Hub : Genes

SWAP70

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1900 0.0440 4.5e-13 0.069 0.139 0.127 0.129 0.130 8.4e-09 1.5e-16 3.1e-15 1.8e-15 1.6e-15
2 GTEx Artery Aorta 0.1420 0.0600 1.6e-03 0.013 NA 0.079 NA 0.060 5.7e-02 NA 3.7e-05 NA 3.2e-04
3 GTEx Cells EBV-transformed lymphocytes 0.3690 0.0780 3.6e-07 0.308 NA 0.265 NA 0.299 1.0e-10 NA 3.3e-09 NA 2.3e-10
4 GTEx Lung 0.0771 0.0318 1.2e-03 0.059 NA 0.023 NA 0.042 2.8e-05 NA 6.3e-03 NA 3.8e-04
5 GTEx Nerve Tibial 0.1799 0.0611 2.1e-03 0.036 NA 0.123 NA 0.111 1.4e-03 NA 5.0e-09 NA 3.1e-08
6 GTEx Skin Not Sun Exposed Suprapubic 0.3790 0.0870 2.9e-05 0.034 NA 0.062 NA 0.057 5.5e-03 NA 2.5e-04 NA 4.4e-04
7 GTEx Skin Sun Exposed Lower leg 0.1670 0.0450 4.7e-07 0.049 NA 0.097 NA 0.100 6.7e-05 NA 2.0e-08 NA 1.3e-08
8 ROSMAP Brain Pre-frontal Cortex 0.0519 0.0232 6.0e-04 0.034 0.021 0.032 0.025 0.038 2.7e-05 9.7e-04 4.7e-05 3.1e-04 1.1e-05
9 YFS Blood 0.0853 0.0211 1.1e-16 0.072 0.066 0.077 0.079 0.079 1.7e-22 9.5e-21 4.7e-24 1.5e-24 1.9e-24
10 TCGA Pancreatic Adenocarcinoma 0.1670 0.0900 3.1e-03 0.023 0.058 0.055 NA 0.020 3.7e-02 1.9e-03 2.5e-03 NA 4.9e-02
11 TCGA Prostate Adenocarcinoma 0.0399 0.0261 6.7e-03 0.007 0.014 0.005 NA 0.009 5.3e-02 1.2e-02 9.0e-02 NA 3.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.8 1.3 3.2 -1.8 -1.3 0.8 0.3 -0.4 -1.1 -1.0 -0.9 -1.7 -1.4 -0.7
Bipolar Disorder or Schizophrenia 0.2 0.5 2.1 -0.3 -0.2 0.4 0.6 0.3 -1.0 -0.7 0.2 -1.4 -1.1 0.4
Depressed Affect (Nagel 2018) 0.7 1.5 4.6 2.1 1.1 -1.6 -2.0 -1.5 0.4 0.0 -0.7 0.3 0.0 -1.3
Depression (Nagel 2018) 0.4 0.6 2.2 1.1 0.2 -1.2 -0.9 -1.5 -0.0 -0.2 -0.7 0.6 -0.4 -0.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 1.2 0.9 -0.1 -0.2 0.5 -1.1 -0.2 -0.6 0.5 0.5 0.3 0.6
Neuroticism (Nagel 2018) 1.3 3.0 7.1 2.3 1.5 -2.7 -1.7 -1.1 2.2 1.2 -0.0 2.3 1.5 -0.4
Schizophrenia (2018) 0.2 0.5 1.1 1.0 0.7 -0.2 0.5 0.7 -0.4 -0.0 1.0 -0.5 -0.4 1.0
Schizophrenia vs Biploar Disorder 0.7 0.9 4.0 -0.6 1.1 2.0 -0.9 0.8 1.2 0.7 -0.8 0.4 0.7 -0.2
Worry (Nagel 2018) 1.0 2.0 5.4 1.2 1.3 -1.9 -1.1 -1.2 2.3 1.0 0.1 2.2 1.4 0.2
Alzheimer’s Disease (in mother) 1.6 1.8 4.4 0.4 0.1 -1.4 -1.1 1.1 1.8 1.7 0.1 1.8 2.1 -1.4
Alzheimer’s Disease (in father) 0.7 0.8 2.5 0.7 -1.3 -0.9 -0.2 -0.8 -0.1 0.2 0.3 1.6 1.6 -0.3
Alzheimer’s Disease (including proxy) 2.3 3.3 8.2 0.8 -0.7 -2.5 -1.1 0.8 2.3 2.0 0.1 2.9 2.6 -1.5
Crohns Disease (2017) 0.9 1.9 8.7 -0.6 0.5 -0.2 -1.3 0.7 3.0 1.9 0.3 1.0 2.1 -0.1
Irritable Bowel Disease (IBD) 0.7 1.6 4.1 1.1 2.0 -0.5 0.1 1.7 1.7 0.8 1.5 0.3 1.5 0.9
Ulcerative Colitis (UC) 1.1 2.1 5.7 2.3 2.4 -0.6 1.3 1.6 -0.5 -0.8 2.1 -0.6 0.5 1.6
Major Depression (MDD) 0.1 0.2 0.6 -0.8 0.8 -0.2 -0.2 -0.2 0.2 0.0 0.2 -0.1 0.0 0.6
Reaction Time 0.1 0.3 0.9 0.7 0.2 0.3 0.1 -0.8 -0.9 -0.9 -0.3 0.0 0.3 0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.8 0.7 1.2 -0.4 1.2 -0.7 -0.3 -0.5 0.7 0.2 -1.1 1.4
Breast Cancer 2.0 4.8 11.2 2.8 3.4 0.0 2.2 -1.0 -1.1 -2.1 1.1 -2.3 -3.0 2.4
Ovarian Cancer 1.2 1.6 9.5 0.8 -1.4 -0.9 -0.6 -3.1 -0.1 -1.6 -0.6 -0.7 -0.9 -0.3
Prostate Cancer 3.1 4.3 11.7 0.6 1.6 -1.7 -1.0 1.9 2.8 3.4 1.4 2.7 2.9 -0.3
Age at First Birth 1.3 1.9 4.4 1.2 -0.5 1.1 -1.6 -1.3 -1.4 -1.2 -2.1 -1.1 -1.7 -1.5
Bipolar Disorder (2011) 0.9 0.8 2.8 -0.0 -0.7 0.8 0.3 -1.4 -1.7 -1.3 -0.7 -0.8 -0.5 -0.6
Body Mass Index (BMI) (2010) 1.6 2.2 6.4 -1.2 -1.1 1.1 -2.2 1.4 1.4 1.0 -1.7 -0.9 0.6 -2.5
Coronary Artery Disease (CAD) 2.7 3.2 7.7 0.1 -1.6 0.6 -1.0 -2.8 -2.4 -2.8 -1.2 -2.5 -1.5 -0.2
Crohns Disease (2012) 0.4 0.6 2.9 0.0 -0.5 0.5 -0.7 -1.7 1.1 -0.5 -0.4 -0.9 -0.6 0.2
Mean Putamen Volume 2.6 3.0 6.1 -1.0 -0.8 2.1 -0.7 -1.7 -2.4 -2.2 -1.6 -2.5 -1.9 -0.5
Fasting Glucose 0.4 0.4 1.6 0.7 1.2 0.8 0.3 -0.4 0.8 -0.4 0.2 -0.3 -0.8 0.4
HbA1C 3.6 3.9 14.5 0.3 -1.1 -2.2 0.0 1.9 2.1 2.8 1.8 2.0 3.8 -0.1
HDL Cholesterol 0.6 1.0 3.9 0.6 -0.9 -1.7 0.6 -1.5 -0.3 -0.0 0.4 2.0 0.4 0.6
LDL Cholesterol 1.3 2.1 8.0 -0.6 -1.5 1.9 -0.4 1.2 -1.4 1.0 0.0 1.9 2.8 0.2
Lupus 0.4 0.6 2.5 -0.2 -0.8 -0.8 0.1 1.6 0.0 0.3 -0.0 0.8 1.5 0.2
