Hub : Genes

SUDS3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0790	0.0210	1.1e-08	0.040	0.081	0.081	0.073	0.043	1.0e-05	4.5e-10	4.6e-10	3.0e-09	4.7e-06
2	GTEx	Artery Tibial	0.1225	0.0395	1.4e-06	0.106	NA	0.074	NA	0.091	1.3e-08	NA	1.9e-06	NA	1.3e-07
3	METSIM	Adipose	0.0451	0.0175	3.9e-05	0.047	0.026	0.037	0.028	0.045	1.1e-07	6.3e-05	2.3e-06	3.5e-05	2.2e-07
4	TCGA	Brain Lower Grade Glioma	0.0662	0.0321	7.4e-05	-0.002	0.033	0.028	NA	0.014	5.5e-01	1.1e-04	3.1e-04	NA	8.2e-03
5	TCGA	Thyroid Carcinoma	0.1130	0.0490	6.0e-10	0.066	0.097	0.102	NA	0.097	5.4e-07	1.2e-09	4.2e-10	NA	1.2e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	1.1	0.7	0.2	-0.5	1.0	-0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.4	1.0	0.3	-0.7	1.6	-0.9
Depressed Affect (Nagel 2018)	7.4	15.6	19.3	-3.7	4.4	4.1	4.2	3.3
Depression (Nagel 2018)	12.3	18.4	22.0	-4.3	4.7	4.6	3.8	4.0
Intelligence (Savage-Jansen 2018)	1.3	3.9	7.4	-1.3	2.4	1.7	2.7	1.4
Neuroticism (Nagel 2018)	11.2	26.4	37.0	-4.7	6.1	4.9	5.6	4.1
Schizophrenia (2018)	0.3	0.6	1.6	0.6	0.2	-0.5	1.3	-0.7
Schizophrenia vs Biploar Disorder	0.0	0.0	0.2	-0.0	0.0	-0.4	-0.1	-0.3
Worry (Nagel 2018)	4.7	9.8	15.6	-2.8	4.0	3.0	3.4	2.3
Alzheimer’s Disease (in mother)	0.5	0.5	1.0	0.5	-1.0	-0.7	-0.9	0.1
Alzheimer’s Disease (in father)	0.5	0.6	1.3	-0.4	0.9	0.7	1.2	0.3
Alzheimer’s Disease (including proxy)	0.3	0.5	0.9	-0.5	0.7	0.4	0.6	0.9
Crohns Disease (2017)	0.0	0.1	0.2	0.0	0.3	-0.1	-0.0	-0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.1	0.1	-0.6	-0.1	-0.7
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.2	-0.4	-0.7	-0.5	-0.5
Major Depression (MDD)	7.5	9.1	13.5	-2.5	3.7	3.1	3.1	2.6
Reaction Time	1.6	3.1	4.7	-1.3	2.2	1.9	1.9	1.3
Verbal and Numeric Reasoning (VNR)	1.2	2.8	4.3	-1.2	2.1	1.8	2.0	1.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.7	0.9	3.2	-0.5	0.9	0.5	1.8	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.0	0.0	0.6	0.3	1.0	-0.2
Bipolar Disorder (2011)	0.5	0.5	0.6	0.6	0.7	-0.7	0.8	-0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	-0.7	-0.7	-0.1	-0.4
Coronary Artery Disease (CAD)	0.4	0.5	1.6	-0.2	0.9	0.3	1.2	0.2
Crohns Disease (2012)	0.4	0.7	1.9	0.6	0.2	-1.0	0.4	-1.4
Mean Putamen Volume	2.3	2.6	4.3	2.1	-1.2	-1.9	-0.7	-1.8
Fasting Glucose	0.2	0.2	0.6	-0.5	0.1	-0.4	-0.8	-0.0
HbA1C	0.5	0.6	1.1	-0.4	0.3	0.8	-0.9	1.1
HDL Cholesterol	2.2	3.6	4.8	1.7	-2.2	-2.1	-1.8	-1.7
LDL Cholesterol	1.2	1.9	2.9	-1.7	1.3	1.2	1.6	1.1
Lupus	0.4	0.5	2.0	0.0	0.6	0.3	1.4	0.4
Neuroticism (2016)	14.2	20.4	24.6	-4.8	5.0	4.6	3.6	4.5
Primary Biliary Cirrhosis	0.2	0.3	1.4	0.0	0.2	1.2	0.3	0.1
Rheumatoid Arthritis	0.2	0.2	0.5	-0.3	0.3	0.4	-0.6	0.7
Schizophrenia (2014)	0.5	1.2	4.8	-0.3	1.0	0.1	2.2	-0.2
Triglycerides	0.0	0.1	0.2	-0.4	0.2	-0.0	0.5	-0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	-1.0	0.4	0.5	0.1	0.3
