TWAS hub - SYK

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1630	0.0600	6.3e-03	-0.003	NA	0.035	NA	0.021	5.5e-01	NA	3.2e-03	NA	1.9e-02
2	GTEx	Nerve Tibial	0.4900	0.0651	5.2e-11	0.219	NA	0.262	NA	0.293	1.7e-15	NA	1.1e-18	NA	4.8e-21
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1620	0.0560	2.3e-03	0.097	NA	0.025	NA	0.073	5.7e-06	NA	1.5e-02	NA	7.5e-05
4	GTEx	Skin Sun Exposed Lower leg	0.1580	0.0430	9.3e-05	0.145	NA	0.109	NA	0.133	5.0e-12	NA	2.7e-09	NA	3.8e-11
5	GTEx	Testis	0.2930	0.0740	7.6e-05	0.302	NA	0.272	NA	0.296	6.8e-14	NA	1.8e-12	NA	1.3e-13
6	GTEx	Thyroid	0.5390	0.0490	0.0e+00	0.417	NA	0.430	NA	0.422	3.0e-34	NA	1.2e-35	NA	7.5e-35
7	NTR	Blood	0.1002	0.0210	3.3e-13	0.053	0.056	0.062	0.069	0.062	1.4e-16	1.5e-17	3.9e-19	2.4e-21	3.8e-19
8	YFS	Blood	0.1955	0.0262	0.0e+00	0.135	0.124	0.145	0.146	0.146	5.1e-42	2.8e-38	6.0e-45	1.5e-45	2.0e-45
9	TCGA	Prostate Adenocarcinoma	0.0905	0.0339	1.3e-05	0.075	0.034	0.052	NA	0.063	3.1e-08	1.5e-04	3.4e-06	NA	3.8e-07
10	TCGA	Thyroid Carcinoma	0.1770	0.0380	2.9e-14	0.193	0.140	0.161	NA	0.175	1.9e-18	1.7e-13	2.0e-15	NA	8.6e-17

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Alzheimer’s Disease (including proxy)	5.8	8.4	20.0	-0.2	2.1	2.6	3.4	3.1	4.5	1.2	2.1	3.2	4.0
Blood Platelet Count	4.1	47.8	102.0	-4.5	-8.5	-3.8	-3.4	-10.1	-4.2	-5.6	-9.6	-9.6	-4.8
Alzheimer’s Disease (in father)	3.8	4.1	10.0	-1.6	0.7	2.3	2.9	1.5	3.2	0.3	1.1	1.8	2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.1	7.7	-0.9	-2.5	-1.6	-1.8	-2.5	-2.1	-1.5	-1.4	-2.3	-2.8
Supplements: Calcium	3.1	3.4	8.4	1.0	1.7	1.2	0.7	2.2	1.9	2.9	2.0	2.0	1.7
Exposure to tobacco smoke at home	2.7	3.0	6.0	0.5	2.1	1.3	1.5	2.5	1.1	1.7	2.1	2.3	1.1
Number of full sisters	2.5	3.0	5.4	1.2	-1.3	-2.0	-2.0	-1.5	-2.0	-1.8	-1.2	-1.6	-2.3
Medication: Bendroflumethiazide	2.5	3.7	7.8	-2.1	-1.9	1.1	1.7	-2.2	1.0	-2.6	-2.8	-1.7	1.2
Alzheimer’s Disease (in mother)	2.2	2.5	5.2	0.6	1.6	1.3	1.8	1.8	2.3	1.0	1.0	1.8	1.9
Financial situation satisfaction	2.2	2.7	4.5	1.8	0.8	1.1	0.9	2.1	1.9	1.4	1.6	2.1	2.1
Number of children fathered	2.1	2.3	5.7	1.2	2.4	0.9	0.8	1.7	1.6	1.1	1.7	1.9	1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	3.8	0.6	2.0	1.7	1.6	1.8	1.2	0.7	1.3	1.9	1.6
Hearing aid user	2.1	2.4	6.5	0.8	0.5	2.6	2.4	0.9	2.2	-0.2	0.1	0.9	2.2
Crohns Disease (2017)	2.0	4.3	14.4	3.2	1.6	0.5	0.3	2.2	-0.7	3.8	2.5	2.1	-0.3
Blood clot in the leg (DVT)	2.0	2.6	5.4	0.2	2.1	1.6	1.3	2.1	1.6	0.5	0.4	2.1	2.3
Heart disease (mother)	2.0	2.4	4.3	-1.3	-0.6	-1.9	-2.1	-1.5	-1.6	-1.6	-1.4	-1.5	-1.6
Medication: Omeprazole	1.9	2.3	4.2	1.6	1.7	1.5	1.2	1.9	0.3	1.6	1.6	2.0	1.0
Family relationship satisfaction	1.9	2.4	6.5	2.5	1.7	1.5	1.2	1.2	1.3	1.5	-0.5	1.3	1.8
Friendships satisfaction	1.9	2.4	5.3	1.9	1.9	1.0	1.0	1.4	1.5	2.3	0.8	1.4	1.7
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	5.0	0.4	2.0	1.5	1.1	2.1	1.7	0.4	0.5	2.0	2.2
LDL Cholesterol	1.8	2.8	8.3	-0.1	0.9	0.6	0.6	1.9	1.7	2.5	2.9	1.9	1.5
Knee pain experienced in last month	1.8	2.8	7.0	-0.4	-1.0	-2.7	-2.0	-1.4	-2.3	-0.3	-0.5	-1.3	-2.5
Eye problems/disorders: Cataract	1.8	2.1	3.8	0.2	-1.1	-1.9	-1.9	-1.4	-1.7	1.2	-0.4	-1.5	-2.0
Schizophrenia vs Biploar Disorder	1.7	2.3	4.0	0.9	1.3	1.7	1.2	2.0	0.8	1.9	1.3	1.9	1.7
Fasting Glucose	1.7	2.0	4.2	-0.5	-1.6	-0.2	-0.1	-1.8	-2.0	-1.7	-1.6	-1.9	-0.9
HbA1C	1.7	1.9	4.0	-1.3	-1.9	-1.2	-0.6	-1.5	-0.2	-2.0	-1.9	-1.4	-0.0
Medication for hormone replacement therapy	1.7	1.9	4.8	-0.6	-1.3	-2.1	-2.2	-1.0	-1.1	-0.9	-0.4	-1.3	-1.5
Mean Putamen Volume	1.6	1.9	5.1	-1.7	-2.2	-1.3	-0.7	-1.2	-1.6	0.1	-0.7	-1.0	-1.7
HDL Cholesterol	1.6	2.6	7.6	-0.3	-1.8	-1.0	-0.6	-2.4	-0.5	-1.2	-2.7	-2.2	-1.0
Ever used hormone-replacement therapy (HRT)	1.6	2.0	6.1	-0.8	-0.7	-2.5	-2.2	-0.7	-1.6	-0.2	-0.1	-1.1	-2.1