Neuroticism (2016) 1.7 2.5 8.5 0.7 0.3 -2.3 -0.1 0.7 2.9 2.9 1.0 1.5 1.0 -0.0
Primary Biliary Cirrhosis 0.7 1.0 4.1 0.4 0.1 -0.5 0.8 2.0 0.0 1.3 1.5 1.1 0.9 0.6
Rheumatoid Arthritis 3.6 4.9 12.4 0.2 1.1 2.2 1.4 -1.8 -2.5 -3.3 -0.3 -3.4 -3.5 1.6
Schizophrenia (2014) 0.1 0.3 1.2 1.1 0.7 -0.4 0.5 0.4 -0.1 0.0 0.5 0.1 -0.2 0.7
Triglycerides 0.5 0.8 2.9 -0.2 -0.1 1.7 -1.0 1.5 0.2 -0.0 -1.3 -0.5 0.4 -0.6
Type 2 Diabetes (T2D) (2012) 1.3 1.5 5.4 1.0 1.7 -0.0 2.3 1.3 0.6 0.7 1.5 -0.5 -0.8 1.4
Ulcerative Colitis 1.0 1.5 2.9 1.6 1.5 -0.4 1.0 1.5 -1.6 -0.7 1.7 -0.8 0.1 1.3
Blood Eosinophil Count 0.2 1.9 11.4 -0.3 0.0 1.8 0.6 3.4 1.4 0.1 0.2 0.7 1.8 0.5
Blood Platelet Count 1.0 12.1 36.8 -1.4 0.1 -1.8 -0.7 6.1 4.5 5.6 2.0 4.1 4.1 -0.8
Blood Red Count 0.8 7.8 31.4 -2.8 -3.8 0.2 -4.7 -0.5 -5.6 -1.5 -1.8 -1.0 0.4 -1.9
Blood White Count 1.1 8.3 25.4 2.9 3.5 -0.5 4.1 0.6 -0.6 -2.0 3.4 -1.2 -3.3 5.0
Heel T-Score 0.6 5.1 12.8 0.5 -2.2 -3.4 0.3 2.4 0.5 2.9 2.2 3.6 2.7 0.5
BMI 0.1 0.5 1.5 1.0 -0.7 0.4 0.0 -0.5 0.2 -1.2 -0.0 -1.1 -0.7 -0.0
Height 0.1 1.5 7.0 1.7 -0.0 -0.9 0.2 1.5 -1.2 -0.9 1.0 0.7 2.6 0.2
Waist Hip Ratio (WHR) 2.0 8.8 24.7 2.0 0.6 -3.3 1.3 1.6 1.8 4.1 3.8 5.0 3.7 2.0
Systolic Blood Pressure 7.3 36.5 153.8 -2.7 -0.4 5.6 0.0 -4.8 -3.5 -7.4 -4.8 -12.4 -9.8 -0.1
Smoking Status 0.6 1.5 6.1 1.5 1.2 0.1 -0.2 -0.4 0.6 0.6 0.9 2.5 2.0 1.1
Allergy or Eczema 0.5 1.4 4.6 0.9 0.6 -0.1 1.3 0.1 -0.6 0.6 1.6 2.2 1.1 1.8
Cardiovascular Disease 6.0 19.8 67.1 2.5 2.7 1.2 1.8 -5.3 -1.3 -6.9 -0.8 -8.2 -7.2 1.5
Hypothyroidism (self reported) 2.3 5.2 18.1 1.8 -0.2 0.8 0.0 -2.6 -2.9 -4.2 -0.5 -3.6 -2.7 0.5
Respiratory disease 0.3 0.6 2.9 1.7 0.7 -0.4 0.6 0.1 1.0 -0.5 0.7 -0.8 -0.8 0.5
Type 2 Diabetes (T2D) (2018) 1.1 2.0 5.4 2.3 1.3 -1.7 1.3 0.1 1.8 0.7 1.7 1.5 -0.0 1.3
Lung FEV1/FVC ratio 1.1 5.3 15.4 -2.6 -3.9 0.6 0.3 2.5 0.4 3.0 1.4 2.3 3.6 0.8
Lung FVC 0.2 0.9 3.5 -0.6 0.7 0.3 0.6 -0.9 0.8 -0.4 -1.0 -1.9 -1.4 -0.8
Neuroticism 1.4 3.3 9.9 1.9 1.6 -3.2 -0.6 -1.0 2.0 1.5 1.0 2.7 1.9 0.5
Chronotype (morning person) 0.3 0.6 2.8 -0.2 0.9 1.7 -0.7 1.2 -0.7 -0.1 -0.8 -0.4 0.3 -0.1
Hair Pigment 0.1 2.5 7.8 0.7 1.1 1.4 1.0 -0.9 -0.9 -2.8 -0.6 -2.1 -2.8 1.0
Tanning 0.1 1.1 4.0 -2.0 -0.8 0.7 -1.4 0.3 0.9 0.7 -1.1 0.6 0.9 -1.1
Hand grip strength (left) 0.2 0.4 1.0 -0.2 -0.4 -0.4 -1.0 1.0 -0.0 -0.4 -0.4 -0.3 0.9 -1.0
Number of treatments/medications taken 1.0 1.7 4.0 1.9 2.0 0.6 0.8 -1.5 1.1 -1.6 0.0 -1.3 -1.2 1.0
Average weekly spirits intake 0.5 0.6 3.2 -0.6 -0.5 1.8 -0.9 -0.0 -0.3 0.3 -1.1 -0.2 -0.6 -0.9
Sensitivity / hurt feelings 1.5 2.6 6.1 1.9 2.0 -2.5 0.3 0.0 1.2 1.3 1.6 2.1 2.0 1.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 -0.3 0.3 -0.5 -0.2 -1.1 0.6 -0.1 -1.0 0.3 -0.6 -0.4
Hearing difficulty/problems: Yes 0.5 0.8 2.6 -1.1 -1.6 0.7 0.1 -1.1 -0.8 -1.2 -0.3 -0.5 -0.5 0.6
Relative age of first facial hair 0.2 0.4 1.0 -1.0 0.4 -0.1 0.7 0.7 -0.5 -0.7 0.0 -1.0 -0.6 0.6
Other serious medical condition/disability diagnosed by doctor 1.7 2.1 4.9 1.5 1.4 -0.8 2.0 1.2 1.7 1.0 2.0 0.6 -0.0 2.2
Ever used hormone-replacement therapy (HRT) 1.3 1.6 7.4 0.3 -0.7 -0.8 -0.1 -0.5 1.6 1.1 0.4 2.7 2.2 0.5
Ever had hysterectomy (womb removed) 1.0 1.1 2.8 -0.5 -1.6 0.5 -1.4 -0.8 0.3 0.6 -0.8 1.4 1.7 -1.0
Systolic blood pressure, automated reading 4.3 12.4 50.0 -2.5 -1.6 3.7 -1.7 -1.8 -1.3 -2.8 -4.1 -7.1 -5.3 -1.7
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.7 0.2 1.3 -0.4 1.0 0.7 0.9 0.2 0.2 -0.3 -0.9 0.3
Angina 1.6 2.1 6.1 1.5 0.2 -0.0 0.9 -1.9 -1.4 -2.5 0.2 -2.2 -1.8 -0.4
Medication for hormone replacement therapy 0.3 0.3 1.2 -0.7 -0.3 1.1 0.1 -0.0 0.9 -0.0 0.0 0.2 0.3 0.6
Vitamin and mineral supplements 0.3 0.4 1.0 -0.7 -0.5 0.4 0.6 0.4 -0.9 0.4 0.8 -0.4 1.0 -0.0
Supplements: Zinc 0.4 0.4 1.3 1.2 0.4 -0.0 0.9 -0.1 -0.2 -0.9 -0.2 0.1 -1.1 0.7
Medication: Co-codamol 0.3 0.3 0.9 0.2 -0.3 0.9 -0.4 0.4 0.2 1.0 0.2 0.6 0.9 0.4
Medication: Metformin 0.1 0.2 0.6 0.1 0.7 0.2 0.5 0.1 -0.2 -0.3 -0.0 -0.8 -0.8 0.1
Diabetes (father) 2.0 2.5 5.1 1.8 1.6 -2.3 2.0 0.7 1.2 1.4 1.7 1.4 -0.9 1.9
