TWAS hub - TAGAP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1660	0.0620	5.7e-04	0.030	NA	0.022	NA	0.038	4.2e-03	NA	1.2e-02	NA	1.3e-03
2	NTR	Blood	0.0531	0.0172	1.6e-04	0.041	0.015	0.040	0.042	0.039	3.6e-13	8.7e-06	8.5e-13	2.1e-13	9.6e-13
3	YFS	Blood	0.0910	0.0206	1.3e-11	0.067	0.041	0.066	0.069	0.067	4.6e-21	2.0e-13	8.4e-21	1.4e-21	4.7e-21

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood White Count	7.9	58.6	78.2	4.9	-8.8	-8.6
Rheumatoid Arthritis	6.2	8.5	13.1	-0.2	3.6	3.5
Supplements: Vitamin C	5.0	5.9	7.1	2.1	-2.7	-2.5
Crohns Disease (2017)	4.9	10.8	15.4	1.6	-3.9	-3.8
Crohns Disease (2012)	4.7	7.5	9.6	1.9	-3.1	-3.1
Allergy or Eczema	4.6	12.2	18.7	0.1	-4.3	-4.2
Supplements: Calcium	4.6	5.1	5.8	2.4	-2.2	-2.1
Irritable Bowel Disease (IBD)	4.1	9.8	10.6	2.9	-3.3	-3.2
Supplements: Zinc	4.1	4.5	7.3	2.7	-1.6	-1.9
Lupus	3.3	5.0	6.1	1.7	2.5	2.5
Chronic bronchitis/emphysema (mother)	3.1	3.6	6.0	0.3	-2.5	-2.2
Gout (self-reported)	2.9	4.0	5.9	0.8	2.3	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.4	5.8	1.0	-2.4	-1.9
Chest pain or discomfort	2.9	4.2	6.7	-0.1	-2.5	-2.6
Handedness (chirality/laterality): Left-handed	2.9	3.5	5.4	0.4	-2.3	-2.2
Migraine (self-reported)	2.7	3.3	4.9	-1.3	-1.8	-2.2
Ulcerative Colitis	2.6	3.7	7.4	2.7	-1.3	-1.5
Myopia	2.4	3.4	5.8	-0.5	2.1	2.4
Coronary Artery Disease (CAD)	2.3	2.7	8.0	2.8	0.4	-0.0
Wheeze or whistling in the chest in last year	2.3	4.0	6.0	1.3	-2.1	-2.4
Ulcerative Colitis (UC)	2.2	4.2	8.0	2.8	-1.4	-1.6
Risk taking	2.2	3.3	4.0	2.0	-1.9	-1.6
Alcohol drinker status: Previous	2.2	2.5	4.1	0.4	-2.0	-1.8
Allergy	2.1	4.8	7.3	0.2	2.7	2.6
Body fat percentage	2.1	8.1	9.7	2.4	-3.1	-3.0
Trunk fat percentage	2.0	8.1	9.8	2.2	-3.1	-3.1
Commuting to job workplace: Cycle	2.0	2.4	3.6	-0.9	1.7	1.9
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.1	0.4	1.8	1.8
Hayfever, allergic rhinitis or eczema	1.9	4.0	6.2	-0.5	-2.5	-2.4
Chronic bronchitis/emphysema (father)	1.9	2.2	2.8	-1.4	-1.4	-1.7
Pulse rate, automated reading	1.9	6.0	6.7	2.3	-2.5	-2.6
Osteoporosis (self-reported)	1.9	2.3	3.0	1.1	-1.6	-1.7
Schizophrenia vs Biploar Disorder	1.8	2.4	3.3	-1.0	-1.8	-1.7
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	4.0	0.5	-2.0	-1.5
Lung cancer (father)	1.8	2.1	2.4	-1.3	-1.5	-1.5
Smoking status: Current	1.8	2.9	3.5	-1.5	-1.9	-1.7
Pain experienced in last month	1.8	3.1	4.7	2.2	1.6	1.4
Basal cell carcinoma (self-reported)	1.8	2.1	3.3	0.0	1.7	1.8
Current tobacco smoking	1.7	2.9	3.9	-1.1	-2.0	-1.9
Leg fat percentage (right)	1.7	6.1	6.9	2.3	-2.6	-2.5
Shortness of breath walking on level ground	1.7	2.0	5.9	2.4	-0.2	-0.1
Medication for cholesterol	1.7	2.6	4.6	-2.1	1.0	1.4
Breast cancer (self-reported)	1.7	2.0	3.5	1.9	-1.3	-0.9
Ovarian Cancer	1.6	2.1	6.1	2.5	0.5	0.3
Fed-up feelings	1.6	2.9	4.6	0.3	-2.1	-2.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.2	0.5	-1.7	-1.8
