Hub : Genes

STON2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0830	0.0280	2.2e-04	0.015	0.019	0.020	0.023	0.025	5.1e-03	2.0e-03	1.5e-03	0.00071	4.7e-04
2	GTEx	Artery Tibial	0.1268	0.0555	7.2e-03	-0.001	NA	-0.002	NA	0.003	3.9e-01	NA	5.0e-01	NA	1.7e-01
3	GTEx	Prostate	0.5280	0.1160	5.0e-04	-0.006	NA	-0.007	NA	-0.002	4.9e-01	NA	5.2e-01	NA	3.6e-01
4	GTEx	Uterus	0.3400	0.1200	6.0e-03	0.014	NA	0.019	NA	0.014	1.7e-01	NA	1.4e-01	NA	1.7e-01
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.1525	0.0416	8.1e-14	0.070	0.124	0.143	NA	0.163	2.7e-08	7.8e-14	7.7e-16	NA	5.6e-18
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2550	0.0660	6.3e-11	0.166	0.159	0.153	NA	0.164	9.3e-10	2.2e-09	4.2e-09	NA	1.1e-09
7	TCGA	Brain Lower Grade Glioma	0.0862	0.0281	1.3e-08	0.058	0.069	0.064	NA	0.065	3.8e-07	2.8e-08	8.3e-08	NA	6.5e-08
8	TCGA	Pheochromocytoma and Paraganglioma	0.1510	0.0820	9.5e-03	0.043	0.063	0.019	NA	0.031	8.2e-03	1.6e-03	5.5e-02	NA	2.1e-02
9	TCGA	Prostate Adenocarcinoma	0.0382	0.0208	4.6e-03	0.011	0.015	0.022	NA	0.017	2.4e-02	8.3e-03	2.0e-03	NA	5.9e-03
10	TCGA	Thyroid Carcinoma	0.0660	0.0300	2.7e-03	0.040	0.020	0.013	NA	0.033	7.7e-05	4.6e-03	1.7e-02	NA	3.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.7	1.1	4.8	-0.7	-0.0	-0.5	-0.6	1.3	2.2	-0.0	-0.2	1.1	1.5
Bipolar Disorder or Schizophrenia	1.1	2.6	10.6	2.0	0.7	-1.3	0.7	0.7	1.9	3.3	1.5	1.7	0.4
Depressed Affect (Nagel 2018)	0.5	1.0	5.0	0.1	1.1	2.2	-0.2	-1.1	-0.9	-1.1	-0.3	-0.1	-0.6
Depression (Nagel 2018)	0.5	0.7	4.3	0.1	0.1	2.1	0.3	-0.1	-0.5	-0.6	-0.9	-0.9	0.9
Intelligence (Savage-Jansen 2018)	1.9	5.7	14.4	-3.1	-0.7	-2.6	-1.6	1.1	1.9	-2.3	-3.2	1.8	3.8
Neuroticism (Nagel 2018)	0.2	0.5	2.6	0.1	1.2	1.6	0.6	-0.2	-0.1	-0.3	0.3	-0.1	-0.9
Schizophrenia (2018)	1.8	3.8	17.4	3.1	1.0	-1.2	1.4	-0.1	0.7	4.2	2.1	1.2	-0.7
Schizophrenia vs Biploar Disorder	1.5	2.0	5.6	1.8	0.9	-0.9	2.3	-1.2	-1.1	2.4	0.8	0.6	-0.9
Worry (Nagel 2018)	0.1	0.3	1.2	-0.5	0.7	0.6	1.1	-0.1	0.3	-0.2	0.1	0.2	0.3
Alzheimer’s Disease (in mother)	2.6	3.0	8.2	-2.9	0.3	-1.8	-0.5	-0.8	-0.1	-2.9	-2.2	0.9	2.0
Alzheimer’s Disease (in father)	1.2	1.3	3.9	-1.5	1.3	-0.2	-0.4	-1.1	-0.3	-1.0	-2.0	1.1	1.1
Alzheimer’s Disease (including proxy)	2.3	3.4	8.6	-2.9	2.1	-1.7	-0.3	0.1	0.7	-1.7	-2.9	1.1	2.2
Crohns Disease (2017)	1.4	3.1	7.6	0.3	-1.8	2.5	-0.4	-1.1	-2.8	-2.2	-1.1	-2.4	0.3
Irritable Bowel Disease (IBD)	1.4	3.3	16.5	-0.3	-2.1	4.1	-0.5	-0.8	-1.9	-2.4	-0.5	-1.4	-0.1
Ulcerative Colitis (UC)	1.2	2.2	14.2	-0.9	-2.0	3.8	-0.4	-0.2	-0.1	-1.7	-0.2	0.2	-0.1
Major Depression (MDD)	0.5	0.6	1.5	0.9	-0.4	0.2	-0.1	-1.0	-1.1	0.8	0.8	0.1	-1.2
Reaction Time	2.0	3.8	10.3	1.4	-2.6	2.9	1.1	-0.6	-2.7	0.8	0.8	-3.2	-0.8
Verbal and Numeric Reasoning (VNR)	1.5	3.5	8.8	-1.5	-0.7	-1.8	-2.4	3.0	2.8	0.2	-1.4	0.4	2.2
Breast Cancer	0.6	1.4	3.3	1.0	1.8	-0.2	0.8	-1.8	-0.5	0.9	1.4	1.5	-0.7
Ovarian Cancer	0.3	0.4	1.3	0.0	1.1	-1.1	0.4	-0.5	-0.9	0.1	0.3	-0.1	-0.5
Prostate Cancer	0.5	0.8	3.0	-0.8	1.2	-0.1	0.0	1.2	1.7	0.1	0.7	0.7	0.1
Age at First Birth	1.1	1.6	6.7	-1.3	0.9	-2.0	-0.5	-0.1	0.5	-0.8	-0.9	1.1	2.6
Bipolar Disorder (2011)	0.7	0.7	5.8	0.4	-0.1	-0.5	-2.4	0.0	0.0	0.2	0.0	-0.9	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	3.6	0.1	0.3	0.7	1.9	0.1	0.2	0.3	-0.2	-0.0	0.7
Coronary Artery Disease (CAD)	0.5	0.7	3.3	0.1	-1.0	0.3	-1.8	-0.6	-1.0	-0.1	-0.5	-0.8	-0.1
Crohns Disease (2012)	1.1	1.8	5.6	-0.7	-1.9	1.8	0.7	1.0	-1.0	-1.6	-0.5	-2.4	-0.3
Mean Putamen Volume	1.1	1.3	5.3	-1.4	0.6	-2.3	-1.4	0.1	0.3	-1.0	-0.9	0.1	1.0
Fasting Glucose	0.5	0.7	3.8	0.3	-0.9	0.6	1.9	0.4	-0.0	-0.1	0.4	-1.0	-0.4
HbA1C	0.5	0.5	2.0	-0.3	1.2	0.1	1.4	-1.0	-0.1	-0.5	-0.2	0.4	-0.4
HDL Cholesterol	1.9	3.2	8.9	2.7	-0.1	2.8	0.2	-0.4	-0.7	1.8	3.0	-0.2	-2.2
LDL Cholesterol	0.3	0.5	1.9	0.1	-1.4	0.7	-0.4	-0.3	-0.3	1.0	1.0	0.3	-0.6
Lupus	1.2	1.8	4.9	-1.1	-0.8	0.5	1.0	-1.4	-2.2	-1.4	-1.8	-1.2	1.2