Diabetes (mother) 0.6 0.8 3.5 0.4 0.3 -0.6 1.9 -0.5 -0.5 -0.2 0.8 0.1 -1.4 1.2
Severe depression (siblings) 0.6 0.7 3.0 -0.8 -0.1 0.2 -0.1 -0.5 -0.2 -1.2 -1.2 -0.7 -1.7 0.1
Pack years adult smoking proportion 1.5 2.3 6.1 0.8 2.4 -0.2 2.5 -0.7 -1.5 -0.6 1.9 -0.0 -1.1 2.2
Impedance of leg (right) 2.0 9.9 36.1 0.2 -0.3 -3.9 -1.0 2.7 0.4 4.1 2.4 6.0 4.9 1.4
Leg fat-free mass (left) 0.6 3.2 12.4 1.1 0.1 1.9 1.6 -1.2 -0.9 -2.8 -0.1 -3.5 -2.4 0.0
Trunk fat percentage 0.9 3.5 8.4 2.2 -0.2 -2.0 0.8 1.1 0.8 2.6 2.5 2.9 1.8 1.5
Hand grip strength (right) 0.3 0.7 2.3 -0.3 -0.6 0.2 -1.5 -0.5 0.1 -0.8 -1.3 0.0 0.9 -1.4
Townsend deprivation index at recruitment 0.6 0.9 2.6 0.5 -1.6 -0.6 0.3 -1.5 -1.1 0.0 1.1 0.8 1.0 0.4
Current tobacco smoking 1.9 3.0 7.8 2.4 1.2 -1.7 0.4 -0.3 0.0 1.4 2.6 2.8 2.3 1.2
Average weekly fortified wine intake 1.4 1.7 3.8 0.0 -1.4 -1.6 -1.6 0.2 0.3 1.1 -0.3 1.6 1.9 -2.0
Maternal smoking around birth 1.0 1.4 6.8 -0.1 0.9 1.1 0.0 -2.6 -0.6 -1.8 0.2 -0.5 -1.1 1.1
Fed-up feelings 0.5 0.9 3.0 0.9 1.2 -1.0 -1.7 -1.6 0.1 0.5 -0.4 0.7 0.3 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.8 0.3 -0.5 -0.8 -1.0 -1.3 0.3 0.4 -0.8 1.0 0.3 -0.7
Relative age voice broke 0.6 0.9 3.0 0.6 1.7 -1.4 1.0 0.4 1.0 0.0 1.0 0.3 0.3 1.4
Taking other prescription medications 0.4 0.6 2.7 1.6 0.7 -0.6 -0.4 -1.5 0.2 -0.4 -0.3 0.3 0.1 0.1
Age when periods started (menarche) 0.5 1.2 3.2 -1.5 -1.2 1.8 -1.0 -1.1 -0.3 -1.1 -1.6 0.3 -0.3 -0.4
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 5.5 2.3 -0.5 -2.3 0.5 0.3 0.4 1.3 2.0 2.3 1.4 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 10.8 -0.7 -1.5 -0.7 0.3 3.3 0.0 2.5 1.0 0.0 0.2 0.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 3.5 -0.7 -0.1 0.9 -0.2 0.2 -1.0 -1.4 -0.9 -1.9 -0.8 -0.3
Qualifications: CSEs or equivalent 0.9 1.2 3.3 0.1 1.0 -1.1 1.7 0.3 -0.2 0.9 1.8 -0.4 -1.0 1.4
Serious illness, injury or assault to yourself 0.4 0.5 2.5 0.4 0.0 -1.1 -0.8 -0.3 0.1 0.2 -0.6 -0.5 -0.6 -1.6
High blood pressure 3.2 9.0 32.8 1.9 0.6 1.4 0.7 -3.7 -0.9 -4.6 -1.3 -5.7 -4.7 0.7
Hayfever, allergic rhinitis or eczema 0.9 1.9 5.9 1.2 0.8 -0.2 1.3 0.1 -1.1 0.7 2.0 2.4 1.5 1.8
Multivitamins +/- minerals 0.3 0.4 2.0 -0.1 0.2 0.1 -0.1 -0.1 1.4 0.0 -0.7 -0.1 -1.3 0.2
Stomach or abdominal pain in last month 0.4 0.4 2.3 0.8 1.5 -0.5 0.7 -0.2 -0.4 -0.3 0.4 -0.7 -0.4 0.3
Supplements: Glucosamine 1.1 1.4 4.2 -0.5 -0.3 -0.3 -1.2 0.8 1.0 1.9 -0.3 1.9 2.0 -0.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 6.8 1.1 0.6 -2.6 -0.1 -0.1 0.2 0.3 0.5 0.6 -0.1 -0.1
Medication: Atenolol 1.7 2.1 6.1 0.9 1.2 1.2 1.4 -1.3 -1.1 -1.8 0.1 -2.2 -2.5 1.1
Medication: Levothyroxine sodium 1.9 3.1 7.1 2.1 0.7 -0.3 1.2 -1.9 -1.7 -2.5 0.7 -2.7 -2.3 1.5
Sitting height 0.6 4.3 13.0 3.6 -1.6 -3.4 -1.4 -1.9 -2.4 -2.5 -0.5 -0.3 0.4 -1.5
Chronic bronchitis/emphysema (father) 3.4 4.0 8.8 1.5 1.4 -2.2 1.4 1.4 3.0 2.1 2.8 2.4 0.7 1.8
High blood pressure (mother) 2.3 3.3 11.7 -0.2 0.9 1.0 2.0 -1.1 -1.1 -1.5 0.7 -2.7 -3.4 2.5
Body mass index (BMI) 0.2 0.8 2.2 1.5 -0.4 0.4 1.1 -1.0 -0.7 -0.7 0.7 -1.0 -1.2 0.4
Impedance of leg (left) 1.8 8.9 37.0 -0.6 -0.7 -3.5 -1.6 2.0 0.5 4.0 1.4 6.1 4.8 0.8
Leg predicted mass (left) 0.6 3.2 12.2 1.0 -0.0 2.0 1.5 -1.2 -0.9 -2.8 -0.2 -3.5 -2.3 -0.0
Trunk fat mass 0.4 1.7 4.5 2.1 -0.3 -1.3 1.0 0.6 0.2 1.3 2.1 1.6 1.0 1.3
Waist circumference 0.2 0.8 3.7 1.9 -0.1 -0.3 1.1 -0.1 0.2 0.1 1.4 0.7 0.1 1.3
Number of incorrect matches in round 1.0 1.7 5.2 0.9 -1.8 -0.7 -1.7 -0.2 -0.1 -0.5 -2.2 0.7 0.2 -2.3
Past tobacco smoking 0.4 0.7 3.4 -1.0 -0.7 0.3 0.7 -0.0 -0.9 -0.4 0.0 -1.9 -1.3 -0.3
Alcohol usually taken with meals 0.2 0.4 1.4 0.6 0.2 -0.8 -1.2 0.6 0.6 -0.4 -0.6 -0.4 -0.2 -0.6
Nervous feelings 1.2 2.2 7.0 2.0 -0.2 -2.7 -0.8 -1.5 1.3 0.7 0.2 2.2 1.8 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.4 1.1 0.9 -1.5 1.1 -1.5 0.1 0.0 0.7 0.4 -0.3 0.6
Hearing difficulty/problems with background noise 0.4 0.7 3.9 -0.3 -2.0 -0.4 -0.4 -1.3 -1.0 -0.8 -0.2 -0.1 0.5 0.0
Hair/balding pattern: Pattern 2 1.7 2.2 5.0 2.1 -0.2 -1.9 -0.5 -2.2 -0.9 -1.9 -0.1 -1.6 -1.8 -0.2
