TWAS hub - STK16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0136	0.0074	0.0170	0.019	0.003	0.013	0.008	0.016	6.6e-07	0.02900	2.8e-05	0.0011	4.0e-06
2	TCGA	Brain Lower Grade Glioma	0.0459	0.0262	0.0034	0.005	0.026	0.026	NA	0.018	8.5e-02	0.00053	5.3e-04	NA	3.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Depressed Affect (Nagel 2018)	10.5	22.1	27.5	-4.1	-5.2
Alcohol usually taken with meals	9.1	14.7	22.4	2.6	4.7
Frequency of depressed mood in last 2 weeks	6.8	9.6	11.9	-2.7	-3.4
Mood swings	6.6	11.9	12.3	-3.4	-3.5
Loneliness, isolation	6.1	8.5	15.1	-1.3	-3.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.7	6.8	12.2	-1.1	-3.5
Fed-up feelings	5.5	10.0	13.2	-2.6	-3.6
Depression (Nagel 2018)	5.4	8.1	11.7	-2.1	-3.4
Average weekly beer plus cider intake	5.1	7.4	10.4	-2.1	-3.2
Father’s age at death	4.7	6.2	8.7	3.0	1.9
Neuroticism (Nagel 2018)	4.5	10.6	14.8	-2.5	-3.9
Age started oral contraceptive pill	4.4	5.6	10.2	0.9	3.2
Miserableness	4.3	7.5	10.2	-2.2	-3.2
Ever taken oral contraceptive pill	4.3	4.7	5.8	2.4	1.9
Health satisfaction	4.2	5.4	7.8	-1.8	-2.8
Medication: Aspirin	4.2	5.6	5.9	2.4	2.3
Bipolar Disorder or Schizophrenia	4.0	9.7	11.2	-3.4	-2.9
Irritability	3.9	6.6	6.8	-2.6	-2.5
Medication: Aspirin	3.8	4.9	6.0	2.5	2.0
Fractured/broken bones in last 5 years	3.5	4.5	5.9	-2.4	-1.8
Schizophrenia (2014)	3.3	7.3	7.8	-2.8	-2.6
Neck or shoulder pain in last month	3.3	4.7	5.3	-2.3	-2.0
Comparative height size at age 10	3.2	17.8	28.9	2.6	5.4
Average weekly red wine intake	3.2	4.8	9.6	0.0	3.1
Medication: Levothyroxine sodium	3.0	5.1	7.1	2.7	1.7
Standing height	3.0	29.4	55.7	1.8	7.5
Medication for hormone replacement therapy	2.9	3.3	4.5	-2.1	-1.4
Illnesses of father: Heart disease	2.9	4.0	4.1	2.0	2.0
Major Depression (MDD)	2.8	3.5	5.9	-1.0	-2.4
Number of incorrect matches in round	2.8	4.7	8.5	-2.9	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	9.2	-0.1	-3.0
Vitamin and mineral supplements	2.6	3.5	5.3	-2.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	5.9	-1.0	-2.4
Pulse rate, automated reading	2.6	8.4	11.5	-2.3	-3.4
Commuting to job workplace: Public transport	2.6	3.1	4.2	1.4	2.1
Height	2.5	47.3	91.8	1.7	9.6
Neuroticism	2.5	6.1	8.6	-1.9	-2.9
Multivitamins +/- minerals	2.5	3.1	3.7	1.9	1.6
Bipolar Disorder (2018)	2.4	3.8	4.2	-2.0	-1.8
Schizophrenia (2018)	2.4	5.1	7.0	-2.7	-1.8
Emphysema/chronic bronchitis	2.4	2.8	4.3	-1.1	-2.1
Alzheimer’s Disease (in father)	2.3	2.5	3.5	-1.9	-1.2
Happiness	2.3	2.8	5.0	-0.8	-2.2
Relative age of first facial hair	2.2	4.4	4.7	-2.2	-2.0
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	4.4	-0.5	-2.1
Medication: Paracetamol	2.2	3.6	4.9	-1.5	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	2.9	-1.7	-1.3
Illnesses of father: High blood pressure	2.1	2.5	2.7	-1.6	-1.6
Rheumatoid Arthritis	1.9	2.7	3.3	-1.4	-1.8
Average weekly fortified wine intake	1.9	2.2	4.4	-0.2	2.1
Neuroticism score	1.9	3.9	5.7	-1.4	-2.4
Alcohol intake frequency.	1.9	4.5	6.6	2.6	-1.6
Alzheimer’s Disease (in mother)	1.8	2.1	3.5	0.8	1.9
Depression (self-reported)	1.8	2.1	2.9	-1.7	-1.2
Medication: Metformin	1.7	2.4	4.0	0.9	2.0
Sitting height	1.7	12.2	22.3	1.4	4.7
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.0	-1.2	-1.7
Headache pain in last month	1.7	3.0	5.9	-0.3	-2.4
Arm predicted mass (right)	1.7	8.5	14.5	1.6	3.8
Commuting to job workplace: Car/motor vehicle	1.7	1.9	1.9	-1.4	-1.4
Cholesterol lowering medication	1.7	2.5	4.1	1.0	2.0
