Hub : Genes

STEAP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1340	0.0330	6.8e-11	0.118	0.105	0.125	0.117	0.124	3.6e-14	9.7e-13	6.3e-15	4.3e-14	7.7e-15
2	GTEx	Brain Cortex	0.4140	0.1010	1.6e-04	0.009	NA	0.066	NA	0.036	1.8e-01	NA	7.0e-03	NA	3.6e-02
3	GTEx	Esophagus Mucosa	0.2980	0.0510	0.0e+00	0.418	NA	0.403	NA	0.326	4.7e-30	NA	9.7e-29	NA	2.2e-22
4	GTEx	Pancreas	0.1530	0.0580	1.9e-03	-0.003	NA	0.036	NA	0.004	4.7e-01	NA	1.2e-02	NA	2.1e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.1000	0.0254	4.1e-12	0.078	0.109	0.118	0.110	0.121	3.2e-10	8.0e-14	6.9e-15	5.5e-14	2.8e-15
6	TCGA	Breast Invasive Carcinoma	0.0143	0.0091	1.2e-03	0.003	0.007	0.005	NA	0.004	5.9e-02	1.1e-02	2.2e-02	NA	4.2e-02
7	TCGA	Colon Adenocarcinoma	0.0430	0.0300	8.9e-03	0.032	0.038	0.021	NA	0.034	5.8e-03	2.9e-03	2.1e-02	NA	4.6e-03
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0505	0.0262	5.7e-06	0.050	0.054	0.063	NA	0.054	2.4e-06	1.1e-06	1.5e-07	NA	1.1e-06
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0253	0.0157	5.4e-03	0.015	0.016	0.018	NA	0.011	7.5e-03	6.1e-03	3.4e-03	NA	1.8e-02
10	TCGA	Liver Hepatocellular Carcinoma	0.1390	0.0840	3.0e-04	0.030	0.059	0.064	NA	0.050	1.4e-02	9.7e-04	6.0e-04	NA	2.1e-03
11	TCGA	Lung Adenocarcinoma	0.0264	0.0154	8.9e-04	0.038	0.025	0.030	NA	0.035	2.8e-05	5.9e-04	1.6e-04	NA	5.6e-05
12	TCGA	Lung Squamous Cell Carcinoma	0.0376	0.0207	4.2e-05	0.027	0.031	0.015	NA	0.026	4.2e-04	1.8e-04	6.6e-03	NA	5.4e-04
13	TCGA	Ovarian Serous Cystadenocarcinoma	0.0620	0.0380	3.2e-04	0.038	0.047	0.038	NA	0.040	1.2e-03	3.7e-04	1.3e-03	NA	1.0e-03
14	TCGA	Pancreatic Adenocarcinoma	0.0890	0.0510	9.2e-04	0.022	0.006	-0.004	NA	0.009	4.1e-02	1.7e-01	5.1e-01	NA	1.3e-01
15	TCGA	Prostate Adenocarcinoma	0.0331	0.0201	2.3e-03	0.014	0.024	0.018	NA	0.020	1.2e-02	1.3e-03	4.9e-03	NA	3.5e-03
16	TCGA	Stomach Adenocarcinoma	0.0520	0.0330	2.5e-03	0.008	0.043	0.033	NA	0.032	7.8e-02	4.2e-04	1.8e-03	NA	2.1e-03
17	TCGA	Thyroid Carcinoma	0.0220	0.0140	4.7e-03	0.009	0.013	0.001	NA	0.006	3.9e-02	1.8e-02	2.2e-01	NA	7.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Bipolar Disorder (2018)	0.4	0.6	2.4	-0.3	-1.6	0.7	-1.4	-0.5	0.4	0.7	1.4	0.1	-0.2	0.7	0.5	0.7	0.5	0.7	0.1	0.8
Bipolar Disorder or Schizophrenia	0.8	2.0	4.1	0.8	-1.0	1.6	-2.0	0.4	1.4	1.3	2.0	-0.8	-1.6	1.7	1.6	1.7	1.5	1.2	0.9	1.7
Depressed Affect (Nagel 2018)	0.4	0.8	2.2	-0.2	-1.4	-1.1	0.8	-0.8	-0.9	-0.8	-1.5	0.3	0.4	-0.7	-0.9	-1.1	-1.0	-0.7	-0.4	-1.2
Depression (Nagel 2018)	1.7	2.5	5.5	1.5	0.6	1.8	-1.2	0.5	2.3	2.1	1.8	-0.7	-1.5	1.7	2.1	1.7	2.0	0.5	0.5	2.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	5.8	0.2	-1.2	0.8	-2.4	0.8	0.5	0.2	0.8	-0.5	-0.6	0.6	0.6	0.8	0.6	0.8	0.7	0.6
Neuroticism (Nagel 2018)	0.3	0.6	4.5	-0.8	-2.1	-0.3	0.0	-1.3	0.2	1.0	-0.1	0.8	0.3	-0.2	0.1	-0.4	0.2	-1.0	-1.0	0.3
Schizophrenia (2018)	0.9	1.9	3.6	1.3	0.1	1.5	-1.5	0.8	1.5	1.1	1.5	-1.2	-1.9	1.6	1.7	1.6	1.6	1.0	1.0	1.6
Schizophrenia vs Biploar Disorder	0.3	0.4	3.0	0.3	1.7	0.1	0.7	0.5	0.4	0.7	-0.2	0.6	0.6	-0.0	-0.0	0.0	0.4	-0.9	-0.8	0.5
Worry (Nagel 2018)	0.2	0.5	1.7	-0.9	-1.3	-0.2	-1.0	-0.8	0.1	1.0	0.0	0.9	0.6	0.2	-0.1	-0.2	0.0	-0.9	-1.2	0.4
Alzheimer’s Disease (in mother)	0.7	0.8	2.5	0.4	1.0	0.2	-1.4	0.7	-1.0	-1.5	0.3	-1.0	-0.2	-0.1	-0.4	0.1	-0.8	1.6	1.3	-1.1
Alzheimer’s Disease (in father)	2.7	3.0	4.8	-2.0	-0.1	-2.2	0.8	-1.7	-1.7	-0.7	-2.1	1.7	1.5	-1.9	-1.8	-2.2	-1.9	-2.0	-1.7	-1.6
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	-0.7	0.8	-0.8	-0.9	-0.4	-1.4	-1.2	-0.6	0.3	0.7	-1.1	-1.0	-0.9	-1.4	0.2	0.0	-1.2
Crohns Disease (2017)	0.6	1.3	3.7	1.1	1.3	0.5	-1.2	1.8	-0.1	-1.6	0.1	-1.9	-0.8	0.9	-0.0	0.5	0.0	1.7	1.8	-0.8
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	0.8	0.2	0.4	-0.8	1.1	0.0	-0.8	0.2	-1.0	-0.7	0.5	-0.0	0.3	0.0	0.9	1.0	-0.2
Ulcerative Colitis (UC)	0.0	0.1	0.4	0.2	-0.6	0.2	-0.3	0.0	0.3	0.3	0.2	0.2	-0.5	0.0	0.1	0.0	0.1	-0.2	-0.1	0.5
Major Depression (MDD)	0.4	0.5	4.1	-0.8	-2.0	-0.4	-1.5	-0.7	-0.5	-0.0	-0.0	0.3	-0.0	0.2	-0.3	-0.3	-0.4	-0.1	-0.3	-0.3
Reaction Time	2.3	4.5	9.1	1.7	0.4	2.5	-2.6	0.8	2.3	1.8	3.0	-1.5	-1.8	2.4	2.5	2.6	2.5	1.9	1.4	2.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	3.2	0.2	-0.4	0.4	-1.8	0.7	0.2	-0.1	0.1	-0.1	0.2	0.2	-0.1	0.3	0.2	0.1	0.1	0.3
Breast Cancer	0.2	0.5	3.9	0.7	0.1	0.4	2.0	-0.2	0.6	1.2	0.6	0.1	0.3	0.3	0.7	0.5	0.6	-0.4	-0.6	0.8
Ovarian Cancer	0.7	0.9	3.3	-0.3	1.0	0.2	0.7	-0.9	1.0	1.8	0.3	1.2	1.0	-0.2	0.3	0.1	0.9	-1.5	-1.5	1.2
Prostate Cancer	1.0	1.5	4.4	1.3	1.6	1.4	0.1	2.1	0.8	-0.4	0.9	-1.7	-0.7	1.2	0.8	1.4	0.8	1.7	1.5	0.4
Age at First Birth	3.3	4.8	7.1	-2.4	-1.0	-2.5	1.3	-1.8	-2.6	-1.3	-2.2	2.4	2.3	-2.4	-2.7	-2.7	-2.6	-1.8	-1.9	-2.2
Bipolar Disorder (2011)	2.2	2.1	3.9	-2.0	-0.5	-1.6	0.1	-0.9	-2.0	-1.2	-1.2	1.3	1.9	-1.4	-1.9	-1.6	-1.8	-0.7	-1.1	-1.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.5	-0.2	-0.5	-0.1	0.5	-0.1	-0.2	0.1	0.1	0.3	0.7	-0.3	-0.3	-0.1	-0.2	-0.3	-0.4	-0.0
Coronary Artery Disease (CAD)	0.2	0.2	0.6	-0.5	-0.8	-0.3	0.6	-0.1	-0.4	0.2	-0.0	0.8	0.7	-0.5	-0.3	-0.4	-0.3	-0.4	-0.6	-0.1
Crohns Disease (2012)	0.7	1.0	2.7	0.8	0.2	1.1	-1.7	1.4	0.6	-0.1	1.0	-1.5	-0.6	1.4	0.7	1.1	0.8	1.4	1.0	0.3
Mean Putamen Volume	1.1	1.3	5.1	0.6	-0.1	0.5	-0.6	2.0	-0.7	-2.2	-0.0	-1.6	-0.1	0.3	-0.7	0.3	-0.7	1.8	1.8	-1.1
Fasting Glucose	6.2	7.4	13.5	-2.9	0.0	-3.6	0.7	-3.2	-2.6	-1.0	-3.7	3.1	1.8	-3.2	-2.7	-3.5	-2.7	-3.3	-2.6	-2.2
