TWAS hub - SYTL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.5880	0.1050	3.1e-04	0.047	NA	0.021	NA	0.097	2.4e-02	NA	9.2e-02	NA	1.8e-03
2	GTEx	Brain Cerebellum	0.3320	0.1170	1.5e-03	0.063	NA	0.128	NA	0.158	6.3e-03	NA	1.3e-04	NA	2.1e-05
3	GTEx	Esophagus Mucosa	0.0980	0.0530	8.9e-03	0.032	NA	0.043	NA	0.044	3.0e-03	NA	7.5e-04	NA	6.1e-04
4	YFS	Blood	0.0713	0.0225	2.3e-07	0.035	0.03	0.030	0.029	0.031	1.7e-11	3.4e-10	3.0e-10	5.8e-10	1.4e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Illnesses of mother	8.0	9.9	17.6	1.0	2.8	4.2	3.6
Medication: Simvastatin	6.7	9.8	18.9	1.1	-2.2	-3.8	-4.3
High cholesterol (Self-reported)	6.5	11.6	21.5	-0.1	-2.9	-4.1	-4.6
Ever taken oral contraceptive pill	5.7	6.3	8.9	1.6	2.4	3.0	2.9
Cholesterol lowering medication	5.2	7.7	14.0	0.5	-2.3	-3.4	-3.7
Cardiovascular Disease	4.9	16.1	23.2	-0.3	-4.6	-4.8	-4.5
High blood pressure (mother)	4.8	6.7	12.5	-0.7	-2.0	-3.5	-3.1
Deep venous thrombosis (DVT) (self-reported)	4.5	5.8	9.5	1.6	2.2	3.1	2.5
Gout (self-reported)	4.3	5.9	10.1	-0.3	-2.8	-3.2	-2.4
Blood clot in the leg (DVT)	4.2	5.4	8.0	1.8	2.3	2.8	2.2
Medication: Allopurinol	4.1	5.5	9.3	-0.6	-2.4	-3.0	-2.6
Vascular/heart problems diagnosed by doctor	3.8	10.4	16.6	-1.6	2.9	4.1	3.8
Medication for cholesterol	3.7	5.6	7.7	-0.0	2.8	2.7	2.8
Supplements: Fish oil (including cod liver oil)	3.7	4.8	7.9	1.2	1.5	2.7	2.8
Diabetes (mother)	3.6	4.6	8.8	-0.2	-1.3	-2.8	-3.0
High blood pressure	3.5	9.9	16.8	1.4	-2.9	-4.1	-3.6
Mean Putamen Volume	3.2	3.6	4.9	-2.0	-2.2	-1.3	-1.9
Medication: Blood pressure	3.2	6.1	8.9	-0.4	-2.8	-3.0	-2.8
Commuting to job workplace: Cycle	3.2	3.9	6.0	-1.2	-2.4	-1.7	-2.3
HDL Cholesterol	3.1	5.2	7.4	1.1	2.3	2.7	2.7
Hypertension (Self-reported)	3.0	8.2	14.1	0.8	-2.8	-3.8	-3.2
Back pain experienced in last month	3.0	4.4	8.2	-0.7	1.4	2.9	2.7
Medication: Ramipril	2.9	3.7	6.0	-0.6	-1.6	-2.5	-2.4
Medication: Cholesterol lowering	2.9	4.6	8.0	1.0	-1.3	-2.7	-2.8
Systolic blood pressure, automated reading	2.8	8.1	14.3	0.8	-2.0	-3.8	-3.7
Medication for cholesterol, blood pressure or diabetes	2.8	4.6	7.2	0.6	2.0	2.6	2.7
Neck or shoulder pain in last month	2.8	4.0	5.6	1.1	2.1	2.4	2.1
Blood Platelet Count	2.6	30.3	41.0	-0.8	-6.4	-6.2	-6.4
LDL Cholesterol	2.5	3.9	5.8	-1.2	-2.4	-2.2	-1.8
Systolic Blood Pressure	2.5	12.6	21.2	1.2	-2.9	-4.6	-4.4
Schizophrenia (2014)	2.3	5.0	8.0	2.1	2.8	0.0	2.8
Medication: Co-codamol	2.2	2.6	5.4	1.1	2.3	1.4	1.3
Leg pain on walking	2.2	2.8	7.4	-0.1	0.8	1.8	2.7
High blood pressure (siblings)	2.1	3.1	4.9	-0.4	-1.8	-2.0	-2.2