Neuroticism (2016)	0.9	1.3	6.2	0.8	0.3	2.5	0.1	0.8	1.1	-0.0	1.2	-0.3	-1.8
Primary Biliary Cirrhosis	0.3	0.5	1.0	0.5	-1.0	1.0	0.8	0.6	0.1	0.5	0.5	-0.6	-0.7
Rheumatoid Arthritis	1.6	2.2	5.5	2.1	-1.1	2.1	0.4	-0.2	-1.7	1.0	0.2	-2.3	-1.3
Schizophrenia (2014)	2.2	4.8	23.0	3.1	0.4	-1.6	1.8	0.4	1.4	4.8	2.2	1.6	-0.4
Triglycerides	0.1	0.1	0.4	-0.6	-0.5	-0.4	0.1	-0.4	0.0	-0.2	-0.2	0.4	0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.7	0.6	0.2	0.8	-1.9	-0.5	-0.2	0.4	1.5	-0.3	-1.5
Ulcerative Colitis	1.0	1.4	6.9	-1.0	-1.9	2.6	0.4	0.2	-0.6	-1.3	-0.0	-0.7	-0.3
Blood Eosinophil Count	0.7	5.2	15.4	2.7	2.6	0.5	1.3	-0.5	0.4	3.9	3.2	1.9	-2.6
Blood Platelet Count	2.0	23.1	127.7	0.3	4.4	-1.1	0.4	-11.3	-7.8	-0.5	1.6	3.9	-1.8
Blood Red Count	0.6	6.1	14.4	2.8	-2.5	-1.0	1.3	3.5	0.9	3.8	1.5	-3.8	-0.6
Blood White Count	1.1	7.8	29.4	3.5	2.9	-1.0	1.4	-0.9	-0.0	5.4	3.6	1.4	-3.0
Heel T-Score	0.5	3.6	11.6	-2.0	-1.6	1.4	-2.7	0.5	-1.0	-3.4	-1.6	-2.2	0.5
BMI	0.3	1.8	7.0	-2.0	0.7	-0.2	-0.1	-0.8	0.5	-2.0	1.0	2.7	0.1
Height	0.1	2.5	8.0	1.3	2.1	-1.1	-0.1	-2.3	-0.3	1.6	1.0	2.8	-0.6
Waist Hip Ratio (WHR)	0.1	0.6	2.4	0.4	-0.8	1.6	-1.3	-0.2	-0.6	-0.2	-0.5	-0.6	0.2
Systolic Blood Pressure	0.4	1.8	3.6	-0.5	1.6	-1.1	-1.2	1.9	1.7	-1.0	-1.9	-0.2	1.4
Smoking Status	0.3	0.7	1.9	-0.1	1.4	-0.0	-1.2	0.2	-0.2	-1.2	-1.0	-0.8	0.4
Allergy or Eczema	1.6	4.3	19.3	-3.3	-1.5	-0.2	0.9	-1.9	-1.4	-4.4	-0.8	0.8	1.6
Cardiovascular Disease	0.4	1.4	3.6	-1.6	-0.4	-1.5	-0.2	-0.8	-0.1	-1.9	-0.9	1.3	1.4
Hypothyroidism (self reported)	2.1	4.9	13.0	-1.1	-1.9	3.2	1.8	-3.6	-2.5	-3.0	-0.7	1.4	0.2
Respiratory disease	0.5	1.0	1.9	-1.2	1.4	-0.9	0.2	-0.6	0.6	-1.1	-1.2	1.2	1.1
Type 2 Diabetes (T2D) (2018)	1.6	3.0	8.9	-3.0	1.1	-1.2	-0.5	-0.3	1.1	-1.6	-1.8	2.4	2.4
Lung FEV1/FVC ratio	0.2	0.9	3.2	-0.7	-0.2	-0.3	-1.1	-1.5	-0.9	-1.8	0.3	1.0	-0.2
Lung FVC	1.6	8.1	24.4	-3.1	-0.5	-0.4	-2.9	-0.5	-0.9	-4.1	-4.9	-0.8	4.4
Neuroticism	0.2	0.6	1.4	0.3	1.0	1.2	1.1	0.2	0.6	-0.1	1.0	0.1	-0.7
Chronotype (morning person)	1.3	3.0	9.7	2.5	0.8	0.8	0.2	-0.4	0.0	2.6	3.1	0.4	-2.4
Hair Pigment	0.1	3.8	10.8	1.5	2.6	-1.2	1.1	0.1	2.1	3.0	1.2	3.3	-0.8
Tanning	0.1	1.8	5.6	-1.6	0.1	0.9	0.7	1.3	0.3	-2.4	-1.9	-1.6	0.7
Hand grip strength (left)	0.2	0.4	1.7	0.2	1.3	-0.3	-1.0	-0.4	-0.1	-0.9	0.4	0.4	0.0
Number of treatments/medications taken	1.3	2.3	7.2	-1.9	-0.3	0.5	1.7	-1.1	0.4	-1.5	-0.8	2.2	2.7
Average weekly spirits intake	0.9	1.1	5.9	-0.6	0.5	-1.1	2.4	0.4	0.7	0.9	0.4	1.0	1.0
Sensitivity / hurt feelings	0.2	0.4	1.3	-0.3	0.8	-0.8	1.1	-0.0	-0.2	-0.4	0.7	-0.3	-0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.5	-0.1	0.8	1.9	0.0	-1.0	-0.3	-1.1	-0.7	0.1	0.6
Hearing difficulty/problems: Yes	1.3	1.9	9.9	-0.7	2.1	-0.4	-1.2	-0.5	1.5	0.1	0.5	3.1	-0.3
Relative age of first facial hair	0.2	0.4	1.5	0.3	1.1	0.3	-0.2	-0.2	0.6	1.0	-0.2	1.2	0.2
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	9.4	-2.3	0.3	1.0	-0.9	-0.6	1.3	-1.8	0.4	3.1	1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	1.5	-0.4	1.9	1.1	-0.9	-1.1	0.8	1.1	-1.0	-1.6
Ever had hysterectomy (womb removed)	1.3	1.4	7.7	1.4	0.2	-0.3	0.6	0.4	1.0	2.8	1.2	1.0	-0.6
Systolic blood pressure, automated reading	0.3	0.8	1.8	-0.7	1.3	-1.2	0.8	-0.3	0.3	-0.6	-1.2	0.8	0.7
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	5.6	0.4	-1.1	2.4	1.7	0.5	-0.4	0.8	-0.6	-1.6	0.8
Angina	0.9	1.2	3.7	0.9	-1.3	0.3	1.9	-1.3	-1.4	1.2	0.6	0.0	-0.8
Medication for hormone replacement therapy	2.9	3.2	10.1	2.1	-0.2	2.1	0.6	-0.9	-0.4	2.0	2.8	-0.1	-3.2
Vitamin and mineral supplements	0.7	0.9	2.5	1.1	0.6	-0.2	-0.4	1.4	0.7	1.6	-0.4	-1.3	-0.6
Supplements: Zinc	1.0	1.0	3.7	-0.8	-0.8	0.2	-0.1	-1.2	-0.9	-1.1	-0.7	1.2	1.9
Medication: Co-codamol	2.0	2.3	7.1	-2.1	-0.5	-1.3	-1.4	1.3	0.5	-1.3	-2.7	-1.3	1.5
Medication: Metformin	1.6	2.2	6.3	-2.5	0.8	-0.8	0.5	1.2	1.3	-0.6	-2.2	0.6	2.4
Diabetes (father)	0.2	0.3	1.2	-0.4	-0.0	1.1	-0.2	0.0	-0.4	0.5	-0.5	-0.5	0.7
