Hub : Genes

TADA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.059 0.0260 6.7e-03 0.048 0.011 0.023 0.026 0.035 1.5e-06 0.01500 7.0e-04 0.00037 4.1e-05
2 GTEx Brain Cerebellar Hemisphere 0.305 0.0990 7.9e-04 0.001 NA 0.056 NA 0.023 3.0e-01 NA 1.5e-02 NA 8.4e-02
3 GTEx Brain Cerebellum 0.227 0.0840 3.5e-03 0.109 NA 0.168 NA 0.143 4.2e-04 NA 1.1e-05 NA 5.1e-05
4 GTEx Cells EBV-transformed lymphocytes 0.188 0.0620 2.4e-04 0.029 NA 0.053 NA 0.031 4.0e-02 NA 8.1e-03 NA 3.5e-02
5 GTEx Esophagus Mucosa 0.151 0.0480 7.1e-06 0.076 NA 0.062 NA 0.065 8.4e-06 NA 5.3e-05 NA 3.8e-05
6 GTEx Nerve Tibial 0.203 0.0547 2.6e-06 0.108 NA 0.115 NA 0.132 4.4e-08 NA 1.8e-08 NA 1.3e-09
7 GTEx Skin Not Sun Exposed Suprapubic 0.149 0.0500 5.3e-04 0.138 NA 0.093 NA 0.110 5.5e-08 NA 8.4e-06 NA 1.3e-06
8 GTEx Skin Sun Exposed Lower leg 0.109 0.0350 6.7e-05 0.028 NA 0.064 NA 0.043 2.2e-03 NA 5.5e-06 NA 1.8e-04
9 METSIM Adipose 0.028 0.0126 3.3e-03 0.034 0.016 0.024 0.018 0.025 5.8e-06 0.00180 1.5e-04 0.00084 1.1e-04
10 TCGA Rectum Adenocarcinoma 0.253 0.1060 4.9e-04 0.052 0.149 0.088 NA 0.072 2.3e-02 0.00024 4.4e-03 NA 9.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.4 0.6 2.5 0.8 -0.5 -0.5 0.0 0.6 -1.6 0.3 -1.0 0.1 -1.1
Bipolar Disorder or Schizophrenia 1.3 3.1 11.2 0.4 -1.3 -2.7 0.0 1.8 -3.3 -0.7 0.3 2.1 1.7
Depressed Affect (Nagel 2018) 0.3 0.6 1.3 0.1 -1.0 1.0 0.0 1.0 0.2 0.3 0.7 1.1 1.1
Depression (Nagel 2018) 1.0 1.5 5.0 1.0 -1.7 0.4 0.0 2.2 0.3 1.2 0.6 1.9 0.5
Intelligence (Savage-Jansen 2018) 0.4 1.1 3.5 0.3 1.0 -0.7 0.0 -1.0 -1.1 -1.7 -0.7 -0.3 -1.9
Neuroticism (Nagel 2018) 0.9 2.1 7.2 0.4 -1.7 0.2 0.0 1.9 -0.9 0.5 0.6 2.7 2.4
Schizophrenia (2018) 2.0 4.3 9.8 -0.2 -1.3 -3.1 0.0 1.8 -3.0 -1.1 1.1 2.6 3.0
Schizophrenia vs Biploar Disorder 0.7 1.0 3.5 -1.9 0.1 -1.2 0.0 -0.2 -1.1 -1.0 0.7 0.4 1.5
Worry (Nagel 2018) 0.7 1.4 5.2 0.4 -1.5 0.0 0.0 1.6 -1.0 0.2 0.1 2.3 1.7
Alzheimer’s Disease (in mother) 0.5 0.6 4.0 0.5 0.1 0.1 0.0 -0.4 -0.9 -0.2 0.2 0.6 -2.0
Alzheimer’s Disease (in father) 0.3 0.3 1.2 0.6 0.2 -0.5 0.0 -1.1 -0.0 -0.8 -0.7 -0.6 0.1
Alzheimer’s Disease (including proxy) 0.5 0.8 4.0 0.8 0.0 0.2 0.0 -1.5 -0.3 -0.7 -0.2 -0.6 -2.0
Crohns Disease (2017) 0.3 0.7 1.7 1.1 -0.2 1.3 0.0 -0.3 1.3 0.7 -0.1 -1.2 -0.5
Irritable Bowel Disease (IBD) 0.7 1.6 4.2 0.9 -0.9 0.6 0.0 2.0 -0.4 2.0 2.0 1.0 0.5
Ulcerative Colitis (UC) 1.9 3.5 9.5 -0.2 -1.2 -0.2 0.0 3.1 -1.3 2.6 2.9 2.4 1.2
Major Depression (MDD) 2.9 3.5 7.8 -0.3 -2.2 0.3 0.0 2.8 -0.8 2.6 2.7 2.0 1.6
Reaction Time 1.7 3.2 8.5 -1.1 2.5 -0.8 0.0 -2.9 -0.5 -2.4 -2.1 -2.0 -1.2
Verbal and Numeric Reasoning (VNR) 0.5 1.1 5.0 0.3 0.3 -0.4 0.0 -1.2 -1.0 -1.7 -0.7 -0.1 -2.2
Breast Cancer 0.2 0.4 1.2 1.1 0.6 1.1 0.0 0.3 0.5 0.2 -0.0 0.6 0.4
Ovarian Cancer 0.4 0.6 3.4 0.2 0.9 -0.2 0.0 -0.8 -0.5 -0.2 -0.5 0.5 -1.8
Prostate Cancer 0.3 0.5 1.8 1.3 -0.8 0.1 0.0 -0.2 0.4 0.3 1.3 -0.2 -0.0
Age at First Birth 0.4 0.6 2.6 -0.8 -1.6 0.2 0.0 0.2 0.5 -0.1 0.4 -0.0 1.6
Bipolar Disorder (2011) 1.4 1.4 4.7 0.6 -1.2 -0.1 0.0 2.2 -0.5 1.8 1.0 1.4 0.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.3 -0.7 -0.2 0.7 0.0 -0.5 0.9 0.4 -0.4 -0.8 -1.1
Coronary Artery Disease (CAD) 0.4 0.5 1.4 -0.3 -0.0 -1.2 0.0 -0.5 -0.0 -1.0 -0.9 -0.5 -1.0
Crohns Disease (2012) 0.9 1.4 3.5 1.5 1.4 0.9 0.0 -1.3 1.2 0.3 -0.8 -1.9 -1.3
Mean Putamen Volume 0.6 0.7 2.7 -0.0 0.8 1.1 0.0 -0.9 1.6 -0.0 -0.4 -1.2 -0.6
Fasting Glucose 0.7 0.9 1.7 -0.8 -1.0 -1.3 0.0 0.4 -1.0 1.3 1.3 0.5 0.7
HbA1C 0.7 0.7 2.7 -1.7 -0.9 1.3 0.0 0.1 1.2 0.5 0.5 0.0 -0.2
HDL Cholesterol 0.5 0.8 3.0 1.1 -0.9 -0.1 0.0 0.9 0.1 0.6 0.7 1.7 1.0
LDL Cholesterol 0.3 0.4 1.5 -1.2 0.7 0.7 0.0 0.3 0.9 0.3 -1.0 -0.2 -0.0
Lupus 0.3 0.5 1.7 1.3 -0.3 -0.5 0.0 -0.4 -0.8 -0.9 -1.0 0.2 -0.2
Neuroticism (2016) 1.2 1.7 3.8 1.5 -0.7 1.7 0.0 1.3 1.4 1.6 1.9 0.9 1.0