Fractured/broken bones in last 5 years	2.1	2.7	3.4	1.8	1.9	1.6	1.3
Schizophrenia (2018)	2.0	4.1	7.3	1.7	2.5	0.0	2.7
Qualifications: nursing, teaching	2.0	3.2	6.5	-1.4	-2.6	-1.5	-1.4
Blood Eosinophil Count	1.9	14.4	24.1	0.6	-3.2	-4.9	-4.8
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	3.8	-0.7	-1.4	-1.9	-1.6
Irritability	1.9	3.2	5.2	1.7	1.5	2.3	1.7
Number of children fathered	1.8	2.1	4.0	-1.5	0.7	1.3	2.0
Knee pain experienced in last month	1.8	2.8	3.9	-0.3	1.9	1.9	2.0
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.0	-1.3	0.5	2.0	1.5
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.3	2.1	2.0	0.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	9.6	3.1	0.4	-0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	4.1	0.8	0.9	2.0	1.7
Average weekly beer plus cider intake	1.7	2.4	6.2	2.5	-0.9	-1.0	-1.3
Medication: Atenolol	1.6	2.0	3.4	0.5	-1.0	-1.8	-1.9
Number of incorrect matches in round	1.6	2.7	4.9	-0.3	1.3	2.0	2.2
Medication: Blood pressure	1.6	2.8	4.4	-0.4	-1.5	-2.1	-2.1
Medication: Gliclazide	1.6	1.8	5.6	0.7	2.4	0.5	0.9
Hair/balding pattern: Pattern 3	1.5	2.2	3.0	1.7	1.7	0.8	1.6
Birth weight of first child	1.5	2.7	4.6	-1.8	-2.1	-1.1	-1.4
Number of full sisters	1.5	1.8	5.6	2.4	1.0	-0.7	-0.1
Breast cancer (self-reported)	1.5	1.8	5.1	2.3	1.0	0.9	0.5
Number of self-reported non-cancer illnesses	1.5	2.6	4.2	1.0	-1.4	-2.1	-1.9
Average weekly champagne plus white wine intake	1.5	2.1	5.1	2.2	0.2	-1.3	-1.2
Supplements: Calcium	1.5	1.7	3.7	1.5	1.9	0.8	0.2
Chronotype (morning person)	1.4	3.3	4.4	-1.0	2.0	2.0	2.1
Sensitivity / hurt feelings	1.4	2.4	4.4	1.0	-0.3	-2.1	-2.1
Medication: Lisinopril	1.4	1.9	3.6	-0.1	-1.3	-1.5	-1.9
Townsend deprivation index at recruitment	1.3	1.9	3.8	1.9	2.0	0.5	0.2
Chronic bronchitis/emphysema (father)	1.3	1.6	3.0	0.4	1.2	1.3	1.7
Exposure to tobacco smoke at home	1.3	1.5	4.1	2.0	1.3	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.3	-0.6	-1.4	-1.8	-1.6
Supplements: Vitamin C	1.3	1.6	3.6	1.9	1.6	0.3	-0.0
Commuting to job workplace: Walk	1.3	1.4	1.8	-0.7	1.3	1.3	1.3
Medication: Bendroflumethiazide	1.3	2.0	3.6	-0.4	-1.8	-1.9	-1.1
Illnesses of father: High blood pressure	1.3	1.6	2.3	1.5	-0.4	-1.4	-1.4
Heart disease (siblings)	1.3	1.6	2.5	1.3	1.6	1.0	1.2
Bipolar Disorder or Schizophrenia	1.2	3.0	4.3	2.0	2.1	0.0	1.9
HbA1C	1.2	1.4	4.9	-2.2	-0.7	0.2	-0.0
Heel T-Score	1.2	9.9	22.4	-3.8	-4.7	-1.4	-0.8
Number of treatments/medications taken	1.2	2.1	6.6	-0.3	-2.6	-0.9	-0.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.1	1.4	0.1	-1.1	-1.4
Hearing difficulty/problems with background noise	1.2	2.0	2.9	-0.0	1.5	1.7	1.6