Ulcerative Colitis	0.4	0.6	1.1	0.1	-0.7	-1.0	-0.7	-1.0
Blood Eosinophil Count	0.1	0.5	0.9	0.8	-0.8	-0.3	-1.0	-0.4
Blood Platelet Count	0.2	2.2	4.2	-0.8	1.6	2.0	1.1	1.6
Blood Red Count	0.5	5.2	10.3	1.0	-3.1	-2.1	-3.2	-1.0
Blood White Count	0.5	3.6	6.2	2.0	-2.0	-1.6	-2.5	-1.3
Heel T-Score	0.0	0.1	0.2	-0.4	-0.2	-0.5	-0.5	0.1
BMI	0.5	2.9	4.1	2.0	-1.5	-1.8	-1.4	-1.6
Height	0.3	6.3	9.0	2.2	-3.0	-2.3	-2.7	-2.2
Waist Hip Ratio (WHR)	0.1	0.4	0.7	0.5	-0.8	-0.5	0.2	-0.8
Systolic Blood Pressure	0.6	3.1	4.6	-1.9	1.2	2.1	1.2	2.1
Smoking Status	0.2	0.4	0.9	-1.0	0.5	0.2	-0.7	0.5
Allergy or Eczema	0.3	0.8	2.1	1.0	-0.4	-1.4	0.1	-1.0
Cardiovascular Disease	0.1	0.3	0.6	0.8	0.0	0.1	0.7	-0.7
Hypothyroidism (self reported)	0.7	1.6	4.7	-2.2	0.9	1.0	-0.4	1.0
Respiratory disease	0.4	0.8	1.7	0.9	-0.3	-1.1	0.4	-1.3
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.4	-0.1	0.2	-0.4	-0.1
Lung FEV1/FVC ratio	0.1	0.4	1.0	-1.0	0.3	0.3	-0.5	0.7
Lung FVC	0.6	3.0	3.8	-1.7	1.6	1.9	1.4	1.9
Neuroticism	13.4	32.4	45.2	-5.4	6.7	5.5	5.7	5.0
Chronotype (morning person)	1.1	2.4	4.0	-0.8	2.0	1.6	1.2	1.9
Hair Pigment	0.0	1.4	2.7	0.9	-1.4	-0.5	-1.6	-1.0
Tanning	0.0	0.1	0.2	-0.3	-0.5	-0.3	-0.3	-0.0
Hand grip strength (left)	1.3	3.4	9.4	1.5	-2.0	-0.9	-3.1	-0.7
Number of treatments/medications taken	0.6	1.1	2.2	-0.7	1.5	0.8	1.1	0.9
Average weekly spirits intake	0.5	0.7	1.5	1.1	-0.2	-0.7	0.4	-1.2
Sensitivity / hurt feelings	7.9	13.6	18.7	-3.5	4.3	3.4	3.8	3.3
Frequency of depressed mood in last 2 weeks	10.3	14.4	18.1	-3.7	4.3	4.0	3.4	3.5
Hearing difficulty/problems: Yes	0.8	1.3	1.9	-1.1	1.4	0.9	1.4	0.8
Relative age of first facial hair	0.0	0.1	0.2	-0.4	0.2	-0.1	0.4	0.0
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	2.6	-1.1	1.5	1.6	1.3	1.5
Ever used hormone-replacement therapy (HRT)	1.7	2.1	3.2	-1.2	1.4	1.3	1.6	1.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.7	-0.2	0.6	-0.3	0.1
Systolic blood pressure, automated reading	0.9	2.6	4.1	-2.0	1.3	1.4	1.1	2.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.1	0.1	-0.3	0.4	-0.4
Angina	1.6	2.1	2.5	-1.6	1.6	1.4	1.1	1.5
Medication for hormone replacement therapy	0.7	0.8	2.6	-0.5	0.7	0.6	-0.3	1.6
Vitamin and mineral supplements	1.3	1.8	3.1	1.4	-1.4	-1.1	-1.8	-1.0
Supplements: Zinc	0.9	1.0	2.1	1.0	-0.9	-1.5	-0.4	-0.8
Medication: Co-codamol	0.3	0.4	1.1	-0.0	0.8	-0.3	1.1	0.0
Medication: Metformin	0.4	0.6	1.0	0.8	-0.8	-1.0	0.1	-0.9
Diabetes (father)	0.7	0.9	1.5	-0.5	1.0	1.2	1.0	0.8
Diabetes (mother)	2.8	3.6	4.5	2.0	-2.1	-1.8	-2.1	-1.4
Severe depression (siblings)	0.4	0.4	1.8	-0.0	0.4	-0.5	1.4	-0.0
Pack years adult smoking proportion	0.3	0.5	1.6	0.4	-0.9	0.1	-1.2	-0.3
Impedance of leg (right)	0.3	1.6	3.0	1.4	-1.7	-1.1	-1.3	-0.5
Leg fat-free mass (left)	0.1	0.8	2.0	0.8	-0.7	-0.6	-1.4	-0.7
