Hub : Genes

SYTL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.5880	0.1050	3.1e-04	0.047	NA	0.021	NA	0.097	2.4e-02	NA	9.2e-02	NA	1.8e-03
2	GTEx	Brain Cerebellum	0.3320	0.1170	1.5e-03	0.063	NA	0.128	NA	0.158	6.3e-03	NA	1.3e-04	NA	2.1e-05
3	GTEx	Esophagus Mucosa	0.0980	0.0530	8.9e-03	0.032	NA	0.043	NA	0.044	3.0e-03	NA	7.5e-04	NA	6.1e-04
4	YFS	Blood	0.0713	0.0225	2.3e-07	0.035	0.03	0.030	0.029	0.031	1.7e-11	3.4e-10	3.0e-10	5.8e-10	1.4e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.8	0.9	0.1	0.0	-0.3
Bipolar Disorder or Schizophrenia	1.2	3.0	4.3	2.0	2.1	0.0	1.9
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	0.9	-0.3	-0.7	-0.3
Depression (Nagel 2018)	0.6	0.9	1.4	1.2	-0.2	-0.9	-1.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.2	0.0	-1.5	-1.4	-1.1
Neuroticism (Nagel 2018)	0.2	0.5	2.0	1.4	0.3	0.0	0.2
Schizophrenia (2018)	2.0	4.1	7.3	1.7	2.5	0.0	2.7
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	-0.6	1.1	0.0	1.0
Worry (Nagel 2018)	0.7	1.5	4.8	2.2	1.1	0.2	0.4
Alzheimer’s Disease (in mother)	1.1	1.2	1.9	0.2	-1.3	-1.1	-1.4
Alzheimer’s Disease (in father)	0.5	0.5	0.9	0.2	-0.5	-0.9	-1.0
Alzheimer’s Disease (including proxy)	0.9	1.3	2.1	0.7	-1.0	-1.3	-1.4
Crohns Disease (2017)	0.1	0.2	0.6	0.1	0.7	0.4	0.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.2
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.3	-0.3	0.2	-0.1
Major Depression (MDD)	0.4	0.5	1.9	-0.5	0.0	0.0	1.4
Reaction Time	0.5	1.0	2.9	1.7	0.7	0.5	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	1.1	-0.4	-0.4	0.0
Breast Cancer	0.7	1.7	5.5	-2.3	-0.2	-0.7	-0.9
Ovarian Cancer	0.0	0.0	0.1	0.1	0.3	-0.1	-0.2
Prostate Cancer	0.5	0.7	2.0	-0.3	1.4	0.4	0.8
Age at First Birth	0.8	1.2	3.5	-1.9	0.0	1.0	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	-1.0	-0.1	0.9	0.8
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.5	1.0	-0.5	1.0	0.8	0.6
Mean Putamen Volume	3.2	3.6	4.9	-2.0	-2.2	-1.3	-1.9
Fasting Glucose	0.6	0.7	1.8	-0.2	-0.7	-0.6	-1.3
HbA1C	1.2	1.4	4.9	-2.2	-0.7	0.2	-0.0
HDL Cholesterol	3.1	5.2	7.4	1.1	2.3	2.7	2.7
LDL Cholesterol	2.5	3.9	5.8	-1.2	-2.4	-2.2	-1.8
Lupus	0.5	0.7	1.3	0.8	0.1	1.1	1.0
Neuroticism (2016)	0.8	1.1	1.7	-1.0	-1.3	-1.0	-0.8
Primary Biliary Cirrhosis	1.1	1.6	3.0	0.0	1.2	1.7	1.4
Rheumatoid Arthritis	0.2	0.2	0.5	-0.4	0.3	0.7	0.3
Schizophrenia (2014)	2.3	5.0	8.0	2.1	2.8	0.0	2.8
Triglycerides	0.0	0.1	0.1	-0.4	-0.3	-0.3	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.2	0.4	-0.6	-0.6	0.0	-0.2
Blood Eosinophil Count	1.9	14.4	24.1	0.6	-3.2	-4.9	-4.8
Blood Platelet Count	2.6	30.3	41.0	-0.8	-6.4	-6.2	-6.4
