TWAS hub - STXBP5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0830	0.0230	3.1e-09	0.081	0.078	0.092	0.077	0.081	4.8e-10	1.0e-09	2.4e-11	1.1e-09	4.5e-10
2	GTEx	Heart Left Ventricle	0.1779	0.0775	6.5e-03	-0.004	NA	0.012	NA	-0.004	6.9e-01	NA	7.3e-02	NA	6.2e-01
3	YFS	Blood	0.0694	0.0175	1.8e-14	0.040	0.040	0.042	0.042	0.047	5.7e-13	3.6e-13	8.7e-14	1.2e-13	4.6e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Age when periods started (menarche)	7.0	16.7	31.0	4.3	-0.8	5.6
Happiness	6.9	8.4	14.5	3.2	-0.7	3.8
Diastolic blood pressure, automated reading	6.7	20.7	34.5	-5.9	2.3	-4.7
Systolic blood pressure, automated reading	6.4	18.5	32.7	-5.7	2.2	-4.2
Osteoporosis (self-reported)	5.2	6.4	12.6	2.4	-3.5	0.9
Neuroticism (Nagel 2018)	4.7	11.1	13.9	3.7	-2.7	3.5
Fed-up feelings	4.6	8.4	12.9	3.4	-0.7	3.6
Health satisfaction	4.6	6.0	11.7	2.3	-1.0	3.4
Depressed Affect (Nagel 2018)	4.0	8.4	11.8	3.4	-1.8	3.2
Worry too long after embarrassment	3.9	6.5	8.2	2.9	-2.2	2.5
Supplements: Vitamin C	3.6	4.2	6.5	-2.1	2.5	-1.3
Neuroticism	3.5	8.4	14.4	3.8	-1.7	2.8
Neuroticism score	3.4	7.2	9.9	3.2	-1.9	2.8
Birth weight of first child	3.4	6.1	11.9	-3.4	0.9	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	9.3	1.1	-1.7	3.0
Illnesses of father: High blood pressure	3.3	4.1	7.0	-1.9	2.6	-1.3
Medication for hormone replacement therapy	3.2	3.6	6.1	-2.5	1.6	-1.4
Alzheimer’s Disease (in mother)	3.1	3.7	5.6	-2.1	2.4	-1.0
Diverticular disease/diverticulitis (self-reported)	3.1	3.7	5.2	-2.2	1.1	-2.3
Miserableness	3.1	5.4	6.9	2.3	-2.0	2.6
Systolic Blood Pressure	3.0	14.9	24.7	-5.0	2.0	-4.0
Ever taken oral contraceptive pill	3.0	3.3	4.0	-1.7	2.0	-1.7
Ever had hysterectomy (womb removed)	2.9	3.3	6.0	-2.5	1.9	-0.6
Father’s age at death	2.9	4.0	6.0	2.4	-2.4	0.3
Leg fat mass (right)	2.9	11.1	22.3	-4.7	2.7	-1.9
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	6.8	-1.5	-0.6	-2.6
Tense / ‘highly strung’	2.8	4.6	10.1	1.7	-0.9	3.2
Arm fat percentage (left)	2.7	10.7	20.2	-4.5	3.0	-1.6
Loneliness, isolation	2.7	3.7	4.4	1.9	-1.8	2.1
Age at First Birth	2.6	3.8	5.6	-0.5	-2.4	-2.4
Neuroticism (2016)	2.6	3.7	5.1	2.1	-1.2	2.3
Arm fat percentage (right)	2.6	10.2	19.4	-4.4	3.0	-1.5
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.1	8.3	1.7	-1.2	2.9
Leg fat percentage (right)	2.6	9.4	20.5	-4.5	1.9	-2.0
Suffer from ‘nerves’	2.6	4.1	4.8	2.2	-1.7	2.1
Arm fat mass (left)	2.6	10.5	19.1	-4.4	3.3	-1.3
Leg fat mass (left)	2.6	10.1	19.6	-4.4	2.8	-1.7
Arm fat mass (right)	2.5	10.1	18.4	-4.3	3.2	-1.3
Comparative body size at age 10	2.5	6.9	8.9	-3.0	2.4	-2.5
Whole body fat mass	2.5	10.6	20.5	-4.5	2.9	-1.6
Smoking status: Current	2.5	4.0	7.2	1.5	-2.7	1.6
Had other major operations	2.4	2.9	5.0	-1.5	2.2	-1.3