Heart attack	1.2	1.5	2.8	1.7	0.9	-1.0	-1.1
Medication: Omeprazole	1.2	1.4	2.6	1.0	1.6	1.0	0.9
Chest pain or discomfort	1.2	1.7	3.2	-0.3	-1.8	-1.0	-1.5
Mineral and other dietary supplements	1.2	1.6	2.0	-1.3	-0.8	-1.4	-1.4
Osteoarthritis (self-reported)	1.2	1.6	2.6	0.5	1.2	1.4	1.6
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.0	1.7	1.2	-0.9	-1.0
Alzheimer’s Disease (in mother)	1.1	1.2	1.9	0.2	-1.3	-1.1	-1.4
Primary Biliary Cirrhosis	1.1	1.6	3.0	0.0	1.2	1.7	1.4
Hearing difficulty/problems: Yes	1.1	1.7	3.3	-1.2	0.6	1.8	1.3
Current tobacco smoking	1.1	1.8	2.2	1.4	1.3	1.5	1.3
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	5.6	2.4	-0.2	-0.2	-0.4
Glaucoma (self-reported)	1.1	1.3	1.9	-0.8	-1.4	-1.2	-1.1
Illnesses of siblings: Diabetes	1.1	1.3	2.0	1.4	1.4	1.0	0.6
Mother’s age at death	1.1	1.4	2.2	-1.5	-0.6	1.0	1.4
Diastolic blood pressure, automated reading	1.1	3.4	6.2	1.7	-0.7	-2.5	-2.0
Height	1.0	19.6	24.8	-2.8	-4.8	-5.0	-4.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.5	0.9	0.5	1.2	1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	1.0	1.4	0.9	0.9
Pulse wave Arterial Stiffness index	1.0	1.2	3.5	0.3	-0.5	-1.9	-1.0
Medication: Amlodipine	1.0	1.4	2.2	-0.4	-1.5	-1.1	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	1.9	0.5	1.2	1.4	1.2
Illnesses of father: Heart disease	1.0	1.4	3.0	-1.7	-1.4	0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.4	-0.2	-1.6	-1.9	-1.5
Smoking status: Current	1.0	1.6	1.9	1.2	1.3	1.4	1.1
Guilty feelings	1.0	1.4	3.3	-1.8	-1.3	-0.3	-0.8
Alzheimer’s Disease (including proxy)	0.9	1.3	2.1	0.7	-1.0	-1.3	-1.4
Stomach or abdominal pain in last month	0.9	1.1	3.0	-0.6	0.4	1.7	0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	1.5	-0.1	-1.2	-0.7
Mouth/teeth dental problems: Dentures	0.9	1.5	2.9	0.1	1.7	0.8	1.5
Emphysema/chronic bronchitis	0.9	1.0	2.6	1.6	0.4	0.7	1.0
Migraine (self-reported)	0.9	1.2	1.7	-0.9	1.0	1.0	1.3
Mood swings	0.9	1.6	2.1	1.4	-0.4	-1.4	-1.4
Pain experienced in last month	0.9	1.5	2.5	-0.2	-1.3	-1.6	-1.3
Age at First Birth	0.8	1.2	3.5	-1.9	0.0	1.0	0.6
Neuroticism (2016)	0.8	1.1	1.7	-1.0	-1.3	-1.0	-0.8
Allergy or Eczema	0.8	2.2	3.8	-1.0	-1.9	-1.6	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.5	-0.5	-1.9	-1.2	-1.4
Impedance of leg (left)	0.8	3.7	8.4	-0.2	-2.9	-1.7	-1.9
Medication: Lansoprazole	0.8	0.9	2.5	1.6	0.9	0.3	0.4
Impedance of arm (left)	0.8	3.8	9.5	-1.5	-3.1	-1.0	-1.6
Standing height	0.8	8.3	10.0	-2.9	-3.2	-2.7	-2.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	0.3	1.1	0.6	1.5