Blood Red Count	0.2	2.2	3.5	-1.0	-1.6	-1.9	-1.2
Blood White Count	0.0	0.3	0.9	1.0	-0.3	0.2	-0.1
Heel T-Score	1.2	9.9	22.4	-3.8	-4.7	-1.4	-0.8
BMI	0.2	1.0	1.6	-0.5	0.9	1.1	1.3
Height	1.0	19.6	24.8	-2.8	-4.8	-5.0	-4.8
Waist Hip Ratio (WHR)	0.2	0.9	2.1	-0.7	-0.3	1.0	1.4
Systolic Blood Pressure	2.5	12.6	21.2	1.2	-2.9	-4.6	-4.4
Smoking Status	0.3	0.7	1.1	0.8	0.6	1.0	0.9
Allergy or Eczema	0.8	2.2	3.8	-1.0	-1.9	-1.6	-1.2
Cardiovascular Disease	4.9	16.1	23.2	-0.3	-4.6	-4.8	-4.5
Hypothyroidism (self reported)	0.0	0.1	0.3	-0.1	0.1	-0.5	-0.3
Respiratory disease	0.0	0.1	0.1	-0.0	-0.3	-0.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.1	0.4	-0.3	0.2
Lung FEV1/FVC ratio	0.2	0.9	1.6	0.2	1.0	1.3	1.1
Lung FVC	0.3	1.6	3.0	-0.2	1.4	1.7	1.1
Neuroticism	0.0	0.0	0.2	0.4	0.0	0.1	-0.0
Chronotype (morning person)	1.4	3.3	4.4	-1.0	2.0	2.0	2.1
Hair Pigment	0.0	0.6	1.9	-0.6	-1.4	-0.6	-0.0
Tanning	0.2	2.2	5.4	1.2	2.3	1.1	0.8
Hand grip strength (left)	0.2	0.5	0.7	-0.6	-0.8	-0.8	-0.4
Number of treatments/medications taken	1.2	2.1	6.6	-0.3	-2.6	-0.9	-0.9
Average weekly spirits intake	0.4	0.5	1.1	1.0	0.7	0.2	0.7
Sensitivity / hurt feelings	1.4	2.4	4.4	1.0	-0.3	-2.1	-2.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	1.1	-0.3	-0.8	-1.1
Hearing difficulty/problems: Yes	1.1	1.7	3.3	-1.2	0.6	1.8	1.3
Relative age of first facial hair	0.5	1.1	1.9	1.0	-1.4	-0.9	-0.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.5	0.9	0.5	1.2	1.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	-0.6	-0.2	0.0	0.1
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.8	-0.9	0.0	0.2
Systolic blood pressure, automated reading	2.8	8.1	14.3	0.8	-2.0	-3.8	-3.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	1.0	1.4	0.9	0.9
Angina	0.4	0.5	1.0	0.8	0.4	-1.0	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.4	-0.6	0.2	0.5
Vitamin and mineral supplements	0.5	0.7	1.2	-0.6	-1.1	-0.8	-0.7
Supplements: Zinc	0.1	0.2	0.3	-0.5	0.0	-0.4	-0.4
Medication: Co-codamol	2.2	2.6	5.4	1.1	2.3	1.4	1.3
Medication: Metformin	0.6	0.8	2.0	1.4	1.1	-0.3	-0.0
Diabetes (father)	0.3	0.3	1.2	1.1	0.1	-0.3	-0.2
Diabetes (mother)	3.6	4.6	8.8	-0.2	-1.3	-2.8	-3.0
Severe depression (siblings)	0.3	0.3	1.0	1.0	0.1	0.5	-0.1
Pack years adult smoking proportion	0.3	0.4	1.1	-0.0	-0.2	-1.0	-0.7
Impedance of leg (right)	0.6	2.7	7.3	-0.8	-2.7	-1.2	-1.3
Leg fat-free mass (left)	0.1	0.5	1.3	-1.1	0.9	-0.3	0.1
Trunk fat percentage	0.1	0.6	1.1	-1.1	-0.9	-0.5	-0.3
Hand grip strength (right)	0.1	0.4	0.6	-0.6	-0.8	-0.7	-0.3
Townsend deprivation index at recruitment	1.3	1.9	3.8	1.9	2.0	0.5	0.2
