Hub : Genes

TACSTD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1426	0.0450	7.9e-05	0.129	NA	0.088	NA	0.101	2.8e-10	NA	2.1e-07	NA	2.7e-08
2	GTEx	Colon Sigmoid	0.2860	0.0870	2.0e-03	-0.008	NA	-0.003	NA	0.020	8.1e-01	NA	4.2e-01	NA	6.3e-02
3	GTEx	Esophagus Mucosa	0.2070	0.0500	3.6e-07	0.044	NA	0.123	NA	0.102	6.4e-04	NA	1.4e-08	NA	2.7e-07
4	GTEx	Lung	0.1457	0.0423	1.2e-05	0.091	NA	0.049	NA	0.069	1.9e-07	NA	1.2e-04	NA	5.9e-06
5	GTEx	Skin Not Sun Exposed Suprapubic	0.1580	0.0610	8.3e-03	0.001	NA	-0.002	NA	0.006	2.7e-01	NA	4.3e-01	NA	1.5e-01
6	GTEx	Whole Blood	0.1910	0.0400	3.2e-09	0.209	NA	0.176	NA	0.202	4.7e-19	NA	5.0e-16	NA	2.3e-18
7	NTR	Blood	0.1492	0.0246	0.0e+00	0.141	0.123	0.139	0.142	0.140	4.3e-43	1.4e-37	1.4e-42	1.3e-43	7.1e-43
8	TCGA	Breast Invasive Carcinoma	0.0321	0.0177	3.3e-04	0.021	0.018	0.012	NA	0.016	2.8e-05	9.2e-05	1.2e-03	NA	2.5e-04
9	TCGA	Lung Adenocarcinoma	0.0510	0.0301	2.9e-03	0.011	0.010	0.000	NA	0.004	1.8e-02	2.2e-02	3.5e-01	NA	9.6e-02
10	TCGA	Prostate Adenocarcinoma	0.0381	0.0184	3.4e-04	0.025	0.042	0.025	NA	0.031	1.2e-03	2.8e-05	1.0e-03	NA	3.3e-04
11	TCGA	Thyroid Carcinoma	0.1310	0.0490	6.1e-08	0.019	0.089	0.080	NA	0.057	5.6e-03	5.8e-09	3.3e-08	NA	3.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	2.0	3.2	7.3	2.4	0.9	2.2	1.6	0.5	-2.3	-2.2	2.7	1.5	0.9	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.2	0.4	0.3	1.1	0.4	1.0	-0.2	0.1	0.9	1.0	0.3	0.9
Depressed Affect (Nagel 2018)	1.1	2.3	4.7	-2.1	-1.4	-1.7	-0.9	-0.6	2.1	2.2	-1.4	-0.9	-0.3	1.7
Depression (Nagel 2018)	0.2	0.3	1.0	0.2	-0.3	0.8	1.0	-0.0	-0.3	-0.1	0.5	0.1	0.9	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.6	-0.9	-0.4	0.3	0.3	-0.5	0.7	0.8	-0.2	1.1	0.6	1.2
Neuroticism (Nagel 2018)	0.7	1.6	3.4	-1.8	-1.0	-1.3	-0.6	-0.9	1.6	1.6	-1.1	-0.7	-0.2	1.8
Schizophrenia (2018)	0.6	1.3	3.9	-1.5	-0.3	-0.4	-0.8	0.9	1.6	2.0	-1.0	0.1	-0.4	1.5
Schizophrenia vs Biploar Disorder	3.2	4.2	9.4	-3.1	-0.7	-1.9	-1.2	1.3	3.0	2.9	-1.8	0.4	0.5	2.9
Worry (Nagel 2018)	0.4	0.7	2.1	-1.4	-1.0	-0.3	0.1	-0.3	1.0	1.2	-0.6	-0.5	0.2	1.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.4	-0.9	-1.3	-1.2	-0.5	0.6	0.4	-0.8	-0.9	-0.5	-0.5
Alzheimer’s Disease (in father)	0.5	0.6	1.9	0.7	-0.5	1.4	0.6	0.9	-0.7	-0.8	0.3	-0.2	0.1	-1.1
Alzheimer’s Disease (including proxy)	0.5	0.8	2.1	-0.4	-1.1	-0.4	-0.7	0.3	0.6	0.4	-1.4	-1.4	-0.3	-1.3
Crohns Disease (2017)	0.6	1.4	4.3	-1.2	0.6	-2.1	-1.2	-1.4	1.3	1.1	-0.5	0.3	-0.9	1.0
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	-0.5	1.2	-0.8	-0.5	-1.1	0.7	0.7	-0.1	0.7	-0.3	1.1
Ulcerative Colitis (UC)	0.3	0.6	2.1	-0.1	1.4	0.6	0.2	-0.2	0.3	0.4	0.3	1.2	0.6	1.4
Major Depression (MDD)	0.3	0.3	0.5	0.7	0.6	0.7	-0.5	-0.3	-0.6	-0.6	0.7	-0.3	-0.5	-0.4
Reaction Time	0.7	1.3	3.7	-1.2	-1.9	-1.0	-1.3	-1.0	1.4	1.2	-0.2	-0.2	-0.3	1.1
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.4	-0.4	0.2	0.6	0.5	-0.3	0.2	0.0	-0.1	0.4	0.2	0.6
Breast Cancer	0.3	0.8	1.6	1.1	0.0	0.7	1.1	-0.4	-1.2	-1.2	1.1	0.6	0.6	-0.7
Ovarian Cancer	0.8	1.1	4.1	-0.9	-0.5	-1.0	-0.4	-2.0	0.6	0.5	-0.7	-1.0	-1.1	1.5
Prostate Cancer	0.2	0.3	0.6	0.8	-0.4	-0.1	-0.4	0.3	-0.6	-0.7	0.4	-0.4	-0.6	-0.7
Age at First Birth	0.3	0.4	1.2	-0.5	-1.1	-0.7	-0.1	-0.4	0.4	0.4	0.4	0.7	0.6	0.9
Bipolar Disorder (2011)	2.2	2.1	4.8	1.5	0.4	1.7	1.2	0.8	-1.5	-1.5	2.1	2.2	1.4	0.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.5	0.2	0.3	0.4	0.2	-0.7	-0.7	0.3	0.7	0.3	-0.6
Coronary Artery Disease (CAD)	1.0	1.2	5.2	0.3	-1.0	2.3	-0.3	1.9	-0.4	-0.3	1.1	1.0	0.7	-0.2
Crohns Disease (2012)	0.2	0.4	2.4	-0.3	-0.1	-1.6	-0.6	-0.8	0.3	0.1	-0.1	0.4	0.1	0.1
Mean Putamen Volume	1.8	2.1	4.4	1.6	2.1	1.8	1.6	1.0	-1.7	-1.9	1.6	0.2	0.1	-0.1
Fasting Glucose	0.5	0.6	2.6	1.0	1.6	-0.2	0.7	-0.4	-1.0	-0.8	-0.1	-0.0	-0.2	-0.6
HbA1C	0.4	0.5	1.1	0.9	-0.6	0.3	-0.1	-0.2	-1.1	-1.0	1.0	0.4	-0.0	-0.8
HDL Cholesterol	0.3	0.5	1.4	-1.0	0.0	-0.2	-0.8	1.1	1.2	0.9	-0.8	0.0	0.1	-0.2
LDL Cholesterol	0.6	0.9	2.8	0.7	-0.1	0.0	1.6	0.7	-0.8	-0.3	0.7	1.4	1.7	0.8
Lupus	0.1	0.2	0.7	-0.1	0.1	-0.4	0.8	0.5	-0.0	0.2	0.3	0.3	0.7	0.7
Neuroticism (2016)	0.8	1.1	4.3	-0.0	-0.0	-0.8	-0.4	-1.4	0.0	0.0	-1.4	-2.1	-1.7	-0.5