Age at last live birth	0.8	1.1	2.0	0.5	0.6	1.4	1.3
Ever smoked	0.8	1.4	5.0	2.2	0.6	-0.3	-0.3
Risk taking	0.8	1.2	2.1	0.8	0.4	1.4	1.4
Ever depressed for a whole week	0.8	1.0	1.3	1.0	-0.6	-1.1	-1.2
Worry (Nagel 2018)	0.7	1.5	4.8	2.2	1.1	0.2	0.4
Breast Cancer	0.7	1.7	5.5	-2.3	-0.2	-0.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	1.4	-0.5	-0.2	-1.1
Multivitamins +/- minerals	0.7	0.9	1.7	0.7	1.3	0.8	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	-1.0	-0.3	1.4	0.5
Past tobacco smoking	0.7	1.3	3.7	-1.9	-1.1	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.3	-0.8	-2.1	-0.8	-1.0
Mouth/teeth dental problems	0.7	1.1	2.6	-1.6	-1.0	-0.5	-0.8
Exposure to tobacco smoke outside home	0.7	1.0	2.1	1.3	1.5	-0.1	-0.1
Qualifications: College or University degree	0.7	2.3	5.1	-1.4	-2.2	-0.6	-1.4
Medication: Ibuprofen	0.7	0.9	1.6	0.2	0.5	1.2	1.3
Friendships satisfaction	0.7	0.8	2.9	1.7	0.6	-0.1	0.1
Medication: Aspirin	0.7	0.9	1.7	1.3	-0.1	-1.0	-0.9
Miserableness	0.7	1.2	4.6	2.1	0.2	-0.2	-0.4
Wears glasses or contact lenses	0.7	0.8	1.6	-0.2	0.1	1.3	1.3
Hearing aid user	0.7	0.8	1.6	-0.5	-1.3	-1.0	-0.6
Alcohol drinker status: Never	0.7	0.9	1.3	1.0	0.8	-1.1	-0.8
Impedance of whole body	0.7	3.8	10.3	-0.7	-3.2	-1.2	-1.7
Depression (Nagel 2018)	0.6	0.9	1.4	1.2	-0.2	-0.9	-1.1
Fasting Glucose	0.6	0.7	1.8	-0.2	-0.7	-0.6	-1.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	1.1	-0.3	-0.8	-1.1
Medication: Metformin	0.6	0.8	2.0	1.4	1.1	-0.3	-0.0
Impedance of leg (right)	0.6	2.7	7.3	-0.8	-2.7	-1.2	-1.3
Fed-up feelings	0.6	1.1	1.7	1.3	-0.5	-1.1	-1.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.0	-0.3	-1.4	-1.3	-1.1
Nervous feelings	0.6	1.2	1.6	1.2	-0.2	-1.2	-1.3
Impedance of arm (right)	0.6	2.7	6.1	-0.7	-2.5	-1.1	-1.7
Noisy workplace	0.6	0.7	1.1	-1.1	0.6	0.8	0.8
Prospective memory result	0.6	0.8	1.3	0.6	1.1	0.5	1.1
Angina (self-reported)	0.6	0.7	1.5	1.0	0.4	-1.2	-0.6
Had major operations	0.6	0.7	0.9	0.9	-0.8	-0.9	-0.6
Medication: Aspirin	0.6	0.8	1.4	0.9	-0.5	-1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.2	0.0	0.7	1.1	1.1
Long-standing illness, disability or infirmity	0.6	0.9	2.4	1.6	0.9	-0.5	-0.3
Eye problems/disorders: Cataract	0.6	0.7	1.4	0.0	-0.7	-1.2	-0.9
Medication: Paracetamol	0.6	0.9	1.7	0.8	-1.3	-0.7	-0.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.0	-1.4	-0.2	0.7	-0.3
Unable to work because of sickness or disability	0.6	0.8	1.1	0.7	0.7	1.0	1.1
Myopia	0.6	0.9	2.3	-0.1	-1.5	-0.9	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	-0.6	1.1	0.0	1.0
Alzheimer’s Disease (in father)	0.5	0.5	0.9	0.2	-0.5	-0.9	-1.0
