Hub : Genes

STEAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1340 0.0330 6.8e-11 0.118 0.105 0.125 0.117 0.124 3.6e-14 9.7e-13 6.3e-15 4.3e-14 7.7e-15
2 GTEx Brain Cortex 0.4140 0.1010 1.6e-04 0.009 NA 0.066 NA 0.036 1.8e-01 NA 7.0e-03 NA 3.6e-02
3 GTEx Esophagus Mucosa 0.2980 0.0510 0.0e+00 0.418 NA 0.403 NA 0.326 4.7e-30 NA 9.7e-29 NA 2.2e-22
4 GTEx Pancreas 0.1530 0.0580 1.9e-03 -0.003 NA 0.036 NA 0.004 4.7e-01 NA 1.2e-02 NA 2.1e-01
5 ROSMAP Brain Pre-frontal Cortex 0.1000 0.0254 4.1e-12 0.078 0.109 0.118 0.110 0.121 3.2e-10 8.0e-14 6.9e-15 5.5e-14 2.8e-15
6 TCGA Breast Invasive Carcinoma 0.0143 0.0091 1.2e-03 0.003 0.007 0.005 NA 0.004 5.9e-02 1.1e-02 2.2e-02 NA 4.2e-02
7 TCGA Colon Adenocarcinoma 0.0430 0.0300 8.9e-03 0.032 0.038 0.021 NA 0.034 5.8e-03 2.9e-03 2.1e-02 NA 4.6e-03
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0505 0.0262 5.7e-06 0.050 0.054 0.063 NA 0.054 2.4e-06 1.1e-06 1.5e-07 NA 1.1e-06
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0253 0.0157 5.4e-03 0.015 0.016 0.018 NA 0.011 7.5e-03 6.1e-03 3.4e-03 NA 1.8e-02
10 TCGA Liver Hepatocellular Carcinoma 0.1390 0.0840 3.0e-04 0.030 0.059 0.064 NA 0.050 1.4e-02 9.7e-04 6.0e-04 NA 2.1e-03
11 TCGA Lung Adenocarcinoma 0.0264 0.0154 8.9e-04 0.038 0.025 0.030 NA 0.035 2.8e-05 5.9e-04 1.6e-04 NA 5.6e-05
12 TCGA Lung Squamous Cell Carcinoma 0.0376 0.0207 4.2e-05 0.027 0.031 0.015 NA 0.026 4.2e-04 1.8e-04 6.6e-03 NA 5.4e-04
13 TCGA Ovarian Serous Cystadenocarcinoma 0.0620 0.0380 3.2e-04 0.038 0.047 0.038 NA 0.040 1.2e-03 3.7e-04 1.3e-03 NA 1.0e-03
14 TCGA Pancreatic Adenocarcinoma 0.0890 0.0510 9.2e-04 0.022 0.006 -0.004 NA 0.009 4.1e-02 1.7e-01 5.1e-01 NA 1.3e-01
15 TCGA Prostate Adenocarcinoma 0.0331 0.0201 2.3e-03 0.014 0.024 0.018 NA 0.020 1.2e-02 1.3e-03 4.9e-03 NA 3.5e-03
16 TCGA Stomach Adenocarcinoma 0.0520 0.0330 2.5e-03 0.008 0.043 0.033 NA 0.032 7.8e-02 4.2e-04 1.8e-03 NA 2.1e-03
17 TCGA Thyroid Carcinoma 0.0220 0.0140 4.7e-03 0.009 0.013 0.001 NA 0.006 3.9e-02 1.8e-02 2.2e-01 NA 7.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.4 0.6 2.4 -0.3 -1.6 0.7 -1.4 -0.5 0.4 0.7 1.4 0.1 -0.2 0.7 0.5 0.7 0.5 0.7 0.1 0.8
Bipolar Disorder or Schizophrenia 0.8 2.0 4.1 0.8 -1.0 1.6 -2.0 0.4 1.4 1.3 2.0 -0.8 -1.6 1.7 1.6 1.7 1.5 1.2 0.9 1.7
Depressed Affect (Nagel 2018) 0.4 0.8 2.2 -0.2 -1.4 -1.1 0.8 -0.8 -0.9 -0.8 -1.5 0.3 0.4 -0.7 -0.9 -1.1 -1.0 -0.7 -0.4 -1.2
Depression (Nagel 2018) 1.7 2.5 5.5 1.5 0.6 1.8 -1.2 0.5 2.3 2.1 1.8 -0.7 -1.5 1.7 2.1 1.7 2.0 0.5 0.5 2.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 5.8 0.2 -1.2 0.8 -2.4 0.8 0.5 0.2 0.8 -0.5 -0.6 0.6 0.6 0.8 0.6 0.8 0.7 0.6
Neuroticism (Nagel 2018) 0.3 0.6 4.5 -0.8 -2.1 -0.3 0.0 -1.3 0.2 1.0 -0.1 0.8 0.3 -0.2 0.1 -0.4 0.2 -1.0 -1.0 0.3
Schizophrenia (2018) 0.9 1.9 3.6 1.3 0.1 1.5 -1.5 0.8 1.5 1.1 1.5 -1.2 -1.9 1.6 1.7 1.6 1.6 1.0 1.0 1.6
Schizophrenia vs Biploar Disorder 0.3 0.4 3.0 0.3 1.7 0.1 0.7 0.5 0.4 0.7 -0.2 0.6 0.6 -0.0 -0.0 0.0 0.4 -0.9 -0.8 0.5
Worry (Nagel 2018) 0.2 0.5 1.7 -0.9 -1.3 -0.2 -1.0 -0.8 0.1 1.0 0.0 0.9 0.6 0.2 -0.1 -0.2 0.0 -0.9 -1.2 0.4
Alzheimer’s Disease (in mother) 0.7 0.8 2.5 0.4 1.0 0.2 -1.4 0.7 -1.0 -1.5 0.3 -1.0 -0.2 -0.1 -0.4 0.1 -0.8 1.6 1.3 -1.1
Alzheimer’s Disease (in father) 2.7 3.0 4.8 -2.0 -0.1 -2.2 0.8 -1.7 -1.7 -0.7 -2.1 1.7 1.5 -1.9 -1.8 -2.2 -1.9 -2.0 -1.7 -1.6
Alzheimer’s Disease (including proxy) 0.5 0.8 1.9 -0.7 0.8 -0.8 -0.9 -0.4 -1.4 -1.2 -0.6 0.3 0.7 -1.1 -1.0 -0.9 -1.4 0.2 0.0 -1.2
Crohns Disease (2017) 0.6 1.3 3.7 1.1 1.3 0.5 -1.2 1.8 -0.1 -1.6 0.1 -1.9 -0.8 0.9 -0.0 0.5 0.0 1.7 1.8 -0.8
Irritable Bowel Disease (IBD) 0.2 0.4 1.1 0.8 0.2 0.4 -0.8 1.1 0.0 -0.8 0.2 -1.0 -0.7 0.5 -0.0 0.3 0.0 0.9 1.0 -0.2
Ulcerative Colitis (UC) 0.0 0.1 0.4 0.2 -0.6 0.2 -0.3 0.0 0.3 0.3 0.2 0.2 -0.5 0.0 0.1 0.0 0.1 -0.2 -0.1 0.5
Major Depression (MDD) 0.4 0.5 4.1 -0.8 -2.0 -0.4 -1.5 -0.7 -0.5 -0.0 -0.0 0.3 -0.0 0.2 -0.3 -0.3 -0.4 -0.1 -0.3 -0.3
Reaction Time 2.3 4.5 9.1 1.7 0.4 2.5 -2.6 0.8 2.3 1.8 3.0 -1.5 -1.8 2.4 2.5 2.6 2.5 1.9 1.4 2.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 3.2 0.2 -0.4 0.4 -1.8 0.7 0.2 -0.1 0.1 -0.1 0.2 0.2 -0.1 0.3 0.2 0.1 0.1 0.3
Breast Cancer 0.2 0.5 3.9 0.7 0.1 0.4 2.0 -0.2 0.6 1.2 0.6 0.1 0.3 0.3 0.7 0.5 0.6 -0.4 -0.6 0.8
Ovarian Cancer 0.7 0.9 3.3 -0.3 1.0 0.2 0.7 -0.9 1.0 1.8 0.3 1.2 1.0 -0.2 0.3 0.1 0.9 -1.5 -1.5 1.2
Prostate Cancer 1.0 1.5 4.4 1.3 1.6 1.4 0.1 2.1 0.8 -0.4 0.9 -1.7 -0.7 1.2 0.8 1.4 0.8 1.7 1.5 0.4
Age at First Birth 3.3 4.8 7.1 -2.4 -1.0 -2.5 1.3 -1.8 -2.6 -1.3 -2.2 2.4 2.3 -2.4 -2.7 -2.7 -2.6 -1.8 -1.9 -2.2
Bipolar Disorder (2011) 2.2 2.1 3.9 -2.0 -0.5 -1.6 0.1 -0.9 -2.0 -1.2 -1.2 1.3 1.9 -1.4 -1.9 -1.6 -1.8 -0.7 -1.1 -1.7
Body Mass Index (BMI) (2010) 0.1 0.1 0.5 -0.2 -0.5 -0.1 0.5 -0.1 -0.2 0.1 0.1 0.3 0.7 -0.3 -0.3 -0.1 -0.2 -0.3 -0.4 -0.0
Coronary Artery Disease (CAD) 0.2 0.2 0.6 -0.5 -0.8 -0.3 0.6 -0.1 -0.4 0.2 -0.0 0.8 0.7 -0.5 -0.3 -0.4 -0.3 -0.4 -0.6 -0.1
Crohns Disease (2012) 0.7 1.0 2.7 0.8 0.2 1.1 -1.7 1.4 0.6 -0.1 1.0 -1.5 -0.6 1.4 0.7 1.1 0.8 1.4 1.0 0.3
Mean Putamen Volume 1.1 1.3 5.1 0.6 -0.1 0.5 -0.6 2.0 -0.7 -2.2 -0.0 -1.6 -0.1 0.3 -0.7 0.3 -0.7 1.8 1.8 -1.1
Fasting Glucose 6.2 7.4 13.5 -2.9 0.0 -3.6 0.7 -3.2 -2.6 -1.0 -3.7 3.1 1.8 -3.2 -2.7 -3.5 -2.7 -3.3 -2.6 -2.2
