Hub : Genes

SUN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.106	0.0374	0.00030	0.052	NA	0.058	NA	0.079	6.3e-05	NA	2.3e-05	NA	8.9e-07
2	GTEx	Brain Cerebellum	0.150	0.0680	0.00850	-0.004	NA	0.021	NA	-0.003	4.3e-01	NA	7.7e-02	NA	4.0e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.273	0.0990	0.00140	-0.003	NA	-0.009	NA	-0.004	4.1e-01	NA	9.9e-01	NA	4.8e-01
4	GTEx	Thyroid	0.076	0.0300	0.00220	0.056	NA	0.056	NA	0.054	4.1e-05	NA	4.3e-05	NA	5.7e-05
5	TCGA	Thyroid Carcinoma	0.059	0.0270	0.00037	0.045	0.043	0.044	NA	0.040	2.9e-05	4.4e-05	3.8e-05	NA	8.8e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.0	3.2	12.1	-3.5	-0.7	1.0	1.5	0.3
Bipolar Disorder or Schizophrenia	2.9	7.0	19.6	-4.4	-1.0	2.0	3.1	0.5
Depressed Affect (Nagel 2018)	1.8	3.7	10.0	0.3	1.4	-3.2	-2.4	1.0
Depression (Nagel 2018)	3.1	4.7	9.5	1.4	2.4	-2.2	-3.1	-1.1
Intelligence (Savage-Jansen 2018)	0.8	2.5	6.8	-1.3	-0.7	1.1	2.6	1.5
Neuroticism (Nagel 2018)	0.5	1.2	4.0	-0.6	0.7	-2.0	-0.5	0.9
Schizophrenia (2018)	1.9	4.0	8.2	-2.9	-0.8	1.8	2.8	0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.4	0.3	0.0	-0.3	-0.1
Worry (Nagel 2018)	0.1	0.3	0.8	-0.3	0.7	0.1	0.9	0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	1.3	-0.2	0.1	0.5	1.0
Alzheimer’s Disease (in father)	1.0	1.1	2.7	0.0	-1.6	1.5	0.6	0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	0.7	-0.4	1.1	0.5	0.5
Crohns Disease (2017)	0.5	1.0	2.9	-0.4	1.7	-0.1	-1.2	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.5	0.1	0.7	0.2	-0.3	-1.2
Ulcerative Colitis (UC)	0.1	0.2	0.6	0.3	0.0	-0.1	0.5	-0.8
Major Depression (MDD)	1.0	1.2	6.0	0.0	0.0	0.0	0.0	-2.5
Reaction Time	1.7	3.3	7.3	2.7	2.1	-0.1	-0.5	-2.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.2	-1.9	0.3	0.8	2.3	0.7
Breast Cancer	0.6	1.4	3.9	1.1	0.9	-0.6	-2.0	0.7
Ovarian Cancer	0.7	1.0	3.8	0.9	-0.3	0.2	0.2	1.9
Prostate Cancer	0.5	0.7	1.4	1.0	0.8	0.8	0.0	1.2
Age at First Birth	2.4	3.4	8.4	-1.2	-0.9	2.9	2.1	-1.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.3	0.0	0.0	0.0	0.0	-0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	0.4	-0.6	0.2	0.5	-0.1	0.0
Mean Putamen Volume	0.5	0.5	1.2	-0.8	-0.7	0.7	-0.2	1.1
Fasting Glucose	0.7	0.9	1.8	-0.9	-0.2	1.2	1.4	0.3
HbA1C	2.6	2.9	5.4	0.7	2.3	-1.8	-2.3	-0.5
HDL Cholesterol	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.4
LDL Cholesterol	0.2	0.3	1.5	0.0	0.0	0.0	0.0	1.2
Lupus	1.7	2.6	4.9	1.8	1.5	-1.3	-2.2	-0.9
Neuroticism (2016)	0.9	1.3	2.9	0.7	0.9	-1.2	-1.7	1.0
Primary Biliary Cirrhosis	0.4	0.6	1.5	0.3	1.2	-0.1	-1.2	-0.2
Rheumatoid Arthritis	1.9	2.6	6.8	2.6	1.0	-0.9	-2.0	-0.6
Schizophrenia (2014)	1.1	2.4	7.1	-2.7	-0.6	1.1	1.7	0.8
Triglycerides	0.2	0.3	1.6	0.0	0.0	0.0	0.0	1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.3	0.0	0.0	0.0	0.0	-1.5
Ulcerative Colitis	0.4	0.5	1.2	0.1	-0.0	0.7	1.1	-1.0