Primary Biliary Cirrhosis	0.9	1.3	5.7	1.0	0.4	0.2	2.3	0.4	-0.9	-0.6	0.5	0.8	2.4	0.6
Rheumatoid Arthritis	1.5	2.1	5.3	-1.6	1.0	-2.3	-0.9	-1.7	1.6	1.7	-1.1	-0.6	-0.6	1.9
Schizophrenia (2014)	0.4	0.9	3.6	0.3	0.6	1.0	1.1	1.9	-0.2	0.1	0.8	1.2	1.1	0.9
Triglycerides	0.1	0.2	0.7	0.0	-0.1	-0.8	0.6	-0.4	-0.1	0.0	-0.0	0.4	0.7	0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.6	0.5	-0.3	-1.1	0.2	-1.2	-0.4	-0.6	0.0	-0.2	0.4	-0.8
Ulcerative Colitis	1.4	2.0	4.9	1.0	0.8	1.6	1.8	0.5	-1.0	-1.0	1.6	2.2	2.1	0.7
Blood Eosinophil Count	0.3	2.0	5.3	-1.4	-2.3	-0.2	-1.7	0.3	1.6	1.6	0.2	1.2	1.2	2.0
Blood Platelet Count	0.2	2.1	11.2	-1.2	-1.3	-3.3	-0.8	-0.1	1.4	1.5	-0.8	-0.3	0.8	1.6
Blood Red Count	0.0	0.3	1.5	0.2	1.2	1.2	0.1	0.1	-0.3	-0.5	-0.0	0.1	-0.3	-0.2
Blood White Count	0.1	1.1	3.4	-0.9	-1.8	0.2	-0.3	-0.2	1.1	1.2	-0.2	1.0	0.9	1.9
Heel T-Score	0.1	0.7	2.4	0.9	-0.2	0.9	0.5	0.9	-1.1	-1.0	0.3	-0.6	0.1	-1.6
BMI	0.3	1.7	4.5	-1.5	0.4	-2.1	-1.0	-0.2	1.6	1.6	-1.6	-0.1	0.4	1.8
Height	0.2	4.3	18.1	-0.3	0.1	-2.1	-1.9	-4.3	0.2	0.4	-1.6	-1.9	-3.7	-1.1
Waist Hip Ratio (WHR)	0.1	0.6	1.2	-0.8	-0.9	1.0	-1.1	0.0	1.0	1.0	-0.6	0.6	-0.3	-0.1
Systolic Blood Pressure	0.4	2.2	11.0	-0.4	-0.8	1.3	-1.0	0.6	0.5	0.2	-2.2	-3.3	-1.8	-1.2
Smoking Status	1.3	3.1	9.7	0.1	-0.9	-0.4	1.5	-0.4	-0.1	0.2	2.1	3.1	2.8	2.8
Allergy or Eczema	2.5	6.5	18.2	-3.6	-1.1	-2.5	-1.3	-2.1	3.4	3.5	-1.5	0.4	0.2	4.3
Cardiovascular Disease	0.4	1.2	3.4	-0.8	-0.2	-0.3	-1.1	-0.9	1.1	1.1	-1.8	-1.9	-1.4	0.1
Hypothyroidism (self reported)	3.7	8.4	15.4	-3.8	0.3	-3.2	-3.5	-0.6	3.9	3.9	-3.3	-2.2	-2.0	2.2
Respiratory disease	0.6	1.3	2.4	-1.3	-1.4	-0.5	-0.5	-1.6	1.3	1.6	-0.7	-0.7	-0.7	1.4
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.3	-1.5	-2.1	-0.8	-0.6	1.1	1.6	1.7	-0.5	1.6	2.0	1.2
Lung FEV1/FVC ratio	0.1	0.7	3.1	-0.9	-0.5	-0.5	0.6	0.4	0.9	0.9	-0.7	-0.1	1.8	1.0
Lung FVC	0.5	2.6	5.5	1.2	-0.1	1.6	1.8	2.2	-1.2	-0.7	2.3	1.9	2.2	0.7
Neuroticism	0.4	1.1	3.4	-1.3	-1.9	-0.8	-0.2	-0.8	1.0	1.2	-0.6	-0.6	0.1	1.4
Chronotype (morning person)	0.4	1.0	2.3	-1.2	-1.5	-0.4	-1.3	0.6	1.3	1.2	-1.3	0.1	0.4	0.2
Hair Pigment	0.5	13.3	27.5	-5.1	0.2	-3.8	-2.8	-1.6	5.2	5.2	-4.6	-1.4	-1.5	4.0
Tanning	0.1	0.7	1.8	1.2	0.2	1.1	0.2	0.4	-1.3	-1.3	1.0	-0.6	-0.4	-0.3
Hand grip strength (left)	0.4	1.0	2.4	1.0	1.5	1.1	0.3	-0.5	-1.0	-1.0	1.6	1.2	-0.5	-0.0
Number of treatments/medications taken	3.0	5.5	10.2	-3.1	-2.9	-1.7	-2.6	-1.4	3.1	3.2	-2.4	-1.2	-0.9	1.7
Average weekly spirits intake	1.2	1.5	3.9	1.4	2.0	0.3	1.4	-0.1	-1.4	-1.3	1.0	1.6	0.9	-0.0
Sensitivity / hurt feelings	0.9	1.6	4.9	0.2	-0.9	-0.6	-1.4	-2.0	-0.1	-0.2	-0.9	-1.7	-2.2	-1.5
Frequency of depressed mood in last 2 weeks	1.9	2.7	7.1	-1.7	-1.1	-1.2	-1.2	-0.9	1.8	2.0	-2.7	-2.3	-1.3	0.1
Hearing difficulty/problems: Yes	1.1	1.7	3.3	-1.7	-0.8	-1.8	-1.5	-0.6	1.8	1.8	-0.7	0.5	0.3	1.7
Relative age of first facial hair	0.2	0.4	0.9	-0.2	-0.0	0.3	0.3	0.8	0.2	0.3	1.0	0.9	0.6	1.0
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	5.8	-2.1	-2.4	-1.6	-1.6	0.3	2.1	2.4	-0.9	-0.3	-0.1	1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	-1.0	-0.6	1.4	0.4	1.6	0.8	0.8	-0.3	0.3	0.7	0.6
Ever had hysterectomy (womb removed)	1.1	1.3	3.1	-1.5	0.2	-0.6	-1.6	-0.0	1.8	1.6	-1.0	-0.8	-0.9	0.9
Systolic blood pressure, automated reading	0.2	0.6	1.8	-0.9	-0.6	0.6	-0.7	0.3	0.8	0.7	-1.4	-1.1	-0.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	3.0	0.2	-0.7	-0.3	-0.6	0.5	0.0	-0.0	-0.4	-0.3	0.1	-1.7
Angina	0.3	0.3	1.0	0.6	0.4	-0.9	-0.9	-1.0	-0.2	-0.3	0.0	-0.1	-0.0	-0.7
Medication for hormone replacement therapy	0.5	0.6	1.6	-1.1	-1.0	0.3	0.0	0.3	0.9	0.7	0.2	0.5	0.9	1.3
Vitamin and mineral supplements	1.2	1.6	3.5	1.9	1.6	0.4	0.6	0.5	-1.8	-1.7	1.4	1.4	0.3	-1.0
Supplements: Zinc	0.9	1.0	2.7	-1.6	-0.7	0.7	-0.6	0.3	1.6	1.5	-1.2	-0.6	0.0	0.7
Medication: Co-codamol	0.3	0.3	1.0	-0.3	-0.9	-0.4	0.8	-0.6	0.1	0.6	-0.5	-0.1	0.3	1.0
Medication: Metformin	0.9	1.3	2.4	-1.4	-1.0	-1.3	-0.9	0.4	1.5	1.4	-0.6	0.7	1.0	1.5
Diabetes (father)	1.9	2.4	10.3	-0.7	-1.5	-3.2	-2.2	-2.3	0.8	0.7	-0.7	-0.4	-0.9	0.7
