TWAS hub - STIL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.106	0.039	0.00170	0.124	NA	0.092	NA	0.100	2.5e-07	NA	9.6e-06	NA	3.8e-06
2	GTEx	Cells EBV-transformed lymphocytes	0.210	0.067	0.00069	0.115	NA	0.084	NA	0.117	1.4e-04	NA	1.1e-03	NA	1.3e-04
3	TCGA	Thyroid Carcinoma	0.046	0.025	0.00280	0.010	0.023	0.007	NA	0.012	3.5e-02	0.0025	6.3e-02	NA	2.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Age when periods started (menarche)	7.3	17.6	24.3	4.9	4.9	2.2
Noisy workplace	6.3	7.8	10.3	-3.2	-3.2	-1.7
Falls in the last year	6.2	8.4	11.6	-3.4	-3.3	-1.6
Pulse wave reflection index	4.7	5.8	7.6	-2.2	-2.3	-2.8
Pulse wave peak to peak time	4.7	5.6	6.1	2.5	2.3	2.3
Pulse wave Arterial Stiffness index	4.6	5.3	6.2	-2.3	-2.1	-2.5
Townsend deprivation index at recruitment	4.4	6.2	8.2	2.9	2.4	2.2
Heart disease (mother)	4.4	5.3	6.5	2.4	2.5	2.0
Average weekly spirits intake	3.9	4.8	6.6	-2.1	-2.6	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	3.9	5.1	5.3	2.3	2.2	2.3
Prostate Cancer	3.6	5.1	6.8	2.5	2.6	1.4
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	3.7	1.5	1.9	1.9
Osteoporosis (self-reported)	2.8	3.4	6.1	1.4	1.5	2.5
Time employed in main current job	2.7	3.2	5.0	1.5	1.5	2.2
Exposure to tobacco smoke at home	2.7	3.0	6.1	1.1	1.3	2.5
Qualifications: nursing, teaching	2.7	4.1	6.5	-2.2	-2.5	-1.0
Forced vital capacity (FVC), Best measure	2.6	9.5	11.5	3.3	3.4	2.5
Supplements: Zinc	2.5	2.7	4.3	1.7	2.1	0.8
Alcohol drinker status: Previous	2.5	2.8	3.0	-1.7	-1.7	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	5.9	1.5	1.8	2.4
Wheeze or whistling in the chest in last year	2.4	4.3	5.9	1.8	1.9	2.4
Medication: Seretide 50 evohaler	2.4	2.8	3.1	1.6	1.7	1.7
Blood Red Count	2.3	22.3	40.1	-3.5	-3.8	-6.3
Stomach or abdominal pain in last month	2.3	2.9	4.8	1.9	2.2	0.4
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	3.5	-1.7	-1.9	-1.4
Handedness (chirality/laterality): Left-handed	2.3	2.7	4.2	2.1	2.0	0.3
Alzheimer’s Disease (in mother)	2.2	2.6	2.7	-1.6	-1.6	-1.6
Cardiovascular Disease	2.2	7.3	10.2	2.1	2.7	3.2
Ever highly irritable/argumentative for 2 days	2.2	2.7	3.0	-1.7	-1.7	-1.4
Lupus	2.1	3.1	4.2	-2.0	-2.0	-1.1
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	4.8	1.6	2.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.8	7.6	2.7	2.8	2.4
Mouth/teeth dental problems: Loose teeth	2.1	2.5	3.2	1.8	1.5	1.4
Long-standing illness, disability or infirmity	2.1	3.1	4.3	1.2	1.9	2.1
Number of operations (self-reported)	2.1	3.1	6.1	-1.5	-1.1	-2.5
Maternal smoking around birth	2.0	2.9	4.3	2.1	1.9	0.8
Gout (self-reported)	2.0	2.8	3.4	-1.7	-1.4	-1.9
Average weekly beer plus cider intake	2.0	2.9	4.8	-1.8	-2.2	-0.9
Age at First Birth	1.9	2.8	3.1	1.7	1.6	1.8