Primary Biliary Cirrhosis 0.6 0.9 4.2 0.6 2.1 1.2 0.0 -0.4 0.9 -0.1 0.3 -1.3 0.3
Rheumatoid Arthritis 1.4 2.0 5.4 2.2 -2.3 -0.8 0.0 1.0 -1.1 1.5 1.5 1.1 0.9
Schizophrenia (2014) 2.6 5.6 17.7 0.2 -1.3 -3.9 0.0 1.7 -4.2 -2.0 1.0 2.4 2.9
Triglycerides 0.1 0.2 0.6 -0.5 -0.4 -0.3 0.0 0.3 -0.3 0.4 0.1 0.3 -0.7
Type 2 Diabetes (T2D) (2012) 2.1 2.5 5.7 -0.5 -1.7 -1.1 0.0 2.4 -1.4 1.4 1.8 2.2 1.5
Ulcerative Colitis 1.2 1.8 4.5 0.5 -0.4 -0.4 0.0 2.1 -0.8 2.1 2.1 1.3 1.4
Blood Eosinophil Count 0.0 0.3 1.4 1.2 -0.1 -0.2 0.0 -0.4 -0.5 -0.9 -0.6 -0.7 0.3
Blood Platelet Count 0.2 1.9 4.2 1.9 -1.1 1.2 0.0 2.0 0.8 2.0 1.4 1.1 1.2
Blood Red Count 0.3 3.0 8.0 -0.1 2.6 2.8 0.0 -1.2 2.6 1.2 -0.4 -1.9 -1.3
Blood White Count 1.3 9.4 29.8 -1.2 -0.4 5.5 0.0 1.4 4.8 4.9 2.1 -0.6 2.9
Heel T-Score 0.2 1.6 4.8 1.4 1.4 -1.7 0.0 -0.3 -2.2 -0.8 -0.0 -0.2 -2.0
BMI 0.6 3.3 13.2 -0.3 -1.0 3.2 0.0 0.7 2.0 3.6 1.9 -0.2 -0.4
Height 0.1 2.2 5.4 1.6 -2.3 1.2 0.0 1.9 0.6 2.1 1.3 1.3 -1.0
Waist Hip Ratio (WHR) 0.4 1.7 3.7 1.2 -1.0 -0.3 0.0 1.8 -1.2 1.3 1.1 1.9 1.9
Systolic Blood Pressure 0.4 1.8 8.4 -2.9 0.5 -0.6 0.0 1.9 -0.6 -0.0 -1.1 1.7 0.8
Smoking Status 0.9 2.2 8.4 -0.7 1.5 2.6 0.0 -0.6 2.9 0.6 -0.4 -1.8 -0.2
Allergy or Eczema 1.2 3.0 9.9 -1.2 0.7 -2.5 0.0 -0.9 -2.1 -3.1 -2.3 -1.2 -0.3
Cardiovascular Disease 0.2 0.8 1.8 0.0 -0.7 1.0 0.0 1.3 0.3 1.4 1.1 0.9 0.7
Hypothyroidism (self reported) 0.6 1.4 3.9 -0.3 -0.9 -0.1 0.0 1.8 -1.0 1.8 2.0 1.0 0.5
Respiratory disease 0.3 0.6 2.9 0.4 -0.3 -0.7 0.0 0.9 -0.7 -0.2 0.3 0.9 1.7
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.1 -1.0 -0.2 -0.5 0.0 -0.0 -1.0 -0.0 1.0 -0.0 -0.6
Lung FEV1/FVC ratio 0.2 0.9 3.3 0.9 -0.4 -1.8 0.0 -0.2 -1.8 -0.5 -0.3 0.4 0.8
Lung FVC 0.3 1.4 4.1 -1.2 2.0 2.0 0.0 -0.2 1.9 0.5 -0.3 -0.4 0.3
Neuroticism 0.2 0.4 2.6 0.0 -0.4 0.3 0.0 0.4 0.2 -0.5 -0.2 0.5 1.6
Chronotype (morning person) 0.5 1.2 3.1 1.8 -0.2 1.4 0.0 0.9 1.6 1.5 1.1 0.3 0.1
Hair Pigment 0.0 0.7 1.8 0.7 -0.6 0.9 0.0 1.2 0.7 1.4 0.2 1.1 0.7
Tanning 0.2 2.2 6.5 -1.1 1.9 0.6 0.0 -1.8 1.2 -0.7 -0.6 -2.1 -2.5
Hand grip strength (left) 0.7 1.8 7.2 -1.1 -0.9 2.7 0.0 0.4 2.2 1.9 0.3 -0.4 -0.4
Number of treatments/medications taken 1.5 2.8 6.3 -1.1 -2.1 2.4 0.0 1.6 1.1 2.5 2.1 1.4 0.3
Average weekly spirits intake 0.5 0.7 2.6 0.6 0.1 0.9 0.0 -0.7 0.4 0.0 -0.6 -1.4 -1.6
Sensitivity / hurt feelings 1.2 2.0 9.2 1.2 -0.8 -1.7 0.0 -0.4 -0.9 -1.4 -1.7 -0.2 3.0
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.4 0.2 0.2 0.1 0.0 0.2 0.5 -0.1 -0.1 0.1 0.6
Hearing difficulty/problems: Yes 1.1 1.7 7.1 0.7 -1.3 0.4 0.0 1.5 -0.3 1.9 2.7 1.3 0.3
Relative age of first facial hair 0.3 0.7 3.8 -2.0 1.2 0.3 0.0 0.3 0.0 0.3 -0.2 0.5 1.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 4.0 -2.0 -1.1 -0.4 0.0 0.9 -0.6 0.2 0.8 1.5 -1.4
Ever used hormone-replacement therapy (HRT) 1.4 1.7 6.2 -0.3 -1.1 -2.0 0.0 1.5 -2.5 -0.3 0.2 1.6 0.9
Ever had hysterectomy (womb removed) 0.9 1.0 2.2 -1.5 0.5 1.4 0.0 -0.8 1.4 -0.2 -0.9 -1.2 -0.6
Systolic blood pressure, automated reading 0.6 1.8 10.5 -3.2 -1.2 0.4 0.0 1.8 0.3 0.8 -0.0 0.7 1.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 3.1 1.0 0.9 0.9 0.0 -0.6 0.6 0.5 0.0 -0.8 -1.8
Angina 0.2 0.3 1.3 -1.2 -0.5 0.7 0.0 -0.2 0.5 -0.2 0.1 0.0 0.6
Medication for hormone replacement therapy 1.4 1.6 9.3 -0.2 -0.3 -1.8 0.0 0.5 -3.0 -0.3 0.5 1.2 -1.1
Vitamin and mineral supplements 0.4 0.6 2.5 1.6 1.5 -0.2 0.0 0.6 -0.4 0.2 -0.3 0.4 -0.6
Supplements: Zinc 0.2 0.2 0.8 0.4 -0.7 0.4 0.0 -0.0 0.1 -0.2 -0.9 0.6 -0.6
Medication: Co-codamol 0.5 0.6 2.5 0.9 1.0 1.1 0.0 -0.0 0.6 0.4 0.1 -0.4 -1.6
Medication: Metformin 0.3 0.5 1.7 -1.3 0.8 0.3 0.0 -0.9 -0.0 -0.2 0.5 -1.0 0.4
Diabetes (father) 1.8 2.2 5.4 1.1 -0.7 2.3 0.0 0.0 2.1 1.9 2.3 -1.2 -0.7
Diabetes (mother) 0.4 0.6 1.6 0.7 -0.9 0.3 0.0 0.8 -0.3 0.9 1.0 1.3 -0.4