Alcohol drinker status: Never	2.4	2.9	4.2	-2.0	0.5	-2.0
Commuting to job workplace: Cycle	2.4	2.9	4.6	1.4	1.5	2.1
Major Depression (MDD)	2.3	2.7	3.9	2.0	-0.8	1.9
Blood clot in the leg (DVT)	2.3	2.9	5.6	2.4	-1.0	1.5
Body fat percentage	2.3	9.2	18.1	-4.2	2.6	-1.7
Worry (Nagel 2018)	2.2	4.6	7.0	2.1	-1.5	2.6
Hearing difficulty/problems with background noise	2.2	3.5	6.2	2.5	-0.0	2.0
Noisy workplace	2.2	2.7	6.6	1.0	0.7	2.6
Loud music exposure frequency	2.2	2.4	5.2	0.6	1.3	2.3
Medication: Atorvastatin	2.2	2.7	5.7	1.5	-0.4	2.4
Leg fat percentage (left)	2.2	7.9	15.8	-4.0	2.1	-1.8
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	5.5	2.3	-0.5	1.7
BMI	2.1	12.0	23.3	-4.8	3.4	-1.1
Current tobacco smoking	2.1	3.5	5.7	1.3	-2.4	1.7
Trunk fat mass	2.1	9.0	16.6	-4.1	2.9	-1.4
Medication: Amlodipine	2.1	2.9	4.5	-2.1	-1.3	-1.6
Number of full brothers	2.1	2.6	5.1	-1.3	1.0	-2.2
Supplements: Fish oil (including cod liver oil)	2.1	2.7	7.8	-0.5	-0.4	-2.8
Blood White Count	2.0	14.9	29.5	3.3	-2.0	5.4
Sensitivity / hurt feelings	2.0	3.4	5.1	2.0	-2.2	1.1
Trunk fat percentage	2.0	8.0	14.4	-3.8	2.8	-1.3
Body mass index (BMI)	2.0	8.4	16.8	-4.1	2.7	-1.0
Waist circumference	2.0	7.2	13.6	-3.7	2.7	-0.7
Hip circumference	2.0	8.8	17.1	-4.1	2.8	-1.3
Fractured/broken bones in last 5 years	2.0	2.6	6.9	0.4	-2.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.2	8.8	-3.0	1.4	-1.3
Weight	1.9	9.2	16.9	-4.1	3.1	-1.0
Number of children fathered	1.9	2.2	3.3	-1.1	1.4	-1.8
Neck or shoulder pain in last month	1.9	2.7	4.1	2.0	-0.1	2.0
Mineral and other dietary supplements	1.9	2.5	7.2	0.6	0.1	2.7
Guilty feelings	1.9	2.8	3.6	1.9	-1.8	1.3
Wears glasses or contact lenses	1.9	2.2	3.2	-1.8	1.7	-0.8
Ever depressed for a whole week	1.9	2.4	3.2	1.8	-1.1	1.6
Nervous feelings	1.8	3.4	4.8	1.3	-1.9	2.2
Time employed in main current job	1.8	2.1	2.8	1.5	1.7	1.1
Pulse wave Arterial Stiffness index	1.8	2.1	5.5	0.5	-2.3	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	5.1	-2.2	-0.5	-1.0
Pulse wave peak to peak time	1.8	2.2	5.6	-0.5	2.4	0.8
Smoking status: Previous	1.8	2.7	3.5	-1.6	1.9	-1.4
Number of self-reported non-cancer illnesses	1.8	3.1	7.7	-2.8	1.1	-0.6
Chronotype (morning person)	1.7	3.9	10.7	-0.4	-0.9	-3.3
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	5.2	-2.3	2.2	-1.3
Medication: Gliclazide	1.7	1.9	4.6	-2.1	1.1	-0.0
Myopia	1.7	2.5	6.2	1.1	-2.5	-0.2
Cardiovascular Disease	1.6	5.3	10.9	-3.3	1.8	-1.3
Hearing difficulty/problems: Yes	1.6	2.4	5.7	0.3	1.2	2.4
Vitamin and mineral supplements	1.6	2.2	5.3	1.0	-0.5	2.3
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	4.6	0.9	0.7	2.1
Irritability	1.6	2.6	5.6	1.4	0.6	2.4
HbA1C	1.5	1.7	2.5	-1.6	1.3	-0.9
Taking other prescription medications	1.5	2.3	3.0	1.7	-1.4	1.4