Serious illness, injury or assault to yourself	1.9	2.3	3.8	1.6	1.9	0.7
Impedance of leg (left)	1.9	9.0	10.4	2.9	2.9	3.2
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.1	-1.8	-1.7	-1.0
Pain all over the body in last month	1.8	1.9	5.4	0.2	0.5	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	5.5	2.3	2.2	0.9
Supplements: Glucosamine	1.7	2.2	2.4	-1.6	-1.6	-1.3
Forced vital capacity (FVC)	1.7	6.5	8.4	2.8	2.9	1.9
Emphysema/chronic bronchitis	1.7	1.9	4.8	0.6	0.8	2.2
Diabetes diagnosed by doctor	1.7	2.8	4.9	1.2	1.4	2.2
Number of self-reported non-cancer illnesses	1.7	2.9	5.0	1.7	2.2	1.0
Blood Eosinophil Count	1.6	12.6	13.7	-3.6	-3.4	-3.7
Hearing difficulty/problems with background noise	1.6	2.5	3.4	1.8	1.8	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	2.9	-1.7	-1.6	-0.6
Commuting to job workplace: Walk	1.6	1.8	2.6	1.5	1.6	0.7
Financial situation satisfaction	1.6	2.0	3.5	-1.9	-1.4	-0.6
Supplements: Calcium	1.6	1.8	2.3	1.5	1.4	1.0
Irritable Bowel Disease (IBD)	1.5	3.5	4.7	2.2	2.2	1.0
Medication: Lansoprazole	1.5	1.7	2.4	-1.6	-1.3	-1.0
Past tobacco smoking	1.4	2.5	3.9	1.4	1.3	2.0
Had other major operations	1.4	1.7	2.7	-1.6	-1.2	-1.0
Worrier / anxious feelings	1.4	2.6	3.4	1.6	1.8	1.3
Asthma	1.4	2.8	3.1	1.8	1.7	1.6
Depression (self-reported)	1.4	1.7	3.0	1.3	1.7	0.5
Lung cancer (father)	1.4	1.6	2.5	1.6	1.3	0.8
Smoking status: Previous	1.4	2.1	2.7	-1.6	-1.4	-1.3
Mean Putamen Volume	1.3	1.5	2.0	1.3	1.4	-0.9
Blood Platelet Count	1.3	15.0	17.8	-3.9	-3.5	-4.2
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.6	1.2	1.5	1.9
Hayfever, allergic rhinitis or eczema	1.3	2.7	3.0	-1.7	-1.7	-1.6
Illnesses of siblings	1.3	1.8	2.3	-1.3	-1.2	-1.5
Forced expiratory volume in 1-second (FEV1)	1.3	4.2	5.2	2.1	2.3	1.7
Illnesses of mother	1.3	1.6	2.3	1.2	1.0	1.5
Standing height	1.3	12.8	21.2	4.1	4.6	0.9
Migraine (self-reported)	1.3	1.6	3.5	0.8	0.8	1.9
Impedance of whole body	1.3	6.7	7.5	2.7	2.7	2.3
Schizophrenia (2018)	1.2	2.4	2.8	1.6	1.7	1.4
Ulcerative Colitis (UC)	1.2	2.3	3.6	1.9	1.7	0.7
Height	1.2	23.3	41.3	5.3	6.4	0.4
Respiratory disease	1.2	2.6	3.3	1.7	1.8	1.2
Sensitivity / hurt feelings	1.2	2.1	4.3	0.7	1.2	2.1
Medication: Co-codamol	1.2	1.4	1.8	1.3	1.4	-0.7
Asthma (self-reported)	1.2	2.5	2.8	1.7	1.6	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	3.0	1.7	1.7	1.3
Guilty feelings	1.2	1.8	2.1	1.2	1.3	1.5
Wears glasses or contact lenses	1.2	1.4	2.7	-1.6	-1.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.7	1.3	1.6	0.1
Schizophrenia vs Biploar Disorder	1.1	1.5	2.8	1.0	0.7	1.7
Crohns Disease (2017)	1.1	2.4	2.9	1.6	1.7	1.4
Lung FVC	1.1	5.5	6.7	2.0	2.4	2.6
Impedance of leg (right)	1.1	5.3	6.2	2.2	2.2	2.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.4	-1.1	-0.8	-1.5