Trunk fat percentage	1.4	5.6	9.8	2.2	-2.8	-1.7	-3.1	-1.5
Hand grip strength (right)	0.4	1.1	4.4	0.6	-0.9	-0.2	-2.1	0.1
Townsend deprivation index at recruitment	1.9	2.6	4.3	-2.1	1.4	1.4	1.3	1.8
Current tobacco smoking	0.5	0.9	1.9	-1.4	1.3	0.6	0.1	0.7
Average weekly fortified wine intake	0.5	0.5	0.7	-0.8	0.8	0.5	0.6	0.8
Maternal smoking around birth	0.1	0.1	0.3	-0.4	0.6	0.2	0.3	-0.1
Fed-up feelings	6.1	11.0	14.1	-3.3	3.7	3.7	2.6	3.2
Frequency of unenthusiasm / disinterest in last 2 weeks	9.3	12.4	17.2	-4.2	3.5	3.7	2.4	3.6
Relative age voice broke	0.1	0.2	0.3	0.4	-0.6	-0.3	-0.5	-0.1
Taking other prescription medications	2.2	3.4	5.6	-1.1	2.4	1.5	2.4	1.6
Age when periods started (menarche)	0.0	0.0	0.1	0.0	0.2	0.3	-0.1	0.3
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.5	-2.1	1.4	1.7	0.6	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.3	-1.1	0.8	0.5	0.5	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.2	-0.2	-0.9	-1.1	-0.3
Qualifications: CSEs or equivalent	1.5	2.0	3.0	1.7	-1.6	-0.9	-0.9	-1.7
Serious illness, injury or assault to yourself	1.0	1.3	2.0	1.3	-1.4	-0.8	-0.6	-1.2
High blood pressure	0.1	0.3	1.0	0.4	0.3	0.3	1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.6	1.6	-0.7	-1.4	0.3	-1.3
Multivitamins +/- minerals	0.4	0.5	2.2	0.3	0.2	0.2	1.5	-0.0
Stomach or abdominal pain in last month	1.5	1.9	3.6	-1.3	1.7	0.9	1.9	0.6
Supplements: Glucosamine	0.4	0.6	1.5	-0.5	0.7	-0.2	1.2	-0.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.3	1.1	-1.2	-0.8	-1.5	-1.3
Medication: Atenolol	1.2	1.5	2.3	-1.4	1.0	1.5	0.0	1.4
Medication: Levothyroxine sodium	2.4	4.1	10.2	-3.2	1.7	1.7	1.2	1.7
Sitting height	0.0	0.0	0.1	-0.1	0.1	0.3	0.1	-0.2
Chronic bronchitis/emphysema (father)	3.0	3.5	5.8	1.5	-2.3	-1.9	-2.4	-0.8
High blood pressure (mother)	0.2	0.2	0.4	-0.0	-0.5	-0.7	-0.4	-0.6
Body mass index (BMI)	0.3	1.1	2.1	1.0	-0.9	-0.8	-1.4	-0.9
Impedance of leg (left)	0.2	0.7	1.6	1.0	-1.3	-0.6	-0.8	-0.2
Leg predicted mass (left)	0.1	0.7	1.9	0.7	-0.6	-0.6	-1.4	-0.7
Trunk fat mass	1.2	5.1	9.9	2.0	-2.5	-1.6	-3.1	-1.4
Waist circumference	0.1	0.5	0.7	0.6	-0.9	-0.3	-0.8	-0.6
Number of incorrect matches in round	0.5	0.8	1.6	0.6	-1.0	-1.2	-0.8	-0.6
Past tobacco smoking	0.1	0.2	0.3	0.4	0.3	0.6	0.4	-0.3
Alcohol usually taken with meals	0.8	1.3	2.6	1.4	-0.7	-1.6	0.3	-1.2
Nervous feelings	2.1	3.9	5.7	-1.9	2.2	1.9	2.4	1.4
Frequency of tenseness / restlessness in last 2 weeks	4.0	6.3	9.1	-3.0	2.9	2.7	1.2	2.4
Hearing difficulty/problems with background noise	4.9	7.9	13.4	-2.3	3.2	2.5	3.7	1.9
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	-0.6	1.2	0.4	0.7	0.5
Had menopause	0.1	0.2	0.5	-0.7	0.2	0.2	-0.0	0.5
Had other major operations	0.3	0.3	0.8	0.9	-0.5	-0.4	-0.3	-0.6