Blood Eosinophil Count	1.3	10.1	19.8	0.3	4.0	-3.6	-4.5	1.2
Blood Platelet Count	0.9	11.0	13.7	3.6	-3.7	3.7	3.4	-1.5
Blood Red Count	0.3	3.0	9.4	3.1	-0.9	2.1	0.1	-0.6
Blood White Count	0.3	2.1	4.0	2.0	1.8	0.5	-1.6	0.4
Heel T-Score	0.2	1.4	5.3	0.9	-0.8	0.2	-0.2	-2.3
BMI	1.5	8.9	21.2	3.3	0.5	-3.5	-4.6	-0.3
Height	0.6	10.7	19.4	-4.4	-3.7	2.3	3.9	0.2
Waist Hip Ratio (WHR)	0.1	0.5	1.5	0.7	-0.9	1.2	0.2	0.0
Systolic Blood Pressure	0.3	1.7	4.4	-0.4	1.4	-0.4	-1.4	2.1
Smoking Status	0.9	2.2	4.0	0.2	2.0	-1.4	-1.8	1.4
Allergy or Eczema	0.3	0.8	1.2	-0.8	1.1	-0.9	-1.1	-0.3
Cardiovascular Disease	1.1	3.7	11.4	-0.4	0.7	-0.6	-2.5	3.4
Hypothyroidism (self reported)	0.4	0.9	1.8	1.4	-0.9	-0.3	-1.3	0.3
Respiratory disease	0.9	2.0	6.9	0.7	1.5	-0.3	-2.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.5	-0.5	-1.2	1.2	1.2	-0.7
Lung FEV1/FVC ratio	1.4	7.0	14.0	-1.9	-0.2	-2.7	-3.2	3.7
Lung FVC	1.2	6.4	19.6	-1.9	-2.2	1.9	4.4	-0.5
Neuroticism	1.3	3.2	6.3	-0.5	1.1	-2.5	-1.5	2.5
Chronotype (morning person)	1.1	2.4	3.8	-0.7	-1.4	1.9	1.9	-1.6
Hair Pigment	0.1	3.8	10.5	0.5	-3.2	1.3	2.1	-1.4
Tanning	0.1	1.1	3.7	1.9	0.8	-0.7	-0.7	0.1
Hand grip strength (left)	1.1	2.8	5.6	-1.2	-2.4	-1.9	-0.9	1.6
Number of treatments/medications taken	0.3	0.5	1.9	0.2	-0.2	0.0	-1.4	0.6
Average weekly spirits intake	1.3	1.6	5.0	0.6	0.4	-0.7	-2.2	-1.4
Sensitivity / hurt feelings	0.2	0.4	1.5	0.2	1.2	-0.4	-0.5	-0.3
Frequency of depressed mood in last 2 weeks	1.5	2.0	3.9	1.6	1.4	-1.3	-2.0	-0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.6	-0.8	-0.5	0.1	0.4	-0.2
Relative age of first facial hair	0.2	0.5	1.3	-0.3	0.4	0.8	-0.2	-1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	-0.5	1.0	0.5	-0.4	-1.5
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.2	0.0	-1.1	1.8	1.3	-0.6
Ever had hysterectomy (womb removed)	0.8	0.9	2.7	1.6	0.0	0.3	-0.3	-1.2
Systolic blood pressure, automated reading	0.8	2.2	5.0	1.0	2.2	-0.8	-2.1	0.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	4.6	0.4	1.1	-0.1	-0.4	-2.1
Angina	0.3	0.4	1.5	0.5	0.4	-0.3	0.0	1.2
Medication for hormone replacement therapy	1.2	1.4	4.5	-0.4	0.9	-2.1	-1.1	0.4
Vitamin and mineral supplements	1.0	1.3	3.3	-0.2	-0.5	0.9	1.8	-1.5
Supplements: Zinc	1.9	2.1	5.7	0.2	1.2	-1.7	-2.4	0.3
Medication: Co-codamol	0.2	0.2	0.6	-0.6	0.1	0.8	-0.1	-0.2
Medication: Metformin	0.1	0.1	0.2	-0.2	0.0	-0.4	0.4	-0.1
Diabetes (father)	0.4	0.5	1.8	-0.4	-0.5	-1.3	-0.3	-0.1
Diabetes (mother)	0.4	0.5	1.6	0.3	1.3	0.5	-0.0	-0.6
Severe depression (siblings)	2.8	3.1	6.4	-2.1	-1.2	-0.8	1.7	2.5
Pack years adult smoking proportion	0.3	0.4	0.8	0.9	0.4	0.1	0.8	0.7
Impedance of leg (right)	2.0	9.7	22.4	-1.8	-3.3	4.7	3.1	1.5
Leg fat-free mass (left)	0.9	4.6	15.1	0.6	0.6	-3.9	-2.6	0.3
Trunk fat percentage	0.7	3.0	6.9	1.8	-2.6	1.5	-1.0	-1.1