Severe depression (siblings) 0.6 0.7 1.7 1.2 1.2 0.1 0.0 -0.9 -0.0 -1.1 -1.3 0.3 -0.8
Pack years adult smoking proportion 0.5 0.7 2.2 0.3 1.1 1.1 0.0 -0.7 1.5 -0.3 -0.1 -0.5 -1.2
Impedance of leg (right) 0.2 0.8 2.8 -0.4 0.7 -1.5 0.0 0.2 -0.9 -1.7 -0.9 0.2 0.5
Leg fat-free mass (left) 0.3 1.8 4.7 1.5 -0.5 2.2 0.0 0.1 1.5 2.1 1.1 -0.3 -1.5
Trunk fat percentage 0.4 1.6 6.2 -0.4 -0.6 2.5 0.0 0.3 1.4 1.9 1.6 -0.3 -0.7
Hand grip strength (right) 0.5 1.5 5.2 -1.1 -0.2 2.3 0.0 -0.3 2.1 1.4 0.0 -0.8 -1.1
Townsend deprivation index at recruitment 0.7 1.0 2.2 1.2 1.0 1.0 0.0 -0.9 1.3 0.6 0.9 -1.5 0.7
Current tobacco smoking 1.1 1.8 7.8 -0.0 0.9 2.3 0.0 -0.6 2.8 0.4 -0.1 -1.8 -0.5
Average weekly fortified wine intake 1.4 1.7 5.8 0.5 1.3 -0.6 0.0 -1.5 -0.6 -1.1 -1.4 -1.5 -2.4
Maternal smoking around birth 1.2 1.8 5.2 0.7 -1.8 0.7 0.0 1.8 -0.1 2.3 1.7 1.5 0.0
Fed-up feelings 0.2 0.4 1.7 1.3 -0.6 1.0 0.0 0.3 0.8 0.2 0.2 0.5 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 3.6 1.1 -1.9 0.8 0.0 1.9 1.1 1.6 1.2 0.8 1.6
Relative age voice broke 0.4 0.6 1.4 0.1 -0.0 -0.7 0.0 0.9 -1.1 0.2 0.7 1.1 1.2
Taking other prescription medications 2.3 3.6 10.9 -1.1 -2.7 0.6 0.0 2.9 -0.9 2.2 1.4 3.3 0.1
Age when periods started (menarche) 1.5 3.6 11.8 -0.6 -3.4 0.2 0.0 2.7 -0.5 2.2 1.8 1.8 2.1
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 4.3 0.8 1.1 2.1 0.0 -0.8 1.1 -0.1 -0.1 -0.6 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 6.2 2.5 -0.2 -1.2 0.0 1.3 -1.0 0.6 0.3 1.0 -0.3
Tinnitus: Yes, but not now, but have in the past 3.9 4.2 10.0 0.2 1.7 1.4 0.0 -2.8 1.9 -1.8 -1.9 -2.9 -3.2
Qualifications: CSEs or equivalent 1.0 1.3 4.7 1.2 0.1 2.0 0.0 -0.5 2.2 0.9 -0.1 -1.3 -0.8
Serious illness, injury or assault to yourself 0.5 0.6 2.2 -1.5 -0.3 0.3 0.0 0.8 -0.3 0.2 -0.4 1.4 0.6
High blood pressure 0.3 0.9 2.2 -0.7 0.8 1.4 0.0 -0.8 1.0 -0.4 -0.4 -1.5 -1.2
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.0 -0.7 0.2 -1.6 0.0 -0.6 -1.3 -2.0 -1.4 -1.1 -0.0
Multivitamins +/- minerals 0.6 0.8 3.3 -1.4 -1.8 -1.0 0.0 -0.7 -0.2 -0.6 -0.1 -0.6 0.5
Stomach or abdominal pain in last month 2.0 2.5 9.2 1.3 0.5 2.6 0.0 -1.0 3.0 0.8 0.2 -1.3 -1.9
Supplements: Glucosamine 0.5 0.7 1.3 -1.1 -0.8 -1.1 0.0 -0.2 -1.0 -1.0 -0.4 1.1 0.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 2.2 -0.8 0.3 0.9 0.0 -0.9 1.5 -0.1 -1.0 -0.8 -1.2
Medication: Atenolol 1.3 1.6 6.3 -0.0 -0.0 2.5 0.0 0.6 1.7 1.2 0.6 1.2 -1.8
Medication: Levothyroxine sodium 0.3 0.5 3.2 -1.8 -0.2 0.3 0.0 0.6 -0.2 0.4 0.3 0.0 0.9
Sitting height 0.2 1.1 5.4 0.7 0.4 0.9 0.0 -1.0 1.2 -0.6 -0.7 -0.9 -2.3
Chronic bronchitis/emphysema (father) 0.9 1.0 2.1 -0.5 -1.5 0.5 0.0 1.2 0.3 1.5 1.1 1.0 1.3
High blood pressure (mother) 1.2 1.7 5.2 -0.7 -1.1 -0.6 0.0 2.1 -1.3 0.9 1.4 2.3 0.8
Body mass index (BMI) 0.7 2.9 10.2 0.1 -0.8 3.2 0.0 0.4 1.9 3.0 2.0 -0.5 -0.6
Impedance of leg (left) 0.1 0.3 1.1 -0.6 0.7 -0.5 0.0 0.2 -0.2 -1.0 -0.6 0.2 0.4
Leg predicted mass (left) 0.3 1.8 4.8 1.5 -0.5 2.2 0.0 0.1 1.6 2.0 1.0 -0.3 -1.6
Trunk fat mass 0.5 2.0 7.7 0.1 -0.6 2.8 0.0 0.4 1.7 2.3 1.7 -0.4 -0.9
Waist circumference 0.6 2.1 7.5 0.4 -0.3 2.7 0.0 0.5 1.7 2.7 1.4 -0.6 -0.7
Number of incorrect matches in round 0.6 1.0 4.1 -0.5 0.8 -0.8 0.0 -1.3 -0.4 -1.1 -0.5 -1.1 2.0
Past tobacco smoking 1.1 2.0 6.7 0.6 -1.6 -2.3 0.0 1.0 -2.6 -0.7 0.6 1.4 1.1
Alcohol usually taken with meals 1.5 2.4 5.1 -1.0 1.5 -1.9 0.0 -2.1 -1.4 -2.0 -2.2 -1.2 -0.4
Nervous feelings 0.7 1.3 4.0 -0.3 -1.3 -0.8 0.0 1.4 -1.2 0.4 0.5 1.6 2.0
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.3 0.6 -1.4 -0.9 0.0 0.9 -0.6 0.6 0.5 0.7 1.5
Hearing difficulty/problems with background noise 0.5 0.8 2.2 -0.3 -0.8 -0.5 0.0 0.1 -1.3 0.4 1.5 1.2 -1.0
Hair/balding pattern: Pattern 2 0.4 0.5 1.9 -0.0 0.4 0.6 0.0 1.0 0.2 0.9 1.4 0.3 0.7
Had menopause 0.7 0.9 5.7 -2.4 -0.7 -0.6 0.0 0.4 -0.9 0.2 -0.6 0.2 1.0