Forced vital capacity (FVC)	0.1	0.4	0.9	-0.7	0.0	0.7	-0.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.0	0.0	0.2	0.6	-0.0
Qualifications: None of the above	0.3	0.6	1.3	-0.7	0.5	1.1	-0.6	0.8
Financial difficulties in last 2 years	0.7	1.0	1.5	-0.6	1.2	0.9	1.2	0.9
Mouth/teeth dental problems	2.1	3.3	5.3	1.9	-2.3	-1.5	-1.7	-1.6
Heart attack	0.4	0.5	1.7	-0.1	0.0	0.7	-1.3	0.4
Allergy	0.6	1.4	2.2	-1.4	0.6	1.5	0.7	1.4
Pain all over the body in last month	1.5	1.6	2.3	-1.5	1.5	1.1	1.0	1.1
Diabetes (self-reported)	0.2	0.2	0.4	-0.6	0.1	0.6	0.6	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-0.7	0.5	0.2	1.0	-0.1
Medication: Ramipril	0.5	0.6	1.3	-0.7	0.6	1.0	0.2	1.2
Medication: Simvastatin	0.2	0.3	1.2	0.0	0.5	0.2	1.1	-0.3
Fluid intelligence score	0.5	0.9	3.0	0.1	1.2	0.3	1.7	-0.5
Illnesses of siblings	0.2	0.3	0.9	0.0	0.3	-0.9	-0.7	-0.5
Neuroticism score	5.9	12.4	18.0	-3.4	4.2	3.4	3.6	2.8
Weight	0.5	2.5	4.7	1.4	-1.6	-1.3	-2.2	-1.3
Impedance of arm (right)	1.6	7.4	13.9	2.5	-3.7	-2.2	-3.0	-1.7
Arm fat percentage (right)	1.8	7.2	12.6	2.5	-3.1	-2.1	-3.6	-1.8
Trunk fat-free mass	0.0	0.2	0.5	0.3	-0.2	-0.4	-0.7	-0.6
Hip circumference	0.1	0.4	1.2	0.6	-0.6	-0.4	-1.1	-0.3
Time employed in main current job	0.1	0.1	0.5	0.7	-0.2	-0.2	0.2	-0.1
Alcohol intake versus 10 years previously	0.6	0.8	3.0	-0.6	-0.3	0.2	-1.7	0.8
Father’s age at death	0.1	0.2	0.5	-0.7	0.3	0.3	0.1	0.4
Worrier / anxious feelings	2.8	5.2	9.7	-2.2	3.1	2.0	2.0	1.8
Frequency of tiredness / lethargy in last 2 weeks	7.5	12.2	14.9	-3.9	3.8	3.8	2.5	3.2
Falls in the last year	0.3	0.4	1.6	0.0	0.6	0.4	1.2	0.2
Hair/balding pattern: Pattern 3	1.9	2.8	3.5	-1.5	1.6	1.4	1.8	1.9
Number of live births	1.7	2.4	4.3	1.2	-1.6	-2.1	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	-0.6	0.1	0.7	-0.8	1.1
Pulse rate	0.1	0.2	0.7	-0.2	-0.3	-0.1	-0.8	-0.3
Happiness	0.3	0.3	0.9	0.3	-0.5	-0.5	-0.9	-0.2
Noisy workplace	0.3	0.4	0.7	-0.7	0.8	0.8	0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	0.7	-0.0	0.2	1.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.5	-0.1	0.1	-0.3	0.1
Mouth/teeth dental problems: Dentures	2.7	4.6	6.3	-2.5	2.4	2.3	0.8	2.3
Asthma	0.5	1.0	2.3	1.1	-0.2	-1.1	-0.2	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.7	-1.1	-0.2	-1.0	-0.3
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.0	0.2	-0.1	0.3	-0.5
Depression (self-reported)	1.5	1.8	2.5	-1.6	1.3	1.5	1.3	1.1
Medication: Lansoprazole	0.4	0.4	1.1	0.9	0.1	-0.5	-0.4	-1.1
Prospective memory result	0.2	0.2	0.5	0.0	0.1	0.6	0.1	0.7
Lung cancer (father)	1.7	2.0	2.7	-1.6	1.2	1.4	1.2	1.6
Illnesses of mother	0.1	0.1	0.2	0.1	0.5	0.4	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	-0.4	0.2	0.4	-0.6	0.7
Pulse wave Arterial Stiffness index	4.7	5.5	7.4	-2.4	2.5	2.3	2.7	1.8
Impedance of arm (left)	1.6	7.2	13.4	2.5	-3.7	-2.2	-3.0	-1.6