HbA1C	0.9	1.0	4.9	-0.5	0.9	-0.8	2.2	-0.9	-0.8	-0.1	-0.7	0.9	1.5	-0.7	-0.8	-0.8	-0.7	-0.8	-1.1	-0.7
HDL Cholesterol	0.3	0.6	1.9	0.1	1.4	0.8	-0.9	0.6	0.9	1.0	0.7	0.8	1.1	-0.1	-0.0	0.5	0.3	-0.6	-0.6	1.0
LDL Cholesterol	0.5	0.8	2.2	1.3	0.8	1.3	0.0	1.5	1.0	0.0	0.8	-1.0	-0.5	0.7	0.6	1.1	0.2	0.9	1.0	0.8
Lupus	1.7	2.5	9.8	-1.8	-3.1	-1.5	2.4	-2.0	-0.9	-0.0	-1.2	1.4	1.1	-1.4	-1.1	-1.6	-1.0	-1.6	-1.5	-0.9
Neuroticism (2016)	0.1	0.2	1.5	-0.6	-1.2	0.1	-0.6	-0.3	0.3	0.4	0.3	0.1	-0.5	-0.0	0.5	0.1	0.3	0.2	0.2	0.3
Primary Biliary Cirrhosis	0.3	0.4	1.1	0.8	0.1	0.7	0.1	0.8	0.3	-0.2	0.7	-1.1	-0.7	0.8	0.6	0.7	0.4	1.0	0.9	0.1
Rheumatoid Arthritis	0.2	0.2	1.4	0.2	-0.7	0.0	-1.2	0.0	0.0	-0.3	0.1	-0.4	-0.8	-0.1	0.3	-0.0	0.1	0.5	0.7	-0.2
Schizophrenia (2014)	1.1	2.3	4.1	1.5	-0.3	1.7	-1.7	1.0	1.6	1.1	1.6	-1.3	-2.0	1.8	1.8	1.7	1.7	1.3	1.2	1.6
Triglycerides	0.2	0.3	1.3	-0.3	-1.1	-0.7	0.5	-0.7	-0.0	0.3	-0.6	0.8	-0.5	-0.5	-0.1	-0.7	-0.2	-0.9	-0.5	0.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	-1.6	-0.8	-0.9	0.9	-0.9	-1.1	-0.2	-0.4	1.1	1.0	-0.9	-1.1	-1.0	-1.1	-0.7	-1.0	-0.7
Ulcerative Colitis	0.3	0.5	1.2	-0.4	-0.7	-0.6	-0.4	0.3	-0.7	-1.1	-1.1	0.2	0.1	-0.8	-0.9	-0.8	-0.9	-0.3	0.0	-0.8
Blood Eosinophil Count	0.2	1.3	3.0	-1.4	-0.8	-1.0	1.2	-1.4	-1.4	-0.9	-0.5	1.1	1.5	-1.7	-1.3	-1.1	-1.2	-0.5	-0.6	-1.1
Blood Platelet Count	0.1	0.6	2.1	-1.1	-0.9	-0.6	-0.7	-1.4	-0.5	0.2	-0.5	1.1	0.0	-0.9	-0.3	-0.9	-0.5	-0.9	-0.8	-0.2
Blood Red Count	0.1	1.0	7.6	-0.7	0.4	-0.5	-2.8	0.0	-1.1	-0.9	-0.2	0.7	0.9	-0.6	-1.3	-0.8	-1.1	0.1	-0.2	-0.9
Blood White Count	0.1	0.4	2.9	0.2	0.5	-0.3	-1.7	-0.0	-0.5	-1.2	-0.5	-0.3	-0.3	-0.5	-0.6	-0.4	-0.5	0.2	0.7	-0.7
Heel T-Score	0.0	0.4	2.1	-0.5	-1.4	0.0	-1.4	0.1	0.1	0.3	-0.1	0.6	0.5	0.3	-0.4	0.1	-0.1	-0.5	-0.6	0.4
BMI	0.4	2.1	5.1	1.7	2.0	1.4	-2.3	2.1	0.7	-0.6	0.9	-1.9	-1.2	1.3	0.8	1.3	0.8	1.7	1.8	0.2
Height	0.2	3.7	9.6	-2.6	-0.9	-1.5	3.0	-3.1	-0.4	2.0	-0.4	2.9	1.3	-1.7	-0.4	-1.4	-0.4	-2.7	-2.8	0.5
Waist Hip Ratio (WHR)	0.3	1.3	8.4	-0.8	-2.9	0.0	-0.9	-1.6	0.7	1.6	1.0	0.8	-1.2	-0.1	1.1	0.2	0.7	-0.5	-0.4	1.3
Systolic Blood Pressure	0.1	0.4	1.5	-0.6	-0.9	-0.5	-1.2	-0.7	0.1	0.6	-0.0	0.6	-1.0	-0.1	0.5	-0.2	0.1	-0.5	-0.3	0.4
Smoking Status	1.8	4.3	12.0	3.5	2.1	2.2	-1.4	2.4	2.1	0.1	1.3	-2.6	-2.1	2.0	2.0	2.2	2.0	1.9	2.3	1.3
Allergy or Eczema	0.9	2.3	5.2	-1.5	-1.1	-1.7	1.1	-0.8	-1.9	-2.3	-1.9	0.3	0.3	-1.8	-1.7	-1.8	-2.0	-0.2	0.3	-2.3
Cardiovascular Disease	0.1	0.3	2.5	0.1	-0.1	0.2	-1.6	0.2	-0.0	-0.2	0.5	-0.5	-0.7	0.2	0.4	0.3	0.1	0.8	0.7	-0.1
Hypothyroidism (self reported)	0.5	1.1	3.1	-1.5	0.3	-0.7	0.2	-1.7	0.0	1.2	-0.6	1.5	1.0	-0.8	-0.2	-0.7	-0.1	-1.8	-1.7	0.4
Respiratory disease	0.3	0.6	1.9	-0.5	-0.2	-0.7	-0.0	-0.7	-1.3	-1.4	-0.0	-0.3	-0.2	-0.5	-0.7	-0.6	-1.0	0.9	0.7	-1.3
Type 2 Diabetes (T2D) (2018)	1.2	2.3	4.6	-1.8	-0.8	-2.0	0.7	-2.1	-1.6	-0.8	-1.5	1.4	0.7	-2.1	-1.3	-1.9	-1.6	-1.4	-1.0	-1.4
Lung FEV1/FVC ratio	2.9	14.5	37.6	-2.0	1.6	-4.2	1.6	-0.7	-5.4	-5.9	-4.8	0.4	2.9	-3.7	-5.0	-4.2	-5.4	-0.3	-0.1	-6.1
Lung FVC	0.1	0.6	2.6	1.0	1.6	0.8	0.5	0.8	0.9	0.4	0.4	-0.5	-0.5	0.9	0.6	0.7	0.8	0.3	0.4	0.7
Neuroticism	0.6	1.5	11.1	-1.3	-3.3	-1.0	0.2	-1.3	-0.7	0.3	-0.8	1.3	1.0	-0.8	-0.7	-1.1	-0.7	-1.3	-1.4	-0.4
Chronotype (morning person)	0.6	1.4	5.9	-0.6	-0.9	-0.7	-0.5	0.4	-1.7	-2.4	-0.6	-0.8	-0.0	-0.7	-1.2	-0.7	-1.4	1.2	1.2	-1.9
Hair Pigment	0.0	0.8	2.9	0.2	0.4	-0.8	0.6	0.1	-1.2	-1.7	-0.9	-0.3	-0.0	-1.2	-0.8	-0.9	-1.1	0.4	0.7	-1.5
Tanning	0.1	0.7	4.9	-0.9	-2.2	-0.2	1.0	-1.0	0.0	0.8	-0.2	1.0	0.4	-0.0	-0.4	-0.4	-0.2	-1.1	-1.1	0.4
Hand grip strength (left)	0.3	0.7	1.8	-1.3	-0.5	-0.7	1.3	-0.7	-0.3	0.3	-0.4	1.4	0.5	-0.8	-0.6	-0.8	-0.4	-1.2	-1.0	0.1
Number of treatments/medications taken	0.5	0.8	3.7	0.5	-1.0	0.6	-0.1	0.2	0.6	0.2	0.7	-1.0	-1.9	0.7	1.4	0.8	0.8	1.0	1.2	0.5
Average weekly spirits intake	0.7	0.9	3.2	-0.2	0.7	-1.1	0.5	0.0	-0.6	-0.9	-1.8	0.7	0.8	-1.2	-1.2	-1.1	-0.9	-1.2	-0.6	-0.8
Sensitivity / hurt feelings	1.7	2.9	12.0	-2.0	-3.5	-1.5	1.5	-2.6	-1.1	0.6	-0.7	2.0	1.4	-1.6	-0.9	-1.5	-1.0	-1.8	-1.9	-0.5
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.0	1.4	-0.8	1.4	-1.1	0.4	2.0	1.7	1.2	-0.6	-1.5	1.1	1.9	1.4	1.9	0.2	0.5	1.8
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-0.6	0.0	-0.8	-0.2	-0.6	-0.2	-0.0	-1.0	0.6	-0.2	-0.8	-0.4	-0.8	-0.4	-1.1	-0.5	-0.2
Relative age of first facial hair	1.1	2.3	5.3	1.7	-0.4	1.8	-0.0	1.0	2.3	2.2	1.4	-0.6	-0.5	1.6	1.9	1.7	2.2	0.0	-0.1	2.2
Other serious medical condition/disability diagnosed by doctor	4.1	5.3	12.2	2.3	-1.4	2.4	-2.3	2.6	1.3	-0.4	2.5	-3.0	-2.6	2.3	2.1	2.4	1.6	3.5	3.2	0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.2	1.3	0.0	-1.1	0.2	0.7	-0.2	0.3	0.2	0.4	-0.1	-0.3	0.2	0.3	0.2	0.3	0.2	0.2	0.3
Ever had hysterectomy (womb removed)	2.1	2.4	4.5	-0.7	1.3	-1.6	1.1	-0.6	-1.5	-1.1	-1.9	1.6	2.1	-1.8	-2.1	-1.8	-1.7	-1.6	-1.4	-1.4
Systolic blood pressure, automated reading	0.3	0.8	2.2	-0.9	-1.0	-0.9	-0.5	-1.5	-0.0	0.9	-0.6	1.4	-0.7	-0.9	0.2	-0.8	-0.1	-1.4	-0.9	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.2	-0.1	0.2	0.5	0.6	-0.1	-0.6	0.0	-0.3	-0.0	0.0	-0.3	0.1	-0.0	0.4	0.5	-0.2
Angina	0.1	0.1	0.4	-0.7	0.3	-0.2	-0.1	-0.6	-0.4	0.3	0.6	0.2	0.6	0.0	0.1	-0.1	-0.2	0.3	-0.4	-0.3
Medication for hormone replacement therapy	0.8	0.9	3.0	1.7	0.9	0.9	0.9	1.2	1.2	0.6	0.3	-0.7	-0.6	1.1	0.8	1.0	1.0	-0.0	0.3	1.1