Breastfed as a baby	1.6	2.0	2.2	1.5	1.5	1.3
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.2	2.0	1.1	0.8
Qualifications: nursing, teaching	1.6	2.5	3.4	-1.4	1.4	1.9
Leg fat percentage (left)	1.6	5.7	6.6	2.1	-2.6	-2.5
Hair/balding pattern: Pattern 4	1.5	3.6	5.3	0.6	-2.3	-2.3
Pulse wave peak to peak time	1.5	1.8	3.7	-1.9	0.9	0.9
Age at First Birth	1.4	2.0	6.1	-2.5	0.2	0.1
Serious illness, injury or assault to yourself	1.4	1.7	2.3	-0.9	-1.4	-1.5
Supplements: Glucosamine	1.4	1.8	2.8	0.5	1.7	1.5
Qualifications: None of the above	1.4	3.1	4.2	1.3	-2.0	-1.9
Financial difficulties in last 2 years	1.4	1.9	2.4	-1.4	-1.5	-1.2
Mouth/teeth dental problems: Dentures	1.4	2.4	5.0	2.2	-1.1	-1.1
Number of full brothers	1.4	1.8	2.5	-0.9	1.4	1.6
Neck or shoulder pain in last month	1.4	2.0	4.5	-2.1	-0.8	-0.9
Medication: Seretide 50 evohaler	1.4	1.6	2.9	0.5	-1.3	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	3.2	-1.8	-1.5	-1.1
Mineral and other dietary supplements	1.4	1.8	2.4	-1.1	-1.6	-1.4
Medication: Paracetamol	1.4	2.2	6.5	-2.5	-0.2	-0.3
Angina	1.3	1.7	3.6	1.9	-0.8	-1.0
Trunk fat mass	1.3	5.7	7.2	1.7	-2.6	-2.7
Pulse wave Arterial Stiffness index	1.3	1.5	3.1	1.8	-0.8	-0.8
Medication: Paracetamol	1.3	2.2	5.5	-2.4	-0.8	-0.7
Medication: Allopurinol	1.3	1.7	2.9	-0.0	1.5	1.7
Alcohol intake frequency.	1.3	3.1	5.2	-0.4	-2.3	-2.0
Ever had bowel cancer screening	1.3	1.5	2.2	0.5	-1.5	-1.5
Back pain experienced in last month	1.3	2.0	2.4	-1.5	-1.6	-1.1
Medication: Gliclazide	1.3	1.4	2.3	0.6	1.2	1.5
Miserableness	1.3	2.3	6.5	-2.5	-0.6	-0.2
Hypothyroidism (self reported)	1.2	2.8	4.2	-1.1	2.1	1.8
Qualifications: CSEs or equivalent	1.2	1.6	1.8	-1.1	1.3	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.1	0.4	-1.8	-1.6
Headache pain in last month	1.2	2.0	3.7	-1.9	-0.9	-1.2
Angina (self-reported)	1.2	1.6	3.5	1.9	-0.6	-0.9
Overall health rating	1.2	2.6	4.1	-0.2	-2.0	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.0	0.4	-1.4	-1.3
Cholesterol lowering medication	1.2	1.8	4.5	2.1	-0.5	-0.8
Respiratory disease	1.1	2.3	4.0	0.2	-1.7	-2.0
Townsend deprivation index at recruitment	1.1	1.5	1.6	1.1	-1.3	-1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	1.9	1.0	1.4	1.1
Time employed in main current job	1.1	1.3	2.0	0.1	1.4	1.3
Eye problems/disorders: None of the above	1.1	1.3	2.0	-0.4	-1.4	-1.3
Whole body fat mass	1.1	4.6	5.5	1.7	-2.3	-2.3
Leg fat mass (right)	1.1	4.1	4.8	1.7	-2.2	-2.1
Illnesses of father: Heart disease	1.1	1.6	2.7	0.4	-1.4	-1.6
Hearing aid user	1.1	1.3	2.0	1.4	-0.8	-1.1
Commuting to job workplace: Public transport	1.1	1.3	2.1	1.5	0.8	1.1
Supplements: Fish oil (including cod liver oil)	1.1	1.5	2.2	1.5	1.0	1.1
Breast Cancer	1.0	2.4	4.2	2.0	1.4	1.0
Bipolar Disorder (2011)	1.0	1.0	1.0	1.0	1.0	1.0
Fasting Glucose	1.0	1.2	1.8	-0.5	-1.3	-1.3
HDL Cholesterol	1.0	1.6	4.7	2.2	0.5	0.0
