Hub : Genes

TAF4B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0950	0.0340	2.1e-03	0.058	0.012	0.025	0.035	0.039	1.2e-07	1.0e-02	4.7e-04	4.2e-05	1.5e-05
2	GTEx	Cells EBV-transformed lymphocytes	0.2080	0.0770	2.1e-03	-0.001	NA	-0.002	NA	-0.002	3.5e-01	NA	3.8e-01	NA	3.6e-01
3	GTEx	Cells Transformed fibroblasts	0.1310	0.0460	2.8e-03	0.019	NA	0.038	NA	0.037	1.3e-02	NA	7.7e-04	NA	8.6e-04
4	GTEx	Testis	0.2010	0.0680	3.2e-03	0.119	NA	0.079	NA	0.073	6.1e-06	NA	2.2e-04	NA	3.8e-04
5	METSIM	Adipose	0.0613	0.0199	5.8e-05	0.018	0.029	0.026	0.029	0.012	9.0e-04	2.9e-05	8.2e-05	2.8e-05	5.4e-03
6	TCGA	Prostate Adenocarcinoma	0.0486	0.0298	9.7e-03	-0.002	0.008	0.016	NA	0.003	8.4e-01	4.3e-02	7.1e-03	NA	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	1.7	0.7	-0.6	-0.2	1.3	0.4	0.9
Bipolar Disorder or Schizophrenia	0.7	1.8	7.8	0.2	-1.1	-2.8	-0.2	-1.1	-0.5
Depressed Affect (Nagel 2018)	0.5	0.9	3.0	0.3	-1.7	0.5	-1.2	0.2	-0.9
Depression (Nagel 2018)	0.4	0.6	1.5	1.0	0.1	0.8	-0.7	0.3	1.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.9	1.4	1.2	0.4	0.7	0.9	-0.7
Neuroticism (Nagel 2018)	0.6	1.3	3.1	0.4	-1.8	-0.5	-1.6	0.1	-1.4
Schizophrenia (2018)	1.5	3.2	11.8	-0.3	-0.9	-3.4	-1.4	-1.7	-1.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.4	0.4	-1.1	0.1	-0.7	-0.7
Worry (Nagel 2018)	0.3	0.6	1.7	0.5	-1.3	0.2	-0.2	1.1	-0.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.7	0.1	-0.2	0.4	0.8	-1.3	0.0
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.1	-0.4	-0.5	-0.7	0.4	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	1.1	1.1	-0.1	-0.2	0.0	-0.3	0.3
Crohns Disease (2017)	0.5	1.1	2.5	-0.5	0.7	0.8	1.6	0.7	-1.5
Irritable Bowel Disease (IBD)	0.5	1.1	3.3	0.4	1.0	1.1	1.8	0.8	-0.3
Ulcerative Colitis (UC)	0.5	1.0	1.9	0.7	1.4	1.0	1.2	0.7	0.8
Major Depression (MDD)	0.7	0.8	2.2	-0.5	-0.5	-1.5	-0.8	-1.3	-0.0
Reaction Time	0.3	0.5	1.9	0.9	-0.3	-1.4	0.0	-0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.7	0.2	1.9	0.6	0.1	0.3	-0.8
Breast Cancer	1.1	2.7	13.0	-0.1	1.1	0.8	1.0	3.6	0.4
Ovarian Cancer	0.2	0.3	0.7	0.4	-0.3	0.8	0.5	0.7	-0.1
Prostate Cancer	0.4	0.5	2.2	0.0	0.6	0.1	0.8	-0.2	1.5
Age at First Birth	0.4	0.6	1.2	-1.1	0.4	-0.1	-1.1	0.8	-0.6
Bipolar Disorder (2011)	0.9	0.9	3.1	0.3	0.6	-0.3	1.1	1.8	0.7
Body Mass Index (BMI) (2010)	0.9	1.2	3.3	-0.8	-1.0	-0.8	-0.5	-1.1	-1.8
Coronary Artery Disease (CAD)	0.2	0.3	0.6	0.6	-0.5	-0.7	0.2	-0.1	-0.8
Crohns Disease (2012)	0.9	1.4	2.9	0.2	1.4	1.2	1.3	1.7	-0.6
Mean Putamen Volume	0.1	0.2	0.5	0.7	-0.1	-0.6	-0.1	0.1	-0.1
Fasting Glucose	0.6	0.7	2.0	-1.0	-0.7	0.4	-0.7	0.5	-1.4
HbA1C	0.5	0.6	2.1	0.2	-1.0	0.4	-0.6	-1.4	-0.1
HDL Cholesterol	0.2	0.4	1.0	0.1	0.2	1.0	-0.3	0.5	-0.9
LDL Cholesterol	0.3	0.5	1.8	0.4	0.1	0.1	1.3	-0.3	-1.0
Lupus	0.3	0.4	1.3	-0.5	0.6	-0.3	0.5	-0.1	-1.1
Neuroticism (2016)	0.7	1.1	3.0	0.3	-0.3	-1.6	-1.7	-0.9	-0.0
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.4	0.2	-1.0	-0.1	-0.9	0.1
Rheumatoid Arthritis	0.1	0.2	0.3	0.0	0.3	-0.4	-0.6	-0.6	-0.1
Schizophrenia (2014)	1.1	2.4	9.7	0.4	-0.9	-3.1	-1.2	-1.4	-0.7