Had menopause 0.4 0.5 2.0 0.2 -0.8 -0.9 0.2 -0.8 0.9 -0.2 -0.2 1.4 0.5 0.1
Had other major operations 0.6 0.7 3.5 0.4 -0.0 -1.9 0.8 0.5 0.7 1.2 0.5 0.9 0.6 -0.2
Forced vital capacity (FVC) 0.1 0.3 1.4 -0.1 -0.5 0.7 0.7 -0.5 -0.3 -0.8 0.0 -1.2 -0.1 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 8.4 -0.6 -1.1 0.1 0.5 2.9 0.7 2.3 1.0 0.3 0.4 0.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.6 -0.8 -0.7 -1.3 -1.0 -0.7 0.8 -0.3 -0.5 0.7 1.1 -1.1
Qualifications: None of the above 0.7 1.6 3.3 1.5 -0.9 -0.9 -1.8 -1.8 -0.9 -1.1 -1.1 0.7 1.4 -1.2
Financial difficulties in last 2 years 0.7 0.9 3.6 1.2 -0.2 -1.4 0.2 -1.9 0.9 -1.0 -0.3 1.1 -0.3 0.4
Mouth/teeth dental problems 1.1 1.8 5.2 -2.3 -0.4 1.7 -1.5 1.7 -0.5 0.5 -1.9 -0.8 -0.9 -0.8
Heart attack 2.2 2.8 5.4 0.1 -0.5 1.3 -1.5 -2.3 -2.0 -2.0 -1.9 -1.9 -1.4 -2.0
Allergy 0.5 1.2 3.0 -1.7 -0.6 1.5 -0.6 -0.2 1.2 -0.5 -1.6 -1.2 -0.8 -0.7
Pain all over the body in last month 0.9 0.9 2.6 0.1 -0.5 0.6 -0.1 -0.0 -1.5 -0.9 -0.9 -1.6 -1.6 -0.6
Diabetes (self-reported) 0.4 0.6 1.4 1.1 0.7 -1.1 0.7 -0.2 1.2 0.4 0.7 0.6 -0.8 0.5
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.2 -0.7 -0.2 0.6 -1.1 0.4 -0.5 0.6 -0.9 0.8 -0.0 -0.1
Medication: Ramipril 1.3 1.7 5.0 1.2 2.2 1.2 1.1 -0.5 0.8 -1.2 0.2 -1.5 -1.5 1.6
Medication: Simvastatin 2.2 3.3 12.2 3.5 2.2 -1.7 1.5 -0.6 -0.4 -1.6 1.7 -1.8 -1.8 1.3
Fluid intelligence score 0.4 0.8 2.3 0.2 1.1 -0.1 1.4 0.3 -0.3 -0.8 1.4 -0.4 -0.1 1.5
Illnesses of siblings 1.0 1.4 5.3 -0.8 0.3 1.1 -0.3 2.3 1.1 1.5 0.7 1.2 1.6 0.2
Neuroticism score 1.3 2.7 9.2 1.8 1.5 -3.0 -0.7 -1.2 1.5 1.2 0.6 2.4 1.7 0.3
Weight 0.2 0.8 2.7 1.6 -0.5 0.4 1.0 -0.6 -0.8 -1.1 0.7 -1.0 -0.5 0.5
Impedance of arm (right) 1.1 5.3 16.7 0.4 0.7 -2.2 -0.2 2.8 1.2 3.8 1.7 4.1 2.5 1.8
Arm fat percentage (right) 0.4 1.4 4.5 1.8 -0.3 -0.8 1.3 0.5 -0.1 1.3 2.1 0.8 0.3 1.5
Trunk fat-free mass 0.7 4.1 14.7 0.4 -0.7 2.2 0.8 -1.7 -2.1 -3.8 -0.9 -3.5 -2.0 -0.4
Hip circumference 0.3 1.5 3.4 1.0 -0.0 1.4 0.9 -0.5 -1.3 -1.8 0.0 -1.8 -1.8 0.9
Time employed in main current job 1.5 1.7 4.6 2.2 1.2 -1.4 -1.0 0.3 1.9 1.0 0.4 1.4 1.8 -0.1
Alcohol intake versus 10 years previously 2.1 3.1 8.4 -1.1 -0.4 1.9 1.1 -1.1 -1.8 -2.6 -0.7 -2.9 -2.8 0.7
Father’s age at death 0.5 0.7 1.8 1.3 -0.3 -0.1 0.1 0.6 0.6 1.2 1.2 1.4 0.8 0.1
Worrier / anxious feelings 0.7 1.3 3.9 0.5 1.1 -1.5 -1.1 -1.4 2.0 0.6 -0.3 1.6 0.9 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 7.5 2.7 1.7 -1.2 1.2 -2.3 0.9 -0.7 1.3 0.1 -0.5 1.1
Falls in the last year 1.9 2.6 6.1 2.5 2.0 -1.7 2.1 1.2 0.8 1.0 1.9 1.1 0.3 1.9
Hair/balding pattern: Pattern 3 0.8 1.2 4.3 -2.0 -2.1 1.3 0.2 -0.9 -1.2 0.2 -0.7 0.2 0.5 -0.4
Number of live births 0.3 0.4 1.2 1.1 0.9 0.7 0.7 -0.2 0.3 -0.1 0.1 -0.0 -0.5 1.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 1.5 -0.8 -1.0 0.7 1.2 -0.1 0.1 0.3 0.8 -0.5 0.6 0.8
Pulse rate 1.7 2.8 9.2 -0.4 0.4 -1.6 -0.5 1.5 3.0 3.0 -0.1 1.7 1.4 -1.6
Happiness 1.9 2.3 8.3 -0.6 -0.5 0.1 -2.9 -1.2 0.4 1.1 -2.0 1.3 0.4 -2.7
Noisy workplace 0.5 0.6 1.7 -0.5 -1.3 1.3 -0.6 0.2 -0.7 -0.2 -1.0 -0.2 -0.8 -0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.1 0.1 -0.8 0.2 0.9 -0.3 -0.7 -0.7 0.2 -1.0 -0.8 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.6 1.2 0.9 -1.6 0.5 -0.6 0.5 0.5 0.5 0.6 0.2 -0.0
Mouth/teeth dental problems: Dentures 0.4 0.6 3.0 1.1 0.1 -0.5 0.7 -1.7 0.0 -1.1 0.3 0.4 0.8 -0.2
Asthma 1.0 2.0 6.5 2.5 0.9 -1.2 1.8 -0.5 0.3 -1.5 1.4 -1.5 -1.4 1.2
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 5.2 -0.5 -1.4 0.5 -1.6 -1.1 -0.2 1.0 -1.0 2.1 2.3 -1.0
Medication: Cholesterol lowering 1.4 2.2 6.2 2.5 2.4 -1.1 1.4 0.2 0.1 -1.1 1.4 -1.7 -1.5 0.7
Depression (self-reported) 1.1 1.3 4.5 1.0 -1.0 -2.1 0.6 -1.9 -0.5 -1.6 0.9 -0.6 0.2 0.3
Medication: Lansoprazole 0.4 0.4 1.1 0.1 0.6 -0.9 -1.0 -0.5 0.2 1.0 -0.2 0.6 0.4 -0.6
Prospective memory result 0.3 0.3 1.0 0.6 -0.0 0.4 -0.2 -0.3 0.4 -0.8 -0.6 -1.0 0.0 -0.9
Lung cancer (father) 1.0 1.2 3.0 -1.7 -0.8 1.0 -1.5 0.7 0.2 1.0 -0.9 1.1 1.3 -1.1