Impedance of arm (right)	1.1	5.0	7.0	2.6	2.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.7	-1.2	-1.3	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.0	-0.1	0.1	-2.0
Illnesses of father: Heart disease	1.1	1.6	2.6	-1.1	-1.0	-1.6
Average weekly red wine intake	1.1	1.6	2.5	-1.6	-1.5	-0.3
Medication: Paracetamol	1.1	1.7	2.3	-1.3	-1.0	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.2	1.0	1.1	1.5
Neuroticism (Nagel 2018)	1.0	2.3	2.5	1.5	1.6	1.5
Neuroticism	1.0	2.3	2.7	1.5	1.6	1.4
Taking other prescription medications	1.0	1.5	2.0	1.2	1.4	1.0
Diabetes (self-reported)	1.0	1.5	3.0	0.7	1.1	1.7
Loud music exposure frequency	1.0	1.1	2.2	-1.5	-1.0	0.5
Medication: Paracetamol	1.0	1.7	2.1	-1.4	-1.3	-1.1
Medication: Omeprazole	1.0	1.2	2.2	1.1	1.5	0.6
Worry (Nagel 2018)	0.9	1.9	2.7	1.6	1.6	0.6
Schizophrenia (2014)	0.9	2.0	2.5	1.6	1.3	1.3
BMI	0.9	5.2	7.2	-2.7	-2.4	-1.6
Systolic Blood Pressure	0.9	4.3	6.4	2.5	2.5	0.6
Hair/balding pattern: Pattern 4	0.9	2.1	2.8	1.0	1.6	1.7
Major Depression (MDD)	0.8	1.0	1.2	1.0	1.1	0.9
LDL Cholesterol	0.8	1.2	1.9	-1.3	-1.4	-0.2
Heel T-Score	0.8	6.5	7.9	2.5	2.8	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.3	-1.1	-0.9	-1.8
Body mass index (BMI)	0.8	3.5	4.3	-2.1	-1.9	-1.6
Impedance of arm (left)	0.8	3.6	5.2	2.3	2.2	0.7
Exposure to tobacco smoke outside home	0.8	1.0	1.6	1.2	1.3	0.1
Comparative height size at age 10	0.8	4.4	7.0	2.3	2.6	0.9
Average weekly champagne plus white wine intake	0.8	1.1	1.5	-1.1	-1.2	-0.8
Commuting to job workplace: Cycle	0.8	1.0	1.4	-1.1	-1.2	0.6
Bipolar Disorder (2011)	0.7	0.7	0.8	0.8	0.8	0.9
HDL Cholesterol	0.7	1.1	1.7	1.2	1.3	0.5
Allergy or Eczema	0.7	1.9	2.4	-1.5	-1.6	-1.1
Relative age of first facial hair	0.7	1.5	2.7	-1.0	-0.9	-1.7
Alcohol usually taken with meals	0.7	1.2	1.4	-1.2	-0.9	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	-1.0	-1.2	-0.2
Tense / ‘highly strung’	0.7	1.1	1.5	1.2	1.2	0.7
Blood clot in the leg (DVT)	0.7	1.0	1.5	0.7	0.9	1.2
Number of children fathered	0.7	0.8	0.8	-0.9	-0.9	-0.9
Medication for pain relief, constipation, heartburn	0.7	1.2	1.7	1.3	1.1	0.9
Medication: Atorvastatin	0.7	0.8	1.1	-0.8	-1.0	-0.8
Unable to work because of sickness or disability	0.7	0.9	1.4	1.1	1.2	-0.3
Depressed Affect (Nagel 2018)	0.6	1.3	2.2	0.7	1.1	1.5
Crohns Disease (2012)	0.6	1.0	1.9	0.8	0.7	1.4
Hand grip strength (right)	0.6	1.8	2.5	1.6	1.5	-0.7
Neuroticism score	0.6	1.3	2.0	1.0	1.4	1.0
Hair/balding pattern: Pattern 3	0.6	0.9	1.1	0.9	0.9	1.0
Pulse rate, automated reading	0.6	1.9	2.8	-1.6	-1.7	-0.7
Number of full sisters	0.6	0.8	2.0	-0.3	-0.5	-1.4
Medication: Aspirin	0.6	0.8	1.5	-1.2	-1.0	-0.2
Eye problems/disorders: Cataract	0.6	0.7	0.8	-0.8	-0.9	-0.8