Vitamin and mineral supplements	0.9	1.2	3.8	0.8	1.5	0.5	-1.4	1.1	-0.1	-1.0	0.6	-1.5	-1.2	0.8	0.5	0.7	0.0	1.9	1.8	-0.5
Supplements: Zinc	0.2	0.2	1.3	0.2	1.1	0.4	-0.7	0.1	0.2	0.4	0.5	-0.4	0.5	0.5	0.3	0.4	0.3	0.3	-0.2	0.1
Medication: Co-codamol	0.1	0.1	0.5	0.5	0.2	0.2	0.7	0.4	0.6	0.2	-0.3	0.1	0.2	-0.1	0.0	0.1	0.4	-0.5	-0.2	0.4
Medication: Metformin	0.0	0.0	0.2	0.1	0.1	-0.2	-0.2	0.1	-0.2	-0.2	-0.1	0.1	0.3	-0.2	-0.4	-0.2	-0.3	-0.2	-0.2	-0.2
Diabetes (father)	2.0	2.5	4.5	-1.5	0.4	-2.1	1.6	-1.2	-1.8	-1.8	-2.1	0.9	0.8	-1.9	-1.8	-2.0	-1.9	-1.0	-0.5	-1.9
Diabetes (mother)	1.1	1.4	2.6	-1.0	-1.1	-1.5	1.0	-1.4	-0.8	-0.0	-1.4	1.5	0.5	-1.3	-0.9	-1.5	-1.0	-1.6	-1.2	-0.6
Severe depression (siblings)	0.5	0.5	7.0	0.2	2.7	-0.0	0.3	0.4	-0.3	-0.6	0.1	-0.3	0.5	-0.1	-0.4	-0.0	-0.2	0.3	0.2	-0.4
Pack years adult smoking proportion	0.8	1.2	3.5	1.2	0.2	1.1	-1.5	1.3	0.2	-0.8	1.1	-1.6	-0.8	1.0	0.5	1.1	0.4	1.9	1.6	-0.0
Impedance of leg (right)	0.8	3.8	6.1	-2.0	-1.2	-2.5	1.3	-1.8	-2.4	-1.9	-2.3	1.5	1.3	-2.4	-2.3	-2.5	-2.4	-1.2	-0.9	-2.3
Leg fat-free mass (left)	0.8	4.2	6.6	2.2	1.8	2.6	-0.5	2.0	2.6	2.0	2.3	-1.3	-1.4	2.4	2.4	2.5	2.6	1.1	0.9	2.6
Trunk fat percentage	0.1	0.3	2.2	-0.1	0.6	0.0	-1.5	-0.4	0.2	0.6	0.5	0.2	-0.5	0.0	0.6	0.1	0.3	-0.0	-0.1	0.4
Hand grip strength (right)	0.2	0.5	1.6	-1.1	-0.7	-0.4	1.0	-0.9	-0.0	0.7	0.1	1.3	-0.0	-0.6	-0.1	-0.5	-0.0	-0.9	-0.8	0.4
Townsend deprivation index at recruitment	2.8	3.9	6.2	2.4	-0.3	2.4	-1.5	2.5	2.0	0.4	2.1	-2.2	-2.0	2.1	1.9	2.3	2.0	2.2	2.3	1.5
Current tobacco smoking	0.5	0.9	3.1	1.6	1.8	0.8	-1.0	1.8	0.7	-0.5	-0.2	-1.2	-0.1	0.7	0.3	0.7	0.5	0.7	0.9	-0.0
Average weekly fortified wine intake	0.2	0.2	1.9	-0.1	-1.4	-0.1	0.7	-0.7	0.0	0.2	0.1	0.2	-0.3	-0.2	0.3	-0.1	0.2	-0.2	-0.0	0.2
Maternal smoking around birth	0.7	1.0	4.1	1.2	0.6	0.1	-0.3	0.9	0.2	-1.3	-0.9	-1.7	-2.0	0.4	0.5	0.1	0.1	0.9	1.8	-0.7
Fed-up feelings	0.2	0.3	2.8	0.6	-1.7	-0.2	0.4	0.2	0.0	-0.7	-0.6	-0.6	-0.5	-0.2	0.0	-0.2	-0.0	0.2	0.7	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.5	0.9	0.3	1.1	-1.1	0.6	1.2	0.9	1.0	-0.8	-0.9	1.2	1.2	1.1	1.2	0.6	0.6	1.1
Relative age voice broke	0.2	0.3	1.7	0.1	-1.3	0.6	-0.2	0.1	0.6	0.8	0.8	-0.0	0.2	0.6	0.6	0.6	0.7	0.2	-0.2	0.6
Taking other prescription medications	0.3	0.5	2.5	0.2	-1.0	0.4	-0.3	-0.1	0.2	-0.1	0.8	-0.8	-1.6	0.4	0.9	0.5	0.3	1.1	1.2	0.1
Age when periods started (menarche)	0.4	1.1	2.9	1.5	1.7	0.9	-0.4	0.5	1.0	0.9	1.1	-0.6	-1.0	0.8	1.4	1.1	1.1	0.7	0.6	1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.1	0.4	1.1	0.5	-1.5	0.2	0.8	1.3	0.2	0.6	0.6	0.5	0.4	0.4	0.6	-0.8	-1.0	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.7	0.6	-1.4	0.1	-0.1	0.6	0.1	-1.2	-0.4	-1.2	-1.6	0.1	0.4	0.2	0.1	1.0	1.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.5	-0.8	-1.6	-0.6	1.4	-0.5	-0.8	-0.3	-0.4	0.4	1.4	-0.3	-1.0	-0.6	-0.8	-0.5	-0.9	-0.7
Qualifications: CSEs or equivalent	0.3	0.4	1.0	0.2	0.8	-0.4	0.4	0.7	-0.5	-0.4	-1.0	0.1	0.9	0.1	-0.8	-0.5	-0.7	-0.3	-0.6	-0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.9	0.9	0.2	0.4	-0.9	0.2	0.2	0.0	0.2	-0.4	-0.5	0.6	0.4	0.2	0.2	0.4	0.3	0.0
High blood pressure	0.4	1.2	7.8	0.8	0.1	0.8	-2.8	0.6	0.5	0.1	1.2	-0.9	-1.4	1.0	1.1	0.9	0.6	1.2	1.1	0.6
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.7	-1.7	-1.3	-1.5	1.4	-0.7	-1.7	-1.9	-1.5	0.4	0.5	-1.4	-1.6	-1.6	-1.8	-0.2	0.0	-1.9
Multivitamins +/- minerals	0.3	0.4	0.9	0.9	-0.0	0.7	1.0	0.6	0.9	0.6	0.2	-0.3	-0.2	0.5	0.6	0.6	0.8	-0.3	-0.0	0.8
Stomach or abdominal pain in last month	0.1	0.1	0.5	0.7	0.2	0.0	-0.3	0.7	0.1	-0.2	-0.1	-0.2	0.0	-0.0	-0.2	0.0	-0.1	0.0	0.1	-0.0
Supplements: Glucosamine	1.2	1.5	5.0	-1.6	-0.5	-1.2	2.2	-1.2	-1.1	-0.3	-1.1	1.2	1.4	-1.3	-1.2	-1.2	-1.1	-1.2	-1.2	-0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.5	-0.4	-0.5	0.1	-0.5	-0.0	-0.3	-0.9	0.3	-0.7	-1.0	-0.0	0.2	0.0	-0.1	1.1	1.2	-0.5
Medication: Atenolol	0.2	0.3	0.6	0.7	0.4	0.4	-0.6	0.3	0.7	0.8	0.0	-0.1	-0.5	0.5	0.7	0.3	0.6	-0.4	-0.2	0.6
Medication: Levothyroxine sodium	0.3	0.5	1.7	-0.3	-0.1	0.4	-0.4	-0.6	1.0	1.3	0.7	0.2	-0.5	0.2	0.9	0.5	1.0	-0.4	-0.2	1.1
Sitting height	0.1	0.4	2.8	0.1	1.6	-0.2	1.7	0.1	-0.1	-0.1	-0.5	0.3	0.3	-0.4	-0.3	-0.4	-0.2	-0.5	-0.3	-0.2
Chronic bronchitis/emphysema (father)	1.2	1.4	3.7	0.2	-0.1	1.1	-1.1	-0.6	1.4	1.9	1.9	-0.2	-1.4	0.8	1.7	1.1	1.6	0.4	0.3	1.7
High blood pressure (mother)	0.8	1.2	3.7	1.2	1.9	0.7	-1.4	1.9	0.4	-0.8	-0.1	-1.5	-1.2	0.9	0.4	0.7	0.3	1.1	1.4	-0.1
Body mass index (BMI)	1.0	4.1	5.7	2.2	1.9	2.3	-2.1	2.2	2.1	1.1	2.1	-1.8	-1.7	2.3	2.2	2.4	2.2	1.7	1.5	1.9
Impedance of leg (left)	0.9	4.2	7.1	-2.2	-1.3	-2.6	1.0	-2.0	-2.7	-2.0	-2.2	1.5	1.4	-2.5	-2.4	-2.6	-2.6	-1.1	-0.9	-2.5
Leg predicted mass (left)	0.8	4.1	6.4	2.2	1.8	2.5	-0.5	1.9	2.5	1.9	2.2	-1.3	-1.4	2.4	2.4	2.5	2.5	1.1	0.9	2.5
Trunk fat mass	0.1	0.6	1.4	0.5	1.1	0.6	-1.2	0.1	0.8	1.0	0.9	-0.1	-0.7	0.5	1.0	0.7	0.9	0.2	0.1	0.9
Waist circumference	0.5	1.9	3.6	1.2	1.0	1.4	-1.9	1.0	1.2	0.8	1.8	-1.1	-1.6	1.3	1.6	1.6	1.4	1.3	1.2	1.3
Number of incorrect matches in round	1.5	2.5	5.6	1.3	0.5	1.7	-2.4	1.1	1.3	0.3	1.6	-1.8	-2.0	1.7	1.6	1.7	1.5	1.9	1.9	1.0
Past tobacco smoking	0.2	0.4	1.1	-0.8	-0.6	0.4	-1.1	-0.5	0.0	0.4	1.0	-0.2	-0.7	0.5	0.7	0.4	0.3	0.8	0.4	0.2
Alcohol usually taken with meals	0.3	0.5	2.6	-0.7	-1.6	-0.4	1.2	-1.4	-0.3	0.6	0.4	0.9	0.1	-0.4	0.1	-0.3	-0.1	-0.3	-0.5	0.2