Hand grip strength (right)	0.7	1.9	3.0	-1.1	-1.5	-1.7	-0.9	1.4
Townsend deprivation index at recruitment	0.6	0.9	2.3	-0.1	0.2	-0.8	-1.5	1.2
Current tobacco smoking	1.4	2.2	3.6	-1.3	1.7	-1.9	-0.5	1.6
Average weekly fortified wine intake	0.7	0.8	1.4	-1.0	0.6	-1.2	-0.4	1.0
Maternal smoking around birth	1.6	2.4	5.6	0.3	1.4	-2.4	-1.8	0.9
Fed-up feelings	2.5	4.6	7.6	1.2	1.3	-2.6	-2.3	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	6.0	1.4	1.5	-1.6	-2.4	-0.2
Relative age voice broke	0.9	1.3	6.0	-2.4	0.2	0.4	-0.3	-0.5
Taking other prescription medications	0.2	0.3	1.0	0.1	0.2	-0.5	-1.0	0.5
Age when periods started (menarche)	0.2	0.4	0.8	-0.8	0.9	-0.7	-0.3	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.9	0.0	0.2	-0.9	-0.4	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	5.0	0.3	0.2	1.1	0.1	-2.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.2	-0.4	0.4	0.7	0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.6	-0.4	0.0	-1.3	0.1	-0.2
Serious illness, injury or assault to yourself	1.1	1.3	2.9	-1.6	-0.1	-1.7	-1.0	0.4
High blood pressure	0.7	2.0	6.1	0.2	1.3	-0.6	-2.5	1.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.2	-0.5	0.2	-0.9	-1.1	0.3
Multivitamins +/- minerals	2.0	2.5	6.5	0.1	0.5	-1.8	-2.5	1.6
Stomach or abdominal pain in last month	2.1	2.6	7.5	-0.7	0.7	-2.7	-1.5	1.5
Supplements: Glucosamine	0.5	0.6	1.3	-1.1	0.0	-0.8	-0.1	1.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.3	0.5	-0.8	-0.7	0.6
Medication: Atenolol	0.2	0.3	0.5	0.6	-0.1	-0.5	-0.7	0.7
Medication: Levothyroxine sodium	1.0	1.6	4.0	0.3	0.3	0.2	-2.0	-2.0
Sitting height	0.1	0.8	2.9	-0.9	-1.7	0.1	0.4	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.5	0.8	0.2	-0.2	-0.0
High blood pressure (mother)	0.3	0.4	1.2	-0.3	-0.4	-0.4	-0.5	1.1
Body mass index (BMI)	1.4	5.8	14.7	2.5	0.9	-2.6	-3.8	-0.7
Impedance of leg (left)	2.1	10.0	24.4	-1.7	-3.3	4.9	3.4	0.8
Leg predicted mass (left)	0.8	4.5	14.7	0.5	0.7	-3.8	-2.6	0.4
Trunk fat mass	0.5	2.1	3.6	1.6	-1.9	0.1	-1.7	-1.0
Waist circumference	0.8	2.9	7.6	2.0	0.2	-1.3	-2.8	-1.1
Number of incorrect matches in round	0.1	0.1	0.2	-0.5	-0.3	0.0	-0.2	-0.3
Past tobacco smoking	0.3	0.5	2.2	-0.2	-1.5	-0.4	0.3	-0.2
Alcohol usually taken with meals	1.5	2.5	9.4	0.5	-1.1	1.1	0.5	-3.1
Nervous feelings	0.2	0.3	1.0	0.2	0.5	0.2	1.0	0.5
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	7.4	0.1	1.6	-2.7	-1.9	1.3
Hearing difficulty/problems with background noise	0.9	1.4	3.8	-2.0	0.8	-1.5	0.4	0.1
Hair/balding pattern: Pattern 2	0.9	1.1	4.4	0.1	0.1	-1.1	-0.4	2.1
Had menopause	2.5	3.1	8.2	-0.1	-1.3	2.9	1.9	-1.3
Had other major operations	0.7	0.8	1.9	1.4	0.4	-0.2	-0.8	-1.1
Forced vital capacity (FVC)	1.6	6.1	13.9	-3.1	-2.4	0.9	3.7	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	8.4	0.2	0.4	1.0	0.7	-2.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.3	-1.8	1.0	1.0	1.2	0.5