Stomach or abdominal pain in last month	1.5	1.9	3.0	0.8	-1.4	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	3.2	1.1	-1.2	1.8
Shortness of breath walking on level ground	1.5	1.8	5.2	-0.2	0.2	2.3
Emphysema/chronic bronchitis	1.5	1.7	3.1	-1.8	0.8	1.2
Comparative height size at age 10	1.5	8.2	12.0	-3.5	2.7	-2.3
Depression (Nagel 2018)	1.4	2.1	3.3	1.0	-1.4	1.8
Multivitamins +/- minerals	1.4	1.8	4.4	-1.0	-0.1	-2.1
Alcohol intake versus 10 years previously	1.4	2.1	3.1	-1.2	1.7	1.3
Overall health rating	1.4	3.1	7.1	0.8	-1.2	2.7
Commuting to job workplace: Car/motor vehicle	1.4	1.5	2.5	-1.1	1.0	-1.6
Financial situation satisfaction	1.4	1.8	5.0	-0.0	-0.5	2.2
Alzheimer’s Disease (including proxy)	1.3	1.9	4.5	-1.1	2.1	0.1
Breast Cancer	1.3	3.1	7.1	1.2	-2.7	1.0
Diabetes (father)	1.3	1.6	2.4	-1.0	-1.2	-1.6
Worrier / anxious feelings	1.3	2.5	2.8	1.5	-1.6	1.7
High blood pressure (siblings)	1.3	1.9	3.3	-1.2	-0.9	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.5	-1.0	-1.6	-1.1
Illnesses of father: Heart disease	1.3	1.9	2.7	1.6	-0.7	1.6
Risk taking	1.3	1.9	3.2	0.3	1.6	1.8
Heel T-Score	1.2	9.8	18.3	-3.0	4.3	-1.5
Financial difficulties in last 2 years	1.2	1.6	4.6	-2.1	-0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.7	0.1	0.8	2.2
Pulse wave reflection index	1.2	1.5	3.1	0.7	-0.9	1.8
Leg predicted mass (left)	1.1	5.6	9.1	-3.0	2.7	-0.5
Alcohol usually taken with meals	1.1	1.8	2.7	-0.7	1.5	-1.6
Birth weight	1.1	2.4	4.5	-2.1	1.2	-1.2
Leg pain on walking	1.1	1.4	3.6	0.1	0.7	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.6	0.6	1.0	1.6
Mood swings	1.1	1.9	2.7	1.6	0.7	1.6
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.0	1.2	-0.7	1.4
Commuting to job workplace: Public transport	1.1	1.3	2.6	0.7	-1.0	1.6
Medication: Lisinopril	1.1	1.4	2.6	1.0	-1.6	0.9
Crohns Disease (2012)	1.0	1.7	2.1	-1.5	1.3	-1.1
Leg fat-free mass (left)	1.0	5.5	8.8	-3.0	2.7	-0.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.7	-1.6	0.9	-0.5
High blood pressure (mother)	1.0	1.5	4.0	-2.0	0.5	-0.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.3	0.1	1.5	1.1
Length of working week for main job	1.0	1.2	2.8	0.1	-0.8	1.7
Gout (self-reported)	1.0	1.4	2.1	-1.4	-1.4	0.2
Eye problems/disorders: None of the above	1.0	1.1	3.2	0.4	1.8	-0.1
Medication for pain relief, constipation, heartburn	1.0	1.7	2.6	-0.6	1.5	-1.6
Qualifications: nursing, teaching	1.0	1.6	2.3	-0.3	-1.5	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.6	-0.2	-1.6	-0.8
Basal metabolic rate	1.0	5.4	8.7	-3.0	2.7	-0.4
Age started oral contraceptive pill	1.0	1.2	1.7	1.3	-0.7	1.2
Arm predicted mass (left)	1.0	4.9	7.7	-2.8	2.6	-0.5
Coronary Artery Disease (CAD)	0.9	1.1	2.1	-1.1	1.5	0.0
LDL Cholesterol	0.9	1.4	2.0	-0.6	-1.4	-1.3