Ever had hysterectomy (womb removed)	1.6	1.9	4.5	0.9	2.0	0.3	0.1	2.1	1.4	-0.1	1.1	2.0	1.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	4.6	0.6	-0.3	-1.4	-1.6	-1.3	-1.9	-1.1	-0.5	-1.6	-2.1
Supplements: Glucosamine	1.6	2.1	4.5	-0.7	-1.4	-1.4	-1.4	-1.5	-1.9	-0.4	-0.9	-1.7	-2.1
Length of working week for main job	1.6	1.7	3.6	-0.7	-1.8	-0.8	-1.5	-1.6	-1.5	-0.7	-0.0	-1.9	-1.5
Number of full brothers	1.6	2.0	4.9	2.2	2.2	0.2	0.2	1.1	-0.6	2.0	1.6	1.3	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.6	0.3	0.7	1.4	1.0	1.9	1.7	0.8	1.4	1.8	1.8
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.8	1.9	1.3	1.6	1.8	1.3	0.6	1.2	0.8	1.5	1.2
Birth weight of first child	1.5	2.7	6.6	-0.7	-0.3	-2.4	-2.6	0.3	-2.2	1.4	1.3	0.2	-2.4
Ever taken oral contraceptive pill	1.5	1.7	6.1	-0.8	-0.3	-2.5	-2.1	-0.6	-1.4	-0.0	0.2	-0.8	-1.7
Relative age voice broke	1.4	2.2	4.9	-0.4	1.0	1.7	1.7	1.5	1.9	0.9	0.9	1.6	2.2
Medication: Ramipril	1.4	1.8	5.7	2.1	1.9	0.4	0.1	1.3	0.4	0.5	2.4	1.3	0.4
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.4	0.1	1.8	1.2	1.4	1.6	0.4	0.9	1.1	2.1	0.8
Emphysema/chronic bronchitis	1.4	1.6	3.1	0.7	1.7	0.9	1.5	1.7	1.1	0.8	1.0	1.7	0.9
Osteoarthritis (self-reported)	1.4	1.8	5.1	-0.0	-0.6	-2.3	-2.0	-1.4	-1.1	-0.5	-1.3	-1.5	-1.3
Illnesses of father: High blood pressure	1.4	1.8	3.8	-1.3	-1.8	-0.7	-0.7	-1.9	0.0	-1.7	-1.3	-2.0	0.1
Risk taking	1.4	2.1	5.1	1.0	-0.8	-1.1	-1.6	-1.5	-2.1	0.1	-1.2	-1.4	-2.3
Relative age of first facial hair	1.3	2.6	6.3	1.1	1.5	0.3	0.2	2.2	0.4	2.5	2.5	2.0	0.7
Number of incorrect matches in round	1.3	2.2	4.2	1.1	-1.1	-1.9	-1.9	-1.2	-2.0	0.3	-1.2	-1.4	-1.8
Number of live births	1.3	1.8	3.6	-1.6	-1.3	-1.8	-1.9	-0.9	-1.5	0.6	-0.6	-0.9	-1.4
Prospective memory result	1.3	1.6	5.9	0.7	-0.9	0.4	0.4	-1.9	-0.8	-1.3	-2.4	-1.5	-0.9
Loud music exposure frequency	1.3	1.4	3.9	-0.8	0.0	1.4	1.2	0.9	2.0	-1.1	0.8	0.9	1.6
Miserableness	1.3	2.3	4.8	1.8	2.2	-0.2	-0.5	1.8	0.1	2.1	1.9	1.8	0.2
Average weekly beer plus cider intake	1.3	1.9	4.3	1.0	2.1	1.2	1.3	1.4	0.5	1.6	1.3	1.7	1.1
Irritable Bowel Disease (IBD)	1.2	2.9	11.3	2.5	1.2	1.5	1.5	1.2	0.5	3.4	1.3	1.2	0.6
Stomach or abdominal pain in last month	1.2	1.5	3.0	-0.5	0.6	1.7	1.4	1.2	1.1	1.1	1.1	1.3	1.5
Had menopause	1.2	1.5	3.0	0.9	0.4	-1.4	-1.2	0.6	-1.4	1.6	1.7	0.3	-1.7
Depression (self-reported)	1.2	1.4	4.3	0.9	-0.4	-0.9	-1.2	-1.1	-2.1	-0.5	-0.3	-1.2	-2.0
Pulse wave Arterial Stiffness index	1.2	1.4	3.4	0.3	-1.4	-1.7	-1.8	-1.1	-1.0	-0.4	-1.1	-1.1	-1.2
Mouth/teeth dental problems: Loose teeth	1.2	1.5	4.0	-0.0	-0.7	-2.0	-1.4	-0.9	-1.7	-0.5	-1.1	-0.9	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.1	0.9	0.8	0.2	0.2	1.8	1.7	0.2	1.6	1.7	1.3
Supplements: Vitamin C	1.2	1.4	2.9	1.3	1.7	0.7	0.7	1.6	-0.3	1.6	1.4	1.4	0.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.5	-1.2	-1.4	-1.9	-1.3	-0.9	-1.1	-0.9	-0.3	-0.6	-1.7
Number of operations (self-reported)	1.2	1.7	4.4	0.2	-0.9	-1.8	-1.3	-0.9	-1.6	-1.3	-1.0	-1.0	-2.1
Townsend deprivation index at recruitment	1.1	1.6	6.1	2.5	2.1	0.3	0.1	1.3	-0.3	0.8	1.2	1.2	-0.2
Fluid intelligence score	1.1	2.3	3.9	2.0	1.8	1.3	1.5	1.6	1.4	0.7	1.3	1.3	1.9
Breastfed as a baby	1.1	1.3	4.0	2.0	1.3	-0.9	-1.0	0.6	-0.5	1.0	1.5	0.5	-1.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.2	0.1	0.7	1.2	1.8	0.6	1.9	-0.1	-0.0	0.7	2.1
Pulse wave peak to peak time	1.1	1.2	3.3	-0.2	1.2	1.7	1.8	0.8	1.0	0.3	1.0	0.8	1.2
Neck or shoulder pain in last month	1.1	1.5	3.5	-0.1	-0.6	-1.4	-1.9	-0.7	-1.8	-1.0	-0.5	-0.9	-1.9
Leg pain on walking	1.1	1.4	4.1	1.8	2.0	-0.7	-0.6	1.5	0.3	0.9	1.1	1.3	0.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.7	-0.6	-1.4	-0.8	0.0	-1.6	-1.1	-0.6	-1.7	-1.4	-0.9
Heart disease (siblings)	1.1	1.4	4.4	1.8	2.1	0.3	0.5	1.2	-0.0	1.4	1.2	1.1	-0.5
Chronotype (morning person)	1.0	2.2	3.8	0.5	1.9	1.9	1.7	1.8	1.2	1.0	0.7	1.7	1.6
Medication: Levothyroxine sodium	1.0	1.6	4.5	1.7	1.5	1.0	2.1	1.3	-0.5	0.6	1.2	1.3	-0.1