Had other major operations 1.1 1.4 2.7 -1.3 -1.6 1.6 0.0 0.3 1.3 1.6 0.9 -0.6 -1.2
Forced vital capacity (FVC) 0.4 1.7 4.9 -0.7 1.0 1.7 0.0 -1.2 1.9 0.3 -0.9 -1.3 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.2 1.8 0.4 -0.5 0.0 1.0 -0.5 0.6 -0.3 0.6 -1.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 4.5 0.8 -2.1 0.0 0.0 1.8 -0.3 1.2 -0.1 1.6 1.1
Qualifications: None of the above 1.0 2.2 5.8 -0.7 0.7 2.4 0.0 0.9 2.1 1.7 1.6 0.1 2.1
Financial difficulties in last 2 years 1.7 2.3 6.0 1.4 1.2 0.4 0.0 -2.4 1.1 -1.9 -1.4 -2.4 -1.2
Mouth/teeth dental problems 0.2 0.3 1.0 -0.5 -0.4 -0.8 0.0 0.1 0.1 -0.7 -1.0 0.1 -0.2
Heart attack 0.4 0.5 2.0 -1.4 -0.1 -0.7 0.0 0.0 -1.1 -0.2 -0.3 0.2 -0.9
Allergy 0.2 0.4 1.3 -0.2 0.5 0.8 0.0 0.0 0.8 1.1 0.4 0.3 -0.8
Pain all over the body in last month 1.6 1.7 6.5 2.5 0.4 1.6 0.0 1.1 1.2 1.6 1.5 0.1 0.2
Diabetes (self-reported) 0.5 0.8 2.4 -0.4 0.7 1.6 0.0 -0.5 0.7 0.8 1.2 -1.0 -0.9
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.0 -0.3 -0.1 -1.7 0.0 -0.8 -1.7 -1.6 -0.9 -0.7 -0.3
Medication: Ramipril 0.8 1.0 3.0 -1.7 0.2 1.4 0.0 -0.8 0.1 0.2 -1.4 -1.0 -1.0
Medication: Simvastatin 0.7 1.0 3.7 -0.1 -0.4 1.9 0.0 -0.9 1.8 0.5 0.2 -0.9 1.0
Fluid intelligence score 0.9 1.9 8.6 0.0 1.3 0.8 0.0 -2.2 0.1 -1.2 -0.3 -1.5 -2.9
Illnesses of siblings 0.6 0.8 6.4 2.5 0.7 -0.1 0.0 -0.4 0.4 0.1 -0.2 0.0 -0.8
Neuroticism score 0.4 0.9 4.1 0.8 -1.1 0.1 0.0 1.2 -0.0 0.0 -0.0 1.2 2.0
Weight 0.6 2.8 10.2 0.4 -1.1 2.9 0.0 0.9 1.7 3.2 1.9 -0.0 -1.1
Impedance of arm (right) 0.5 2.1 7.5 -1.0 -0.1 -2.7 0.0 0.1 -2.0 -2.5 -1.5 0.5 -0.0
Arm fat percentage (right) 0.4 1.5 5.7 0.0 -0.5 2.4 0.0 -0.1 1.3 1.9 1.3 -0.7 -1.1
Trunk fat-free mass 0.3 1.8 4.8 1.6 -0.1 2.2 0.0 0.0 1.7 2.1 0.8 -0.5 -1.5
Hip circumference 0.4 1.9 5.7 0.3 -0.7 2.4 0.0 0.5 1.8 2.3 1.4 -0.6 -1.2
Time employed in main current job 0.7 0.8 3.7 -1.9 -0.1 -0.0 0.0 1.3 -0.1 1.0 -0.1 1.1 0.9
Alcohol intake versus 10 years previously 0.4 0.6 2.3 -0.0 -1.4 0.1 0.0 0.1 -0.2 0.4 1.2 0.1 1.5
Father’s age at death 0.4 0.6 1.7 -1.3 -0.1 -0.2 0.0 -1.1 0.3 -1.3 -0.3 -0.9 0.5
Worrier / anxious feelings 1.0 2.0 5.8 1.2 -1.3 -1.2 0.0 1.6 -1.8 -0.1 0.4 2.4 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.0 0.9 -0.5 1.0 0.0 0.7 0.2 1.0 0.4 0.4 0.9
Falls in the last year 1.0 1.4 4.3 1.9 0.2 2.1 0.0 -0.4 2.1 0.2 -0.1 -0.8 -0.7
Hair/balding pattern: Pattern 3 0.3 0.5 2.1 -0.6 -0.6 -1.4 0.0 0.5 -1.2 0.2 -0.6 0.4 0.3
Number of live births 1.4 2.0 4.9 0.8 1.5 0.9 0.0 -1.5 1.8 -1.5 -1.8 -2.2 0.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 5.5 -0.3 0.7 0.9 0.0 -1.0 0.8 0.3 -1.0 -0.8 -2.3
Pulse rate 0.9 1.5 6.3 -1.1 0.4 -2.5 0.0 0.1 -2.4 -0.7 0.1 0.4 1.0
Happiness 1.0 1.2 2.9 -1.2 0.2 -1.7 0.0 0.3 -0.9 -1.3 -1.5 0.5 1.6
Noisy workplace 2.0 2.5 6.1 -0.6 -0.8 2.5 0.0 2.1 1.5 2.2 1.2 1.5 1.5
Qualifications: A levels/AS levels or equivalent 1.6 3.6 13.2 0.0 1.3 -1.7 0.0 -2.4 -1.4 -3.6 -2.5 -1.4 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.2 0.6 1.5 0.5 0.0 -1.4 0.7 -1.0 -1.0 -0.7 -1.2
Mouth/teeth dental problems: Dentures 0.5 0.9 2.6 -0.2 -0.7 0.6 0.0 0.9 -0.0 1.6 1.6 0.7 1.2
Asthma 0.3 0.6 1.3 0.0 -0.9 -1.1 0.0 0.5 -1.1 -0.7 -0.1 0.7 1.2
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 5.4 2.1 -0.3 2.3 0.0 0.1 2.2 1.9 0.2 0.5 -1.5
Medication: Cholesterol lowering 0.6 0.9 3.6 -0.4 0.2 1.8 0.0 -0.8 1.9 0.5 -0.2 -0.9 0.5
Depression (self-reported) 2.5 3.0 5.2 -1.7 -1.3 -1.5 0.0 2.1 -2.1 1.0 1.9 2.3 2.2
Medication: Lansoprazole 0.4 0.4 1.7 -1.3 -1.2 0.7 0.0 0.0 0.2 0.4 0.5 -0.1 -0.2
Prospective memory result 0.8 1.0 4.0 0.0 -2.0 0.1 0.0 1.4 -0.6 1.4 -0.3 1.2 0.7
Lung cancer (father) 0.4 0.4 2.1 0.7 0.5 0.8 0.0 -0.1 0.6 0.6 0.4 -0.2 1.4