Lupus	1.6	2.5	3.1	-1.4	-1.8
Severe depression (siblings)	1.6	1.8	2.4	1.1	1.5
Trunk fat-free mass	1.6	9.3	15.3	1.8	3.9
Trunk predicted mass	1.6	9.2	15.1	1.8	3.9
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	4.5	0.9	2.1
Unable to work because of sickness or disability	1.6	2.0	2.6	-1.2	-1.6
Whole body fat-free mass	1.5	8.3	12.8	1.9	3.6
Qualifications: nursing, teaching	1.5	2.3	4.5	0.4	2.1
Tinnitus: Yes, now most or all of the time	1.5	1.8	2.2	1.1	1.5
Medication: Paracetamol	1.5	2.2	2.7	-1.3	-1.6
HbA1C	1.4	1.5	3.1	-1.7	-0.0
Breastfed as a baby	1.4	1.7	2.0	1.2	1.4
Medication: Amlodipine	1.4	2.0	2.7	-1.2	-1.7
Arm fat-free mass (right)	1.4	7.3	12.7	1.4	3.6
Supplements: Vitamin C	1.4	1.6	3.2	1.8	0.3
Ever had bowel cancer screening	1.4	1.6	1.7	1.3	1.3
Guilty feelings	1.4	2.2	3.0	-1.1	-1.7
Basal metabolic rate	1.4	7.5	10.8	2.0	3.3
Arm fat-free mass (left)	1.4	6.9	11.6	1.5	3.4
Hypothyroidism (self reported)	1.3	3.0	3.5	1.9	1.6
Leg fat-free mass (left)	1.3	7.0	8.1	2.4	2.8
Townsend deprivation index at recruitment	1.3	1.8	3.5	-0.3	-1.9
Qualifications: CSEs or equivalent	1.3	1.7	3.1	-0.5	-1.8
Leg predicted mass (left)	1.3	7.0	8.1	2.4	2.9
Eye problems/disorders: None of the above	1.3	1.5	3.0	-0.3	-1.7
Medication: Gliclazide	1.3	1.4	2.2	0.8	1.5
Whole body water mass	1.3	7.7	12.0	1.8	3.5
Ever depressed for a whole week	1.3	1.7	2.2	-1.5	-1.1
Sensitivity / hurt feelings	1.2	2.1	3.9	-0.5	-2.0
Gout (self-reported)	1.2	1.7	2.4	-1.6	-1.0
Leg fat-free mass (right)	1.2	6.7	7.5	2.4	2.7
Leg predicted mass (right)	1.2	6.4	7.2	2.4	2.7
Alcohol drinker status: Never	1.2	1.5	3.0	-0.2	-1.7
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	1.9	1.0	1.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.8	0.9	1.4
Medication: Cholesterol lowering	1.1	1.7	3.2	-0.5	-1.8
Number of full brothers	1.1	1.4	1.6	-1.1	-1.3
Age at last live birth	1.1	1.6	2.9	0.5	1.7
Smoking status: Current	1.1	1.7	3.1	-0.5	-1.8
Respiratory disease	1.0	2.3	3.6	1.9	1.0
Hand grip strength (right)	1.0	2.6	4.8	-0.7	2.2
Current tobacco smoking	1.0	1.6	3.1	-0.4	-1.7
Weight	1.0	5.0	6.3	1.9	2.5
Migraine (self-reported)	1.0	1.2	1.3	1.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.0	-0.0	2.0
Commuting to job workplace: Walk	1.0	1.0	1.2	1.1	0.9
Commuting to job workplace: Cycle	1.0	1.2	1.4	-1.0	1.2
Heart disease (siblings)	1.0	1.2	1.6	0.9	1.3
Alcohol drinker status: Previous	1.0	1.1	2.2	1.5	0.1
Arm predicted mass (left)	1.0	5.3	9.5	1.1	3.1
Waist Hip Ratio (WHR)	0.9	4.2	6.5	1.4	2.5
Relative age voice broke	0.9	1.3	1.9	-1.4	-0.9
Trunk fat mass	0.9	4.0	4.1	2.0	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.2	-0.8	-1.5
Exposure to tobacco smoke at home	0.9	1.0	1.5	-0.6	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	1.8	-1.0	-1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.5	1.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.9	-1.4	-0.6
Heart disease (mother)	0.9	1.0	1.3	1.2	0.9
Osteoporosis (self-reported)	0.9	1.1	1.5	-0.8	-1.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	0.4	1.4
Diastolic blood pressure, automated reading	0.9	2.7	4.1	-2.0	-1.1
Ulcerative Colitis (UC)	0.8	1.6	2.2	-1.0	-1.5
Breast Cancer	0.8	1.9	3.6	1.9	0.5
Smoking Status	0.8	1.8	1.9	-1.4	-1.3
Pulse rate	0.8	1.3	2.0	-0.8	-1.4
Peak expiratory flow (PEF)	0.8	2.0	3.1	0.9	1.8
Medication: Ibuprofen	0.8	0.9	1.2	-0.8	-1.1
Smoking status: Previous	0.8	1.3	2.5	0.0	1.6