Current tobacco smoking	1.1	1.8	2.2	1.4	1.3	1.5	1.3
Average weekly fortified wine intake	0.3	0.3	1.1	-0.0	1.0	-0.0	0.4
Maternal smoking around birth	0.3	0.5	1.1	1.1	0.6	-0.2	-0.5
Fed-up feelings	0.6	1.1	1.7	1.3	-0.5	-1.1	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	1.4	-0.5	-0.2	-1.1
Relative age voice broke	0.2	0.3	0.9	0.9	-0.2	0.4	0.2
Taking other prescription medications	0.4	0.5	0.7	0.8	-0.9	-0.6	-0.7
Age when periods started (menarche)	0.1	0.2	0.4	0.5	0.1	0.3	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.6	-0.2	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.5	-0.5	-1.9	-1.2	-1.4
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.1	1.4	0.1	-1.1	-1.4
Qualifications: CSEs or equivalent	0.1	0.2	0.6	-0.0	-0.0	0.8	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.4	0.2	0.6	0.5
High blood pressure	3.5	9.9	16.8	1.4	-2.9	-4.1	-3.6
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.0	-0.3	-1.4	-1.3	-1.1
Multivitamins +/- minerals	0.7	0.9	1.7	0.7	1.3	0.8	0.8
Stomach or abdominal pain in last month	0.9	1.1	3.0	-0.6	0.4	1.7	0.9
Supplements: Glucosamine	0.3	0.4	0.8	-0.5	-0.5	0.7	0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	-1.0	-0.3	1.4	0.5
Medication: Atenolol	1.6	2.0	3.4	0.5	-1.0	-1.8	-1.9
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.3	-0.2	0.4	0.3
Sitting height	0.4	2.6	3.2	-1.7	-1.4	-1.8	-1.6
Chronic bronchitis/emphysema (father)	1.3	1.6	3.0	0.4	1.2	1.3	1.7
High blood pressure (mother)	4.8	6.7	12.5	-0.7	-2.0	-3.5	-3.1
Body mass index (BMI)	0.2	1.0	2.3	0.1	1.5	0.6	1.1
Impedance of leg (left)	0.8	3.7	8.4	-0.2	-2.9	-1.7	-1.9
Leg predicted mass (left)	0.1	0.5	1.1	-1.0	0.9	-0.2	0.2
Trunk fat mass	0.1	0.5	1.5	-1.2	-0.4	-0.4	-0.1
Waist circumference	0.1	0.2	0.8	-0.9	0.1	-0.0	0.3
Number of incorrect matches in round	1.6	2.7	4.9	-0.3	1.3	2.0	2.2
Past tobacco smoking	0.7	1.3	3.7	-1.9	-1.1	-0.4	-0.6
Alcohol usually taken with meals	0.4	0.6	1.8	-1.4	-0.7	-0.2	-0.0
Nervous feelings	0.6	1.2	1.6	1.2	-0.2	-1.2	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	9.6	3.1	0.4	-0.3	-0.8
Hearing difficulty/problems with background noise	1.2	2.0	2.9	-0.0	1.5	1.7	1.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.7	-0.4	0.8	0.3
Had menopause	0.1	0.1	0.2	-0.5	0.3	-0.2	0.2
Had other major operations	0.2	0.2	0.6	-0.8	-0.4	-0.1	0.2
Forced vital capacity (FVC)	0.0	0.1	0.4	-0.6	0.1	-0.1	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.3	-0.8	-2.1	-0.8	-1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	1.5	-0.1	-1.2	-0.7