Qualifications: None of the above	0.8	1.7	2.9	1.5	1.7	-0.2	-1.3	-1.3
Financial difficulties in last 2 years	1.5	2.0	3.8	-1.9	-1.2	-1.9	-0.7	1.0
Mouth/teeth dental problems	1.2	1.8	5.6	-0.5	-0.8	2.4	1.4	-0.9
Heart attack	0.3	0.3	1.3	0.3	0.4	-1.1	0.1	0.5
Allergy	0.2	0.5	1.5	-0.2	-0.7	0.5	1.2	0.2
Pain all over the body in last month	0.2	0.2	0.5	0.7	-0.2	-0.0	0.4	0.6
Diabetes (self-reported)	0.7	1.1	3.0	0.4	-0.7	1.0	1.0	-1.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.0	-1.0	0.9	-0.6	-0.9	-0.4
Medication: Ramipril	0.3	0.4	1.2	-1.1	0.1	-0.4	-0.8	0.2
Medication: Simvastatin	0.8	1.2	3.3	0.5	1.8	-1.3	-0.8	0.3
Fluid intelligence score	0.8	1.7	5.3	-0.9	-1.0	1.0	2.3	0.6
Illnesses of siblings	0.1	0.2	0.9	-0.1	0.2	0.1	1.0	0.3
Neuroticism score	0.9	1.9	3.8	-0.3	1.3	-1.9	-0.6	1.9
Weight	0.6	3.2	7.8	1.4	-0.0	-2.4	-2.8	-0.3
Impedance of arm (right)	2.2	10.1	27.3	-0.9	-3.0	5.2	3.7	-0.6
Arm fat percentage (right)	0.9	3.4	8.5	2.9	-0.7	-0.0	-2.5	-1.4
Trunk fat-free mass	0.9	5.2	17.5	-0.3	1.3	-4.2	-2.4	1.1
Hip circumference	0.8	3.3	9.3	1.5	-0.1	-2.1	-3.0	-0.6
Time employed in main current job	1.7	2.0	3.8	-0.2	2.0	-1.8	-1.6	0.5
Alcohol intake versus 10 years previously	0.5	0.8	1.9	0.7	-1.4	0.4	0.7	1.0
Father’s age at death	2.0	2.7	4.6	1.0	-1.2	2.1	1.8	-1.8
Worrier / anxious feelings	0.6	1.1	2.9	-0.7	-0.5	0.2	1.3	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.2	0.0	0.6	-1.2	-0.3	1.5
Falls in the last year	5.0	6.8	13.2	-0.8	2.2	-3.6	-3.0	2.5
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-0.1	0.8	-0.9	-0.2	0.8
Number of live births	0.3	0.4	1.2	0.4	1.1	-0.9	-0.1	0.2
Forced expiratory volume in 1-second (FEV1)	2.5	8.3	15.5	-3.9	-3.4	0.5	3.3	1.6
Pulse rate	0.1	0.2	0.5	-0.5	0.1	-0.1	0.7	0.7
Happiness	0.6	0.7	1.9	-0.1	0.8	-0.7	-0.5	-1.4
Noisy workplace	0.3	0.4	1.1	0.6	0.1	-1.0	-0.5	-0.5
Qualifications: A levels/AS levels or equivalent	2.5	5.5	8.6	-2.6	-2.9	2.5	2.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.9	0.9	-0.1	-0.8	-0.6	0.5
Mouth/teeth dental problems: Dentures	2.4	4.0	6.8	1.7	2.4	-2.6	-2.1	0.7
Asthma	0.3	0.7	2.4	0.4	0.7	0.5	-1.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.4	-0.8	-0.0	-1.1	-1.2	0.5
Medication: Cholesterol lowering	0.7	1.1	2.8	-0.7	0.1	-1.4	-0.4	1.7
Depression (self-reported)	1.8	2.2	7.0	2.7	1.2	-0.4	-1.5	-0.2
Medication: Lansoprazole	1.3	1.5	4.7	-1.1	0.6	-1.0	0.0	2.2
Prospective memory result	1.7	2.1	4.6	0.0	2.1	-1.7	-1.4	1.1
Lung cancer (father)	0.7	0.9	2.7	0.8	-0.2	0.5	-0.9	-1.6
Illnesses of mother	0.9	1.1	3.3	-0.5	-1.8	0.7	0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.6	13.5	-3.7	-3.3	0.6	3.5	0.8
Pulse wave Arterial Stiffness index	1.1	1.3	3.1	-1.8	0.4	0.3	0.8	1.6
Impedance of arm (left)	2.5	11.5	25.8	-1.2	-3.6	5.1	4.2	0.2