Heel T-Score	1.0	8.3	14.0	-0.2	3.3	3.7
Hearing difficulty/problems: Yes	1.0	1.5	4.4	2.1	-0.2	-0.3
Relative age of first facial hair	1.0	2.1	2.6	1.4	-1.6	-1.3
Stomach or abdominal pain in last month	1.0	1.2	2.0	-0.5	-1.4	-1.2
Arm fat percentage (right)	1.0	3.8	4.7	1.5	-2.2	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.1	-1.1	-1.4	-1.2
Birth weight of first child	1.0	1.8	5.2	-2.3	0.5	0.4
Heart disease (mother)	1.0	1.2	2.0	0.3	1.4	1.2
Number of full sisters	1.0	1.2	1.7	0.9	1.1	1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.1	1.8	-0.3	-0.6
Arm fat percentage (left)	1.0	4.0	4.8	1.7	-2.2	-2.1
Mood swings	1.0	1.8	3.1	0.1	-1.8	-1.5
Mother’s age at death	1.0	1.3	1.4	-1.2	-1.1	-1.1
Alcohol drinker status: Never	1.0	1.2	1.8	0.2	-1.3	-1.3
Irritability	1.0	1.7	2.8	-0.3	1.5	1.7
Fractured/broken bones in last 5 years	1.0	1.3	2.0	0.9	1.1	1.4
Leg fat mass (left)	1.0	3.8	4.3	1.6	-2.1	-2.1
Medication for hormone replacement therapy	0.9	1.0	1.4	0.4	-1.1	-1.2
Medication: Co-codamol	0.9	1.1	2.0	-0.4	-1.0	-1.4
Severe depression (siblings)	0.9	1.0	2.7	-1.6	-0.5	-0.3
Pack years adult smoking proportion	0.9	1.4	1.8	1.3	-1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.8	-0.4	1.5	1.9
Medication: Lansoprazole	0.9	1.0	2.3	-0.5	-1.5	-0.8
Illnesses of mother	0.9	1.1	1.4	-1.2	0.8	1.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	1.8	-1.3	1.2	1.1
Exposure to tobacco smoke outside home	0.9	1.2	2.1	0.1	-1.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.2	1.5	-0.6	-0.8
Smoking status: Previous	0.9	1.4	2.7	1.6	1.0	0.8
Friendships satisfaction	0.9	1.1	1.9	1.4	-0.9	-0.9
Financial situation satisfaction	0.9	1.1	1.9	0.1	-1.4	-1.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.4	0.7	-1.0	-1.2
Relative age voice broke	0.8	1.2	2.1	0.3	-1.4	-1.2
Taking other prescription medications	0.8	1.2	1.9	0.2	-1.4	-1.3
Multivitamins +/- minerals	0.8	1.0	1.6	0.3	1.3	1.2
Medication: Simvastatin	0.8	1.1	2.6	1.6	-0.5	-0.7
Pulse rate	0.8	1.3	3.5	1.9	-0.4	-0.6
Knee pain experienced in last month	0.8	1.3	3.5	-1.9	0.0	0.5
Illnesses of father: High blood pressure	0.8	1.0	2.0	1.4	0.8	0.7
Age started oral contraceptive pill	0.8	1.0	1.3	0.7	1.1	1.1
Unable to work because of sickness or disability	0.8	1.0	2.8	-1.7	-0.4	-0.1
HbA1C	0.7	0.8	1.6	-1.3	-0.6	-0.6
Blood Eosinophil Count	0.7	5.5	15.2	3.9	-0.5	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.0	-0.0	1.2	1.7
Waist circumference	0.7	2.7	3.4	1.4	-1.8	-1.7
Nervous feelings	0.7	1.3	2.6	1.6	-0.7	-0.9
Loud music exposure frequency	0.7	0.8	2.2	1.5	0.1	0.3
Birth weight	0.7	1.5	2.8	0.2	-1.2	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.6	0.1	-1.3	-1.1
Health satisfaction	0.7	0.9	1.6	0.7	-1.3	-0.9
Medication: Ibuprofen	0.7	0.8	2.3	-1.5	-0.2	-0.2
Family relationship satisfaction	0.7	0.9	1.6	0.4	-1.3	-0.9
Loneliness, isolation	0.7	1.0	2.8	-1.7	-0.4	0.1