Schizophrenia vs Biploar Disorder	0.7	1.0	1.7	0.5	1.3
Age at First Birth	0.7	1.0	1.2	0.9	1.1
Qualifications: None of the above	0.7	1.4	2.7	-0.4	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.0	1.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.2	-0.7	-1.1
Illnesses of mother	0.7	0.8	1.6	-0.2	-1.3
Glaucoma (self-reported)	0.7	0.9	1.6	1.3	0.3
Age at first live birth	0.7	1.3	2.5	-0.1	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.1	0.7	1.0
Chest pain or discomfort	0.7	1.1	2.1	1.5	-0.1
Financial situation satisfaction	0.7	0.9	1.7	0.2	-1.3
Medication: Bendroflumethiazide	0.7	1.1	1.4	0.9	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	0.9	-0.9	-0.9
Financial difficulties in last 2 years	0.6	0.8	1.5	-0.4	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.4	-0.6	1.6
Asthma	0.6	1.1	1.2	1.1	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.9	0.1	1.4
Wheeze or whistling in the chest in last year	0.6	1.2	2.3	1.5	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.3	-1.1	-0.1
Medication: Blood pressure	0.6	1.1	1.9	-0.5	-1.4
Whole body fat mass	0.6	2.7	3.3	1.8	1.4
Average weekly champagne plus white wine intake	0.6	0.8	1.4	-0.5	1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	0.3	1.2
Neuroticism (2016)	0.5	0.8	1.6	-0.1	-1.3
Hand grip strength (left)	0.5	1.2	2.3	-0.5	1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	-0.6	-0.9
Impedance of leg (right)	0.5	2.6	3.8	-1.9	1.2
Trunk fat percentage	0.5	2.0	2.6	1.6	1.2
Age when periods started (menarche)	0.5	1.3	2.6	0.2	1.6
Impedance of leg (left)	0.5	2.4	4.0	-2.0	0.9
Waist circumference	0.5	1.7	2.4	1.5	1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	0.9	-1.0	0.6
Fluid intelligence score	0.5	1.1	1.7	-0.7	1.3
Falls in the last year	0.5	0.7	1.3	1.2	-0.2
Noisy workplace	0.5	0.6	1.0	-0.3	-1.0
Medication: Lansoprazole	0.5	0.6	0.7	0.7	0.9
Arm fat mass (right)	0.5	1.9	3.0	1.7	0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	-0.5	-0.9
Medication: Seretide 50 evohaler	0.5	0.5	0.8	-0.9	-0.5
Had major operations	0.5	0.6	1.2	-1.1	-0.1
Friendships satisfaction	0.5	0.6	1.1	-0.1	1.1
Arm fat mass (left)	0.5	2.2	3.5	1.9	0.9
Myopia	0.5	0.7	1.2	0.5	-1.1
Reaction Time	0.4	0.8	0.9	-0.8	-1.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.3	-0.9	1.1
Fasting Glucose	0.4	0.5	0.6	-0.5	-0.8
Ulcerative Colitis	0.4	0.5	0.7	-0.6	-0.9
Lung FEV1/FVC ratio	0.4	1.9	3.3	-1.8	-0.7
Supplements: Zinc	0.4	0.5	0.8	0.9	0.4
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	0.9	0.4
Forced vital capacity (FVC)	0.4	1.6	2.4	-0.9	1.6
Medication: Ramipril	0.4	0.5	0.9	1.0	-0.3
Illnesses of siblings	0.4	0.6	1.1	0.4	-1.0
Hip circumference	0.4	1.9	3.0	1.7	0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.4	-0.3	1.5
Medication: Ventolin 100micrograms inhaler	0.4	0.6	0.8	-0.9	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.6	-0.8	0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	1.0	0.1
Suffer from ‘nerves’	0.4	0.6	0.7	-0.7	-0.9
Leg pain on walking	0.4	0.5	0.9	-0.4	0.9
Arm fat percentage (left)	0.4	1.6	3.2	1.8	-0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.6	0.8	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.5	-0.9
Pain experienced in last month	0.4	0.7	0.8	0.8	0.9
Supplements: Calcium	0.4	0.4	0.5	-0.7	-0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.3	0.9
Prostate Cancer	0.3	0.4	0.6	0.3	0.8
Blood Platelet Count	0.3	3.0	5.8	2.4	-0.4
Blood Red Count	0.3	2.5	3.8	2.0	1.1