Triglycerides	0.9	1.5	2.4	-0.8	-1.2	-1.5
Respiratory disease	0.9	2.1	3.7	1.3	-0.9	1.9
High blood pressure	0.9	2.6	5.8	-2.4	1.4	-0.2
Forced vital capacity (FVC), Best measure	0.9	3.2	5.2	2.3	-1.4	1.5
Arm predicted mass (right)	0.9	4.6	6.9	-2.6	2.5	-0.6
Pulse rate, automated reading	0.9	2.8	3.8	-1.5	1.5	-1.9
Family relationship satisfaction	0.9	1.1	2.4	1.6	0.2	0.9
Ovarian Cancer	0.8	1.1	1.3	0.8	-1.1	1.2
Blood Platelet Count	0.8	9.2	19.0	-4.4	2.2	-2.0
Lung FVC	0.8	4.2	7.1	2.2	-2.7	0.9
Townsend deprivation index at recruitment	0.8	1.2	2.1	0.3	-1.1	1.5
Average weekly fortified wine intake	0.8	0.9	1.5	-1.1	-0.3	-1.2
Qualifications: CSEs or equivalent	0.8	1.1	2.4	-0.8	-0.6	-1.5
Mouth/teeth dental problems	0.8	1.2	1.3	1.1	1.1	-1.0
Illnesses of siblings	0.8	1.1	2.7	1.6	-0.6	0.7
Falls in the last year	0.8	1.0	1.8	0.8	-1.3	0.8
Number of live births	0.8	1.1	1.8	1.4	1.1	0.6
Pulse rate	0.8	1.4	3.5	-0.4	0.7	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	4.6	2.1	-1.4	1.3
Arm fat-free mass (right)	0.8	4.0	6.2	-2.5	2.3	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.5	-0.3	0.7	1.6
Leg fat-free mass (right)	0.8	4.5	7.5	-2.5	2.7	-0.3
Leg predicted mass (right)	0.8	4.3	7.3	-2.4	2.7	-0.3
Medication: Paracetamol	0.8	1.3	3.4	-0.5	-1.9	0.5
Number of operations (self-reported)	0.8	1.2	2.0	-1.3	1.4	0.1
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.3	2.1	-1.3	0.3
Basal cell carcinoma (self-reported)	0.8	1.0	1.9	1.0	0.0	1.4
Hypothyroidism (self reported)	0.7	1.5	2.3	-1.5	1.0	-1.2
Number of treatments/medications taken	0.7	1.3	1.8	0.9	-1.3	1.1
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.2	0.6	-1.1	1.1
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.6	-1.3	0.4	-0.9
Diabetes (mother)	0.7	0.8	0.9	-0.9	1.0	-0.9
Severe depression (siblings)	0.7	0.8	1.3	1.1	-0.1	1.2
Maternal smoking around birth	0.7	1.1	2.6	-1.6	0.6	0.4
Serious illness, injury or assault to yourself	0.7	0.9	2.3	0.5	-0.1	1.5
Number of incorrect matches in round	0.7	1.1	2.2	-0.6	-1.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.6	-1.0	-0.7	1.2
Pain all over the body in last month	0.7	0.8	1.7	-0.6	1.3	0.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.7	-1.6	0.6	-1.1
Heart disease (mother)	0.7	0.8	1.4	0.5	-0.9	1.2
Had major operations	0.7	0.8	1.3	1.1	0.0	1.1
Medication: Aspirin	0.7	1.0	1.4	0.3	-1.2	1.2
Hypertension (Self-reported)	0.7	2.1	4.3	-2.1	1.3	-0.3
Whole body fat-free mass	0.7	3.8	5.8	-2.4	2.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.5	-0.1	-0.9	1.6
Whole body water mass	0.7	4.0	6.0	-2.4	2.4	-0.3
Medication: Blood pressure	0.7	1.3	3.4	0.7	0.4	1.8
Arm fat-free mass (left)	0.7	3.7	5.8	-2.4	2.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.2	0.4	1.1	1.1
