Hub : Genes

SWAP70

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1900	0.0440	4.5e-13	0.069	0.139	0.127	0.129	0.130	8.4e-09	1.5e-16	3.1e-15	1.8e-15	1.6e-15
2	GTEx	Artery Aorta	0.1420	0.0600	1.6e-03	0.013	NA	0.079	NA	0.060	5.7e-02	NA	3.7e-05	NA	3.2e-04
3	GTEx	Cells EBV-transformed lymphocytes	0.3690	0.0780	3.6e-07	0.308	NA	0.265	NA	0.299	1.0e-10	NA	3.3e-09	NA	2.3e-10
4	GTEx	Lung	0.0771	0.0318	1.2e-03	0.059	NA	0.023	NA	0.042	2.8e-05	NA	6.3e-03	NA	3.8e-04
5	GTEx	Nerve Tibial	0.1799	0.0611	2.1e-03	0.036	NA	0.123	NA	0.111	1.4e-03	NA	5.0e-09	NA	3.1e-08
6	GTEx	Skin Not Sun Exposed Suprapubic	0.3790	0.0870	2.9e-05	0.034	NA	0.062	NA	0.057	5.5e-03	NA	2.5e-04	NA	4.4e-04
7	GTEx	Skin Sun Exposed Lower leg	0.1670	0.0450	4.7e-07	0.049	NA	0.097	NA	0.100	6.7e-05	NA	2.0e-08	NA	1.3e-08
8	ROSMAP	Brain Pre-frontal Cortex	0.0519	0.0232	6.0e-04	0.034	0.021	0.032	0.025	0.038	2.7e-05	9.7e-04	4.7e-05	3.1e-04	1.1e-05
9	YFS	Blood	0.0853	0.0211	1.1e-16	0.072	0.066	0.077	0.079	0.079	1.7e-22	9.5e-21	4.7e-24	1.5e-24	1.9e-24
10	TCGA	Pancreatic Adenocarcinoma	0.1670	0.0900	3.1e-03	0.023	0.058	0.055	NA	0.020	3.7e-02	1.9e-03	2.5e-03	NA	4.9e-02
11	TCGA	Prostate Adenocarcinoma	0.0399	0.0261	6.7e-03	0.007	0.014	0.005	NA	0.009	5.3e-02	1.2e-02	9.0e-02	NA	3.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.8	1.3	3.2	-1.8	-1.3	0.8	0.3	-0.4	-1.1	-1.0	-0.9	-1.7	-1.4	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.5	2.1	-0.3	-0.2	0.4	0.6	0.3	-1.0	-0.7	0.2	-1.4	-1.1	0.4
Depressed Affect (Nagel 2018)	0.7	1.5	4.6	2.1	1.1	-1.6	-2.0	-1.5	0.4	0.0	-0.7	0.3	0.0	-1.3
Depression (Nagel 2018)	0.4	0.6	2.2	1.1	0.2	-1.2	-0.9	-1.5	-0.0	-0.2	-0.7	0.6	-0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.2	0.9	-0.1	-0.2	0.5	-1.1	-0.2	-0.6	0.5	0.5	0.3	0.6
Neuroticism (Nagel 2018)	1.3	3.0	7.1	2.3	1.5	-2.7	-1.7	-1.1	2.2	1.2	-0.0	2.3	1.5	-0.4
Schizophrenia (2018)	0.2	0.5	1.1	1.0	0.7	-0.2	0.5	0.7	-0.4	-0.0	1.0	-0.5	-0.4	1.0
Schizophrenia vs Biploar Disorder	0.7	0.9	4.0	-0.6	1.1	2.0	-0.9	0.8	1.2	0.7	-0.8	0.4	0.7	-0.2
Worry (Nagel 2018)	1.0	2.0	5.4	1.2	1.3	-1.9	-1.1	-1.2	2.3	1.0	0.1	2.2	1.4	0.2
Alzheimer’s Disease (in mother)	1.6	1.8	4.4	0.4	0.1	-1.4	-1.1	1.1	1.8	1.7	0.1	1.8	2.1	-1.4
Alzheimer’s Disease (in father)	0.7	0.8	2.5	0.7	-1.3	-0.9	-0.2	-0.8	-0.1	0.2	0.3	1.6	1.6	-0.3
Alzheimer’s Disease (including proxy)	2.3	3.3	8.2	0.8	-0.7	-2.5	-1.1	0.8	2.3	2.0	0.1	2.9	2.6	-1.5
Crohns Disease (2017)	0.9	1.9	8.7	-0.6	0.5	-0.2	-1.3	0.7	3.0	1.9	0.3	1.0	2.1	-0.1
Irritable Bowel Disease (IBD)	0.7	1.6	4.1	1.1	2.0	-0.5	0.1	1.7	1.7	0.8	1.5	0.3	1.5	0.9
Ulcerative Colitis (UC)	1.1	2.1	5.7	2.3	2.4	-0.6	1.3	1.6	-0.5	-0.8	2.1	-0.6	0.5	1.6
Major Depression (MDD)	0.1	0.2	0.6	-0.8	0.8	-0.2	-0.2	-0.2	0.2	0.0	0.2	-0.1	0.0	0.6
Reaction Time	0.1	0.3	0.9	0.7	0.2	0.3	0.1	-0.8	-0.9	-0.9	-0.3	0.0	0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	0.7	1.2	-0.4	1.2	-0.7	-0.3	-0.5	0.7	0.2	-1.1	1.4
Breast Cancer	2.0	4.8	11.2	2.8	3.4	0.0	2.2	-1.0	-1.1	-2.1	1.1	-2.3	-3.0	2.4
Ovarian Cancer	1.2	1.6	9.5	0.8	-1.4	-0.9	-0.6	-3.1	-0.1	-1.6	-0.6	-0.7	-0.9	-0.3
Prostate Cancer	3.1	4.3	11.7	0.6	1.6	-1.7	-1.0	1.9	2.8	3.4	1.4	2.7	2.9	-0.3
Age at First Birth	1.3	1.9	4.4	1.2	-0.5	1.1	-1.6	-1.3	-1.4	-1.2	-2.1	-1.1	-1.7	-1.5
Bipolar Disorder (2011)	0.9	0.8	2.8	-0.0	-0.7	0.8	0.3	-1.4	-1.7	-1.3	-0.7	-0.8	-0.5	-0.6
Body Mass Index (BMI) (2010)	1.6	2.2	6.4	-1.2	-1.1	1.1	-2.2	1.4	1.4	1.0	-1.7	-0.9	0.6	-2.5
Coronary Artery Disease (CAD)	2.7	3.2	7.7	0.1	-1.6	0.6	-1.0	-2.8	-2.4	-2.8	-1.2	-2.5	-1.5	-0.2
Crohns Disease (2012)	0.4	0.6	2.9	0.0	-0.5	0.5	-0.7	-1.7	1.1	-0.5	-0.4	-0.9	-0.6	0.2
Mean Putamen Volume	2.6	3.0	6.1	-1.0	-0.8	2.1	-0.7	-1.7	-2.4	-2.2	-1.6	-2.5	-1.9	-0.5
Fasting Glucose	0.4	0.4	1.6	0.7	1.2	0.8	0.3	-0.4	0.8	-0.4	0.2	-0.3	-0.8	0.4
HbA1C	3.6	3.9	14.5	0.3	-1.1	-2.2	0.0	1.9	2.1	2.8	1.8	2.0	3.8	-0.1
HDL Cholesterol	0.6	1.0	3.9	0.6	-0.9	-1.7	0.6	-1.5	-0.3	-0.0	0.4	2.0	0.4	0.6
LDL Cholesterol	1.3	2.1	8.0	-0.6	-1.5	1.9	-0.4	1.2	-1.4	1.0	0.0	1.9	2.8	0.2
Lupus	0.4	0.6	2.5	-0.2	-0.8	-0.8	0.1	1.6	0.0	0.3	-0.0	0.8	1.5	0.2