Diabetes (mother)	0.5	0.6	2.6	0.3	-1.4	-1.6	0.9	-0.6	-0.2	0.6	0.2	0.3	-0.4
Severe depression (siblings)	0.3	0.3	0.9	-0.4	0.5	0.4	0.4	-0.8	-0.5	0.0	0.4	1.0	0.4
Pack years adult smoking proportion	1.2	1.9	5.2	-2.3	-0.7	-0.5	-1.2	0.3	-0.6	-1.5	-1.8	-1.6	1.8
Impedance of leg (right)	0.9	4.3	11.1	2.5	-1.4	-1.7	3.3	1.4	-0.2	3.2	0.8	-2.9	-0.1
Leg fat-free mass (left)	0.5	2.7	10.8	-1.8	1.4	0.3	-2.0	-0.4	1.5	-1.9	0.2	3.3	0.2
Trunk fat percentage	0.2	0.9	4.1	0.2	0.4	-0.7	0.5	-0.1	0.7	0.8	1.5	2.0	-0.4
Hand grip strength (right)	0.4	1.0	3.0	-0.8	1.3	-1.2	-1.2	-0.2	-0.0	-1.7	-0.7	0.5	1.2
Townsend deprivation index at recruitment	0.5	0.7	1.5	0.6	-1.2	0.6	0.3	-0.6	-1.0	0.3	0.9	-1.2	-0.8
Current tobacco smoking	0.7	1.1	3.3	-1.0	-1.0	0.2	-0.5	1.5	0.4	-1.7	-0.7	-1.8	0.5
Average weekly fortified wine intake	1.8	2.1	4.3	-1.3	-1.4	-0.9	2.1	2.0	1.2	-0.9	-0.9	-0.9	2.1
Maternal smoking around birth	0.5	0.7	1.6	0.5	-0.7	1.0	0.9	1.0	1.0	0.4	1.3	-0.3	-0.6
Fed-up feelings	0.7	1.2	5.0	1.2	1.1	2.2	1.1	-0.6	-0.6	0.7	0.6	-0.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	5.8	0.5	-0.3	2.4	-0.4	-0.5	-1.1	-0.7	-0.1	-1.3	-0.2
Relative age voice broke	0.6	0.9	3.3	-0.8	0.9	-0.5	-1.3	-0.1	0.4	-0.5	-1.8	0.5	1.2
Taking other prescription medications	2.1	3.2	10.0	-3.2	-0.6	-0.6	0.8	-0.1	1.2	-2.2	-1.2	1.9	3.0
Age when periods started (menarche)	0.1	0.3	0.7	0.8	-0.6	-0.7	0.5	-0.4	-0.6	0.1	-0.2	-0.6	-0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.5	-0.4	0.4	-0.1	-0.1	0.4	0.4	-0.3	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	-0.8	-0.5	0.5	-0.4	-0.6	-1.4	-1.4	-0.9	-1.2	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.4	-0.5	-0.1	0.1	0.5	-1.2	-0.7	-0.1	0.1	0.6	0.5
Qualifications: CSEs or equivalent	0.2	0.2	0.7	0.9	-0.7	-0.5	0.4	0.0	0.0	0.4	0.4	-0.3	-0.2
Serious illness, injury or assault to yourself	1.7	2.0	6.5	2.5	-0.3	-0.5	1.6	-0.3	-0.0	2.1	2.4	0.4	-0.5
High blood pressure	0.3	0.9	2.7	-1.7	-0.3	-0.6	0.8	-0.2	0.4	-1.2	-0.7	1.1	1.3
Hayfever, allergic rhinitis or eczema	1.7	3.6	17.0	-3.1	-1.1	0.2	-0.7	-1.5	-1.0	-4.1	-1.1	0.8	1.6
Multivitamins +/- minerals	1.7	2.2	8.5	-2.4	-0.5	-0.6	0.1	-1.6	-0.9	-2.9	-0.7	1.2	1.3
Stomach or abdominal pain in last month	1.9	2.4	10.6	1.6	1.0	-1.2	3.3	-1.1	-0.3	1.8	1.3	1.4	0.1
Supplements: Glucosamine	2.1	2.7	9.4	-2.0	1.1	-2.5	-0.3	0.2	0.0	-1.7	-3.1	0.1	1.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.0	-1.0	1.7	-0.2	-1.4	1.4	1.7	0.1	-0.4	0.7	0.6
Medication: Atenolol	1.0	1.3	3.8	1.0	-1.3	1.4	1.9	0.5	-0.4	0.7	1.2	-1.2	-0.9
Medication: Levothyroxine sodium	2.5	4.2	11.0	-1.5	-1.0	1.5	3.3	-3.1	-1.9	-2.5	-1.0	1.8	1.4
Sitting height	0.1	0.9	5.2	0.9	-2.3	-0.2	0.0	1.0	0.3	0.0	0.9	-0.9	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-0.9	-0.6	0.3	-0.1	-1.3	-1.1	-0.8	-0.5	0.5	0.4
High blood pressure (mother)	0.9	1.2	3.5	1.7	-0.1	1.4	-0.7	-0.4	-0.9	1.0	0.8	-0.8	-1.9
Body mass index (BMI)	0.3	1.5	6.0	-1.6	1.0	0.5	-0.6	-0.8	0.4	-1.7	0.8	2.4	-0.1
Impedance of leg (left)	1.1	5.2	14.0	2.9	-1.2	-2.0	3.6	0.9	-0.5	3.7	1.6	-2.6	-0.6
Leg predicted mass (left)	0.5	2.7	10.9	-1.9	1.5	0.3	-2.0	-0.3	1.5	-1.9	0.2	3.3	0.2
Trunk fat mass	0.2	1.0	6.5	-0.3	0.6	-0.5	-0.0	-0.4	0.8	0.0	1.4	2.5	-0.4
Waist circumference	0.2	0.7	4.2	-0.6	0.8	0.4	-0.0	-0.5	0.6	-0.9	0.8	2.1	-0.1
Number of incorrect matches in round	3.7	6.1	11.8	2.8	-0.4	1.9	2.6	-3.4	-2.1	2.8	3.2	1.7	-2.2
Past tobacco smoking	0.5	0.9	6.1	-0.4	-2.5	-0.9	0.7	1.0	0.5	0.3	-0.2	-0.7	0.1
Alcohol usually taken with meals	0.6	1.0	2.7	-0.9	-1.1	0.3	-1.6	0.1	-0.0	-0.7	-1.6	0.1	1.6
Nervous feelings	0.7	1.4	3.9	1.1	0.6	1.5	1.4	0.6	0.6	1.5	2.0	0.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.4	1.1	-0.7	1.6	1.8	0.3	-0.2	0.4	0.8	-1.2	-0.8
Hearing difficulty/problems with background noise	0.7	1.1	3.1	-0.7	0.2	1.0	0.2	-1.7	-0.5	-1.1	0.8	1.8	-1.3
Hair/balding pattern: Pattern 2	0.2	0.3	1.1	0.5	0.6	0.1	-0.1	-0.9	-1.0	0.1	0.1	-0.3	-0.4