Medication for cholesterol	0.6	0.9	1.3	-0.6	-1.1	-1.1
Basal cell carcinoma (self-reported)	0.6	0.8	1.7	-0.4	-0.6	-1.3
Heart disease (siblings)	0.6	0.7	1.0	0.7	1.0	0.9
Bipolar Disorder or Schizophrenia	0.5	1.3	2.0	1.3	1.4	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	2.0	-0.3	-0.3	-1.4
Breast Cancer	0.5	1.3	2.4	0.9	1.6	-0.8
Coronary Artery Disease (CAD)	0.5	0.5	1.0	1.0	0.6	0.4
Neuroticism (2016)	0.5	0.8	1.3	-1.1	-1.0	-0.1
Ulcerative Colitis	0.5	0.8	2.2	-0.2	-0.1	-1.5
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	-0.4	-0.6	-1.0
Diabetes (mother)	0.5	0.7	1.2	-1.1	-0.9	-0.0
Severe depression (siblings)	0.5	0.5	1.0	-0.6	-0.5	-1.0
Medication: Levothyroxine sodium	0.5	0.8	1.5	-1.2	-1.0	-0.2
Heart attack	0.5	0.6	1.4	0.3	0.7	-1.2
Number of full brothers	0.5	0.6	0.9	-0.9	-0.9	-0.1
Alcohol intake frequency.	0.5	1.1	1.5	0.8	1.0	1.2
Knee pain experienced in last month	0.5	0.7	1.2	-0.6	-0.7	-1.1
Mood swings	0.5	1.0	1.7	0.5	1.0	1.3
Medication: Aspirin	0.5	0.7	1.2	-1.1	-0.8	-0.2
Miserableness	0.5	0.8	1.3	0.7	1.1	0.8
Fasting Glucose	0.4	0.5	0.6	0.7	0.5	0.8
Hand grip strength (left)	0.4	1.2	1.5	1.2	1.2	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-0.7	-0.9	-0.3
Systolic blood pressure, automated reading	0.4	1.1	1.8	1.2	1.3	0.1
Fed-up feelings	0.4	0.8	1.1	0.7	0.9	1.1
Qualifications: CSEs or equivalent	0.4	0.5	1.5	0.0	0.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	-0.7	-0.4	-1.0
Had menopause	0.4	0.5	0.7	-0.8	-0.9	0.2
Fluid intelligence score	0.4	0.8	1.0	0.8	0.9	1.0
Hip circumference	0.4	1.7	4.8	-0.6	-0.1	-2.2
Alcohol intake versus 10 years previously	0.4	0.5	1.2	0.4	0.5	-1.1
Father’s age at death	0.4	0.5	0.7	0.9	0.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	0.4	0.8	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.9	-0.6	-0.6	1.0
High blood pressure (siblings)	0.4	0.6	1.0	0.9	0.4	1.0
Medication: Allopurinol	0.4	0.5	1.1	-0.5	-0.4	-1.1
Leg pain on walking	0.4	0.6	0.6	-0.7	-0.8	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.5	0.7	0.6	0.5
Hypertension (Self-reported)	0.4	1.1	2.0	0.9	1.4	0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.9	-0.5	-0.9
Back pain experienced in last month	0.4	0.5	1.1	-1.0	-0.7	0.2
Osteoarthritis (self-reported)	0.4	0.5	1.0	-0.5	-0.5	-1.0
Medication: Gliclazide	0.4	0.4	0.7	0.7	0.8	0.3
Ever smoked	0.4	0.6	1.8	-0.3	-0.2	-1.3
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.2	0.3	0.6	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.9	-0.6	-0.9	-1.4
Ovarian Cancer	0.3	0.4	0.8	-0.2	-0.5	0.9
Triglycerides	0.3	0.5	0.8	-0.9	-0.8	0.1
Waist Hip Ratio (WHR)	0.3	1.5	4.3	0.5	0.1	2.1
Angina	0.3	0.4	1.2	-0.3	0.1	1.1
Medication: Metformin	0.3	0.5	0.6	0.7	0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.7	0.8	-0.4