Neuroticism (2016)	1.7	2.5	8.5	0.7	0.3	-2.3	-0.1	0.7	2.9	2.9	1.0	1.5	1.0	-0.0
Primary Biliary Cirrhosis	0.7	1.0	4.1	0.4	0.1	-0.5	0.8	2.0	0.0	1.3	1.5	1.1	0.9	0.6
Rheumatoid Arthritis	3.6	4.9	12.4	0.2	1.1	2.2	1.4	-1.8	-2.5	-3.3	-0.3	-3.4	-3.5	1.6
Schizophrenia (2014)	0.1	0.3	1.2	1.1	0.7	-0.4	0.5	0.4	-0.1	0.0	0.5	0.1	-0.2	0.7
Triglycerides	0.5	0.8	2.9	-0.2	-0.1	1.7	-1.0	1.5	0.2	-0.0	-1.3	-0.5	0.4	-0.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	5.4	1.0	1.7	-0.0	2.3	1.3	0.6	0.7	1.5	-0.5	-0.8	1.4
Ulcerative Colitis	1.0	1.5	2.9	1.6	1.5	-0.4	1.0	1.5	-1.6	-0.7	1.7	-0.8	0.1	1.3
Blood Eosinophil Count	0.2	1.9	11.4	-0.3	0.0	1.8	0.6	3.4	1.4	0.1	0.2	0.7	1.8	0.5
Blood Platelet Count	1.0	12.1	36.8	-1.4	0.1	-1.8	-0.7	6.1	4.5	5.6	2.0	4.1	4.1	-0.8
Blood Red Count	0.8	7.8	31.4	-2.8	-3.8	0.2	-4.7	-0.5	-5.6	-1.5	-1.8	-1.0	0.4	-1.9
Blood White Count	1.1	8.3	25.4	2.9	3.5	-0.5	4.1	0.6	-0.6	-2.0	3.4	-1.2	-3.3	5.0
Heel T-Score	0.6	5.1	12.8	0.5	-2.2	-3.4	0.3	2.4	0.5	2.9	2.2	3.6	2.7	0.5
BMI	0.1	0.5	1.5	1.0	-0.7	0.4	0.0	-0.5	0.2	-1.2	-0.0	-1.1	-0.7	-0.0
Height	0.1	1.5	7.0	1.7	-0.0	-0.9	0.2	1.5	-1.2	-0.9	1.0	0.7	2.6	0.2
Waist Hip Ratio (WHR)	2.0	8.8	24.7	2.0	0.6	-3.3	1.3	1.6	1.8	4.1	3.8	5.0	3.7	2.0
Systolic Blood Pressure	7.3	36.5	153.8	-2.7	-0.4	5.6	0.0	-4.8	-3.5	-7.4	-4.8	-12.4	-9.8	-0.1
Smoking Status	0.6	1.5	6.1	1.5	1.2	0.1	-0.2	-0.4	0.6	0.6	0.9	2.5	2.0	1.1
Allergy or Eczema	0.5	1.4	4.6	0.9	0.6	-0.1	1.3	0.1	-0.6	0.6	1.6	2.2	1.1	1.8
Cardiovascular Disease	6.0	19.8	67.1	2.5	2.7	1.2	1.8	-5.3	-1.3	-6.9	-0.8	-8.2	-7.2	1.5
Hypothyroidism (self reported)	2.3	5.2	18.1	1.8	-0.2	0.8	0.0	-2.6	-2.9	-4.2	-0.5	-3.6	-2.7	0.5
Respiratory disease	0.3	0.6	2.9	1.7	0.7	-0.4	0.6	0.1	1.0	-0.5	0.7	-0.8	-0.8	0.5
Type 2 Diabetes (T2D) (2018)	1.1	2.0	5.4	2.3	1.3	-1.7	1.3	0.1	1.8	0.7	1.7	1.5	-0.0	1.3
Lung FEV1/FVC ratio	1.1	5.3	15.4	-2.6	-3.9	0.6	0.3	2.5	0.4	3.0	1.4	2.3	3.6	0.8
Lung FVC	0.2	0.9	3.5	-0.6	0.7	0.3	0.6	-0.9	0.8	-0.4	-1.0	-1.9	-1.4	-0.8
Neuroticism	1.4	3.3	9.9	1.9	1.6	-3.2	-0.6	-1.0	2.0	1.5	1.0	2.7	1.9	0.5
Chronotype (morning person)	0.3	0.6	2.8	-0.2	0.9	1.7	-0.7	1.2	-0.7	-0.1	-0.8	-0.4	0.3	-0.1
Hair Pigment	0.1	2.5	7.8	0.7	1.1	1.4	1.0	-0.9	-0.9	-2.8	-0.6	-2.1	-2.8	1.0
Tanning	0.1	1.1	4.0	-2.0	-0.8	0.7	-1.4	0.3	0.9	0.7	-1.1	0.6	0.9	-1.1
Hand grip strength (left)	0.2	0.4	1.0	-0.2	-0.4	-0.4	-1.0	1.0	-0.0	-0.4	-0.4	-0.3	0.9	-1.0
Number of treatments/medications taken	1.0	1.7	4.0	1.9	2.0	0.6	0.8	-1.5	1.1	-1.6	0.0	-1.3	-1.2	1.0
Average weekly spirits intake	0.5	0.6	3.2	-0.6	-0.5	1.8	-0.9	-0.0	-0.3	0.3	-1.1	-0.2	-0.6	-0.9
Sensitivity / hurt feelings	1.5	2.6	6.1	1.9	2.0	-2.5	0.3	0.0	1.2	1.3	1.6	2.1	2.0	1.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.3	0.3	-0.5	-0.2	-1.1	0.6	-0.1	-1.0	0.3	-0.6	-0.4
Hearing difficulty/problems: Yes	0.5	0.8	2.6	-1.1	-1.6	0.7	0.1	-1.1	-0.8	-1.2	-0.3	-0.5	-0.5	0.6
Relative age of first facial hair	0.2	0.4	1.0	-1.0	0.4	-0.1	0.7	0.7	-0.5	-0.7	0.0	-1.0	-0.6	0.6
Other serious medical condition/disability diagnosed by doctor	1.7	2.1	4.9	1.5	1.4	-0.8	2.0	1.2	1.7	1.0	2.0	0.6	-0.0	2.2
Ever used hormone-replacement therapy (HRT)	1.3	1.6	7.4	0.3	-0.7	-0.8	-0.1	-0.5	1.6	1.1	0.4	2.7	2.2	0.5
Ever had hysterectomy (womb removed)	1.0	1.1	2.8	-0.5	-1.6	0.5	-1.4	-0.8	0.3	0.6	-0.8	1.4	1.7	-1.0
Systolic blood pressure, automated reading	4.3	12.4	50.0	-2.5	-1.6	3.7	-1.7	-1.8	-1.3	-2.8	-4.1	-7.1	-5.3	-1.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	0.2	1.3	-0.4	1.0	0.7	0.9	0.2	0.2	-0.3	-0.9	0.3
Angina	1.6	2.1	6.1	1.5	0.2	-0.0	0.9	-1.9	-1.4	-2.5	0.2	-2.2	-1.8	-0.4
Medication for hormone replacement therapy	0.3	0.3	1.2	-0.7	-0.3	1.1	0.1	-0.0	0.9	-0.0	0.0	0.2	0.3	0.6
Vitamin and mineral supplements	0.3	0.4	1.0	-0.7	-0.5	0.4	0.6	0.4	-0.9	0.4	0.8	-0.4	1.0	-0.0
Supplements: Zinc	0.4	0.4	1.3	1.2	0.4	-0.0	0.9	-0.1	-0.2	-0.9	-0.2	0.1	-1.1	0.7
Medication: Co-codamol	0.3	0.3	0.9	0.2	-0.3	0.9	-0.4	0.4	0.2	1.0	0.2	0.6	0.9	0.4
Medication: Metformin	0.1	0.2	0.6	0.1	0.7	0.2	0.5	0.1	-0.2	-0.3	-0.0	-0.8	-0.8	0.1
Diabetes (father)	2.0	2.5	5.1	1.8	1.6	-2.3	2.0	0.7	1.2	1.4	1.7	1.4	-0.9	1.9