Arm fat mass (right)	1.0	4.0	7.0	1.9	-2.2	-1.5	-2.6	-1.6
Trunk predicted mass	0.0	0.2	0.4	0.3	-0.2	-0.4	-0.6	-0.6
Standing height	0.2	2.4	3.6	1.3	-1.8	-1.3	-1.9	-1.2
Length of working week for main job	0.6	0.6	1.3	-0.8	1.1	1.0	-0.2	0.4
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.3	-0.2	0.2	-0.9	-0.3
Breastfed as a baby	0.4	0.5	1.0	1.0	-0.7	-0.4	0.3	-1.0
Tense / ‘highly strung’	0.4	0.7	1.2	-0.7	1.1	0.7	-0.3	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.5	5.4	13.3	-1.1	2.5	1.8	3.7	1.6
Hair/balding pattern: Pattern 4	0.7	1.8	2.3	-1.5	1.4	1.2	1.0	1.5
Birth weight of first child	0.3	0.5	1.3	0.3	-0.7	-0.7	-1.1	-0.6
Peak expiratory flow (PEF)	0.1	0.3	0.7	0.7	-0.4	-0.2	-0.8	0.2
Pulse wave reflection index	1.5	1.9	2.2	-1.4	1.3	1.5	1.4	1.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.0	-0.4	1.0	0.2	0.3	-0.1
Loud music exposure frequency	0.9	1.0	2.1	-1.1	0.3	0.7	-1.4	1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	1.0	-0.7	-0.6	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.5	-0.5	1.5	0.9	1.6	0.6
Blood clot in the leg (DVT)	0.1	0.1	0.5	0.7	-0.2	0.2	-0.4	-0.2
Medication: Paracetamol	0.6	0.9	3.2	0.7	-0.9	-0.2	-1.8	-0.3
Headache pain in last month	0.3	0.6	0.9	-0.9	0.7	0.9	0.9	0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.1	-0.4	0.0	-0.7	0.4
Glaucoma (self-reported)	1.5	1.8	5.8	-0.8	1.0	1.1	2.4	0.6
Gout (self-reported)	3.1	4.3	7.5	-2.7	2.0	1.8	0.1	2.7
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	6.0	-2.5	1.2	1.2	0.3	1.1
Medication: Amlodipine	0.8	1.1	1.9	1.0	-0.9	-1.3	0.5	-1.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	-0.4	0.5	-0.0	0.4	-0.5
Birth weight	0.9	1.9	4.6	0.4	-2.1	-1.3	-1.8	-0.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-0.6	0.6	0.7	0.2	1.0
High blood pressure (siblings)	0.4	0.6	2.0	0.6	-1.4	0.1	-0.8	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.2	0.4	-0.3	0.0	0.5	-0.4	0.6
Body fat percentage	1.3	5.2	9.8	2.2	-2.6	-1.7	-3.1	-1.4
Leg fat percentage (right)	0.8	2.9	5.9	1.6	-1.9	-1.2	-2.4	-0.9
Arm fat-free mass (right)	0.0	0.2	0.8	-0.4	0.9	0.3	-0.2	0.3
Exposure to tobacco smoke outside home	1.9	2.5	4.8	-1.8	2.2	1.5	0.8	1.2
Comparative body size at age 10	1.0	2.7	4.1	1.9	-1.6	-2.0	-0.7	-1.7
Number of full brothers	1.3	1.7	4.3	-0.5	0.9	1.7	2.1	0.5
Worry too long after embarrassment	6.5	10.9	20.4	-2.8	3.5	3.1	4.5	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	5.3	-0.2	0.4	0.9	2.3	0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.0	0.6	-0.4	0.1	-0.4
Number of children fathered	0.3	0.4	1.2	-0.3	0.1	0.7	-0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.3	0.1	-0.0	0.4	-0.1
Age at first live birth	2.4	4.2	8.3	2.6	-1.4	-1.9	-0.5	-2.9
Pulse wave peak to peak time	4.9	5.8	8.1	2.4	-2.6	-2.3	-2.8	-1.7
Health satisfaction	0.0	0.1	0.1	0.0	0.2	-0.4	-0.2	-0.3