Waist circumference	0.3	1.2	1.4	-1.2	-0.9	-1.2
Number of incorrect matches in round	0.3	0.4	1.3	-0.1	-0.2	1.1
Nervous feelings	0.3	0.5	1.1	0.7	1.1	-0.0
Medication: Ramipril	0.3	0.4	0.8	-0.1	0.5	-0.9
Medication: Simvastatin	0.3	0.4	1.3	-0.0	-0.0	1.1
Number of live births	0.3	0.5	0.8	-0.9	-0.6	-0.5
Prospective memory result	0.3	0.3	0.6	0.4	0.5	0.8
Arm fat mass (right)	0.3	1.2	1.7	-1.0	-0.9	-1.3
Birth weight of first child	0.3	0.6	0.7	-0.8	-0.7	-0.8
Comparative body size at age 10	0.3	0.7	1.2	-1.1	-0.8	-0.5
Angina (self-reported)	0.3	0.4	1.1	-0.4	0.0	1.0
Medication: Ibuprofen	0.3	0.3	0.7	-0.5	-0.8	-0.3
Suffer from ‘nerves’	0.3	0.4	0.6	0.5	0.8	-0.7
Chest pain or discomfort	0.3	0.4	0.6	0.4	0.8	0.5
Family relationship satisfaction	0.3	0.3	0.6	0.5	0.8	0.4
Illnesses of siblings: Diabetes	0.3	0.3	0.4	0.6	0.5	0.6
Arm fat percentage (left)	0.3	1.4	1.6	-1.1	-1.1	-1.3
Ever had bowel cancer screening	0.3	0.4	0.4	-0.7	-0.6	-0.5
Friendships satisfaction	0.3	0.3	0.6	0.5	0.8	-0.3
Medication: Bendroflumethiazide	0.3	0.4	0.8	0.5	0.9	0.4
Medication: Lisinopril	0.3	0.3	0.6	0.4	0.5	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.7	-0.5	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.1	-0.1	-0.3	1.1
Diastolic blood pressure, automated reading	0.3	0.9	2.0	0.5	0.6	-1.4
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.7	-0.8	-1.3	-0.5
Pain experienced in last month	0.3	0.5	1.3	0.2	0.1	-1.2
Depression (Nagel 2018)	0.2	0.4	0.5	0.5	0.6	0.7
Blood White Count	0.2	1.1	2.5	0.8	0.6	1.6
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.9	-0.6	0.4
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.2	-0.0	0.8
Diabetes (father)	0.2	0.2	0.4	-0.3	-0.5	-0.6
Leg fat-free mass (left)	0.2	1.2	3.6	-0.2	0.1	-1.9
Current tobacco smoking	0.2	0.4	0.6	0.7	0.8	0.1
Average weekly fortified wine intake	0.2	0.3	0.4	-0.7	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.6	0.0	0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.6	-0.3	-0.3	-0.8
High blood pressure	0.2	0.5	1.1	0.6	1.0	0.4
High blood pressure (mother)	0.2	0.3	0.6	-0.6	-0.1	-0.8
Leg predicted mass (left)	0.2	1.0	3.0	-0.0	0.3	-1.7
Financial difficulties in last 2 years	0.2	0.3	0.5	0.4	0.7	0.6
Arm fat percentage (right)	0.2	1.0	1.2	-1.0	-0.9	-1.1
Trunk fat-free mass	0.2	1.3	2.4	1.1	1.6	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.2	0.5	-0.6
Medication: Cholesterol lowering	0.2	0.3	0.9	0.0	-0.1	1.0
Trunk predicted mass	0.2	1.3	2.6	1.1	1.6	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.3	-0.6	-0.4	-0.5
Glaucoma (self-reported)	0.2	0.2	0.4	-0.4	-0.6	-0.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.1	-0.7	0.3
Age at first live birth	0.2	0.3	0.4	0.4	0.5	0.6