Diabetes (mother)	0.6	0.8	3.5	0.4	0.3	-0.6	1.9	-0.5	-0.5	-0.2	0.8	0.1	-1.4	1.2
Severe depression (siblings)	0.6	0.7	3.0	-0.8	-0.1	0.2	-0.1	-0.5	-0.2	-1.2	-1.2	-0.7	-1.7	0.1
Pack years adult smoking proportion	1.5	2.3	6.1	0.8	2.4	-0.2	2.5	-0.7	-1.5	-0.6	1.9	-0.0	-1.1	2.2
Impedance of leg (right)	2.0	9.9	36.1	0.2	-0.3	-3.9	-1.0	2.7	0.4	4.1	2.4	6.0	4.9	1.4
Leg fat-free mass (left)	0.6	3.2	12.4	1.1	0.1	1.9	1.6	-1.2	-0.9	-2.8	-0.1	-3.5	-2.4	0.0
Trunk fat percentage	0.9	3.5	8.4	2.2	-0.2	-2.0	0.8	1.1	0.8	2.6	2.5	2.9	1.8	1.5
Hand grip strength (right)	0.3	0.7	2.3	-0.3	-0.6	0.2	-1.5	-0.5	0.1	-0.8	-1.3	0.0	0.9	-1.4
Townsend deprivation index at recruitment	0.6	0.9	2.6	0.5	-1.6	-0.6	0.3	-1.5	-1.1	0.0	1.1	0.8	1.0	0.4
Current tobacco smoking	1.9	3.0	7.8	2.4	1.2	-1.7	0.4	-0.3	0.0	1.4	2.6	2.8	2.3	1.2
Average weekly fortified wine intake	1.4	1.7	3.8	0.0	-1.4	-1.6	-1.6	0.2	0.3	1.1	-0.3	1.6	1.9	-2.0
Maternal smoking around birth	1.0	1.4	6.8	-0.1	0.9	1.1	0.0	-2.6	-0.6	-1.8	0.2	-0.5	-1.1	1.1
Fed-up feelings	0.5	0.9	3.0	0.9	1.2	-1.0	-1.7	-1.6	0.1	0.5	-0.4	0.7	0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	0.3	-0.5	-0.8	-1.0	-1.3	0.3	0.4	-0.8	1.0	0.3	-0.7
Relative age voice broke	0.6	0.9	3.0	0.6	1.7	-1.4	1.0	0.4	1.0	0.0	1.0	0.3	0.3	1.4
Taking other prescription medications	0.4	0.6	2.7	1.6	0.7	-0.6	-0.4	-1.5	0.2	-0.4	-0.3	0.3	0.1	0.1
Age when periods started (menarche)	0.5	1.2	3.2	-1.5	-1.2	1.8	-1.0	-1.1	-0.3	-1.1	-1.6	0.3	-0.3	-0.4
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.5	2.3	-0.5	-2.3	0.5	0.3	0.4	1.3	2.0	2.3	1.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	10.8	-0.7	-1.5	-0.7	0.3	3.3	0.0	2.5	1.0	0.0	0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	3.5	-0.7	-0.1	0.9	-0.2	0.2	-1.0	-1.4	-0.9	-1.9	-0.8	-0.3
Qualifications: CSEs or equivalent	0.9	1.2	3.3	0.1	1.0	-1.1	1.7	0.3	-0.2	0.9	1.8	-0.4	-1.0	1.4
Serious illness, injury or assault to yourself	0.4	0.5	2.5	0.4	0.0	-1.1	-0.8	-0.3	0.1	0.2	-0.6	-0.5	-0.6	-1.6
High blood pressure	3.2	9.0	32.8	1.9	0.6	1.4	0.7	-3.7	-0.9	-4.6	-1.3	-5.7	-4.7	0.7
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.9	1.2	0.8	-0.2	1.3	0.1	-1.1	0.7	2.0	2.4	1.5	1.8
Multivitamins +/- minerals	0.3	0.4	2.0	-0.1	0.2	0.1	-0.1	-0.1	1.4	0.0	-0.7	-0.1	-1.3	0.2
Stomach or abdominal pain in last month	0.4	0.4	2.3	0.8	1.5	-0.5	0.7	-0.2	-0.4	-0.3	0.4	-0.7	-0.4	0.3
Supplements: Glucosamine	1.1	1.4	4.2	-0.5	-0.3	-0.3	-1.2	0.8	1.0	1.9	-0.3	1.9	2.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	6.8	1.1	0.6	-2.6	-0.1	-0.1	0.2	0.3	0.5	0.6	-0.1	-0.1
Medication: Atenolol	1.7	2.1	6.1	0.9	1.2	1.2	1.4	-1.3	-1.1	-1.8	0.1	-2.2	-2.5	1.1
Medication: Levothyroxine sodium	1.9	3.1	7.1	2.1	0.7	-0.3	1.2	-1.9	-1.7	-2.5	0.7	-2.7	-2.3	1.5
Sitting height	0.6	4.3	13.0	3.6	-1.6	-3.4	-1.4	-1.9	-2.4	-2.5	-0.5	-0.3	0.4	-1.5
Chronic bronchitis/emphysema (father)	3.4	4.0	8.8	1.5	1.4	-2.2	1.4	1.4	3.0	2.1	2.8	2.4	0.7	1.8
High blood pressure (mother)	2.3	3.3	11.7	-0.2	0.9	1.0	2.0	-1.1	-1.1	-1.5	0.7	-2.7	-3.4	2.5
Body mass index (BMI)	0.2	0.8	2.2	1.5	-0.4	0.4	1.1	-1.0	-0.7	-0.7	0.7	-1.0	-1.2	0.4
Impedance of leg (left)	1.8	8.9	37.0	-0.6	-0.7	-3.5	-1.6	2.0	0.5	4.0	1.4	6.1	4.8	0.8
Leg predicted mass (left)	0.6	3.2	12.2	1.0	-0.0	2.0	1.5	-1.2	-0.9	-2.8	-0.2	-3.5	-2.3	-0.0
Trunk fat mass	0.4	1.7	4.5	2.1	-0.3	-1.3	1.0	0.6	0.2	1.3	2.1	1.6	1.0	1.3
Waist circumference	0.2	0.8	3.7	1.9	-0.1	-0.3	1.1	-0.1	0.2	0.1	1.4	0.7	0.1	1.3
Number of incorrect matches in round	1.0	1.7	5.2	0.9	-1.8	-0.7	-1.7	-0.2	-0.1	-0.5	-2.2	0.7	0.2	-2.3
Past tobacco smoking	0.4	0.7	3.4	-1.0	-0.7	0.3	0.7	-0.0	-0.9	-0.4	0.0	-1.9	-1.3	-0.3
Alcohol usually taken with meals	0.2	0.4	1.4	0.6	0.2	-0.8	-1.2	0.6	0.6	-0.4	-0.6	-0.4	-0.2	-0.6
Nervous feelings	1.2	2.2	7.0	2.0	-0.2	-2.7	-0.8	-1.5	1.3	0.7	0.2	2.2	1.8	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.4	1.1	0.9	-1.5	1.1	-1.5	0.1	0.0	0.7	0.4	-0.3	0.6
Hearing difficulty/problems with background noise	0.4	0.7	3.9	-0.3	-2.0	-0.4	-0.4	-1.3	-1.0	-0.8	-0.2	-0.1	0.5	0.0