Diabetes (mother)	0.4	0.5	1.8	-0.8	0.5	-0.7	-0.6	-0.3	0.7	0.2	-1.3	-1.0	-0.6	-0.7
Severe depression (siblings)	0.9	1.0	5.4	-1.0	-0.6	-0.6	-0.2	-0.9	1.1	1.0	-0.6	0.2	0.4	2.3
Pack years adult smoking proportion	0.4	0.6	3.4	0.5	-0.1	-0.2	-0.2	-1.8	-0.4	-0.5	-0.1	-0.9	-0.8	-0.8
Impedance of leg (right)	0.2	1.2	4.3	-0.9	-1.8	-0.2	-0.9	-0.3	1.0	0.7	-1.2	-2.1	-0.9	-0.6
Leg fat-free mass (left)	0.2	1.1	3.1	-0.9	0.6	-1.8	-0.8	-1.3	1.0	1.1	-1.1	0.3	-0.3	1.6
Trunk fat percentage	1.2	4.9	12.4	-2.5	-0.9	-3.5	-2.2	-1.1	2.8	2.7	-3.1	-1.0	-0.7	1.6
Hand grip strength (right)	0.3	0.7	2.2	-0.2	1.4	-0.2	-0.9	-1.5	0.1	0.1	0.5	0.5	-1.5	0.6
Townsend deprivation index at recruitment	0.4	0.6	1.2	-0.8	-0.7	-0.7	0.3	0.9	0.7	1.1	-1.0	0.2	1.1	-0.4
Current tobacco smoking	2.1	3.4	10.8	-0.2	-1.0	0.1	1.2	-0.3	0.3	0.5	2.4	3.3	2.6	3.3
Average weekly fortified wine intake	2.0	2.4	6.7	-2.1	0.3	-0.8	-1.3	0.8	1.9	1.8	-2.6	-1.6	-1.4	-0.2
Maternal smoking around birth	0.8	1.2	2.3	1.5	1.0	0.0	1.5	-0.1	-1.5	-1.4	1.4	0.8	0.3	0.6
Fed-up feelings	2.8	5.1	7.8	-2.4	-2.0	-2.8	-1.6	-2.0	2.5	2.6	-2.8	-2.6	-1.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.7	0.5	0.8	0.3	0.6	-0.4	-0.5	-0.4	0.0	-0.3	0.1	-0.2
Relative age voice broke	1.2	1.8	4.1	1.8	1.2	2.0	1.1	1.2	-1.6	-1.5	1.7	0.3	-0.2	-0.8
Taking other prescription medications	1.6	2.5	7.0	-2.1	-2.6	-1.1	-1.6	-0.8	2.0	2.2	-1.1	-0.4	0.2	0.8
Age when periods started (menarche)	1.2	2.8	6.7	2.6	0.8	1.3	1.6	0.2	-2.5	-2.3	2.5	0.6	-0.2	-1.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-1.1	-0.5	-1.1	-0.9	-0.2	1.3	1.3	-0.6	-0.5	-0.5	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.3	0.3	0.1	1.1	1.5	0.4	-0.6	-0.4	1.0	1.2	1.1	1.2
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	4.5	-1.6	-1.3	-1.7	-1.8	-0.1	1.8	1.9	-1.6	-2.1	-1.3	0.9
Qualifications: CSEs or equivalent	0.7	0.9	1.9	-1.1	0.2	-0.2	-1.4	-0.0	1.1	0.6	-1.2	-1.4	-1.2	0.6
Serious illness, injury or assault to yourself	0.9	1.1	3.4	-0.4	-1.4	-1.9	-0.6	-1.5	0.4	0.9	-0.6	-1.4	-1.0	0.1
High blood pressure	0.2	0.7	1.8	-0.7	-1.1	-0.5	-0.7	-0.6	0.7	0.8	-1.4	-1.2	-0.6	-0.3
Hayfever, allergic rhinitis or eczema	1.9	4.1	13.7	-3.0	-1.4	-1.1	-0.8	-1.1	2.7	2.8	-1.3	-0.0	0.6	3.7
Multivitamins +/- minerals	0.4	0.5	1.9	-0.7	-0.2	-0.2	0.2	-0.4	0.8	0.6	-1.1	-1.4	-0.4	0.8
Stomach or abdominal pain in last month	3.5	4.4	10.6	-2.0	-3.2	-1.8	-2.5	-1.2	2.0	2.3	-2.1	-2.4	-1.7	-0.1
Supplements: Glucosamine	0.3	0.4	1.1	-1.1	-0.3	-0.3	-0.4	-0.3	0.8	0.9	-0.8	-0.5	-0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	3.0	0.1	-0.7	-0.5	-0.8	-1.7	-0.1	0.1	0.3	0.1	-0.3	0.2
Medication: Atenolol	0.7	0.9	3.8	0.6	0.3	0.4	-1.0	-0.3	-0.2	-0.3	-0.8	-1.2	-1.3	-1.9
Medication: Levothyroxine sodium	3.4	5.8	10.4	-3.0	-0.3	-3.1	-3.1	-0.2	3.2	3.2	-2.8	-1.8	-1.3	1.3
Sitting height	0.1	1.0	4.0	-0.4	0.9	-0.4	-0.5	-2.0	0.5	0.5	-0.8	-0.9	-1.7	0.9
Chronic bronchitis/emphysema (father)	2.5	2.9	6.8	-2.6	0.1	-2.1	-1.1	-1.0	2.5	2.4	-1.7	-0.9	-0.3	1.8
High blood pressure (mother)	0.2	0.3	1.0	-0.8	0.2	-0.1	-1.0	0.1	0.7	0.6	-0.3	-0.3	-0.2	0.6
Body mass index (BMI)	0.4	1.8	4.6	-1.6	-0.3	-2.1	-1.3	-0.5	1.7	1.6	-1.9	-0.2	0.1	1.4
Impedance of leg (left)	0.1	0.6	2.9	-0.3	-1.4	0.0	-0.4	-0.4	0.3	0.2	-0.5	-1.7	-0.7	-0.9
Leg predicted mass (left)	0.2	1.2	3.4	-0.9	0.6	-1.9	-0.9	-1.4	1.1	1.1	-1.1	0.3	-0.4	1.6
Trunk fat mass	1.3	5.4	13.9	-2.5	-0.6	-3.7	-2.3	-1.7	2.8	2.7	-3.3	-1.2	-1.0	1.6
Waist circumference	0.8	2.8	7.8	-1.9	-0.1	-2.8	-1.5	-1.0	2.1	2.0	-2.2	-0.1	-0.2	1.6
Number of incorrect matches in round	0.2	0.3	1.4	-0.5	-1.2	-0.7	-0.3	0.1	0.7	0.6	-0.0	-0.4	-0.0	0.6
Past tobacco smoking	1.8	3.4	12.7	0.5	0.1	0.7	-2.0	-1.0	-0.3	-0.7	-1.2	-3.2	-3.6	-2.5
Alcohol usually taken with meals	0.3	0.5	1.7	-0.4	0.6	-0.1	-0.3	-1.1	0.3	0.5	-0.3	-1.1	-1.3	0.4
Nervous feelings	1.7	3.3	6.4	-2.5	-0.6	-1.5	-1.8	-1.0	2.4	2.0	-2.4	-2.1	-1.4	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.5	-1.2	-1.1	-1.0	-0.6	-0.9	1.2	1.5	-1.9	-1.7	-1.0	0.6
Hearing difficulty/problems with background noise	2.2	3.6	8.0	-2.8	-2.4	-1.4	-2.5	-0.7	2.5	2.3	-1.9	-0.6	-0.1	1.1