Arm fat mass (right)	0.7	3.1	7.7	2.3	-0.5	-1.2	-2.8	-0.8
Trunk predicted mass	0.9	5.4	18.2	-0.3	1.3	-4.3	-2.4	1.2
Standing height	0.3	3.3	6.2	-2.5	-2.3	0.2	2.0	1.0
Length of working week for main job	1.1	1.2	3.7	1.0	-0.6	1.0	0.3	-1.9
Exposure to tobacco smoke at home	0.9	1.0	2.8	0.3	-0.9	0.9	0.8	-1.7
Breastfed as a baby	0.3	0.4	1.3	-1.1	0.5	-0.4	-0.4	0.4
Tense / ‘highly strung’	2.8	4.7	14.0	1.5	3.7	-2.1	-1.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.1	-1.8	0.5	-0.7	0.4	1.6
Hair/balding pattern: Pattern 4	1.0	2.5	5.0	-2.2	-1.1	1.5	1.9	0.7
Birth weight of first child	0.7	1.2	3.9	-0.2	0.4	-2.0	-1.0	0.9
Peak expiratory flow (PEF)	2.1	4.9	10.6	-3.3	-2.4	0.6	2.2	1.7
Pulse wave reflection index	0.8	1.0	1.8	-1.3	0.2	0.7	1.1	1.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.6	-1.6	1.3	-0.8	0.3	-0.1
Loud music exposure frequency	0.7	0.7	1.8	-0.8	-1.1	0.4	1.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.6	-1.0	-1.2	1.0	0.5	0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	-0.5	-1.3	-0.7	0.2	1.3
Blood clot in the leg (DVT)	1.1	1.4	3.2	-0.7	-0.3	1.4	1.8	-1.1
Medication: Paracetamol	0.4	0.7	2.1	1.5	-0.7	-0.4	-0.7	0.0
Headache pain in last month	0.8	1.5	3.5	-0.1	0.4	-1.9	-1.5	1.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	5.6	0.3	-0.2	1.4	1.3	-2.4
Glaucoma (self-reported)	0.2	0.2	0.7	-0.1	-0.2	-0.3	-0.6	0.8
Gout (self-reported)	0.5	0.7	1.3	-0.8	-0.3	1.1	0.6	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	0.2	-1.3	0.5	-0.9	-0.6
Medication: Amlodipine	1.7	2.4	5.2	2.3	-0.5	1.6	0.2	-1.9
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.3	-1.4	0.2	1.5	0.5	-1.5
Birth weight	0.1	0.2	0.8	-0.3	0.2	0.2	0.9	0.4
Chronic bronchitis/emphysema (mother)	3.3	3.9	13.2	-0.5	3.6	-2.1	-1.2	0.0
High blood pressure (siblings)	0.2	0.3	0.7	-0.6	-0.4	0.4	-0.8	-0.3
Forced vital capacity (FVC), Best measure	1.7	6.4	15.2	-2.8	-2.6	1.5	3.9	-0.3
Body fat percentage	0.7	2.8	4.8	2.2	-2.0	1.0	-1.6	-1.3
Leg fat percentage (right)	0.8	2.7	7.5	2.3	-0.5	-0.0	-2.7	-0.9
Arm fat-free mass (right)	0.8	4.0	14.1	-0.0	0.2	-3.8	-2.2	1.0
Exposure to tobacco smoke outside home	0.9	1.3	3.2	1.3	0.3	-1.8	-0.7	0.9
Comparative body size at age 10	1.0	2.7	10.4	1.1	0.8	0.2	-1.1	-3.2
Number of full brothers	0.3	0.4	1.0	0.8	-0.3	-0.5	-0.2	1.0
Worry too long after embarrassment	0.3	0.5	1.8	-0.4	0.0	-0.6	0.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	5.1	-2.3	-1.2	1.4	2.1	1.1
Wheeze or whistling in the chest in last year	1.4	2.5	5.8	0.2	1.8	-1.7	-2.4	0.9
Number of children fathered	1.7	1.9	4.8	-1.5	0.9	-2.2	-0.7	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	-0.6	0.9	0.5	0.3	0.0
Age at first live birth	1.4	2.4	4.1	-1.8	-1.2	1.7	2.0	-0.7
Pulse wave peak to peak time	1.0	1.1	2.5	1.6	-0.7	-0.2	-0.5	-1.6