Qualifications: None of the above	0.2	0.5	1.7	-0.4	1.3	0.2	0.3
Financial difficulties in last 2 years	0.5	0.6	1.9	1.4	0.6	-0.2	-0.5
Mouth/teeth dental problems	0.7	1.1	2.6	-1.6	-1.0	-0.5	-0.8
Heart attack	1.2	1.5	2.8	1.7	0.9	-1.0	-1.1
Allergy	0.2	0.5	0.6	-0.7	0.8	0.6	0.6
Pain all over the body in last month	0.0	0.1	0.2	0.0	-0.0	0.2	0.4
Diabetes (self-reported)	0.2	0.3	0.9	0.6	0.2	-0.9	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.3	1.1	0.1	-0.6	-0.7
Medication: Ramipril	2.9	3.7	6.0	-0.6	-1.6	-2.5	-2.4
Medication: Simvastatin	6.7	9.8	18.9	1.1	-2.2	-3.8	-4.3
Fluid intelligence score	0.3	0.7	2.2	-0.4	-1.5	-0.5	-0.4
Illnesses of siblings	0.3	0.4	1.0	-0.6	0.1	0.6	1.0
Neuroticism score	0.3	0.6	1.2	1.1	-0.2	-0.6	-0.8
Weight	0.1	0.6	1.7	-1.3	0.1	-0.7	-0.2
Impedance of arm (right)	0.6	2.7	6.1	-0.7	-2.5	-1.1	-1.7
Arm fat percentage (right)	0.1	0.2	0.4	-0.3	0.6	0.3	0.6
Trunk fat-free mass	0.1	0.6	0.8	-0.9	0.9	-0.8	-0.2
Hip circumference	0.1	0.5	0.9	-1.0	-0.5	-0.8	-0.5
Time employed in main current job	0.2	0.2	0.3	-0.6	0.5	-0.1	0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	-0.7	-0.5	-0.1
Father’s age at death	0.3	0.3	1.0	-0.3	-0.3	1.0	0.4
Worrier / anxious feelings	0.3	0.5	1.1	1.1	0.7	0.6	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	1.5	0.1	-0.5	-0.7
Falls in the last year	0.4	0.6	1.2	1.1	0.4	0.8	0.4
Hair/balding pattern: Pattern 3	1.5	2.2	3.0	1.7	1.7	0.8	1.6
Number of live births	0.4	0.5	1.6	1.3	0.3	0.4	0.6
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.4	0.5	-0.1	-0.2
Pulse rate	0.4	0.6	1.3	0.2	-0.0	1.1	1.0
Happiness	0.4	0.5	1.0	0.3	-0.8	1.0	0.5
Noisy workplace	0.6	0.7	1.1	-1.1	0.6	0.8	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	-0.7	-1.2	-0.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	3.8	-0.7	-1.4	-1.9	-1.6
Mouth/teeth dental problems: Dentures	0.9	1.5	2.9	0.1	1.7	0.8	1.5
Asthma	0.1	0.2	0.3	0.4	0.2	-0.6	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	4.1	0.8	0.9	2.0	1.7
Medication: Cholesterol lowering	2.9	4.6	8.0	1.0	-1.3	-2.7	-2.8
Depression (self-reported)	0.3	0.4	0.4	0.6	-0.7	-0.6	-0.7
Medication: Lansoprazole	0.8	0.9	2.5	1.6	0.9	0.3	0.4
Prospective memory result	0.6	0.8	1.3	0.6	1.1	0.5	1.1
Lung cancer (father)	0.2	0.3	1.0	0.3	0.1	-1.0	-0.1
Illnesses of mother	8.0	9.9	17.6	1.0	2.8	4.2	3.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.0	0.3	-0.6	-0.8
Pulse wave Arterial Stiffness index	1.0	1.2	3.5	0.3	-0.5	-1.9	-1.0
Impedance of arm (left)	0.8	3.8	9.5	-1.5	-3.1	-1.0	-1.6
Arm fat mass (right)	0.1	0.2	0.3	-0.5	0.5	0.1	0.5
Trunk predicted mass	0.1	0.5	0.8	-0.9	0.9	-0.7	-0.2