Illnesses of mother 0.4 0.5 3.3 1.8 0.4 -0.1 0.0 -0.4 0.1 -0.5 -0.5 -0.8 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 3.5 0.1 1.9 -0.0 0.0 -1.7 0.2 -0.7 -1.6 -1.2 -1.8
Pulse wave Arterial Stiffness index 0.3 0.3 1.1 0.4 -0.3 0.6 0.0 -0.5 0.8 0.1 -0.1 -1.1 0.5
Impedance of arm (left) 0.4 1.9 6.6 -1.0 0.3 -2.6 0.0 -0.1 -1.6 -2.5 -1.5 0.3 -0.2
Arm fat mass (right) 0.6 2.4 9.2 0.1 -0.5 3.0 0.0 -0.3 1.9 2.3 1.4 -0.9 -1.6
Trunk predicted mass 0.3 1.6 4.1 1.6 -0.1 2.0 0.0 -0.0 1.6 2.0 0.6 -0.6 -1.5
Standing height 0.0 0.5 1.2 0.9 -0.6 -0.5 0.0 0.9 -0.5 0.3 -0.1 1.0 -1.1
Length of working week for main job 0.7 0.8 2.9 0.7 -0.3 0.8 0.0 -0.4 1.2 1.1 0.1 -1.1 -1.7
Exposure to tobacco smoke at home 0.5 0.6 2.0 0.0 -1.0 1.4 0.0 0.2 0.7 0.2 1.0 0.3 1.1
Breastfed as a baby 2.4 3.0 7.2 -1.0 1.3 0.7 0.0 -2.7 0.5 -2.0 -2.3 -1.7 -2.7
Tense / ‘highly strung’ 1.2 2.0 6.4 -0.2 -1.8 -0.0 0.0 2.5 -1.0 1.0 0.7 2.5 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 7.0 0.4 -2.6 -0.1 0.0 2.4 -1.4 0.8 1.5 2.6 1.4
Hair/balding pattern: Pattern 4 0.2 0.6 2.6 1.6 -0.8 0.7 0.0 0.2 -0.2 0.3 0.5 1.2 -0.5
Birth weight of first child 0.3 0.6 2.7 0.2 0.1 -1.1 0.0 0.0 -1.6 -0.6 -0.4 1.1 0.1
Peak expiratory flow (PEF) 0.5 1.1 8.8 -0.2 0.5 0.3 0.0 -0.4 -0.3 -0.1 -1.1 -0.1 -3.0
Pulse wave reflection index 0.7 0.8 3.8 -0.0 -0.8 1.9 0.0 -0.4 1.5 0.5 -0.3 -0.8 -0.0
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.8 0.1 -1.3 -0.3 0.0 2.2 -0.6 0.7 0.7 1.8 0.8
Loud music exposure frequency 1.6 1.8 7.1 -0.1 2.7 1.7 0.0 -1.0 1.4 -0.3 -0.7 -1.2 -1.6
Qualifications: O levels/GCSEs or equivalent 3.6 5.7 15.8 -0.3 0.9 -3.2 0.0 -2.4 -2.6 -4.0 -3.4 -1.4 -2.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.5 1.0 -0.6 0.1 -0.0 0.0 -1.0 -0.5 -0.9 -0.7 -0.9 -0.9
Blood clot in the leg (DVT) 0.3 0.4 1.8 -1.4 -0.2 1.0 0.0 0.2 0.6 0.8 0.1 0.5 0.2
Medication: Paracetamol 0.3 0.5 3.6 1.9 -0.2 -0.8 0.0 0.1 -0.4 0.3 0.3 -0.3 -0.1
Headache pain in last month 0.4 0.6 4.5 2.1 -0.2 -0.4 0.0 0.3 -0.6 0.4 0.0 0.5 0.8
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 4.3 0.5 0.1 -2.1 0.0 0.2 -2.0 -1.0 -0.1 0.7 -0.5
Glaucoma (self-reported) 0.6 0.7 2.2 0.3 0.2 -0.0 0.0 1.4 -0.4 1.1 1.3 1.5 0.4
Gout (self-reported) 0.3 0.4 1.2 1.0 0.3 -0.6 0.0 -0.5 -0.8 0.0 -0.7 -0.4 -1.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.0 -1.2 -0.4 -0.0 0.0 1.2 -0.5 1.0 1.4 0.7 0.6
Medication: Amlodipine 1.6 2.3 7.7 0.4 1.4 0.4 0.0 -2.7 0.7 -1.4 -1.7 -2.8 -0.4
Medication: Ventolin 100micrograms inhaler 1.3 1.7 6.2 -0.1 0.2 1.5 0.0 -1.3 2.5 -0.8 -1.4 -1.8 -0.7
Birth weight 0.2 0.4 1.1 0.6 1.0 -0.3 0.0 -0.6 0.7 -0.5 -0.7 -0.2 -0.9
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.7 1.3 0.8 0.4 0.0 -0.9 0.5 -0.8 -0.7 -1.3 0.9
High blood pressure (siblings) 1.0 1.4 3.1 -1.6 -1.5 -1.7 0.0 0.4 -1.8 -1.3 -0.5 0.4 1.0
Forced vital capacity (FVC), Best measure 0.3 1.2 3.3 -0.1 1.8 0.8 0.0 -1.4 1.1 -0.3 -1.1 -1.2 -1.5
Body fat percentage 0.5 2.0 7.3 -0.4 -0.7 2.7 0.0 0.4 1.5 2.3 1.9 -0.4 -0.5
Leg fat percentage (right) 0.8 2.7 8.9 -0.1 -1.0 3.0 0.0 0.9 1.8 2.8 2.3 -0.4 -0.4
Arm fat-free mass (right) 0.4 2.0 7.0 1.1 -0.2 2.6 0.0 -0.0 2.0 2.3 1.2 -0.6 -1.1
Exposure to tobacco smoke outside home 0.3 0.4 1.6 1.3 -0.8 -0.3 0.0 0.1 -0.3 0.2 1.0 -0.7 0.6
Comparative body size at age 10 1.8 4.9 16.1 1.3 2.6 -0.1 0.0 -3.5 1.3 -2.1 -1.6 -4.0 -1.8
Number of full brothers 0.3 0.3 1.2 -0.3 0.6 0.0 0.0 -0.8 -0.0 -0.2 -0.7 -0.8 -1.1
Worry too long after embarrassment 2.4 4.0 18.0 0.1 -1.6 -0.5 0.0 2.4 -1.1 1.7 0.9 3.0 4.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.5 -0.7 -1.1 -0.4 0.0 0.5 -1.2 -0.0 1.0 0.9 -0.1
Wheeze or whistling in the chest in last year 0.8 1.4 4.1 -0.8 -1.1 1.1 0.0 1.6 0.3 1.6 0.9 1.0 2.0
Number of children fathered 1.1 1.3 4.0 0.6 1.2 1.3 0.0 0.3 1.5 0.5 1.6 0.2 -2.0
Reason for reducing amount of alcohol drunk: Health precaution 3.1 3.7 10.4 -2.1 0.7 -3.2 0.0 -1.2 -2.4 -2.9 -2.3 -0.6 0.7