Shortness of breath walking on level ground	2.5	3.0	4.2	-2.0	1.8	1.8	0.6	1.9
Qualifications: College or University degree	0.4	1.2	2.6	1.6	-0.9	-0.9	0.7	-1.2
Eye problems/disorders: None of the above	1.9	2.2	3.1	-1.7	1.3	1.8	0.7	1.6
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	-1.0	0.1	0.3	-0.6	0.1
Emphysema/chronic bronchitis	1.2	1.3	1.9	-1.4	1.2	0.5	1.3	1.2
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	-1.1	1.1	0.5	1.1	0.3
Neck or shoulder pain in last month	1.7	2.4	3.1	-1.4	1.8	1.5	1.7	1.4
Medication: Blood pressure	0.0	0.1	0.2	-0.4	0.2	0.1	0.1	-0.0
Angina (self-reported)	1.5	2.0	2.5	-1.4	1.5	1.4	1.1	1.6
Migraine (self-reported)	5.8	7.2	11.1	3.3	-2.6	-2.8	-1.7	-2.8
Medication: Ibuprofen	0.1	0.1	0.3	-0.3	-0.0	0.5	0.3	0.5
Medication: Allopurinol	0.5	0.6	1.5	-1.2	0.7	0.4	-0.1	0.9
Medication: Omeprazole	1.4	1.7	6.2	0.5	1.4	0.5	2.5	0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.6	0.2	-0.1	0.7	-0.1
Mean time to correctly identify matches	2.0	3.7	7.2	-1.5	2.0	1.7	2.7	1.5
Heart disease (mother)	0.2	0.2	0.8	-0.1	0.6	-0.0	0.9	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.2	-1.1	0.4	0.5	0.1	0.3
Whole body fat mass	1.1	4.5	9.1	1.9	-2.3	-1.6	-3.0	-1.4
Leg fat mass (right)	0.7	2.6	5.9	1.4	-1.7	-1.1	-2.4	-0.9
Arm predicted mass (right)	0.0	0.2	0.5	-0.2	0.7	0.2	-0.3	0.2
Pulse rate, automated reading	0.1	0.3	0.7	0.8	-0.2	-0.3	-0.1	-0.9
Alcohol intake frequency.	0.6	1.4	4.1	0.2	-0.8	-1.3	-2.0	-0.4
Comparative height size at age 10	0.6	3.0	5.2	1.5	-2.3	-1.2	-2.1	-1.3
Number of full sisters	0.7	0.9	2.5	-0.7	0.8	0.8	-0.0	1.6
Suffer from ‘nerves’	5.0	7.8	9.7	-3.0	3.1	3.1	2.5	2.1
Overall health rating	2.2	4.7	8.0	-2.3	2.8	2.3	1.6	1.6
Chest pain or discomfort	3.3	4.8	7.8	-2.0	2.8	1.8	2.4	1.8
Had major operations	2.5	3.0	3.8	1.7	-1.9	-1.7	-1.4	-1.8
Age at last live birth	2.6	3.7	5.7	2.2	-1.6	-1.9	-1.3	-2.4
Family relationship satisfaction	0.8	1.0	2.6	-0.7	1.0	0.5	1.6	0.7
Leg pain on walking	0.1	0.1	0.3	-0.0	-0.2	-0.0	0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.1	0.0	-0.3	-0.5	-1.8	0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.4	-1.1	0.9	0.8	-0.7	1.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.7	0.1	-0.8	0.1	-0.3
Medication: Aspirin	0.2	0.2	0.4	0.3	-0.6	-0.2	-0.5	-0.5
Supplements: Vitamin C	0.3	0.4	0.8	-0.9	0.5	0.4	0.7	0.3
Knee pain experienced in last month	1.5	2.3	3.6	-1.6	1.9	1.3	1.5	1.2
Hypertension (Self-reported)	0.0	0.1	0.4	0.3	0.1	0.2	0.6	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.3	0.9	0.6	0.2	1.1	-0.3
Illnesses of father: Heart disease	1.8	2.4	3.6	1.9	-1.9	-0.9	-1.3	-1.6
Illnesses of siblings: Diabetes	0.7	0.8	3.3	0.2	0.2	0.6	1.8	0.6
Smoking status: Previous	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	0.2	-0.2	-0.1	-0.9	-0.4