Triglycerides	1.5	2.4	8.9	0.2	0.6	0.9	3.0	2.0	0.3
Type 2 Diabetes (T2D) (2012)	1.7	1.9	4.8	0.4	-2.2	0.4	-0.5	-2.0	-1.5
Ulcerative Colitis	0.5	0.8	1.5	0.7	0.3	1.1	1.2	1.2	0.1
Blood Eosinophil Count	0.2	1.3	5.1	2.3	0.5	-0.3	0.3	0.1	1.5
Blood Platelet Count	0.2	2.8	9.6	-1.2	-1.1	3.1	1.9	0.7	-0.1
Blood Red Count	0.4	4.2	8.6	-2.4	0.6	1.2	-2.9	-2.6	1.5
Blood White Count	0.3	2.2	6.0	0.7	-2.2	2.4	0.4	0.3	1.3
Heel T-Score	0.5	3.7	8.1	-1.9	-0.5	0.7	-2.4	-1.9	-2.8
BMI	2.1	11.9	17.8	-2.2	-4.2	-1.0	-3.7	-4.2	-4.1
Height	0.6	11.4	58.2	-1.3	7.6	-0.2	-0.6	1.3	2.6
Waist Hip Ratio (WHR)	0.3	1.2	4.2	-1.7	2.0	0.0	-0.5	-0.4	-0.2
Systolic Blood Pressure	0.1	0.6	1.9	-1.0	-1.4	-0.1	0.1	0.8	-0.4
Smoking Status	0.5	1.3	3.3	-0.1	0.8	-1.8	-0.9	-1.2	-1.3
Allergy or Eczema	0.4	1.1	1.8	-0.3	-1.1	-1.0	-1.3	-1.0	-1.0
Cardiovascular Disease	0.2	0.6	1.7	0.6	0.0	-0.6	1.1	1.3	0.1
Hypothyroidism (self reported)	1.0	2.2	5.0	-1.2	-0.0	-2.2	-1.5	-1.8	-1.2
Respiratory disease	1.4	3.1	8.6	-1.3	-2.2	-0.2	-1.4	-1.3	-2.9
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.7	-0.9	-1.0	-0.4	-2.2	-0.2	-2.0
Lung FEV1/FVC ratio	0.2	1.2	2.1	1.4	0.2	0.7	1.3	-1.3	-1.0
Lung FVC	0.2	0.8	2.3	-0.9	-0.9	-0.6	-0.4	-1.5	-0.5
Neuroticism	0.7	1.8	6.3	1.7	-2.5	0.8	0.5	0.5	-0.6
Chronotype (morning person)	0.5	1.2	3.1	-1.8	0.6	0.6	0.6	1.2	-1.2
Hair Pigment	0.1	2.2	4.9	1.1	-0.4	-1.1	-2.2	1.1	2.1
Tanning	0.0	0.4	1.1	-0.5	-0.4	0.3	0.5	0.8	-1.1
Hand grip strength (left)	0.6	1.6	4.9	-1.1	-0.4	-0.7	-2.2	0.6	1.6
Number of treatments/medications taken	0.7	1.2	3.3	1.4	0.0	1.0	1.8	1.1	-0.1
Average weekly spirits intake	1.0	1.2	4.1	0.4	0.8	-0.4	0.1	1.5	2.0
Sensitivity / hurt feelings	0.6	1.1	4.0	-0.7	-0.8	-0.8	-2.0	0.1	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	0.3	-0.3	0.5	-1.1	0.2	0.3
Hearing difficulty/problems: Yes	1.2	1.9	4.8	1.0	-0.1	2.1	2.2	-0.9	0.6
Relative age of first facial hair	0.4	0.8	1.5	-1.2	-0.8	-1.1	-1.0	0.3	0.5
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	7.1	-0.9	-1.2	-0.1	-1.1	-2.3	-2.7
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.0	0.3	1.7	-0.1	-0.7	1.6	1.7
Ever had hysterectomy (womb removed)	0.3	0.4	1.3	-0.2	-1.1	0.2	-0.9	-0.4	0.2
Systolic blood pressure, automated reading	0.7	2.0	8.3	-0.6	-2.9	-0.2	-0.6	-0.5	-1.7
Eye problems/disorders: Diabetes related eye disease	4.4	4.8	17.7	-4.2	-0.1	1.2	-1.0	-0.3	-3.0
Angina	1.4	1.9	4.3	-0.4	-2.1	-2.1	-1.3	-0.1	-1.0
Medication for hormone replacement therapy	0.2	0.2	0.9	0.3	0.0	-0.0	-0.6	1.0	0.2
Vitamin and mineral supplements	0.3	0.4	1.2	-0.7	0.0	-1.1	-0.3	-0.7	-0.3
Supplements: Zinc	0.4	0.5	1.4	-0.3	1.2	-0.3	-0.5	0.7	-0.6
Medication: Co-codamol	0.9	1.1	2.1	0.0	0.1	1.3	1.4	0.7	-1.5
Medication: Metformin	1.2	1.7	5.1	-0.2	-0.6	-1.4	-2.3	-1.3	-0.9
Diabetes (father)	0.3	0.4	1.2	0.9	-0.2	1.1	0.3	0.3	0.0
Diabetes (mother)	0.4	0.5	2.0	0.2	-0.5	-0.5	0.6	0.3	1.4
Severe depression (siblings)	0.3	0.3	0.7	-0.8	0.8	0.6	-0.2	0.2	-0.3
Pack years adult smoking proportion	0.5	0.7	1.8	0.3	-1.0	0.8	0.8	1.3	0.0