Had menopause	0.5	0.6	3.5	-0.1	-0.6	-0.2	1.9	-0.1	-0.9	-0.1	0.2	-0.9	-0.5
Had other major operations	0.4	0.5	1.4	-0.7	0.3	-1.2	-0.3	-0.7	0.0	-0.5	-0.1	1.2	1.0
Forced vital capacity (FVC)	0.4	1.7	5.6	-1.1	-0.6	-0.7	-2.3	-0.1	0.4	-0.9	-1.5	0.7	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	1.3	-0.0	0.2	-0.3	-0.8	-0.3	-1.0	-0.6	0.1	-1.1	-0.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.4	1.5	0.5	0.7	-1.3	-1.1	-1.1	1.0	1.0	-0.1	-1.8
Qualifications: None of the above	2.1	4.5	9.5	1.7	1.9	-0.4	2.6	-3.1	-2.9	0.1	2.4	-0.7	-2.7
Financial difficulties in last 2 years	1.1	1.4	5.8	-1.1	0.6	-0.2	1.2	-1.6	0.1	-0.8	-0.4	2.4	1.4
Mouth/teeth dental problems	0.3	0.5	1.7	0.1	0.2	-1.0	-1.3	0.5	0.8	0.2	-0.7	0.5	1.0
Heart attack	0.5	0.6	1.9	0.0	-0.8	1.4	1.2	-0.1	-0.6	-0.4	0.7	-0.5	-1.0
Allergy	1.3	3.0	13.3	2.9	0.6	0.6	0.5	0.9	0.6	3.6	1.7	-0.4	-1.7
Pain all over the body in last month	0.8	0.9	4.2	1.2	0.3	-0.0	2.1	-1.1	-0.5	0.5	0.6	1.0	-0.6
Diabetes (self-reported)	0.8	1.2	3.8	-1.9	-0.1	0.2	0.6	-0.1	0.4	-1.3	-1.4	0.8	1.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	8.4	-1.8	-0.5	0.5	-1.1	-1.5	-1.8	-2.9	-0.8	-0.7	0.9
Medication: Ramipril	0.5	0.6	1.9	-0.6	-0.6	0.3	-1.1	1.4	0.9	-0.8	-0.6	-0.5	0.4
Medication: Simvastatin	0.5	0.7	2.1	-0.5	-0.3	-0.3	0.8	-1.4	-0.5	-1.0	-0.5	1.4	0.4
Fluid intelligence score	2.3	4.8	8.1	-2.8	-0.7	-2.5	-2.2	2.4	2.7	-0.7	-2.4	1.1	2.7
Illnesses of siblings	1.4	2.0	6.2	-0.3	-0.2	-0.5	-2.5	2.2	1.6	-0.1	-1.5	-1.8	0.5
Neuroticism score	0.3	0.7	1.9	0.3	1.0	1.4	0.9	-0.4	0.0	-0.1	1.1	0.2	-1.3
Weight	0.3	1.7	9.2	-1.0	1.2	0.1	-0.7	-1.0	0.7	-1.1	1.4	3.0	-0.6
Impedance of arm (right)	0.4	1.8	7.7	1.5	-0.8	-1.4	1.4	1.4	0.8	2.8	0.4	-1.0	0.2
Arm fat percentage (right)	0.3	1.3	8.3	-0.7	1.0	-0.1	-0.1	-0.3	1.1	-0.2	1.4	2.9	-0.4
Trunk fat-free mass	0.4	2.0	8.7	-1.0	1.8	0.4	-0.9	-1.2	0.8	-1.6	1.0	3.0	-0.8
Hip circumference	0.3	1.2	6.4	-0.8	1.5	0.3	-0.3	-0.4	1.0	-0.5	1.2	2.5	-0.3
Time employed in main current job	1.1	1.2	3.4	0.8	-0.6	0.7	0.2	1.4	0.8	1.8	1.9	-0.1	-1.2
Alcohol intake versus 10 years previously	0.6	0.9	3.9	1.7	-0.8	0.2	0.5	-0.4	-0.4	2.0	0.7	-0.4	-0.7
Father’s age at death	0.9	1.2	4.5	-1.7	-0.3	-0.5	-0.3	-0.6	-0.8	-1.3	-2.1	-0.3	1.3
Worrier / anxious feelings	0.2	0.4	1.1	-0.7	-0.4	0.6	0.6	0.7	0.2	-0.3	-0.8	-1.0	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	5.8	-0.3	-1.1	0.6	2.4	-1.2	-1.0	-1.0	0.7	-0.1	-0.1
Falls in the last year	0.7	1.0	2.9	-0.3	1.6	1.1	0.5	-1.7	-1.1	-0.6	0.4	1.1	-0.5
Hair/balding pattern: Pattern 3	0.9	1.3	4.7	-0.2	1.3	-0.1	1.3	1.4	2.2	0.8	0.9	1.1	-0.5
Number of live births	0.6	0.8	5.5	0.5	0.9	-0.1	2.3	0.2	0.5	0.9	0.3	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	5.4	-0.9	-0.9	-0.6	-2.3	-0.3	-0.1	-1.1	-1.1	0.3	1.9
Pulse rate	1.0	1.6	4.7	-1.6	-0.4	1.0	0.7	-1.2	-1.1	-2.2	-1.7	-0.3	1.4
Happiness	0.9	1.1	4.5	-0.1	-0.1	2.1	0.3	-0.5	-0.8	-1.9	-0.1	-1.0	-1.0
Noisy workplace	1.4	1.8	7.5	1.8	-0.8	2.7	0.6	0.9	0.1	0.8	0.4	-1.8	-1.0
Qualifications: A levels/AS levels or equivalent	2.2	4.9	13.9	-2.6	-0.1	-2.0	-2.7	1.2	1.5	-2.0	-3.0	0.4	3.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.9	-1.4	-0.4	-0.4	-1.0	0.1	-0.0	-0.8	-1.5	0.2	1.7
Mouth/teeth dental problems: Dentures	0.7	1.2	4.2	0.7	-0.8	0.7	2.0	-0.7	-1.7	0.5	0.2	-1.6	-0.4
Asthma	0.1	0.2	0.9	-0.6	-0.2	-1.0	0.1	0.3	0.1	-0.3	-0.8	-0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	1.0	2.1	-1.0	-0.2	1.0	-0.6	-0.9	-1.2	-1.5	-0.8	-0.6	1.3
Medication: Cholesterol lowering	0.3	0.4	1.4	0.1	-0.2	0.7	1.2	-0.7	-0.9	-0.7	-0.5	-0.4	-0.3
Depression (self-reported)	1.4	1.7	3.9	-1.8	-0.5	0.3	-0.5	0.3	1.3	-2.0	-1.4	1.2	2.0
Medication: Lansoprazole	1.2	1.3	6.1	0.3	1.2	-0.3	1.3	-0.7	0.6	1.1	1.3	2.5	0.0
Prospective memory result	1.7	2.0	8.1	0.8	-0.7	0.8	1.5	-2.8	-2.4	-0.3	1.5	0.2	0.5
Lung cancer (father)	2.2	2.5	5.6	1.6	-0.3	0.5	2.4	-2.0	-2.0	1.7	1.8	-0.0	-1.8