Hair/balding pattern: Pattern 2	1.7	2.2	10.3	-1.4	-0.0	-1.4	0.1	0.5	1.4	1.4	0.3	1.6	1.8	3.2
Had menopause	0.5	0.7	3.0	-0.7	1.7	0.3	-0.4	0.6	0.8	0.7	-0.6	1.2	-0.0	0.5
Had other major operations	0.5	0.6	1.7	-0.4	0.7	-0.9	0.0	-0.7	0.3	0.4	0.7	1.3	0.1	1.3
Forced vital capacity (FVC)	0.1	0.6	1.6	0.6	-0.4	1.1	1.0	0.5	-0.6	-0.4	1.3	0.6	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.4	-0.6	1.2	0.0	0.6	0.4	0.5	0.5	0.1	0.8	0.6	1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	5.3	-1.1	-2.3	-0.5	-0.9	-0.5	1.1	1.2	-1.1	-0.4	-0.3	0.2
Qualifications: None of the above	0.4	0.8	3.7	-0.1	-0.4	1.0	0.7	1.9	0.2	0.1	0.3	1.5	1.2	-0.0
Financial difficulties in last 2 years	0.6	0.8	2.5	-0.5	-1.1	-0.9	0.7	-0.9	0.6	1.0	-0.3	0.4	1.1	1.6
Mouth/teeth dental problems	0.0	0.0	0.1	0.1	0.1	0.2	0.2	-0.2	-0.1	-0.2	0.3	0.1	-0.0	0.1
Heart attack	1.7	2.1	7.7	1.5	-0.0	-0.8	-1.1	-2.0	-1.4	-1.5	0.3	-1.1	-1.4	-2.8
Allergy	1.3	2.9	6.5	2.4	1.9	0.9	0.5	1.0	-2.2	-2.4	1.8	0.8	-0.3	-2.5
Pain all over the body in last month	0.9	0.9	2.1	-0.3	0.8	-1.2	-1.2	-1.4	0.6	0.5	-0.9	-1.1	-1.4	-0.2
Diabetes (self-reported)	1.0	1.5	4.0	-1.1	-0.8	-0.4	-0.1	2.0	1.2	1.2	-0.3	1.5	2.0	1.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.9	-2.1	-1.5	-0.3	-0.8	-0.5	2.0	1.9	-2.2	-1.1	-0.2	1.4
Medication: Ramipril	0.8	1.0	2.6	-0.9	-0.9	-1.6	-1.1	-0.1	1.1	1.2	-1.3	-0.8	-0.2	0.6
Medication: Simvastatin	0.2	0.2	1.2	-0.3	-0.1	0.4	0.0	1.1	0.4	0.8	-0.4	-0.1	0.4	0.3
Fluid intelligence score	0.1	0.3	0.7	-0.7	-0.3	0.8	-0.1	-0.4	0.5	0.3	-0.6	0.2	0.2	0.8
Illnesses of siblings	0.6	0.9	3.4	1.4	0.3	0.6	-0.0	0.4	-1.2	-1.3	0.4	0.3	-0.6	-1.9
Neuroticism score	0.4	0.9	2.0	-1.0	-1.4	-1.0	0.3	-0.9	0.8	1.0	-0.7	-1.0	0.1	1.2
Weight	0.5	2.6	6.9	-1.6	0.2	-2.6	-1.5	-1.8	1.7	1.7	-2.1	-0.5	-0.8	1.6
Impedance of arm (right)	0.1	0.3	1.7	0.5	-0.0	0.1	0.4	0.4	-0.4	-0.4	-0.3	-0.8	-0.5	-1.3
Arm fat percentage (right)	0.9	3.5	8.9	-2.2	-0.5	-3.0	-1.6	-0.5	2.3	2.2	-2.9	-0.8	-0.1	1.5
Trunk fat-free mass	0.3	1.8	6.9	-1.0	0.5	-1.7	-1.1	-2.6	1.0	1.0	-1.2	-0.5	-1.2	1.5
Hip circumference	0.4	1.8	6.6	-1.5	0.3	-2.6	-0.9	-0.4	1.5	1.5	-1.3	0.2	0.2	2.0
Time employed in main current job	0.4	0.4	1.0	-0.5	-0.3	-0.3	-0.9	-0.6	0.8	0.7	-1.0	-0.5	-0.8	0.2
Alcohol intake versus 10 years previously	0.2	0.4	0.9	-0.7	-0.3	-1.0	-0.6	-0.3	0.8	0.7	-0.9	0.1	-0.0	0.1
Father’s age at death	0.9	1.3	3.0	1.2	1.4	0.2	1.1	-0.0	-1.4	-1.3	1.7	1.4	0.7	0.2
Worrier / anxious feelings	1.0	1.9	5.7	-0.1	0.5	0.9	2.2	0.9	-0.2	-0.0	1.2	1.8	2.4	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	6.5	-1.2	-0.4	-0.9	0.2	-0.3	1.5	1.7	-0.8	0.4	0.6	2.5
Falls in the last year	0.2	0.2	0.7	-0.2	0.2	-0.4	0.0	0.6	0.1	0.6	0.7	0.6	0.4	0.8
Hair/balding pattern: Pattern 3	1.2	1.8	3.1	1.4	1.8	0.9	1.2	1.6	-1.5	-1.3	1.6	1.2	0.8	-0.9
Number of live births	1.2	1.7	3.8	1.6	1.9	-0.1	1.1	1.6	-1.4	-1.3	0.6	1.1	1.0	-1.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.8	0.8	-0.6	1.4	1.1	0.9	-0.8	-0.7	1.2	0.3	0.8	0.1
Pulse rate	0.9	1.6	5.4	0.2	-0.4	-0.4	1.6	0.1	-0.3	-0.4	1.5	2.0	2.3	1.7
Happiness	2.5	3.0	6.1	-1.5	1.1	-2.5	-1.2	-2.3	1.6	1.2	-1.8	-2.1	-1.9	1.4
Noisy workplace	1.0	1.2	2.5	-1.1	-1.2	-1.6	-0.9	-1.6	1.1	1.1	-0.5	-0.2	-0.6	1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.0	1.2	0.7	0.1	1.0	-1.4	-1.2	-0.8	1.0	-1.1	-1.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.6	-0.2	-0.3	0.6	0.3	-0.6	-0.4	0.7	0.1	0.7	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	-0.3	0.4	-0.1	-0.2	0.1	0.4	0.4	-0.6	0.3	0.1	-0.0
Asthma	0.4	0.8	2.1	-1.0	-1.2	-0.4	-0.2	-1.2	0.9	1.1	-0.7	-0.5	-0.2	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.3	-0.9	-0.7	-0.8	-1.1	-0.7	0.9	1.1	-1.2	-0.5	-0.8	-0.1
Medication: Cholesterol lowering	0.6	1.0	2.4	-1.1	-1.0	-1.1	-1.1	-0.6	1.3	1.5	-1.1	-0.4	-0.4	0.7
Depression (self-reported)	0.4	0.5	1.8	-0.8	-0.9	-0.5	-0.5	-0.2	0.7	0.8	-1.3	-0.7	0.0	-0.0
Medication: Lansoprazole	1.1	1.3	3.5	0.3	-0.3	-1.7	-0.4	-1.7	-0.2	-0.1	-1.2	-1.9	-1.3	-1.0
Prospective memory result	0.6	0.7	1.9	1.4	-0.7	0.4	0.5	0.4	-1.1	-1.1	0.4	-0.7	-0.2	-1.2
Lung cancer (father)	0.5	0.6	3.6	-0.6	-1.9	-0.4	-0.1	1.1	0.4	0.6	0.1	-0.1	0.8	0.3