HbA1C 0.9 1.0 4.9 -0.5 0.9 -0.8 2.2 -0.9 -0.8 -0.1 -0.7 0.9 1.5 -0.7 -0.8 -0.8 -0.7 -0.8 -1.1 -0.7
HDL Cholesterol 0.3 0.6 1.9 0.1 1.4 0.8 -0.9 0.6 0.9 1.0 0.7 0.8 1.1 -0.1 -0.0 0.5 0.3 -0.6 -0.6 1.0
LDL Cholesterol 0.5 0.8 2.2 1.3 0.8 1.3 0.0 1.5 1.0 0.0 0.8 -1.0 -0.5 0.7 0.6 1.1 0.2 0.9 1.0 0.8
Lupus 1.7 2.5 9.8 -1.8 -3.1 -1.5 2.4 -2.0 -0.9 -0.0 -1.2 1.4 1.1 -1.4 -1.1 -1.6 -1.0 -1.6 -1.5 -0.9
Neuroticism (2016) 0.1 0.2 1.5 -0.6 -1.2 0.1 -0.6 -0.3 0.3 0.4 0.3 0.1 -0.5 -0.0 0.5 0.1 0.3 0.2 0.2 0.3
Primary Biliary Cirrhosis 0.3 0.4 1.1 0.8 0.1 0.7 0.1 0.8 0.3 -0.2 0.7 -1.1 -0.7 0.8 0.6 0.7 0.4 1.0 0.9 0.1
Rheumatoid Arthritis 0.2 0.2 1.4 0.2 -0.7 0.0 -1.2 0.0 0.0 -0.3 0.1 -0.4 -0.8 -0.1 0.3 -0.0 0.1 0.5 0.7 -0.2
Schizophrenia (2014) 1.1 2.3 4.1 1.5 -0.3 1.7 -1.7 1.0 1.6 1.1 1.6 -1.3 -2.0 1.8 1.8 1.7 1.7 1.3 1.2 1.6
Triglycerides 0.2 0.3 1.3 -0.3 -1.1 -0.7 0.5 -0.7 -0.0 0.3 -0.6 0.8 -0.5 -0.5 -0.1 -0.7 -0.2 -0.9 -0.5 0.0
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.5 -1.6 -0.8 -0.9 0.9 -0.9 -1.1 -0.2 -0.4 1.1 1.0 -0.9 -1.1 -1.0 -1.1 -0.7 -1.0 -0.7
Ulcerative Colitis 0.3 0.5 1.2 -0.4 -0.7 -0.6 -0.4 0.3 -0.7 -1.1 -1.1 0.2 0.1 -0.8 -0.9 -0.8 -0.9 -0.3 0.0 -0.8
Blood Eosinophil Count 0.2 1.3 3.0 -1.4 -0.8 -1.0 1.2 -1.4 -1.4 -0.9 -0.5 1.1 1.5 -1.7 -1.3 -1.1 -1.2 -0.5 -0.6 -1.1
Blood Platelet Count 0.1 0.6 2.1 -1.1 -0.9 -0.6 -0.7 -1.4 -0.5 0.2 -0.5 1.1 0.0 -0.9 -0.3 -0.9 -0.5 -0.9 -0.8 -0.2
Blood Red Count 0.1 1.0 7.6 -0.7 0.4 -0.5 -2.8 0.0 -1.1 -0.9 -0.2 0.7 0.9 -0.6 -1.3 -0.8 -1.1 0.1 -0.2 -0.9
Blood White Count 0.1 0.4 2.9 0.2 0.5 -0.3 -1.7 -0.0 -0.5 -1.2 -0.5 -0.3 -0.3 -0.5 -0.6 -0.4 -0.5 0.2 0.7 -0.7
Heel T-Score 0.0 0.4 2.1 -0.5 -1.4 0.0 -1.4 0.1 0.1 0.3 -0.1 0.6 0.5 0.3 -0.4 0.1 -0.1 -0.5 -0.6 0.4
BMI 0.4 2.1 5.1 1.7 2.0 1.4 -2.3 2.1 0.7 -0.6 0.9 -1.9 -1.2 1.3 0.8 1.3 0.8 1.7 1.8 0.2
Height 0.2 3.7 9.6 -2.6 -0.9 -1.5 3.0 -3.1 -0.4 2.0 -0.4 2.9 1.3 -1.7 -0.4 -1.4 -0.4 -2.7 -2.8 0.5
Waist Hip Ratio (WHR) 0.3 1.3 8.4 -0.8 -2.9 0.0 -0.9 -1.6 0.7 1.6 1.0 0.8 -1.2 -0.1 1.1 0.2 0.7 -0.5 -0.4 1.3
Systolic Blood Pressure 0.1 0.4 1.5 -0.6 -0.9 -0.5 -1.2 -0.7 0.1 0.6 -0.0 0.6 -1.0 -0.1 0.5 -0.2 0.1 -0.5 -0.3 0.4
Smoking Status 1.8 4.3 12.0 3.5 2.1 2.2 -1.4 2.4 2.1 0.1 1.3 -2.6 -2.1 2.0 2.0 2.2 2.0 1.9 2.3 1.3
Allergy or Eczema 0.9 2.3 5.2 -1.5 -1.1 -1.7 1.1 -0.8 -1.9 -2.3 -1.9 0.3 0.3 -1.8 -1.7 -1.8 -2.0 -0.2 0.3 -2.3
Cardiovascular Disease 0.1 0.3 2.5 0.1 -0.1 0.2 -1.6 0.2 -0.0 -0.2 0.5 -0.5 -0.7 0.2 0.4 0.3 0.1 0.8 0.7 -0.1
Hypothyroidism (self reported) 0.5 1.1 3.1 -1.5 0.3 -0.7 0.2 -1.7 0.0 1.2 -0.6 1.5 1.0 -0.8 -0.2 -0.7 -0.1 -1.8 -1.7 0.4
Respiratory disease 0.3 0.6 1.9 -0.5 -0.2 -0.7 -0.0 -0.7 -1.3 -1.4 -0.0 -0.3 -0.2 -0.5 -0.7 -0.6 -1.0 0.9 0.7 -1.3
Type 2 Diabetes (T2D) (2018) 1.2 2.3 4.6 -1.8 -0.8 -2.0 0.7 -2.1 -1.6 -0.8 -1.5 1.4 0.7 -2.1 -1.3 -1.9 -1.6 -1.4 -1.0 -1.4
Lung FEV1/FVC ratio 2.9 14.5 37.6 -2.0 1.6 -4.2 1.6 -0.7 -5.4 -5.9 -4.8 0.4 2.9 -3.7 -5.0 -4.2 -5.4 -0.3 -0.1 -6.1
Lung FVC 0.1 0.6 2.6 1.0 1.6 0.8 0.5 0.8 0.9 0.4 0.4 -0.5 -0.5 0.9 0.6 0.7 0.8 0.3 0.4 0.7
Neuroticism 0.6 1.5 11.1 -1.3 -3.3 -1.0 0.2 -1.3 -0.7 0.3 -0.8 1.3 1.0 -0.8 -0.7 -1.1 -0.7 -1.3 -1.4 -0.4
Chronotype (morning person) 0.6 1.4 5.9 -0.6 -0.9 -0.7 -0.5 0.4 -1.7 -2.4 -0.6 -0.8 -0.0 -0.7 -1.2 -0.7 -1.4 1.2 1.2 -1.9
Hair Pigment 0.0 0.8 2.9 0.2 0.4 -0.8 0.6 0.1 -1.2 -1.7 -0.9 -0.3 -0.0 -1.2 -0.8 -0.9 -1.1 0.4 0.7 -1.5
Tanning 0.1 0.7 4.9 -0.9 -2.2 -0.2 1.0 -1.0 0.0 0.8 -0.2 1.0 0.4 -0.0 -0.4 -0.4 -0.2 -1.1 -1.1 0.4
Hand grip strength (left) 0.3 0.7 1.8 -1.3 -0.5 -0.7 1.3 -0.7 -0.3 0.3 -0.4 1.4 0.5 -0.8 -0.6 -0.8 -0.4 -1.2 -1.0 0.1
Number of treatments/medications taken 0.5 0.8 3.7 0.5 -1.0 0.6 -0.1 0.2 0.6 0.2 0.7 -1.0 -1.9 0.7 1.4 0.8 0.8 1.0 1.2 0.5
Average weekly spirits intake 0.7 0.9 3.2 -0.2 0.7 -1.1 0.5 0.0 -0.6 -0.9 -1.8 0.7 0.8 -1.2 -1.2 -1.1 -0.9 -1.2 -0.6 -0.8
Sensitivity / hurt feelings 1.7 2.9 12.0 -2.0 -3.5 -1.5 1.5 -2.6 -1.1 0.6 -0.7 2.0 1.4 -1.6 -0.9 -1.5 -1.0 -1.8 -1.9 -0.5
Frequency of depressed mood in last 2 weeks 1.3 1.8 4.0 1.4 -0.8 1.4 -1.1 0.4 2.0 1.7 1.2 -0.6 -1.5 1.1 1.9 1.4 1.9 0.2 0.5 1.8
Hearing difficulty/problems: Yes 0.2 0.3 1.1 -0.6 0.0 -0.8 -0.2 -0.6 -0.2 -0.0 -1.0 0.6 -0.2 -0.8 -0.4 -0.8 -0.4 -1.1 -0.5 -0.2
Relative age of first facial hair 1.1 2.3 5.3 1.7 -0.4 1.8 -0.0 1.0 2.3 2.2 1.4 -0.6 -0.5 1.6 1.9 1.7 2.2 0.0 -0.1 2.2
Other serious medical condition/disability diagnosed by doctor 4.1 5.3 12.2 2.3 -1.4 2.4 -2.3 2.6 1.3 -0.4 2.5 -3.0 -2.6 2.3 2.1 2.4 1.6 3.5 3.2 0.9
Ever used hormone-replacement therapy (HRT) 0.1 0.2 1.3 0.0 -1.1 0.2 0.7 -0.2 0.3 0.2 0.4 -0.1 -0.3 0.2 0.3 0.2 0.3 0.2 0.2 0.3
Ever had hysterectomy (womb removed) 2.1 2.4 4.5 -0.7 1.3 -1.6 1.1 -0.6 -1.5 -1.1 -1.9 1.6 2.1 -1.8 -2.1 -1.8 -1.7 -1.6 -1.4 -1.4
Systolic blood pressure, automated reading 0.3 0.8 2.2 -0.9 -1.0 -0.9 -0.5 -1.5 -0.0 0.9 -0.6 1.4 -0.7 -0.9 0.2 -0.8 -0.1 -1.4 -0.9 0.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.4 0.2 -0.1 0.2 0.5 0.6 -0.1 -0.6 0.0 -0.3 -0.0 0.0 -0.3 0.1 -0.0 0.4 0.5 -0.2
Angina 0.1 0.1 0.4 -0.7 0.3 -0.2 -0.1 -0.6 -0.4 0.3 0.6 0.2 0.6 0.0 0.1 -0.1 -0.2 0.3 -0.4 -0.3
Medication for hormone replacement therapy 0.8 0.9 3.0 1.7 0.9 0.9 0.9 1.2 1.2 0.6 0.3 -0.7 -0.6 1.1 0.8 1.0 1.0 -0.0 0.3 1.1
Vitamin and mineral supplements 0.9 1.2 3.8 0.8 1.5 0.5 -1.4 1.1 -0.1 -1.0 0.6 -1.5 -1.2 0.8 0.5 0.7 0.0 1.9 1.8 -0.5