Pack years of smoking	0.7	1.1	1.5	-1.2	-0.5	-1.2
Crohns Disease (2017)	0.6	1.3	2.3	-1.5	0.9	-0.9
Supplements: Zinc	0.6	0.6	1.7	-0.4	0.2	-1.3
Medication: Atenolol	0.6	0.8	1.9	0.2	1.4	0.6
Past tobacco smoking	0.6	1.2	1.5	1.1	-1.2	0.9
Medication: Ramipril	0.6	0.8	1.5	1.0	0.1	1.2
Medication: Ibuprofen	0.6	0.8	1.5	0.8	-0.4	1.2
Medication: Seretide 50 evohaler	0.6	0.7	1.2	-1.1	0.8	-0.5
Long-standing illness, disability or infirmity	0.6	0.9	1.5	-1.2	0.6	0.8
Breast cancer (self-reported)	0.6	0.7	1.3	0.4	-0.8	1.1
High cholesterol (Self-reported)	0.6	1.0	2.7	-0.6	-1.6	0.2
Pain experienced in last month	0.6	1.0	2.4	-0.8	-0.0	-1.6
Heart disease (siblings)	0.6	0.7	1.8	-0.6	1.4	0.2
Bipolar Disorder (2011)	0.5	0.4	0.6	0.7	0.6	0.7
Body Mass Index (BMI) (2010)	0.5	0.6	1.1	-0.9	-0.1	-1.1
Primary Biliary Cirrhosis	0.5	0.7	1.9	-0.5	0.2	-1.4
Schizophrenia (2014)	0.5	1.0	2.9	0.3	-1.7	0.1
Impedance of leg (left)	0.5	2.6	4.1	1.9	-2.0	0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.3	1.5	-0.9	0.0
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	-1.3	0.6	-0.4
Peak expiratory flow (PEF)	0.5	1.1	1.9	1.2	-1.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.2	0.3	-1.0	-1.1
Medication: Paracetamol	0.5	0.8	1.8	0.0	-1.3	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.8	0.2	1.3	0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.2	-0.6	1.1	-0.7
Exposure to tobacco smoke outside home	0.5	0.7	2.1	0.3	-0.0	1.4
Medication: Omeprazole	0.5	0.6	1.2	0.1	0.7	1.1
Alcohol intake frequency.	0.5	1.2	2.3	-1.5	0.1	-1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	-0.0	-0.4	-1.2
Ever had bowel cancer screening	0.5	0.6	1.2	0.5	1.1	0.5
Medication for cholesterol	0.5	0.7	1.2	0.8	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.0	1.4	-0.7	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.9	0.3	0.9	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.6	1.6	-0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.8	1.7	-0.3	0.3
Ulcerative Colitis	0.4	0.6	1.0	-0.9	1.0	-0.1
Average weekly spirits intake	0.4	0.5	1.1	-0.2	1.0	0.5
Impedance of leg (right)	0.4	2.0	4.7	1.1	-2.2	-0.3
Hand grip strength (right)	0.4	1.1	3.1	1.7	0.2	0.5
Relative age voice broke	0.4	0.7	1.2	-0.6	1.1	0.6
Supplements: Glucosamine	0.4	0.5	1.1	1.1	-0.7	-0.1
Forced vital capacity (FVC)	0.4	1.5	2.6	1.3	-1.6	0.6
Qualifications: None of the above	0.4	0.8	1.2	-0.8	1.1	0.8
Heart attack	0.4	0.5	0.8	0.3	0.8	0.9
Trunk fat-free mass	0.4	2.4	4.0	-2.0	1.8	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.1	1.5	-1.4	0.6
Lung cancer (father)	0.4	0.4	0.7	-0.7	-0.3	-0.8
Trunk predicted mass	0.4	2.1	3.6	-1.9	1.6	-0.0
Exposure to tobacco smoke at home	0.4	0.5	0.7	-0.7	0.8	0.5