Whole body fat-free mass	0.0	0.3	0.8	0.4	-0.2	-0.4	-0.9	-0.5
Leg fat-free mass (right)	0.1	0.3	1.1	0.4	-0.2	-0.3	-1.0	-0.4
Arm fat percentage (left)	1.6	6.3	11.7	2.4	-2.8	-1.9	-3.4	-1.6
Average weekly red wine intake	0.8	1.2	3.2	1.3	-0.9	-1.8	0.2	-0.8
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.8	0.8	-1.3	-0.9	-0.7	-1.0
Mood swings	2.9	5.3	6.8	-2.1	2.6	2.4	2.4	1.9
Loneliness, isolation	10.8	14.9	18.4	-4.0	4.3	3.9	3.2	3.7
Long-standing illness, disability or infirmity	1.2	1.8	4.4	-0.8	1.6	1.1	2.1	0.5
Ever had bowel cancer screening	0.2	0.3	0.7	-0.2	-0.7	0.0	-0.8	0.3
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.6	-0.2	0.3	-0.0	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.0	-0.1	0.1	0.1	0.2
Friendships satisfaction	0.9	1.1	2.3	-0.7	1.0	0.7	1.5	1.1
Qualifications: nursing, teaching	1.5	2.4	3.9	2.0	-1.6	-1.5	-0.5	-1.8
Commuting to job workplace: Walk	0.0	0.0	0.1	0.0	-0.4	-0.0	0.2	-0.2
Eye problems/disorders: Cataract	0.8	1.0	2.0	1.4	-0.5	-1.1	-0.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	0.9	0.9	-0.5	-0.6	-0.8	-0.9
Medication for cholesterol	0.4	0.7	1.6	-1.3	1.0	0.7	0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.6	-0.1	-0.4	1.0	-0.4
Back pain experienced in last month	0.4	0.6	1.3	-0.4	1.1	0.4	1.1	0.4
Mineral and other dietary supplements	0.4	0.6	1.0	-0.5	0.7	1.0	0.4	1.0
Breast cancer (self-reported)	0.9	1.1	1.7	-0.9	0.1	1.1	-1.3	1.3
Asthma (self-reported)	0.5	1.0	2.6	1.0	-0.2	-1.2	-0.0	-1.6
Osteoporosis (self-reported)	1.1	1.4	2.6	1.4	-0.9	-1.2	-0.1	-1.6
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.8	0.7	-0.2	0.2	-0.2
Medication: Aspirin	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.2	-0.0
Medication: Gliclazide	0.3	0.3	1.3	0.2	0.2	-0.4	1.1	-0.0
Illnesses of father: None of the above (group 1)	1.6	1.9	3.2	-1.4	1.8	1.4	1.2	1.1
Smoking status: Current	0.2	0.4	1.1	-1.0	0.8	0.1	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	2.8	-1.4	1.0	1.4	0.4	1.7
Whole body water mass	0.0	0.2	0.6	0.3	-0.1	-0.3	-0.8	-0.5
Leg predicted mass (right)	0.1	0.3	1.1	0.4	-0.2	-0.3	-1.0	-0.4
Arm fat mass (left)	1.0	4.1	7.9	1.8	-2.2	-1.6	-2.8	-1.4
Number of self-reported non-cancer illnesses	1.2	2.1	4.5	-0.8	1.7	1.3	2.1	0.9
Average weekly champagne plus white wine intake	0.3	0.5	1.1	-0.4	0.8	0.5	1.1	0.5
Miserableness	2.5	4.4	5.6	-1.9	2.4	2.3	2.3	1.4
Guilty feelings	7.3	11.0	14.8	-3.3	3.8	3.4	2.9	3.0
Wears glasses or contact lenses	0.4	0.5	2.0	-0.1	-0.6	-0.1	-1.4	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.2	-0.2	0.1	-0.4	-0.3
Hearing aid user	0.3	0.4	1.5	-0.0	0.4	-0.1	1.2	-0.3
Mother’s age at death	1.7	2.1	3.2	1.7	-1.8	-1.2	-0.9	-1.5
Financial situation satisfaction	2.3	2.8	6.2	1.2	-1.7	-1.4	-2.5	-1.3
Tinnitus: Yes, now most or all of the time	4.0	4.7	7.8	-2.8	2.0	1.6	2.2	2.1