Supplements: Zinc 0.2 0.2 1.3 0.2 1.1 0.4 -0.7 0.1 0.2 0.4 0.5 -0.4 0.5 0.5 0.3 0.4 0.3 0.3 -0.2 0.1
Medication: Co-codamol 0.1 0.1 0.5 0.5 0.2 0.2 0.7 0.4 0.6 0.2 -0.3 0.1 0.2 -0.1 0.0 0.1 0.4 -0.5 -0.2 0.4
Medication: Metformin 0.0 0.0 0.2 0.1 0.1 -0.2 -0.2 0.1 -0.2 -0.2 -0.1 0.1 0.3 -0.2 -0.4 -0.2 -0.3 -0.2 -0.2 -0.2
Diabetes (father) 2.0 2.5 4.5 -1.5 0.4 -2.1 1.6 -1.2 -1.8 -1.8 -2.1 0.9 0.8 -1.9 -1.8 -2.0 -1.9 -1.0 -0.5 -1.9
Diabetes (mother) 1.1 1.4 2.6 -1.0 -1.1 -1.5 1.0 -1.4 -0.8 -0.0 -1.4 1.5 0.5 -1.3 -0.9 -1.5 -1.0 -1.6 -1.2 -0.6
Severe depression (siblings) 0.5 0.5 7.0 0.2 2.7 -0.0 0.3 0.4 -0.3 -0.6 0.1 -0.3 0.5 -0.1 -0.4 -0.0 -0.2 0.3 0.2 -0.4
Pack years adult smoking proportion 0.8 1.2 3.5 1.2 0.2 1.1 -1.5 1.3 0.2 -0.8 1.1 -1.6 -0.8 1.0 0.5 1.1 0.4 1.9 1.6 -0.0
Impedance of leg (right) 0.8 3.8 6.1 -2.0 -1.2 -2.5 1.3 -1.8 -2.4 -1.9 -2.3 1.5 1.3 -2.4 -2.3 -2.5 -2.4 -1.2 -0.9 -2.3
Leg fat-free mass (left) 0.8 4.2 6.6 2.2 1.8 2.6 -0.5 2.0 2.6 2.0 2.3 -1.3 -1.4 2.4 2.4 2.5 2.6 1.1 0.9 2.6
Trunk fat percentage 0.1 0.3 2.2 -0.1 0.6 0.0 -1.5 -0.4 0.2 0.6 0.5 0.2 -0.5 0.0 0.6 0.1 0.3 -0.0 -0.1 0.4
Hand grip strength (right) 0.2 0.5 1.6 -1.1 -0.7 -0.4 1.0 -0.9 -0.0 0.7 0.1 1.3 -0.0 -0.6 -0.1 -0.5 -0.0 -0.9 -0.8 0.4
Townsend deprivation index at recruitment 2.8 3.9 6.2 2.4 -0.3 2.4 -1.5 2.5 2.0 0.4 2.1 -2.2 -2.0 2.1 1.9 2.3 2.0 2.2 2.3 1.5
Current tobacco smoking 0.5 0.9 3.1 1.6 1.8 0.8 -1.0 1.8 0.7 -0.5 -0.2 -1.2 -0.1 0.7 0.3 0.7 0.5 0.7 0.9 -0.0
Average weekly fortified wine intake 0.2 0.2 1.9 -0.1 -1.4 -0.1 0.7 -0.7 0.0 0.2 0.1 0.2 -0.3 -0.2 0.3 -0.1 0.2 -0.2 -0.0 0.2
Maternal smoking around birth 0.7 1.0 4.1 1.2 0.6 0.1 -0.3 0.9 0.2 -1.3 -0.9 -1.7 -2.0 0.4 0.5 0.1 0.1 0.9 1.8 -0.7
Fed-up feelings 0.2 0.3 2.8 0.6 -1.7 -0.2 0.4 0.2 0.0 -0.7 -0.6 -0.6 -0.5 -0.2 0.0 -0.2 -0.0 0.2 0.7 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.5 0.9 0.3 1.1 -1.1 0.6 1.2 0.9 1.0 -0.8 -0.9 1.2 1.2 1.1 1.2 0.6 0.6 1.1
Relative age voice broke 0.2 0.3 1.7 0.1 -1.3 0.6 -0.2 0.1 0.6 0.8 0.8 -0.0 0.2 0.6 0.6 0.6 0.7 0.2 -0.2 0.6
Taking other prescription medications 0.3 0.5 2.5 0.2 -1.0 0.4 -0.3 -0.1 0.2 -0.1 0.8 -0.8 -1.6 0.4 0.9 0.5 0.3 1.1 1.2 0.1
Age when periods started (menarche) 0.4 1.1 2.9 1.5 1.7 0.9 -0.4 0.5 1.0 0.9 1.1 -0.6 -1.0 0.8 1.4 1.1 1.1 0.7 0.6 1.1
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 2.1 0.4 1.1 0.5 -1.5 0.2 0.8 1.3 0.2 0.6 0.6 0.5 0.4 0.4 0.6 -0.8 -1.0 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.7 0.6 -1.4 0.1 -0.1 0.6 0.1 -1.2 -0.4 -1.2 -1.6 0.1 0.4 0.2 0.1 1.0 1.6 -0.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.5 -0.8 -1.6 -0.6 1.4 -0.5 -0.8 -0.3 -0.4 0.4 1.4 -0.3 -1.0 -0.6 -0.8 -0.5 -0.9 -0.7
Qualifications: CSEs or equivalent 0.3 0.4 1.0 0.2 0.8 -0.4 0.4 0.7 -0.5 -0.4 -1.0 0.1 0.9 0.1 -0.8 -0.5 -0.7 -0.3 -0.6 -0.8
Serious illness, injury or assault to yourself 0.2 0.2 0.9 0.9 0.2 0.4 -0.9 0.2 0.2 0.0 0.2 -0.4 -0.5 0.6 0.4 0.2 0.2 0.4 0.3 0.0
High blood pressure 0.4 1.2 7.8 0.8 0.1 0.8 -2.8 0.6 0.5 0.1 1.2 -0.9 -1.4 1.0 1.1 0.9 0.6 1.2 1.1 0.6
Hayfever, allergic rhinitis or eczema 0.9 1.9 3.7 -1.7 -1.3 -1.5 1.4 -0.7 -1.7 -1.9 -1.5 0.4 0.5 -1.4 -1.6 -1.6 -1.8 -0.2 0.0 -1.9
Multivitamins +/- minerals 0.3 0.4 0.9 0.9 -0.0 0.7 1.0 0.6 0.9 0.6 0.2 -0.3 -0.2 0.5 0.6 0.6 0.8 -0.3 -0.0 0.8
Stomach or abdominal pain in last month 0.1 0.1 0.5 0.7 0.2 0.0 -0.3 0.7 0.1 -0.2 -0.1 -0.2 0.0 -0.0 -0.2 0.0 -0.1 0.0 0.1 -0.0
Supplements: Glucosamine 1.2 1.5 5.0 -1.6 -0.5 -1.2 2.2 -1.2 -1.1 -0.3 -1.1 1.2 1.4 -1.3 -1.2 -1.2 -1.1 -1.2 -1.2 -0.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.5 -0.4 -0.5 0.1 -0.5 -0.0 -0.3 -0.9 0.3 -0.7 -1.0 -0.0 0.2 0.0 -0.1 1.1 1.2 -0.5
Medication: Atenolol 0.2 0.3 0.6 0.7 0.4 0.4 -0.6 0.3 0.7 0.8 0.0 -0.1 -0.5 0.5 0.7 0.3 0.6 -0.4 -0.2 0.6
Medication: Levothyroxine sodium 0.3 0.5 1.7 -0.3 -0.1 0.4 -0.4 -0.6 1.0 1.3 0.7 0.2 -0.5 0.2 0.9 0.5 1.0 -0.4 -0.2 1.1
Sitting height 0.1 0.4 2.8 0.1 1.6 -0.2 1.7 0.1 -0.1 -0.1 -0.5 0.3 0.3 -0.4 -0.3 -0.4 -0.2 -0.5 -0.3 -0.2
Chronic bronchitis/emphysema (father) 1.2 1.4 3.7 0.2 -0.1 1.1 -1.1 -0.6 1.4 1.9 1.9 -0.2 -1.4 0.8 1.7 1.1 1.6 0.4 0.3 1.7
High blood pressure (mother) 0.8 1.2 3.7 1.2 1.9 0.7 -1.4 1.9 0.4 -0.8 -0.1 -1.5 -1.2 0.9 0.4 0.7 0.3 1.1 1.4 -0.1
Body mass index (BMI) 1.0 4.1 5.7 2.2 1.9 2.3 -2.1 2.2 2.1 1.1 2.1 -1.8 -1.7 2.3 2.2 2.4 2.2 1.7 1.5 1.9
Impedance of leg (left) 0.9 4.2 7.1 -2.2 -1.3 -2.6 1.0 -2.0 -2.7 -2.0 -2.2 1.5 1.4 -2.5 -2.4 -2.6 -2.6 -1.1 -0.9 -2.5
Leg predicted mass (left) 0.8 4.1 6.4 2.2 1.8 2.5 -0.5 1.9 2.5 1.9 2.2 -1.3 -1.4 2.4 2.4 2.5 2.5 1.1 0.9 2.5
Trunk fat mass 0.1 0.6 1.4 0.5 1.1 0.6 -1.2 0.1 0.8 1.0 0.9 -0.1 -0.7 0.5 1.0 0.7 0.9 0.2 0.1 0.9
Waist circumference 0.5 1.9 3.6 1.2 1.0 1.4 -1.9 1.0 1.2 0.8 1.8 -1.1 -1.6 1.3 1.6 1.6 1.4 1.3 1.2 1.3
Number of incorrect matches in round 1.5 2.5 5.6 1.3 0.5 1.7 -2.4 1.1 1.3 0.3 1.6 -1.8 -2.0 1.7 1.6 1.7 1.5 1.9 1.9 1.0
Past tobacco smoking 0.2 0.4 1.1 -0.8 -0.6 0.4 -1.1 -0.5 0.0 0.4 1.0 -0.2 -0.7 0.5 0.7 0.4 0.3 0.8 0.4 0.2
Alcohol usually taken with meals 0.3 0.5 2.6 -0.7 -1.6 -0.4 1.2 -1.4 -0.3 0.6 0.4 0.9 0.1 -0.4 0.1 -0.3 -0.1 -0.3 -0.5 0.2