Impedance of leg (right)	1.2	6.0	17.0	2.2	2.4	-0.7	1.6	2.4	4.1
Leg fat-free mass (left)	0.7	3.7	7.4	-2.2	-0.9	0.3	-2.4	-2.7	-1.9
Trunk fat percentage	0.5	2.0	2.8	-1.6	-1.7	0.6	-1.4	-1.5	-1.6
Hand grip strength (right)	0.7	1.9	5.7	-0.8	1.0	-0.3	-1.8	0.6	2.4
Townsend deprivation index at recruitment	0.5	0.7	1.5	0.5	-1.1	0.8	1.2	0.8	-0.1
Current tobacco smoking	0.2	0.3	0.9	-0.2	0.9	-0.3	0.1	0.9	-0.0
Average weekly fortified wine intake	2.8	3.2	8.4	-1.1	-1.0	-2.6	-2.9	-1.4	-0.3
Maternal smoking around birth	0.1	0.2	0.6	0.5	-0.8	0.3	0.1	0.3	-0.2
Fed-up feelings	1.0	1.7	9.1	0.2	-3.0	0.9	-0.3	-0.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	0.6	-0.7	1.1	-0.1	0.1	0.9
Relative age voice broke	1.3	1.9	4.4	-0.7	-1.4	-1.5	-2.1	-1.5	-0.5
Taking other prescription medications	0.2	0.3	0.9	0.7	0.1	0.1	1.0	-0.0	-0.2
Age when periods started (menarche)	0.2	0.6	3.0	-1.7	0.2	-0.6	0.0	0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	-1.1	-0.2	0.9	-0.1	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	10.1	-2.3	0.4	-0.4	-3.2	-0.8	-0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.0	0.0	0.6	0.2	0.7	-0.3
Qualifications: CSEs or equivalent	1.0	1.3	3.5	-1.3	-1.9	0.3	-0.7	0.2	-1.3
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.9	0.0	0.9	0.9	0.1	-0.9
High blood pressure	0.5	1.3	4.6	-0.9	-2.1	-0.0	0.2	0.0	-1.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	-0.2	-0.2	-0.5	-0.9	-0.9	-0.1
Multivitamins +/- minerals	0.5	0.6	1.2	0.8	-1.1	1.0	0.7	-0.1	0.7
Stomach or abdominal pain in last month	0.5	0.6	1.4	-1.2	0.0	1.2	-0.7	0.4	-0.1
Supplements: Glucosamine	0.9	1.2	5.0	-0.5	1.0	2.2	-0.6	0.5	-0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.8	-0.8	-1.0	-0.9	-0.2	-0.7	-1.3
Medication: Atenolol	1.7	2.1	5.6	0.4	-2.0	-2.4	-1.2	-1.0	-0.6
Medication: Levothyroxine sodium	0.9	1.6	5.7	0.2	0.2	-2.4	-1.1	-1.6	-0.2
Sitting height	0.1	0.5	1.0	-1.0	1.0	-0.5	-0.9	-0.0	0.1
Chronic bronchitis/emphysema (father)	1.2	1.4	3.0	1.7	0.0	1.1	1.5	1.2	0.5
High blood pressure (mother)	0.3	0.4	1.8	-0.7	-0.4	-0.1	0.3	1.4	-0.1
Body mass index (BMI)	1.9	7.9	12.4	-2.1	-3.5	-0.1	-2.7	-3.4	-3.5
Impedance of leg (left)	1.2	6.0	13.8	1.5	3.2	-0.8	1.4	2.8	3.7
Leg predicted mass (left)	0.7	3.7	7.6	-2.1	-0.9	0.3	-2.4	-2.8	-1.9
Trunk fat mass	0.8	3.5	5.2	-2.1	-1.7	0.1	-2.2	-2.3	-2.0
Waist circumference	1.2	4.2	8.7	-2.0	-1.6	-0.4	-2.4	-3.0	-2.1
Number of incorrect matches in round	1.0	1.7	6.3	2.5	-0.6	-1.5	-0.3	0.1	1.1
Past tobacco smoking	0.8	1.6	3.2	0.8	-1.8	1.3	1.8	-0.0	0.8
Alcohol usually taken with meals	1.6	2.6	5.2	-2.0	0.1	-1.6	-2.3	-0.7	-1.7
Nervous feelings	0.5	1.0	2.6	0.0	-1.6	-0.7	-1.2	0.9	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	7.8	2.8	-0.6	1.6	0.9	0.2	1.4
Hearing difficulty/problems with background noise	0.3	0.5	1.1	0.4	-0.8	1.1	0.8	-0.4	-0.3
Hair/balding pattern: Pattern 2	0.4	0.5	2.0	0.1	-0.2	0.6	0.4	1.4	-0.5
Had menopause	1.1	1.3	3.9	-0.8	0.3	-1.4	-2.0	1.0	-0.6
Had other major operations	0.2	0.2	1.0	-1.0	-0.3	0.2	-0.4	0.2	0.1