Alcohol usually taken with meals	1.0	1.6	6.5	-2.5	-2.1	-1.0	-1.2	-0.8	0.5	-0.6	-0.6	-1.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	4.2	-1.2	-0.5	-1.1	-1.0	-0.2	-2.1	0.5	-0.0	-0.1	-1.7
Smoking status: Previous	1.0	1.5	3.8	-0.8	-1.1	-0.4	0.6	-1.7	-1.1	-1.3	-2.0	-1.4	-1.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.3	-1.3	-1.8	0.7	-0.2	-1.5	-0.8	-0.5	-1.2	-1.4	-0.5
Triglycerides	0.9	1.5	4.6	-0.6	1.4	-0.1	-0.7	2.1	0.3	0.7	2.1	1.3	0.5
Blood White Count	0.9	6.5	18.9	-0.6	-3.0	-0.5	-0.2	-4.3	0.1	-1.9	-3.9	-4.1	-0.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.3	1.6	1.8	0.9	1.0	1.1	0.9	0.3	0.4	1.2	1.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.1	-1.7	-1.3	-0.5	-0.2	-0.8	-0.2	-1.8	-1.0	-1.1	-0.4
Had other major operations	0.9	1.1	3.9	0.7	0.3	-1.6	-2.0	-0.1	-0.8	-1.3	-0.1	-0.3	-1.3
Noisy workplace	0.9	1.1	3.1	-1.0	-1.1	0.9	1.0	-1.0	0.7	-1.8	-1.1	-0.8	0.7
Lung cancer (father)	0.9	1.0	2.4	1.1	1.2	1.1	0.6	0.6	1.5	-0.2	0.4	0.8	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.5	1.1	1.9	0.2	-0.4	1.4	0.4	1.5	1.7	1.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.9	-0.3	1.2	2.0	1.4	1.1	1.2	0.7	0.3	1.1	1.6
Medication: Ibuprofen	0.9	1.1	3.0	-0.2	1.0	0.9	1.0	1.0	1.7	0.0	0.4	0.9	1.7
Age at last live birth	0.9	1.4	6.5	0.8	0.5	0.8	0.4	1.2	-0.2	2.5	1.4	1.4	0.3
Alcohol drinker status: Never	0.9	1.1	2.7	-0.5	-0.6	1.3	1.4	-0.2	1.6	-0.9	-1.0	-0.0	1.5
Alcohol drinker status: Previous	0.9	1.1	3.0	-0.4	-0.8	-0.2	0.2	-1.5	-1.0	-1.0	-1.7	-1.4	-0.7
Intelligence (Savage-Jansen 2018)	0.8	2.5	6.3	1.2	1.8	0.4	0.6	2.5	1.0	0.8	2.1	2.3	1.5
Ulcerative Colitis (UC)	0.8	1.5	4.0	0.9	0.2	1.7	2.0	0.2	1.4	1.8	0.0	0.2	1.3
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.1	1.4	1.5	1.2	1.3	1.8	0.9	0.9	1.4	1.6	1.6
Bipolar Disorder (2011)	0.8	0.8	3.1	1.0	0.0	-0.6	-0.6	-0.1	-1.2	0.6	1.2	-0.2	-1.8
Neuroticism (2016)	0.8	1.2	4.3	1.2	1.0	1.0	1.0	0.9	-0.3	2.1	1.2	0.8	-0.1
Fed-up feelings	0.8	1.5	3.1	1.5	1.8	-1.3	-1.4	0.9	-0.6	1.5	1.2	0.7	-0.2
Chronic bronchitis/emphysema (father)	0.8	0.9	2.2	-0.3	1.2	1.5	1.5	-0.6	-0.5	-1.2	-1.1	-0.6	-0.1
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	3.3	1.6	0.9	1.8	0.9	0.8	0.3	0.1	0.5	0.6	0.7
Illnesses of siblings	0.8	1.2	3.7	-1.4	-1.9	1.1	0.5	-1.0	0.2	-1.0	-1.1	-1.0	0.8
Medication: Seretide 50 evohaler	0.8	0.9	3.2	-0.3	0.0	0.5	0.9	1.2	1.4	0.4	0.3	1.1	1.8
Asthma (self-reported)	0.8	1.7	4.0	-0.5	-1.5	-1.4	-0.8	-1.8	-1.2	-0.6	-1.3	-2.0	-1.1
Mother’s age at death	0.8	0.9	4.5	-0.3	0.1	-1.9	-2.1	0.1	-0.3	0.2	0.9	-0.2	-0.7
Irritability	0.8	1.4	3.3	1.1	-0.5	-0.6	-0.7	-1.8	-1.0	-1.1	-1.5	-1.7	-1.0
Basal cell carcinoma (self-reported)	0.8	1.0	2.7	-0.9	-0.5	1.3	1.6	-0.8	0.6	-0.7	-1.6	-0.5	0.4
Depressed Affect (Nagel 2018)	0.7	1.5	3.7	1.5	0.9	-1.4	-1.9	0.2	-1.6	1.5	0.7	-0.1	-1.1
Crohns Disease (2012)	0.7	1.1	6.0	2.5	-0.6	-0.3	-0.5	-0.1	-1.2	1.5	0.2	-0.1	-0.9
Schizophrenia (2014)	0.7	1.6	8.7	3.0	1.8	0.7	0.2	1.1	0.3	0.9	0.4	1.0	0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.5	0.2	-0.8	-1.5	-1.6	-0.5	-0.7	0.1	-0.1	-0.8	-1.0
Supplements: Zinc	0.7	0.7	2.3	0.8	-0.1	1.5	1.3	0.7	0.5	1.2	0.5	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.4	-0.0	-0.6	0.6	0.6	-1.9	-0.3	-1.3	-1.7	-1.3	-0.1
Hearing difficulty/problems with background noise	0.7	1.1	3.6	0.9	1.9	0.4	0.1	0.8	-0.8	1.3	1.1	1.1	-1.1
Pulse wave reflection index	0.7	0.9	3.4	-1.2	-0.5	-1.9	-1.7	-0.0	-0.5	-0.2	0.0	-0.0	-0.8
Glaucoma (self-reported)	0.7	0.8	2.3	-0.3	0.5	1.2	1.2	1.0	0.6	-0.2	1.5	1.0	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.7	1.1	0.9	0.8	1.9	1.3	0.1	0.5	1.7	1.2	0.3
High blood pressure (siblings)	0.7	1.0	4.1	1.2	2.0	-0.1	0.3	1.1	-0.2	0.6	1.3	1.2	-0.4
Health satisfaction	0.7	0.9	4.3	2.1	0.9	0.5	0.9	0.1	0.7	-0.1	-1.2	0.2	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	1.1	0.8	0.4	0.2	1.1	-0.4	1.2	1.2	1.1	-0.0
