	2.0
Medication: Paracetamol	1.2	1.9	5.8	2.4	0.1	1.0	0.1	1.7
Headache pain in last month	0.5	0.9	2.0	0.2	-1.3	0.5	-0.9	1.4
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	9.0	-3.0	-0.0	-2.1	0.6	-1.8
Glaucoma (self-reported)	0.8	0.9	2.5	-0.7	-0.2	1.2	1.6	0.1
Gout (self-reported)	0.6	0.8	1.9	0.4	-0.2	1.4	0.3	1.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.4	0.5	-0.1	1.9	1.2	1.6
Medication: Amlodipine	0.5	0.7	0.9	-0.9	-0.8	0.6	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	1.1	1.3	2.3	1.2	1.5	0.4	1.1	-1.3
Birth weight	0.4	0.9	2.6	0.7	-0.2	1.0	0.7	1.6
Chronic bronchitis/emphysema (mother)	2.5	3.0	5.3	1.0	-1.4	1.9	2.3	1.8
High blood pressure (siblings)	0.3	0.4	1.2	-1.1	-0.2	-0.4	-0.3	-0.8
Forced vital capacity (FVC), Best measure	0.7	2.5	8.3	-0.3	-0.9	-1.6	-0.8	-2.9
Body fat percentage	0.4	1.5	3.5	0.6	1.9	-0.8	1.0	-1.4
Leg fat percentage (right)	0.8	2.8	6.4	0.4	2.5	-1.4	1.0	-2.1
Arm fat-free mass (right)	0.3	1.7	3.7	0.8	-1.1	1.6	1.9	0.1
Exposure to tobacco smoke outside home	0.7	1.0	2.3	0.5	0.2	-1.4	0.2	-1.5
Comparative body size at age 10	0.1	0.3	1.2	-0.4	-1.1	0.4	-0.4	-0.3
Number of full brothers	0.5	0.6	1.7	0.1	0.7	-0.9	-1.3	-0.2
Worry too long after embarrassment	0.4	0.7	1.1	0.5	-1.0	0.5	0.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.1	1.4	0.9	-0.2	1.4	0.3
Wheeze or whistling in the chest in last year	2.5	4.4	11.4	1.8	-0.7	1.8	3.4	1.9
Number of children fathered	0.1	0.1	0.4	0.4	-0.1	0.2	-0.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	4.7	0.5	0.7	0.1	0.4	2.2
Age at first live birth	1.3	2.2	9.7	-3.1	-0.3	-0.8	-0.4	-0.8
Pulse wave peak to peak time	1.0	1.2	5.0	0.2	-0.3	-0.4	-0.8	-2.2
Health satisfaction	3.3	4.3	10.8	3.3	-0.8	2.7	-0.3	1.6
Shortness of breath walking on level ground	1.1	1.3	4.6	2.1	0.6	1.0	-0.3	0.5
Qualifications: College or University degree	0.6	2.0	5.9	-2.4	1.0	-1.0	-1.2	-1.0
Eye problems/disorders: None of the above	2.4	2.8	8.1	-1.2	-0.9	-2.9	-0.5	-1.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	-1.2	-0.9	-0.2	0.4	0.5
Emphysema/chronic bronchitis	1.1	1.2	4.0	1.1	0.5	-0.2	2.0	-0.8
Medication for pain relief, constipation, heartburn	2.2	3.8	11.4	-3.4	0.1	-1.8	-1.2	-1.7
Neck or shoulder pain in last month	1.4	2.0	4.8	0.9	-1.4	2.2	0.2	1.5
Medication: Blood pressure	0.8	1.4	2.4	1.2	-0.3	1.5	-1.3	1.1
Angina (self-reported)	3.5	4.6	21.3	4.6	0.8	0.3	0.4	-1.0
Migraine (self-reported)	0.5	0.7	1.6	-1.3	-0.7	-0.7	-0.3	-0.7
Medication: Ibuprofen	0.9	1.1	2.4	0.4	-1.0	1.6	0.0	1.4