Illnesses of mother	0.9	1.1	3.0	-0.2	0.9	-0.6	1.1	1.1	1.7	0.8	-0.5	1.3	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	4.0	-0.8	-0.9	-1.0	-2.0	-0.9	-0.3	-0.9	-0.4	0.9	1.5
Pulse wave Arterial Stiffness index	1.4	1.6	3.8	-1.1	2.0	0.8	0.5	-1.4	-0.8	-1.4	-1.5	1.0	1.5
Impedance of arm (left)	0.4	2.1	8.1	1.7	-0.8	-1.5	1.8	1.3	0.6	2.8	0.3	-1.1	0.5
Arm fat mass (right)	0.4	1.6	9.7	-1.0	1.1	-0.0	-0.3	-0.5	1.1	-0.8	1.4	3.1	-0.3
Trunk predicted mass	0.3	2.0	8.5	-1.0	1.8	0.5	-1.0	-1.1	0.8	-1.6	1.0	2.9	-0.9
Standing height	0.1	1.1	3.0	1.1	0.5	-1.0	0.2	-0.8	0.5	1.1	1.6	1.7	-0.9
Length of working week for main job	0.2	0.2	0.9	0.2	0.6	-0.1	-0.9	0.0	0.0	0.8	0.3	0.1	-0.3
Exposure to tobacco smoke at home	1.2	1.4	4.8	1.2	0.3	0.3	0.1	2.2	1.0	0.7	1.6	-1.3	-1.1
Breastfed as a baby	1.0	1.3	4.2	0.0	-1.7	-0.4	-1.4	0.1	-1.4	-0.9	-0.3	-2.1	-0.5
Tense / ‘highly strung’	0.4	0.7	2.9	0.0	-0.3	0.2	0.4	-1.6	-1.7	-0.6	-0.5	-0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	11.0	1.7	-1.3	3.3	-1.0	-0.2	-0.5	0.9	1.2	-1.2	-1.2
Hair/balding pattern: Pattern 4	1.9	4.7	13.6	-2.8	-0.4	-0.1	-2.7	0.5	0.0	-3.7	-3.2	-0.7	2.6
Birth weight of first child	1.4	2.6	5.7	2.1	0.1	0.6	2.2	-2.0	-1.9	2.4	1.4	0.5	-1.1
Peak expiratory flow (PEF)	0.6	1.5	6.2	-1.3	-0.3	-0.8	-2.5	0.3	0.2	-1.8	-1.0	-0.2	1.3
Pulse wave reflection index	1.2	1.4	5.3	0.7	2.3	0.3	1.5	-0.7	0.4	1.4	0.2	1.9	0.3
Ever highly irritable/argumentative for 2 days	1.4	1.6	7.7	1.4	-0.1	2.8	0.5	0.1	0.2	0.9	1.6	-0.5	-1.6
Loud music exposure frequency	1.8	1.9	8.2	2.5	0.6	-0.0	0.3	0.3	0.2	2.9	1.7	-0.0	-1.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.5	-0.2	-0.7	0.1	-1.6	1.3	1.6	0.6	-1.0	0.8	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.9	-0.3	0.2	1.2	0.9	-1.1	-1.0	-0.6	-1.4	-0.2	-0.1
Blood clot in the leg (DVT)	0.7	1.0	3.7	-0.5	1.6	0.4	1.0	-1.1	0.4	-0.6	0.4	1.9	0.1
Medication: Paracetamol	0.9	1.5	4.7	-0.6	-1.3	0.0	2.2	-1.2	-0.8	-0.2	-1.4	0.9	1.9
Headache pain in last month	1.1	1.9	9.9	1.4	-1.2	0.2	3.1	0.5	0.3	1.8	1.4	-0.1	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.7	-0.1	-0.5	-0.8	0.7	0.6	-0.1	-0.3	-0.3	0.3
Glaucoma (self-reported)	0.7	0.8	3.0	1.0	-0.3	0.5	-0.8	-1.2	-0.0	1.0	0.7	1.7	-0.5
Gout (self-reported)	1.3	1.8	6.7	-1.1	0.1	-0.1	2.6	1.0	1.9	-0.6	1.9	1.3	0.3
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	12.7	-1.6	-0.9	2.5	2.5	-3.6	-2.1	-2.6	-1.0	2.0	1.1
Medication: Amlodipine	0.7	1.0	3.4	0.4	-0.3	-1.0	-1.1	-1.8	-0.7	0.5	0.6	1.8	-0.1
Medication: Ventolin 100micrograms inhaler	2.1	2.7	8.8	1.7	0.1	2.2	1.8	-0.0	-1.0	1.2	1.3	-1.6	-3.0
Birth weight	1.4	3.0	6.7	2.3	1.1	2.1	1.4	-1.7	-1.1	1.2	2.1	0.7	-2.6
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.8	-0.7	0.2	1.2	-0.1	-2.2	-1.2	-0.6	0.2	1.0	0.8
High blood pressure (siblings)	1.2	1.7	5.0	1.0	-0.2	0.4	1.8	-2.2	-2.2	0.4	1.3	0.7	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.5	4.6	-0.9	-0.2	-1.4	-2.1	-0.4	0.4	-0.6	-1.0	1.0	2.2
Body fat percentage	0.2	0.8	4.2	-0.1	0.5	-0.6	0.7	-0.1	0.8	0.4	1.3	2.0	-0.3
Leg fat percentage (right)	0.2	0.7	3.2	-0.5	0.8	-0.4	1.1	-0.0	0.8	-0.0	1.2	1.8	-0.0
Arm fat-free mass (right)	0.3	1.5	6.7	-1.2	1.0	0.3	-0.9	-1.1	0.5	-1.8	0.8	2.6	-0.3
Exposure to tobacco smoke outside home	0.6	0.8	2.3	0.3	0.8	1.5	1.5	-1.0	-0.6	-0.4	0.7	0.5	-0.8
Comparative body size at age 10	0.1	0.2	1.9	-0.6	0.0	-0.2	-1.4	0.2	0.0	-0.2	0.1	0.1	-0.1
Number of full brothers	0.5	0.6	1.7	1.1	-0.3	-0.8	0.4	0.4	-0.4	0.7	1.1	-1.3	-0.1
Worry too long after embarrassment	1.2	2.0	6.1	1.3	1.4	1.6	1.6	-0.7	-0.9	1.3	1.2	-0.5	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.7	0.8	0.5	1.4	0.4	-1.3	-0.0	0.3	1.6	1.2	0.2
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	-0.5	1.1	0.3	0.4	-0.7	-0.6	-0.4	-0.2	-0.1	-0.4
Number of children fathered	1.5	1.6	6.8	-0.8	0.6	-2.6	-1.3	-2.0	-1.3	-0.1	-0.5	0.9	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.4	-0.3	1.0	-1.0	1.0	1.1	0.5	0.7	0.0	-1.2