Reaction Time	0.5	1.0	2.9	1.7	0.7	0.5	-0.6
Prostate Cancer	0.5	0.7	2.0	-0.3	1.4	0.4	0.8
Lupus	0.5	0.7	1.3	0.8	0.1	1.1	1.0
Relative age of first facial hair	0.5	1.1	1.9	1.0	-1.4	-0.9	-0.8
Vitamin and mineral supplements	0.5	0.7	1.2	-0.6	-1.1	-0.8	-0.7
Financial difficulties in last 2 years	0.5	0.6	1.9	1.4	0.6	-0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	1.5	0.1	-0.5	-0.7
Tense / ‘highly strung’	0.5	0.9	3.3	1.8	0.1	-0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.5	0.1	-1.2	-0.7	-0.8
Pulse wave peak to peak time	0.5	0.6	2.0	-0.5	0.2	1.4	0.5
Suffer from ‘nerves’	0.5	0.8	3.0	1.7	0.4	0.4	0.2
Diabetes diagnosed by doctor	0.5	0.8	1.6	0.9	0.4	-1.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.4	1.2	0.7	0.3	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.9	0.7	1.4	0.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.6	1.0	1.3	0.9	0.9
Age started oral contraceptive pill	0.5	0.6	0.9	-1.0	0.5	0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	0.9	1.0	0.6	0.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.2	0.0	-1.5	-1.4	-1.1
Major Depression (MDD)	0.4	0.5	1.9	-0.5	0.0	0.0	1.4
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	-1.0	-0.1	0.9	0.8
Average weekly spirits intake	0.4	0.5	1.1	1.0	0.7	0.2	0.7
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.8	-0.9	0.0	0.2
Angina	0.4	0.5	1.0	0.8	0.4	-1.0	-0.4
Taking other prescription medications	0.4	0.5	0.7	0.8	-0.9	-0.6	-0.7
Sitting height	0.4	2.6	3.2	-1.7	-1.4	-1.8	-1.6
Alcohol usually taken with meals	0.4	0.6	1.8	-1.4	-0.7	-0.2	-0.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.3	1.1	0.1	-0.6	-0.7
Falls in the last year	0.4	0.6	1.2	1.1	0.4	0.8	0.4
Number of live births	0.4	0.5	1.6	1.3	0.3	0.4	0.6
Pulse rate	0.4	0.6	1.3	0.2	-0.0	1.1	1.0
Happiness	0.4	0.5	1.0	0.3	-0.8	1.0	0.5
Loud music exposure frequency	0.4	0.5	0.9	-0.1	-0.7	0.7	1.0
Headache pain in last month	0.4	0.6	1.0	0.9	-0.8	-0.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	0.3	-1.3	0.6	0.2
Health satisfaction	0.4	0.5	0.8	-0.5	-0.1	0.9	0.9
Eye problems/disorders: None of the above	0.4	0.4	1.5	0.5	1.2	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	0.9	0.5	-0.6	-0.5
Comparative height size at age 10	0.4	2.2	4.0	-1.1	-0.9	-2.0	-1.7
Overall health rating	0.4	0.9	3.1	1.8	0.4	-0.4	-0.4
Family relationship satisfaction	0.4	0.5	1.1	1.1	0.3	0.6	0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.9	0.7	0.3	0.6	0.9
Smoking status: Previous	0.4	0.5	0.9	1.0	0.6	0.6	0.8
Commuting to job workplace: Public transport	0.4	0.5	0.9	-0.7	-0.9	-0.0	-0.8