Standing height	0.8	8.3	10.0	-2.9	-3.2	-2.7	-2.7
Length of working week for main job	0.1	0.2	0.3	0.5	0.3	-0.4	-0.3
Exposure to tobacco smoke at home	1.3	1.5	4.1	2.0	1.3	-0.1	-0.1
Breastfed as a baby	0.1	0.1	0.3	0.6	0.2	-0.0	0.4
Tense / ‘highly strung’	0.5	0.9	3.3	1.8	0.1	-0.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.3	-0.2	0.4	0.2
Hair/balding pattern: Pattern 4	0.3	0.6	1.4	1.1	1.2	-0.0	-0.1
Birth weight of first child	1.5	2.7	4.6	-1.8	-2.1	-1.1	-1.4
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.5	0.2	-0.5	-0.3
Pulse wave reflection index	0.1	0.2	0.3	0.5	0.4	-0.3	0.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	0.3	1.1	0.6	1.5
Loud music exposure frequency	0.4	0.5	0.9	-0.1	-0.7	0.7	1.0
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.3	-0.6	-1.4	-1.8	-1.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	5.6	2.4	-0.2	-0.2	-0.4
Blood clot in the leg (DVT)	4.2	5.4	8.0	1.8	2.3	2.8	2.2
Medication: Paracetamol	0.2	0.3	0.6	0.7	-0.6	-0.2	-0.5
Headache pain in last month	0.4	0.6	1.0	0.9	-0.8	-0.4	-1.0
Medication for cholesterol, blood pressure or diabetes	2.8	4.6	7.2	0.6	2.0	2.6	2.7
Glaucoma (self-reported)	1.1	1.3	1.9	-0.8	-1.4	-1.2	-1.1
Gout (self-reported)	4.3	5.9	10.1	-0.3	-2.8	-3.2	-2.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.7	0.5	-0.4	-0.3
Medication: Amlodipine	1.0	1.4	2.2	-0.4	-1.5	-1.1	-1.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.5	0.1	-1.2	-0.7	-0.8
Birth weight	0.0	0.1	0.3	-0.3	0.2	0.1	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.0	0.9	-0.1	-0.1
High blood pressure (siblings)	2.1	3.1	4.9	-0.4	-1.8	-2.0	-2.2
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.4
Body fat percentage	0.1	0.3	0.9	-0.9	-0.5	-0.3	0.0
Leg fat percentage (right)	0.2	0.7	1.5	-0.9	0.4	0.6	1.2
Arm fat-free mass (right)	0.1	0.4	0.6	-0.8	0.7	-0.8	-0.0
Exposure to tobacco smoke outside home	0.7	1.0	2.1	1.3	1.5	-0.1	-0.1
Comparative body size at age 10	0.3	0.8	1.5	-0.1	-0.8	-1.2	-1.1
Number of full brothers	0.2	0.2	0.9	-1.0	0.2	-0.0	0.0
Worry too long after embarrassment	0.3	0.4	1.2	0.2	-0.1	-0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	1.9	0.5	1.2	1.4	1.2
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	0.5	0.5	-0.0	-0.1
Number of children fathered	1.8	2.1	4.0	-1.5	0.7	1.3	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	0.3	-1.3	0.6	0.2
Age at first live birth	0.2	0.3	0.6	-0.4	-0.7	0.4	0.4
Pulse wave peak to peak time	0.5	0.6	2.0	-0.5	0.2	1.4	0.5
Health satisfaction	0.4	0.5	0.8	-0.5	-0.1	0.9	0.9