Medication: Allopurinol	1.5	1.9	4.5	1.0	0.3	1.9	-0.6	2.1
Medication: Omeprazole	1.5	1.8	3.6	1.3	-0.6	1.9	0.7	1.6
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.8	0.1	0.1	0.1	-0.5
Mean time to correctly identify matches	1.2	2.4	7.8	0.8	1.5	-2.8	-1.0	-0.4
Heart disease (mother)	0.6	0.7	2.1	-0.4	-0.8	-0.8	-0.2	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.5	-1.2	-0.0	-0.3	-0.3	0.2
Whole body fat mass	0.2	0.8	1.5	0.7	1.1	0.3	1.2	-0.8
Leg fat mass (right)	0.3	1.3	2.3	1.1	1.4	0.1	1.5	-1.0
Arm predicted mass (right)	0.3	1.5	3.0	0.9	-1.1	1.7	1.7	0.3
Pulse rate, automated reading	0.3	1.0	1.4	-1.2	0.9	-1.1	0.4	-1.2
Alcohol intake frequency.	0.5	1.1	3.5	1.9	0.6	0.8	-0.4	0.8
Comparative height size at age 10	0.4	2.1	7.4	0.3	0.4	-2.7	-0.6	-1.5
Number of full sisters	0.8	0.9	2.7	-0.3	-0.9	0.7	0.8	1.7
Suffer from ‘nerves’	0.1	0.2	0.8	-0.2	-0.3	-0.1	-0.5	0.9
Overall health rating	2.1	4.6	9.5	3.1	-1.8	1.9	1.8	1.8
Chest pain or discomfort	1.8	2.6	11.3	3.4	-0.3	0.8	0.8	-0.2
Had major operations	1.3	1.6	5.4	2.3	0.8	1.1	-0.1	0.7
Age at last live birth	0.4	0.6	2.0	-1.4	-0.6	-0.6	-0.5	-0.3
Family relationship satisfaction	1.1	1.4	2.4	1.4	0.5	-1.6	-1.4	-0.6
Leg pain on walking	0.8	1.0	3.2	1.8	-1.1	-0.1	0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.6	-1.0	1.2	-1.3	0.3	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.0	0.6	-0.9	1.0	0.6	0.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	4.2	-2.0	0.4	-0.3	-0.7	-0.6
Medication: Aspirin	2.5	3.2	14.7	3.8	0.4	0.6	0.9	0.4
Supplements: Vitamin C	0.9	1.0	3.1	1.8	1.3	-0.5	-0.1	0.1
Knee pain experienced in last month	0.6	0.9	2.2	0.3	-1.2	1.5	0.6	0.6
Hypertension (Self-reported)	0.2	0.5	1.9	0.5	-0.3	0.0	-1.4	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	0.7	-0.1	0.0	-0.1	0.6
Illnesses of father: Heart disease	2.2	3.1	4.7	0.9	-2.2	2.2	-1.1	2.0
Illnesses of siblings: Diabetes	0.6	0.8	2.8	0.2	-0.8	1.7	0.6	0.3
Smoking status: Previous	0.6	0.9	1.7	1.2	1.3	-0.9	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.9	-0.5	-1.4	-1.3	-1.6	-2.2
Whole body fat-free mass	0.4	2.2	5.0	1.2	-1.0	2.2	1.7	0.8
Leg fat-free mass (right)	0.8	4.3	11.3	1.5	-1.0	3.4	2.3	1.4
Arm fat percentage (left)	0.2	0.9	1.8	0.8	1.3	1.0	1.1	0.0
Average weekly red wine intake	1.8	2.6	4.9	-1.2	-1.7	2.2	-0.0	1.9
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.9	1.2	-1.5	0.2	1.2	1.7
Mood swings	0.7	1.3	2.7	1.5	0.5	0.6	0.9	1.6
Loneliness, isolation	0.3	0.4	1.7	1.3	-0.3	-0.2	0.2	0.4
Long-standing illness, disability or infirmity	3.2	4.8	10.8	2.3	-1.4	3.3	1.6	1.9