Number of operations (self-reported)	0.4	0.6	1.5	-0.3	-1.2	-0.8	-0.3
Crohns Disease (2012)	0.3	0.5	1.0	-0.5	1.0	0.8	0.6
Smoking Status	0.3	0.7	1.1	0.8	0.6	1.0	0.9
Lung FVC	0.3	1.6	3.0	-0.2	1.4	1.7	1.1
Diabetes (father)	0.3	0.3	1.2	1.1	0.1	-0.3	-0.2
Severe depression (siblings)	0.3	0.3	1.0	1.0	0.1	0.5	-0.1
Pack years adult smoking proportion	0.3	0.4	1.1	-0.0	-0.2	-1.0	-0.7
Average weekly fortified wine intake	0.3	0.3	1.1	-0.0	1.0	-0.0	0.4
Maternal smoking around birth	0.3	0.5	1.1	1.1	0.6	-0.2	-0.5
Supplements: Glucosamine	0.3	0.4	0.8	-0.5	-0.5	0.7	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.7	-0.4	0.8	0.3
Fluid intelligence score	0.3	0.7	2.2	-0.4	-1.5	-0.5	-0.4
Illnesses of siblings	0.3	0.4	1.0	-0.6	0.1	0.6	1.0
Neuroticism score	0.3	0.6	1.2	1.1	-0.2	-0.6	-0.8
Father’s age at death	0.3	0.3	1.0	-0.3	-0.3	1.0	0.4
Worrier / anxious feelings	0.3	0.5	1.1	1.1	0.7	0.6	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	-0.7	-1.2	-0.5	-0.6
Depression (self-reported)	0.3	0.4	0.4	0.6	-0.7	-0.6	-0.7
Hair/balding pattern: Pattern 4	0.3	0.6	1.4	1.1	1.2	-0.0	-0.1
Comparative body size at age 10	0.3	0.8	1.5	-0.1	-0.8	-1.2	-1.1
Worry too long after embarrassment	0.3	0.4	1.2	0.2	-0.1	-0.7	-1.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.7	-1.3	0.3	0.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.2	0.8	0.5	0.6
Average weekly red wine intake	0.3	0.4	0.6	0.3	-0.7	-0.8	-0.7
Loneliness, isolation	0.3	0.4	0.9	-1.0	0.0	0.3	0.8
Ever had bowel cancer screening	0.3	0.3	0.6	-0.4	-0.3	-0.6	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	0.6	0.7	0.9	0.4
Financial situation satisfaction	0.3	0.4	0.7	-0.4	-0.8	-0.8	-0.2
Medication: Atorvastatin	0.3	0.3	0.6	0.3	-0.6	-0.8	-0.6
Pack years of smoking	0.3	0.4	1.1	0.2	0.1	-1.0	-0.7
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	0.9	-0.3	-0.7	-0.3
Neuroticism (Nagel 2018)	0.2	0.5	2.0	1.4	0.3	0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	1.1	-0.4	-0.4	0.0
Rheumatoid Arthritis	0.2	0.2	0.5	-0.4	0.3	0.7	0.3
Blood Red Count	0.2	2.2	3.5	-1.0	-1.6	-1.9	-1.2
BMI	0.2	1.0	1.6	-0.5	0.9	1.1	1.3
Waist Hip Ratio (WHR)	0.2	0.9	2.1	-0.7	-0.3	1.0	1.4
Lung FEV1/FVC ratio	0.2	0.9	1.6	0.2	1.0	1.3	1.1
Tanning	0.2	2.2	5.4	1.2	2.3	1.1	0.8
Hand grip strength (left)	0.2	0.5	0.7	-0.6	-0.8	-0.8	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.4	-0.6	0.2	0.5
Relative age voice broke	0.2	0.3	0.9	0.9	-0.2	0.4	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.4	0.2	0.6	0.5
Body mass index (BMI)	0.2	1.0	2.3	0.1	1.5	0.6	1.1
Had other major operations	0.2	0.2	0.6	-0.8	-0.4	-0.1	0.2