Illnesses of mother 1.2 1.4 3.9 -0.4 -0.7 -0.2 -2.0 0.2 1.0 0.1 -1.3 1.5 1.7 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.9 -1.4 -1.2 1.3 1.2 -0.6 -0.8 -0.7 0.3 -1.3 0.3 0.2
Pulse wave Arterial Stiffness index 0.6 0.7 2.7 0.6 1.1 0.4 0.1 -1.5 -0.6 -0.4 -0.1 -0.8 -1.6 0.4
Impedance of arm (left) 1.0 4.8 13.6 0.2 0.7 -2.1 -0.2 2.7 1.4 3.7 1.7 3.5 2.6 1.5
Arm fat mass (right) 0.2 0.9 3.5 1.9 -0.2 -0.2 1.3 -0.1 -0.5 0.2 1.5 -0.0 -0.2 1.2
Trunk predicted mass 0.7 4.1 14.5 0.4 -0.5 2.1 1.0 -1.6 -2.0 -3.8 -0.9 -3.5 -2.0 -0.3
Standing height 0.0 0.5 1.9 0.4 -0.4 0.4 -0.1 0.7 -0.8 -1.4 -0.0 -0.2 1.3 0.2
Length of working week for main job 0.7 0.8 2.8 0.4 0.7 -0.9 1.7 0.9 -0.6 -0.7 1.3 -0.9 0.4 0.9
Exposure to tobacco smoke at home 0.7 0.7 2.0 0.1 -0.6 1.4 1.2 -1.2 -0.5 -1.0 -0.6 -1.1 -0.4 0.1
Breastfed as a baby 1.3 1.6 5.6 -0.4 -1.5 0.2 -0.3 1.9 1.3 2.4 -0.8 1.1 0.4 -1.4
Tense / ‘highly strung’ 0.6 0.9 3.8 1.1 0.9 -1.2 0.3 -1.9 0.1 -1.4 0.5 0.2 -0.2 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 9.3 1.1 0.4 -0.2 -0.5 -3.0 -0.5 -1.9 -0.2 -0.7 -0.9 -0.1
Hair/balding pattern: Pattern 4 1.0 2.5 4.3 1.4 1.6 -0.7 1.1 2.0 1.4 1.8 2.1 1.9 1.8 0.8
Birth weight of first child 1.0 1.8 6.7 0.5 -1.4 -0.5 -0.5 0.6 0.9 1.6 1.0 2.6 2.4 0.0
Peak expiratory flow (PEF) 0.8 1.8 4.0 -0.4 -1.9 -0.3 1.1 1.6 -0.3 1.8 1.8 1.2 2.0 0.8
Pulse wave reflection index 0.9 1.1 4.1 0.1 0.6 0.4 1.3 -0.2 -2.0 -0.5 1.0 -1.0 -1.1 1.5
Ever highly irritable/argumentative for 2 days 0.6 0.8 4.1 -2.0 0.2 1.3 -0.6 -0.0 -0.8 0.3 -1.1 0.0 -0.2 -0.2
Loud music exposure frequency 1.1 1.2 3.4 -0.2 -0.8 0.7 0.5 -1.9 -1.8 -1.6 0.4 -1.2 -1.0 -0.5
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.7 -0.7 0.7 1.5 0.7 -0.0 -0.9 -0.4 0.1 -1.9 -1.9 0.3
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 6.1 2.4 -0.0 -2.5 0.8 -0.7 0.3 0.1 1.9 1.0 1.5 0.5
Blood clot in the leg (DVT) 0.3 0.4 1.3 -1.0 -0.1 -0.7 -0.0 -1.1 -0.9 0.1 0.2 0.1 0.8 -0.1
Medication: Paracetamol 1.3 2.1 7.2 0.8 0.1 -1.9 0.1 0.5 1.0 2.5 0.7 2.7 2.1 -0.1
Headache pain in last month 0.9 1.6 4.3 1.6 1.0 -2.1 -0.4 -1.1 1.7 1.4 0.4 1.7 0.5 0.2
Medication for cholesterol, blood pressure or diabetes 1.6 2.7 8.2 -2.1 -2.4 -0.0 -0.9 0.9 -0.1 2.0 -0.5 2.9 2.2 -0.4
Glaucoma (self-reported) 0.2 0.3 1.2 -0.4 -0.2 0.3 1.1 0.0 0.4 0.3 0.7 -0.3 0.8 0.3
Gout (self-reported) 3.5 4.8 12.5 -3.2 -1.5 3.5 -1.1 -1.9 -1.2 -1.4 -3.0 -1.9 -2.4 -1.2
Hypothyroidism/myxoedema (self-reported) 2.3 4.5 13.6 2.5 -0.1 0.3 0.5 -3.0 -2.4 -3.7 -0.1 -2.8 -2.6 0.7
Medication: Amlodipine 0.8 1.1 3.5 1.2 1.2 -0.2 0.2 -0.6 1.1 -0.7 -0.0 -1.6 -1.9 1.0
Medication: Ventolin 100micrograms inhaler 0.8 1.1 3.3 0.7 0.4 -1.2 1.8 1.0 0.3 0.5 1.6 0.5 0.8 1.1
Birth weight 1.3 2.7 9.4 2.5 1.8 -3.1 1.0 0.9 2.0 0.8 1.2 1.4 1.2 0.4
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.0 0.6 0.8 1.0 -0.2 -0.8 -0.4 -0.4 -0.1 -0.6 -0.9 0.2
High blood pressure (siblings) 0.6 0.9 3.2 0.0 0.0 -0.2 1.4 -0.3 -0.9 -0.9 -0.0 -1.7 -1.8 0.6
Forced vital capacity (FVC), Best measure 0.3 1.0 3.6 -0.5 -0.1 1.0 1.3 -0.7 -0.8 -1.7 0.1 -1.9 -0.3 0.2
Body fat percentage 0.7 2.9 6.4 2.1 -0.6 -1.8 0.8 0.9 0.4 2.2 2.4 2.5 1.6 1.5
Leg fat percentage (right) 0.7 2.6 6.4 1.8 -0.9 -1.7 0.9 0.7 -0.4 1.8 2.5 2.3 1.4 1.8
Arm fat-free mass (right) 0.6 2.9 10.6 0.5 -0.6 1.4 0.8 -1.8 -1.5 -3.3 -0.8 -3.1 -1.6 -0.8
Exposure to tobacco smoke outside home 1.4 1.8 4.4 0.4 -0.8 -2.1 1.8 0.7 -0.6 0.9 1.9 1.9 1.3 1.2
Comparative body size at age 10 1.1 2.9 8.2 1.2 0.3 1.6 1.5 -1.3 -1.7 -2.0 0.3 -2.9 -2.7 1.0
Number of full brothers 0.3 0.3 1.1 -0.7 -0.4 -1.0 0.4 -0.8 -0.1 -1.0 -0.0 -0.0 -0.3 0.1
Worry too long after embarrassment 2.8 4.7 13.2 0.7 1.4 -2.4 0.1 0.9 3.6 2.7 1.6 3.1 3.1 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 7.2 0.7 0.1 -0.1 -0.1 -2.7 -0.7 -1.6 -1.0 -1.0 -1.0 -0.6
Wheeze or whistling in the chest in last year 1.8 3.3 8.6 1.9 2.1 -0.9 2.9 0.2 -0.6 -1.5 2.3 -1.6 -1.4 2.5
Number of children fathered 1.6 1.8 5.5 -1.9 -0.0 1.0 -2.3 1.2 1.0 1.2 -1.6 1.0 1.0 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 3.3 -1.8 -1.6 -0.1 -1.4 0.3 0.9 0.3 -1.6 1.0 0.9 -1.1