Systolic Blood Pressure	0.3	1.4	2.8	-1.7	-0.2
Tanning	0.3	4.2	4.2	-2.0	-2.0
Medication: Co-codamol	0.3	0.3	0.4	0.4	0.6
Taking other prescription medications	0.3	0.4	0.6	0.5	0.8
Supplements: Glucosamine	0.3	0.3	0.6	-0.7	0.3
Body mass index (BMI)	0.3	1.2	2.0	1.4	-0.7
Nervous feelings	0.3	0.6	1.0	0.5	-1.0
Arm fat percentage (right)	0.3	1.3	2.1	1.4	-0.7
Pulse wave reflection index	0.3	0.4	0.5	0.5	-0.7
Blood clot in the leg (DVT)	0.3	0.5	0.7	-0.4	-0.9
High blood pressure (siblings)	0.3	0.5	0.8	0.5	0.9
Body fat percentage	0.3	1.1	1.8	1.4	0.6
Medication for pain relief, constipation, heartburn	0.3	0.6	1.2	-0.1	1.1
Medication: Allopurinol	0.3	0.4	0.6	-0.8	-0.4
Leg fat mass (right)	0.3	1.2	2.0	1.4	0.7
Number of full sisters	0.3	0.4	0.8	-0.1	-0.9
Knee pain experienced in last month	0.3	0.5	1.0	-1.0	-0.3
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.4	-0.8
Diabetes diagnosed by doctor	0.3	0.4	0.5	0.6	0.7
Asthma (self-reported)	0.3	0.7	0.8	0.9	0.7
Hearing aid user	0.3	0.4	0.8	-0.9	0.1
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.8	-0.4
Impedance of whole body	0.3	1.3	1.6	-1.0	1.3
Leg fat mass (left)	0.3	1.1	1.8	1.3	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.2	-0.2	1.1
Worry (Nagel 2018)	0.2	0.5	0.9	0.1	-0.9
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-0.5	-0.9
Ovarian Cancer	0.2	0.3	0.5	-0.7	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.7	0.0
Crohns Disease (2012)	0.2	0.3	0.4	-0.6	0.5
Mean Putamen Volume	0.2	0.3	0.5	0.1	0.7
HDL Cholesterol	0.2	0.3	0.3	-0.5	-0.5
LDL Cholesterol	0.2	0.3	0.4	0.7	0.4
BMI	0.2	1.3	2.1	0.7	-1.5
Lung FVC	0.2	1.2	2.2	-0.5	-1.5
Systolic blood pressure, automated reading	0.2	0.6	1.1	-1.0	0.4
Angina	0.2	0.3	0.6	0.8	-0.0
Pack years adult smoking proportion	0.2	0.2	0.2	0.5	-0.5
Maternal smoking around birth	0.2	0.3	0.3	-0.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	0.9	0.9	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.3	0.9
Stomach or abdominal pain in last month	0.2	0.3	0.3	0.5	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.4	-0.5
Past tobacco smoking	0.2	0.3	0.4	0.5	-0.7
Had menopause	0.2	0.2	0.3	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.7	0.6	0.9
Allergy	0.2	0.5	1.0	-0.2	-1.0
Pain all over the body in last month	0.2	0.2	0.3	0.5	-0.4
Medication: Simvastatin	0.2	0.3	0.5	0.4	0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	0.3	0.6	-0.5
Impedance of arm (left)	0.2	1.1	2.1	0.1	1.4
Length of working week for main job	0.2	0.2	0.3	0.5	-0.4
Tense / ‘highly strung’	0.2	0.3	0.4	0.4	-0.6
Birth weight	0.2	0.3	0.7	0.8	-0.0
Worry too long after embarrassment	0.2	0.4	0.8	0.9	0.1
Shortness of breath walking on level ground	0.2	0.2	0.3	0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	-0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	0.7	0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.7	0.4
Back pain experienced in last month	0.2	0.2	0.5	0.0	-0.7
Breast cancer (self-reported)	0.2	0.3	0.5	0.1	0.7
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	0.2	-0.9
Mother’s age at death	0.2	0.2	0.4	0.2	0.6
Medication: Blood pressure	0.2	0.4	0.6	0.5	0.8
Ever smoked	0.2	0.3	0.4	-0.7	0.3
Number of operations (self-reported)	0.2	0.3	0.7	-0.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.2	-0.7
Pack years of smoking	0.2	0.2	0.4	0.6	-0.3
Crohns Disease (2017)	0.1	0.2	0.2	-0.5	-0.3
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.1	-0.6