Forced vital capacity (FVC)	0.4	1.6	3.7	0.1	-0.4	-1.4	-0.9	-1.9	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.9	-2.6	0.3	-0.5	-2.6	-0.5	-1.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.8	0.2	-1.4	-0.1	0.4	-1.7	0.1
Qualifications: None of the above	0.5	1.1	2.2	1.1	-1.5	1.2	1.1	0.1	0.8
Financial difficulties in last 2 years	0.3	0.3	1.3	-0.0	-0.1	0.7	0.3	-1.1	-0.4
Mouth/teeth dental problems	1.4	2.2	7.2	0.2	0.6	-2.7	-1.6	-1.0	1.4
Heart attack	1.5	1.9	3.6	1.5	0.5	1.0	1.8	1.9	1.0
Allergy	0.8	1.9	3.8	1.2	1.4	-0.6	1.3	1.4	2.0
Pain all over the body in last month	0.8	0.8	2.6	-0.5	-1.2	0.2	0.0	-1.6	-0.7
Diabetes (self-reported)	0.9	1.4	4.3	-0.9	-1.5	0.5	-0.9	-0.6	-2.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.2	0.8	-0.0	1.2	1.1	-0.6	1.5
Medication: Ramipril	1.0	1.2	4.3	-1.1	-0.4	-0.0	0.3	1.3	-2.1
Medication: Simvastatin	0.5	0.8	1.7	0.9	-0.8	0.0	1.3	-0.6	-1.2
Fluid intelligence score	0.2	0.4	1.5	0.4	0.6	-0.3	-0.6	0.3	-1.2
Illnesses of siblings	1.1	1.5	4.1	-0.9	-0.7	-2.0	-1.1	-1.1	-1.3
Neuroticism score	0.4	0.9	2.4	0.9	-1.6	0.3	-0.8	1.0	-0.4
Weight	1.1	5.4	8.9	-2.5	-1.6	-0.2	-2.9	-3.0	-2.4
Impedance of arm (right)	0.8	3.8	9.2	1.7	1.0	1.1	3.0	2.0	2.1
Arm fat percentage (right)	1.4	5.7	10.8	-1.8	-3.3	0.4	-1.6	-2.8	-3.1
Trunk fat-free mass	0.6	3.7	7.3	-2.1	0.3	-1.1	-2.7	-2.6	-1.5
Hip circumference	1.0	4.2	8.6	-1.1	-2.8	-0.5	-2.2	-2.9	-1.7
Time employed in main current job	0.2	0.3	1.2	0.1	1.1	0.1	-0.3	0.5	-0.3
Alcohol intake versus 10 years previously	1.2	1.8	5.8	-0.7	-0.2	2.4	2.1	0.1	-0.3
Father’s age at death	4.3	5.7	10.1	-3.2	-0.0	-0.7	-2.7	-2.5	-3.2
Worrier / anxious feelings	0.7	1.3	3.9	-1.3	0.5	0.9	-1.0	2.0	0.1
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	9.4	-0.2	-3.1	-0.2	-1.5	-2.7	-0.7
Falls in the last year	1.9	2.6	4.4	-0.8	1.9	1.5	1.2	2.1	1.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	1.1	0.2	-0.5	-1.1	-0.4	0.6
Number of live births	1.3	1.8	7.8	0.5	1.1	0.8	0.5	0.6	2.8
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.3	0.9	-0.0	-1.3	-0.8	-1.7	2.3
Pulse rate	1.1	1.9	6.7	-0.1	0.7	2.6	1.3	-0.9	1.2
Happiness	0.3	0.4	0.7	0.8	0.2	0.5	0.8	-0.5	0.4
Noisy workplace	0.9	1.1	3.5	-0.5	-0.0	1.6	1.9	-0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.0	-1.4	1.0	-1.3	-2.0	0.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	6.9	-0.3	2.6	0.6	-0.4	0.9	1.1
Mouth/teeth dental problems: Dentures	1.2	2.0	8.7	0.4	-1.1	3.0	1.2	-0.3	-0.5
Asthma	1.6	3.1	11.0	-0.9	-2.0	0.5	-0.5	-1.4	-3.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	0.7	-0.2	0.5	1.1	-1.2	0.6
Medication: Cholesterol lowering	1.5	2.3	6.1	1.0	-0.7	1.4	1.8	2.5	-0.9
Depression (self-reported)	2.3	2.8	7.7	-1.1	-1.9	-1.4	-1.4	-2.8	-0.3
Medication: Lansoprazole	0.7	0.8	3.7	0.1	-0.6	1.9	0.2	0.3	-0.6
Prospective memory result	0.4	0.4	1.4	0.4	0.7	-0.7	-0.3	1.2	0.3
Lung cancer (father)	0.8	0.9	1.9	1.0	-0.5	1.4	0.6	0.5	1.4
Illnesses of mother	1.5	1.9	3.8	-0.3	0.7	-1.9	-2.0	-1.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.7	0.6	0.1	0.3	0.1	-1.0	1.7
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	-0.5	1.1	-0.2	-0.1	-0.0	1.4