Hair/balding pattern: Pattern 2	1.7	2.2	5.0	2.1	-0.2	-1.9	-0.5	-2.2	-0.9	-1.9	-0.1	-1.6	-1.8	-0.2
Had menopause	0.4	0.5	2.0	0.2	-0.8	-0.9	0.2	-0.8	0.9	-0.2	-0.2	1.4	0.5	0.1
Had other major operations	0.6	0.7	3.5	0.4	-0.0	-1.9	0.8	0.5	0.7	1.2	0.5	0.9	0.6	-0.2
Forced vital capacity (FVC)	0.1	0.3	1.4	-0.1	-0.5	0.7	0.7	-0.5	-0.3	-0.8	0.0	-1.2	-0.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	8.4	-0.6	-1.1	0.1	0.5	2.9	0.7	2.3	1.0	0.3	0.4	0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	-0.8	-0.7	-1.3	-1.0	-0.7	0.8	-0.3	-0.5	0.7	1.1	-1.1
Qualifications: None of the above	0.7	1.6	3.3	1.5	-0.9	-0.9	-1.8	-1.8	-0.9	-1.1	-1.1	0.7	1.4	-1.2
Financial difficulties in last 2 years	0.7	0.9	3.6	1.2	-0.2	-1.4	0.2	-1.9	0.9	-1.0	-0.3	1.1	-0.3	0.4
Mouth/teeth dental problems	1.1	1.8	5.2	-2.3	-0.4	1.7	-1.5	1.7	-0.5	0.5	-1.9	-0.8	-0.9	-0.8
Heart attack	2.2	2.8	5.4	0.1	-0.5	1.3	-1.5	-2.3	-2.0	-2.0	-1.9	-1.9	-1.4	-2.0
Allergy	0.5	1.2	3.0	-1.7	-0.6	1.5	-0.6	-0.2	1.2	-0.5	-1.6	-1.2	-0.8	-0.7
Pain all over the body in last month	0.9	0.9	2.6	0.1	-0.5	0.6	-0.1	-0.0	-1.5	-0.9	-0.9	-1.6	-1.6	-0.6
Diabetes (self-reported)	0.4	0.6	1.4	1.1	0.7	-1.1	0.7	-0.2	1.2	0.4	0.7	0.6	-0.8	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.7	-0.2	0.6	-1.1	0.4	-0.5	0.6	-0.9	0.8	-0.0	-0.1
Medication: Ramipril	1.3	1.7	5.0	1.2	2.2	1.2	1.1	-0.5	0.8	-1.2	0.2	-1.5	-1.5	1.6
Medication: Simvastatin	2.2	3.3	12.2	3.5	2.2	-1.7	1.5	-0.6	-0.4	-1.6	1.7	-1.8	-1.8	1.3
Fluid intelligence score	0.4	0.8	2.3	0.2	1.1	-0.1	1.4	0.3	-0.3	-0.8	1.4	-0.4	-0.1	1.5
Illnesses of siblings	1.0	1.4	5.3	-0.8	0.3	1.1	-0.3	2.3	1.1	1.5	0.7	1.2	1.6	0.2
Neuroticism score	1.3	2.7	9.2	1.8	1.5	-3.0	-0.7	-1.2	1.5	1.2	0.6	2.4	1.7	0.3
Weight	0.2	0.8	2.7	1.6	-0.5	0.4	1.0	-0.6	-0.8	-1.1	0.7	-1.0	-0.5	0.5
Impedance of arm (right)	1.1	5.3	16.7	0.4	0.7	-2.2	-0.2	2.8	1.2	3.8	1.7	4.1	2.5	1.8
Arm fat percentage (right)	0.4	1.4	4.5	1.8	-0.3	-0.8	1.3	0.5	-0.1	1.3	2.1	0.8	0.3	1.5
Trunk fat-free mass	0.7	4.1	14.7	0.4	-0.7	2.2	0.8	-1.7	-2.1	-3.8	-0.9	-3.5	-2.0	-0.4
Hip circumference	0.3	1.5	3.4	1.0	-0.0	1.4	0.9	-0.5	-1.3	-1.8	0.0	-1.8	-1.8	0.9
Time employed in main current job	1.5	1.7	4.6	2.2	1.2	-1.4	-1.0	0.3	1.9	1.0	0.4	1.4	1.8	-0.1
Alcohol intake versus 10 years previously	2.1	3.1	8.4	-1.1	-0.4	1.9	1.1	-1.1	-1.8	-2.6	-0.7	-2.9	-2.8	0.7
Father’s age at death	0.5	0.7	1.8	1.3	-0.3	-0.1	0.1	0.6	0.6	1.2	1.2	1.4	0.8	0.1
Worrier / anxious feelings	0.7	1.3	3.9	0.5	1.1	-1.5	-1.1	-1.4	2.0	0.6	-0.3	1.6	0.9	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	7.5	2.7	1.7	-1.2	1.2	-2.3	0.9	-0.7	1.3	0.1	-0.5	1.1
Falls in the last year	1.9	2.6	6.1	2.5	2.0	-1.7	2.1	1.2	0.8	1.0	1.9	1.1	0.3	1.9
Hair/balding pattern: Pattern 3	0.8	1.2	4.3	-2.0	-2.1	1.3	0.2	-0.9	-1.2	0.2	-0.7	0.2	0.5	-0.4
Number of live births	0.3	0.4	1.2	1.1	0.9	0.7	0.7	-0.2	0.3	-0.1	0.1	-0.0	-0.5	1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.5	-0.8	-1.0	0.7	1.2	-0.1	0.1	0.3	0.8	-0.5	0.6	0.8
Pulse rate	1.7	2.8	9.2	-0.4	0.4	-1.6	-0.5	1.5	3.0	3.0	-0.1	1.7	1.4	-1.6
Happiness	1.9	2.3	8.3	-0.6	-0.5	0.1	-2.9	-1.2	0.4	1.1	-2.0	1.3	0.4	-2.7
Noisy workplace	0.5	0.6	1.7	-0.5	-1.3	1.3	-0.6	0.2	-0.7	-0.2	-1.0	-0.2	-0.8	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.1	-0.8	0.2	0.9	-0.3	-0.7	-0.7	0.2	-1.0	-0.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.6	1.2	0.9	-1.6	0.5	-0.6	0.5	0.5	0.5	0.6	0.2	-0.0
Mouth/teeth dental problems: Dentures	0.4	0.6	3.0	1.1	0.1	-0.5	0.7	-1.7	0.0	-1.1	0.3	0.4	0.8	-0.2
Asthma	1.0	2.0	6.5	2.5	0.9	-1.2	1.8	-0.5	0.3	-1.5	1.4	-1.5	-1.4	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	5.2	-0.5	-1.4	0.5	-1.6	-1.1	-0.2	1.0	-1.0	2.1	2.3	-1.0
Medication: Cholesterol lowering	1.4	2.2	6.2	2.5	2.4	-1.1	1.4	0.2	0.1	-1.1	1.4	-1.7	-1.5	0.7
Depression (self-reported)	1.1	1.3	4.5	1.0	-1.0	-2.1	0.6	-1.9	-0.5	-1.6	0.9	-0.6	0.2	0.3
Medication: Lansoprazole	0.4	0.4	1.1	0.1	0.6	-0.9	-1.0	-0.5	0.2	1.0	-0.2	0.6	0.4	-0.6
Prospective memory result	0.3	0.3	1.0	0.6	-0.0	0.4	-0.2	-0.3	0.4	-0.8	-0.6	-1.0	0.0	-0.9
Lung cancer (father)	1.0	1.2	3.0	-1.7	-0.8	1.0	-1.5	0.7	0.2	1.0	-0.9	1.1	1.3	-1.1