Nervous feelings 0.8 1.6 5.3 -1.4 -0.0 -0.8 -0.6 -1.5 0.2 1.7 -0.6 2.0 1.5 -0.9 -0.2 -0.8 0.0 -2.2 -2.3 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.0 1.1 0.0 0.9 -1.4 0.9 1.0 0.2 0.4 -0.8 -0.5 0.8 0.7 0.8 0.8 0.6 0.7 0.6
Hearing difficulty/problems with background noise 0.3 0.4 2.8 -0.6 -1.7 -0.3 0.0 -1.0 0.2 0.7 -0.1 0.4 -1.0 -0.3 0.5 -0.3 0.1 -0.6 -0.2 0.3
Hair/balding pattern: Pattern 2 1.3 1.6 4.3 0.1 -2.0 1.3 -0.8 0.2 0.6 0.2 2.1 -1.1 -1.4 1.2 1.4 1.3 1.1 2.0 1.5 0.7
Had menopause 0.2 0.2 1.0 0.3 -0.5 0.6 1.0 0.6 0.6 0.2 0.5 -0.1 0.0 0.4 0.2 0.6 0.6 0.2 0.2 0.6
Had other major operations 0.3 0.3 2.8 -0.5 -1.7 0.1 0.4 -0.2 -0.3 -0.2 0.4 -0.5 -0.6 0.4 0.3 0.1 -0.2 0.8 0.5 -0.3
Forced vital capacity (FVC) 0.1 0.4 5.4 0.3 0.6 -0.0 2.3 -0.3 0.2 0.0 -0.3 0.2 -0.2 0.0 0.0 -0.2 0.1 -0.3 -0.1 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 3.8 0.8 -1.1 0.4 -0.4 0.4 0.2 -1.0 0.2 -1.3 -1.9 0.1 0.7 0.4 0.3 1.4 1.9 -0.2
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 4.9 -2.0 -1.1 -1.4 2.1 -2.2 -0.8 0.6 -0.6 1.6 0.7 -1.6 -0.4 -1.2 -0.8 -1.5 -1.5 -0.3
Qualifications: None of the above 0.1 0.3 1.2 -0.9 -1.1 -0.2 -0.2 -0.7 -0.0 0.6 0.5 0.6 0.8 -0.2 -0.1 -0.1 -0.0 -0.4 -0.7 0.2
Financial difficulties in last 2 years 3.2 4.3 8.6 2.1 -0.4 2.1 -2.6 1.3 2.2 0.9 2.0 -2.1 -2.9 2.3 2.5 2.2 2.2 2.0 2.2 1.7
Mouth/teeth dental problems 1.2 1.8 4.2 -0.8 0.4 -1.5 1.3 -0.4 -1.5 -1.1 -2.0 0.8 1.4 -1.2 -1.7 -1.7 -1.7 -1.2 -1.1 -1.7
Heart attack 0.3 0.3 2.7 -0.2 1.7 -0.3 -0.1 -0.4 -0.0 0.3 -0.3 0.6 0.7 -0.7 -0.1 -0.4 0.0 -0.6 -0.6 -0.1
Allergy 0.5 1.1 4.0 1.4 2.0 0.9 -1.2 0.8 1.4 1.3 0.5 -0.1 0.1 0.8 0.9 0.9 1.2 -0.4 -0.4 1.4
Pain all over the body in last month 0.7 0.7 2.8 -0.7 0.6 -0.6 -0.5 -1.1 0.2 0.9 -0.9 1.3 0.6 -0.8 -0.2 -0.6 -0.1 -1.7 -1.4 0.4
Diabetes (self-reported) 0.3 0.4 1.7 -0.1 0.2 -0.6 1.3 -0.7 0.1 0.2 -0.7 0.7 0.4 -0.8 -0.3 -0.6 -0.1 -1.2 -0.7 -0.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.7 -0.2 1.3 -0.3 1.3 0.8 -0.4 -0.9 -1.0 -0.2 0.1 -0.2 -0.7 -0.4 -0.6 -0.2 0.1 -0.6
Medication: Ramipril 0.7 0.9 3.3 -0.0 -0.1 0.8 -1.1 -0.9 1.0 1.8 1.5 0.4 0.1 0.4 1.1 0.8 1.2 -0.2 -0.5 1.3
Medication: Simvastatin 0.5 0.7 2.9 -1.2 -1.7 -0.9 0.7 -1.1 -0.7 0.1 -0.5 0.9 0.7 -0.7 -0.6 -0.8 -0.7 -0.9 -1.0 -0.4
Fluid intelligence score 0.4 0.9 5.6 1.0 -0.4 1.0 -2.4 1.4 0.6 -0.3 0.5 -0.9 -0.6 0.9 0.4 0.9 0.6 0.8 0.9 0.5
Illnesses of siblings 0.3 0.4 1.3 1.1 0.7 0.6 -1.1 0.9 0.6 -0.0 0.2 -0.7 -0.5 0.9 0.3 0.6 0.5 0.5 0.5 0.3
Neuroticism score 0.5 1.0 6.2 -0.8 -2.5 -0.9 -0.3 -1.3 -0.6 0.1 -0.7 1.2 0.8 -0.9 -0.8 -0.9 -0.7 -1.0 -1.0 -0.4
Weight 0.5 2.5 3.6 1.6 1.7 1.9 -1.0 1.5 1.8 1.4 1.8 -1.1 -1.2 1.8 1.9 1.9 1.9 1.1 0.8 1.8
Impedance of arm (right) 2.2 10.3 25.0 -4.6 -3.3 -4.1 1.2 -5.0 -3.4 -0.6 -2.6 3.4 1.6 -3.8 -2.4 -3.9 -3.2 -2.8 -2.7 -2.5
Arm fat percentage (right) 0.2 0.6 3.2 0.1 0.8 0.5 -1.8 -0.1 0.7 1.0 0.8 -0.3 -1.0 0.6 1.1 0.6 0.8 0.2 0.2 0.8
Trunk fat-free mass 0.9 5.0 8.5 2.7 2.0 2.9 0.4 2.6 2.8 1.6 2.4 -1.7 -1.4 2.6 2.3 2.8 2.7 1.5 1.4 2.6
Hip circumference 0.4 1.7 3.9 1.4 2.0 1.5 -1.4 1.5 1.1 0.4 1.4 -1.3 -1.0 1.4 1.3 1.5 1.2 1.3 1.1 1.0
Time employed in main current job 0.6 0.7 1.3 1.2 0.5 1.0 0.0 1.1 0.9 0.5 0.9 -0.9 -0.6 1.1 0.9 1.1 0.8 0.9 0.6 0.7
Alcohol intake versus 10 years previously 0.3 0.4 4.8 -0.1 -2.2 -0.1 0.7 -0.8 0.1 0.6 0.3 0.3 -0.4 -0.4 0.4 -0.3 0.2 -0.3 -0.2 0.2
Father’s age at death 1.2 1.6 2.8 1.4 -1.5 1.4 -0.2 0.6 1.1 0.6 1.6 -1.2 -1.7 1.5 1.4 1.4 1.2 1.4 1.3 1.1
Worrier / anxious feelings 1.1 2.1 3.1 -1.7 -1.1 -1.7 -0.4 -1.4 -1.5 -0.4 -1.6 1.7 1.6 -1.1 -1.6 -1.7 -1.6 -1.6 -1.8 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.1 0.6 -0.6 0.6 -1.1 0.7 0.7 0.3 0.4 -0.4 -1.0 0.5 0.6 0.5 0.6 0.3 0.6 0.6
Falls in the last year 0.1 0.1 0.4 0.1 -0.4 0.1 -0.3 -0.6 0.3 0.7 0.4 0.3 -0.0 -0.2 0.4 0.2 0.4 -0.3 -0.3 0.6
Hair/balding pattern: Pattern 3 0.7 1.1 3.7 -0.1 1.5 -0.8 0.2 0.2 -0.7 -0.1 -1.3 0.9 1.9 -0.5 -1.3 -0.9 -0.9 -1.4 -1.5 -0.6
Number of live births 0.2 0.3 1.9 -0.6 -1.4 0.2 0.6 0.6 -0.1 -0.2 0.6 -0.3 0.1 0.5 0.0 0.4 -0.0 0.7 0.3 0.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 5.2 -0.2 0.8 -1.0 2.3 -0.4 -1.1 -1.5 -1.5 0.1 0.1 -0.8 -1.0 -1.1 -1.1 -0.2 0.2 -1.4
Pulse rate 2.0 3.3 6.6 2.5 2.0 1.9 0.0 2.4 1.2 -0.5 1.5 -2.6 -1.4 2.1 1.4 2.0 1.3 2.6 2.3 0.6
Happiness 0.6 0.8 2.4 -0.7 -1.2 -0.6 0.1 -1.2 0.4 1.4 -0.3 1.3 0.4 -0.5 0.1 -0.5 0.1 -1.5 -1.4 0.7
Noisy workplace 0.3 0.4 2.1 -1.4 -1.2 -0.5 -0.2 -0.8 -0.4 0.1 0.1 0.9 0.3 -0.6 -0.4 -0.5 -0.4 -0.4 -0.5 -0.0
Qualifications: A levels/AS levels or equivalent 1.1 2.5 4.5 -2.0 -1.3 -2.0 1.2 -2.1 -1.5 -0.2 -1.5 1.9 1.0 -1.8 -1.3 -1.9 -1.5 -1.8 -1.7 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 2.4 0.4 -1.5 0.5 -1.4 0.6 0.2 -0.5 0.6 -0.7 -1.2 0.2 0.5 0.5 0.3 1.1 1.3 0.1
Mouth/teeth dental problems: Dentures 0.6 1.0 2.4 -1.1 -0.2 -0.9 1.1 -0.1 -1.3 -1.6 -1.0 -0.0 1.0 -0.7 -1.3 -0.8 -1.3 0.3 0.1 -1.5
Asthma 0.1 0.2 0.8 -0.6 -0.9 -0.4 0.0 -0.7 -0.6 -0.3 0.3 0.1 -0.5 -0.1 -0.1 -0.3 -0.5 0.5 0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.7 0.0 -1.6 -0.1 0.5 -0.5 0.4 0.9 -0.0 0.6 -0.1 0.2 0.3 -0.0 0.3 -0.8 -0.7 0.6
Medication: Cholesterol lowering 1.1 1.7 3.1 -1.6 -0.3 -1.8 0.5 -1.3 -1.4 -0.8 -1.7 1.1 1.0 -1.6 -1.3 -1.7 -1.4 -1.3 -1.0 -1.5
Depression (self-reported) 0.3 0.4 4.0 -0.5 -2.0 -0.3 -0.5 -1.0 -0.2 0.0 -0.1 0.1 -0.8 -0.5 0.4 -0.3 -0.1 -0.0 0.2 -0.1