Nervous feelings	0.8	1.6	5.3	-1.4	-0.0	-0.8	-0.6	-1.5	0.2	1.7	-0.6	2.0	1.5	-0.9	-0.2	-0.8	0.0	-2.2	-2.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	1.1	0.0	0.9	-1.4	0.9	1.0	0.2	0.4	-0.8	-0.5	0.8	0.7	0.8	0.8	0.6	0.7	0.6
Hearing difficulty/problems with background noise	0.3	0.4	2.8	-0.6	-1.7	-0.3	0.0	-1.0	0.2	0.7	-0.1	0.4	-1.0	-0.3	0.5	-0.3	0.1	-0.6	-0.2	0.3
Hair/balding pattern: Pattern 2	1.3	1.6	4.3	0.1	-2.0	1.3	-0.8	0.2	0.6	0.2	2.1	-1.1	-1.4	1.2	1.4	1.3	1.1	2.0	1.5	0.7
Had menopause	0.2	0.2	1.0	0.3	-0.5	0.6	1.0	0.6	0.6	0.2	0.5	-0.1	0.0	0.4	0.2	0.6	0.6	0.2	0.2	0.6
Had other major operations	0.3	0.3	2.8	-0.5	-1.7	0.1	0.4	-0.2	-0.3	-0.2	0.4	-0.5	-0.6	0.4	0.3	0.1	-0.2	0.8	0.5	-0.3
Forced vital capacity (FVC)	0.1	0.4	5.4	0.3	0.6	-0.0	2.3	-0.3	0.2	0.0	-0.3	0.2	-0.2	0.0	0.0	-0.2	0.1	-0.3	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.8	0.8	-1.1	0.4	-0.4	0.4	0.2	-1.0	0.2	-1.3	-1.9	0.1	0.7	0.4	0.3	1.4	1.9	-0.2
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.9	-2.0	-1.1	-1.4	2.1	-2.2	-0.8	0.6	-0.6	1.6	0.7	-1.6	-0.4	-1.2	-0.8	-1.5	-1.5	-0.3
Qualifications: None of the above	0.1	0.3	1.2	-0.9	-1.1	-0.2	-0.2	-0.7	-0.0	0.6	0.5	0.6	0.8	-0.2	-0.1	-0.1	-0.0	-0.4	-0.7	0.2
Financial difficulties in last 2 years	3.2	4.3	8.6	2.1	-0.4	2.1	-2.6	1.3	2.2	0.9	2.0	-2.1	-2.9	2.3	2.5	2.2	2.2	2.0	2.2	1.7
Mouth/teeth dental problems	1.2	1.8	4.2	-0.8	0.4	-1.5	1.3	-0.4	-1.5	-1.1	-2.0	0.8	1.4	-1.2	-1.7	-1.7	-1.7	-1.2	-1.1	-1.7
Heart attack	0.3	0.3	2.7	-0.2	1.7	-0.3	-0.1	-0.4	-0.0	0.3	-0.3	0.6	0.7	-0.7	-0.1	-0.4	0.0	-0.6	-0.6	-0.1
Allergy	0.5	1.1	4.0	1.4	2.0	0.9	-1.2	0.8	1.4	1.3	0.5	-0.1	0.1	0.8	0.9	0.9	1.2	-0.4	-0.4	1.4
Pain all over the body in last month	0.7	0.7	2.8	-0.7	0.6	-0.6	-0.5	-1.1	0.2	0.9	-0.9	1.3	0.6	-0.8	-0.2	-0.6	-0.1	-1.7	-1.4	0.4
Diabetes (self-reported)	0.3	0.4	1.7	-0.1	0.2	-0.6	1.3	-0.7	0.1	0.2	-0.7	0.7	0.4	-0.8	-0.3	-0.6	-0.1	-1.2	-0.7	-0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.7	-0.2	1.3	-0.3	1.3	0.8	-0.4	-0.9	-1.0	-0.2	0.1	-0.2	-0.7	-0.4	-0.6	-0.2	0.1	-0.6
Medication: Ramipril	0.7	0.9	3.3	-0.0	-0.1	0.8	-1.1	-0.9	1.0	1.8	1.5	0.4	0.1	0.4	1.1	0.8	1.2	-0.2	-0.5	1.3
Medication: Simvastatin	0.5	0.7	2.9	-1.2	-1.7	-0.9	0.7	-1.1	-0.7	0.1	-0.5	0.9	0.7	-0.7	-0.6	-0.8	-0.7	-0.9	-1.0	-0.4
Fluid intelligence score	0.4	0.9	5.6	1.0	-0.4	1.0	-2.4	1.4	0.6	-0.3	0.5	-0.9	-0.6	0.9	0.4	0.9	0.6	0.8	0.9	0.5
Illnesses of siblings	0.3	0.4	1.3	1.1	0.7	0.6	-1.1	0.9	0.6	-0.0	0.2	-0.7	-0.5	0.9	0.3	0.6	0.5	0.5	0.5	0.3
Neuroticism score	0.5	1.0	6.2	-0.8	-2.5	-0.9	-0.3	-1.3	-0.6	0.1	-0.7	1.2	0.8	-0.9	-0.8	-0.9	-0.7	-1.0	-1.0	-0.4
Weight	0.5	2.5	3.6	1.6	1.7	1.9	-1.0	1.5	1.8	1.4	1.8	-1.1	-1.2	1.8	1.9	1.9	1.9	1.1	0.8	1.8
Impedance of arm (right)	2.2	10.3	25.0	-4.6	-3.3	-4.1	1.2	-5.0	-3.4	-0.6	-2.6	3.4	1.6	-3.8	-2.4	-3.9	-3.2	-2.8	-2.7	-2.5
Arm fat percentage (right)	0.2	0.6	3.2	0.1	0.8	0.5	-1.8	-0.1	0.7	1.0	0.8	-0.3	-1.0	0.6	1.1	0.6	0.8	0.2	0.2	0.8
Trunk fat-free mass	0.9	5.0	8.5	2.7	2.0	2.9	0.4	2.6	2.8	1.6	2.4	-1.7	-1.4	2.6	2.3	2.8	2.7	1.5	1.4	2.6
Hip circumference	0.4	1.7	3.9	1.4	2.0	1.5	-1.4	1.5	1.1	0.4	1.4	-1.3	-1.0	1.4	1.3	1.5	1.2	1.3	1.1	1.0
Time employed in main current job	0.6	0.7	1.3	1.2	0.5	1.0	0.0	1.1	0.9	0.5	0.9	-0.9	-0.6	1.1	0.9	1.1	0.8	0.9	0.6	0.7
Alcohol intake versus 10 years previously	0.3	0.4	4.8	-0.1	-2.2	-0.1	0.7	-0.8	0.1	0.6	0.3	0.3	-0.4	-0.4	0.4	-0.3	0.2	-0.3	-0.2	0.2
Father’s age at death	1.2	1.6	2.8	1.4	-1.5	1.4	-0.2	0.6	1.1	0.6	1.6	-1.2	-1.7	1.5	1.4	1.4	1.2	1.4	1.3	1.1
Worrier / anxious feelings	1.1	2.1	3.1	-1.7	-1.1	-1.7	-0.4	-1.4	-1.5	-0.4	-1.6	1.7	1.6	-1.1	-1.6	-1.7	-1.6	-1.6	-1.8	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.1	0.6	-0.6	0.6	-1.1	0.7	0.7	0.3	0.4	-0.4	-1.0	0.5	0.6	0.5	0.6	0.3	0.6	0.6
Falls in the last year	0.1	0.1	0.4	0.1	-0.4	0.1	-0.3	-0.6	0.3	0.7	0.4	0.3	-0.0	-0.2	0.4	0.2	0.4	-0.3	-0.3	0.6
Hair/balding pattern: Pattern 3	0.7	1.1	3.7	-0.1	1.5	-0.8	0.2	0.2	-0.7	-0.1	-1.3	0.9	1.9	-0.5	-1.3	-0.9	-0.9	-1.4	-1.5	-0.6
Number of live births	0.2	0.3	1.9	-0.6	-1.4	0.2	0.6	0.6	-0.1	-0.2	0.6	-0.3	0.1	0.5	0.0	0.4	-0.0	0.7	0.3	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	5.2	-0.2	0.8	-1.0	2.3	-0.4	-1.1	-1.5	-1.5	0.1	0.1	-0.8	-1.0	-1.1	-1.1	-0.2	0.2	-1.4
Pulse rate	2.0	3.3	6.6	2.5	2.0	1.9	0.0	2.4	1.2	-0.5	1.5	-2.6	-1.4	2.1	1.4	2.0	1.3	2.6	2.3	0.6
Happiness	0.6	0.8	2.4	-0.7	-1.2	-0.6	0.1	-1.2	0.4	1.4	-0.3	1.3	0.4	-0.5	0.1	-0.5	0.1	-1.5	-1.4	0.7
Noisy workplace	0.3	0.4	2.1	-1.4	-1.2	-0.5	-0.2	-0.8	-0.4	0.1	0.1	0.9	0.3	-0.6	-0.4	-0.5	-0.4	-0.4	-0.5	-0.0
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.5	-2.0	-1.3	-2.0	1.2	-2.1	-1.5	-0.2	-1.5	1.9	1.0	-1.8	-1.3	-1.9	-1.5	-1.8	-1.7	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	2.4	0.4	-1.5	0.5	-1.4	0.6	0.2	-0.5	0.6	-0.7	-1.2	0.2	0.5	0.5	0.3	1.1	1.3	0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	-1.1	-0.2	-0.9	1.1	-0.1	-1.3	-1.6	-1.0	-0.0	1.0	-0.7	-1.3	-0.8	-1.3	0.3	0.1	-1.5
Asthma	0.1	0.2	0.8	-0.6	-0.9	-0.4	0.0	-0.7	-0.6	-0.3	0.3	0.1	-0.5	-0.1	-0.1	-0.3	-0.5	0.5	0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.7	0.0	-1.6	-0.1	0.5	-0.5	0.4	0.9	-0.0	0.6	-0.1	0.2	0.3	-0.0	0.3	-0.8	-0.7	0.6
Medication: Cholesterol lowering	1.1	1.7	3.1	-1.6	-0.3	-1.8	0.5	-1.3	-1.4	-0.8	-1.7	1.1	1.0	-1.6	-1.3	-1.7	-1.4	-1.3	-1.0	-1.5
Depression (self-reported)	0.3	0.4	4.0	-0.5	-2.0	-0.3	-0.5	-1.0	-0.2	0.0	-0.1	0.1	-0.8	-0.5	0.4	-0.3	-0.1	-0.0	0.2	-0.1