Illnesses of mother	1.2	1.4	3.9	-0.4	-0.7	-0.2	-2.0	0.2	1.0	0.1	-1.3	1.5	1.7	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.9	-1.4	-1.2	1.3	1.2	-0.6	-0.8	-0.7	0.3	-1.3	0.3	0.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.7	0.6	1.1	0.4	0.1	-1.5	-0.6	-0.4	-0.1	-0.8	-1.6	0.4
Impedance of arm (left)	1.0	4.8	13.6	0.2	0.7	-2.1	-0.2	2.7	1.4	3.7	1.7	3.5	2.6	1.5
Arm fat mass (right)	0.2	0.9	3.5	1.9	-0.2	-0.2	1.3	-0.1	-0.5	0.2	1.5	-0.0	-0.2	1.2
Trunk predicted mass	0.7	4.1	14.5	0.4	-0.5	2.1	1.0	-1.6	-2.0	-3.8	-0.9	-3.5	-2.0	-0.3
Standing height	0.0	0.5	1.9	0.4	-0.4	0.4	-0.1	0.7	-0.8	-1.4	-0.0	-0.2	1.3	0.2
Length of working week for main job	0.7	0.8	2.8	0.4	0.7	-0.9	1.7	0.9	-0.6	-0.7	1.3	-0.9	0.4	0.9
Exposure to tobacco smoke at home	0.7	0.7	2.0	0.1	-0.6	1.4	1.2	-1.2	-0.5	-1.0	-0.6	-1.1	-0.4	0.1
Breastfed as a baby	1.3	1.6	5.6	-0.4	-1.5	0.2	-0.3	1.9	1.3	2.4	-0.8	1.1	0.4	-1.4
Tense / ‘highly strung’	0.6	0.9	3.8	1.1	0.9	-1.2	0.3	-1.9	0.1	-1.4	0.5	0.2	-0.2	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	9.3	1.1	0.4	-0.2	-0.5	-3.0	-0.5	-1.9	-0.2	-0.7	-0.9	-0.1
Hair/balding pattern: Pattern 4	1.0	2.5	4.3	1.4	1.6	-0.7	1.1	2.0	1.4	1.8	2.1	1.9	1.8	0.8
Birth weight of first child	1.0	1.8	6.7	0.5	-1.4	-0.5	-0.5	0.6	0.9	1.6	1.0	2.6	2.4	0.0
Peak expiratory flow (PEF)	0.8	1.8	4.0	-0.4	-1.9	-0.3	1.1	1.6	-0.3	1.8	1.8	1.2	2.0	0.8
Pulse wave reflection index	0.9	1.1	4.1	0.1	0.6	0.4	1.3	-0.2	-2.0	-0.5	1.0	-1.0	-1.1	1.5
Ever highly irritable/argumentative for 2 days	0.6	0.8	4.1	-2.0	0.2	1.3	-0.6	-0.0	-0.8	0.3	-1.1	0.0	-0.2	-0.2
Loud music exposure frequency	1.1	1.2	3.4	-0.2	-0.8	0.7	0.5	-1.9	-1.8	-1.6	0.4	-1.2	-1.0	-0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.7	-0.7	0.7	1.5	0.7	-0.0	-0.9	-0.4	0.1	-1.9	-1.9	0.3
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	6.1	2.4	-0.0	-2.5	0.8	-0.7	0.3	0.1	1.9	1.0	1.5	0.5
Blood clot in the leg (DVT)	0.3	0.4	1.3	-1.0	-0.1	-0.7	-0.0	-1.1	-0.9	0.1	0.2	0.1	0.8	-0.1
Medication: Paracetamol	1.3	2.1	7.2	0.8	0.1	-1.9	0.1	0.5	1.0	2.5	0.7	2.7	2.1	-0.1
Headache pain in last month	0.9	1.6	4.3	1.6	1.0	-2.1	-0.4	-1.1	1.7	1.4	0.4	1.7	0.5	0.2
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	8.2	-2.1	-2.4	-0.0	-0.9	0.9	-0.1	2.0	-0.5	2.9	2.2	-0.4
Glaucoma (self-reported)	0.2	0.3	1.2	-0.4	-0.2	0.3	1.1	0.0	0.4	0.3	0.7	-0.3	0.8	0.3
Gout (self-reported)	3.5	4.8	12.5	-3.2	-1.5	3.5	-1.1	-1.9	-1.2	-1.4	-3.0	-1.9	-2.4	-1.2
Hypothyroidism/myxoedema (self-reported)	2.3	4.5	13.6	2.5	-0.1	0.3	0.5	-3.0	-2.4	-3.7	-0.1	-2.8	-2.6	0.7
Medication: Amlodipine	0.8	1.1	3.5	1.2	1.2	-0.2	0.2	-0.6	1.1	-0.7	-0.0	-1.6	-1.9	1.0
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.3	0.7	0.4	-1.2	1.8	1.0	0.3	0.5	1.6	0.5	0.8	1.1
Birth weight	1.3	2.7	9.4	2.5	1.8	-3.1	1.0	0.9	2.0	0.8	1.2	1.4	1.2	0.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	0.6	0.8	1.0	-0.2	-0.8	-0.4	-0.4	-0.1	-0.6	-0.9	0.2
High blood pressure (siblings)	0.6	0.9	3.2	0.0	0.0	-0.2	1.4	-0.3	-0.9	-0.9	-0.0	-1.7	-1.8	0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	3.6	-0.5	-0.1	1.0	1.3	-0.7	-0.8	-1.7	0.1	-1.9	-0.3	0.2
Body fat percentage	0.7	2.9	6.4	2.1	-0.6	-1.8	0.8	0.9	0.4	2.2	2.4	2.5	1.6	1.5
Leg fat percentage (right)	0.7	2.6	6.4	1.8	-0.9	-1.7	0.9	0.7	-0.4	1.8	2.5	2.3	1.4	1.8
Arm fat-free mass (right)	0.6	2.9	10.6	0.5	-0.6	1.4	0.8	-1.8	-1.5	-3.3	-0.8	-3.1	-1.6	-0.8
Exposure to tobacco smoke outside home	1.4	1.8	4.4	0.4	-0.8	-2.1	1.8	0.7	-0.6	0.9	1.9	1.9	1.3	1.2
Comparative body size at age 10	1.1	2.9	8.2	1.2	0.3	1.6	1.5	-1.3	-1.7	-2.0	0.3	-2.9	-2.7	1.0
Number of full brothers	0.3	0.3	1.1	-0.7	-0.4	-1.0	0.4	-0.8	-0.1	-1.0	-0.0	-0.0	-0.3	0.1
Worry too long after embarrassment	2.8	4.7	13.2	0.7	1.4	-2.4	0.1	0.9	3.6	2.7	1.6	3.1	3.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	7.2	0.7	0.1	-0.1	-0.1	-2.7	-0.7	-1.6	-1.0	-1.0	-1.0	-0.6
Wheeze or whistling in the chest in last year	1.8	3.3	8.6	1.9	2.1	-0.9	2.9	0.2	-0.6	-1.5	2.3	-1.6	-1.4	2.5
Number of children fathered	1.6	1.8	5.5	-1.9	-0.0	1.0	-2.3	1.2	1.0	1.2	-1.6	1.0	1.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.3	-1.8	-1.6	-0.1	-1.4	0.3	0.9	0.3	-1.6	1.0	0.9	-1.1