Medication: Lansoprazole 0.9 1.0 2.2 1.3 -0.2 1.1 0.4 0.3 0.6 0.3 1.4 -1.3 -1.2 1.2 1.2 1.2 0.9 1.5 1.2 0.6
Prospective memory result 5.5 6.7 11.8 2.7 0.2 2.9 -1.2 1.9 2.9 1.3 2.7 -2.9 -3.4 2.8 3.4 3.0 2.9 2.6 2.8 2.2
Lung cancer (father) 1.7 2.0 3.9 1.9 -0.4 1.8 -0.8 1.6 1.4 0.4 1.5 -1.5 -1.0 2.0 1.3 1.7 1.5 1.6 1.3 1.1
Illnesses of mother 2.1 2.6 7.7 -2.3 -1.8 -1.1 1.2 -2.8 -0.2 1.9 -0.1 2.4 1.4 -1.2 -0.4 -1.1 -0.2 -2.3 -2.5 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.7 0.2 1.3 -0.5 1.6 -0.2 -0.7 -1.2 -1.2 -0.1 -0.1 -0.4 -0.7 -0.7 -0.8 -0.1 0.3 -1.0
Pulse wave Arterial Stiffness index 0.2 0.3 0.8 -0.4 0.7 -0.3 0.7 0.0 -0.7 -0.9 -0.1 0.0 0.4 -0.5 -0.7 -0.3 -0.7 0.4 0.3 -0.6
Impedance of arm (left) 2.0 9.1 20.1 -4.1 -2.4 -3.9 0.9 -4.5 -3.5 -1.1 -2.5 3.0 1.7 -3.7 -2.6 -3.8 -3.2 -2.5 -2.4 -2.8
Arm fat mass (right) 0.6 2.3 3.9 1.3 1.1 1.7 -1.7 1.0 1.7 1.5 1.8 -1.0 -1.5 1.6 2.0 1.7 1.8 1.0 0.8 1.8
Trunk predicted mass 0.9 5.3 8.9 2.8 2.1 3.0 0.3 2.7 2.9 1.6 2.4 -1.7 -1.4 2.6 2.4 2.9 2.8 1.5 1.4 2.7
Standing height 0.2 1.5 7.6 -1.3 -0.5 -0.9 2.8 -1.5 -0.6 0.6 -0.5 1.7 1.1 -1.2 -0.7 -1.0 -0.6 -1.5 -1.5 -0.1
Length of working week for main job 1.7 1.9 3.9 -1.1 -1.1 -1.6 -1.3 -1.2 -1.8 -1.7 -1.7 0.5 0.6 -1.6 -1.4 -1.7 -1.7 -0.5 -0.2 -2.0
Exposure to tobacco smoke at home 1.8 2.0 3.6 1.9 0.4 1.6 -1.2 1.4 1.5 1.0 1.6 -1.2 -1.2 1.4 1.7 1.7 1.7 1.2 1.1 1.4
Breastfed as a baby 0.3 0.4 1.7 0.2 0.3 -0.3 0.7 0.4 -0.9 -0.9 -0.1 0.1 1.3 -0.5 -1.0 -0.3 -0.7 0.2 -0.1 -0.8
Tense / ‘highly strung’ 0.6 0.9 1.9 -1.4 -0.9 -1.0 -0.8 -1.2 -0.9 -0.1 -0.7 1.1 1.0 -1.0 -0.9 -1.1 -0.8 -1.1 -1.1 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 3.2 -1.3 -1.8 -0.7 -0.1 -1.3 -0.9 -0.2 -0.2 0.6 -0.0 -0.6 -0.4 -0.7 -0.8 -0.2 -0.3 -0.5
Hair/balding pattern: Pattern 4 1.4 3.4 5.2 1.6 1.8 2.0 -1.2 1.1 1.9 1.2 2.2 -1.7 -2.2 2.0 2.3 2.1 2.0 1.8 1.6 1.8
Birth weight of first child 2.0 3.6 8.3 -1.9 0.3 -2.2 0.5 -1.5 -2.9 -2.2 -1.8 1.0 1.8 -1.9 -2.4 -2.1 -2.7 -0.5 -0.7 -2.7
Peak expiratory flow (PEF) 0.2 0.4 3.3 -0.2 -1.8 -0.3 1.3 -0.3 -0.4 -0.6 -0.4 0.1 -0.1 -0.3 -0.3 -0.4 -0.3 0.1 0.2 -0.5
Pulse wave reflection index 0.7 0.8 2.0 -1.1 -0.8 -0.8 0.8 -0.9 -0.4 0.2 -0.7 1.4 1.1 -1.1 -1.0 -0.9 -0.6 -1.4 -1.2 -0.1
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.2 0.8 0.6 0.3 -0.5 0.6 0.3 -0.4 -0.0 -0.9 -1.1 0.8 0.5 0.4 0.2 0.6 0.9 0.0
Loud music exposure frequency 1.8 2.0 5.3 -1.5 -2.3 -0.8 0.5 -2.0 0.2 1.9 -0.4 2.0 0.9 -0.8 0.0 -0.8 0.0 -2.2 -2.3 0.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 6.5 -1.2 -2.5 -0.4 -0.9 -1.3 -0.2 0.6 -0.2 1.2 -0.5 -0.3 -0.0 -0.6 -0.2 -0.8 -0.7 0.3
Mouth/teeth dental problems: Bleeding gums 2.2 2.9 6.2 0.8 -1.7 1.8 -1.2 -0.1 2.1 2.5 2.3 -0.5 -1.4 1.8 2.4 1.8 2.3 0.5 0.2 2.4
Blood clot in the leg (DVT) 0.7 0.8 2.4 0.3 -1.1 1.0 0.7 -0.0 0.6 0.6 1.6 -0.9 -0.8 1.1 1.1 1.1 0.8 1.3 0.8 0.6
Medication: Paracetamol 0.1 0.2 0.7 -0.3 0.1 0.1 0.1 -0.3 0.4 0.8 0.4 0.5 -0.1 0.0 0.3 0.2 0.4 -0.5 -0.4 0.7
Headache pain in last month 2.2 3.7 7.4 -1.7 0.0 -2.3 2.6 -1.4 -2.0 -1.4 -2.7 1.4 1.7 -2.0 -2.2 -2.3 -2.2 -1.8 -1.5 -2.0
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 4.2 1.6 -0.2 1.8 0.3 1.2 2.0 1.7 1.7 -0.7 -0.8 1.6 1.6 1.8 1.8 0.6 0.4 2.0
Glaucoma (self-reported) 0.5 0.6 1.6 0.5 -0.9 0.6 -0.0 0.4 0.9 0.4 0.9 -0.4 -1.3 0.5 0.9 0.7 0.9 0.6 0.9 0.9
Gout (self-reported) 0.3 0.4 1.3 -0.3 -0.6 -0.5 1.0 0.3 -0.8 -1.1 -0.8 -0.5 0.0 -0.2 -0.4 -0.5 -0.7 0.3 0.4 -1.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.3 -0.7 0.8 0.1 -0.9 -0.9 0.8 1.5 0.2 0.8 0.2 -0.1 0.5 0.1 0.8 -1.2 -1.0 1.0
Medication: Amlodipine 0.3 0.5 2.4 0.2 0.6 -0.0 -1.5 1.1 -0.4 -1.2 -0.4 -0.9 -0.3 0.2 -0.2 0.1 -0.3 0.8 0.9 -0.7
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.0 -0.2 -0.5 -0.5 0.8 -0.2 -0.7 -1.0 -0.2 -0.3 -0.4 -0.1 -0.4 -0.4 -0.6 0.6 0.6 -0.8
Birth weight 0.6 1.2 4.8 -0.4 -1.2 -0.6 1.2 0.3 -1.7 -2.2 -0.5 -0.6 0.2 -0.2 -1.1 -0.5 -1.4 1.2 0.9 -1.7
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.7 0.7 0.2 0.4 0.2 0.8 0.3 -0.2 -0.1 -0.7 -0.8 0.7 0.4 0.3 0.3 0.5 0.7 -0.0
High blood pressure (siblings) 0.3 0.5 1.8 0.3 0.0 0.4 -0.7 0.6 0.1 -0.6 0.2 -0.9 -1.3 0.2 0.7 0.4 0.2 1.1 1.4 -0.1
Forced vital capacity (FVC), Best measure 0.1 0.3 2.7 0.5 0.9 0.3 1.6 -0.1 0.4 0.3 0.0 0.0 -0.3 0.4 0.2 0.1 0.3 -0.1 -0.1 0.3
Body fat percentage 0.1 0.5 2.8 0.4 1.1 0.4 -1.7 0.1 0.6 0.7 0.6 -0.1 -0.6 0.5 0.8 0.5 0.7 0.1 0.1 0.7
Leg fat percentage (right) 0.5 1.9 4.9 1.7 2.2 1.4 -1.8 1.7 1.3 0.4 1.0 -1.2 -0.9 1.4 1.2 1.4 1.4 1.0 1.1 1.0
Arm fat-free mass (right) 1.3 6.9 11.8 3.2 2.4 3.4 -0.4 3.3 3.0 1.6 2.9 -2.1 -1.5 3.1 2.5 3.3 3.0 2.0 1.7 2.8
Exposure to tobacco smoke outside home 0.5 0.7 1.6 0.7 -0.3 0.9 -0.6 0.6 0.6 0.2 1.2 -0.9 -0.8 0.7 1.0 1.0 0.8 1.2 1.0 0.6
Comparative body size at age 10 0.6 1.5 7.9 -0.1 -2.8 0.8 -0.6 -0.7 1.2 1.9 1.2 -0.1 -1.4 1.1 1.6 0.9 1.2 -0.0 -0.1 1.5
Number of full brothers 1.0 1.2 3.6 0.8 -0.0 1.0 -0.9 1.9 0.5 -0.8 0.5 -1.9 -1.2 0.9 0.8 1.0 0.5 1.7 1.8 -0.1
Worry too long after embarrassment 1.1 1.9 3.3 -1.8 -1.7 -1.4 -0.6 -1.5 -1.2 0.0 -1.2 1.8 1.6 -1.3 -1.3 -1.6 -1.2 -1.5 -1.7 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 3.6 -0.2 -1.9 0.3 -0.4 -0.4 0.6 0.7 0.1 -0.5 -1.0 0.8 0.8 0.4 0.4 -0.0 0.1 0.5