Shortness of breath walking on level ground	0.1	0.1	0.3	0.5	0.2	-0.1	0.1
Qualifications: College or University degree	0.7	2.3	5.1	-1.4	-2.2	-0.6	-1.4
Eye problems/disorders: None of the above	0.4	0.4	1.5	0.5	1.2	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	0.9	0.5	-0.6	-0.5
Emphysema/chronic bronchitis	0.9	1.0	2.6	1.6	0.4	0.7	1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.7	-1.3	0.3	0.1	0.4
Neck or shoulder pain in last month	2.8	4.0	5.6	1.1	2.1	2.4	2.1
Medication: Blood pressure	1.6	2.8	4.4	-0.4	-1.5	-2.1	-2.1
Angina (self-reported)	0.6	0.7	1.5	1.0	0.4	-1.2	-0.6
Migraine (self-reported)	0.9	1.2	1.7	-0.9	1.0	1.0	1.3
Medication: Ibuprofen	0.7	0.9	1.6	0.2	0.5	1.2	1.3
Medication: Allopurinol	4.1	5.5	9.3	-0.6	-2.4	-3.0	-2.6
Medication: Omeprazole	1.2	1.4	2.6	1.0	1.6	1.0	0.9
Medication: Seretide 50 evohaler	0.2	0.2	0.6	0.8	0.2	-0.1	-0.1
Mean time to correctly identify matches	0.2	0.3	0.7	0.8	0.1	0.2	-0.9
Heart disease (mother)	0.2	0.2	0.5	0.0	-0.2	-0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.6	0.0	0.0	0.5
Whole body fat mass	0.1	0.3	1.0	-1.0	-0.0	-0.4	0.0
Leg fat mass (right)	0.1	0.4	1.1	-1.0	0.4	-0.1	0.5
Arm predicted mass (right)	0.1	0.4	0.6	-0.8	0.8	-0.7	-0.1
Pulse rate, automated reading	0.2	0.5	1.7	1.3	0.4	-0.4	0.1
Alcohol intake frequency.	0.2	0.5	0.6	-0.6	-0.7	-0.7	-0.8
Comparative height size at age 10	0.4	2.2	4.0	-1.1	-0.9	-2.0	-1.7
Number of full sisters	1.5	1.8	5.6	2.4	1.0	-0.7	-0.1
Suffer from ‘nerves’	0.5	0.8	3.0	1.7	0.4	0.4	0.2
Overall health rating	0.4	0.9	3.1	1.8	0.4	-0.4	-0.4
Chest pain or discomfort	1.2	1.7	3.2	-0.3	-1.8	-1.0	-1.5
Had major operations	0.6	0.7	0.9	0.9	-0.8	-0.9	-0.6
Age at last live birth	0.8	1.1	2.0	0.5	0.6	1.4	1.3
Family relationship satisfaction	0.4	0.5	1.1	1.1	0.3	0.6	0.7
Leg pain on walking	2.2	2.8	7.4	-0.1	0.8	1.8	2.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	0.4	0.4	0.1	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.9	0.7	0.3	0.6	0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.2	0.8	0.5	0.6
Medication: Aspirin	0.6	0.8	1.4	0.9	-0.5	-1.2	-1.0
Supplements: Vitamin C	1.3	1.6	3.6	1.9	1.6	0.3	-0.0
Knee pain experienced in last month	1.8	2.8	3.9	-0.3	1.9	1.9	2.0
Hypertension (Self-reported)	3.0	8.2	14.1	0.8	-2.8	-3.8	-3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.2	0.0	0.7	1.1	1.1
Illnesses of father: Heart disease	1.0	1.4	3.0	-1.7	-1.4	0.6	-0.0
Illnesses of siblings: Diabetes	1.1	1.3	2.0	1.4	1.4	1.0	0.6
Smoking status: Previous	0.4	0.5	0.9	1.0	0.6	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.4	-0.2	-1.6	-1.9	-1.5