Illnesses of mother	1.6	2.0	4.7	2.1	0.7	0.3	1.0	-0.7	-2.1	-2.1	0.6	-0.6	-0.8	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	5.4	1.5	-0.1	2.1	2.1	1.5	-1.6	-1.5	2.3	1.3	1.8	0.4
Pulse wave Arterial Stiffness index	1.2	1.4	4.0	-1.8	0.6	-0.7	-0.2	0.3	1.7	1.8	-0.8	0.6	0.7	2.0
Impedance of arm (left)	0.0	0.1	0.6	0.3	-0.2	-0.0	0.3	0.0	-0.2	-0.2	-0.3	-0.6	-0.5	-0.8
Arm fat mass (right)	0.9	3.7	9.6	-2.2	-0.2	-3.1	-1.8	-1.2	2.3	2.2	-2.7	-0.8	-0.5	1.8
Trunk predicted mass	0.3	1.8	6.8	-1.1	0.5	-1.7	-1.1	-2.6	1.1	1.1	-1.1	-0.4	-1.1	1.6
Standing height	0.2	1.8	9.5	-0.3	0.9	-1.4	-0.7	-3.1	0.3	0.5	-0.8	-1.0	-2.3	0.6
Length of working week for main job	1.0	1.1	2.9	-0.2	-1.2	-1.7	-1.6	-1.0	0.5	0.7	-0.8	-0.9	-1.4	-0.2
Exposure to tobacco smoke at home	0.7	0.8	5.1	0.5	0.1	-2.2	0.2	-1.2	-0.3	-0.2	0.1	-0.3	0.8	0.8
Breastfed as a baby	0.3	0.4	1.1	-0.5	0.4	0.9	0.2	1.0	0.4	0.5	-0.3	1.0	0.3	-0.2
Tense / ‘highly strung’	0.3	0.5	2.2	-0.1	-0.7	-0.2	0.8	-1.5	-0.3	0.2	-0.6	-1.0	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	5.0	-1.9	-0.8	-2.2	-0.9	-1.3	1.7	1.9	-1.4	-0.8	-0.3	1.5
Hair/balding pattern: Pattern 4	1.0	2.3	6.2	1.7	1.0	0.4	0.3	-2.1	-1.8	-2.1	-0.2	-0.8	-1.6	-2.5
Birth weight of first child	0.4	0.7	2.5	-1.1	-0.4	0.7	-0.0	0.6	1.1	1.2	-1.6	-0.5	-0.2	0.4
Peak expiratory flow (PEF)	0.5	1.1	2.0	1.3	-0.0	1.3	0.9	0.7	-1.2	-1.3	0.7	-1.2	-0.1	-1.4
Pulse wave reflection index	0.9	1.2	5.8	-1.0	2.4	-0.2	0.3	1.6	0.8	0.8	-0.9	0.0	0.3	1.0
Ever highly irritable/argumentative for 2 days	2.2	2.7	6.3	-1.6	-1.9	-2.5	-1.0	-1.0	1.7	1.9	-1.9	-1.1	0.1	1.8
Loud music exposure frequency	0.2	0.2	0.6	0.4	-0.2	0.4	0.6	0.7	-0.3	-0.2	0.1	0.5	0.8	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	0.6	1.0	0.0	0.9	-0.6	-0.7	-0.3	0.6	-0.5	0.1	0.6
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.0	1.3	1.1	0.4	1.4	0.7	-1.3	-1.2	0.9	0.4	0.8	-0.4
Blood clot in the leg (DVT)	0.7	0.9	3.7	0.7	-0.2	0.3	-0.1	-0.2	-0.9	-0.9	-0.7	-1.5	-0.9	-1.9
Medication: Paracetamol	0.6	1.0	1.7	-1.2	-1.3	-0.9	-0.7	-0.7	1.3	1.3	-1.0	-1.0	-0.5	0.4
Headache pain in last month	2.9	4.9	9.9	-1.9	-0.6	-2.7	-1.7	-2.9	1.9	1.9	-3.1	-3.1	-2.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.1	1.0	0.7	0.6	0.6	-0.7	-1.1	-1.4	1.4	0.4	0.1	0.2
Glaucoma (self-reported)	0.4	0.5	2.7	0.1	1.6	0.1	0.5	1.2	-0.2	-0.1	0.3	0.3	0.4	1.0
Gout (self-reported)	1.2	1.6	6.6	-1.4	-0.2	-0.6	-0.3	0.5	1.3	1.3	0.1	1.9	1.1	2.6
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	12.8	-3.5	-0.8	-2.5	-3.2	0.1	3.5	3.6	-2.5	-1.4	-1.1	1.9
Medication: Amlodipine	0.6	0.8	4.5	0.2	-2.1	-0.1	0.1	-0.3	-0.4	-0.2	-0.5	-1.7	-0.2	-1.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.3	0.5	0.2	0.5	-0.4	-0.3	-0.2	0.8	-0.5	-0.4	0.6
Birth weight	1.3	2.9	6.8	-1.3	-0.7	-0.9	-2.1	-1.4	1.4	1.1	-2.6	-2.3	-2.6	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	-0.0	-1.3	0.0	0.3	1.1	0.2	0.4	0.6	1.0	1.3	0.7
High blood pressure (siblings)	0.5	0.7	2.6	-1.0	0.5	-0.6	-0.4	-0.6	0.8	0.8	-0.4	-1.0	-0.6	1.6
Forced vital capacity (FVC), Best measure	0.9	3.3	7.3	2.0	0.5	2.2	2.5	1.0	-2.1	-1.9	2.7	1.4	1.5	0.4
Body fat percentage	1.2	4.7	11.7	-2.5	-1.0	-3.4	-2.1	-0.9	2.7	2.6	-3.1	-1.0	-0.5	1.5
Leg fat percentage (right)	1.2	4.2	9.4	-2.6	-1.1	-2.7	-1.9	-0.5	2.7	2.6	-3.1	-1.0	0.1	1.5
Arm fat-free mass (right)	0.4	1.9	6.2	-1.1	0.3	-1.9	-1.2	-2.5	1.1	1.1	-1.1	-0.5	-1.0	1.9
Exposure to tobacco smoke outside home	0.6	0.9	3.0	-0.5	0.5	-1.1	-0.3	-1.7	0.5	0.7	-0.6	-1.1	-0.8	1.3
Comparative body size at age 10	0.5	1.3	3.8	-0.8	-0.5	-0.7	-1.3	-1.0	0.9	0.6	-2.0	-1.7	-1.2	-0.6
Number of full brothers	0.2	0.2	0.7	-0.4	-0.5	-0.9	-0.6	-0.6	0.6	0.2	-0.1	-0.6	0.3	-0.1
Worry too long after embarrassment	0.8	1.3	4.0	1.2	0.1	1.2	1.2	-1.3	-1.4	-1.3	2.0	0.8	0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	4.7	-2.2	-0.2	-1.2	-0.7	-1.1	1.9	2.0	-1.0	0.4	0.0	2.1
Wheeze or whistling in the chest in last year	0.3	0.5	2.2	-0.3	-0.4	0.3	1.1	-0.3	0.2	0.3	0.3	0.4	1.0	1.5
Number of children fathered	0.5	0.6	1.2	-1.0	0.4	-0.3	-0.6	-0.9	0.8	0.8	-0.4	1.1	-0.3	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.6	1.9	1.7	1.2	1.0	0.7	-1.6	-1.6	0.7	0.8	-0.0	-1.1