Long-standing illness, disability or infirmity	0.7	1.1	1.6	0.6	-1.2	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	0.9	-1.0	0.9	0.8
Arm fat mass (left)	0.7	2.7	3.2	1.4	-1.8	-1.8
Guilty feelings	0.7	1.0	2.1	-1.5	0.8	0.5
High cholesterol (Self-reported)	0.7	1.2	3.3	1.8	-0.3	-0.5
Pack years of smoking	0.7	1.1	1.4	1.2	-0.9	-1.0
Average weekly spirits intake	0.6	0.8	2.1	1.4	0.5	-0.0
Medication: Metformin	0.6	0.8	2.1	1.4	0.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.7	1.3	-0.5	-0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	-0.1	0.9	1.0
Body mass index (BMI)	0.6	2.6	3.5	1.0	-1.9	-1.8
Medication: Ramipril	0.6	0.8	1.4	1.2	0.8	0.7
Illnesses of siblings	0.6	0.8	1.2	0.6	-1.1	-1.0
Hair/balding pattern: Pattern 3	0.6	1.0	1.6	0.5	-1.3	-1.0
Arm fat mass (right)	0.6	2.3	3.0	1.1	-1.7	-1.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.1	1.0	0.9	0.6
Medication: Blood pressure	0.6	1.0	1.3	1.1	1.2	0.7
Leg pain on walking	0.6	0.7	1.7	1.3	0.3	0.6
Diabetes diagnosed by doctor	0.6	0.9	1.3	0.5	1.1	1.2
Medication: Atorvastatin	0.6	0.7	1.6	1.2	-0.3	-0.6
Worry (Nagel 2018)	0.5	1.0	1.8	1.4	-0.9	-0.7
Major Depression (MDD)	0.5	0.6	1.0	0.2	-0.9	-1.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-1.2	-0.7	-0.5
Triglycerides	0.5	0.8	1.3	-1.1	0.5	0.9
Systolic Blood Pressure	0.5	2.4	7.0	2.6	0.6	-0.1
Vitamin and mineral supplements	0.5	0.7	1.4	-1.2	0.5	0.7
Impedance of leg (left)	0.5	2.2	4.9	2.2	-0.9	-1.0
Hearing difficulty/problems with background noise	0.5	0.8	2.2	1.5	-0.2	-0.4
Had menopause	0.5	0.6	1.7	1.3	0.0	0.1
Fluid intelligence score	0.5	1.0	2.2	0.1	1.5	0.9
Hip circumference	0.5	2.0	3.0	0.4	-1.7	-1.7
Happiness	0.5	0.6	1.9	1.4	-0.2	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.2	-0.9	-1.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.7	-0.1	1.3	1.1
High blood pressure (siblings)	0.5	0.8	1.0	-0.8	1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	1.3	0.3	-0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-0.4	0.7	1.0
Average weekly champagne plus white wine intake	0.5	0.7	1.1	-1.0	0.6	0.8
Medication: Bendroflumethiazide	0.5	0.7	1.2	0.4	1.1	0.9
Diastolic blood pressure, automated reading	0.5	1.4	3.4	-1.8	0.3	0.9
Bipolar Disorder (2018)	0.4	0.7	1.8	1.3	0.4	0.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.4	1.2	0.3	0.1
LDL Cholesterol	0.4	0.7	0.7	-0.8	0.8	0.8
Blood Platelet Count	0.4	4.8	8.0	-0.6	-2.8	-2.5
BMI	0.4	2.4	3.2	0.9	-1.8	-1.8
Diabetes (father)	0.4	0.5	0.9	-0.2	-1.0	-0.7
Average weekly fortified wine intake	0.4	0.5	1.5	1.2	0.0	-0.1
High blood pressure (mother)	0.4	0.6	0.9	0.9	-0.3	-0.9
Hair/balding pattern: Pattern 2	0.4	0.6	0.8	0.1	0.9	0.9
Forced vital capacity (FVC)	0.4	1.4	2.1	-0.5	1.4	1.4
Diabetes (self-reported)	0.4	0.7	1.0	0.4	0.9	1.0
Weight	0.4	1.8	2.7	0.3	-1.6	-1.6
Father’s age at death	0.4	0.6	1.0	0.4	-0.8	-1.0