Whole body fat-free mass	0.1	0.5	0.9	-0.9	0.9	-0.6	-0.2
Leg fat-free mass (right)	0.1	0.4	0.7	-0.7	0.9	-0.6	-0.2
Arm fat percentage (left)	0.1	0.3	0.5	-0.5	0.4	0.4	0.7
Average weekly red wine intake	0.3	0.4	0.6	0.3	-0.7	-0.8	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.3	-0.1	0.7	-0.4
Mood swings	0.9	1.6	2.1	1.4	-0.4	-1.4	-1.4
Loneliness, isolation	0.3	0.4	0.9	-1.0	0.0	0.3	0.8
Long-standing illness, disability or infirmity	0.6	0.9	2.4	1.6	0.9	-0.5	-0.3
Ever had bowel cancer screening	0.3	0.3	0.6	-0.4	-0.3	-0.6	-0.8
Diabetes diagnosed by doctor	0.5	0.8	1.6	0.9	0.4	-1.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	-0.5	-0.4	-0.2
Friendships satisfaction	0.7	0.8	2.9	1.7	0.6	-0.1	0.1
Qualifications: nursing, teaching	2.0	3.2	6.5	-1.4	-2.6	-1.5	-1.4
Commuting to job workplace: Walk	1.3	1.4	1.8	-0.7	1.3	1.3	1.3
Eye problems/disorders: Cataract	0.6	0.7	1.4	0.0	-0.7	-1.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	0.6	0.7	0.9	0.4
Medication for cholesterol	3.7	5.6	7.7	-0.0	2.8	2.7	2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.4	1.2	0.7	0.3	0.5
Back pain experienced in last month	3.0	4.4	8.2	-0.7	1.4	2.9	2.7
Mineral and other dietary supplements	1.2	1.6	2.0	-1.3	-0.8	-1.4	-1.4
Breast cancer (self-reported)	1.5	1.8	5.1	2.3	1.0	0.9	0.5
Asthma (self-reported)	0.1	0.2	0.4	0.1	-0.0	-0.6	-0.5
Osteoporosis (self-reported)	0.1	0.2	0.4	-0.6	-0.4	0.3	-0.0
Osteoarthritis (self-reported)	1.2	1.6	2.6	0.5	1.2	1.4	1.6
Medication: Aspirin	0.7	0.9	1.7	1.3	-0.1	-1.0	-0.9
Medication: Gliclazide	1.6	1.8	5.6	0.7	2.4	0.5	0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	1.9	0.7	1.4	0.0	0.3
Smoking status: Current	1.0	1.6	1.9	1.2	1.3	1.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.6	1.0	1.3	0.9	0.9
Whole body water mass	0.1	0.6	1.0	-1.0	1.0	-0.6	-0.1
Leg predicted mass (right)	0.1	0.4	0.7	-0.7	0.9	-0.6	-0.2
Arm fat mass (left)	0.1	0.3	0.5	-0.7	0.4	0.2	0.6
Number of self-reported non-cancer illnesses	1.5	2.6	4.2	1.0	-1.4	-2.1	-1.9
Average weekly champagne plus white wine intake	1.5	2.1	5.1	2.2	0.2	-1.3	-1.2
Miserableness	0.7	1.2	4.6	2.1	0.2	-0.2	-0.4
Guilty feelings	1.0	1.4	3.3	-1.8	-1.3	-0.3	-0.8
Wears glasses or contact lenses	0.7	0.8	1.6	-0.2	0.1	1.3	1.3
Ever taken oral contraceptive pill	5.7	6.3	8.9	1.6	2.4	3.0	2.9
Hearing aid user	0.7	0.8	1.6	-0.5	-1.3	-1.0	-0.6
Mother’s age at death	1.1	1.4	2.2	-1.5	-0.6	1.0	1.4
Financial situation satisfaction	0.3	0.4	0.7	-0.4	-0.8	-0.8	-0.2
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.0	-1.3	0.5	2.0	1.5