Impedance of arm (left)	0.9	4.2	8.0	1.6	1.3	1.3	2.8	2.5	2.2
Arm fat mass (right)	1.4	5.7	9.6	-2.1	-2.7	0.1	-2.2	-3.1	-2.8
Trunk predicted mass	0.7	3.9	7.6	-2.2	0.3	-1.1	-2.7	-2.8	-1.5
Standing height	0.4	3.7	16.2	-1.3	4.0	-0.1	-0.7	0.5	1.9
Length of working week for main job	0.5	0.5	1.0	-0.8	0.2	1.0	-0.5	1.0	0.4
Exposure to tobacco smoke at home	1.8	2.0	5.8	1.1	-1.9	-1.0	-0.5	-2.4	-0.3
Breastfed as a baby	2.0	2.5	6.2	-2.5	0.8	-0.1	-1.3	-1.1	-2.2
Tense / ‘highly strung’	0.5	0.9	3.1	0.9	-1.8	0.2	1.0	0.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	0.7	-1.4	0.1	-0.3	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.4	1.0	3.7	-0.0	0.5	-1.1	-1.9	-0.7	0.4
Birth weight of first child	0.2	0.3	1.5	-0.1	-0.4	-0.0	-0.5	-1.2	0.1
Peak expiratory flow (PEF)	0.5	1.2	3.8	1.2	-0.0	-0.2	0.4	-1.2	1.9
Pulse wave reflection index	0.4	0.5	1.1	0.2	0.7	-1.1	0.0	1.0	0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	0.2	-0.8	0.3	-0.2	-1.4	0.0
Loud music exposure frequency	2.2	2.4	4.3	0.2	-1.7	-1.2	-2.1	-1.4	-1.9
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	6.1	-2.5	0.6	-0.8	-1.6	-0.4	-2.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.4	-1.3	-0.2	0.1	0.4	1.1	-1.5
Blood clot in the leg (DVT)	0.5	0.7	2.2	-1.5	-0.1	1.2	-0.4	-0.2	-0.3
Medication: Paracetamol	0.7	1.2	2.8	0.9	-1.0	1.6	1.7	0.3	-0.0
Headache pain in last month	0.4	0.7	2.7	-0.1	-1.6	-0.5	-0.5	-0.4	-0.8
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.2	0.1	0.4	-1.6	-1.9	-2.3	1.1
Glaucoma (self-reported)	0.4	0.4	1.3	0.7	-0.8	0.0	0.2	-1.1	0.4
Gout (self-reported)	1.1	1.5	5.4	-2.3	-0.1	1.1	-0.5	0.8	-1.2
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	5.5	-1.4	-0.7	-2.2	-1.3	-2.4	-1.4
Medication: Amlodipine	1.8	2.6	6.8	0.7	1.0	2.3	2.6	1.1	0.7
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	1.1	-1.0	-0.2	0.9	-1.3	0.4
Birth weight	0.7	1.5	6.3	0.0	2.5	-0.7	-1.0	0.6	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.7	1.3	-0.0	-0.5	-0.1	0.3	-1.2
High blood pressure (siblings)	0.7	1.0	3.2	0.8	0.4	1.8	0.5	1.4	0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	2.1	-0.1	0.0	-0.1	-0.4	-1.2	1.5
Body fat percentage	0.9	3.7	6.4	-1.6	-2.5	0.0	-2.0	-2.2	-2.1
Leg fat percentage (right)	1.6	5.7	12.2	-1.1	-3.5	-1.0	-2.5	-3.1	-2.0
Arm fat-free mass (right)	1.0	5.0	12.6	-2.5	-0.1	-1.2	-3.5	-2.8	-1.4
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.2	-0.5	-0.9	-0.3	-1.0	-0.4
Comparative body size at age 10	1.3	3.6	10.3	-0.4	-1.4	-1.6	-3.2	-1.6	-2.0
Number of full brothers	1.4	1.8	5.0	-0.7	0.5	2.2	1.3	1.6	0.7
Worry too long after embarrassment	1.1	1.9	4.8	0.9	0.6	-2.2	-2.1	0.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.6	0.7	-0.6	0.9	0.4	-1.3	0.5
Wheeze or whistling in the chest in last year	0.7	1.3	3.0	-0.5	-1.7	-1.0	-0.6	-1.6	-0.8
Number of children fathered	0.6	0.7	2.6	0.4	-0.5	0.6	1.6	-0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	0.6	-0.7	0.0	0.0	0.4	-0.1
Age at first live birth	0.1	0.2	0.5	-0.5	0.5	-0.3	-0.7	0.1	-0.4