Qualifications: None of the above	0.2	0.5	1.7	-0.4	1.3	0.2	0.3
Allergy	0.2	0.5	0.6	-0.7	0.8	0.6	0.6
Diabetes (self-reported)	0.2	0.3	0.9	0.6	0.2	-0.9	-0.3
Time employed in main current job	0.2	0.2	0.3	-0.6	0.5	-0.1	0.6
Lung cancer (father)	0.2	0.3	1.0	0.3	0.1	-1.0	-0.1
Medication: Paracetamol	0.2	0.3	0.6	0.7	-0.6	-0.2	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.0	0.9	-0.1	-0.1
Leg fat percentage (right)	0.2	0.7	1.5	-0.9	0.4	0.6	1.2
Number of full brothers	0.2	0.2	0.9	-1.0	0.2	-0.0	0.0
Age at first live birth	0.2	0.3	0.6	-0.4	-0.7	0.4	0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.6	0.8	0.2	-0.1	-0.1
Mean time to correctly identify matches	0.2	0.3	0.7	0.8	0.1	0.2	-0.9
Heart disease (mother)	0.2	0.2	0.5	0.0	-0.2	-0.5	-0.7
Pulse rate, automated reading	0.2	0.5	1.7	1.3	0.4	-0.4	0.1
Alcohol intake frequency.	0.2	0.5	0.6	-0.6	-0.7	-0.7	-0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.3	-0.1	0.7	-0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.3	-0.6	-0.5	-0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.7	0.3	-0.2	-0.3
Alcohol drinker status: Previous	0.2	0.3	0.7	-0.4	-0.8	-0.3	-0.5
Bipolar Disorder (2018)	0.1	0.2	0.8	0.9	0.1	0.0	-0.3
Crohns Disease (2017)	0.1	0.2	0.6	0.1	0.7	0.4	0.0
Ulcerative Colitis	0.1	0.2	0.4	-0.6	-0.6	0.0	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	-0.6	-0.2	0.0	0.1
Supplements: Zinc	0.1	0.2	0.3	-0.5	0.0	-0.4	-0.4
Leg fat-free mass (left)	0.1	0.5	1.3	-1.1	0.9	-0.3	0.1
Trunk fat percentage	0.1	0.6	1.1	-1.1	-0.9	-0.5	-0.3
Hand grip strength (right)	0.1	0.4	0.6	-0.6	-0.8	-0.7	-0.3
Age when periods started (menarche)	0.1	0.2	0.4	0.5	0.1	0.3	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.6	-0.2	-0.3	-0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.6	-0.0	-0.0	0.8	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.3	-0.2	0.4	0.3
Leg predicted mass (left)	0.1	0.5	1.1	-1.0	0.9	-0.2	0.2
Trunk fat mass	0.1	0.5	1.5	-1.2	-0.4	-0.4	-0.1
Waist circumference	0.1	0.2	0.8	-0.9	0.1	-0.0	0.3
Had menopause	0.1	0.1	0.2	-0.5	0.3	-0.2	0.2
Weight	0.1	0.6	1.7	-1.3	0.1	-0.7	-0.2
Arm fat percentage (right)	0.1	0.2	0.4	-0.3	0.6	0.3	0.6
Trunk fat-free mass	0.1	0.6	0.8	-0.9	0.9	-0.8	-0.2
Hip circumference	0.1	0.5	0.9	-1.0	-0.5	-0.8	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	-0.7	-0.5	-0.1
Asthma	0.1	0.2	0.3	0.4	0.2	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.0	0.3	-0.6	-0.8
Arm fat mass (right)	0.1	0.2	0.3	-0.5	0.5	0.1	0.5
Trunk predicted mass	0.1	0.5	0.8	-0.9	0.9	-0.7	-0.2
Length of working week for main job	0.1	0.2	0.3	0.5	0.3	-0.4	-0.3