Age at first live birth 0.9 1.5 5.3 -0.6 -0.1 1.5 -1.0 0.7 -0.2 -1.0 -1.3 -2.3 -0.9 -2.0
Pulse wave peak to peak time 0.6 0.7 2.8 -0.5 -1.1 -0.4 -0.2 1.4 0.6 0.2 0.1 0.8 1.7 -0.4
Health satisfaction 1.0 1.3 5.1 2.3 1.5 -1.7 -0.5 -1.1 1.0 0.6 0.6 1.0 0.4 -0.1
Shortness of breath walking on level ground 1.3 1.5 3.4 1.8 1.3 -0.5 1.7 -1.5 1.2 -0.4 1.5 0.1 -0.4 1.5
Qualifications: College or University degree 0.3 0.9 2.8 -0.3 0.1 -1.5 0.4 0.9 0.7 1.0 1.7 0.8 1.0 1.0
Eye problems/disorders: None of the above 0.3 0.3 1.7 -0.7 -0.2 1.3 -0.7 -0.2 -0.1 -0.3 -0.8 -0.1 -0.3 -0.1
Mouth/teeth dental problems: Loose teeth 1.7 2.0 5.4 1.6 1.6 -0.9 2.3 1.1 0.4 1.0 1.9 1.0 -0.8 1.9
Emphysema/chronic bronchitis 0.8 0.8 3.2 -0.1 1.0 0.7 -0.6 0.1 -0.1 -0.9 -1.2 -1.8 -1.4 0.1
Medication for pain relief, constipation, heartburn 0.4 0.6 2.4 -1.5 0.6 0.8 0.4 1.1 0.2 -0.8 0.5 -1.0 -0.5 0.3
Neck or shoulder pain in last month 0.5 0.7 1.9 1.1 -1.0 -0.9 -0.6 -1.1 -0.6 -0.3 -0.9 -0.7 0.0 -1.4
Medication: Blood pressure 1.3 2.2 7.6 1.3 1.4 0.7 0.1 -2.0 0.2 -2.0 -0.5 -2.8 -2.1 -0.1
Angina (self-reported) 1.7 2.3 6.9 1.4 0.4 0.1 0.9 -2.0 -1.5 -2.6 0.3 -2.3 -1.9 -0.2
Migraine (self-reported) 1.4 1.7 4.5 1.7 1.4 -1.1 2.1 -1.5 0.7 -0.1 1.5 0.4 -0.5 1.6
Medication: Ibuprofen 1.2 1.5 4.3 -0.1 -1.0 0.1 -1.6 -1.4 -0.4 0.4 -1.2 1.9 2.1 -1.1
Medication: Allopurinol 1.5 2.1 6.4 -1.4 -0.8 1.9 -1.9 -1.3 -0.1 -0.7 -2.5 -0.8 -1.1 -1.5
Medication: Omeprazole 0.3 0.3 1.6 -0.3 -0.4 -0.1 -1.3 -0.5 -0.4 0.3 -0.6 0.3 0.3 -0.7
Medication: Seretide 50 evohaler 0.4 0.5 1.8 -0.1 -0.0 -0.3 -0.9 0.9 0.6 1.0 -0.2 -0.6 0.2 -1.4
Mean time to correctly identify matches 0.2 0.4 1.4 0.6 -0.7 0.2 -0.6 0.3 0.1 0.1 -0.8 1.2 1.2 -0.5
Heart disease (mother) 0.4 0.5 1.9 1.4 -0.5 -0.3 0.8 -0.5 -0.1 0.2 0.9 0.1 -0.4 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 4.3 0.1 -1.5 -0.1 -1.5 0.4 1.0 0.8 -1.5 0.2 0.2 -2.1
Whole body fat mass 0.2 0.9 3.1 1.8 -0.6 -0.8 0.9 0.1 -0.3 0.6 1.6 0.8 0.7 1.0
Leg fat mass (right) 0.2 0.9 3.3 1.8 -0.7 -0.8 1.1 -0.2 -0.6 0.0 1.5 0.4 0.1 1.1
Arm predicted mass (right) 0.5 2.7 10.5 0.6 -0.8 1.3 0.9 -1.7 -1.5 -3.2 -0.7 -2.8 -1.5 -0.5
Pulse rate, automated reading 2.3 7.4 20.8 0.5 -0.4 -3.7 -1.7 2.5 3.8 4.6 0.6 3.2 2.9 -2.1
Alcohol intake frequency. 0.2 0.5 1.4 1.0 0.7 -0.9 0.6 0.1 1.0 0.6 1.2 0.0 -0.2 0.0
Comparative height size at age 10 0.5 2.8 5.7 -2.0 -2.4 1.3 -2.2 0.9 0.6 0.5 -1.7 0.7 2.4 -2.0
Number of full sisters 0.9 1.1 3.2 1.4 0.1 -1.5 1.8 -0.2 -0.2 -0.3 1.7 0.6 0.0 1.1
Suffer from ‘nerves’ 0.9 1.5 3.5 0.7 -0.2 -1.9 -0.9 -1.4 1.5 1.2 -0.1 1.7 1.4 -0.8
Overall health rating 0.8 1.7 5.3 1.8 1.8 -2.3 0.2 -2.2 1.0 -0.1 0.8 0.2 -0.6 0.1
Chest pain or discomfort 0.6 0.9 2.2 1.1 0.6 -1.0 -0.3 -1.0 0.8 -1.1 -0.9 -1.5 -1.2 -0.7
Had major operations 0.4 0.5 2.1 -0.5 -1.0 -0.1 -0.4 -1.4 0.2 0.3 -0.9 1.0 0.5 -0.0
Age at last live birth 0.8 1.2 5.7 -0.7 -0.2 2.4 0.1 1.4 -0.9 -0.8 0.1 -1.7 -0.7 -0.0
Family relationship satisfaction 0.8 0.9 3.4 0.1 -1.0 -0.4 -1.6 -0.7 -0.7 -0.7 -1.3 0.1 0.2 -1.8
Leg pain on walking 0.8 1.0 2.1 1.4 0.9 0.2 1.4 0.6 -0.9 -0.7 1.0 -0.7 -1.0 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.7 1.5 -0.2 -1.2 -0.4 -1.6 0.2 -0.3 0.7 0.9 1.1 0.7
Commuting to job workplace: Car/motor vehicle 1.6 1.8 6.8 0.9 1.0 -1.9 -0.1 1.5 1.7 1.4 0.5 2.6 0.4 0.1
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 7.1 -2.3 -1.4 2.7 -1.3 1.1 -1.4 0.1 -1.3 -0.8 0.7 -1.0
Medication: Aspirin 1.1 1.5 6.4 2.5 0.3 -0.8 0.8 -0.9 -0.7 -1.2 0.5 -1.5 -1.6 0.5
Supplements: Vitamin C 0.4 0.5 1.3 0.7 1.2 0.3 0.4 0.0 1.0 0.5 0.0 0.9 -0.4 1.0
Knee pain experienced in last month 0.3 0.5 2.3 -0.3 0.5 -0.2 -0.5 0.9 0.4 1.5 0.1 1.1 0.6 0.2
Hypertension (Self-reported) 2.6 7.3 27.9 1.9 0.8 1.2 0.7 -3.2 -0.7 -4.3 -1.1 -5.3 -4.1 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.6 -0.2 0.2 -0.6 -0.7 0.2 0.3 0.1 0.0 -0.8 -0.4 -0.4
Illnesses of father: Heart disease 0.5 0.7 2.2 0.0 1.2 -0.7 1.5 -0.1 0.7 0.5 0.2 -1.2 -1.1 0.3