Wheeze or whistling in the chest in last year 0.3 0.5 1.5 0.5 -0.3 0.7 -0.9 0.1 0.3 0.0 1.2 -0.7 -1.1 0.8 0.7 0.7 0.4 1.2 1.0 0.4
Number of children fathered 1.1 1.2 5.3 0.8 1.5 -0.3 -0.3 1.0 -1.2 -2.3 -0.8 -1.1 -0.2 -0.0 -0.9 -0.4 -1.1 1.3 1.4 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 3.6 -0.6 -1.9 -1.0 0.2 -0.7 -1.5 -1.4 -0.8 0.5 0.5 -1.4 -1.1 -1.1 -1.3 -0.0 0.1 -1.3
Age at first live birth 2.6 4.7 7.6 -2.5 -0.9 -2.6 1.1 -2.1 -2.3 -1.1 -2.6 2.1 1.9 -2.5 -2.4 -2.8 -2.4 -2.2 -2.0 -2.1
Pulse wave peak to peak time 0.2 0.2 0.8 0.4 -0.6 0.2 -0.5 -0.1 0.6 0.9 0.2 0.1 -0.2 0.4 0.6 0.3 0.6 -0.4 -0.3 0.6
Health satisfaction 0.6 0.7 2.7 -0.6 -1.1 0.2 1.4 -0.6 0.6 1.6 0.5 0.8 0.8 0.4 0.5 0.3 0.5 -0.8 -1.3 1.0
Shortness of breath walking on level ground 0.7 0.8 2.3 0.1 0.1 0.9 1.4 0.3 1.2 1.5 1.2 -0.1 -0.1 0.8 1.1 1.0 1.2 0.0 -0.2 1.3
Qualifications: College or University degree 0.2 0.7 1.6 -0.3 -0.8 -1.0 1.2 -1.0 -0.7 -0.4 -1.3 0.6 -0.2 -1.0 -0.5 -1.1 -0.8 -0.9 -0.5 -0.6
Eye problems/disorders: None of the above 0.6 0.7 2.7 -0.5 -0.0 -0.3 0.1 -1.4 0.3 1.7 0.0 1.2 0.3 -0.5 0.4 -0.4 0.2 -1.5 -1.5 0.8
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.9 0.7 0.6 1.0 -1.4 0.4 0.8 0.6 1.4 -1.0 -1.1 1.0 1.2 1.1 0.9 1.1 0.9 0.8
Emphysema/chronic bronchitis 0.5 0.6 1.8 1.0 1.0 0.4 0.9 1.1 -0.2 -1.0 0.3 -1.2 -0.2 0.3 0.1 0.5 -0.0 1.3 1.2 -0.5
Medication for pain relief, constipation, heartburn 0.4 0.7 1.5 -0.8 -0.4 -0.7 0.7 0.0 -1.0 -1.1 -1.0 0.4 1.0 -1.0 -1.2 -0.9 -1.1 -0.3 -0.3 -1.1
Neck or shoulder pain in last month 0.7 1.0 2.1 1.2 0.4 1.3 -0.2 1.4 1.1 0.2 0.8 -1.1 -0.7 1.4 0.8 1.2 1.1 1.0 0.9 0.7
Medication: Blood pressure 0.7 1.2 3.4 -1.1 -0.5 -1.0 -0.7 -0.5 -1.9 -1.7 -0.6 0.1 0.7 -0.9 -1.4 -1.1 -1.6 0.4 0.1 -1.8
Angina (self-reported) 0.1 0.1 0.4 -0.7 0.3 -0.2 -0.1 -0.6 -0.5 0.3 0.6 0.3 0.6 0.0 0.1 -0.1 -0.2 0.4 -0.4 -0.3
Migraine (self-reported) 0.9 1.1 2.7 -1.1 -0.6 -1.4 0.2 -0.7 -1.3 -1.1 -1.6 0.6 0.5 -1.0 -1.2 -1.4 -1.4 -0.7 -0.5 -1.4
Medication: Ibuprofen 0.5 0.6 2.3 -0.3 -1.5 -0.6 1.4 -0.9 0.1 0.8 -0.6 0.9 0.4 -0.1 -0.0 -0.5 0.0 -1.3 -1.2 0.3
Medication: Allopurinol 0.1 0.2 0.7 -0.1 -0.5 -0.3 0.1 0.3 -0.5 -0.9 -0.4 -0.4 -0.1 0.0 -0.3 -0.2 -0.4 0.3 0.4 -0.7
Medication: Omeprazole 0.3 0.4 2.6 -0.1 1.6 -0.5 -1.0 -0.1 -0.4 -0.5 -0.6 -0.3 -0.8 -0.5 0.2 -0.4 -0.4 0.1 0.5 -0.6
Medication: Seretide 50 evohaler 0.1 0.1 0.4 0.0 0.7 -0.1 0.3 -0.5 -0.3 -0.0 0.5 0.3 -0.2 -0.6 0.0 -0.1 -0.2 0.3 0.2 0.0
Mean time to correctly identify matches 1.7 3.3 6.9 1.5 0.2 2.1 -2.3 0.7 1.8 1.1 2.6 -1.4 -1.7 1.9 2.1 2.2 2.1 2.0 1.7 1.8
Heart disease (mother) 1.0 1.2 4.8 0.7 0.2 0.2 -0.5 1.4 -1.0 -2.2 -0.1 -1.5 -0.4 0.3 -0.5 0.2 -0.8 1.9 1.8 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 4.7 -1.5 -1.5 -1.9 2.2 -2.1 -1.7 -0.6 -1.6 1.7 1.1 -1.7 -1.4 -1.9 -1.6 -1.6 -1.5 -1.3
Whole body fat mass 0.3 1.1 1.8 0.9 1.4 1.1 -1.2 0.6 1.2 1.3 1.2 -0.4 -0.7 1.1 1.3 1.1 1.3 0.4 0.2 1.3
Leg fat mass (right) 0.7 2.7 3.7 1.8 1.9 1.8 -1.7 1.7 1.8 1.1 1.6 -1.3 -1.4 1.8 1.8 1.9 1.9 1.1 1.1 1.7
Arm predicted mass (right) 1.5 7.7 13.2 3.4 2.7 3.6 -0.6 3.5 3.2 1.7 3.0 -2.2 -1.6 3.2 2.7 3.5 3.2 2.1 1.9 3.0
Pulse rate, automated reading 0.6 1.9 4.9 1.7 1.1 1.4 -1.5 1.5 0.6 -0.4 1.6 -1.6 -1.2 1.5 0.9 1.5 0.9 2.2 1.8 0.5
Alcohol intake frequency. 0.3 0.7 6.5 -0.7 -2.5 0.2 -1.3 -0.1 -0.3 0.5 0.9 0.6 0.8 0.2 -0.5 0.0 -0.2 0.1 -0.6 0.2
Comparative height size at age 10 0.0 0.3 1.4 -0.0 -0.7 -0.1 1.2 -0.8 0.3 0.5 0.1 0.2 -0.7 -0.3 0.5 -0.0 0.3 -0.4 -0.1 0.5
Number of full sisters 3.6 4.4 7.0 2.0 1.4 2.2 -2.0 1.6 2.2 1.0 2.2 -2.2 -2.6 2.6 2.5 2.4 2.2 2.0 2.0 1.8
Suffer from ‘nerves’ 0.7 1.1 2.8 0.7 -0.9 1.2 -1.4 0.4 1.5 1.6 0.9 -0.0 -0.7 1.1 1.2 1.1 1.3 -0.2 -0.2 1.7
Overall health rating 1.0 2.1 6.8 1.4 -0.0 1.6 -2.6 1.2 1.2 0.9 1.7 -1.3 -1.2 1.9 1.7 1.6 1.3 1.6 1.0 1.0
Chest pain or discomfort 0.2 0.2 2.2 0.6 1.5 0.4 -0.1 0.7 -0.0 -0.0 0.4 -0.1 0.5 0.4 -0.1 0.3 -0.0 0.4 -0.0 -0.0
Had major operations 0.4 0.5 1.6 -0.4 1.1 -0.4 0.5 -0.2 -1.1 -1.3 -0.1 -0.1 0.2 -0.7 -0.6 -0.5 -0.8 0.8 0.6 -1.1
Age at last live birth 2.6 3.7 5.7 -2.3 -0.9 -2.3 0.6 -1.4 -2.4 -1.3 -2.0 1.7 2.3 -2.3 -2.3 -2.2 -2.4 -1.4 -1.6 -2.1
Family relationship satisfaction 0.4 0.5 1.7 -0.1 -1.3 0.1 -0.1 -0.4 0.7 1.3 0.4 0.8 0.5 0.2 0.2 0.2 0.5 -1.0 -1.0 1.0
Leg pain on walking 0.6 0.7 5.3 -1.2 -2.3 -0.6 0.4 -0.8 -0.4 0.2 -0.3 1.0 0.8 -0.7 -0.7 -0.6 -0.5 -0.8 -0.9 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 2.7 -0.4 -1.6 0.3 -0.9 0.1 0.3 0.2 0.4 -0.3 -0.9 0.3 0.6 0.3 0.4 0.4 0.5 0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.8 -0.9 0.0 -0.9 1.0 -0.6 -0.5 -0.2 -1.3 1.1 0.8 -0.8 -1.0 -1.1 -0.7 -1.3 -1.0 -0.5
Illness, injury, bereavement, stress in last 2 years 3.0 3.7 9.0 -2.0 0.6 -1.8 3.0 -2.0 -0.8 0.9 -1.6 2.7 2.2 -2.0 -1.3 -1.7 -1.0 -2.9 -2.8 -0.1
Medication: Aspirin 1.7 2.2 4.0 1.8 1.1 1.6 -1.2 1.7 1.1 -0.0 1.4 -2.0 -1.5 1.8 1.4 1.6 1.3 2.0 1.8 0.5
Supplements: Vitamin C 2.9 3.5 15.0 -2.5 -3.9 -1.4 0.5 -2.8 -1.0 1.2 -0.4 2.6 1.5 -1.4 -0.9 -1.4 -0.9 -2.1 -2.5 0.0
Knee pain experienced in last month 0.1 0.2 0.9 -0.7 -0.9 0.1 -0.5 -0.0 -0.1 0.3 0.2 0.6 0.8 -0.1 -0.4 -0.0 -0.1 -0.3 -0.6 0.2
Hypertension (Self-reported) 0.3 0.7 6.4 0.6 0.3 0.5 -2.5 0.3 0.3 0.1 0.9 -0.5 -1.0 0.6 0.7 0.6 0.4 0.8 0.8 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.9 -2.1 -1.5 -1.3 0.6 -2.2 -1.4 0.1 -0.3 1.2 0.6 -1.1 -0.5 -1.2 -1.1 -0.6 -1.0 -0.9