Ever had bowel cancer screening	0.4	0.4	1.3	-0.5	-0.2	0.4	-0.7	1.1
Diabetes diagnosed by doctor	0.3	0.6	1.5	-0.1	-0.3	0.8	1.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.3	-0.3	-0.4	0.5	0.7
Friendships satisfaction	1.0	1.3	2.1	0.8	0.7	-1.4	-1.1	-1.4
Qualifications: nursing, teaching	1.0	1.5	3.7	-1.5	0.2	-0.5	-1.9	-1.1
Commuting to job workplace: Walk	1.9	2.1	5.9	-0.8	0.8	-2.4	-1.4	-1.1
Eye problems/disorders: Cataract	0.9	1.0	3.7	0.8	0.6	1.9	0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.9	0.7	0.2	0.1	1.0	1.7
Medication for cholesterol	0.6	0.9	2.0	1.4	-0.1	1.0	0.8	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.3	-0.8	0.2	0.4	0.1
Back pain experienced in last month	0.3	0.5	1.0	-1.0	-0.6	0.2	0.3	1.0
Mineral and other dietary supplements	0.8	1.1	4.1	-2.0	-0.5	0.8	-0.5	0.2
Breast cancer (self-reported)	0.4	0.5	1.2	-0.2	-0.9	1.1	0.2	-0.7
Asthma (self-reported)	1.4	2.7	6.0	1.8	0.3	1.5	2.4	1.3
Osteoporosis (self-reported)	0.7	0.9	2.1	0.5	-0.4	-1.1	0.9	-1.4
Osteoarthritis (self-reported)	0.9	1.2	2.6	1.4	-0.0	1.6	0.3	1.1
Medication: Aspirin	2.6	3.4	15.6	3.9	0.6	0.8	0.6	0.5
Medication: Gliclazide	0.3	0.3	0.6	0.4	-0.7	0.4	-0.8	-0.1
Illnesses of father: None of the above (group 1)	1.0	1.2	2.8	-0.0	1.4	-1.0	1.7	-0.7
Smoking status: Current	0.9	1.5	3.3	1.8	-1.1	0.6	0.8	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.1	0.5	0.4	-0.7	-0.7
Whole body water mass	0.4	2.2	4.9	1.3	-1.0	2.2	1.7	0.7
Leg predicted mass (right)	0.8	4.2	10.9	1.5	-1.0	3.3	2.3	1.3
Arm fat mass (left)	0.3	1.3	2.6	0.9	0.7	1.6	1.6	0.1
Number of self-reported non-cancer illnesses	0.8	1.4	3.6	1.9	-0.4	0.9	1.6	0.1
Average weekly champagne plus white wine intake	0.8	1.1	4.1	-0.6	2.0	0.6	-0.1	0.9
Miserableness	1.6	2.8	5.8	-1.1	-2.4	-0.8	1.5	-2.0
Guilty feelings	0.5	0.7	1.5	0.4	-1.2	-0.2	0.9	1.0
Wears glasses or contact lenses	1.9	2.2	4.4	0.1	1.9	1.2	-1.1	2.1
Ever taken oral contraceptive pill	1.1	1.2	4.2	-0.2	0.4	-0.1	-2.0	-1.3
Hearing aid user	3.2	3.6	6.2	-1.2	1.0	-2.5	2.2	-2.2
Mother’s age at death	0.9	1.2	3.1	0.7	-1.1	1.0	-0.5	1.8
Financial situation satisfaction	2.1	2.6	3.7	1.0	-1.9	1.8	1.8	1.4
Tinnitus: Yes, now most or all of the time	2.3	2.7	6.9	1.9	-2.6	1.7	0.0	0.3
Commuting to job workplace: Public transport	1.1	1.3	4.3	0.7	-0.2	2.1	-0.2	1.3
Eye problems/disorders: Glaucoma	1.0	1.2	4.4	-0.5	0.4	1.0	2.1	-0.1
Medication: Blood pressure	0.9	1.6	4.5	-1.1	0.4	-1.1	-1.1	-2.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	1.4	0.7	1.1	0.3	0.2