Commuting to job workplace: Public transport	2.7	3.2	4.9	1.9	-2.2	-1.9	-1.2	-1.5
Eye problems/disorders: Glaucoma	0.7	0.8	1.7	-0.6	0.4	1.3	0.9	1.0
Medication: Blood pressure	0.1	0.1	0.3	0.3	0.3	0.4	0.5	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	-0.8	0.8	0.5	0.8	0.4
Supplements: Fish oil (including cod liver oil)	1.3	1.8	3.2	1.2	-1.2	-1.4	-0.7	-1.8
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.0	0.7	-0.1	1.0	-0.9
Medication: Bendroflumethiazide	0.2	0.2	0.6	0.5	0.0	-0.1	0.8	-0.6
Medication: Paracetamol	0.3	0.4	1.7	0.3	-0.4	-0.2	-1.3	0.1
Medication: Lisinopril	0.4	0.5	1.3	1.1	-0.7	-0.1	-0.8	-0.4
Medication: Atorvastatin	0.3	0.4	1.0	-0.7	1.0	0.5	0.5	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.3	-0.4	-0.2	0.6	-1.1	0.7
Alcohol drinker status: Never	0.1	0.1	0.4	-0.0	-0.3	0.2	-0.3	0.6
Ever smoked	0.2	0.3	0.6	-0.4	-0.2	-0.8	-0.8	0.0
Basal metabolic rate	0.1	0.7	1.5	0.7	-0.6	-0.7	-1.2	-0.8
Leg fat percentage (left)	0.5	1.8	4.4	1.2	-1.5	-0.8	-2.1	-0.7
Arm fat-free mass (left)	0.0	0.1	0.2	-0.1	0.5	0.0	-0.3	-0.1
Number of operations (self-reported)	0.2	0.3	0.4	-0.6	0.7	0.6	0.1	0.6
Average weekly beer plus cider intake	1.9	2.7	3.5	-1.3	1.6	1.9	1.8	1.6
Irritability	2.6	4.4	8.1	-1.8	2.8	1.7	2.4	1.4
Risk taking	0.3	0.4	1.0	0.6	-0.5	-0.7	-1.0	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.2	-0.1	-0.4	0.4	1.1	0.3
Fractured/broken bones in last 5 years	1.7	2.2	3.0	-1.7	1.5	1.6	1.2	1.5
Age started oral contraceptive pill	1.8	2.2	3.0	1.3	-1.6	-1.6	-1.2	-1.7
Diastolic blood pressure, automated reading	1.6	5.1	7.3	-2.1	2.0	2.7	1.9	2.5
Ever depressed for a whole week	1.6	1.9	3.7	-1.1	1.7	1.1	1.9	0.8
Unable to work because of sickness or disability	0.5	0.6	1.7	-0.8	1.3	0.4	0.6	0.2
Commuting to job workplace: Cycle	0.6	0.8	2.2	-0.6	0.9	0.5	1.5	0.3
Myopia	0.2	0.2	0.5	-0.1	0.4	0.4	0.5	0.7
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.6	0.2	-1.0	-1.0	-1.6	-0.4
Cholesterol lowering medication	0.6	0.9	3.6	0.4	0.8	-0.1	1.9	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	6.8	0.4	1.4	0.5	2.6	0.1
Pain experienced in last month	1.6	2.6	4.3	1.6	-2.1	-1.2	-1.6	-1.4
Supplements: Calcium	0.1	0.1	0.2	-0.2	-0.1	-0.2	0.2	-0.4
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	0.8	-0.7	-1.3	-0.6	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.9	-0.4	0.2	0.9	-1.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.5	-0.2	0.2	-0.2	-0.2
Heart disease (siblings)	3.2	3.9	5.7	-1.9	1.8	2.4	1.8	1.9
Alcohol drinker status: Previous	0.5	0.5	1.0	-0.9	1.0	0.5	0.4	0.7
Pack years of smoking	0.3	0.5	1.3	0.2	-0.9	0.3	-1.2	-0.3
Impedance of whole body	0.7	3.7	6.7	1.9	-2.6	-1.6	-2.1	-1.0
Leg fat mass (left)	0.5	1.9	4.8	1.1	-1.4	-0.8	-2.2	-0.7
Arm predicted mass (left)	0.0	0.1	0.2	-0.1	0.5	-0.0	-0.3	-0.1