Medication: Lansoprazole	0.9	1.0	2.2	1.3	-0.2	1.1	0.4	0.3	0.6	0.3	1.4	-1.3	-1.2	1.2	1.2	1.2	0.9	1.5	1.2	0.6
Prospective memory result	5.5	6.7	11.8	2.7	0.2	2.9	-1.2	1.9	2.9	1.3	2.7	-2.9	-3.4	2.8	3.4	3.0	2.9	2.6	2.8	2.2
Lung cancer (father)	1.7	2.0	3.9	1.9	-0.4	1.8	-0.8	1.6	1.4	0.4	1.5	-1.5	-1.0	2.0	1.3	1.7	1.5	1.6	1.3	1.1
Illnesses of mother	2.1	2.6	7.7	-2.3	-1.8	-1.1	1.2	-2.8	-0.2	1.9	-0.1	2.4	1.4	-1.2	-0.4	-1.1	-0.2	-2.3	-2.5	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.7	0.2	1.3	-0.5	1.6	-0.2	-0.7	-1.2	-1.2	-0.1	-0.1	-0.4	-0.7	-0.7	-0.8	-0.1	0.3	-1.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	-0.4	0.7	-0.3	0.7	0.0	-0.7	-0.9	-0.1	0.0	0.4	-0.5	-0.7	-0.3	-0.7	0.4	0.3	-0.6
Impedance of arm (left)	2.0	9.1	20.1	-4.1	-2.4	-3.9	0.9	-4.5	-3.5	-1.1	-2.5	3.0	1.7	-3.7	-2.6	-3.8	-3.2	-2.5	-2.4	-2.8
Arm fat mass (right)	0.6	2.3	3.9	1.3	1.1	1.7	-1.7	1.0	1.7	1.5	1.8	-1.0	-1.5	1.6	2.0	1.7	1.8	1.0	0.8	1.8
Trunk predicted mass	0.9	5.3	8.9	2.8	2.1	3.0	0.3	2.7	2.9	1.6	2.4	-1.7	-1.4	2.6	2.4	2.9	2.8	1.5	1.4	2.7
Standing height	0.2	1.5	7.6	-1.3	-0.5	-0.9	2.8	-1.5	-0.6	0.6	-0.5	1.7	1.1	-1.2	-0.7	-1.0	-0.6	-1.5	-1.5	-0.1
Length of working week for main job	1.7	1.9	3.9	-1.1	-1.1	-1.6	-1.3	-1.2	-1.8	-1.7	-1.7	0.5	0.6	-1.6	-1.4	-1.7	-1.7	-0.5	-0.2	-2.0
Exposure to tobacco smoke at home	1.8	2.0	3.6	1.9	0.4	1.6	-1.2	1.4	1.5	1.0	1.6	-1.2	-1.2	1.4	1.7	1.7	1.7	1.2	1.1	1.4
Breastfed as a baby	0.3	0.4	1.7	0.2	0.3	-0.3	0.7	0.4	-0.9	-0.9	-0.1	0.1	1.3	-0.5	-1.0	-0.3	-0.7	0.2	-0.1	-0.8
Tense / ‘highly strung’	0.6	0.9	1.9	-1.4	-0.9	-1.0	-0.8	-1.2	-0.9	-0.1	-0.7	1.1	1.0	-1.0	-0.9	-1.1	-0.8	-1.1	-1.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.2	-1.3	-1.8	-0.7	-0.1	-1.3	-0.9	-0.2	-0.2	0.6	-0.0	-0.6	-0.4	-0.7	-0.8	-0.2	-0.3	-0.5
Hair/balding pattern: Pattern 4	1.4	3.4	5.2	1.6	1.8	2.0	-1.2	1.1	1.9	1.2	2.2	-1.7	-2.2	2.0	2.3	2.1	2.0	1.8	1.6	1.8
Birth weight of first child	2.0	3.6	8.3	-1.9	0.3	-2.2	0.5	-1.5	-2.9	-2.2	-1.8	1.0	1.8	-1.9	-2.4	-2.1	-2.7	-0.5	-0.7	-2.7
Peak expiratory flow (PEF)	0.2	0.4	3.3	-0.2	-1.8	-0.3	1.3	-0.3	-0.4	-0.6	-0.4	0.1	-0.1	-0.3	-0.3	-0.4	-0.3	0.1	0.2	-0.5
Pulse wave reflection index	0.7	0.8	2.0	-1.1	-0.8	-0.8	0.8	-0.9	-0.4	0.2	-0.7	1.4	1.1	-1.1	-1.0	-0.9	-0.6	-1.4	-1.2	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	0.8	0.6	0.3	-0.5	0.6	0.3	-0.4	-0.0	-0.9	-1.1	0.8	0.5	0.4	0.2	0.6	0.9	0.0
Loud music exposure frequency	1.8	2.0	5.3	-1.5	-2.3	-0.8	0.5	-2.0	0.2	1.9	-0.4	2.0	0.9	-0.8	0.0	-0.8	0.0	-2.2	-2.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	6.5	-1.2	-2.5	-0.4	-0.9	-1.3	-0.2	0.6	-0.2	1.2	-0.5	-0.3	-0.0	-0.6	-0.2	-0.8	-0.7	0.3
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	6.2	0.8	-1.7	1.8	-1.2	-0.1	2.1	2.5	2.3	-0.5	-1.4	1.8	2.4	1.8	2.3	0.5	0.2	2.4
Blood clot in the leg (DVT)	0.7	0.8	2.4	0.3	-1.1	1.0	0.7	-0.0	0.6	0.6	1.6	-0.9	-0.8	1.1	1.1	1.1	0.8	1.3	0.8	0.6
Medication: Paracetamol	0.1	0.2	0.7	-0.3	0.1	0.1	0.1	-0.3	0.4	0.8	0.4	0.5	-0.1	0.0	0.3	0.2	0.4	-0.5	-0.4	0.7
Headache pain in last month	2.2	3.7	7.4	-1.7	0.0	-2.3	2.6	-1.4	-2.0	-1.4	-2.7	1.4	1.7	-2.0	-2.2	-2.3	-2.2	-1.8	-1.5	-2.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.2	1.6	-0.2	1.8	0.3	1.2	2.0	1.7	1.7	-0.7	-0.8	1.6	1.6	1.8	1.8	0.6	0.4	2.0
Glaucoma (self-reported)	0.5	0.6	1.6	0.5	-0.9	0.6	-0.0	0.4	0.9	0.4	0.9	-0.4	-1.3	0.5	0.9	0.7	0.9	0.6	0.9	0.9
Gout (self-reported)	0.3	0.4	1.3	-0.3	-0.6	-0.5	1.0	0.3	-0.8	-1.1	-0.8	-0.5	0.0	-0.2	-0.4	-0.5	-0.7	0.3	0.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.3	-0.7	0.8	0.1	-0.9	-0.9	0.8	1.5	0.2	0.8	0.2	-0.1	0.5	0.1	0.8	-1.2	-1.0	1.0
Medication: Amlodipine	0.3	0.5	2.4	0.2	0.6	-0.0	-1.5	1.1	-0.4	-1.2	-0.4	-0.9	-0.3	0.2	-0.2	0.1	-0.3	0.8	0.9	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.0	-0.2	-0.5	-0.5	0.8	-0.2	-0.7	-1.0	-0.2	-0.3	-0.4	-0.1	-0.4	-0.4	-0.6	0.6	0.6	-0.8
Birth weight	0.6	1.2	4.8	-0.4	-1.2	-0.6	1.2	0.3	-1.7	-2.2	-0.5	-0.6	0.2	-0.2	-1.1	-0.5	-1.4	1.2	0.9	-1.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	0.7	0.2	0.4	0.2	0.8	0.3	-0.2	-0.1	-0.7	-0.8	0.7	0.4	0.3	0.3	0.5	0.7	-0.0
High blood pressure (siblings)	0.3	0.5	1.8	0.3	0.0	0.4	-0.7	0.6	0.1	-0.6	0.2	-0.9	-1.3	0.2	0.7	0.4	0.2	1.1	1.4	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	2.7	0.5	0.9	0.3	1.6	-0.1	0.4	0.3	0.0	0.0	-0.3	0.4	0.2	0.1	0.3	-0.1	-0.1	0.3
Body fat percentage	0.1	0.5	2.8	0.4	1.1	0.4	-1.7	0.1	0.6	0.7	0.6	-0.1	-0.6	0.5	0.8	0.5	0.7	0.1	0.1	0.7
Leg fat percentage (right)	0.5	1.9	4.9	1.7	2.2	1.4	-1.8	1.7	1.3	0.4	1.0	-1.2	-0.9	1.4	1.2	1.4	1.4	1.0	1.1	1.0
Arm fat-free mass (right)	1.3	6.9	11.8	3.2	2.4	3.4	-0.4	3.3	3.0	1.6	2.9	-2.1	-1.5	3.1	2.5	3.3	3.0	2.0	1.7	2.8
Exposure to tobacco smoke outside home	0.5	0.7	1.6	0.7	-0.3	0.9	-0.6	0.6	0.6	0.2	1.2	-0.9	-0.8	0.7	1.0	1.0	0.8	1.2	1.0	0.6
Comparative body size at age 10	0.6	1.5	7.9	-0.1	-2.8	0.8	-0.6	-0.7	1.2	1.9	1.2	-0.1	-1.4	1.1	1.6	0.9	1.2	-0.0	-0.1	1.5
Number of full brothers	1.0	1.2	3.6	0.8	-0.0	1.0	-0.9	1.9	0.5	-0.8	0.5	-1.9	-1.2	0.9	0.8	1.0	0.5	1.7	1.8	-0.1
Worry too long after embarrassment	1.1	1.9	3.3	-1.8	-1.7	-1.4	-0.6	-1.5	-1.2	0.0	-1.2	1.8	1.6	-1.3	-1.3	-1.6	-1.2	-1.5	-1.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	3.6	-0.2	-1.9	0.3	-0.4	-0.4	0.6	0.7	0.1	-0.5	-1.0	0.8	0.8	0.4	0.4	-0.0	0.1	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.5	0.5	-0.3	0.7	-0.9	0.1	0.3	0.0	1.2	-0.7	-1.1	0.8	0.7	0.7	0.4	1.2	1.0	0.4