Age at first live birth	0.4	0.7	2.7	0.1	0.9	-0.8	-0.3	-0.4	-0.4	-0.4	-0.5	-1.6	-1.3	-0.8
Pulse wave peak to peak time	1.2	1.4	4.3	1.7	-0.4	0.5	0.1	-0.6	-1.6	-1.7	0.6	-0.7	-1.0	-2.1
Health satisfaction	1.4	1.8	5.3	-0.7	-0.4	-2.1	-1.3	-1.6	1.1	1.0	-1.2	-2.3	-1.4	0.4
Shortness of breath walking on level ground	0.3	0.4	1.4	-0.5	-0.8	-0.3	0.9	-0.2	0.3	0.5	-0.5	-0.1	0.8	1.2
Qualifications: College or University degree	0.1	0.2	0.7	0.4	0.4	0.6	0.8	-0.6	-0.6	-0.2	-0.1	-0.5	-0.1	0.0
Eye problems/disorders: None of the above	0.3	0.4	1.1	0.1	-0.9	0.3	1.1	-0.7	-0.4	-0.2	0.4	0.4	1.0	0.6
Mouth/teeth dental problems: Loose teeth	2.0	2.4	8.8	1.3	-0.6	0.2	-0.4	-1.4	-1.4	-1.4	-0.2	-2.6	-1.5	-3.0
Emphysema/chronic bronchitis	0.7	0.7	2.7	0.6	0.6	0.8	1.6	-0.2	-0.7	-0.5	0.6	0.7	1.0	1.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.4	0.8	-0.5	1.0	0.7	0.8	-0.9	-0.9	1.2	0.7	0.3	0.0
Neck or shoulder pain in last month	0.9	1.2	2.4	-1.3	-1.5	-0.4	-1.3	-0.6	1.3	1.5	-1.1	-1.2	-0.7	0.0
Medication: Blood pressure	0.4	0.6	2.4	-0.1	-0.8	-0.2	-0.5	-0.1	0.1	0.2	-1.2	-1.2	-0.6	-1.6
Angina (self-reported)	0.2	0.3	1.0	0.5	0.3	-0.9	-0.8	-1.0	-0.1	-0.2	0.1	-0.1	0.1	-0.6
Migraine (self-reported)	0.8	1.0	2.2	-0.7	0.9	-0.5	-0.8	-0.9	0.9	0.8	-1.5	-1.5	-1.3	0.2
Medication: Ibuprofen	0.8	1.0	2.0	-1.1	-0.2	-1.0	-1.0	-0.9	1.1	1.3	-1.4	-0.9	-1.0	0.5
Medication: Allopurinol	1.2	1.6	5.5	-1.7	-0.3	-1.2	-0.4	0.4	1.6	1.6	-0.4	1.0	0.8	2.3
Medication: Omeprazole	0.7	0.9	4.3	-0.6	1.0	-0.6	0.1	-1.4	0.8	1.0	0.1	0.4	-0.3	2.1
Medication: Seretide 50 evohaler	0.9	1.0	5.2	-0.7	0.8	-0.6	0.3	-1.7	0.8	1.0	0.1	0.2	0.1	2.3
Mean time to correctly identify matches	0.9	1.6	4.4	-1.6	-2.0	-1.0	-2.1	-0.4	1.7	1.6	-0.4	0.1	-0.7	0.5
Heart disease (mother)	2.4	2.9	14.0	-1.9	1.8	-0.4	0.8	-0.7	1.8	1.8	0.0	1.6	0.9	3.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.6	-0.0	-0.3	-0.7	0.3	-0.8	-0.0	0.1	-0.4	-0.5	0.5	0.1
Whole body fat mass	1.2	4.8	12.4	-2.4	-0.6	-3.5	-2.3	-1.5	2.6	2.5	-3.1	-1.1	-0.9	1.5
Leg fat mass (right)	1.0	3.7	8.5	-2.2	-0.7	-2.9	-1.9	-1.1	2.4	2.2	-2.9	-0.9	-0.4	1.4
Arm predicted mass (right)	0.3	1.8	6.7	-1.0	0.2	-2.0	-1.1	-2.6	1.0	1.0	-0.9	-0.3	-0.9	1.7
Pulse rate, automated reading	0.5	1.8	7.0	-0.9	-2.6	-0.2	0.7	0.7	0.7	0.7	0.4	1.5	2.4	1.2
Alcohol intake frequency.	0.5	1.2	2.4	-1.2	0.1	-1.6	-1.3	-0.7	1.4	1.2	-1.0	-0.8	-0.7	1.0
Comparative height size at age 10	0.4	2.2	5.5	-1.5	-0.1	-1.2	-1.4	-1.7	1.7	1.6	-2.4	-1.3	-1.8	0.2
Number of full sisters	2.3	2.9	5.5	-2.3	-2.1	-0.5	-0.8	0.4	2.4	2.3	-1.0	1.4	1.3	2.3
Suffer from ‘nerves’	1.3	2.0	3.7	-1.3	0.6	-1.8	-1.5	-1.4	1.1	0.9	-1.8	-1.9	-1.9	-0.1
Overall health rating	3.5	7.5	13.9	-3.0	-2.7	-3.7	-2.8	-2.3	3.2	3.2	-3.1	-2.5	-1.0	1.2
Chest pain or discomfort	3.1	4.5	10.4	-1.5	-0.9	-2.5	-2.7	-3.2	1.9	1.8	-1.8	-2.1	-2.6	0.9
Had major operations	0.4	0.5	2.3	-0.4	1.4	-1.5	-0.3	-0.4	0.3	0.3	0.1	0.0	-0.4	0.6
Age at last live birth	0.3	0.4	1.6	0.5	1.1	-1.3	0.0	-0.3	-0.6	-0.5	-0.2	0.1	-0.2	-1.0
Family relationship satisfaction	3.0	3.7	10.1	-1.5	-0.1	-3.2	-2.0	-2.0	1.6	1.2	-2.5	-2.4	-2.0	0.2
Leg pain on walking	0.6	0.7	2.4	-1.0	-1.6	-0.5	-0.2	0.2	1.0	1.2	-0.4	0.4	0.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.1	-1.8	-0.4	-1.6	-1.5	-1.2	1.7	1.4	-1.3	-0.6	-0.2	1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	3.3	1.0	0.1	0.1	0.6	0.4	-1.1	-1.1	1.8	-0.3	0.2	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.3	0.0	1.5	0.3	-1.0	0.2	0.0	-0.4	-0.5	-0.7	-1.5	-0.9
Medication: Aspirin	0.2	0.2	0.7	-0.5	-0.7	-0.1	-0.8	0.1	0.6	0.6	-0.1	0.2	0.5	0.1
Supplements: Vitamin C	0.8	0.9	7.7	-0.6	-2.8	-0.3	-0.5	-0.8	0.5	0.7	-0.1	-0.3	0.3	0.2
Knee pain experienced in last month	0.3	0.4	1.8	0.2	-1.4	0.3	0.3	1.1	-0.2	0.1	0.3	0.5	0.8	-0.7
Hypertension (Self-reported)	0.3	1.0	2.8	-0.7	-1.1	-0.5	-0.9	-0.8	0.6	0.7	-1.5	-1.7	-0.9	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	-0.1	0.0	0.0	-0.3	-0.9	0.2	-0.0	0.6	0.7	0.2	0.9
Illnesses of father: Heart disease	0.3	0.4	0.8	0.7	0.8	0.6	0.7	-0.0	-0.9	-0.8	0.7	0.5	0.3	0.0