Age at first live birth	0.9	1.5	5.3	-0.6	-0.1	1.5	-1.0	0.7	-0.2	-1.0	-1.3	-2.3	-0.9	-2.0
Pulse wave peak to peak time	0.6	0.7	2.8	-0.5	-1.1	-0.4	-0.2	1.4	0.6	0.2	0.1	0.8	1.7	-0.4
Health satisfaction	1.0	1.3	5.1	2.3	1.5	-1.7	-0.5	-1.1	1.0	0.6	0.6	1.0	0.4	-0.1
Shortness of breath walking on level ground	1.3	1.5	3.4	1.8	1.3	-0.5	1.7	-1.5	1.2	-0.4	1.5	0.1	-0.4	1.5
Qualifications: College or University degree	0.3	0.9	2.8	-0.3	0.1	-1.5	0.4	0.9	0.7	1.0	1.7	0.8	1.0	1.0
Eye problems/disorders: None of the above	0.3	0.3	1.7	-0.7	-0.2	1.3	-0.7	-0.2	-0.1	-0.3	-0.8	-0.1	-0.3	-0.1
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.4	1.6	1.6	-0.9	2.3	1.1	0.4	1.0	1.9	1.0	-0.8	1.9
Emphysema/chronic bronchitis	0.8	0.8	3.2	-0.1	1.0	0.7	-0.6	0.1	-0.1	-0.9	-1.2	-1.8	-1.4	0.1
Medication for pain relief, constipation, heartburn	0.4	0.6	2.4	-1.5	0.6	0.8	0.4	1.1	0.2	-0.8	0.5	-1.0	-0.5	0.3
Neck or shoulder pain in last month	0.5	0.7	1.9	1.1	-1.0	-0.9	-0.6	-1.1	-0.6	-0.3	-0.9	-0.7	0.0	-1.4
Medication: Blood pressure	1.3	2.2	7.6	1.3	1.4	0.7	0.1	-2.0	0.2	-2.0	-0.5	-2.8	-2.1	-0.1
Angina (self-reported)	1.7	2.3	6.9	1.4	0.4	0.1	0.9	-2.0	-1.5	-2.6	0.3	-2.3	-1.9	-0.2
Migraine (self-reported)	1.4	1.7	4.5	1.7	1.4	-1.1	2.1	-1.5	0.7	-0.1	1.5	0.4	-0.5	1.6
Medication: Ibuprofen	1.2	1.5	4.3	-0.1	-1.0	0.1	-1.6	-1.4	-0.4	0.4	-1.2	1.9	2.1	-1.1
Medication: Allopurinol	1.5	2.1	6.4	-1.4	-0.8	1.9	-1.9	-1.3	-0.1	-0.7	-2.5	-0.8	-1.1	-1.5
Medication: Omeprazole	0.3	0.3	1.6	-0.3	-0.4	-0.1	-1.3	-0.5	-0.4	0.3	-0.6	0.3	0.3	-0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.8	-0.1	-0.0	-0.3	-0.9	0.9	0.6	1.0	-0.2	-0.6	0.2	-1.4
Mean time to correctly identify matches	0.2	0.4	1.4	0.6	-0.7	0.2	-0.6	0.3	0.1	0.1	-0.8	1.2	1.2	-0.5
Heart disease (mother)	0.4	0.5	1.9	1.4	-0.5	-0.3	0.8	-0.5	-0.1	0.2	0.9	0.1	-0.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.3	0.1	-1.5	-0.1	-1.5	0.4	1.0	0.8	-1.5	0.2	0.2	-2.1
Whole body fat mass	0.2	0.9	3.1	1.8	-0.6	-0.8	0.9	0.1	-0.3	0.6	1.6	0.8	0.7	1.0
Leg fat mass (right)	0.2	0.9	3.3	1.8	-0.7	-0.8	1.1	-0.2	-0.6	0.0	1.5	0.4	0.1	1.1
Arm predicted mass (right)	0.5	2.7	10.5	0.6	-0.8	1.3	0.9	-1.7	-1.5	-3.2	-0.7	-2.8	-1.5	-0.5
Pulse rate, automated reading	2.3	7.4	20.8	0.5	-0.4	-3.7	-1.7	2.5	3.8	4.6	0.6	3.2	2.9	-2.1
Alcohol intake frequency.	0.2	0.5	1.4	1.0	0.7	-0.9	0.6	0.1	1.0	0.6	1.2	0.0	-0.2	0.0
Comparative height size at age 10	0.5	2.8	5.7	-2.0	-2.4	1.3	-2.2	0.9	0.6	0.5	-1.7	0.7	2.4	-2.0
Number of full sisters	0.9	1.1	3.2	1.4	0.1	-1.5	1.8	-0.2	-0.2	-0.3	1.7	0.6	0.0	1.1
Suffer from ‘nerves’	0.9	1.5	3.5	0.7	-0.2	-1.9	-0.9	-1.4	1.5	1.2	-0.1	1.7	1.4	-0.8
Overall health rating	0.8	1.7	5.3	1.8	1.8	-2.3	0.2	-2.2	1.0	-0.1	0.8	0.2	-0.6	0.1
Chest pain or discomfort	0.6	0.9	2.2	1.1	0.6	-1.0	-0.3	-1.0	0.8	-1.1	-0.9	-1.5	-1.2	-0.7
Had major operations	0.4	0.5	2.1	-0.5	-1.0	-0.1	-0.4	-1.4	0.2	0.3	-0.9	1.0	0.5	-0.0
Age at last live birth	0.8	1.2	5.7	-0.7	-0.2	2.4	0.1	1.4	-0.9	-0.8	0.1	-1.7	-0.7	-0.0
Family relationship satisfaction	0.8	0.9	3.4	0.1	-1.0	-0.4	-1.6	-0.7	-0.7	-0.7	-1.3	0.1	0.2	-1.8
Leg pain on walking	0.8	1.0	2.1	1.4	0.9	0.2	1.4	0.6	-0.9	-0.7	1.0	-0.7	-1.0	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.7	1.5	-0.2	-1.2	-0.4	-1.6	0.2	-0.3	0.7	0.9	1.1	0.7
Commuting to job workplace: Car/motor vehicle	1.6	1.8	6.8	0.9	1.0	-1.9	-0.1	1.5	1.7	1.4	0.5	2.6	0.4	0.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	7.1	-2.3	-1.4	2.7	-1.3	1.1	-1.4	0.1	-1.3	-0.8	0.7	-1.0
Medication: Aspirin	1.1	1.5	6.4	2.5	0.3	-0.8	0.8	-0.9	-0.7	-1.2	0.5	-1.5	-1.6	0.5
Supplements: Vitamin C	0.4	0.5	1.3	0.7	1.2	0.3	0.4	0.0	1.0	0.5	0.0	0.9	-0.4	1.0
Knee pain experienced in last month	0.3	0.5	2.3	-0.3	0.5	-0.2	-0.5	0.9	0.4	1.5	0.1	1.1	0.6	0.2
Hypertension (Self-reported)	2.6	7.3	27.9	1.9	0.8	1.2	0.7	-3.2	-0.7	-4.3	-1.1	-5.3	-4.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.2	0.2	-0.6	-0.7	0.2	0.3	0.1	0.0	-0.8	-0.4	-0.4
Illnesses of father: Heart disease	0.5	0.7	2.2	0.0	1.2	-0.7	1.5	-0.1	0.7	0.5	0.2	-1.2	-1.1	0.3