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.1	-0.5
Blood White Count	0.1	0.5	0.9	1.0	0.1
Heel T-Score	0.1	1.0	1.9	0.4	-1.4
Allergy or Eczema	0.1	0.3	0.4	-0.5	0.6
Cardiovascular Disease	0.1	0.2	0.3	0.6	-0.1
Chronotype (morning person)	0.1	0.2	0.4	0.6	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	-0.3
Diabetes (father)	0.1	0.1	0.2	0.3	0.4
Diabetes (mother)	0.1	0.1	0.2	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.3	0.0
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	-0.1
High blood pressure	0.1	0.1	0.2	0.3	-0.5
Medication: Atenolol	0.1	0.2	0.3	-0.2	-0.5
High blood pressure (mother)	0.1	0.1	0.1	-0.3	0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.6	-0.3
Had other major operations	0.1	0.1	0.2	0.1	-0.4
Mouth/teeth dental problems	0.1	0.2	0.5	-0.0	0.7
Heart attack	0.1	0.1	0.2	-0.1	0.5
Impedance of arm (right)	0.1	0.4	0.6	-0.3	0.8
Time employed in main current job	0.1	0.2	0.2	0.3	-0.4
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.3
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.4	0.1
Prospective memory result	0.1	0.1	0.1	0.4	0.2
Lung cancer (father)	0.1	0.1	0.2	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	-0.8	0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.4	0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.0	-1.0	0.2
Leg fat percentage (right)	0.1	0.3	0.6	0.8	-0.0
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.4	-0.1
Pulse wave peak to peak time	0.1	0.1	0.2	-0.3	0.5
Qualifications: College or University degree	0.1	0.3	0.5	-0.2	0.7
Angina (self-reported)	0.1	0.2	0.4	0.6	-0.1
Medication: Omeprazole	0.1	0.1	0.1	0.2	0.3
Mean time to correctly identify matches	0.1	0.1	0.2	-0.1	-0.4
Overall health rating	0.1	0.3	0.3	0.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.1	0.4
Medication for cholesterol	0.1	0.2	0.2	0.4	-0.4
Mineral and other dietary supplements	0.1	0.1	0.1	0.3	-0.3
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.5	0.1
Wears glasses or contact lenses	0.1	0.1	0.2	0.4	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	0.2
High cholesterol (Self-reported)	0.1	0.2	0.3	0.4	0.5
Medication: Lisinopril	0.1	0.2	0.3	-0.0	0.6
Medication: Atorvastatin	0.1	0.1	0.1	-0.3	-0.3
Leg fat percentage (left)	0.1	0.4	0.8	0.9	-0.1
Risk taking	0.1	0.1	0.2	-0.4	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	-0.2	0.6
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	-0.3	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.1	0.1	-0.3	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.3	0.0
Blood Eosinophil Count	0.0	0.2	0.4	-0.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.2	0.3
Hair Pigment	0.0	1.0	1.9	1.4	-0.3
Number of treatments/medications taken	0.0	0.0	0.0	0.0	-0.1
Average weekly spirits intake	0.0	0.0	0.0	0.0	0.2
Hearing difficulty/problems: Yes	0.0	0.1	0.1	0.2	-0.3
Diabetes (self-reported)	0.0	0.1	0.1	0.3	0.0
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.2	-0.2
Number of live births	0.0	0.0	0.0	-0.2	0.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.1	-0.3
Birth weight of first child	0.0	0.1	0.1	-0.4	0.0
Loud music exposure frequency	0.0	0.0	0.1	0.3	0.0
Comparative body size at age 10	0.0	0.1	0.2	-0.1	-0.4
Number of children fathered	0.0	0.0	0.1	-0.2	0.0
Family relationship satisfaction	0.0	0.0	0.0	-0.1	0.2
Hypertension (Self-reported)	0.0	0.1	0.2	0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	-0.0

Hub : Genes

STK16

Models

Trait associations