Breastfed as a baby	0.4	0.5	0.9	-0.4	0.7	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	0.3	-0.5	1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-0.7	-0.4	1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	-1.1	0.1	-0.5
Age at first live birth	0.4	0.7	1.1	1.1	0.6	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	0.5	0.9	0.7
Medication: Blood pressure	0.4	0.7	1.1	-0.9	-0.5	-1.0
Migraine (self-reported)	0.4	0.5	0.7	0.2	-0.8	0.9
Medication: Allopurinol	0.4	0.6	1.2	-0.6	-1.1	0.4
Number of full sisters	0.4	0.5	1.4	-0.4	1.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	0.8	0.9	0.1
Back pain experienced in last month	0.4	0.5	1.1	-0.0	0.7	1.0
Medication: Aspirin	0.4	0.5	1.1	-0.2	-1.1	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.2	-0.4	1.1	0.1
Cholesterol lowering medication	0.4	0.6	1.6	0.1	-0.4	1.3
Impedance of whole body	0.4	2.2	3.7	1.7	-1.9	0.0
Schizophrenia (2018)	0.3	0.7	2.0	0.2	-1.4	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.9	-0.6	0.1
Allergy or Eczema	0.3	0.7	1.9	0.3	0.0	-1.4
Tanning	0.3	4.2	6.4	-2.3	1.0	-2.5
Relative age of first facial hair	0.3	0.6	1.8	0.2	0.3	1.4
Angina	0.3	0.4	1.0	-1.0	0.2	0.5
Pack years adult smoking proportion	0.3	0.4	0.8	-0.9	-0.3	-0.6
Had menopause	0.3	0.4	1.0	0.3	0.4	1.0
Impedance of arm (right)	0.3	1.4	2.1	1.4	-1.5	0.3
Depression (self-reported)	0.3	0.4	0.5	0.7	0.3	0.7
Medication: Lansoprazole	0.3	0.3	0.4	0.6	0.4	0.7
Illnesses of mother	0.3	0.3	0.7	0.8	-0.6	-0.2
Impedance of arm (left)	0.3	1.5	2.6	1.6	-1.3	0.5
Headache pain in last month	0.3	0.6	1.3	-0.1	-1.1	-0.6
Glaucoma (self-reported)	0.3	0.3	0.5	-0.4	0.7	-0.6
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	0.6	-0.7	0.9
Angina (self-reported)	0.3	0.4	0.6	-0.8	0.0	0.8
Age at last live birth	0.3	0.4	1.2	1.1	0.1	-0.3
Commuting to job workplace: Walk	0.3	0.3	0.4	-0.6	-0.6	-0.5
Eye problems/disorders: Cataract	0.3	0.3	0.8	-0.0	-0.9	0.3
Hearing aid user	0.3	0.3	0.8	-0.4	-0.9	-0.2
Mother’s age at death	0.3	0.4	0.6	0.2	-0.7	-0.8
Medication: Bendroflumethiazide	0.3	0.4	0.9	-0.9	0.4	-0.6
Ever smoked	0.3	0.4	0.8	-0.6	0.9	-0.3
Supplements: Calcium	0.3	0.3	0.9	0.9	-0.3	-0.1
Bipolar Disorder (2018)	0.2	0.4	0.6	0.7	0.7	-0.1
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	-0.8	0.7	0.1
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.2	0.2	0.9
Fasting Glucose	0.2	0.2	0.5	0.7	-0.2	-0.1
Rheumatoid Arthritis	0.2	0.2	0.3	0.4	0.4	0.5
Blood Eosinophil Count	0.2	1.9	4.3	1.0	-0.6	2.1
Smoking Status	0.2	0.5	1.4	-0.2	-1.2	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	0.4	0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	-0.8	-0.3	-0.1
Medication: Metformin	0.2	0.3	1.0	-0.2	0.1	1.0
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.7	0.6	0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.6	-0.6	-0.2