Commuting to job workplace: Walk	0.7	0.7	2.3	-0.2	-0.7	0.1	0.2	-1.0	0.9	-0.5	-1.5	-1.1	1.1
Medication: Blood pressure	0.7	1.3	3.2	0.5	1.2	1.2	1.5	0.5	1.8	-0.7	-0.0	0.8	1.6
Fractured/broken bones in last 5 years	0.7	0.9	2.2	1.3	0.9	0.1	-0.1	1.3	0.4	1.5	0.7	1.2	0.4
Bipolar Disorder or Schizophrenia	0.6	1.3	6.0	2.5	1.2	-0.4	-0.6	0.8	-0.8	1.4	0.9	0.7	-1.0
Schizophrenia (2018)	0.6	1.3	7.1	2.7	1.4	0.3	-0.1	0.6	-0.5	1.6	0.3	0.8	0.0
Worry (Nagel 2018)	0.6	1.3	3.2	1.0	-0.2	1.1	0.7	-1.5	-1.4	-0.9	-1.8	-1.2	-0.7
Coronary Artery Disease (CAD)	0.6	0.7	1.9	1.1	0.3	-0.5	-0.6	0.9	-0.0	1.4	1.2	0.9	-0.1
Smoking Status	0.6	1.3	4.8	-0.8	-1.1	0.2	0.3	-1.6	0.6	-1.3	-2.2	-1.3	0.4
Cardiovascular Disease	0.6	2.0	3.6	0.7	-1.3	-1.4	-1.3	-1.9	-1.2	-0.9	-1.1	-1.9	-1.8
Hypothyroidism (self reported)	0.6	1.5	3.0	1.6	1.0	0.9	1.7	1.5	0.2	0.3	1.7	1.4	0.4
Diabetes (mother)	0.6	0.8	3.0	0.0	-0.8	-1.4	-1.7	-0.5	-0.7	-0.5	-0.6	-0.7	-0.9
Impedance of leg (right)	0.6	2.7	7.3	0.1	1.3	-0.9	-1.2	2.1	-0.7	2.6	2.7	1.9	-0.7
Past tobacco smoking	0.6	1.1	3.1	0.5	0.8	0.2	-0.6	1.5	0.8	1.1	1.8	1.2	1.0
Hair/balding pattern: Pattern 2	0.6	0.7	1.8	-0.4	1.3	0.6	0.7	0.9	1.0	-0.1	0.9	1.1	0.9
Diabetes (self-reported)	0.6	0.9	2.4	0.9	1.3	-0.1	-0.6	1.0	0.2	1.2	1.5	1.0	-0.5
Medication: Simvastatin	0.6	0.9	3.5	1.2	0.9	-0.8	-0.6	0.8	1.9	-0.1	0.9	0.4	0.8
Happiness	0.6	0.8	3.7	1.9	0.5	0.9	0.9	-0.0	1.0	0.2	-0.4	-0.0	1.0
Asthma	0.6	1.2	2.8	-0.6	-1.1	-1.2	-0.6	-1.5	-0.9	-0.5	-1.2	-1.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	-0.2	0.8	1.1	1.4	0.7	1.1	-0.3	0.1	0.8	1.3
Medication: Cholesterol lowering	0.6	1.0	2.9	0.6	0.1	-1.5	-1.3	-0.5	-1.1	-0.9	0.3	-0.6	-1.7
Tense / ‘highly strung’	0.6	1.0	3.8	1.2	0.2	-0.1	-0.7	-0.5	-2.0	0.5	0.4	-0.2	-1.9
Exposure to tobacco smoke outside home	0.6	0.8	2.4	1.6	1.0	0.6	0.4	1.0	0.0	0.6	1.2	1.2	0.1
Suffer from ‘nerves’	0.6	0.9	6.1	2.5	0.9	0.9	0.5	-0.4	-0.8	0.6	-0.4	-0.4	-0.2
Illnesses of siblings: Diabetes	0.6	0.7	3.5	-0.5	-0.7	-1.9	-1.2	-0.5	0.8	-0.2	-0.5	-0.5	-0.1
Mood swings	0.6	1.1	3.8	1.6	1.5	-0.1	-0.4	0.5	-0.7	1.9	0.7	0.6	-0.3
Loneliness, isolation	0.6	0.8	2.9	1.7	-0.1	-0.7	-0.9	-1.0	-0.8	-0.1	-0.8	-1.1	-0.4
Diabetes diagnosed by doctor	0.6	1.1	2.6	1.0	1.4	-0.1	-0.7	1.3	0.4	1.1	1.6	1.2	-0.0
Qualifications: nursing, teaching	0.6	1.0	2.8	-0.4	-0.1	-1.4	-1.7	-0.5	-1.1	-0.8	-0.5	-0.8	-1.4
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.7	0.2	1.1	-0.8	-0.7	1.3	0.7	0.5	0.9	1.2	0.7
Medication: Atorvastatin	0.6	0.7	2.1	0.4	0.4	-0.6	-0.7	0.6	-1.5	1.2	0.8	0.4	-1.1
Age started oral contraceptive pill	0.6	0.8	2.3	0.5	1.2	-0.7	-0.2	1.5	0.4	0.4	1.4	1.0	-0.5
Commuting to job workplace: Cycle	0.6	0.8	1.8	1.3	-0.0	-0.2	-0.5	-0.7	-1.3	-0.9	-0.9	-0.5	-1.3
Pack years of smoking	0.6	0.8	1.6	1.3	0.9	0.3	0.1	1.0	1.1	0.9	0.3	1.1	1.2
Reaction Time	0.5	0.9	3.6	0.1	0.1	0.2	0.3	1.0	-0.8	1.9	1.3	1.1	-0.5
Body Mass Index (BMI) (2010)	0.5	0.7	2.3	1.0	1.5	-1.1	-0.8	0.2	-0.8	0.6	0.4	0.3	-0.7
Primary Biliary Cirrhosis	0.5	0.7	3.3	0.4	-0.5	-1.8	-1.6	-0.3	-0.3	-0.2	-0.4	-0.6	-0.7
Allergy or Eczema	0.5	1.3	4.0	-0.7	-1.1	0.1	0.3	-1.2	-2.0	-0.5	-1.7	-1.2	-1.1
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.2	0.6	1.5	0.3	-0.6	1.3	-0.1	0.8	1.8	1.2	-0.4
Neuroticism	0.5	1.1	4.1	2.0	-0.1	0.7	0.2	-1.1	-1.8	0.1	-1.1	-0.8	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	0.0	-0.6	-0.9	0.4	-0.6	-0.7	-1.3	-0.9	-0.6	-1.1
Severe depression (siblings)	0.5	0.5	1.3	-0.4	0.5	0.9	1.1	0.4	1.2	0.2	-0.3	0.5	0.9
Pack years adult smoking proportion	0.5	0.8	1.3	1.1	0.9	0.5	0.1	1.1	0.8	1.0	0.5	1.2	1.1
Neuroticism score	0.5	1.0	3.2	1.5	-0.1	-0.0	-0.4	-1.1	-1.8	0.5	-0.8	-1.0	-1.2
Worrier / anxious feelings	0.5	0.9	3.1	1.5	0.4	1.8	1.6	-0.4	-0.2	-0.4	-0.7	-0.0	0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	1.7	0.9	-0.6	-1.3	-0.9	-0.5	-1.2	-0.6	-0.6	-0.8	-1.3