Breastfed as a baby	0.1	0.1	0.3	0.6	0.2	-0.0	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.3	-0.2	0.4	0.2
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.5	0.2	-0.5	-0.3
Pulse wave reflection index	0.1	0.2	0.3	0.5	0.4	-0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.7	0.5	-0.4	-0.3
Body fat percentage	0.1	0.3	0.9	-0.9	-0.5	-0.3	0.0
Arm fat-free mass (right)	0.1	0.4	0.6	-0.8	0.7	-0.8	-0.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	0.5	0.5	-0.0	-0.1
Shortness of breath walking on level ground	0.1	0.1	0.3	0.5	0.2	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.6	0.0	0.0	0.5
Whole body fat mass	0.1	0.3	1.0	-1.0	-0.0	-0.4	0.0
Leg fat mass (right)	0.1	0.4	1.1	-1.0	0.4	-0.1	0.5
Arm predicted mass (right)	0.1	0.4	0.6	-0.8	0.8	-0.7	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	0.4	0.4	0.1	0.6
Whole body fat-free mass	0.1	0.5	0.9	-0.9	0.9	-0.6	-0.2
Leg fat-free mass (right)	0.1	0.4	0.7	-0.7	0.9	-0.6	-0.2
Arm fat percentage (left)	0.1	0.3	0.5	-0.5	0.4	0.4	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	-0.5	-0.4	-0.2
Asthma (self-reported)	0.1	0.2	0.4	0.1	-0.0	-0.6	-0.5
Osteoporosis (self-reported)	0.1	0.2	0.4	-0.6	-0.4	0.3	-0.0
Whole body water mass	0.1	0.6	1.0	-1.0	1.0	-0.6	-0.1
Leg predicted mass (right)	0.1	0.4	0.7	-0.7	0.9	-0.6	-0.2
Arm fat mass (left)	0.1	0.3	0.5	-0.7	0.4	0.2	0.6
Basal metabolic rate	0.1	0.5	1.0	-1.0	0.7	-0.7	-0.2
Leg fat percentage (left)	0.1	0.3	0.8	-0.5	0.4	0.3	0.9
Arm fat-free mass (left)	0.1	0.5	0.9	-0.6	1.0	-0.8	-0.1
Leg fat mass (left)	0.1	0.2	0.6	-0.8	0.4	-0.3	0.3
Arm predicted mass (left)	0.1	0.5	1.1	-0.5	0.7	-1.0	-0.3
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.2
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.3	-0.3	0.2	-0.1
Ovarian Cancer	0.0	0.0	0.1	0.1	0.3	-0.1	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.1	0.1	-0.4	-0.3	-0.3	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.3	0.9	1.0	-0.3	0.2	-0.1
Hypothyroidism (self reported)	0.0	0.1	0.3	-0.1	0.1	-0.5	-0.3
Respiratory disease	0.0	0.1	0.1	-0.0	-0.3	-0.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.1	0.4	-0.3	0.2
Neuroticism	0.0	0.0	0.2	0.4	0.0	0.1	-0.0
Hair Pigment	0.0	0.6	1.9	-0.6	-1.4	-0.6	-0.0
Forced vital capacity (FVC)	0.0	0.1	0.4	-0.6	0.1	-0.1	0.0
Pain all over the body in last month	0.0	0.1	0.2	0.0	-0.0	0.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.4	0.5	-0.1	-0.2
Birth weight	0.0	0.1	0.3	-0.3	0.2	0.1	0.5
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.4

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