Illnesses of siblings: Diabetes	0.6	0.7	3.8	-0.7	0.0	-2.0	-0.1	-0.7	0.7	0.8	-0.5	-0.8	0.4	1.0
Smoking status: Previous	1.3	2.0	8.1	-0.6	-0.1	-0.4	1.6	1.4	0.3	0.7	0.3	2.1	2.8	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.2	0.3	0.2	-1.1	0.5	-1.3	-0.1	-0.2	0.3	0.1	0.3	1.5
Whole body fat-free mass	0.3	1.5	4.8	-1.0	0.6	-1.8	-1.0	-2.2	1.0	1.0	-1.0	-0.1	-0.9	1.6
Leg fat-free mass (right)	0.1	0.8	2.3	-0.5	0.9	-1.5	-0.5	-1.3	0.6	0.7	-0.7	0.4	-0.3	1.3
Arm fat percentage (left)	1.0	4.0	10.3	-2.3	-0.7	-3.2	-1.8	-0.8	2.4	2.4	-3.0	-1.0	-0.3	1.6
Average weekly red wine intake	0.1	0.1	0.4	-0.1	0.5	0.7	0.2	-0.4	-0.1	0.2	0.3	0.0	-0.4	0.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.9	-1.7	0.5	-0.6	-0.4	0.0	1.6	1.7	-0.5	0.4	0.4	1.6
Mood swings	0.6	1.1	3.5	-1.3	-1.3	-0.8	0.4	-0.3	1.2	1.4	-0.2	0.7	0.9	1.9
Loneliness, isolation	1.5	2.1	5.6	-1.7	-1.1	-1.5	-1.2	0.2	1.8	2.0	-2.4	-1.2	-0.5	0.7
Long-standing illness, disability or infirmity	0.7	1.1	6.1	-1.0	-2.5	-0.7	-0.6	0.0	0.9	1.3	-0.7	-0.6	0.6	0.3
Ever had bowel cancer screening	1.3	1.5	3.4	-1.6	-0.3	-1.6	-1.2	-0.4	1.8	1.8	-1.4	0.2	0.0	1.2
Diabetes diagnosed by doctor	1.0	1.6	3.0	-1.6	-1.7	-1.1	-0.4	0.9	1.6	1.7	-1.0	0.5	1.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	3.5	0.8	0.3	-0.4	-0.3	-1.9	-0.9	-0.7	0.4	-0.5	-0.7	-0.3
Friendships satisfaction	0.4	0.5	3.0	0.7	1.7	-0.2	0.2	-0.4	-0.7	-0.7	0.9	0.3	-0.7	-0.2
Qualifications: nursing, teaching	0.3	0.5	1.9	-0.2	-1.4	0.6	0.7	0.8	-0.0	0.3	0.6	0.5	0.8	0.6
Commuting to job workplace: Walk	1.2	1.3	3.5	-1.3	1.1	-0.9	0.2	0.3	1.5	1.4	-1.3	0.7	0.8	1.9
Eye problems/disorders: Cataract	0.4	0.5	3.6	0.5	0.8	0.7	-0.2	1.9	0.1	0.1	0.2	0.2	0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	-1.3	-1.1	-0.6	-1.1	0.0	1.2	1.1	-0.4	0.4	0.1	1.1
Medication for cholesterol	0.3	0.4	2.0	0.6	1.4	-0.3	0.1	-0.1	-0.6	-0.5	-0.2	0.2	-0.3	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	4.2	-1.9	-1.0	-0.8	-0.3	0.7	1.8	2.0	-0.8	0.8	1.4	2.1
Back pain experienced in last month	0.6	0.9	2.1	-0.6	-1.0	-0.9	-1.1	-1.4	0.5	0.5	-0.9	-1.4	-1.1	-0.5
Mineral and other dietary supplements	0.4	0.5	1.2	0.7	-0.3	-0.1	1.0	-0.4	-0.5	-0.4	1.1	0.8	1.0	0.9
Breast cancer (self-reported)	1.3	1.6	5.8	0.3	1.4	-1.1	-0.9	-1.3	-0.4	-0.5	-0.7	-2.0	-2.4	-0.8
Asthma (self-reported)	0.7	1.5	3.5	-1.6	-1.5	-0.5	-0.5	-1.1	1.5	1.7	-0.9	-0.6	-0.1	1.9
Osteoporosis (self-reported)	0.6	0.7	1.6	-1.1	-0.8	-1.1	0.1	0.1	0.9	1.1	-0.3	0.4	0.7	1.3
Osteoarthritis (self-reported)	1.4	1.9	5.3	-2.3	-0.1	-0.5	-0.8	0.1	2.1	2.0	-1.5	-1.2	-1.2	0.9
Medication: Aspirin	0.2	0.3	1.0	-0.3	-0.3	0.2	-0.4	0.6	0.4	0.5	0.4	0.9	1.0	0.3
Medication: Gliclazide	0.5	0.6	2.0	-0.7	-0.4	-1.1	-0.3	-0.3	0.6	0.6	-1.4	-1.1	0.1	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	0.8	-0.3	0.3	-0.4	-0.0	-0.5	-0.5	-0.0	-0.9	-1.2	-1.2
Smoking status: Current	2.2	3.5	12.1	-0.2	-0.8	-0.1	1.3	-0.6	0.3	0.6	2.4	3.3	2.6	3.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	6.5	1.3	-0.9	2.1	1.5	1.7	-1.4	-1.4	2.5	1.9	1.7	0.2
Whole body water mass	0.3	1.6	4.9	-1.0	0.7	-1.9	-1.0	-2.2	1.0	1.0	-1.1	-0.0	-0.8	1.7
Leg predicted mass (right)	0.1	0.7	2.4	-0.4	0.9	-1.6	-0.4	-1.3	0.5	0.6	-0.6	0.5	-0.3	1.3
Arm fat mass (left)	0.9	3.7	9.4	-2.1	-0.5	-3.1	-1.9	-1.3	2.3	2.2	-2.6	-0.9	-0.6	1.8
Number of self-reported non-cancer illnesses	2.9	5.0	12.2	-3.3	-2.3	-1.4	-1.9	-0.6	3.3	3.5	-1.9	-0.3	0.1	2.4
Average weekly champagne plus white wine intake	1.5	2.0	3.8	-1.9	0.8	-1.8	-1.4	-0.5	1.8	1.8	-1.7	-0.5	-1.0	1.4
Miserableness	0.6	1.0	2.2	-1.2	-0.8	-0.8	-0.4	-0.4	1.1	1.2	-1.5	-1.5	-0.7	-0.0
Guilty feelings	0.8	1.1	5.1	-0.6	-0.6	-2.2	0.0	-1.8	0.5	0.7	-1.1	-1.0	-0.4	0.8
Wears glasses or contact lenses	1.3	1.6	5.2	-1.2	-1.0	-1.1	-1.3	-0.4	1.1	1.1	-2.3	-1.8	-0.7	-0.6
Ever taken oral contraceptive pill	0.4	0.4	1.4	-0.0	-0.3	0.3	1.1	-0.1	-0.1	0.1	0.2	1.0	1.2	0.9
Hearing aid user	0.9	1.0	6.2	-0.6	-0.8	-0.2	-0.4	2.5	0.7	0.8	0.1	1.3	0.9	0.1
Mother’s age at death	0.5	0.6	3.1	-0.6	-0.3	1.1	0.3	1.8	0.5	0.8	0.3	0.8	0.5	0.7