Pulse wave peak to peak time	0.4	0.5	2.2	0.2	-0.9	0.2	-0.1	0.1	-1.5
Health satisfaction	0.7	0.9	1.8	-1.3	-0.5	0.8	-1.1	-1.2	-0.5
Shortness of breath walking on level ground	0.6	0.7	1.6	-1.3	-0.6	0.9	-0.4	-0.5	-1.0
Qualifications: College or University degree	0.3	1.0	3.3	0.2	1.8	-0.5	-1.2	-0.7	-0.9
Eye problems/disorders: None of the above	0.4	0.5	1.6	0.7	1.2	-0.4	-0.2	0.6	0.3
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.6	1.1	-2.1	0.2	2.0	-1.6	-0.5
Emphysema/chronic bronchitis	1.0	1.1	1.9	-1.0	-1.1	0.2	-0.9	-1.2	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.3	2.8	-0.8	1.0	-1.5	-1.7	-0.6	0.8
Neck or shoulder pain in last month	0.7	1.0	3.4	1.3	-0.2	0.1	0.9	0.1	1.8
Medication: Blood pressure	1.5	2.6	4.6	-0.2	-0.8	2.1	1.9	2.2	-1.5
Angina (self-reported)	1.3	1.7	4.0	-0.4	-2.0	-2.0	-1.3	0.2	-0.8
Migraine (self-reported)	1.7	2.1	4.8	-2.2	0.5	0.3	-1.3	2.0	-1.3
Medication: Ibuprofen	0.9	1.1	1.9	1.4	-0.1	0.4	1.1	-1.4	1.1
Medication: Allopurinol	0.9	1.2	2.8	-1.7	0.9	0.3	-0.4	1.3	-1.4
Medication: Omeprazole	2.9	3.4	6.9	-2.2	-1.0	-1.8	-2.1	-0.3	-2.6
Medication: Seretide 50 evohaler	1.2	1.4	2.5	-0.0	-1.2	1.6	0.9	-1.2	-1.5
Mean time to correctly identify matches	0.6	1.2	3.6	1.6	-0.4	-1.9	-0.3	0.0	1.0
Heart disease (mother)	0.3	0.3	0.6	0.8	-0.7	0.6	0.2	0.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	5.0	2.2	-1.3	1.0	0.9	0.5	0.6
Whole body fat mass	1.1	4.5	7.1	-2.1	-2.1	-0.0	-2.7	-2.6	-2.2
Leg fat mass (right)	1.5	5.7	10.4	-1.8	-2.6	-0.6	-2.9	-3.2	-2.2
Arm predicted mass (right)	0.8	4.3	11.3	-2.5	0.4	-1.0	-3.4	-2.3	-1.3
Pulse rate, automated reading	0.6	2.1	7.6	1.0	1.3	2.8	1.1	-0.8	0.5
Alcohol intake frequency.	1.0	2.3	4.9	-1.6	-1.2	2.2	1.5	-1.0	-1.2
Comparative height size at age 10	0.3	1.5	7.3	-0.0	2.7	0.1	0.8	-0.9	0.5
Number of full sisters	0.9	1.1	3.2	-0.1	0.2	1.8	1.4	-0.9	0.7
Suffer from ‘nerves’	0.9	1.4	6.2	0.4	-2.5	-0.3	-0.8	-0.8	-0.9
Overall health rating	1.7	3.5	8.9	-1.3	-3.0	2.0	0.5	-1.2	-2.3
Chest pain or discomfort	1.4	2.0	5.1	-1.9	0.1	-0.2	-1.1	-1.4	-2.3
Had major operations	1.1	1.3	3.3	0.8	1.5	0.2	0.9	1.8	0.7
Age at last live birth	0.4	0.6	1.9	0.3	0.6	-1.4	-1.0	0.2	-0.2
Family relationship satisfaction	0.3	0.3	0.8	-0.6	0.9	0.3	-0.6	0.2	-0.6
Leg pain on walking	1.7	2.1	6.1	-2.1	1.2	2.5	0.6	-0.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	3.8	-0.9	-1.5	1.0	1.1	-1.7	-2.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.7	0.2	0.1	-0.3	-0.6	0.5	1.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.1	-0.7	-0.7	-0.4	0.3	0.1
Medication: Aspirin	0.3	0.5	1.6	0.3	-0.1	0.6	0.7	1.3	-0.4
Supplements: Vitamin C	0.2	0.3	0.5	0.3	0.7	0.5	-0.4	0.7	0.5
Knee pain experienced in last month	0.6	0.9	1.8	0.6	-1.3	-0.3	0.3	-1.1	1.3
Hypertension (Self-reported)	0.3	0.9	3.6	-0.7	-1.9	-0.1	0.1	0.3	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	-0.5	0.7	-0.4	-1.0	0.3	-0.8
Illnesses of father: Heart disease	1.7	2.4	10.2	3.2	-0.2	-0.1	1.2	0.6	1.6
Illnesses of siblings: Diabetes	0.6	0.8	1.6	-1.3	-0.2	0.9	-0.7	-0.7	-1.2