Age at first live birth 0.4 0.7 2.1 -0.9 0.0 -1.3 0.0 -0.2 -0.3 -1.2 -0.7 -0.2 1.5
Pulse wave peak to peak time 0.3 0.4 1.4 -0.5 0.4 -0.7 0.0 0.6 -1.0 -0.1 0.2 1.2 -0.5
Health satisfaction 0.7 1.0 2.7 -0.7 0.7 1.5 0.0 1.2 1.1 1.6 0.6 0.8 -0.2
Shortness of breath walking on level ground 0.9 1.1 3.7 -0.3 -1.0 0.2 0.0 1.9 -0.2 1.2 1.2 1.5 0.9
Qualifications: College or University degree 0.4 1.3 3.1 -1.2 -0.7 -1.8 0.0 -0.6 -1.2 -1.7 -1.4 1.1 0.1
Eye problems/disorders: None of the above 0.1 0.2 0.4 -0.5 0.6 0.5 0.0 -0.5 0.3 0.2 -0.2 -0.4 -0.1
Mouth/teeth dental problems: Loose teeth 0.8 0.9 4.1 -2.0 1.2 0.1 0.0 -0.5 0.3 -0.6 -0.6 -0.1 1.6
Emphysema/chronic bronchitis 1.1 1.3 3.8 1.9 -0.0 1.5 0.0 -0.2 1.5 0.9 1.9 -0.5 0.0
Medication for pain relief, constipation, heartburn 0.9 1.5 4.4 -1.9 0.7 -2.1 0.0 -0.3 -1.5 -1.7 -0.7 -0.6 0.6
Neck or shoulder pain in last month 0.5 0.7 2.9 1.7 0.0 0.6 0.0 -0.8 0.5 0.2 -0.0 -0.5 -1.6
Medication: Blood pressure 0.4 0.7 2.5 -0.1 1.6 1.1 0.0 -0.7 0.8 -0.3 -0.9 -0.9 0.3
Angina (self-reported) 0.2 0.2 1.0 -1.0 -0.3 0.2 0.0 -0.5 0.1 -0.8 -0.3 -0.1 0.5
Migraine (self-reported) 3.2 4.0 10.7 1.5 -3.0 -0.5 0.0 3.2 -1.5 1.7 1.5 3.3 0.2
Medication: Ibuprofen 2.2 2.6 8.6 1.9 -0.6 2.9 0.0 0.2 2.6 1.9 0.3 0.7 -1.7
Medication: Allopurinol 0.1 0.2 0.6 0.6 0.4 -0.6 0.0 0.1 -0.6 -0.0 -0.3 -0.1 -0.8
Medication: Omeprazole 1.0 1.2 2.8 -0.9 -1.7 -0.0 0.0 1.6 -0.4 1.1 1.1 1.7 0.6
Medication: Seretide 50 evohaler 0.5 0.5 2.2 1.5 0.9 0.9 0.0 0.3 0.8 1.0 -0.3 0.1 0.0
Mean time to correctly identify matches 1.0 2.0 5.0 -1.1 1.9 -0.9 0.0 -2.2 -0.6 -1.8 -1.6 -1.5 -0.4
Heart disease (mother) 0.5 0.5 3.8 -2.0 -0.3 0.7 0.0 0.1 -0.0 0.5 -0.4 0.2 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 2.5 1.4 -0.7 0.0 0.0 -0.3 0.0 -0.8 -0.8 -0.1 -1.6
Whole body fat mass 0.6 2.4 8.9 -0.1 -0.7 3.0 0.0 0.3 1.9 2.6 1.8 -0.5 -0.9
Leg fat mass (right) 0.9 3.3 11.5 0.1 -0.8 3.4 0.0 0.7 2.2 3.2 2.2 -0.4 -0.7
Arm predicted mass (right) 0.4 2.2 7.8 1.1 -0.1 2.8 0.0 -0.2 2.2 2.2 1.2 -0.7 -1.2
Pulse rate, automated reading 0.7 2.2 5.4 -1.3 -0.6 -2.2 0.0 1.5 -2.3 0.7 1.6 1.7 1.4
Alcohol intake frequency. 0.5 1.3 4.0 1.0 0.2 0.9 0.0 1.3 0.3 1.7 2.0 1.3 0.7
Comparative height size at age 10 0.2 0.9 4.1 0.6 0.3 -2.0 0.0 0.0 -1.5 -1.1 -0.5 0.3 -0.6
Number of full sisters 0.8 0.9 3.1 1.1 1.8 1.6 0.0 -0.6 1.2 0.1 -0.3 -0.1 -0.5
Suffer from ‘nerves’ 0.3 0.4 1.4 -1.2 0.3 0.7 0.0 0.7 0.3 -0.3 -0.1 0.9 0.6
Overall health rating 0.7 1.6 5.3 -0.7 -0.2 2.1 0.0 1.2 1.1 2.3 1.6 0.8 0.2
Chest pain or discomfort 0.7 1.1 3.3 -1.8 0.9 0.8 0.0 1.0 0.5 1.4 1.1 1.3 0.1
Had major operations 0.8 1.0 2.9 -0.3 0.0 1.7 0.0 0.4 1.3 1.0 1.4 0.5 1.3
Age at last live birth 2.4 3.6 14.0 -1.8 0.7 -2.5 0.0 -1.6 -1.2 -3.7 -2.4 -0.9 0.8
Family relationship satisfaction 1.2 1.5 5.4 -1.6 0.3 -1.3 0.0 -0.9 -1.2 -1.8 -2.3 -0.0 0.1
Leg pain on walking 2.3 2.8 6.7 -0.9 -2.3 -0.1 0.0 2.6 -1.4 1.4 2.5 2.2 0.5
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 6.4 2.5 -0.6 1.3 0.0 0.1 1.8 0.6 -0.8 -0.2 -0.4
Commuting to job workplace: Car/motor vehicle 1.0 1.2 4.0 -1.5 -0.3 1.9 0.0 -0.4 2.0 0.1 0.4 -0.9 -0.9
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.4 -1.0 -1.2 -0.9 0.0 0.3 -0.7 0.0 0.5 0.0 0.1
Medication: Aspirin 1.5 2.0 9.4 -0.2 -0.3 3.1 0.0 -0.5 2.7 1.2 0.0 -1.0 -0.5
Supplements: Vitamin C 0.4 0.4 1.5 -0.9 0.2 1.2 0.0 -0.7 0.8 -0.6 -0.5 -0.3 -0.5
Knee pain experienced in last month 2.5 3.9 9.5 1.4 -2.2 0.4 0.0 2.9 -1.1 2.7 2.4 3.1 0.2
Hypertension (Self-reported) 0.2 0.4 1.5 -0.5 0.5 1.1 0.0 -0.5 0.7 -0.3 -0.1 -1.2 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 4.8 -1.4 -1.7 0.7 0.0 2.2 -0.4 2.2 1.6 2.1 0.6
Illnesses of father: Heart disease 0.1 0.2 0.6 0.1 0.5 -0.3 0.0 0.4 -0.8 0.2 -0.7 -0.1 -0.5