Financial situation satisfaction	1.1	1.4	5.7	0.6	0.5	-1.6	0.7	-2.4	-0.8	-0.6	0.5	-2.0	-0.9	0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	0.8	-1.1	0.6	1.1	0.8	-1.0	-0.8	1.1	1.1	1.4	0.5
Commuting to job workplace: Public transport	0.6	0.8	3.6	-1.0	-1.9	-0.8	-0.4	0.5	0.8	1.0	-0.8	-0.5	0.5	0.1
Eye problems/disorders: Glaucoma	0.8	0.9	6.3	0.4	2.5	0.2	0.3	1.7	-0.3	-0.4	0.1	0.3	0.2	0.2
Medication: Blood pressure	0.2	0.3	0.9	-0.4	-0.3	-0.6	-0.8	-0.2	0.6	0.3	-0.6	-0.9	-0.7	0.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.4	-0.2	0.0	-2.3	-1.6	-1.8	0.5	0.4	-1.6	-1.9	-1.8	-0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	3.1	-0.1	0.3	1.1	-0.8	1.2	-0.1	-0.4	-0.7	-0.6	-0.5	-1.8
High cholesterol (Self-reported)	0.1	0.1	0.6	0.1	-0.0	-0.8	-0.1	-0.3	-0.2	0.1	0.0	-0.5	-0.4	-0.3
Medication: Bendroflumethiazide	0.4	0.7	2.9	-0.3	-1.2	1.7	0.6	1.4	0.0	-0.2	0.3	0.2	0.8	0.2
Medication: Paracetamol	0.7	1.1	2.3	-1.3	-0.5	-0.8	-0.4	-0.7	1.4	1.5	-0.9	-0.9	-0.7	1.4
Medication: Lisinopril	0.3	0.4	1.7	0.0	-0.2	0.1	-0.5	0.4	-0.2	-0.2	0.4	1.1	0.5	-1.3
Medication: Atorvastatin	0.4	0.5	1.1	0.9	-0.7	-0.1	0.6	-0.3	-1.0	-1.0	0.5	-0.1	-0.0	-1.0
Illnesses of father: High blood pressure	0.6	0.8	2.3	-1.2	-0.8	0.6	0.2	1.1	0.6	0.8	-0.0	0.9	1.5	1.0
Alcohol drinker status: Never	0.3	0.4	1.6	0.8	-0.1	0.0	0.3	0.2	-0.7	-0.8	0.1	-0.7	0.1	-1.3
Ever smoked	2.2	3.9	13.7	-0.4	-0.7	-0.3	2.1	1.2	0.2	0.6	1.6	3.6	3.7	2.6
Basal metabolic rate	0.3	1.9	4.9	-1.2	0.5	-2.2	-1.1	-2.2	1.2	1.2	-1.4	-0.2	-0.8	1.7
Leg fat percentage (left)	0.9	3.4	7.3	-2.3	-1.1	-2.7	-1.7	-0.5	2.4	2.3	-2.7	-0.9	0.1	1.4
Arm fat-free mass (left)	0.4	1.8	4.7	-1.3	0.2	-1.9	-1.1	-2.2	1.3	1.2	-1.2	-0.2	-0.7	1.9
Number of operations (self-reported)	1.1	1.6	5.8	-1.4	0.5	-2.4	-1.2	-0.5	1.4	1.4	-1.0	-0.5	-0.6	1.6
Average weekly beer plus cider intake	1.6	2.3	4.1	-1.9	-2.0	-1.9	-1.3	0.5	2.0	2.0	-1.6	-0.3	0.5	1.4
Irritability	3.0	5.0	10.6	-3.3	-1.6	-2.4	-1.5	-1.2	3.0	3.0	-2.3	-1.4	-0.3	2.7
Risk taking	0.7	1.0	2.5	1.5	-0.8	0.0	0.8	-0.7	-1.6	-1.3	1.3	0.8	0.3	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.6	-0.8	0.7	-1.6	-0.4	0.1	0.8	1.1	-0.1	0.5	-0.4	0.9
Fractured/broken bones in last 5 years	0.5	0.7	2.7	0.9	1.6	0.1	1.2	-0.3	-0.9	-0.6	1.0	0.4	0.1	0.4
Age started oral contraceptive pill	1.1	1.4	2.8	-1.6	-0.9	-0.0	-1.7	0.5	1.6	1.6	-1.5	0.6	-0.8	0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.6	-0.9	0.5	0.9	0.1	0.3	0.9	0.7	-1.1	0.3	0.4	1.3
Ever depressed for a whole week	0.6	0.7	3.0	0.1	0.1	-1.0	-0.7	-1.2	0.0	-0.1	-0.6	-1.2	-1.7	-0.4
Unable to work because of sickness or disability	2.0	2.6	8.1	-1.6	-2.9	-0.8	-0.6	2.1	1.7	2.1	-0.9	0.8	2.0	0.5
Commuting to job workplace: Cycle	1.2	1.4	2.5	1.3	-0.2	0.8	1.4	0.2	-1.6	-1.4	1.3	1.2	1.4	-1.2
Myopia	0.9	1.2	4.2	-1.3	0.6	-0.9	0.2	0.7	1.3	1.4	-0.3	0.9	1.2	2.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.5	0.2	0.7	0.6	0.9	0.8	-0.3	-0.4	1.2	1.2	0.8	0.8
Cholesterol lowering medication	0.6	0.9	2.2	0.9	0.3	1.4	1.5	1.1	-0.9	-0.6	1.1	0.7	1.1	0.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	4.7	-0.9	1.0	-1.0	-0.6	-1.8	1.2	1.4	-0.2	0.1	-0.7	2.2
Pain experienced in last month	1.1	1.8	3.6	0.3	1.2	1.3	1.9	1.4	-0.6	-0.6	1.3	1.8	1.8	1.6
Supplements: Calcium	0.8	0.8	2.2	-1.5	-0.9	0.3	0.5	0.9	1.0	1.3	-0.3	0.4	0.9	1.3
Basal cell carcinoma (self-reported)	0.2	0.2	1.3	0.4	-0.2	-0.3	-0.2	-1.1	-0.3	-0.3	0.2	0.0	-0.7	-0.1
Heart attack/myocardial infarction (self-reported)	1.9	2.5	8.9	1.6	-0.3	-0.8	-1.2	-2.2	-1.4	-1.5	0.1	-1.4	-1.7	-3.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.6	0.6	-0.5	0.3	0.2	-0.0	-0.8	-0.8	-0.7	-1.5	-0.7	-1.6
Heart disease (siblings)	3.2	4.0	9.5	-2.6	-1.3	-2.4	-1.2	-1.6	2.7	2.7	-0.8	-0.3	-0.1	3.1
Alcohol drinker status: Previous	0.1	0.1	0.6	0.2	-0.4	0.2	0.4	0.7	-0.2	-0.1	0.0	-0.2	0.4	0.1
Pack years of smoking	0.7	1.1	3.7	0.5	0.2	-0.5	-0.6	-1.9	-0.3	-0.4	-0.7	-1.6	-1.4	-1.4
Impedance of whole body	0.1	0.3	1.2	0.3	-0.8	0.3	0.3	0.1	-0.3	-0.3	-0.1	-1.1	-0.5	-1.1
Leg fat mass (left)	0.8	3.1	8.1	-1.9	-0.6	-2.8	-1.7	-1.1	2.1	2.0	-2.6	-0.8	-0.3	1.3
Arm predicted mass (left)	0.3	1.6	5.1	-1.0	0.4	-1.9	-0.9	-2.3	1.0	1.0	-0.9	-0.1	-0.6	1.8