Smoking status: Previous	0.8	1.1	3.0	-0.7	1.1	-1.0	-1.7	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	6.9	-1.0	2.6	1.2	0.2	1.1	1.6
Whole body fat-free mass	0.7	3.9	8.3	-2.2	-0.2	-0.7	-2.9	-2.7	-1.6
Leg fat-free mass (right)	0.7	3.9	7.1	-2.5	-0.6	0.2	-2.4	-2.7	-2.1
Arm fat percentage (left)	1.4	5.6	11.2	-1.9	-3.3	0.5	-1.6	-2.6	-3.0
Average weekly red wine intake	1.8	2.6	5.6	0.6	1.9	-2.4	-1.9	-0.4	1.5
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.6	-1.0	-0.2	-1.0	-2.4	1.3	0.9
Mood swings	0.4	0.7	2.1	-0.5	-1.0	0.1	-1.4	0.2	-0.7
Loneliness, isolation	1.1	1.5	7.9	0.5	-2.8	0.1	-0.5	0.1	-0.9
Long-standing illness, disability or infirmity	1.0	1.5	2.8	0.5	-1.0	1.7	1.6	-1.4	-0.7
Ever had bowel cancer screening	1.2	1.5	4.5	0.7	0.1	2.1	1.4	1.3	0.2
Diabetes diagnosed by doctor	1.2	1.9	6.2	-0.9	-1.7	0.5	-0.9	-0.7	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.8	0.2	0.1	0.1	0.0	-0.4	1.7
Friendships satisfaction	0.8	1.0	2.1	0.8	0.7	1.2	1.4	1.2	0.1
Qualifications: nursing, teaching	2.2	3.5	13.7	-0.1	3.7	-0.5	-1.6	2.0	0.6
Commuting to job workplace: Walk	0.3	0.3	1.2	1.1	0.4	-0.0	0.6	0.5	0.2
Eye problems/disorders: Cataract	0.2	0.3	1.1	0.2	-1.0	0.3	0.5	-0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	3.3	5.2	11.7	0.2	1.9	3.1	1.8	3.4	1.6
Medication for cholesterol	0.3	0.5	1.7	0.7	0.5	0.0	0.1	-0.6	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.7	0.6	-0.5	0.4	1.9	-0.6	-1.5
Back pain experienced in last month	0.4	0.5	2.5	-0.1	-0.6	-0.6	0.0	-0.1	1.6
Mineral and other dietary supplements	0.4	0.6	1.8	0.8	-1.3	-0.6	0.4	-0.7	0.4
Breast cancer (self-reported)	1.2	1.5	2.6	-1.2	1.6	0.4	-1.6	1.0	1.0
Asthma (self-reported)	1.3	2.6	8.9	-0.7	-1.9	0.4	-0.7	-1.3	-3.0
Osteoporosis (self-reported)	1.8	2.2	5.3	2.0	-0.5	1.3	2.3	1.0	1.0
Osteoarthritis (self-reported)	0.6	0.8	2.3	0.5	-1.2	-0.1	-1.5	-0.7	0.5
Medication: Aspirin	0.3	0.4	1.2	0.5	-0.4	0.5	0.3	1.1	-0.4
Medication: Gliclazide	0.3	0.3	0.7	-0.3	-0.6	-0.2	-0.8	0.1	-0.8
Illnesses of father: None of the above (group 1)	1.1	1.4	3.7	-1.9	-1.0	0.0	-0.1	-1.6	-1.0
Smoking status: Current	0.2	0.3	0.9	-0.1	0.9	-0.7	0.2	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.0	0.7	-1.4	1.0	1.0	-0.6	0.6
Whole body water mass	0.7	4.1	8.4	-2.3	-0.1	-0.8	-2.9	-2.8	-1.7
Leg predicted mass (right)	0.7	3.9	7.2	-2.5	-0.6	0.2	-2.4	-2.7	-2.1
Arm fat mass (left)	1.4	5.6	8.3	-2.2	-2.7	0.1	-2.4	-2.9	-2.7
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	-0.3	-1.0	0.9	0.8	0.3	-1.5
Average weekly champagne plus white wine intake	0.6	0.8	3.0	-0.1	-1.0	0.1	-0.6	-0.3	-1.7
Miserableness	0.3	0.6	1.0	-0.4	-0.8	0.8	-1.0	-0.2	-0.9
Guilty feelings	0.3	0.5	1.8	0.6	-0.1	-0.3	-0.8	1.4	-0.1
Wears glasses or contact lenses	0.2	0.2	0.5	0.3	-0.1	-0.7	0.2	0.2	-0.7
Ever taken oral contraceptive pill	0.3	0.3	1.8	-0.1	1.4	0.1	0.0	0.2	-0.1
Hearing aid user	1.2	1.3	5.7	0.1	0.1	2.4	1.3	-0.2	-0.7
Mother’s age at death	0.3	0.4	0.9	-0.6	1.0	-0.3	-1.0	0.4	-0.2
Financial situation satisfaction	0.7	0.8	2.5	0.9	-0.1	0.2	0.7	-1.6	1.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	-0.5	0.0	-0.9	-0.4	-0.5	-0.4