Illnesses of siblings: Diabetes 1.3 1.6 5.5 -1.1 1.3 0.8 0.0 -1.7 1.1 -0.9 -1.5 -2.4 -0.5
Smoking status: Previous 0.3 0.5 2.1 -0.2 1.5 0.7 0.0 -0.7 1.0 0.3 -0.6 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 1.2 0.7 -0.3 -0.6 0.0 0.6 -0.8 -0.1 0.2 1.1 -0.3
Whole body fat-free mass 0.3 1.9 5.3 1.6 -0.2 2.3 0.0 -0.0 1.7 2.1 0.9 -0.4 -1.6
Leg fat-free mass (right) 0.4 2.1 6.2 1.5 -0.5 2.5 0.0 0.3 1.7 2.4 1.2 -0.1 -1.4
Arm fat percentage (left) 0.4 1.7 6.7 -0.0 -0.2 2.6 0.0 -0.4 1.7 1.8 1.1 -1.1 -1.2
Average weekly red wine intake 2.0 2.9 7.8 -0.8 0.8 -1.9 0.0 -2.2 -1.1 -2.7 -2.8 -1.7 -0.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 5.0 0.4 -0.8 -0.1 0.0 0.8 -0.5 0.0 0.0 0.6 2.2
Mood swings 0.4 0.7 2.3 -1.5 -0.8 -0.3 0.0 1.0 -0.8 -0.2 0.4 1.1 1.0
Loneliness, isolation 0.6 0.8 2.5 -0.5 0.6 0.7 0.0 -1.5 1.0 -0.6 -0.7 -1.6 1.0
Long-standing illness, disability or infirmity 0.8 1.2 2.9 -0.5 -0.8 1.0 0.0 1.4 0.6 1.3 1.7 1.4 1.1
Ever had bowel cancer screening 0.7 0.8 3.8 -1.3 -0.8 -0.6 0.0 0.4 -0.8 0.1 1.9 0.5 -0.2
Diabetes diagnosed by doctor 0.5 0.8 2.5 -0.5 0.5 1.6 0.0 -0.6 1.1 0.8 1.1 -1.1 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 2.3 1.1 -1.1 -1.1 0.0 1.0 -1.5 0.2 1.4 0.9 1.2
Friendships satisfaction 0.5 0.7 2.1 -1.4 -0.1 -1.2 0.0 0.2 -1.2 -0.1 -0.7 0.8 0.6
Qualifications: nursing, teaching 0.5 0.8 2.3 -0.4 0.5 -0.9 0.0 -0.7 -0.9 -1.2 -1.5 -0.7 -1.1
Commuting to job workplace: Walk 1.2 1.3 6.8 2.6 -1.2 -1.2 0.0 0.1 -1.6 -0.0 -0.0 0.4 0.7
Eye problems/disorders: Cataract 0.8 0.9 2.5 -0.7 -1.6 0.1 0.0 -0.7 1.2 -0.2 -1.1 -1.3 1.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.9 2.0 -0.7 0.6 0.0 0.8 0.1 1.2 1.9 0.4 -0.6
Medication for cholesterol 0.7 1.1 3.2 1.6 1.2 0.8 0.0 -0.7 1.8 -0.3 -0.8 -0.9 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.6 -0.0 -0.2 0.2 0.0 1.1 -0.2 1.1 1.1 1.2 0.7
Back pain experienced in last month 0.6 0.9 2.7 0.5 -1.6 -0.8 0.0 1.4 -0.6 0.5 0.3 1.6 -0.2
Mineral and other dietary supplements 1.0 1.4 4.5 2.0 1.6 0.9 0.0 -0.3 0.0 0.5 0.4 -1.3 -2.1
Breast cancer (self-reported) 0.2 0.3 0.7 0.7 0.2 0.8 0.0 -0.1 0.8 0.5 -0.2 0.1 -0.8
Asthma (self-reported) 0.2 0.4 1.2 0.1 -0.6 -0.9 0.0 0.3 -0.9 -0.7 -0.4 0.5 1.1
Osteoporosis (self-reported) 0.5 0.6 1.8 -0.8 -0.7 -0.6 0.0 -0.1 -0.7 -1.1 -1.1 -0.2 -1.3
Osteoarthritis (self-reported) 1.3 1.7 4.2 -0.2 -1.8 0.5 0.0 1.5 -0.3 2.0 2.0 1.4 0.8
Medication: Aspirin 1.5 2.0 8.5 -0.6 -0.7 2.9 0.0 -0.7 2.6 1.2 -0.0 -1.0 -0.7
Medication: Gliclazide 0.8 0.9 4.0 -0.5 0.1 0.9 0.0 -1.1 1.5 -0.4 -0.5 -2.0 0.1
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 -0.2 0.5 -0.3 0.0 -0.1 0.1 -0.2 0.1 0.3 0.6
Smoking status: Current 1.2 1.9 7.5 -0.1 0.8 2.1 0.0 -0.9 2.7 0.2 -0.4 -2.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.7 -0.1 0.8 -0.0 0.0 -0.8 0.0 0.1 -0.6 -0.7 -0.3
Whole body water mass 0.3 1.9 5.3 1.5 -0.3 2.3 0.0 -0.1 1.7 2.2 0.9 -0.4 -1.6
Leg predicted mass (right) 0.4 2.1 6.3 1.4 -0.5 2.5 0.0 0.2 1.8 2.4 1.2 -0.2 -1.5
Arm fat mass (left) 0.7 2.7 10.1 0.6 -0.6 3.2 0.0 -0.0 2.1 2.6 1.6 -0.7 -1.3
Number of self-reported non-cancer illnesses 0.3 0.6 2.0 -1.4 -1.0 -0.1 0.0 0.9 -0.9 0.4 0.8 0.5 -0.3
Average weekly champagne plus white wine intake 0.6 0.8 3.5 0.3 0.5 0.4 0.0 -0.8 0.7 -1.0 -1.1 -0.5 -1.9
Miserableness 0.3 0.6 3.2 0.3 -0.4 1.8 0.0 -0.1 1.3 -0.2 -0.4 -0.3 0.7
Guilty feelings 0.5 0.7 1.5 1.1 -0.9 -0.6 0.0 1.1 -0.7 0.6 1.2 0.9 0.8
Wears glasses or contact lenses 0.3 0.4 0.9 -0.7 -0.2 -1.0 0.0 -0.3 -0.6 -0.7 -1.0 -0.6 0.4
Ever taken oral contraceptive pill 0.8 0.9 7.0 2.6 -0.7 0.8 0.0 0.1 0.9 0.4 0.1 0.3 0.2
Hearing aid user 0.4 0.4 1.3 0.1 1.1 1.0 0.0 0.0 1.0 0.3 0.4 0.1 0.7
Mother’s age at death 1.1 1.3 5.3 -1.9 -0.1 -2.3 0.0 -0.3 -1.4 -1.1 -0.1 -0.2 1.1
Financial situation satisfaction 1.1 1.3 4.0 0.1 2.0 0.7 0.0 -1.1 1.0 -1.5 -1.5 -1.1 -1.0