Allergy	0.2	0.4	0.8	-0.9	0.7	-0.1
Diabetes (self-reported)	0.2	0.3	0.4	0.6	-0.5	0.5
Fluid intelligence score	0.2	0.4	0.6	0.8	-0.2	-0.7
Mean time to correctly identify matches	0.2	0.4	1.1	-0.1	0.2	1.1
Chest pain or discomfort	0.2	0.3	0.8	-0.5	0.1	0.9
Knee pain experienced in last month	0.2	0.3	0.8	-0.1	0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.6	0.4	-0.8	0.5
Friendships satisfaction	0.2	0.2	0.5	0.7	-0.2	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.5	0.0	0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.7	0.2	0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.6	-0.0	-0.6
Average weekly beer plus cider intake	0.2	0.2	0.4	0.5	0.2	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.2	-0.0	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	0.6	-0.6	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.0	0.4	0.4
Reaction Time	0.1	0.1	0.2	-0.2	0.2	0.5
Mean Putamen Volume	0.1	0.1	0.2	-0.1	-0.4	-0.4
HDL Cholesterol	0.1	0.2	0.5	0.7	-0.2	0.4
Lupus	0.1	0.1	0.3	0.6	0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.3	0.1	-0.3
Height	0.1	2.2	4.0	1.0	2.0	1.3
Waist Hip Ratio (WHR)	0.1	0.6	1.1	0.8	0.1	1.1
Hand grip strength (left)	0.1	0.3	0.8	0.9	0.1	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.5	-0.1	-0.1
Medication: Co-codamol	0.1	0.1	0.2	-0.1	-0.5	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.1	-0.1	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.3	-0.3	-0.7
Sitting height	0.1	0.9	2.3	-0.1	1.5	0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.1	-0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.3	0.7	0.1
Medication: Simvastatin	0.1	0.1	0.4	-0.2	-0.6	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.3	0.5	0.2
Prospective memory result	0.1	0.2	0.3	0.4	-0.1	0.6
Qualifications: College or University degree	0.1	0.2	0.4	0.2	-0.5	-0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.4	0.2	0.6
Average weekly red wine intake	0.1	0.1	0.2	-0.1	0.4	-0.3
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.1	0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.2	0.5	-0.3	0.4
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	-0.0	0.7	-0.1
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.3	-0.2	0.6
Alcohol drinker status: Previous	0.1	0.2	0.2	-0.3	-0.4	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.1	0.2	-0.4	-0.2	-0.2
Lung FEV1/FVC ratio	0.0	0.0	0.1	0.0	0.2	-0.3
Hair Pigment	0.0	0.1	0.1	0.3	0.3	-0.0
Asthma	0.0	0.0	0.0	-0.0	-0.2	-0.1
Medication: Cholesterol lowering	0.0	0.1	0.1	0.2	-0.4	0.1
Standing height	0.0	0.5	1.3	-0.2	1.2	0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.4	-0.3	0.3
Asthma (self-reported)	0.0	0.0	0.1	0.1	-0.2	0.0

Hub : Genes

STXBP5

Models

Trait associations