Medication: Lansoprazole	0.5	0.6	1.8	1.2	0.2	-0.4	-0.7	-0.0	-1.1	0.6	-0.3	0.0	-1.3
Age at first live birth	0.5	0.9	4.4	-0.2	-0.2	1.0	0.6	0.8	-0.6	2.1	1.1	0.9	0.1
Eye problems/disorders: None of the above	0.5	0.6	1.6	-1.0	-0.3	0.7	0.7	-0.1	1.1	-1.3	-0.6	0.1	1.0
Migraine (self-reported)	0.5	0.7	1.3	0.5	1.1	1.1	0.7	1.1	0.6	-0.2	0.7	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-1.2	-0.3	0.4	0.7	-0.4	1.1	-0.5	-0.8	-0.7	1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.2	-0.1	1.1	-0.2	-0.6	0.9	0.2	1.5	1.3	0.9	0.5
Back pain experienced in last month	0.5	0.8	1.7	0.9	0.3	-1.3	-0.9	0.4	-1.2	0.7	0.8	0.2	-1.3
Osteoporosis (self-reported)	0.5	0.7	1.6	0.6	0.4	0.5	-0.7	1.3	0.1	0.8	1.3	1.2	-0.0
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	-0.5	0.6	1.3	1.3	0.3	0.6	-0.7	0.4	0.2	0.7
Myopia	0.5	0.7	1.8	1.3	0.8	-1.3	-0.5	0.7	0.5	0.7	1.1	0.3	-0.1
Pain experienced in last month	0.5	0.8	1.9	-0.4	0.2	1.4	1.0	0.3	1.4	0.6	0.4	0.3	1.4
Bipolar Disorder (2018)	0.4	0.7	2.5	0.8	0.1	-1.1	-0.8	0.5	-0.6	0.1	1.1	0.1	-1.6
Ovarian Cancer	0.4	0.5	2.3	1.5	0.5	0.1	-0.7	0.6	-0.1	0.5	1.0	0.8	-0.0
Respiratory disease	0.4	0.8	2.5	-0.1	-0.9	-1.0	-0.0	-0.9	0.7	-0.6	-1.6	-1.3	0.4
Hand grip strength (left)	0.4	1.1	3.5	-1.1	0.1	1.9	1.4	0.2	1.1	-0.3	0.2	0.4	1.6
Hearing difficulty/problems: Yes	0.4	0.5	0.9	-0.1	0.8	-0.6	-0.5	1.0	-0.3	0.9	0.9	0.9	-0.9
Vitamin and mineral supplements	0.4	0.5	1.5	-0.2	-0.2	-0.5	-0.6	-1.2	-0.6	-1.0	-1.0	-0.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.8	1.7	0.7	0.0	-0.0	0.4	0.2	0.9	0.4	0.6	0.8
Taking other prescription medications	0.4	0.6	2.3	0.7	0.7	0.6	1.5	0.7	0.7	0.2	0.5	0.8	0.7
Qualifications: CSEs or equivalent	0.4	0.5	1.7	-0.8	-0.5	-0.5	-0.9	0.1	1.0	-1.3	0.1	0.2	0.3
Impedance of leg (left)	0.4	1.9	5.5	0.6	0.9	-1.0	-1.1	1.4	-0.9	2.4	2.1	1.3	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.2	1.1	-0.1	-0.3	-0.2	-0.9	-1.8	0.1	-0.5	-1.1	-1.2
Qualifications: None of the above	0.4	0.9	3.0	0.6	-0.2	-0.9	-0.7	-0.9	-1.5	0.5	-0.6	-1.0	-1.7
Allergy	0.4	0.9	3.3	0.4	0.6	-0.4	-1.0	1.0	0.9	0.9	1.8	1.1	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.4	0.4	1.3	0.5	0.3	1.3	-0.0	0.6	1.3	1.5	0.5
Illnesses of mother	0.4	0.5	0.9	-0.5	-0.9	1.0	0.1	-0.7	-0.7	-0.0	-0.6	-0.9	-0.7
Medication: Amlodipine	0.4	0.5	1.4	0.6	1.0	0.6	1.2	0.5	0.8	0.5	0.1	0.6	0.8
Comparative body size at age 10	0.4	1.1	2.0	-1.0	-1.0	0.9	1.2	-0.4	1.4	-1.4	-1.0	-0.5	1.0
Angina (self-reported)	0.4	0.5	1.4	0.8	-0.4	-1.2	-0.8	-0.9	-0.5	-0.7	-0.3	-0.5	-0.8
Medication: Allopurinol	0.4	0.6	1.8	-1.0	-0.3	1.2	1.4	0.3	0.6	0.5	-0.0	0.5	0.9
Mean time to correctly identify matches	0.4	0.8	3.4	0.3	0.3	-0.3	0.2	0.9	-0.9	1.8	1.2	1.0	-0.7
Alcohol intake frequency.	0.4	1.0	3.7	1.9	0.3	0.2	0.7	-1.0	0.1	-1.6	-1.2	-0.8	0.4
Had major operations	0.4	0.5	1.7	-0.7	-0.4	1.0	1.3	-0.4	0.8	-0.6	-0.1	-0.2	0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	-0.5	-0.4	1.0	0.4	0.4	-0.3	0.4	1.2	0.6	-0.6
Illnesses of father: Heart disease	0.4	0.5	2.4	0.1	-0.5	-1.1	-1.6	-0.3	-0.4	0.5	0.2	-0.4	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	2.6	0.9	-0.4	-0.3	-0.1	-0.2	-1.6	0.2	-0.2	-0.1	-0.7
Wears glasses or contact lenses	0.4	0.5	0.9	0.9	0.8	-0.3	0.3	0.7	0.9	0.7	0.4	1.0	0.7
Commuting to job workplace: Public transport	0.4	0.5	2.2	0.5	0.6	-0.0	0.5	0.5	0.4	1.5	-0.2	0.4	1.0
High cholesterol (Self-reported)	0.4	0.7	2.8	1.7	0.6	-0.5	-0.6	0.7	-0.4	0.7	0.9	0.7	-0.8
Medication: Lisinopril	0.4	0.5	1.7	-0.1	-0.5	0.7	1.3	-0.6	0.7	-0.1	-1.1	-0.2	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	1.0	0.8	-0.4	-0.2	0.1	-1.0	0.6	0.5	0.1	-1.3
Depression (Nagel 2018)	0.3	0.5	1.5	0.6	0.5	-0.6	-1.0	-0.5	-1.2	-0.5	-0.3	-0.5	-0.6
Breast Cancer	0.3	0.6	1.5	-0.7	0.5	1.2	0.8	0.5	0.7	1.2	0.3	0.5	1.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.5	1.2	-0.1	0.2	0.2	-0.3	-0.1	-1.1	-0.5	-0.3	0.4