Illnesses of father: Heart disease 0.5 0.7 7.2 0.2 0.8 0.5 -2.7 0.9 0.1 -0.2 0.3 -0.8 -0.4 0.6 0.3 0.5 0.2 0.8 0.6 -0.0
Illnesses of siblings: Diabetes 1.2 1.5 5.3 -0.7 0.8 -0.8 0.6 -1.1 0.1 1.5 -0.5 1.9 2.0 -1.1 -0.6 -0.8 -0.2 -2.2 -2.3 0.5
Smoking status: Previous 0.1 0.1 1.0 0.8 -0.0 -0.2 1.0 0.0 0.1 -0.2 -0.4 0.1 0.2 -0.4 -0.2 -0.2 -0.0 -0.4 -0.1 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 1.0 1.0 0.2 0.3 0.8 0.6 0.2 -0.3 -0.2 -0.3 -0.4 0.3 0.1 0.2 0.1 0.2 0.4 0.1
Whole body fat-free mass 0.9 5.3 8.8 2.7 2.2 3.0 -0.0 2.6 2.8 1.8 2.5 -1.7 -1.5 2.7 2.5 2.9 2.8 1.5 1.4 2.7
Leg fat-free mass (right) 0.7 3.6 5.8 1.9 1.6 2.4 -0.5 1.6 2.4 2.0 2.3 -1.2 -1.3 2.2 2.3 2.4 2.4 1.0 0.7 2.4
Arm fat percentage (left) 0.3 1.0 4.0 0.6 1.1 0.9 -2.0 0.3 0.9 1.0 1.1 -0.6 -1.1 1.0 1.3 0.9 1.1 0.6 0.4 1.0
Average weekly red wine intake 0.1 0.2 1.1 0.1 1.0 -0.1 0.4 -0.6 0.4 0.5 0.1 0.5 -0.4 -0.2 0.1 -0.1 0.2 -0.5 -0.2 0.6
Handedness (chirality/laterality): Left-handed 0.4 0.5 4.5 0.2 0.3 0.5 -2.1 1.0 -0.0 -0.7 0.4 -0.7 -0.3 0.5 -0.1 0.4 -0.0 0.9 0.8 -0.1
Mood swings 0.8 1.4 2.6 -0.7 -0.3 -1.4 0.4 -1.0 -1.3 -0.8 -1.6 1.0 1.5 -1.4 -1.5 -1.5 -1.3 -1.1 -1.1 -1.3
Loneliness, isolation 1.2 1.7 6.8 1.7 -2.6 1.2 -0.8 1.5 1.0 -0.4 0.4 -1.4 -1.5 1.2 0.9 1.2 0.9 1.3 1.6 0.6
Long-standing illness, disability or infirmity 0.2 0.4 1.1 0.3 -0.2 0.2 -0.9 0.8 -0.0 -0.7 0.1 -0.9 -0.9 0.3 0.3 0.3 -0.0 1.0 1.1 -0.3
Ever had bowel cancer screening 0.4 0.4 1.8 0.5 -0.1 0.3 -1.3 0.1 0.0 -0.4 0.7 -0.5 -1.2 0.0 0.5 0.3 0.2 1.0 1.2 0.1
Diabetes diagnosed by doctor 0.3 0.5 1.9 -0.1 0.1 -0.7 1.0 -0.7 0.0 0.4 -0.8 0.9 0.4 -0.9 -0.2 -0.7 -0.2 -1.4 -0.9 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 4.4 1.1 1.6 0.1 -0.3 2.1 -0.7 -2.1 -0.5 -1.4 -0.1 0.6 -0.9 0.1 -0.7 1.4 1.4 -1.2
Friendships satisfaction 1.1 1.3 4.7 0.5 -0.8 1.0 -2.2 0.0 1.3 1.5 1.4 -0.3 -1.1 1.3 1.4 1.1 1.3 0.4 0.2 1.4
Qualifications: nursing, teaching 0.7 1.1 7.3 -0.2 -2.7 0.3 -0.1 -1.5 0.6 1.6 1.2 0.7 -0.9 0.2 1.0 0.4 0.8 -0.3 -0.4 1.3
Commuting to job workplace: Walk 0.9 0.9 2.8 -0.8 0.1 -0.3 1.1 -1.1 0.4 1.7 0.3 1.5 1.1 -0.8 0.0 -0.2 0.3 -1.6 -1.6 0.9
Eye problems/disorders: Cataract 0.2 0.3 1.4 -0.5 0.6 -0.3 0.1 -0.0 -0.6 -0.3 -0.1 0.5 1.2 -0.3 -0.7 -0.3 -0.5 0.0 -0.4 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.4 -0.0 -0.2 -0.1 0.4 -0.1 -0.0 -0.4 0.1 0.1 -0.2 -0.6 0.1 -0.0 0.1 0.4 0.6 -0.1
Medication for cholesterol 4.2 6.3 10.7 -2.9 0.3 -2.7 1.8 -1.5 -3.2 -2.1 -2.7 1.7 3.2 -2.4 -3.3 -2.9 -3.2 -1.4 -1.9 -3.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.3 -1.2 0.0 -0.5 -0.5 -0.9 -0.6 0.4 -0.1 0.8 0.9 -0.1 -0.6 -0.6 -0.6 -0.6 -1.1 -0.3
Back pain experienced in last month 0.4 0.5 1.9 0.4 1.0 0.5 -0.2 0.2 1.0 1.4 0.3 0.5 0.2 0.7 0.6 0.5 0.8 -0.7 -0.8 1.2
Mineral and other dietary supplements 2.5 3.4 13.5 2.3 1.2 1.4 -3.7 2.7 0.8 -1.0 0.6 -2.4 -1.9 1.7 0.9 1.4 0.7 2.1 2.3 0.2
Breast cancer (self-reported) 0.4 0.5 2.0 -0.7 1.4 -0.6 -1.1 -0.2 -1.0 -1.0 -0.7 -0.1 0.1 -0.3 -0.5 -0.5 -0.8 0.3 0.2 -1.0
Asthma (self-reported) 0.1 0.3 0.9 -0.4 -0.9 -0.1 -0.3 -0.5 -0.5 -0.5 0.5 -0.3 -0.8 0.2 0.1 -0.0 -0.4 0.9 0.7 -0.4
Osteoporosis (self-reported) 5.7 7.1 15.4 2.6 -2.7 2.7 -2.3 1.5 2.5 1.0 2.9 -2.4 -3.9 2.6 3.2 2.8 2.7 2.8 3.0 2.3
Osteoarthritis (self-reported) 0.3 0.4 1.5 -0.5 -0.8 0.3 1.2 -0.2 0.1 0.8 1.1 0.4 0.9 0.0 0.2 0.4 0.3 0.1 -0.5 0.6
Medication: Aspirin 2.1 2.7 4.4 2.0 1.3 1.8 -1.4 1.6 1.2 0.2 1.7 -2.0 -1.8 1.9 1.7 1.8 1.5 2.1 1.9 0.8
Medication: Gliclazide 0.5 0.5 1.3 -1.1 -0.9 -0.7 -0.3 -0.6 -0.9 -0.4 -0.2 0.6 1.0 -0.9 -0.9 -0.7 -0.8 -0.3 -0.5 -0.7
Illnesses of father: None of the above (group 1) 0.3 0.3 1.6 0.3 -1.3 0.6 1.1 -0.2 0.3 0.4 0.9 -0.1 0.1 0.3 0.4 0.5 0.4 0.4 0.1 0.4
Smoking status: Current 0.5 0.8 2.9 1.6 1.7 0.7 -0.6 1.7 0.7 -0.4 -0.3 -1.1 -0.1 0.6 0.3 0.6 0.5 0.5 0.8 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.3 9.5 -1.4 0.4 -2.4 0.9 -1.1 -2.8 -2.8 -3.1 0.8 0.6 -2.0 -2.6 -2.7 -2.9 -1.0 -0.4 -3.0
Whole body water mass 1.0 5.5 9.0 2.8 2.3 3.0 -0.1 2.7 2.8 1.7 2.5 -1.8 -1.5 2.7 2.5 3.0 2.8 1.6 1.4 2.6
Leg predicted mass (right) 0.7 3.6 5.7 1.9 1.7 2.4 -0.4 1.7 2.4 2.0 2.2 -1.1 -1.2 2.2 2.3 2.3 2.4 1.0 0.7 2.4
Arm fat mass (left) 0.6 2.4 3.6 1.5 1.5 1.7 -1.7 1.2 1.7 1.3 1.7 -1.2 -1.5 1.7 1.9 1.7 1.8 1.1 1.0 1.6
Number of self-reported non-cancer illnesses 0.6 1.1 3.3 0.4 0.6 0.9 -1.4 0.5 0.3 -0.2 1.6 -1.0 -1.6 0.9 1.0 1.0 0.5 1.8 1.6 0.4
Average weekly champagne plus white wine intake 0.7 0.9 2.5 -0.2 1.6 -1.0 1.5 -0.3 -0.6 -0.8 -1.6 0.8 0.3 -1.1 -0.9 -1.1 -0.8 -1.0 -0.4 -0.7
Miserableness 0.5 0.9 3.0 -0.4 -1.7 -1.0 1.6 -1.5 -0.4 0.2 -0.8 1.1 0.4 -0.9 -0.5 -0.8 -0.4 -1.2 -0.9 -0.1
Guilty feelings 0.5 0.8 5.6 -0.1 -2.4 0.5 -0.8 -0.7 0.9 1.1 0.8 0.3 -0.6 0.4 0.8 0.5 0.9 -0.2 -0.1 1.1
Wears glasses or contact lenses 0.2 0.2 1.1 0.4 0.1 0.0 0.7 0.3 -0.2 -0.4 -0.1 0.2 1.1 -0.1 -0.8 0.0 -0.2 -0.1 -0.2 -0.1
Ever taken oral contraceptive pill 0.7 0.8 4.5 0.3 0.8 -0.7 2.1 0.5 -0.5 -1.5 -1.3 -0.5 -0.2 -0.8 -0.6 -0.6 -0.6 0.1 0.7 -1.1
Hearing aid user 0.5 0.6 1.5 -0.9 1.2 -0.8 0.3 -0.2 -1.1 -1.0 -0.8 0.3 0.5 -0.5 -1.0 -0.8 -1.1 -0.1 -0.1 -1.1
Mother’s age at death 2.6 3.2 6.0 1.5 0.2 2.0 -0.1 1.0 2.4 1.9 2.2 -1.3 -2.0 1.9 2.5 2.1 2.4 1.0 1.1 2.3