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.6 0.2 0.9 1.5 0.0 -1.3 1.7 0.2 0.5 -1.2 -1.9
Commuting to job workplace: Public transport 0.8 0.9 3.7 0.7 -0.8 -1.3 0.0 0.2 -1.9 0.1 0.6 0.9 -1.4
Eye problems/disorders: Glaucoma 0.9 1.0 3.3 1.8 -0.0 -0.1 0.0 1.2 -0.3 0.9 1.5 1.5 0.5
Medication: Blood pressure 0.4 0.7 2.4 -1.6 -0.8 -0.9 0.0 -0.5 -0.8 -1.1 -1.1 -0.3 0.1
Pain type(s) experienced in last month: Hip pain 0.3 0.4 2.7 -0.0 -0.5 0.2 0.0 -0.7 0.2 -0.5 -0.3 -0.3 -1.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 4.3 -1.2 -0.5 -0.4 0.0 -0.2 1.0 -0.9 -0.5 0.0 2.1
High cholesterol (Self-reported) 0.6 1.1 3.2 0.7 -1.3 1.4 0.0 0.8 1.1 1.0 0.9 0.6 1.8
Medication: Bendroflumethiazide 0.6 0.9 3.3 -1.3 0.5 -0.7 0.0 -0.7 -0.4 -1.3 -1.8 -0.5 0.5
Medication: Paracetamol 0.6 0.9 6.2 2.5 -0.9 -0.4 0.0 0.5 -0.0 0.9 0.8 0.1 -0.2
Medication: Lisinopril 0.3 0.4 1.3 0.7 0.4 -0.6 0.0 -0.7 0.3 -1.1 -0.2 -0.3 0.7
Medication: Atorvastatin 0.1 0.2 0.8 -0.7 0.2 -0.5 0.0 -0.0 -0.2 -0.2 -0.9 0.2 0.3
Illnesses of father: High blood pressure 0.7 0.9 3.6 0.8 0.6 1.2 0.0 -1.0 0.2 -0.4 -0.1 -1.3 -1.9
Alcohol drinker status: Never 0.7 0.9 2.7 -1.0 -1.0 0.0 0.0 1.6 -0.3 0.5 1.2 1.5 0.3
Ever smoked 2.1 3.7 10.4 -1.3 1.6 3.2 0.0 -1.6 3.2 0.1 -0.9 -2.2 -2.0
Basal metabolic rate 0.4 2.3 7.0 1.4 -0.5 2.6 0.0 0.1 1.9 2.5 1.2 -0.4 -1.6
Leg fat percentage (left) 1.0 3.6 12.3 -0.0 -1.1 3.5 0.0 1.0 2.1 3.3 2.4 -0.3 -0.2
Arm fat-free mass (left) 0.5 2.4 7.8 1.1 -0.6 2.8 0.0 0.3 2.0 2.7 1.3 -0.3 -1.1
Number of operations (self-reported) 2.1 3.1 10.1 -1.3 -1.3 3.2 0.0 1.3 2.4 2.5 1.8 0.6 0.4
Average weekly beer plus cider intake 0.3 0.4 2.2 1.5 0.0 0.4 0.0 -0.5 0.5 0.3 -0.0 -0.9 0.1
Irritability 0.8 1.3 4.3 -0.4 -0.3 -1.3 0.0 -0.4 -1.0 -2.1 -1.6 1.0 -1.4
Risk taking 2.1 3.1 8.4 1.3 2.2 -1.0 0.0 -1.7 0.3 -2.6 -2.9 -1.3 -1.8
Ever had prostate specific antigen (PSA) test 4.0 4.6 12.0 -2.7 -3.0 -1.0 0.0 2.8 -1.5 0.2 1.1 3.5 2.4
Fractured/broken bones in last 5 years 0.5 0.7 2.4 -1.4 -1.5 -1.1 0.0 0.3 -0.9 -0.6 -0.1 0.3 -0.3
Age started oral contraceptive pill 1.0 1.3 6.7 -2.6 -0.6 -0.4 0.0 0.8 -0.7 0.1 1.0 1.0 1.6
Diastolic blood pressure, automated reading 0.2 0.6 2.1 -1.4 0.1 1.2 0.0 0.5 1.1 1.1 -0.2 -0.2 0.2
Ever depressed for a whole week 1.5 1.8 5.3 1.3 -2.3 0.6 0.0 1.7 0.2 2.0 0.8 1.4 1.1
Unable to work because of sickness or disability 2.0 2.5 5.7 0.2 2.4 1.0 0.0 -2.1 2.0 -1.6 -1.4 -2.3 -0.4
Commuting to job workplace: Cycle 0.5 0.7 1.9 0.1 1.4 -0.1 0.0 -1.0 0.2 -0.9 -1.0 -1.3 -0.4
Myopia 0.5 0.7 3.4 1.9 -0.4 -0.1 0.0 0.4 -0.7 0.3 1.2 0.9 0.2
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.5 0.6 -0.8 -0.9 0.0 0.7 -0.6 0.3 0.2 1.2 0.8
Cholesterol lowering medication 0.6 0.8 2.2 -0.5 -1.4 -0.1 0.0 0.8 -0.9 0.6 1.0 1.0 1.5
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.3 -0.2 -1.8 -0.4 0.0 1.2 -1.2 0.5 1.2 1.7 0.3
Pain experienced in last month 0.7 1.2 4.0 -2.0 1.0 -0.4 0.0 -1.1 0.7 -1.2 -1.2 -1.4 0.9
Supplements: Calcium 0.8 0.9 2.1 -1.2 -1.0 -1.4 0.0 -0.8 -1.2 -1.3 -0.7 0.1 -0.3
Basal cell carcinoma (self-reported) 1.1 1.3 4.0 1.9 -2.0 -1.5 0.0 0.7 -1.6 -0.4 -0.3 0.8 -0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.5 -1.2 -0.0 -0.4 0.0 -0.1 -0.9 -0.1 0.2 0.0 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.3 -1.2 -0.1 1.0 0.0 0.0 0.6 0.5 0.1 0.3 0.2
Heart disease (siblings) 2.1 2.6 7.2 -1.2 -0.9 -1.2 0.0 2.1 -1.9 1.2 1.7 1.8 2.7
Alcohol drinker status: Previous 0.4 0.4 1.9 -0.3 1.4 1.0 0.0 -0.1 0.9 0.4 0.5 -0.2 -0.2
Pack years of smoking 0.3 0.4 1.2 0.0 0.8 0.8 0.0 -0.4 1.1 -0.3 0.1 -0.3 -0.9
Impedance of whole body 0.3 1.3 5.4 -0.9 0.4 -1.9 0.0 -0.0 -1.2 -2.3 -1.3 0.2 0.1
Leg fat mass (left) 0.9 3.5 12.1 0.2 -0.9 3.5 0.0 0.8 2.2 3.3 2.2 -0.3 -0.7
Arm predicted mass (left) 0.5 2.4 8.4 1.4 -0.4 2.9 0.0 -0.2 2.1 2.2 1.0 -0.8 -1.6