Blood Eosinophil Count	0.3	2.6	7.7	1.6	-1.8	0.1	0.3	-2.8	-0.5	0.7	-2.3	-2.5	0.3
Waist Hip Ratio (WHR)	0.3	1.2	2.8	-0.2	0.9	-1.1	-0.7	1.4	0.3	1.4	1.7	1.4	0.4
Angina	0.3	0.5	1.6	0.5	-0.3	-1.3	-0.9	-0.6	-0.6	-0.5	-0.1	-0.3	-0.9
Diabetes (father)	0.3	0.4	1.1	-0.8	-0.6	-0.8	-0.6	-0.7	0.0	-0.3	-0.5	-1.0	-0.4
Average weekly fortified wine intake	0.3	0.4	1.0	0.9	0.1	-0.9	-1.0	0.0	0.2	0.5	0.9	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.3	0.9	-0.0	-0.7	-1.1	-0.4	-1.5	-0.2	0.2	-0.7	-1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.9	0.9	-0.0	-0.4	-0.5	0.0	1.0	-0.6	-0.5	-0.1	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	-0.5	-0.7	0.5	0.6	-0.9	-0.8	-0.7	-1.3	-0.9	-0.2
Multivitamins +/- minerals	0.3	0.4	0.9	-0.6	-0.3	0.6	0.9	0.6	1.0	0.2	0.6	0.5	0.6
Medication: Atenolol	0.3	0.3	0.7	0.1	-0.8	-0.2	0.5	-0.8	0.9	-0.4	-0.4	-0.8	0.3
High blood pressure (mother)	0.3	0.5	2.0	0.3	-0.1	-1.4	-0.9	-0.7	0.4	-0.8	0.0	-0.6	0.1
Nervous feelings	0.3	0.6	2.0	1.1	-0.1	0.9	0.6	-1.0	-0.1	0.1	-1.4	-0.8	0.1
Mouth/teeth dental problems	0.3	0.4	1.2	-0.9	-0.7	1.1	0.2	-0.3	0.2	-0.6	-0.8	-0.4	0.2
Heart attack	0.3	0.4	1.9	0.8	0.5	-0.6	-0.3	-0.2	-1.0	0.3	0.3	-0.1	-1.4
Pain all over the body in last month	0.3	0.3	1.1	-0.4	0.3	0.0	-0.5	0.2	1.0	-0.7	-0.2	0.3	1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.8	-0.1	-1.3	0.3	0.7	-0.9	0.0	-0.2	-0.5	-0.8	0.7
Impedance of arm (right)	0.3	1.3	2.9	-1.1	0.7	1.1	0.7	1.2	-0.2	1.6	1.7	1.4	0.2
Father’s age at death	0.3	0.4	1.3	-0.2	-0.4	-0.6	-0.8	0.6	-0.6	1.1	0.2	0.3	-0.5
Falls in the last year	0.3	0.5	2.1	1.2	-0.2	-0.5	-0.5	0.6	-0.4	1.4	0.3	0.1	-0.2
Hair/balding pattern: Pattern 4	0.3	0.8	2.0	-0.5	-0.7	-1.4	-0.8	-0.7	-1.1	-1.2	-0.4	-0.9	-0.9
Peak expiratory flow (PEF)	0.3	0.8	2.9	-1.7	-0.3	-1.1	-1.2	-0.3	0.8	-0.9	-0.4	-0.6	0.1
Headache pain in last month	0.3	0.5	1.4	-0.3	-0.1	-1.2	-0.7	-0.5	-0.3	-1.0	-0.8	-0.8	-0.7
Birth weight	0.3	0.6	1.8	1.3	1.2	-0.4	0.1	0.7	-0.6	0.1	0.8	0.8	-0.8
Overall health rating	0.3	0.6	2.0	1.4	0.3	0.4	1.3	-0.1	0.8	-0.5	-0.5	-0.0	0.8
Long-standing illness, disability or infirmity	0.3	0.4	2.0	1.4	0.4	-0.4	0.7	0.2	0.6	-1.0	-0.4	0.4	-0.0
Medication for cholesterol	0.3	0.5	1.8	-0.1	0.4	0.7	0.0	0.7	-0.8	1.4	0.8	0.7	-0.3
Medication: Aspirin	0.3	0.4	1.4	-0.2	-0.6	-0.0	-0.6	-1.2	-0.2	-0.1	-0.4	-1.0	-0.8
Medication: Gliclazide	0.3	0.4	1.6	-0.5	0.1	-0.2	-0.6	-0.0	1.1	-1.3	-0.0	0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	3.7	-1.9	0.6	-0.1	-0.7	0.5	0.1	-0.0	0.5	0.6	0.2
Number of self-reported non-cancer illnesses	0.3	0.5	3.0	1.7	0.5	-0.9	0.2	0.2	-0.2	-0.5	0.4	0.1	-0.5
Ever depressed for a whole week	0.3	0.4	1.4	-0.4	-0.2	-0.2	-1.2	-0.1	-1.1	0.5	0.3	-0.4	-0.9
Unable to work because of sickness or disability	0.3	0.4	2.1	1.4	0.3	0.7	0.4	-0.3	-0.8	-0.1	-0.2	0.0	-0.8
Cholesterol lowering medication	0.3	0.4	1.6	1.1	0.0	0.2	0.2	-0.3	1.3	-0.3	-0.5	-0.5	0.7
Neuroticism (Nagel 2018)	0.2	0.4	1.9	1.1	0.4	-0.4	-0.6	-0.2	-1.4	0.1	-0.1	-0.5	-0.6
Rheumatoid Arthritis	0.2	0.2	0.8	0.6	0.3	-0.9	-0.4	0.3	-0.5	0.4	0.2	0.4	-0.3
Ulcerative Colitis	0.2	0.3	0.9	0.2	-0.8	-0.0	0.2	-0.6	0.9	0.3	-0.9	-0.7	0.3
Blood Red Count	0.2	1.7	4.2	0.6	1.4	-1.5	-0.2	1.6	-0.1	2.0	2.0	1.1	-0.1
Number of treatments/medications taken	0.2	0.4	1.7	-0.0	-0.7	0.6	1.1	-0.4	0.5	-1.3	-0.5	-0.3	0.0
Average weekly spirits intake	0.2	0.3	0.8	0.7	0.3	-0.0	-0.0	-0.6	-0.2	-0.6	-0.9	-0.5	-0.2
Sensitivity / hurt feelings	0.2	0.3	0.8	-0.4	-0.8	-0.3	-0.3	-0.4	-0.9	0.6	-0.0	-0.3	-0.4
Systolic blood pressure, automated reading	0.2	0.5	1.6	-0.0	-0.5	-0.1	0.8	-1.0	-0.6	-0.0	-1.3	-0.8	-0.9
Hand grip strength (right)	0.2	0.6	1.9	0.1	0.5	1.4	1.1	0.5	0.5	0.0	0.5	0.5	1.3
Current tobacco smoking	0.2	0.4	1.7	0.7	0.1	-0.3	-0.6	0.3	0.5	1.3	0.2	0.3	0.6
Maternal smoking around birth	0.2	0.3	1.5	-1.2	-0.9	0.8	0.5	0.1	-0.1	0.3	0.2	0.3	0.2
Age when periods started (menarche)	0.2	0.4	1.4	0.0	-0.3	-0.9	-0.0	-0.5	-0.8	-0.1	0.7	-0.7	-1.2