Number of children fathered	1.1	1.2	5.3	0.8	1.5	-0.3	-0.3	1.0	-1.2	-2.3	-0.8	-1.1	-0.2	-0.0	-0.9	-0.4	-1.1	1.3	1.4	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.6	-0.6	-1.9	-1.0	0.2	-0.7	-1.5	-1.4	-0.8	0.5	0.5	-1.4	-1.1	-1.1	-1.3	-0.0	0.1	-1.3
Age at first live birth	2.6	4.7	7.6	-2.5	-0.9	-2.6	1.1	-2.1	-2.3	-1.1	-2.6	2.1	1.9	-2.5	-2.4	-2.8	-2.4	-2.2	-2.0	-2.1
Pulse wave peak to peak time	0.2	0.2	0.8	0.4	-0.6	0.2	-0.5	-0.1	0.6	0.9	0.2	0.1	-0.2	0.4	0.6	0.3	0.6	-0.4	-0.3	0.6
Health satisfaction	0.6	0.7	2.7	-0.6	-1.1	0.2	1.4	-0.6	0.6	1.6	0.5	0.8	0.8	0.4	0.5	0.3	0.5	-0.8	-1.3	1.0
Shortness of breath walking on level ground	0.7	0.8	2.3	0.1	0.1	0.9	1.4	0.3	1.2	1.5	1.2	-0.1	-0.1	0.8	1.1	1.0	1.2	0.0	-0.2	1.3
Qualifications: College or University degree	0.2	0.7	1.6	-0.3	-0.8	-1.0	1.2	-1.0	-0.7	-0.4	-1.3	0.6	-0.2	-1.0	-0.5	-1.1	-0.8	-0.9	-0.5	-0.6
Eye problems/disorders: None of the above	0.6	0.7	2.7	-0.5	-0.0	-0.3	0.1	-1.4	0.3	1.7	0.0	1.2	0.3	-0.5	0.4	-0.4	0.2	-1.5	-1.5	0.8
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.9	0.7	0.6	1.0	-1.4	0.4	0.8	0.6	1.4	-1.0	-1.1	1.0	1.2	1.1	0.9	1.1	0.9	0.8
Emphysema/chronic bronchitis	0.5	0.6	1.8	1.0	1.0	0.4	0.9	1.1	-0.2	-1.0	0.3	-1.2	-0.2	0.3	0.1	0.5	-0.0	1.3	1.2	-0.5
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	-0.8	-0.4	-0.7	0.7	0.0	-1.0	-1.1	-1.0	0.4	1.0	-1.0	-1.2	-0.9	-1.1	-0.3	-0.3	-1.1
Neck or shoulder pain in last month	0.7	1.0	2.1	1.2	0.4	1.3	-0.2	1.4	1.1	0.2	0.8	-1.1	-0.7	1.4	0.8	1.2	1.1	1.0	0.9	0.7
Medication: Blood pressure	0.7	1.2	3.4	-1.1	-0.5	-1.0	-0.7	-0.5	-1.9	-1.7	-0.6	0.1	0.7	-0.9	-1.4	-1.1	-1.6	0.4	0.1	-1.8
Angina (self-reported)	0.1	0.1	0.4	-0.7	0.3	-0.2	-0.1	-0.6	-0.5	0.3	0.6	0.3	0.6	0.0	0.1	-0.1	-0.2	0.4	-0.4	-0.3
Migraine (self-reported)	0.9	1.1	2.7	-1.1	-0.6	-1.4	0.2	-0.7	-1.3	-1.1	-1.6	0.6	0.5	-1.0	-1.2	-1.4	-1.4	-0.7	-0.5	-1.4
Medication: Ibuprofen	0.5	0.6	2.3	-0.3	-1.5	-0.6	1.4	-0.9	0.1	0.8	-0.6	0.9	0.4	-0.1	-0.0	-0.5	0.0	-1.3	-1.2	0.3
Medication: Allopurinol	0.1	0.2	0.7	-0.1	-0.5	-0.3	0.1	0.3	-0.5	-0.9	-0.4	-0.4	-0.1	0.0	-0.3	-0.2	-0.4	0.3	0.4	-0.7
Medication: Omeprazole	0.3	0.4	2.6	-0.1	1.6	-0.5	-1.0	-0.1	-0.4	-0.5	-0.6	-0.3	-0.8	-0.5	0.2	-0.4	-0.4	0.1	0.5	-0.6
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.0	0.7	-0.1	0.3	-0.5	-0.3	-0.0	0.5	0.3	-0.2	-0.6	0.0	-0.1	-0.2	0.3	0.2	0.0
Mean time to correctly identify matches	1.7	3.3	6.9	1.5	0.2	2.1	-2.3	0.7	1.8	1.1	2.6	-1.4	-1.7	1.9	2.1	2.2	2.1	2.0	1.7	1.8
Heart disease (mother)	1.0	1.2	4.8	0.7	0.2	0.2	-0.5	1.4	-1.0	-2.2	-0.1	-1.5	-0.4	0.3	-0.5	0.2	-0.8	1.9	1.8	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	4.7	-1.5	-1.5	-1.9	2.2	-2.1	-1.7	-0.6	-1.6	1.7	1.1	-1.7	-1.4	-1.9	-1.6	-1.6	-1.5	-1.3
Whole body fat mass	0.3	1.1	1.8	0.9	1.4	1.1	-1.2	0.6	1.2	1.3	1.2	-0.4	-0.7	1.1	1.3	1.1	1.3	0.4	0.2	1.3
Leg fat mass (right)	0.7	2.7	3.7	1.8	1.9	1.8	-1.7	1.7	1.8	1.1	1.6	-1.3	-1.4	1.8	1.8	1.9	1.9	1.1	1.1	1.7
Arm predicted mass (right)	1.5	7.7	13.2	3.4	2.7	3.6	-0.6	3.5	3.2	1.7	3.0	-2.2	-1.6	3.2	2.7	3.5	3.2	2.1	1.9	3.0
Pulse rate, automated reading	0.6	1.9	4.9	1.7	1.1	1.4	-1.5	1.5	0.6	-0.4	1.6	-1.6	-1.2	1.5	0.9	1.5	0.9	2.2	1.8	0.5
Alcohol intake frequency.	0.3	0.7	6.5	-0.7	-2.5	0.2	-1.3	-0.1	-0.3	0.5	0.9	0.6	0.8	0.2	-0.5	0.0	-0.2	0.1	-0.6	0.2
Comparative height size at age 10	0.0	0.3	1.4	-0.0	-0.7	-0.1	1.2	-0.8	0.3	0.5	0.1	0.2	-0.7	-0.3	0.5	-0.0	0.3	-0.4	-0.1	0.5
Number of full sisters	3.6	4.4	7.0	2.0	1.4	2.2	-2.0	1.6	2.2	1.0	2.2	-2.2	-2.6	2.6	2.5	2.4	2.2	2.0	2.0	1.8
Suffer from ‘nerves’	0.7	1.1	2.8	0.7	-0.9	1.2	-1.4	0.4	1.5	1.6	0.9	-0.0	-0.7	1.1	1.2	1.1	1.3	-0.2	-0.2	1.7
Overall health rating	1.0	2.1	6.8	1.4	-0.0	1.6	-2.6	1.2	1.2	0.9	1.7	-1.3	-1.2	1.9	1.7	1.6	1.3	1.6	1.0	1.0
Chest pain or discomfort	0.2	0.2	2.2	0.6	1.5	0.4	-0.1	0.7	-0.0	-0.0	0.4	-0.1	0.5	0.4	-0.1	0.3	-0.0	0.4	-0.0	-0.0
Had major operations	0.4	0.5	1.6	-0.4	1.1	-0.4	0.5	-0.2	-1.1	-1.3	-0.1	-0.1	0.2	-0.7	-0.6	-0.5	-0.8	0.8	0.6	-1.1
Age at last live birth	2.6	3.7	5.7	-2.3	-0.9	-2.3	0.6	-1.4	-2.4	-1.3	-2.0	1.7	2.3	-2.3	-2.3	-2.2	-2.4	-1.4	-1.6	-2.1
Family relationship satisfaction	0.4	0.5	1.7	-0.1	-1.3	0.1	-0.1	-0.4	0.7	1.3	0.4	0.8	0.5	0.2	0.2	0.2	0.5	-1.0	-1.0	1.0
Leg pain on walking	0.6	0.7	5.3	-1.2	-2.3	-0.6	0.4	-0.8	-0.4	0.2	-0.3	1.0	0.8	-0.7	-0.7	-0.6	-0.5	-0.8	-0.9	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.7	-0.4	-1.6	0.3	-0.9	0.1	0.3	0.2	0.4	-0.3	-0.9	0.3	0.6	0.3	0.4	0.4	0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-0.9	0.0	-0.9	1.0	-0.6	-0.5	-0.2	-1.3	1.1	0.8	-0.8	-1.0	-1.1	-0.7	-1.3	-1.0	-0.5
Illness, injury, bereavement, stress in last 2 years	3.0	3.7	9.0	-2.0	0.6	-1.8	3.0	-2.0	-0.8	0.9	-1.6	2.7	2.2	-2.0	-1.3	-1.7	-1.0	-2.9	-2.8	-0.1
Medication: Aspirin	1.7	2.2	4.0	1.8	1.1	1.6	-1.2	1.7	1.1	-0.0	1.4	-2.0	-1.5	1.8	1.4	1.6	1.3	2.0	1.8	0.5
Supplements: Vitamin C	2.9	3.5	15.0	-2.5	-3.9	-1.4	0.5	-2.8	-1.0	1.2	-0.4	2.6	1.5	-1.4	-0.9	-1.4	-0.9	-2.1	-2.5	0.0
Knee pain experienced in last month	0.1	0.2	0.9	-0.7	-0.9	0.1	-0.5	-0.0	-0.1	0.3	0.2	0.6	0.8	-0.1	-0.4	-0.0	-0.1	-0.3	-0.6	0.2
Hypertension (Self-reported)	0.3	0.7	6.4	0.6	0.3	0.5	-2.5	0.3	0.3	0.1	0.9	-0.5	-1.0	0.6	0.7	0.6	0.4	0.8	0.8	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.9	-2.1	-1.5	-1.3	0.6	-2.2	-1.4	0.1	-0.3	1.2	0.6	-1.1	-0.5	-1.2	-1.1	-0.6	-1.0	-0.9