Age at first live birth	1.0	1.8	4.9	-0.6	-1.9	-0.3	-0.9	1.7	0.3	-0.9	-2.2	-1.8	1.1
Pulse wave peak to peak time	1.3	1.6	3.8	1.1	-1.9	-0.9	-0.6	1.3	0.8	1.3	1.7	-0.9	-1.5
Health satisfaction	0.9	1.2	3.3	-1.2	1.8	0.1	1.7	-0.7	-0.3	-1.8	-0.0	0.3	0.3
Shortness of breath walking on level ground	0.2	0.2	1.1	-0.4	0.3	0.2	0.4	-1.0	-0.7	-0.0	0.3	0.1	0.3
Qualifications: College or University degree	1.4	4.4	11.2	-2.5	-0.0	-0.6	-3.3	3.3	3.0	-0.9	-1.9	-0.3	1.5
Eye problems/disorders: None of the above	1.5	1.8	6.7	-0.5	-1.3	0.3	0.4	-0.5	-1.6	-2.6	-1.4	-2.0	0.3
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.9	0.8	-0.4	0.4	-0.1	-0.5	0.6	1.4	1.7	1.3	-0.8
Emphysema/chronic bronchitis	0.9	1.1	3.0	0.3	0.6	-0.7	1.6	-1.7	-1.6	-0.1	-0.8	0.2	0.9
Medication for pain relief, constipation, heartburn	1.6	2.7	5.6	0.8	1.5	-0.8	-2.4	2.3	2.1	1.3	1.2	-0.4	-2.2
Neck or shoulder pain in last month	1.2	1.8	6.0	0.5	-0.8	1.8	2.5	-1.5	-0.9	-0.1	1.9	0.9	-0.2
Medication: Blood pressure	0.1	0.1	0.5	-0.1	0.2	0.4	0.3	0.3	0.3	-0.7	0.1	-0.0	-0.3
Angina (self-reported)	1.0	1.4	3.6	0.8	-1.7	0.4	1.9	-1.1	-1.7	1.1	0.3	-0.7	-0.7
Migraine (self-reported)	1.7	2.1	7.1	1.9	0.6	0.3	2.7	-1.7	-1.7	1.4	1.6	0.2	-0.1
Medication: Ibuprofen	0.7	0.9	2.7	-1.1	0.3	0.8	-0.4	-0.5	-0.6	-1.5	-0.8	-0.3	1.6
Medication: Allopurinol	1.0	1.3	4.5	-1.1	0.3	0.2	2.1	1.8	1.4	-0.3	0.3	-0.7	0.9
Medication: Omeprazole	0.7	0.9	1.9	1.1	1.4	0.2	0.9	-1.2	-0.9	1.3	0.3	0.6	-0.3
Medication: Seretide 50 evohaler	1.7	1.9	5.6	-1.2	-1.2	-0.7	-1.4	2.4	0.6	-0.9	-1.5	-2.2	0.3
Mean time to correctly identify matches	1.4	2.7	7.9	0.7	-2.2	2.0	1.2	-1.1	-2.8	0.2	0.2	-2.6	-0.5
Heart disease (mother)	1.4	1.7	7.4	1.2	-1.7	2.7	-1.0	-0.4	-1.1	0.2	0.4	-1.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.3	0.6	0.2	1.3	1.2	0.4	-0.6	0.6	-0.5	-1.5	-0.9
Whole body fat mass	0.2	1.0	6.5	-0.9	0.7	-0.4	0.1	-0.4	0.8	-0.7	0.9	2.6	-0.0
Leg fat mass (right)	0.3	1.2	5.5	-1.4	0.8	-0.5	0.0	0.1	1.2	-1.0	0.8	2.3	0.4
Arm predicted mass (right)	0.3	1.3	5.8	-1.0	1.0	0.4	-0.8	-1.0	0.5	-1.6	0.8	2.4	-0.5
Pulse rate, automated reading	0.5	1.6	6.1	-1.3	0.3	0.1	0.0	0.8	1.0	-1.5	-2.0	0.3	2.5
Alcohol intake frequency.	1.1	2.5	9.9	1.2	-1.7	0.3	1.5	-2.4	-3.2	0.0	0.3	-1.6	-0.4
Comparative height size at age 10	0.7	3.8	9.9	1.9	1.5	-1.3	1.8	-1.3	0.4	2.6	3.2	2.6	-1.2
Number of full sisters	0.6	0.8	1.6	0.7	-1.3	-0.1	1.1	-1.1	-1.2	1.2	0.5	-0.4	-0.4
Suffer from ‘nerves’	0.3	0.5	2.3	-0.5	1.0	0.4	1.5	-0.5	0.2	0.3	0.3	0.8	0.6
Overall health rating	0.8	1.7	4.0	0.2	-1.3	2.0	1.4	-1.8	-2.0	-0.9	0.7	-0.4	-1.0
Chest pain or discomfort	1.4	2.0	5.8	-0.5	-1.1	1.5	2.0	-1.6	-2.4	-1.4	-0.6	-1.2	-0.2
Had major operations	1.3	1.6	6.2	-0.4	-1.1	-0.7	0.8	2.5	0.8	-0.1	-1.4	-2.0	0.5
Age at last live birth	0.6	0.8	4.6	-0.1	-0.8	-0.1	0.3	0.5	-0.3	-0.3	-2.1	-1.0	1.2
Family relationship satisfaction	0.8	1.0	2.3	0.8	-0.6	0.9	0.3	-1.2	-1.5	-0.5	1.3	-0.7	-1.4
Leg pain on walking	1.6	2.0	6.5	1.6	-0.1	2.5	0.3	-1.8	-1.7	0.1	1.2	0.0	-2.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.6	0.7	-1.4	1.1	1.7	-1.6	-1.9	0.1	0.8	-0.7	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.5	-0.0	0.2	0.1	-0.2	-1.2	-1.0	-0.1	-0.1	0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.6	-0.7	-0.9	0.3	-1.6	0.4	-0.1	-0.8	-1.2	-0.8	-0.4
Medication: Aspirin	0.5	0.7	2.5	0.7	-0.5	1.6	1.1	-0.9	-0.7	-0.1	-0.8	0.1	0.0
Supplements: Vitamin C	0.3	0.4	2.5	-0.3	-0.5	0.2	0.3	-0.3	0.5	-0.3	0.2	1.6	0.8
Knee pain experienced in last month	1.6	2.4	6.2	1.5	0.7	2.4	0.7	-1.2	-1.8	0.5	2.0	-0.3	-2.5
Hypertension (Self-reported)	0.3	0.9	2.7	-1.7	-0.2	-0.6	0.7	-0.1	0.7	-1.0	-0.6	1.2	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.3	-0.7	1.2	-1.2	-1.0	0.1	1.2	-0.2	-0.9	1.5	0.3
Illnesses of father: Heart disease	1.1	1.5	5.9	0.8	-0.5	0.0	1.3	2.4	2.0	1.2	0.3	-0.7	0.7