Serious illness, injury or assault to yourself	0.2	0.2	0.6	-0.2	-0.4	-0.1	0.6	0.7	0.0	0.8	0.2	0.7	0.3
High blood pressure	0.2	0.5	1.9	1.4	0.1	-0.8	-0.2	-0.8	-0.0	-0.7	-0.6	-0.7	-0.4
Time employed in main current job	0.2	0.2	0.6	0.2	-0.8	0.7	0.4	-0.2	-0.5	0.4	-0.1	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.6	-1.6	0.4	-0.7	-1.0	0.4	0.7	-0.0	-0.1	0.3	0.6
Impedance of arm (left)	0.2	0.9	1.9	-1.3	0.4	1.0	0.8	0.9	-0.2	1.2	1.4	1.0	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	-0.7	-0.5	-0.1	-0.1	-0.6	-1.0	-1.1	-0.5	-0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	-0.7	-0.3	-0.4	-0.3	-0.8	-0.4	-0.5	-0.2	-0.6	-0.3
Medication: Paracetamol	0.2	0.3	1.0	0.2	-0.5	-0.1	-0.3	-0.2	-0.8	-0.7	-0.2	-0.3	-1.0
Leg fat percentage (right)	0.2	0.6	1.8	1.3	0.5	-0.3	-0.1	0.8	-0.3	0.9	1.3	0.8	-0.5
Worry too long after embarrassment	0.2	0.3	1.1	-0.8	-1.1	-0.2	-0.1	-0.3	-0.7	0.6	-0.6	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.2	-0.2	0.8	0.7	0.6	0.5	0.4	0.3	0.8	0.6
Shortness of breath walking on level ground	0.2	0.3	0.7	0.4	-0.0	0.7	0.6	0.2	0.8	0.2	-0.6	0.4	0.8
Qualifications: College or University degree	0.2	0.6	1.4	-0.5	-0.0	-0.3	-0.5	-1.1	-1.1	-0.7	-1.0	-1.2	-0.6
Medication: Blood pressure	0.2	0.3	1.4	0.7	-0.3	-1.2	-0.7	-0.2	-0.5	0.3	0.2	-0.1	-0.5
Pulse rate, automated reading	0.2	0.7	1.6	1.2	1.0	-0.4	-1.0	0.0	-1.3	0.2	-0.3	0.3	-0.9
Medication: Aspirin	0.2	0.2	0.8	-0.2	-0.2	-0.1	-0.5	-0.9	-0.1	-0.5	-0.3	-0.7	-0.6
Hypertension (Self-reported)	0.2	0.4	1.5	1.2	-0.2	-0.7	-0.1	-0.8	0.0	-0.8	-0.7	-0.7	-0.3
Leg fat-free mass (right)	0.2	0.9	1.7	0.5	-0.5	1.1	1.3	-1.0	0.8	-1.2	-0.8	-0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.6	-0.3	-0.4	-0.7	0.3	-0.2	-0.2	0.9	0.2	-0.2
Breast cancer (self-reported)	0.2	0.2	0.5	0.2	-0.2	-0.1	-0.5	-0.5	-0.4	-0.7	-0.1	-0.5	-0.7
Leg predicted mass (right)	0.2	0.8	1.5	0.5	-0.6	1.0	1.2	-1.0	0.7	-1.2	-0.8	-0.9	0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.6	-0.9	-0.2	-0.6	-0.2	-0.7	-0.4	-0.2	-0.3	-0.3
Guilty feelings	0.2	0.2	0.6	-0.1	-0.2	-0.4	-0.2	-0.8	-0.5	-0.6	-0.6	-0.5	-0.5
Medication: Paracetamol	0.2	0.3	1.0	0.7	-0.1	-0.2	-0.5	0.1	-0.8	-0.2	0.5	0.0	-1.0
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.3	-1.1	-0.1	0.9	0.2	0.9	-0.4	0.9	0.6	0.6	0.2
Impedance of whole body	0.2	1.2	4.4	-0.3	0.8	0.2	-0.1	1.3	-0.4	2.1	1.9	1.3	-0.3
Major Depression (MDD)	0.1	0.2	0.9	0.3	0.2	0.4	0.6	-0.1	-0.1	-0.9	-0.3	0.1	0.2
Age at First Birth	0.1	0.2	1.0	1.0	-0.2	-0.2	0.3	-0.2	0.1	-0.5	-0.5	0.3	0.2
Lupus	0.1	0.2	0.6	-0.8	-0.1	-0.1	0.3	0.3	0.8	0.1	0.5	0.1	0.4
Heel T-Score	0.1	0.8	1.9	-0.1	-0.5	-0.7	-1.1	-0.8	-1.3	1.4	-0.1	-1.0	-1.1
BMI	0.1	0.7	3.0	-0.4	-1.7	-0.8	-0.7	-1.0	-0.2	-0.2	-0.3	-1.1	-0.5
Systolic Blood Pressure	0.1	0.7	1.6	-0.8	-0.7	-0.8	-0.1	-1.3	-0.8	-0.3	-0.9	-1.0	-1.1
Lung FEV1/FVC ratio	0.1	0.6	2.2	-1.5	0.3	-1.1	-1.4	-0.0	-0.2	0.1	0.3	0.2	-0.4
Lung FVC	0.1	0.4	2.2	-1.5	-0.8	0.0	-0.4	0.1	-0.8	0.2	0.1	-0.2	-0.6
Tanning	0.1	1.5	4.1	-1.3	-1.5	-1.8	-2.0	-0.5	-0.7	0.0	-0.3	-1.0	-1.2
Medication: Co-codamol	0.1	0.1	0.7	0.5	0.3	-0.3	-0.1	-0.0	0.4	0.9	0.1	-0.0	-0.2
Medication: Metformin	0.1	0.1	0.4	-0.4	0.3	0.1	-0.4	0.0	0.4	-0.6	0.1	-0.1	-0.2
Leg fat-free mass (left)	0.1	0.6	1.3	0.5	-0.2	1.1	1.1	-0.6	0.7	-0.9	-0.4	-0.5	0.9
Trunk fat percentage	0.1	0.2	0.8	0.4	-0.3	0.3	0.9	-0.3	-0.3	0.8	0.5	-0.1	-0.2
Body mass index (BMI)	0.1	0.2	0.5	0.6	-0.6	-0.2	0.3	-0.7	-0.2	-0.6	-0.4	-0.6	-0.3
Leg predicted mass (left)	0.1	0.6	1.4	0.5	-0.3	1.1	1.2	-0.6	0.7	-0.9	-0.4	-0.5	0.9
Waist circumference	0.1	0.4	1.3	1.1	0.6	0.0	0.7	0.4	0.6	0.6	0.7	0.6	0.3
Forced vital capacity (FVC)	0.1	0.4	2.4	-1.6	-0.2	0.1	-0.6	-0.2	0.4	0.2	-0.4	-0.3	0.4
Financial difficulties in last 2 years	0.1	0.1	0.5	0.1	-0.4	0.0	-0.2	0.2	0.7	0.0	0.2	0.6	0.5