Financial situation satisfaction 1.5 1.8 4.5 1.4 0.0 1.3 -1.2 0.1 2.1 2.1 1.0 -0.3 -1.3 1.6 1.7 1.3 1.8 -0.3 -0.1 2.0
Tinnitus: Yes, now most or all of the time 1.0 1.1 3.5 -1.0 -0.9 -1.1 0.6 -1.1 -0.5 0.4 -1.2 1.5 0.8 -1.1 -0.9 -1.2 -0.7 -1.9 -1.6 -0.2
Commuting to job workplace: Public transport 1.2 1.4 3.0 1.7 -0.4 1.5 -0.0 0.7 1.0 0.4 1.7 -1.2 -1.0 1.2 1.3 1.5 1.3 1.5 1.3 1.0
Eye problems/disorders: Glaucoma 1.6 1.9 3.4 1.4 0.2 1.4 -0.8 1.4 1.2 0.2 1.5 -1.6 -1.9 1.3 1.5 1.5 1.3 1.8 1.8 1.0
Medication: Blood pressure 2.2 4.2 8.6 2.3 -0.2 2.0 -2.9 1.6 2.0 0.8 2.2 -1.8 -2.6 1.9 2.3 2.3 2.1 1.8 2.1 2.0
Pain type(s) experienced in last month: Hip pain 1.3 1.7 2.7 1.4 -0.6 1.3 -1.6 1.5 1.0 -0.0 1.3 -1.5 -1.4 1.5 1.1 1.4 1.0 1.6 1.6 0.8
Supplements: Fish oil (including cod liver oil) 2.2 2.9 9.0 -2.6 -1.4 -1.2 2.5 -3.0 -0.9 1.2 -0.1 2.4 1.9 -1.4 -0.8 -1.2 -0.6 -1.8 -2.2 -0.1
High cholesterol (Self-reported) 0.4 0.7 2.0 -1.4 -1.2 -0.9 -0.2 -1.1 -0.6 0.3 -0.4 1.1 0.5 -1.1 -0.4 -0.9 -0.6 -1.0 -0.9 -0.3
Medication: Bendroflumethiazide 0.7 1.1 6.0 -0.1 -0.3 0.5 -2.4 -0.7 1.0 1.6 1.0 0.4 -1.3 0.6 1.3 0.6 0.9 -0.3 -0.2 1.4
Medication: Paracetamol 0.1 0.2 0.5 0.1 -0.1 0.2 -0.1 0.0 0.6 0.7 0.4 -0.1 -0.6 0.3 0.7 0.4 0.6 -0.1 0.1 0.7
Medication: Lisinopril 0.7 0.9 1.9 -0.9 -0.9 -1.2 1.0 -0.8 -1.3 -1.1 -0.7 0.7 0.2 -1.4 -0.9 -1.1 -1.1 -0.3 -0.0 -1.0
Medication: Atorvastatin 0.8 0.9 4.2 -0.0 0.3 -0.4 -1.1 0.8 -1.0 -2.0 -0.9 -0.9 -0.7 -0.4 -0.5 -0.4 -0.9 1.1 1.4 -1.4
Illnesses of father: High blood pressure 0.6 0.8 4.2 0.4 -0.3 -0.2 -2.0 0.3 -0.4 -1.2 -0.5 -0.9 -1.5 0.2 0.2 -0.1 -0.4 0.9 1.3 -0.7
Alcohol drinker status: Never 0.4 0.5 1.2 -0.5 0.6 -0.8 0.6 0.1 -0.8 -0.8 -1.1 0.1 0.7 -0.3 -0.9 -0.8 -1.0 -0.3 -0.4 -1.1
Ever smoked 0.1 0.2 1.2 1.1 0.2 0.3 0.4 1.0 0.4 -0.3 -0.1 -0.5 0.1 0.2 -0.0 0.4 0.2 0.1 0.3 0.1
Basal metabolic rate 0.8 4.7 7.5 2.4 2.1 2.7 -0.4 2.3 2.6 1.8 2.4 -1.6 -1.5 2.5 2.4 2.7 2.6 1.4 1.2 2.5
Leg fat percentage (left) 0.5 1.8 4.3 1.6 2.0 1.4 -2.1 1.6 1.2 0.4 1.1 -1.3 -0.9 1.4 1.2 1.4 1.3 1.2 1.1 0.9
Arm fat-free mass (left) 1.3 6.6 11.1 3.2 2.3 3.3 -0.8 3.3 2.8 1.3 2.7 -2.3 -1.7 3.0 2.5 3.2 2.8 2.3 2.0 2.5
Number of operations (self-reported) 1.0 1.5 4.3 0.4 -0.2 1.5 -0.6 0.2 1.1 1.1 2.1 -0.9 -1.4 1.5 1.7 1.5 1.3 1.5 1.0 1.2
Average weekly beer plus cider intake 0.2 0.3 0.8 0.5 -0.5 0.1 -0.2 0.7 -0.3 -0.9 -0.3 -0.8 -0.1 -0.2 -0.1 -0.1 -0.3 0.7 0.7 -0.8
Irritability 0.8 1.4 3.6 -1.3 -0.2 -0.9 1.8 -1.4 -0.2 1.1 -0.3 1.9 1.4 -0.8 -0.6 -0.8 -0.2 -1.8 -1.9 0.3
Risk taking 6.8 9.9 19.1 3.8 -0.8 3.4 -1.8 2.7 2.6 0.1 3.0 -4.0 -4.4 3.6 3.4 3.5 2.8 4.0 4.1 1.9
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.6 0.2 -0.6 0.5 -0.1 0.7 -0.1 -0.5 0.6 -0.9 -1.1 0.6 0.4 0.6 0.1 1.3 1.1 0.1
Fractured/broken bones in last 5 years 0.9 1.1 2.1 -1.1 -1.1 -1.3 0.8 -1.0 -1.4 -1.1 -1.4 0.4 0.1 -0.8 -1.1 -1.4 -1.4 -0.6 -0.3 -1.5
Age started oral contraceptive pill 0.6 0.8 2.2 0.5 0.0 1.0 -1.0 0.4 0.9 0.6 1.5 -0.6 -0.9 0.5 1.2 1.1 1.1 1.1 1.0 0.9
Diastolic blood pressure, automated reading 9.3 28.9 43.2 5.5 1.6 6.3 -4.2 4.5 6.3 4.1 6.1 -4.4 -5.7 6.4 6.6 6.5 6.4 4.2 4.0 6.0
Ever depressed for a whole week 0.1 0.2 0.4 -0.0 -0.5 0.2 0.0 -0.2 0.6 0.6 0.2 -0.0 -0.7 0.0 0.6 0.3 0.4 -0.2 0.1 0.6
Unable to work because of sickness or disability 0.3 0.4 1.6 1.1 0.6 0.7 1.1 1.3 0.4 -0.2 0.2 -0.7 0.1 0.8 0.2 0.6 0.4 0.6 0.4 0.2
Commuting to job workplace: Cycle 0.6 0.8 1.8 0.4 -0.8 0.8 -0.4 0.4 0.7 0.1 1.0 -1.1 -1.2 0.9 1.0 1.0 0.7 1.4 1.2 0.5
Myopia 0.4 0.6 2.5 -0.2 -1.6 0.1 -0.3 -0.9 0.7 1.4 0.5 0.9 0.2 -0.1 0.4 0.1 0.7 -0.9 -0.9 1.0
Vascular/heart problems diagnosed by doctor 0.6 1.7 8.4 -1.1 -0.2 -1.0 2.9 -1.0 -0.4 0.2 -1.3 1.4 1.6 -1.2 -1.2 -1.1 -0.6 -1.8 -1.6 -0.4
Cholesterol lowering medication 0.2 0.3 1.6 0.0 -1.2 0.1 -0.3 -0.4 0.4 0.6 0.3 0.3 -1.0 0.0 0.6 0.2 0.4 -0.2 0.1 0.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 3.3 -0.2 1.8 -0.6 -0.7 -0.2 -0.6 -0.8 -0.5 -0.4 -0.5 -0.6 0.0 -0.5 -0.5 0.4 0.6 -0.9
Pain experienced in last month 0.3 0.5 1.9 0.4 0.4 0.3 -0.5 0.3 -0.2 -0.7 0.7 -1.0 -1.1 0.2 0.5 0.4 0.1 1.4 1.3 -0.4
Supplements: Calcium 1.6 1.7 5.0 0.2 -0.8 1.5 -0.7 -0.2 1.7 2.2 2.1 0.1 -0.5 1.0 1.8 1.5 1.8 0.3 -0.1 2.1
Basal cell carcinoma (self-reported) 2.0 2.3 4.0 -2.0 -1.9 -1.8 1.1 -1.2 -1.9 -1.3 -1.6 1.1 1.2 -1.9 -1.5 -1.7 -1.8 -0.8 -0.7 -1.7
Heart attack/myocardial infarction (self-reported) 0.2 0.3 3.1 -0.1 1.8 -0.3 -0.3 -0.3 -0.1 0.1 -0.3 0.5 0.7 -0.8 -0.2 -0.4 -0.1 -0.5 -0.4 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 3.4 0.9 -0.8 1.5 0.1 0.6 1.0 0.6 1.9 -1.5 -1.3 1.6 1.5 1.6 1.2 1.8 1.3 0.9
Heart disease (siblings) 0.3 0.3 1.8 -1.4 -0.8 -0.5 -0.0 -0.8 -0.2 0.5 -0.3 0.6 0.3 -0.4 -0.0 -0.5 -0.2 -0.7 -0.8 -0.1
Alcohol drinker status: Previous 0.6 0.7 2.7 0.8 -0.6 0.6 -1.7 1.4 -0.3 -1.0 0.5 -1.0 -0.1 0.5 -0.2 0.6 -0.2 1.5 1.1 -0.4
Pack years of smoking 0.4 0.6 1.9 0.8 0.3 0.4 -0.8 0.9 -0.4 -1.1 0.5 -1.2 -0.2 0.4 -0.1 0.5 -0.2 1.4 1.2 -0.5
Impedance of whole body 1.8 9.2 15.7 -3.8 -2.4 -3.9 1.4 -4.0 -3.6 -1.6 -2.9 2.8 1.8 -3.6 -2.9 -3.8 -3.4 -2.3 -2.2 -3.1
Leg fat mass (left) 0.7 2.5 3.5 1.7 1.8 1.8 -1.7 1.6 1.8 1.2 1.7 -1.2 -1.3 1.8 1.8 1.8 1.9 1.1 1.0 1.7
Arm predicted mass (left) 1.4 7.0 11.5 3.1 2.0 3.4 -0.5 3.2 3.0 1.6 2.9 -2.3 -1.9 3.1 2.7 3.4 3.0 2.2 1.9 2.8