Health satisfaction	0.8	1.0	2.0	-0.3	1.3	-1.2	-1.4	-0.2
Shortness of breath walking on level ground	1.8	2.2	5.4	0.2	1.5	-1.6	-2.3	-0.6
Qualifications: College or University degree	1.4	4.3	11.2	-1.6	-1.6	3.3	2.2	-0.4
Eye problems/disorders: None of the above	1.8	2.1	5.1	-1.0	-1.7	-1.3	-0.3	2.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	-0.1	-1.4	0.2	0.9	-0.3
Emphysema/chronic bronchitis	1.0	1.1	2.7	0.2	1.4	1.0	0.1	-1.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.8	-0.6	0.1	1.0	1.4	-0.9
Neck or shoulder pain in last month	0.9	1.2	3.2	0.4	0.7	-1.8	-1.4	-0.5
Medication: Blood pressure	0.6	1.0	2.7	0.4	-0.0	-0.9	-1.6	1.1
Angina (self-reported)	0.3	0.4	1.2	0.6	0.5	-0.4	-0.2	1.1
Migraine (self-reported)	0.1	0.1	0.4	0.2	0.5	-0.0	0.0	0.6
Medication: Ibuprofen	0.8	1.0	2.6	-0.8	0.3	-1.6	-0.8	0.9
Medication: Allopurinol	0.2	0.2	0.9	-0.9	-0.2	0.1	0.0	-0.2
Medication: Omeprazole	1.4	1.7	3.3	-1.7	0.9	-1.1	0.1	1.8
Medication: Seretide 50 evohaler	0.3	0.4	1.1	0.8	1.0	0.1	-0.3	-0.2
Mean time to correctly identify matches	2.0	3.8	9.3	2.7	1.1	1.2	0.3	-3.0
Heart disease (mother)	0.3	0.4	1.3	0.7	1.1	0.3	-0.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.1	-0.8	-0.4	-1.4	-0.5	1.1
Whole body fat mass	0.5	2.2	4.8	1.8	-1.4	-0.5	-2.2	-0.9
Leg fat mass (right)	0.8	3.2	9.8	1.9	-0.3	-1.5	-3.1	-0.4
Arm predicted mass (right)	0.9	4.4	14.7	0.3	0.6	-3.8	-2.5	0.7
Pulse rate, automated reading	0.6	2.0	4.6	1.7	2.1	-1.0	-1.2	-0.1
Alcohol intake frequency.	0.2	0.5	1.1	0.4	-0.8	-0.4	-1.0	0.4
Comparative height size at age 10	0.7	3.9	11.8	-0.4	-3.4	1.9	2.0	-0.2
Number of full sisters	1.3	1.6	5.4	-0.8	-1.1	-0.8	0.1	2.3
Suffer from ‘nerves’	0.1	0.2	0.5	-0.6	0.1	0.1	0.7	-0.2
Overall health rating	1.1	2.4	6.7	-0.0	1.6	-2.6	-1.6	0.6
Chest pain or discomfort	2.6	3.7	9.7	-1.1	0.6	-2.5	-0.9	3.1
Had major operations	2.3	2.7	10.5	-3.2	-1.1	-0.5	0.7	1.1
Age at last live birth	2.0	3.0	6.5	-1.8	-1.2	1.6	2.6	-1.0
Family relationship satisfaction	0.8	1.0	1.5	-1.2	1.1	-0.7	-0.6	-1.1
Leg pain on walking	1.9	2.4	6.5	0.8	1.5	-2.5	-1.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	4.5	5.5	14.7	1.2	1.1	-3.8	-2.3	2.2
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.3	-0.4	0.4	-1.2	-1.8	-1.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	5.2	1.1	-0.1	2.3	1.5	-0.5
Medication: Aspirin	1.2	1.6	3.4	1.8	-1.0	1.3	1.0	-0.9
Supplements: Vitamin C	0.1	0.2	0.7	0.3	0.2	0.8	0.3	0.1
Knee pain experienced in last month	3.9	6.1	18.1	-0.0	2.0	-4.3	-2.8	0.6
Hypertension (Self-reported)	0.4	1.1	3.5	0.2	0.8	-0.1	-1.9	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	9.7	-2.5	0.1	-1.1	-0.4	3.1
Illnesses of father: Heart disease	0.4	0.6	2.6	0.4	-0.2	-0.4	0.3	1.6
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.6	-0.2	0.1	-0.3	-0.4