Illnesses of father: Heart disease	0.5	0.7	7.2	0.2	0.8	0.5	-2.7	0.9	0.1	-0.2	0.3	-0.8	-0.4	0.6	0.3	0.5	0.2	0.8	0.6	-0.0
Illnesses of siblings: Diabetes	1.2	1.5	5.3	-0.7	0.8	-0.8	0.6	-1.1	0.1	1.5	-0.5	1.9	2.0	-1.1	-0.6	-0.8	-0.2	-2.2	-2.3	0.5
Smoking status: Previous	0.1	0.1	1.0	0.8	-0.0	-0.2	1.0	0.0	0.1	-0.2	-0.4	0.1	0.2	-0.4	-0.2	-0.2	-0.0	-0.4	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	1.0	1.0	0.2	0.3	0.8	0.6	0.2	-0.3	-0.2	-0.3	-0.4	0.3	0.1	0.2	0.1	0.2	0.4	0.1
Whole body fat-free mass	0.9	5.3	8.8	2.7	2.2	3.0	-0.0	2.6	2.8	1.8	2.5	-1.7	-1.5	2.7	2.5	2.9	2.8	1.5	1.4	2.7
Leg fat-free mass (right)	0.7	3.6	5.8	1.9	1.6	2.4	-0.5	1.6	2.4	2.0	2.3	-1.2	-1.3	2.2	2.3	2.4	2.4	1.0	0.7	2.4
Arm fat percentage (left)	0.3	1.0	4.0	0.6	1.1	0.9	-2.0	0.3	0.9	1.0	1.1	-0.6	-1.1	1.0	1.3	0.9	1.1	0.6	0.4	1.0
Average weekly red wine intake	0.1	0.2	1.1	0.1	1.0	-0.1	0.4	-0.6	0.4	0.5	0.1	0.5	-0.4	-0.2	0.1	-0.1	0.2	-0.5	-0.2	0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	4.5	0.2	0.3	0.5	-2.1	1.0	-0.0	-0.7	0.4	-0.7	-0.3	0.5	-0.1	0.4	-0.0	0.9	0.8	-0.1
Mood swings	0.8	1.4	2.6	-0.7	-0.3	-1.4	0.4	-1.0	-1.3	-0.8	-1.6	1.0	1.5	-1.4	-1.5	-1.5	-1.3	-1.1	-1.1	-1.3
Loneliness, isolation	1.2	1.7	6.8	1.7	-2.6	1.2	-0.8	1.5	1.0	-0.4	0.4	-1.4	-1.5	1.2	0.9	1.2	0.9	1.3	1.6	0.6
Long-standing illness, disability or infirmity	0.2	0.4	1.1	0.3	-0.2	0.2	-0.9	0.8	-0.0	-0.7	0.1	-0.9	-0.9	0.3	0.3	0.3	-0.0	1.0	1.1	-0.3
Ever had bowel cancer screening	0.4	0.4	1.8	0.5	-0.1	0.3	-1.3	0.1	0.0	-0.4	0.7	-0.5	-1.2	0.0	0.5	0.3	0.2	1.0	1.2	0.1
Diabetes diagnosed by doctor	0.3	0.5	1.9	-0.1	0.1	-0.7	1.0	-0.7	0.0	0.4	-0.8	0.9	0.4	-0.9	-0.2	-0.7	-0.2	-1.4	-0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.4	1.1	1.6	0.1	-0.3	2.1	-0.7	-2.1	-0.5	-1.4	-0.1	0.6	-0.9	0.1	-0.7	1.4	1.4	-1.2
Friendships satisfaction	1.1	1.3	4.7	0.5	-0.8	1.0	-2.2	0.0	1.3	1.5	1.4	-0.3	-1.1	1.3	1.4	1.1	1.3	0.4	0.2	1.4
Qualifications: nursing, teaching	0.7	1.1	7.3	-0.2	-2.7	0.3	-0.1	-1.5	0.6	1.6	1.2	0.7	-0.9	0.2	1.0	0.4	0.8	-0.3	-0.4	1.3
Commuting to job workplace: Walk	0.9	0.9	2.8	-0.8	0.1	-0.3	1.1	-1.1	0.4	1.7	0.3	1.5	1.1	-0.8	0.0	-0.2	0.3	-1.6	-1.6	0.9
Eye problems/disorders: Cataract	0.2	0.3	1.4	-0.5	0.6	-0.3	0.1	-0.0	-0.6	-0.3	-0.1	0.5	1.2	-0.3	-0.7	-0.3	-0.5	0.0	-0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	-0.0	-0.2	-0.1	0.4	-0.1	-0.0	-0.4	0.1	0.1	-0.2	-0.6	0.1	-0.0	0.1	0.4	0.6	-0.1
Medication for cholesterol	4.2	6.3	10.7	-2.9	0.3	-2.7	1.8	-1.5	-3.2	-2.1	-2.7	1.7	3.2	-2.4	-3.3	-2.9	-3.2	-1.4	-1.9	-3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	-1.2	0.0	-0.5	-0.5	-0.9	-0.6	0.4	-0.1	0.8	0.9	-0.1	-0.6	-0.6	-0.6	-0.6	-1.1	-0.3
Back pain experienced in last month	0.4	0.5	1.9	0.4	1.0	0.5	-0.2	0.2	1.0	1.4	0.3	0.5	0.2	0.7	0.6	0.5	0.8	-0.7	-0.8	1.2
Mineral and other dietary supplements	2.5	3.4	13.5	2.3	1.2	1.4	-3.7	2.7	0.8	-1.0	0.6	-2.4	-1.9	1.7	0.9	1.4	0.7	2.1	2.3	0.2
Breast cancer (self-reported)	0.4	0.5	2.0	-0.7	1.4	-0.6	-1.1	-0.2	-1.0	-1.0	-0.7	-0.1	0.1	-0.3	-0.5	-0.5	-0.8	0.3	0.2	-1.0
Asthma (self-reported)	0.1	0.3	0.9	-0.4	-0.9	-0.1	-0.3	-0.5	-0.5	-0.5	0.5	-0.3	-0.8	0.2	0.1	-0.0	-0.4	0.9	0.7	-0.4
Osteoporosis (self-reported)	5.7	7.1	15.4	2.6	-2.7	2.7	-2.3	1.5	2.5	1.0	2.9	-2.4	-3.9	2.6	3.2	2.8	2.7	2.8	3.0	2.3
Osteoarthritis (self-reported)	0.3	0.4	1.5	-0.5	-0.8	0.3	1.2	-0.2	0.1	0.8	1.1	0.4	0.9	0.0	0.2	0.4	0.3	0.1	-0.5	0.6
Medication: Aspirin	2.1	2.7	4.4	2.0	1.3	1.8	-1.4	1.6	1.2	0.2	1.7	-2.0	-1.8	1.9	1.7	1.8	1.5	2.1	1.9	0.8
Medication: Gliclazide	0.5	0.5	1.3	-1.1	-0.9	-0.7	-0.3	-0.6	-0.9	-0.4	-0.2	0.6	1.0	-0.9	-0.9	-0.7	-0.8	-0.3	-0.5	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	1.6	0.3	-1.3	0.6	1.1	-0.2	0.3	0.4	0.9	-0.1	0.1	0.3	0.4	0.5	0.4	0.4	0.1	0.4
Smoking status: Current	0.5	0.8	2.9	1.6	1.7	0.7	-0.6	1.7	0.7	-0.4	-0.3	-1.1	-0.1	0.6	0.3	0.6	0.5	0.5	0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	9.5	-1.4	0.4	-2.4	0.9	-1.1	-2.8	-2.8	-3.1	0.8	0.6	-2.0	-2.6	-2.7	-2.9	-1.0	-0.4	-3.0
Whole body water mass	1.0	5.5	9.0	2.8	2.3	3.0	-0.1	2.7	2.8	1.7	2.5	-1.8	-1.5	2.7	2.5	3.0	2.8	1.6	1.4	2.6
Leg predicted mass (right)	0.7	3.6	5.7	1.9	1.7	2.4	-0.4	1.7	2.4	2.0	2.2	-1.1	-1.2	2.2	2.3	2.3	2.4	1.0	0.7	2.4
Arm fat mass (left)	0.6	2.4	3.6	1.5	1.5	1.7	-1.7	1.2	1.7	1.3	1.7	-1.2	-1.5	1.7	1.9	1.7	1.8	1.1	1.0	1.6
Number of self-reported non-cancer illnesses	0.6	1.1	3.3	0.4	0.6	0.9	-1.4	0.5	0.3	-0.2	1.6	-1.0	-1.6	0.9	1.0	1.0	0.5	1.8	1.6	0.4
Average weekly champagne plus white wine intake	0.7	0.9	2.5	-0.2	1.6	-1.0	1.5	-0.3	-0.6	-0.8	-1.6	0.8	0.3	-1.1	-0.9	-1.1	-0.8	-1.0	-0.4	-0.7
Miserableness	0.5	0.9	3.0	-0.4	-1.7	-1.0	1.6	-1.5	-0.4	0.2	-0.8	1.1	0.4	-0.9	-0.5	-0.8	-0.4	-1.2	-0.9	-0.1
Guilty feelings	0.5	0.8	5.6	-0.1	-2.4	0.5	-0.8	-0.7	0.9	1.1	0.8	0.3	-0.6	0.4	0.8	0.5	0.9	-0.2	-0.1	1.1
Wears glasses or contact lenses	0.2	0.2	1.1	0.4	0.1	0.0	0.7	0.3	-0.2	-0.4	-0.1	0.2	1.1	-0.1	-0.8	0.0	-0.2	-0.1	-0.2	-0.1
Ever taken oral contraceptive pill	0.7	0.8	4.5	0.3	0.8	-0.7	2.1	0.5	-0.5	-1.5	-1.3	-0.5	-0.2	-0.8	-0.6	-0.6	-0.6	0.1	0.7	-1.1
Hearing aid user	0.5	0.6	1.5	-0.9	1.2	-0.8	0.3	-0.2	-1.1	-1.0	-0.8	0.3	0.5	-0.5	-1.0	-0.8	-1.1	-0.1	-0.1	-1.1
Mother’s age at death	2.6	3.2	6.0	1.5	0.2	2.0	-0.1	1.0	2.4	1.9	2.2	-1.3	-2.0	1.9	2.5	2.1	2.4	1.0	1.1	2.3