Illnesses of siblings: Diabetes	0.6	0.8	2.6	-0.3	-1.0	-0.8	-0.2	-0.4	0.1	1.1	0.8	1.3	1.6	-0.6
Smoking status: Previous	0.4	0.6	1.9	-0.6	-0.6	0.9	-1.4	-0.0	0.5	-0.1	-1.4	0.7	0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.1	-0.7	0.3	1.5	0.4	0.3	-0.2	-0.5	0.5	-1.3	0.6	-0.2
Whole body fat-free mass	0.7	3.9	12.9	0.5	-0.6	2.1	1.0	-1.7	-1.6	-3.6	-0.8	-3.6	-2.1	-0.4
Leg fat-free mass (right)	0.8	4.1	15.1	0.5	-0.1	2.5	1.4	-1.7	-0.9	-3.1	-0.7	-3.9	-2.8	-0.3
Arm fat percentage (left)	0.3	1.2	4.0	1.6	-0.1	-0.7	1.3	0.6	0.0	1.3	2.0	0.5	0.2	1.4
Average weekly red wine intake	0.4	0.6	2.2	1.1	0.5	-0.3	0.9	-0.1	-0.3	-0.9	0.4	0.7	-0.5	1.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.6	-1.8	-0.7	0.2	0.3	1.7	0.8	1.6	0.4	1.4	1.9	0.1
Mood swings	0.7	1.2	2.8	1.5	1.5	-0.7	-1.1	-1.7	-0.6	-0.5	-0.6	-0.8	-1.2	-1.1
Loneliness, isolation	0.1	0.2	0.5	0.6	-0.1	0.1	-0.6	-0.7	0.2	-0.5	-0.3	0.0	0.6	-0.3
Long-standing illness, disability or infirmity	1.3	1.9	4.8	2.2	2.0	-0.7	1.6	-0.9	0.9	-1.1	1.0	-0.8	-1.5	1.7
Ever had bowel cancer screening	1.4	1.6	3.6	0.7	1.9	0.5	1.5	0.7	1.3	1.1	1.3	1.6	0.6	1.7
Diabetes diagnosed by doctor	0.6	1.1	3.6	1.9	1.2	-1.0	1.2	-0.4	0.8	-0.1	1.1	0.4	-1.0	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.5	0.6	0.8	-0.8	0.8	0.6	0.4	-0.3	-0.1	-0.3	-0.3
Friendships satisfaction	1.5	1.9	4.9	0.1	-1.3	-1.4	-2.2	-1.0	-0.1	0.6	-1.2	1.7	1.3	-2.2
Qualifications: nursing, teaching	0.3	0.5	1.8	-0.2	-0.8	-0.8	0.0	0.4	-0.6	-0.0	-1.0	-0.7	-0.6	-1.3
Commuting to job workplace: Walk	1.0	1.1	2.6	0.6	0.6	1.1	0.4	-1.3	-1.1	-1.2	-0.3	-1.6	-1.5	1.0
Eye problems/disorders: Cataract	0.4	0.4	1.5	-0.0	0.3	0.2	-0.8	-0.7	0.9	0.3	-0.8	0.2	0.4	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	0.1	-0.8	-0.1	0.4	-0.8	0.2	0.3	0.8	0.5	0.9	0.9
Medication for cholesterol	3.0	4.6	12.9	-0.5	-0.1	-2.0	-0.1	3.0	1.1	3.0	0.9	3.6	3.5	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.3	0.8	0.2	0.8	-0.1	-0.2	-0.5	0.3	0.4	-0.4	0.7
Back pain experienced in last month	1.0	1.4	5.2	0.2	0.3	-1.2	-1.3	0.7	0.3	1.8	-0.5	2.3	1.6	-0.7
Mineral and other dietary supplements	0.6	0.9	4.3	0.8	0.5	-0.9	1.4	0.0	-0.4	0.3	2.1	0.0	-0.2	1.0
Breast cancer (self-reported)	0.7	0.8	2.2	0.2	-1.1	-0.3	-0.4	1.2	0.4	1.5	0.1	1.4	1.0	-0.6
Asthma (self-reported)	0.9	1.8	6.1	2.5	1.1	-1.1	1.8	-0.2	0.3	-1.1	1.5	-1.3	-1.2	1.3
Osteoporosis (self-reported)	1.1	1.4	5.1	0.7	0.5	0.9	0.6	-1.7	-0.6	-1.4	-0.9	-1.3	-2.3	0.6
Osteoarthritis (self-reported)	1.7	2.2	4.3	-1.6	-0.1	-0.1	-1.8	2.0	2.1	1.9	-0.9	1.2	1.8	-1.0
Medication: Aspirin	0.7	0.9	3.7	1.9	0.4	-0.8	0.8	-0.5	-0.0	-0.6	0.5	-1.3	-1.4	0.6
Medication: Gliclazide	1.1	1.2	4.0	0.7	-0.4	-0.4	0.7	1.0	0.5	2.0	1.2	1.8	1.5	0.2
Illnesses of father: None of the above (group 1)	1.3	1.6	5.0	-0.8	-1.2	0.3	-1.9	1.0	-0.2	0.4	-0.9	1.3	2.2	-1.7
Smoking status: Current	2.0	3.2	8.8	2.5	1.6	-1.4	0.5	-0.0	0.1	1.5	2.5	3.0	2.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	2.2	-1.5	-0.2	1.2	-0.3	-0.4	-0.1	0.3	-0.7	-0.8	0.0	-0.9
Whole body water mass	0.7	4.2	14.1	0.5	-0.7	2.2	0.9	-1.8	-1.7	-3.7	-0.9	-3.8	-2.2	-0.5
Leg predicted mass (right)	0.7	3.9	14.3	0.6	-0.1	2.3	1.4	-1.7	-0.8	-3.1	-0.7	-3.8	-2.7	-0.3
Arm fat mass (left)	0.2	0.7	2.9	1.7	-0.2	-0.2	1.3	-0.2	-0.4	0.0	1.4	-0.3	-0.3	0.9
Number of self-reported non-cancer illnesses	1.8	3.1	14.6	3.8	2.4	-2.1	0.6	-1.7	1.4	-1.0	1.1	-0.3	-1.1	1.2
Average weekly champagne plus white wine intake	0.3	0.4	1.7	-1.3	-0.3	1.2	0.1	0.6	-0.6	-0.1	-0.1	-0.2	-0.4	0.3
Miserableness	0.5	0.8	3.5	1.2	0.3	-1.9	-0.2	-1.6	-0.1	-0.2	0.1	1.1	0.6	0.4
Guilty feelings	0.8	1.2	3.7	1.4	1.9	-1.4	-0.7	-1.9	0.8	-0.7	0.2	0.7	0.2	0.4
Wears glasses or contact lenses	1.0	1.1	4.6	0.8	0.1	-0.3	0.2	0.7	0.7	1.3	1.3	1.6	2.2	0.5
Ever taken oral contraceptive pill	1.4	1.6	5.6	1.4	1.3	-0.9	1.7	1.2	0.5	0.4	2.4	0.0	0.2	1.6
Hearing aid user	0.3	0.3	1.7	0.7	1.3	0.0	-0.2	-0.2	0.4	-0.6	0.6	-0.1	-0.3	0.4
Mother’s age at death	0.5	0.7	2.3	-1.3	-0.3	0.3	1.1	0.6	0.0	1.5	0.1	1.2	0.4	0.2
Financial situation satisfaction	1.1	1.4	3.2	0.7	1.6	0.5	0.3	-1.4	-1.5	-1.5	0.3	-1.1	-1.8	0.8