Illnesses of siblings: Diabetes	1.1	1.4	4.6	0.5	1.1	0.3	0.5	-0.8	0.5	1.7	1.8	2.1	-0.7
Smoking status: Previous	0.6	0.9	5.2	1.1	2.3	0.7	0.3	-0.2	0.4	0.5	0.3	1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	4.4	1.1	2.1	-0.6	0.2	0.1	0.9	1.4	1.8	0.8	-1.2
Whole body fat-free mass	0.4	2.3	10.2	-1.4	1.8	0.4	-1.4	-0.9	1.1	-1.7	0.7	3.2	-0.5
Leg fat-free mass (right)	0.5	2.6	12.1	-1.6	1.5	0.4	-1.8	-0.9	1.1	-1.7	0.6	3.5	-0.2
Arm fat percentage (left)	0.3	1.2	7.7	-0.8	0.8	-0.1	-0.1	-0.3	1.0	-0.4	1.1	2.8	-0.0
Average weekly red wine intake	0.5	0.7	3.3	-0.5	-0.1	0.4	-0.4	1.3	1.8	-0.1	-0.4	1.1	0.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.4	1.1	1.0	0.9	0.5	1.5	1.1	1.2	0.8	-0.8	-1.4
Mood swings	1.1	1.9	4.5	0.3	0.7	2.1	-0.8	-1.7	-1.9	-0.9	0.4	-1.0	-2.1
Loneliness, isolation	0.7	1.0	3.3	1.4	0.9	1.1	1.8	-0.2	-0.5	-0.6	0.0	-0.7	-1.1
Long-standing illness, disability or infirmity	0.6	1.0	3.0	-1.7	-0.3	-0.6	0.4	-0.5	0.6	-1.3	0.0	1.5	1.2
Ever had bowel cancer screening	0.3	0.4	1.3	-0.5	0.1	-0.6	0.5	-0.7	-0.1	-0.4	0.7	1.2	-0.5
Diabetes diagnosed by doctor	0.6	1.0	3.3	-1.5	-0.1	0.7	0.5	-0.5	-0.0	-0.9	-1.2	1.0	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	-0.5	0.7	-0.2	0.6	0.4	0.4	-1.0	-1.3	0.5	1.3
Friendships satisfaction	0.9	1.2	2.8	1.0	0.4	1.5	1.7	-1.2	-0.9	0.4	1.3	0.1	-1.1
Qualifications: nursing, teaching	1.9	2.9	8.4	-2.4	0.4	-0.1	-2.9	1.2	1.4	-1.7	-2.4	0.6	1.6
Commuting to job workplace: Walk	0.8	0.9	2.4	0.2	-0.9	-0.3	-1.5	1.1	1.3	0.9	1.2	0.1	-0.4
Eye problems/disorders: Cataract	1.1	1.2	3.8	0.4	1.6	1.1	-0.6	-0.2	0.7	0.6	1.7	1.9	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.0	-0.8	1.4	0.4	-2.0	0.3	0.8	-1.4	0.2	0.7	-0.4
Medication for cholesterol	0.4	0.6	1.7	-0.3	1.1	-0.6	-1.3	1.0	0.2	-0.2	-1.0	-0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	7.0	-2.5	-0.9	-0.4	0.4	-2.6	-2.0	-2.4	-0.8	0.7	1.7
Back pain experienced in last month	0.8	1.2	4.8	0.9	-1.7	2.2	-0.5	0.9	0.4	0.3	1.1	-0.7	-0.6
Mineral and other dietary supplements	1.1	1.5	4.4	1.8	0.1	0.9	-0.1	0.8	1.0	2.1	1.7	0.0	-1.4
Breast cancer (self-reported)	1.0	1.2	3.0	0.3	-0.9	-1.7	-0.6	1.6	1.5	0.3	-0.2	-0.1	1.5
Asthma (self-reported)	0.1	0.2	0.9	-0.4	-0.2	-0.9	-0.0	0.3	0.1	-0.1	-0.8	-0.7	0.1
Osteoporosis (self-reported)	1.8	2.2	6.4	-2.0	1.3	-1.6	-0.8	0.6	1.1	-0.8	-2.1	0.6	2.5
Osteoarthritis (self-reported)	1.0	1.3	7.7	-1.4	0.2	-2.8	0.0	-0.7	-0.1	-1.3	0.1	0.9	0.4
Medication: Aspirin	0.5	0.7	2.1	0.3	-0.4	1.1	1.4	-1.3	-0.7	-0.5	-0.6	0.5	0.0
Medication: Gliclazide	0.8	0.9	3.2	-0.3	0.8	0.8	1.1	0.1	1.4	0.5	0.8	1.8	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	0.4	0.2	-0.3	0.8	-1.1	-0.8	0.3	0.8	0.5	-1.1
Smoking status: Current	0.6	0.9	2.9	-1.0	-0.7	0.5	-0.7	1.1	0.1	-1.6	-0.5	-1.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.8	-0.2	1.1	1.4	-0.9	-0.9	-0.1	0.6	-0.7	1.3	0.9
Whole body water mass	0.4	2.2	9.8	-1.3	1.7	0.5	-1.4	-1.0	0.9	-1.7	0.8	3.1	-0.6
Leg predicted mass (right)	0.5	2.5	11.4	-1.5	1.5	0.4	-2.0	-0.9	1.1	-1.6	0.6	3.4	-0.2
Arm fat mass (left)	0.4	1.7	10.2	-1.1	1.1	0.0	-0.4	-0.7	0.9	-0.9	1.3	3.2	-0.3
Number of self-reported non-cancer illnesses	1.3	2.2	4.8	-2.0	-1.3	0.8	1.1	-1.8	-0.6	-2.2	0.4	1.9	1.4
Average weekly champagne plus white wine intake	0.4	0.6	2.3	-0.4	1.5	0.4	-1.1	0.3	0.9	0.1	-0.7	0.6	0.3
Miserableness	0.7	1.2	8.8	-0.2	0.8	3.0	-0.9	0.3	0.1	-0.6	0.3	-0.8	-0.7
Guilty feelings	0.6	0.9	2.3	0.9	0.1	0.8	1.3	1.5	1.5	0.4	0.5	-0.5	-1.0
Wears glasses or contact lenses	0.9	1.1	2.7	-0.1	1.5	-0.3	-1.6	1.2	1.6	0.9	-0.6	0.7	0.5
Ever taken oral contraceptive pill	0.7	0.8	4.4	-0.3	-1.0	2.1	-0.3	0.1	-0.2	-0.7	-0.7	-0.6	1.0
Hearing aid user	1.2	1.4	5.8	-0.5	1.8	0.7	0.4	-1.8	-0.1	-0.5	-0.2	2.4	0.2
Mother’s age at death	0.6	0.7	3.5	0.0	0.2	-0.3	-1.9	-1.1	-1.0	0.7	0.3	0.7	0.3