Commuting to job workplace: Public transport	0.4	0.5	0.9	-0.7	-0.9	-0.0	-0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.3	-0.6	-0.5	-0.4
Medication: Blood pressure	3.2	6.1	8.9	-0.4	-2.8	-3.0	-2.8
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.3	2.1	2.0	0.4	0.6
Supplements: Fish oil (including cod liver oil)	3.7	4.8	7.9	1.2	1.5	2.7	2.8
High cholesterol (Self-reported)	6.5	11.6	21.5	-0.1	-2.9	-4.1	-4.6
Medication: Bendroflumethiazide	1.3	2.0	3.6	-0.4	-1.8	-1.9	-1.1
Medication: Paracetamol	0.6	0.9	1.7	0.8	-1.3	-0.7	-0.9
Medication: Lisinopril	1.4	1.9	3.6	-0.1	-1.3	-1.5	-1.9
Medication: Atorvastatin	0.3	0.3	0.6	0.3	-0.6	-0.8	-0.6
Illnesses of father: High blood pressure	1.3	1.6	2.3	1.5	-0.4	-1.4	-1.4
Alcohol drinker status: Never	0.7	0.9	1.3	1.0	0.8	-1.1	-0.8
Ever smoked	0.8	1.4	5.0	2.2	0.6	-0.3	-0.3
Basal metabolic rate	0.1	0.5	1.0	-1.0	0.7	-0.7	-0.2
Leg fat percentage (left)	0.1	0.3	0.8	-0.5	0.4	0.3	0.9
Arm fat-free mass (left)	0.1	0.5	0.9	-0.6	1.0	-0.8	-0.1
Number of operations (self-reported)	0.4	0.6	1.5	-0.3	-1.2	-0.8	-0.3
Average weekly beer plus cider intake	1.7	2.4	6.2	2.5	-0.9	-1.0	-1.3
Irritability	1.9	3.2	5.2	1.7	1.5	2.3	1.7
Risk taking	0.8	1.2	2.1	0.8	0.4	1.4	1.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.0	-1.4	-0.2	0.7	-0.3
Fractured/broken bones in last 5 years	2.1	2.7	3.4	1.8	1.9	1.6	1.3
Age started oral contraceptive pill	0.5	0.6	0.9	-1.0	0.5	0.6	1.0
Diastolic blood pressure, automated reading	1.1	3.4	6.2	1.7	-0.7	-2.5	-2.0
Ever depressed for a whole week	0.8	1.0	1.3	1.0	-0.6	-1.1	-1.2
Unable to work because of sickness or disability	0.6	0.8	1.1	0.7	0.7	1.0	1.1
Commuting to job workplace: Cycle	3.2	3.9	6.0	-1.2	-2.4	-1.7	-2.3
Myopia	0.6	0.9	2.3	-0.1	-1.5	-0.9	-0.8
Vascular/heart problems diagnosed by doctor	3.8	10.4	16.6	-1.6	2.9	4.1	3.8
Cholesterol lowering medication	5.2	7.7	14.0	0.5	-2.3	-3.4	-3.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	0.9	1.0	0.6	0.2
Pain experienced in last month	0.9	1.5	2.5	-0.2	-1.3	-1.6	-1.3
Supplements: Calcium	1.5	1.7	3.7	1.5	1.9	0.8	0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.7	0.3	-0.2	-0.3
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.0	1.7	1.2	-0.9	-1.0
Deep venous thrombosis (DVT) (self-reported)	4.5	5.8	9.5	1.6	2.2	3.1	2.5
Heart disease (siblings)	1.3	1.6	2.5	1.3	1.6	1.0	1.2
Alcohol drinker status: Previous	0.2	0.3	0.7	-0.4	-0.8	-0.3	-0.5
Pack years of smoking	0.3	0.4	1.1	0.2	0.1	-1.0	-0.7
Impedance of whole body	0.7	3.8	10.3	-0.7	-3.2	-1.2	-1.7
Leg fat mass (left)	0.1	0.2	0.6	-0.8	0.4	-0.3	0.3
Arm predicted mass (left)	0.1	0.5	1.1	-0.5	0.7	-1.0	-0.3