Trunk fat-free mass	0.1	0.3	1.1	1.0	0.0	-0.1	0.4	-0.5	0.5	-0.9	-0.6	-0.4	0.7
Hip circumference	0.1	0.5	1.6	1.3	0.7	0.7	1.1	0.2	0.6	0.4	0.4	0.5	0.4
Alcohol intake versus 10 years previously	0.1	0.2	1.0	1.0	0.7	-0.2	-0.3	-0.0	-0.2	0.3	0.0	0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.4	1.2	0.2	-0.3	-0.6	0.0	0.3	-0.0	-0.1	-0.2	0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.6	-0.0	-0.8	-0.1	-0.1	-0.1	-0.5	0.2	-0.1	-0.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	4.0	-2.0	0.1	0.0	-0.8	0.2	0.4	0.2	0.2	0.2	0.3
Pulse rate	0.1	0.2	0.6	0.8	-0.0	0.7	-0.3	0.2	0.5	-0.6	-0.4	0.1	0.6
Trunk predicted mass	0.1	0.4	1.3	1.1	0.0	-0.1	0.3	-0.5	0.5	-1.0	-0.6	-0.5	0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.5	-0.0	-0.0	-0.3	-0.7	0.2	-0.4	-0.7	0.2	-0.2	-0.2
Gout (self-reported)	0.1	0.2	0.9	-0.5	-0.0	0.1	0.6	0.2	-0.4	0.9	0.0	0.2	0.0
Forced vital capacity (FVC), Best measure	0.1	0.4	1.5	-1.2	0.4	-0.4	-0.8	0.4	0.7	0.3	-0.2	0.2	0.7
Body fat percentage	0.1	0.2	0.4	0.6	-0.2	0.1	0.6	-0.2	-0.6	0.6	0.6	0.1	-0.6
Arm fat-free mass (right)	0.1	0.3	1.7	1.3	-0.1	0.0	0.4	-0.5	0.4	-0.5	-0.4	-0.5	0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.2	0.3	-0.3	-0.4	0.5	0.5	0.6	0.4	0.4	0.6
Leg fat mass (right)	0.1	0.2	1.2	1.1	-0.2	-0.3	-0.0	-0.1	-0.5	0.1	0.4	-0.1	-0.6
Arm predicted mass (right)	0.1	0.3	1.6	1.2	-0.0	-0.1	0.3	-0.5	0.2	-0.4	-0.5	-0.6	0.1
Chest pain or discomfort	0.1	0.2	0.6	-0.6	0.2	-0.3	-0.4	0.3	-0.3	0.6	0.3	0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.8	-0.7	0.1	0.1	-0.1	0.7	-0.7	-0.3	-0.1	0.4
Whole body fat-free mass	0.1	0.4	1.1	1.0	-0.2	0.3	0.7	-0.7	0.5	-0.9	-0.6	-0.6	0.6
Average weekly red wine intake	0.1	0.2	1.0	-0.5	-0.5	-0.5	-0.2	-0.0	-0.3	-0.0	-0.0	0.1	-1.0
Ever had bowel cancer screening	0.1	0.1	0.7	-0.4	-0.8	0.0	0.1	-0.3	0.1	-0.1	-0.2	-0.6	-0.2
Mineral and other dietary supplements	0.1	0.2	0.7	0.3	0.6	0.5	0.2	-0.3	0.3	-0.3	-0.8	0.0	0.5
Smoking status: Current	0.1	0.2	0.5	0.6	-0.1	-0.4	-0.5	0.0	0.6	0.7	-0.0	0.0	0.6
Whole body water mass	0.1	0.4	0.8	0.8	-0.2	0.2	0.6	-0.6	0.5	-0.9	-0.6	-0.6	0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.3	-0.4	-0.6	-0.2	0.4	-0.3	0.2	0.5	-0.1	-0.6
Ever smoked	0.1	0.2	0.7	-0.4	0.1	-0.2	0.5	-0.2	-0.3	-0.0	-0.9	-0.2	-0.4
Basal metabolic rate	0.1	0.3	0.7	0.8	-0.2	0.4	0.7	-0.6	0.5	-0.8	-0.5	-0.5	0.6
Leg fat percentage (left)	0.1	0.5	1.9	1.4	0.3	-0.3	-0.0	0.4	-0.4	0.8	1.0	0.5	-0.7
Arm fat-free mass (left)	0.1	0.3	2.3	1.5	0.3	0.1	0.4	-0.0	0.4	-0.1	0.0	-0.0	0.5
Diastolic blood pressure, automated reading	0.1	0.2	1.5	-0.2	0.0	-0.3	0.4	-0.6	0.4	-0.1	-1.2	-0.5	0.1
Leg fat mass (left)	0.1	0.2	1.1	1.1	-0.3	-0.3	0.1	-0.3	-0.6	0.2	0.3	-0.2	-0.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.8	2.3	0.9	1.5	0.5	0.8	0.9	1.0	0.2	0.3	1.1	1.0
Hair Pigment	0.0	0.2	1.3	-0.1	0.3	0.1	0.4	0.1	0.4	-1.1	0.4	0.0	0.1
Sitting height	0.0	0.2	1.5	-0.2	-0.1	0.6	0.0	-0.3	-0.1	1.2	0.3	-0.3	0.1
Trunk fat mass	0.0	0.2	0.7	0.6	-0.4	0.3	0.9	-0.4	-0.1	0.4	0.2	-0.2	-0.0
Weight	0.0	0.1	0.3	0.6	-0.3	0.1	0.5	-0.5	0.1	-0.3	-0.1	-0.4	0.0
Arm fat percentage (right)	0.0	0.2	0.3	0.3	-0.5	0.1	0.6	-0.5	-0.5	-0.1	0.1	-0.2	-0.5
Arm fat mass (right)	0.0	0.1	0.6	0.4	-0.3	0.1	0.8	-0.5	-0.2	-0.3	-0.0	-0.2	-0.1
Standing height	0.0	0.1	0.4	-0.2	0.2	0.4	0.3	0.1	0.1	0.4	0.6	0.2	0.3
Wheeze or whistling in the chest in last year	0.0	0.1	0.3	0.5	0.4	0.3	0.3	0.0	0.2	0.1	-0.3	-0.0	0.2
Whole body fat mass	0.0	0.2	0.4	0.7	-0.4	-0.0	0.6	-0.4	-0.4	0.3	0.1	-0.2	-0.3
Comparative height size at age 10	0.0	0.3	1.7	0.3	0.3	0.2	0.0	-0.4	0.4	1.3	0.4	-0.3	0.3
Arm fat percentage (left)	0.0	0.2	0.8	0.3	-0.5	0.3	0.9	-0.6	-0.3	-0.1	0.0	-0.3	-0.2
Arm fat mass (left)	0.0	0.2	0.6	0.4	-0.4	0.2	0.8	-0.5	-0.3	-0.2	-0.1	-0.3	-0.2
Arm predicted mass (left)	0.0	0.2	1.5	1.2	-0.0	-0.2	0.2	-0.5	0.1	-0.5	-0.4	-0.4	0.2

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