Financial situation satisfaction	0.4	0.5	2.1	1.4	1.1	0.6	0.5	-0.5	-0.2	0.5	0.3	-0.1	-0.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.8	-0.4	-0.5	1.9	-0.4	0.7	1.1	-0.7	0.3	0.6	-0.2
Commuting to job workplace: Public transport	0.8	1.0	3.0	-0.7	-0.3	0.1	-1.7	1.4	1.6	-0.8	-0.8	0.0	0.5
Eye problems/disorders: Glaucoma	0.6	0.7	2.2	0.7	-1.0	0.4	-1.0	-0.6	0.3	0.9	0.9	1.5	-0.6
Medication: Blood pressure	0.2	0.3	1.5	0.3	-0.8	-0.1	1.2	0.1	0.5	0.5	-0.1	0.5	0.7
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.5	0.9	-0.2	2.1	2.0	-0.3	-0.9	0.3	0.0	-0.6	-0.9
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.9	-1.7	1.1	-0.1	-0.9	-2.0	-1.7	-2.2	-1.3	0.7	1.0
High cholesterol (Self-reported)	1.0	1.8	7.7	0.0	-1.7	0.5	2.8	-1.6	-1.8	-1.2	0.1	-0.1	-0.3
Medication: Bendroflumethiazide	0.5	0.8	2.9	0.6	1.7	-0.6	0.0	0.2	1.0	1.4	-0.0	1.1	0.4
Medication: Paracetamol	0.6	0.9	3.3	-0.3	-0.7	-0.2	1.3	-0.8	-0.6	0.5	-1.2	0.6	1.8
Medication: Lisinopril	0.5	0.6	1.6	0.0	0.6	-1.1	0.3	1.3	1.0	0.8	0.9	-0.3	-0.0
Medication: Atorvastatin	0.9	1.1	3.0	1.0	-0.1	0.4	1.4	0.7	-0.5	1.1	1.3	-1.7	-1.2
Illnesses of father: High blood pressure	1.1	1.4	7.6	-1.3	-0.6	-0.1	-0.8	-1.2	-0.7	-2.8	-1.1	0.1	0.8
Alcohol drinker status: Never	2.3	2.8	8.8	-1.4	0.7	-2.2	0.2	-3.0	-1.3	-1.4	-0.3	2.5	1.1
Ever smoked	0.6	1.1	4.2	-0.8	1.8	-0.0	-2.0	-0.6	-0.4	-1.2	-0.4	0.1	0.6
Basal metabolic rate	0.4	2.2	10.8	-1.3	1.6	0.4	-1.2	-0.9	1.0	-1.5	1.0	3.3	-0.5
Leg fat percentage (left)	0.3	1.1	4.0	-0.1	0.9	-0.8	1.2	-0.4	0.5	0.4	1.7	2.0	-0.4
Arm fat-free mass (left)	0.2	1.3	5.2	-0.8	0.8	0.3	-0.4	-1.2	0.2	-1.4	1.3	2.3	-0.9
Number of operations (self-reported)	0.2	0.4	1.2	-0.4	0.5	-0.6	0.7	0.6	0.4	-0.0	-0.8	0.1	1.1
Average weekly beer plus cider intake	0.4	0.6	1.7	0.5	-1.3	-0.2	0.5	-0.2	-0.5	1.3	0.9	-0.5	-1.1
Irritability	0.7	1.2	4.8	-1.7	0.6	-1.0	0.5	-0.8	-0.3	-2.2	-0.9	0.8	0.5
Risk taking	0.9	1.4	5.8	-2.3	-0.7	0.1	-0.6	-0.5	0.1	-2.4	-0.6	0.7	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.1	3.4	-0.9	1.8	-0.9	0.7	0.2	1.3	0.4	-0.3	1.8	0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.5	1.0	-0.0	0.5	0.5	-1.0	-1.2	0.7	0.8	-0.1	-0.4
Age started oral contraceptive pill	0.3	0.3	2.2	0.0	-0.4	0.4	1.5	-0.1	-0.4	-0.2	-0.5	-0.4	0.3
Diastolic blood pressure, automated reading	1.1	3.3	7.6	-2.7	0.8	-1.4	-0.8	1.1	1.6	-2.5	-2.8	0.6	2.1
Ever depressed for a whole week	0.9	1.1	3.9	0.9	0.3	1.4	-0.9	0.1	0.1	1.0	1.5	0.2	-2.0
Unable to work because of sickness or disability	1.0	1.3	4.0	-1.7	1.4	0.4	-0.6	-0.5	0.4	-2.0	1.0	1.5	0.2
Commuting to job workplace: Cycle	0.8	1.0	2.9	-1.7	0.5	0.6	-1.2	0.1	-0.3	-1.5	-1.3	-0.4	0.9
Myopia	1.0	1.4	5.6	-0.7	1.7	-0.5	-1.0	-0.5	1.3	-0.7	-0.4	2.4	1.2
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.5	1.1	0.6	0.1	-0.9	0.8	0.1	1.0	0.5	-1.2	-1.0
Cholesterol lowering medication	0.6	0.9	2.8	-0.5	-1.1	-1.2	1.7	-0.6	0.0	-0.4	0.8	1.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	4.3	0.6	1.6	0.2	1.6	-2.1	-1.4	0.5	0.1	1.0	-0.0
Pain experienced in last month	1.5	2.6	6.5	-1.8	0.2	-2.4	-2.6	0.8	1.5	-0.9	-2.1	0.7	1.1
Supplements: Calcium	0.2	0.2	0.9	-0.1	-0.8	-0.7	-0.2	0.5	0.3	0.2	1.0	-0.2	-0.2
Basal cell carcinoma (self-reported)	0.6	0.7	5.4	0.4	-0.3	0.6	2.3	-0.1	-0.5	0.7	-0.2	-0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.4	0.1	-1.1	1.6	1.5	-0.4	-0.9	-0.4	0.8	-0.6	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	5.1	-0.9	1.5	0.2	1.1	-1.4	0.3	-0.9	0.6	2.3	-0.0
Heart disease (siblings)	1.0	1.2	2.8	-1.2	0.1	-0.8	1.5	-1.5	-0.6	-1.2	0.1	1.7	1.0
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.9	0.5	-0.4	0.2	-0.1	0.6	-0.6	-0.1	0.6	0.7
Pack years of smoking	1.1	1.6	4.9	-2.2	-1.1	-0.4	-0.6	0.0	-0.9	-1.5	-1.6	-1.5	1.4
Impedance of whole body	0.8	4.0	12.8	2.4	-1.8	-1.9	2.7	1.3	-0.1	3.6	1.0	-2.2	-0.0
Leg fat mass (left)	0.3	1.1	5.7	-1.2	0.9	-0.8	0.2	-0.2	1.0	-0.8	1.1	2.4	0.1
Arm predicted mass (left)	0.3	1.4	6.5	-0.8	1.1	0.4	-0.7	-1.0	0.5	-1.3	1.3	2.5	-0.9