Illnesses of siblings: Diabetes 0.6 0.8 2.6 -0.3 -1.0 -0.8 -0.2 -0.4 0.1 1.1 0.8 1.3 1.6 -0.6
Smoking status: Previous 0.4 0.6 1.9 -0.6 -0.6 0.9 -1.4 -0.0 0.5 -0.1 -1.4 0.7 0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 2.1 -0.7 0.3 1.5 0.4 0.3 -0.2 -0.5 0.5 -1.3 0.6 -0.2
Whole body fat-free mass 0.7 3.9 12.9 0.5 -0.6 2.1 1.0 -1.7 -1.6 -3.6 -0.8 -3.6 -2.1 -0.4
Leg fat-free mass (right) 0.8 4.1 15.1 0.5 -0.1 2.5 1.4 -1.7 -0.9 -3.1 -0.7 -3.9 -2.8 -0.3
Arm fat percentage (left) 0.3 1.2 4.0 1.6 -0.1 -0.7 1.3 0.6 0.0 1.3 2.0 0.5 0.2 1.4
Average weekly red wine intake 0.4 0.6 2.2 1.1 0.5 -0.3 0.9 -0.1 -0.3 -0.9 0.4 0.7 -0.5 1.5
Handedness (chirality/laterality): Left-handed 1.2 1.4 3.6 -1.8 -0.7 0.2 0.3 1.7 0.8 1.6 0.4 1.4 1.9 0.1
Mood swings 0.7 1.2 2.8 1.5 1.5 -0.7 -1.1 -1.7 -0.6 -0.5 -0.6 -0.8 -1.2 -1.1
Loneliness, isolation 0.1 0.2 0.5 0.6 -0.1 0.1 -0.6 -0.7 0.2 -0.5 -0.3 0.0 0.6 -0.3
Long-standing illness, disability or infirmity 1.3 1.9 4.8 2.2 2.0 -0.7 1.6 -0.9 0.9 -1.1 1.0 -0.8 -1.5 1.7
Ever had bowel cancer screening 1.4 1.6 3.6 0.7 1.9 0.5 1.5 0.7 1.3 1.1 1.3 1.6 0.6 1.7
Diabetes diagnosed by doctor 0.6 1.1 3.6 1.9 1.2 -1.0 1.2 -0.4 0.8 -0.1 1.1 0.4 -1.0 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.7 -0.5 0.6 0.8 -0.8 0.8 0.6 0.4 -0.3 -0.1 -0.3 -0.3
Friendships satisfaction 1.5 1.9 4.9 0.1 -1.3 -1.4 -2.2 -1.0 -0.1 0.6 -1.2 1.7 1.3 -2.2
Qualifications: nursing, teaching 0.3 0.5 1.8 -0.2 -0.8 -0.8 0.0 0.4 -0.6 -0.0 -1.0 -0.7 -0.6 -1.3
Commuting to job workplace: Walk 1.0 1.1 2.6 0.6 0.6 1.1 0.4 -1.3 -1.1 -1.2 -0.3 -1.6 -1.5 1.0
Eye problems/disorders: Cataract 0.4 0.4 1.5 -0.0 0.3 0.2 -0.8 -0.7 0.9 0.3 -0.8 0.2 0.4 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.9 0.1 -0.8 -0.1 0.4 -0.8 0.2 0.3 0.8 0.5 0.9 0.9
Medication for cholesterol 3.0 4.6 12.9 -0.5 -0.1 -2.0 -0.1 3.0 1.1 3.0 0.9 3.6 3.5 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 0.3 0.8 0.2 0.8 -0.1 -0.2 -0.5 0.3 0.4 -0.4 0.7
Back pain experienced in last month 1.0 1.4 5.2 0.2 0.3 -1.2 -1.3 0.7 0.3 1.8 -0.5 2.3 1.6 -0.7
Mineral and other dietary supplements 0.6 0.9 4.3 0.8 0.5 -0.9 1.4 0.0 -0.4 0.3 2.1 0.0 -0.2 1.0
Breast cancer (self-reported) 0.7 0.8 2.2 0.2 -1.1 -0.3 -0.4 1.2 0.4 1.5 0.1 1.4 1.0 -0.6
Asthma (self-reported) 0.9 1.8 6.1 2.5 1.1 -1.1 1.8 -0.2 0.3 -1.1 1.5 -1.3 -1.2 1.3
Osteoporosis (self-reported) 1.1 1.4 5.1 0.7 0.5 0.9 0.6 -1.7 -0.6 -1.4 -0.9 -1.3 -2.3 0.6
Osteoarthritis (self-reported) 1.7 2.2 4.3 -1.6 -0.1 -0.1 -1.8 2.0 2.1 1.9 -0.9 1.2 1.8 -1.0
Medication: Aspirin 0.7 0.9 3.7 1.9 0.4 -0.8 0.8 -0.5 -0.0 -0.6 0.5 -1.3 -1.4 0.6
Medication: Gliclazide 1.1 1.2 4.0 0.7 -0.4 -0.4 0.7 1.0 0.5 2.0 1.2 1.8 1.5 0.2
Illnesses of father: None of the above (group 1) 1.3 1.6 5.0 -0.8 -1.2 0.3 -1.9 1.0 -0.2 0.4 -0.9 1.3 2.2 -1.7
Smoking status: Current 2.0 3.2 8.8 2.5 1.6 -1.4 0.5 -0.0 0.1 1.5 2.5 3.0 2.1 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 2.2 -1.5 -0.2 1.2 -0.3 -0.4 -0.1 0.3 -0.7 -0.8 0.0 -0.9
Whole body water mass 0.7 4.2 14.1 0.5 -0.7 2.2 0.9 -1.8 -1.7 -3.7 -0.9 -3.8 -2.2 -0.5
Leg predicted mass (right) 0.7 3.9 14.3 0.6 -0.1 2.3 1.4 -1.7 -0.8 -3.1 -0.7 -3.8 -2.7 -0.3
Arm fat mass (left) 0.2 0.7 2.9 1.7 -0.2 -0.2 1.3 -0.2 -0.4 0.0 1.4 -0.3 -0.3 0.9
Number of self-reported non-cancer illnesses 1.8 3.1 14.6 3.8 2.4 -2.1 0.6 -1.7 1.4 -1.0 1.1 -0.3 -1.1 1.2
Average weekly champagne plus white wine intake 0.3 0.4 1.7 -1.3 -0.3 1.2 0.1 0.6 -0.6 -0.1 -0.1 -0.2 -0.4 0.3
Miserableness 0.5 0.8 3.5 1.2 0.3 -1.9 -0.2 -1.6 -0.1 -0.2 0.1 1.1 0.6 0.4
Guilty feelings 0.8 1.2 3.7 1.4 1.9 -1.4 -0.7 -1.9 0.8 -0.7 0.2 0.7 0.2 0.4
Wears glasses or contact lenses 1.0 1.1 4.6 0.8 0.1 -0.3 0.2 0.7 0.7 1.3 1.3 1.6 2.2 0.5
Ever taken oral contraceptive pill 1.4 1.6 5.6 1.4 1.3 -0.9 1.7 1.2 0.5 0.4 2.4 0.0 0.2 1.6
Hearing aid user 0.3 0.3 1.7 0.7 1.3 0.0 -0.2 -0.2 0.4 -0.6 0.6 -0.1 -0.3 0.4
Mother’s age at death 0.5 0.7 2.3 -1.3 -0.3 0.3 1.1 0.6 0.0 1.5 0.1 1.2 0.4 0.2
Financial situation satisfaction 1.1 1.4 3.2 0.7 1.6 0.5 0.3 -1.4 -1.5 -1.5 0.3 -1.1 -1.8 0.8