Supplements: Fish oil (including cod liver oil)	1.4	1.8	6.0	2.5	0.1	0.5	1.6	0.3
High cholesterol (Self-reported)	1.2	2.1	7.1	2.7	1.8	-0.0	0.1	-0.4
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.8	0.3	-0.4	-0.7	0.2
Medication: Paracetamol	1.4	2.2	5.2	2.3	-0.6	1.8	-0.5	1.5
Medication: Lisinopril	1.5	1.9	6.3	2.5	-0.8	0.9	-1.3	0.5
Medication: Atorvastatin	1.5	1.9	6.6	2.6	0.7	1.0	1.2	0.3
Illnesses of father: High blood pressure	0.9	1.1	2.0	-0.7	-1.1	1.4	-1.0	1.0
Alcohol drinker status: Never	0.0	0.0	0.1	-0.0	0.1	-0.1	0.2	0.3
Ever smoked	0.7	1.2	2.6	1.4	1.6	-0.6	0.9	0.3
Basal metabolic rate	0.3	1.9	4.2	1.2	-0.6	2.0	1.8	0.5
Leg fat percentage (left)	0.6	2.1	5.5	0.5	2.3	-0.9	1.2	-1.5
Arm fat-free mass (left)	0.3	1.5	3.2	1.2	-0.6	1.6	1.8	0.1
Number of operations (self-reported)	0.9	1.3	2.9	0.9	1.7	0.1	0.0	-1.7
Average weekly beer plus cider intake	1.9	2.8	9.7	1.2	0.7	-3.1	-0.3	-1.5
Irritability	0.8	1.4	2.5	1.2	-1.6	0.8	0.4	1.5
Risk taking	0.9	1.3	5.2	0.7	0.2	0.7	2.3	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	-0.2	0.8	-1.2	-0.1	-0.5
Fractured/broken bones in last 5 years	1.7	2.2	8.0	0.4	0.4	-1.7	2.8	0.0
Age started oral contraceptive pill	1.0	1.2	5.0	0.3	2.2	0.1	-1.0	-0.1
Diastolic blood pressure, automated reading	0.8	2.4	3.8	-1.7	-1.2	0.4	2.0	-1.9
Ever depressed for a whole week	2.2	2.7	5.0	-1.5	-1.8	1.3	2.2	1.1
Unable to work because of sickness or disability	2.6	3.4	16.2	4.0	0.2	-0.3	0.8	0.4
Commuting to job workplace: Cycle	0.8	0.9	2.1	-1.0	0.6	-1.5	-0.8	0.7
Myopia	1.8	2.6	6.2	-2.5	-1.3	-1.6	0.6	-1.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.9	-1.7	0.1	-1.0	-0.1	-0.1
Cholesterol lowering medication	0.8	1.2	3.3	0.4	1.5	-0.2	-0.2	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	3.1	1.8	0.5	1.7	0.9	1.8
Pain experienced in last month	0.8	1.4	2.9	-0.7	1.0	-1.7	0.2	-1.6
Supplements: Calcium	1.9	2.1	7.4	1.2	2.7	-1.0	-0.6	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.9	-0.6	-0.0	1.4	-0.3	0.9
Heart attack/myocardial infarction (self-reported)	3.2	4.2	16.8	4.1	0.7	1.8	-0.1	0.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	4.1	1.2	-0.5	1.7	2.0	2.0
Heart disease (siblings)	1.0	1.2	3.8	1.4	0.0	-0.0	-1.9	-0.1
Alcohol drinker status: Previous	0.4	0.4	0.9	0.4	-1.0	0.9	-0.3	0.3
Pack years of smoking	0.6	0.8	1.7	1.1	-0.8	0.1	1.3	0.7
Impedance of whole body	2.2	11.2	32.6	-1.5	1.8	-5.7	-3.3	-2.7
Leg fat mass (left)	0.4	1.4	2.7	1.3	1.4	0.5	1.6	-0.7
Arm predicted mass (left)	0.3	1.6	4.0	0.9	-0.5	1.7	2.0	0.3