Health satisfaction	0.2	0.2	0.6	0.0	0.3	-0.8
Medication: Blood pressure	0.2	0.3	0.5	0.3	0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.1	0.1	-0.8
Had major operations	0.2	0.3	0.8	-0.3	-0.0	-0.9
Supplements: Vitamin C	0.2	0.2	0.6	-0.1	-0.0	0.8
Leg fat-free mass (right)	0.2	0.9	2.5	0.1	0.5	-1.6
Loneliness, isolation	0.2	0.2	0.5	0.2	0.3	0.7
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.4	0.4	0.7
Leg predicted mass (right)	0.2	0.9	2.6	0.1	0.5	-1.6
Arm fat mass (left)	0.2	1.0	1.6	-0.9	-0.8	-1.3
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.5	-0.5	0.4
Medication: Blood pressure	0.2	0.3	0.5	0.1	0.6	-0.7
High cholesterol (Self-reported)	0.2	0.4	0.5	-0.5	-0.7	0.5
Myopia	0.2	0.3	0.8	0.1	-0.2	-0.9
Bipolar Disorder (2018)	0.1	0.2	0.5	0.1	0.2	-0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	0.2	-0.2
Reaction Time	0.1	0.2	0.3	0.5	0.4	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.5	-0.7	-0.7	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.2	-0.1	-0.4
HbA1C	0.1	0.2	0.2	-0.5	-0.3	0.4
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.0	-0.3	-0.7
Smoking Status	0.1	0.3	0.9	-0.4	-0.2	-0.9
Lung FEV1/FVC ratio	0.1	0.6	1.0	-1.0	-0.7	-0.5
Chronotype (morning person)	0.1	0.2	0.3	-0.3	-0.3	0.5
Tanning	0.1	1.0	1.3	-0.9	-1.1	-0.8
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.1	0.5	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.4	0.4	-0.0
Pack years adult smoking proportion	0.1	0.1	0.2	0.3	0.2	-0.4
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	-0.3	-0.4
Sitting height	0.1	0.7	1.5	0.7	1.2	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	-0.4	-0.6	0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.1	0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.3	0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.4	0.5	-0.1
Qualifications: None of the above	0.1	0.2	0.5	0.3	0.7	-0.0
Mouth/teeth dental problems	0.1	0.1	0.3	0.1	-0.3	-0.6
Allergy	0.1	0.2	0.4	0.6	0.5	-0.3
Weight	0.1	0.4	1.2	-0.2	0.2	-1.1
Pulse rate	0.1	0.1	0.1	-0.2	-0.3	0.4
Happiness	0.1	0.1	0.3	-0.5	0.1	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	-0.5	-0.5	0.2
Length of working week for main job	0.1	0.1	0.2	0.4	0.3	0.3
Breastfed as a baby	0.1	0.1	0.2	0.4	0.4	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.8	-0.6	0.3
Headache pain in last month	0.1	0.2	0.3	-0.6	-0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.3	0.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	-0.7	-0.5	0.2
Medication: Amlodipine	0.1	0.2	0.5	0.1	0.1	0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.5	0.3	0.4
Birth weight	0.1	0.3	0.7	-0.5	-0.2	-0.8
Leg fat percentage (right)	0.1	0.2	0.4	-0.6	-0.4	-0.2
Arm fat-free mass (right)	0.1	0.3	0.4	0.3	0.7	-0.6