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.9 -1.2 0.2 0.3 1.1 1.7 0.6 0.7 0.9 -0.2 -0.6 1.0
Commuting to job workplace: Public transport 0.7 0.8 1.9 -0.9 -0.9 0.9 1.1 0.3 -0.1 1.0 1.4 0.1 0.6 1.4
Eye problems/disorders: Glaucoma 0.3 0.3 1.1 -0.5 -0.3 0.7 0.0 0.1 0.2 0.8 0.0 0.8 1.1 0.1
Medication: Blood pressure 2.6 5.0 16.2 1.4 0.6 1.9 0.6 -2.5 -1.0 -2.8 -0.6 -3.7 -4.0 1.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 2.7 0.9 0.2 0.2 0.5 0.7 0.1 0.6 1.0 1.6 1.0 1.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.8 -0.9 -0.0 0.8 -0.6 0.6 0.1 -0.8 -1.3 -0.6 -0.3 -0.1
High cholesterol (Self-reported) 1.5 2.7 6.9 1.7 2.6 -0.3 2.0 -0.5 0.7 -1.5 1.6 -1.7 -2.0 1.6
Medication: Bendroflumethiazide 2.0 3.0 7.3 1.4 1.5 1.3 2.2 -0.3 -0.1 -1.5 0.9 -2.6 -2.7 2.2
Medication: Paracetamol 2.0 3.1 9.3 0.7 0.4 -1.9 0.7 1.3 1.8 3.1 1.2 3.0 2.3 0.3
Medication: Lisinopril 1.3 1.7 4.9 -0.8 0.3 1.4 0.4 -1.4 -1.0 -1.5 -0.9 -2.2 -2.1 0.3
Medication: Atorvastatin 0.5 0.6 1.6 -0.5 -0.3 0.7 -0.3 -0.8 -0.8 -0.7 -0.9 -1.2 -1.0 -0.4
Illnesses of father: High blood pressure 2.1 2.6 9.1 0.6 0.6 0.8 0.8 -2.4 -2.1 -1.8 -0.5 -1.4 -3.0 1.4
Alcohol drinker status: Never 0.7 0.8 2.3 0.1 -0.3 1.3 0.6 -0.8 -0.7 -0.9 -0.2 -1.3 -1.5 1.0
Ever smoked 0.7 1.2 3.9 1.6 0.3 -1.4 -0.6 0.0 0.3 0.3 0.8 2.0 1.7 0.6
Basal metabolic rate 0.5 2.8 9.4 0.8 -0.5 1.8 1.1 -1.4 -1.5 -3.0 -0.3 -3.1 -1.8 -0.1
Leg fat percentage (left) 0.5 1.9 4.9 1.5 -1.0 -1.5 0.5 0.2 -0.3 1.6 1.9 2.2 1.2 1.4
Arm fat-free mass (left) 0.6 2.8 10.8 0.9 -0.7 1.1 0.5 -1.8 -1.8 -3.3 -0.7 -2.8 -1.7 -0.7
Number of operations (self-reported) 1.1 1.7 7.4 1.5 0.1 -2.7 0.5 -0.8 0.9 0.8 1.1 1.8 1.3 0.3
Average weekly beer plus cider intake 0.4 0.5 1.6 -1.3 -1.1 0.5 0.0 -0.7 -1.1 -0.1 -0.5 -0.7 -0.1 -0.5
Irritability 1.1 1.9 6.4 1.0 1.3 -2.5 0.1 0.9 0.8 1.4 1.4 2.0 1.1 0.9
Risk taking 1.3 1.9 4.0 1.2 1.2 -0.3 1.3 -2.0 -0.7 -1.8 1.3 -1.0 -1.7 1.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 4.6 0.7 2.1 0.4 -0.7 1.9 1.1 1.2 0.2 0.7 0.6 -0.0
Fractured/broken bones in last 5 years 0.8 1.0 4.6 1.5 1.0 -2.1 0.2 -0.9 0.7 -0.7 0.3 0.9 0.9 0.1
Age started oral contraceptive pill 0.5 0.6 1.2 0.7 -0.8 -1.1 -0.7 -1.0 0.3 -1.1 -1.0 0.1 -0.2 -0.8
Diastolic blood pressure, automated reading 4.0 12.3 48.4 -1.5 -1.6 2.4 -1.1 -3.6 -2.1 -4.0 -3.2 -7.0 -5.4 -1.2
Ever depressed for a whole week 0.2 0.3 1.1 -0.3 0.2 -0.9 -0.2 -1.1 0.7 -0.6 -0.4 0.1 -0.1 -0.0
Unable to work because of sickness or disability 0.4 0.5 2.5 -0.1 -0.0 -1.0 -0.5 -1.6 -0.2 -0.1 -0.8 0.5 -0.2 -0.8
Commuting to job workplace: Cycle 0.3 0.4 1.4 -0.3 -1.0 -0.3 -0.6 -0.4 0.0 -0.1 -0.4 0.3 1.0 -1.2
Myopia 1.2 1.8 4.9 0.9 -0.7 -0.9 1.6 0.3 1.2 1.3 1.6 2.2 1.7 1.1
Vascular/heart problems diagnosed by doctor 3.8 10.3 38.3 -1.7 -0.6 -1.7 -0.4 3.9 1.4 5.1 1.7 6.2 4.9 -0.2
Cholesterol lowering medication 0.9 1.4 3.3 0.6 0.5 1.0 0.5 -1.7 -0.4 -1.6 0.1 -1.8 -1.6 1.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.7 -0.1 -0.1 0.0 -0.4 -0.8 -0.4 0.3 0.2 -0.0 -0.1 0.2
Pain experienced in last month 0.6 1.1 2.5 -1.4 -0.2 1.6 1.0 0.4 -0.3 -1.4 0.5 -1.0 -1.2 1.1
Supplements: Calcium 0.9 1.0 3.2 1.8 1.1 -0.4 0.9 -0.7 1.7 -0.3 0.9 0.2 -0.4 1.2
Basal cell carcinoma (self-reported) 0.8 1.0 2.2 0.4 0.9 -0.3 1.0 -1.4 1.5 -0.0 0.3 1.5 0.4 1.5
Heart attack/myocardial infarction (self-reported) 2.0 2.6 5.6 0.1 -0.7 1.3 -1.6 -2.4 -1.9 -1.7 -1.9 -1.7 -1.2 -2.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 -1.1 -0.1 -0.9 -0.1 -0.8 -0.9 0.4 0.3 0.1 1.0 -0.4
Heart disease (siblings) 1.4 1.8 4.5 0.1 -0.9 0.0 -1.0 -2.1 -0.7 -1.3 -2.0 -1.2 -1.0 -2.1
Alcohol drinker status: Previous 2.8 3.2 7.2 0.9 0.8 -1.9 1.4 0.4 1.7 2.1 2.4 2.7 2.7 0.3
Pack years of smoking 0.9 1.3 3.3 1.0 1.8 -0.1 1.6 -0.8 -1.4 -0.7 1.1 0.0 -0.9 1.3
Impedance of whole body 1.6 8.4 28.6 0.0 0.2 -3.7 -0.9 2.6 1.1 4.4 2.0 5.3 4.0 1.3
Leg fat mass (left) 0.2 0.7 2.5 1.6 -0.7 -0.6 0.9 -0.5 -0.5 0.0 1.2 0.5 0.0 0.9
Arm predicted mass (left) 0.4 2.1 8.1 0.8 -0.5 0.9 0.8 -1.3 -1.5 -2.9 -0.4 -2.5 -1.5 -0.4