Commuting to job workplace: Public transport	0.3	0.3	1.3	-0.4	-0.3	0.4	0.3	-0.5	-1.1
Eye problems/disorders: Glaucoma	0.7	0.8	2.6	1.6	-0.2	-0.2	0.7	-0.4	1.3
Medication: Blood pressure	1.0	1.9	4.6	-1.5	-1.2	-1.4	-1.0	-0.3	-2.2
Pain type(s) experienced in last month: Hip pain	0.8	1.1	1.8	-1.0	-1.3	0.9	-0.4	-1.1	-1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	0.3	0.5	0.0	0.1	1.0	0.8
High cholesterol (Self-reported)	0.4	0.7	1.6	0.3	-1.0	-0.6	1.3	0.3	-1.0
Medication: Bendroflumethiazide	0.4	0.6	1.6	1.0	-0.2	0.4	0.6	1.3	0.9
Medication: Paracetamol	0.3	0.4	1.0	1.0	-0.6	0.7	0.7	-0.0	-0.2
Medication: Lisinopril	1.6	2.0	5.4	-1.0	-2.3	-0.2	0.7	-1.3	-1.9
Medication: Atorvastatin	0.5	0.6	2.1	-0.2	-1.4	-0.2	-0.3	1.0	-0.6
Illnesses of father: High blood pressure	0.4	0.5	1.3	-0.4	0.8	-0.6	-1.1	0.8	0.2
Alcohol drinker status: Never	0.6	0.7	2.2	0.1	-1.5	-0.2	0.3	-1.3	0.4
Ever smoked	0.9	1.6	3.4	-1.2	1.5	-1.0	-1.8	0.4	-1.1
Basal metabolic rate	0.8	4.4	8.6	-2.4	-0.4	-0.5	-2.9	-2.9	-1.8
Leg fat percentage (left)	1.4	5.0	8.0	-1.4	-2.8	-1.0	-2.6	-2.7	-2.1
Arm fat-free mass (left)	0.8	4.0	9.6	-2.2	0.4	-1.1	-3.1	-2.6	-1.2
Number of operations (self-reported)	0.4	0.5	1.2	0.9	0.9	0.4	0.2	1.1	0.5
Average weekly beer plus cider intake	0.3	0.5	1.7	0.5	-1.3	0.4	-0.2	-0.2	0.9
Irritability	0.5	0.8	2.2	1.2	-1.5	0.4	0.2	-1.0	-0.1
Risk taking	0.6	0.9	4.5	2.1	0.1	0.2	0.7	-0.3	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.1	-0.8	0.3	-0.3	-0.4	-0.3
Fractured/broken bones in last 5 years	1.1	1.5	3.6	0.5	1.9	-0.1	0.8	1.6	1.2
Age started oral contraceptive pill	0.4	0.5	2.5	0.2	-0.1	-0.4	-1.6	0.7	-0.0
Diastolic blood pressure, automated reading	0.8	2.6	6.7	-0.9	-2.6	-0.1	-1.4	-1.4	-2.0
Ever depressed for a whole week	1.4	1.7	3.7	1.7	-1.6	-0.1	-0.9	-1.9	-0.3
Unable to work because of sickness or disability	0.6	0.7	2.0	1.0	0.9	0.2	0.6	0.3	1.4
Commuting to job workplace: Cycle	0.8	1.0	3.9	-0.6	2.0	-0.0	1.0	0.6	0.5
Myopia	0.4	0.6	1.7	-0.1	1.3	0.6	0.5	0.1	1.1
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.7	0.3	2.2	-0.5	-0.8	-0.1	1.5
Cholesterol lowering medication	2.1	3.1	6.3	-1.0	-2.5	-1.0	-0.4	-2.5	-2.0
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	5.8	-1.7	-1.1	-2.0	-2.2	-0.4	-2.4
Pain experienced in last month	1.1	1.8	3.3	-1.1	1.7	-0.4	-1.8	0.4	-1.8
Supplements: Calcium	0.1	0.1	0.4	0.3	-0.0	0.1	0.4	0.2	-0.6
Basal cell carcinoma (self-reported)	1.3	1.6	4.1	-1.0	2.0	-0.9	-1.0	1.5	-0.3
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.0	1.8	0.9	0.8	1.6	2.0	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.1	-1.4	0.1	1.2	-0.5	-0.0	-0.2
Heart disease (siblings)	1.8	2.1	4.3	1.4	0.6	1.1	1.9	1.2	2.1
Alcohol drinker status: Previous	0.6	0.6	3.0	-1.7	-0.6	0.3	0.3	0.3	-0.5
Pack years of smoking	0.5	0.7	2.0	0.3	-0.9	0.8	0.9	1.4	-0.3
Impedance of whole body	1.3	6.5	12.2	1.9	2.6	0.5	2.4	3.2	3.5
Leg fat mass (left)	1.4	5.3	9.2	-2.0	-2.2	-0.6	-3.0	-2.9	-2.2
Arm predicted mass (left)	0.9	4.5	11.2	-2.5	0.2	-1.0	-3.4	-2.6	-1.4