Financial situation satisfaction	1.5	1.8	4.5	1.4	0.0	1.3	-1.2	0.1	2.1	2.1	1.0	-0.3	-1.3	1.6	1.7	1.3	1.8	-0.3	-0.1	2.0
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.5	-1.0	-0.9	-1.1	0.6	-1.1	-0.5	0.4	-1.2	1.5	0.8	-1.1	-0.9	-1.2	-0.7	-1.9	-1.6	-0.2
Commuting to job workplace: Public transport	1.2	1.4	3.0	1.7	-0.4	1.5	-0.0	0.7	1.0	0.4	1.7	-1.2	-1.0	1.2	1.3	1.5	1.3	1.5	1.3	1.0
Eye problems/disorders: Glaucoma	1.6	1.9	3.4	1.4	0.2	1.4	-0.8	1.4	1.2	0.2	1.5	-1.6	-1.9	1.3	1.5	1.5	1.3	1.8	1.8	1.0
Medication: Blood pressure	2.2	4.2	8.6	2.3	-0.2	2.0	-2.9	1.6	2.0	0.8	2.2	-1.8	-2.6	1.9	2.3	2.3	2.1	1.8	2.1	2.0
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.7	1.4	-0.6	1.3	-1.6	1.5	1.0	-0.0	1.3	-1.5	-1.4	1.5	1.1	1.4	1.0	1.6	1.6	0.8
Supplements: Fish oil (including cod liver oil)	2.2	2.9	9.0	-2.6	-1.4	-1.2	2.5	-3.0	-0.9	1.2	-0.1	2.4	1.9	-1.4	-0.8	-1.2	-0.6	-1.8	-2.2	-0.1
High cholesterol (Self-reported)	0.4	0.7	2.0	-1.4	-1.2	-0.9	-0.2	-1.1	-0.6	0.3	-0.4	1.1	0.5	-1.1	-0.4	-0.9	-0.6	-1.0	-0.9	-0.3
Medication: Bendroflumethiazide	0.7	1.1	6.0	-0.1	-0.3	0.5	-2.4	-0.7	1.0	1.6	1.0	0.4	-1.3	0.6	1.3	0.6	0.9	-0.3	-0.2	1.4
Medication: Paracetamol	0.1	0.2	0.5	0.1	-0.1	0.2	-0.1	0.0	0.6	0.7	0.4	-0.1	-0.6	0.3	0.7	0.4	0.6	-0.1	0.1	0.7
Medication: Lisinopril	0.7	0.9	1.9	-0.9	-0.9	-1.2	1.0	-0.8	-1.3	-1.1	-0.7	0.7	0.2	-1.4	-0.9	-1.1	-1.1	-0.3	-0.0	-1.0
Medication: Atorvastatin	0.8	0.9	4.2	-0.0	0.3	-0.4	-1.1	0.8	-1.0	-2.0	-0.9	-0.9	-0.7	-0.4	-0.5	-0.4	-0.9	1.1	1.4	-1.4
Illnesses of father: High blood pressure	0.6	0.8	4.2	0.4	-0.3	-0.2	-2.0	0.3	-0.4	-1.2	-0.5	-0.9	-1.5	0.2	0.2	-0.1	-0.4	0.9	1.3	-0.7
Alcohol drinker status: Never	0.4	0.5	1.2	-0.5	0.6	-0.8	0.6	0.1	-0.8	-0.8	-1.1	0.1	0.7	-0.3	-0.9	-0.8	-1.0	-0.3	-0.4	-1.1
Ever smoked	0.1	0.2	1.2	1.1	0.2	0.3	0.4	1.0	0.4	-0.3	-0.1	-0.5	0.1	0.2	-0.0	0.4	0.2	0.1	0.3	0.1
Basal metabolic rate	0.8	4.7	7.5	2.4	2.1	2.7	-0.4	2.3	2.6	1.8	2.4	-1.6	-1.5	2.5	2.4	2.7	2.6	1.4	1.2	2.5
Leg fat percentage (left)	0.5	1.8	4.3	1.6	2.0	1.4	-2.1	1.6	1.2	0.4	1.1	-1.3	-0.9	1.4	1.2	1.4	1.3	1.2	1.1	0.9
Arm fat-free mass (left)	1.3	6.6	11.1	3.2	2.3	3.3	-0.8	3.3	2.8	1.3	2.7	-2.3	-1.7	3.0	2.5	3.2	2.8	2.3	2.0	2.5
Number of operations (self-reported)	1.0	1.5	4.3	0.4	-0.2	1.5	-0.6	0.2	1.1	1.1	2.1	-0.9	-1.4	1.5	1.7	1.5	1.3	1.5	1.0	1.2
Average weekly beer plus cider intake	0.2	0.3	0.8	0.5	-0.5	0.1	-0.2	0.7	-0.3	-0.9	-0.3	-0.8	-0.1	-0.2	-0.1	-0.1	-0.3	0.7	0.7	-0.8
Irritability	0.8	1.4	3.6	-1.3	-0.2	-0.9	1.8	-1.4	-0.2	1.1	-0.3	1.9	1.4	-0.8	-0.6	-0.8	-0.2	-1.8	-1.9	0.3
Risk taking	6.8	9.9	19.1	3.8	-0.8	3.4	-1.8	2.7	2.6	0.1	3.0	-4.0	-4.4	3.6	3.4	3.5	2.8	4.0	4.1	1.9
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.6	0.2	-0.6	0.5	-0.1	0.7	-0.1	-0.5	0.6	-0.9	-1.1	0.6	0.4	0.6	0.1	1.3	1.1	0.1
Fractured/broken bones in last 5 years	0.9	1.1	2.1	-1.1	-1.1	-1.3	0.8	-1.0	-1.4	-1.1	-1.4	0.4	0.1	-0.8	-1.1	-1.4	-1.4	-0.6	-0.3	-1.5
Age started oral contraceptive pill	0.6	0.8	2.2	0.5	0.0	1.0	-1.0	0.4	0.9	0.6	1.5	-0.6	-0.9	0.5	1.2	1.1	1.1	1.1	1.0	0.9
Diastolic blood pressure, automated reading	9.3	28.9	43.2	5.5	1.6	6.3	-4.2	4.5	6.3	4.1	6.1	-4.4	-5.7	6.4	6.6	6.5	6.4	4.2	4.0	6.0
Ever depressed for a whole week	0.1	0.2	0.4	-0.0	-0.5	0.2	0.0	-0.2	0.6	0.6	0.2	-0.0	-0.7	0.0	0.6	0.3	0.4	-0.2	0.1	0.6
Unable to work because of sickness or disability	0.3	0.4	1.6	1.1	0.6	0.7	1.1	1.3	0.4	-0.2	0.2	-0.7	0.1	0.8	0.2	0.6	0.4	0.6	0.4	0.2
Commuting to job workplace: Cycle	0.6	0.8	1.8	0.4	-0.8	0.8	-0.4	0.4	0.7	0.1	1.0	-1.1	-1.2	0.9	1.0	1.0	0.7	1.4	1.2	0.5
Myopia	0.4	0.6	2.5	-0.2	-1.6	0.1	-0.3	-0.9	0.7	1.4	0.5	0.9	0.2	-0.1	0.4	0.1	0.7	-0.9	-0.9	1.0
Vascular/heart problems diagnosed by doctor	0.6	1.7	8.4	-1.1	-0.2	-1.0	2.9	-1.0	-0.4	0.2	-1.3	1.4	1.6	-1.2	-1.2	-1.1	-0.6	-1.8	-1.6	-0.4
Cholesterol lowering medication	0.2	0.3	1.6	0.0	-1.2	0.1	-0.3	-0.4	0.4	0.6	0.3	0.3	-1.0	0.0	0.6	0.2	0.4	-0.2	0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.3	-0.2	1.8	-0.6	-0.7	-0.2	-0.6	-0.8	-0.5	-0.4	-0.5	-0.6	0.0	-0.5	-0.5	0.4	0.6	-0.9
Pain experienced in last month	0.3	0.5	1.9	0.4	0.4	0.3	-0.5	0.3	-0.2	-0.7	0.7	-1.0	-1.1	0.2	0.5	0.4	0.1	1.4	1.3	-0.4
Supplements: Calcium	1.6	1.7	5.0	0.2	-0.8	1.5	-0.7	-0.2	1.7	2.2	2.1	0.1	-0.5	1.0	1.8	1.5	1.8	0.3	-0.1	2.1
Basal cell carcinoma (self-reported)	2.0	2.3	4.0	-2.0	-1.9	-1.8	1.1	-1.2	-1.9	-1.3	-1.6	1.1	1.2	-1.9	-1.5	-1.7	-1.8	-0.8	-0.7	-1.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	3.1	-0.1	1.8	-0.3	-0.3	-0.3	-0.1	0.1	-0.3	0.5	0.7	-0.8	-0.2	-0.4	-0.1	-0.5	-0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	3.4	0.9	-0.8	1.5	0.1	0.6	1.0	0.6	1.9	-1.5	-1.3	1.6	1.5	1.6	1.2	1.8	1.3	0.9
Heart disease (siblings)	0.3	0.3	1.8	-1.4	-0.8	-0.5	-0.0	-0.8	-0.2	0.5	-0.3	0.6	0.3	-0.4	-0.0	-0.5	-0.2	-0.7	-0.8	-0.1
Alcohol drinker status: Previous	0.6	0.7	2.7	0.8	-0.6	0.6	-1.7	1.4	-0.3	-1.0	0.5	-1.0	-0.1	0.5	-0.2	0.6	-0.2	1.5	1.1	-0.4
Pack years of smoking	0.4	0.6	1.9	0.8	0.3	0.4	-0.8	0.9	-0.4	-1.1	0.5	-1.2	-0.2	0.4	-0.1	0.5	-0.2	1.4	1.2	-0.5
Impedance of whole body	1.8	9.2	15.7	-3.8	-2.4	-3.9	1.4	-4.0	-3.6	-1.6	-2.9	2.8	1.8	-3.6	-2.9	-3.8	-3.4	-2.3	-2.2	-3.1
Leg fat mass (left)	0.7	2.5	3.5	1.7	1.8	1.8	-1.7	1.6	1.8	1.2	1.7	-1.2	-1.3	1.8	1.8	1.8	1.9	1.1	1.0	1.7
Arm predicted mass (left)	1.4	7.0	11.5	3.1	2.0	3.4	-0.5	3.2	3.0	1.6	2.9	-2.3	-1.9	3.1	2.7	3.4	3.0	2.2	1.9	2.8