Worry too long after embarrassment	0.1	0.2	0.5	0.3	0.3	0.7
Qualifications: College or University degree	0.1	0.3	0.6	-0.3	-0.5	-0.8
Mean time to correctly identify matches	0.1	0.2	0.4	0.3	0.2	0.6
Leg fat mass (right)	0.1	0.2	0.4	-0.5	-0.3	-0.6
Arm predicted mass (right)	0.1	0.3	0.4	0.2	0.6	-0.6
Overall health rating	0.1	0.3	0.6	0.2	0.8	-0.3
Age at last live birth	0.1	0.1	0.2	-0.2	-0.5	-0.2
Whole body fat-free mass	0.1	0.7	1.0	0.6	1.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.1	0.1	-0.5
Mineral and other dietary supplements	0.1	0.1	0.1	0.3	0.4	0.3
Breast cancer (self-reported)	0.1	0.1	0.2	-0.3	-0.5	-0.3
Smoking status: Current	0.1	0.2	0.4	0.5	0.6	-0.2
Whole body water mass	0.1	0.7	1.0	0.5	0.9	-1.0
Hearing aid user	0.1	0.1	0.3	-0.0	-0.2	0.6
Mother’s age at death	0.1	0.1	0.3	0.6	0.2	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.1	0.2	0.3	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.3	-0.4	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.2	-0.4	-0.4	-0.4
Alcohol drinker status: Never	0.1	0.1	0.2	-0.3	-0.4	0.3
Basal metabolic rate	0.1	0.7	1.2	0.4	0.8	-1.1
Arm fat-free mass (left)	0.1	0.3	0.5	0.3	0.7	-0.5
Risk taking	0.1	0.1	0.2	-0.5	-0.4	-0.1
Age started oral contraceptive pill	0.1	0.2	0.3	0.4	-0.1	0.6
Cholesterol lowering medication	0.1	0.2	0.4	-0.3	-0.1	0.6
Rheumatoid Arthritis	0.0	0.1	0.1	0.1	0.0	0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.1	-0.1	0.2
Hair Pigment	0.0	0.2	0.7	-0.8	0.1	-0.2
Number of treatments/medications taken	0.0	0.1	0.1	-0.3	0.1	0.3
Vitamin and mineral supplements	0.0	0.0	0.0	-0.0	-0.0	0.1
Trunk fat percentage	0.0	0.1	0.1	-0.3	-0.1	-0.3
Relative age voice broke	0.0	0.0	0.0	0.0	-0.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	-0.2	-0.2	-0.0
Medication: Atenolol	0.0	0.0	0.0	-0.2	-0.1	0.0
Trunk fat mass	0.0	0.1	0.3	-0.1	0.2	-0.6
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	-0.3	-0.2	0.4
Body fat percentage	0.0	0.1	0.1	-0.4	-0.2	-0.2
Shortness of breath walking on level ground	0.0	0.0	0.1	-0.1	-0.0	-0.3
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.3	0.1	0.1
Neck or shoulder pain in last month	0.0	0.0	0.0	0.0	0.1	-0.1
Whole body fat mass	0.0	0.2	0.4	-0.4	-0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	0.0	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.1	0.2	-0.3
Illnesses of father: High blood pressure	0.0	0.0	0.0	-0.1	-0.1	-0.1
Leg fat percentage (left)	0.0	0.1	0.2	-0.4	-0.2	0.0
Irritability	0.0	0.0	0.1	-0.3	-0.0	0.1
Ever depressed for a whole week	0.0	0.0	0.1	0.1	0.3	-0.2
Pack years of smoking	0.0	0.0	0.1	0.3	0.2	-0.2
Leg fat mass (left)	0.0	0.1	0.3	-0.3	-0.1	-0.6
Arm predicted mass (left)	0.0	0.2	0.3	0.1	0.5	-0.6

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