Smoking status: Previous	0.7	1.1	2.0	1.4	1.3	0.7	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	0.7	0.9	-1.1	-0.8	0.9
Whole body fat-free mass	0.9	5.0	17.0	0.2	1.1	-4.1	-2.6	0.7
Leg fat-free mass (right)	0.8	4.2	14.6	0.4	0.8	-3.8	-2.4	0.1
Arm fat percentage (left)	0.7	2.8	6.9	2.6	-1.0	-0.1	-2.3	-1.0
Average weekly red wine intake	2.6	3.9	5.8	0.9	-2.0	2.4	2.4	-1.9
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.2	1.5	-0.1	-0.6	-1.2	-0.9
Mood swings	0.2	0.4	0.7	-0.5	0.5	-0.8	-0.6	0.8
Loneliness, isolation	2.4	3.3	7.2	1.4	2.0	-2.7	-1.7	0.7
Long-standing illness, disability or infirmity	1.1	1.7	4.2	1.0	1.1	-1.4	-2.0	-0.0
Ever had bowel cancer screening	0.8	0.9	2.2	0.5	0.5	-1.2	-1.5	-0.7
Diabetes diagnosed by doctor	0.4	0.6	1.9	0.2	-0.5	0.7	0.5	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.4	-0.4	0.4	0.3	-0.7
Friendships satisfaction	0.4	0.5	1.4	0.5	0.9	-0.2	-0.0	-1.2
Qualifications: nursing, teaching	1.6	2.5	5.2	-0.0	-2.3	2.2	1.6	-0.1
Commuting to job workplace: Walk	1.5	1.6	5.2	0.5	-0.7	2.3	1.0	-1.0
Eye problems/disorders: Cataract	1.4	1.6	3.1	0.3	0.9	1.4	1.5	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.3	-0.9	0.3	-1.5	-0.8	0.9
Medication for cholesterol	1.0	1.5	3.1	-0.4	-1.8	1.1	1.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.7	0.6	-0.9	-0.4	-0.2
Back pain experienced in last month	6.1	8.9	19.8	-0.6	2.7	-4.4	-2.9	2.9
Mineral and other dietary supplements	0.6	0.8	1.5	1.0	0.2	0.5	1.2	-1.0
Breast cancer (self-reported)	0.1	0.1	0.4	-0.0	-0.0	0.1	0.6	0.3
Asthma (self-reported)	0.4	0.8	2.6	0.3	0.9	0.6	-1.6	-0.3
Osteoporosis (self-reported)	1.0	1.2	2.4	-0.5	1.5	0.9	-0.5	-1.6
Osteoarthritis (self-reported)	2.7	3.4	5.1	1.5	1.8	-2.1	-2.3	-1.6
Medication: Aspirin	0.7	1.0	2.6	1.6	-0.8	0.9	0.6	-0.7
Medication: Gliclazide	1.4	1.6	3.4	1.5	1.2	-1.0	-1.8	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.4	1.2	-0.9	-0.3	0.2
Smoking status: Current	1.5	2.4	4.1	-1.3	1.5	-1.9	-0.5	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	11.2	-2.3	-3.4	0.9	2.6	0.0
Whole body water mass	0.9	5.2	17.6	0.2	1.1	-4.2	-2.6	0.6
Leg predicted mass (right)	0.7	4.0	14.0	0.3	0.7	-3.7	-2.3	0.2
Arm fat mass (left)	0.8	3.2	7.7	2.4	-0.5	-1.3	-2.8	-0.6
Number of self-reported non-cancer illnesses	1.4	2.4	7.7	0.7	1.6	-1.1	-2.8	0.5
Average weekly champagne plus white wine intake	0.6	0.8	1.3	-0.1	1.1	-1.1	-0.9	-0.7
Miserableness	1.1	1.8	4.3	-1.5	0.8	-2.1	-1.2	0.7
Guilty feelings	1.5	2.3	4.4	-1.0	0.5	-2.1	-1.3	2.0
Wears glasses or contact lenses	0.2	0.3	1.0	-1.0	0.0	0.1	-0.3	0.4
Ever taken oral contraceptive pill	0.5	0.6	1.4	-0.5	-0.8	0.2	1.2	0.7
Hearing aid user	0.5	0.6	1.9	1.4	0.5	-0.5	-0.6	0.1
Mother’s age at death	5.6	7.0	10.2	-2.8	-1.9	3.0	3.2	-2.1
Financial situation satisfaction	1.0	1.2	4.2	-0.1	0.6	-1.2	-2.0	-0.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	4.0	0.5	0.7	0.2	-0.7	-2.0