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.9	-1.2	0.2	0.3	1.1	1.7	0.6	0.7	0.9	-0.2	-0.6	1.0
Commuting to job workplace: Public transport	0.7	0.8	1.9	-0.9	-0.9	0.9	1.1	0.3	-0.1	1.0	1.4	0.1	0.6	1.4
Eye problems/disorders: Glaucoma	0.3	0.3	1.1	-0.5	-0.3	0.7	0.0	0.1	0.2	0.8	0.0	0.8	1.1	0.1
Medication: Blood pressure	2.6	5.0	16.2	1.4	0.6	1.9	0.6	-2.5	-1.0	-2.8	-0.6	-3.7	-4.0	1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.7	0.9	0.2	0.2	0.5	0.7	0.1	0.6	1.0	1.6	1.0	1.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	-0.9	-0.0	0.8	-0.6	0.6	0.1	-0.8	-1.3	-0.6	-0.3	-0.1
High cholesterol (Self-reported)	1.5	2.7	6.9	1.7	2.6	-0.3	2.0	-0.5	0.7	-1.5	1.6	-1.7	-2.0	1.6
Medication: Bendroflumethiazide	2.0	3.0	7.3	1.4	1.5	1.3	2.2	-0.3	-0.1	-1.5	0.9	-2.6	-2.7	2.2
Medication: Paracetamol	2.0	3.1	9.3	0.7	0.4	-1.9	0.7	1.3	1.8	3.1	1.2	3.0	2.3	0.3
Medication: Lisinopril	1.3	1.7	4.9	-0.8	0.3	1.4	0.4	-1.4	-1.0	-1.5	-0.9	-2.2	-2.1	0.3
Medication: Atorvastatin	0.5	0.6	1.6	-0.5	-0.3	0.7	-0.3	-0.8	-0.8	-0.7	-0.9	-1.2	-1.0	-0.4
Illnesses of father: High blood pressure	2.1	2.6	9.1	0.6	0.6	0.8	0.8	-2.4	-2.1	-1.8	-0.5	-1.4	-3.0	1.4
Alcohol drinker status: Never	0.7	0.8	2.3	0.1	-0.3	1.3	0.6	-0.8	-0.7	-0.9	-0.2	-1.3	-1.5	1.0
Ever smoked	0.7	1.2	3.9	1.6	0.3	-1.4	-0.6	0.0	0.3	0.3	0.8	2.0	1.7	0.6
Basal metabolic rate	0.5	2.8	9.4	0.8	-0.5	1.8	1.1	-1.4	-1.5	-3.0	-0.3	-3.1	-1.8	-0.1
Leg fat percentage (left)	0.5	1.9	4.9	1.5	-1.0	-1.5	0.5	0.2	-0.3	1.6	1.9	2.2	1.2	1.4
Arm fat-free mass (left)	0.6	2.8	10.8	0.9	-0.7	1.1	0.5	-1.8	-1.8	-3.3	-0.7	-2.8	-1.7	-0.7
Number of operations (self-reported)	1.1	1.7	7.4	1.5	0.1	-2.7	0.5	-0.8	0.9	0.8	1.1	1.8	1.3	0.3
Average weekly beer plus cider intake	0.4	0.5	1.6	-1.3	-1.1	0.5	0.0	-0.7	-1.1	-0.1	-0.5	-0.7	-0.1	-0.5
Irritability	1.1	1.9	6.4	1.0	1.3	-2.5	0.1	0.9	0.8	1.4	1.4	2.0	1.1	0.9
Risk taking	1.3	1.9	4.0	1.2	1.2	-0.3	1.3	-2.0	-0.7	-1.8	1.3	-1.0	-1.7	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.6	0.7	2.1	0.4	-0.7	1.9	1.1	1.2	0.2	0.7	0.6	-0.0
Fractured/broken bones in last 5 years	0.8	1.0	4.6	1.5	1.0	-2.1	0.2	-0.9	0.7	-0.7	0.3	0.9	0.9	0.1
Age started oral contraceptive pill	0.5	0.6	1.2	0.7	-0.8	-1.1	-0.7	-1.0	0.3	-1.1	-1.0	0.1	-0.2	-0.8
Diastolic blood pressure, automated reading	4.0	12.3	48.4	-1.5	-1.6	2.4	-1.1	-3.6	-2.1	-4.0	-3.2	-7.0	-5.4	-1.2
Ever depressed for a whole week	0.2	0.3	1.1	-0.3	0.2	-0.9	-0.2	-1.1	0.7	-0.6	-0.4	0.1	-0.1	-0.0
Unable to work because of sickness or disability	0.4	0.5	2.5	-0.1	-0.0	-1.0	-0.5	-1.6	-0.2	-0.1	-0.8	0.5	-0.2	-0.8
Commuting to job workplace: Cycle	0.3	0.4	1.4	-0.3	-1.0	-0.3	-0.6	-0.4	0.0	-0.1	-0.4	0.3	1.0	-1.2
Myopia	1.2	1.8	4.9	0.9	-0.7	-0.9	1.6	0.3	1.2	1.3	1.6	2.2	1.7	1.1
Vascular/heart problems diagnosed by doctor	3.8	10.3	38.3	-1.7	-0.6	-1.7	-0.4	3.9	1.4	5.1	1.7	6.2	4.9	-0.2
Cholesterol lowering medication	0.9	1.4	3.3	0.6	0.5	1.0	0.5	-1.7	-0.4	-1.6	0.1	-1.8	-1.6	1.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.7	-0.1	-0.1	0.0	-0.4	-0.8	-0.4	0.3	0.2	-0.0	-0.1	0.2
Pain experienced in last month	0.6	1.1	2.5	-1.4	-0.2	1.6	1.0	0.4	-0.3	-1.4	0.5	-1.0	-1.2	1.1
Supplements: Calcium	0.9	1.0	3.2	1.8	1.1	-0.4	0.9	-0.7	1.7	-0.3	0.9	0.2	-0.4	1.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.2	0.4	0.9	-0.3	1.0	-1.4	1.5	-0.0	0.3	1.5	0.4	1.5
Heart attack/myocardial infarction (self-reported)	2.0	2.6	5.6	0.1	-0.7	1.3	-1.6	-2.4	-1.9	-1.7	-1.9	-1.7	-1.2	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	-1.1	-0.1	-0.9	-0.1	-0.8	-0.9	0.4	0.3	0.1	1.0	-0.4
Heart disease (siblings)	1.4	1.8	4.5	0.1	-0.9	0.0	-1.0	-2.1	-0.7	-1.3	-2.0	-1.2	-1.0	-2.1
Alcohol drinker status: Previous	2.8	3.2	7.2	0.9	0.8	-1.9	1.4	0.4	1.7	2.1	2.4	2.7	2.7	0.3
Pack years of smoking	0.9	1.3	3.3	1.0	1.8	-0.1	1.6	-0.8	-1.4	-0.7	1.1	0.0	-0.9	1.3
Impedance of whole body	1.6	8.4	28.6	0.0	0.2	-3.7	-0.9	2.6	1.1	4.4	2.0	5.3	4.0	1.3
Leg fat mass (left)	0.2	0.7	2.5	1.6	-0.7	-0.6	0.9	-0.5	-0.5	0.0	1.2	0.5	0.0	0.9
Arm predicted mass (left)	0.4	2.1	8.1	0.8	-0.5	0.9	0.8	-1.3	-1.5	-2.9	-0.4	-2.5	-1.5	-0.4