Commuting to job workplace: Public transport	0.2	0.2	0.7	0.0	0.3	0.8	0.0	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	1.0	0.2	0.1	0.1	-0.5	1.0
Medication: Blood pressure	0.3	0.5	1.6	0.7	0.5	0.4	-1.3	-0.2
Pain type(s) experienced in last month: Hip pain	2.7	3.4	6.7	2.1	1.1	-2.6	-2.1	-0.2
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.6	-0.8	0.8	-1.2	-1.6	2.2
High cholesterol (Self-reported)	1.1	1.9	6.5	1.2	2.5	-0.8	-1.1	0.4
Medication: Bendroflumethiazide	0.5	0.8	1.7	0.2	-1.0	-1.3	-1.0	0.3
Medication: Paracetamol	0.3	0.4	1.4	0.6	-1.2	0.4	0.5	-0.2
Medication: Lisinopril	0.5	0.6	1.2	0.1	0.3	0.7	-1.1	-1.0
Medication: Atorvastatin	0.2	0.3	0.7	0.2	0.9	-0.7	-0.2	0.1
Illnesses of father: High blood pressure	1.1	1.4	3.7	1.0	-1.2	1.9	0.9	-0.3
Alcohol drinker status: Never	0.1	0.1	0.5	0.1	-0.2	0.1	0.4	-0.7
Ever smoked	0.3	0.5	1.0	-0.6	0.6	1.0	1.0	-0.3
Basal metabolic rate	0.8	4.6	14.7	0.4	0.7	-3.8	-2.7	0.6
Leg fat percentage (left)	0.8	2.9	6.8	2.4	-0.3	0.0	-2.6	-1.4
Arm fat-free mass (left)	0.8	4.2	13.4	0.6	0.8	-3.7	-2.6	0.3
Number of operations (self-reported)	0.4	0.5	1.5	0.3	-0.1	-1.2	-0.3	-1.0
Average weekly beer plus cider intake	0.8	1.1	2.8	1.3	1.7	-0.7	-0.5	0.6
Irritability	0.4	0.7	1.3	-1.2	0.4	-1.1	0.7	0.6
Risk taking	0.7	1.0	2.8	-1.7	0.3	-1.1	1.0	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.3	-0.0	0.6	0.5	-0.6
Fractured/broken bones in last 5 years	0.5	0.7	2.5	0.3	1.6	0.6	-0.7	0.3
Age started oral contraceptive pill	2.1	2.7	7.8	-1.1	-1.5	2.8	1.3	-0.6
Diastolic blood pressure, automated reading	0.4	1.3	4.6	1.3	0.5	-0.2	-2.1	0.3
Ever depressed for a whole week	1.7	2.1	5.8	-2.4	0.6	-0.1	1.6	1.4
Unable to work because of sickness or disability	2.2	2.8	4.6	1.6	2.0	-1.7	-2.1	0.2
Commuting to job workplace: Cycle	0.6	0.7	2.5	-0.2	-0.2	0.9	1.6	0.5
Myopia	0.8	1.1	4.4	0.6	-0.8	0.2	0.5	2.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.0	-0.3	-1.6	0.7	2.4	-1.4
Cholesterol lowering medication	1.4	2.1	7.4	1.2	2.7	-0.5	-1.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	5.0	-1.0	1.8	-2.2	-1.0	2.2
Pain experienced in last month	5.8	9.7	27.9	0.0	-1.6	5.3	3.9	-1.6
Supplements: Calcium	0.2	0.2	0.4	-0.6	-0.3	-0.4	-0.5	0.4
Basal cell carcinoma (self-reported)	1.1	1.3	3.8	2.0	0.5	-0.9	-1.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	0.2	0.4	-1.1	0.1	0.7
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.7	-1.1	-0.6	1.7	2.2	-1.1
Heart disease (siblings)	0.9	1.0	2.0	1.4	1.0	-1.2	-0.9	0.4
Alcohol drinker status: Previous	1.1	1.3	2.3	1.5	1.5	0.0	-0.8	-1.0
Pack years of smoking	0.3	0.5	1.3	1.2	0.5	0.1	0.8	0.4
Impedance of whole body	2.9	15.0	34.5	-1.7	-4.1	5.9	4.5	0.4
Leg fat mass (left)	0.8	3.2	8.8	2.1	-0.2	-1.4	-3.0	-0.9
Arm predicted mass (left)	1.0	4.9	14.6	0.4	1.1	-3.8	-2.9	0.4