Worrier / anxious feelings	0.4	0.7	1.0	0.7	-1.0	-0.7
Number of live births	0.4	0.5	1.5	1.2	0.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.5	-0.1	1.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.9	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	1.8	-0.8	1.3	1.3
Forced vital capacity (FVC), Best measure	0.4	1.6	2.1	-0.8	1.5	1.4
Comparative height size at age 10	0.4	2.3	2.7	-1.6	1.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.3	-1.1	-0.9	-0.8
Eye problems/disorders: Cataract	0.4	0.5	0.6	0.8	0.7	0.5
Osteoarthritis (self-reported)	0.4	0.5	0.5	0.7	-0.7	-0.6
Number of self-reported non-cancer illnesses	0.4	0.6	0.8	0.7	-0.7	-0.9
Eye problems/disorders: Glaucoma	0.4	0.4	0.7	0.4	-0.7	-0.8
Medication: Lisinopril	0.4	0.5	0.6	0.7	0.7	0.6
Number of operations (self-reported)	0.4	0.6	0.8	-0.6	-0.7	-0.9
Ever depressed for a whole week	0.4	0.5	1.3	1.2	0.3	0.2
Impedance of whole body	0.4	2.0	2.2	1.4	-1.4	-1.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	-1.2	-0.6	-0.3
Depression (Nagel 2018)	0.3	0.4	0.6	-0.3	-0.7	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.5	-0.4	1.2	1.0
Lung FEV1/FVC ratio	0.3	1.3	2.9	-1.7	0.8	0.6
Lung FVC	0.3	1.6	3.0	0.5	1.2	1.7
Chronotype (morning person)	0.3	0.8	1.2	-0.7	1.1	0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	0.5	-0.6	-0.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.8	0.5	0.2
Diabetes (mother)	0.3	0.4	1.2	1.1	-0.1	-0.0
Impedance of leg (right)	0.3	1.6	3.7	1.9	-0.8	-0.8
Maternal smoking around birth	0.3	0.4	0.7	0.9	-0.3	-0.7
Age when periods started (menarche)	0.3	0.7	1.6	-1.3	0.4	0.4
Medication: Atenolol	0.3	0.4	0.7	0.1	0.7	0.8
Alcohol intake versus 10 years previously	0.3	0.4	1.1	-1.0	-0.3	-0.3
Falls in the last year	0.3	0.4	1.2	-1.1	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.3	-0.6	1.1	1.1
Noisy workplace	0.3	0.4	0.5	0.7	-0.6	-0.6
Length of working week for main job	0.3	0.4	1.1	1.0	-0.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.2	-0.8	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.8	0.5	0.5
Average weekly red wine intake	0.3	0.4	1.1	1.1	0.2	-0.4
Medication: Blood pressure	0.3	0.5	1.4	1.2	-0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	-1.0	0.2	0.2
Average weekly beer plus cider intake	0.3	0.4	0.8	0.9	0.5	0.4
Alzheimer’s Disease (in father)	0.2	0.3	0.6	0.2	-0.8	-0.3
Reaction Time	0.2	0.3	1.0	1.0	0.0	-0.1
Cardiovascular Disease	0.2	0.5	1.1	1.1	0.6	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	0.6	0.5	0.7
Number of treatments/medications taken	0.2	0.3	0.5	0.7	-0.3	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	0.3	-0.5	-0.5
Systolic blood pressure, automated reading	0.2	0.5	0.9	0.8	-0.3	-0.9
Hand grip strength (right)	0.2	0.5	0.8	0.4	0.9	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.9	0.0	-0.0
Past tobacco smoking	0.2	0.3	0.8	-0.9	-0.3	-0.2
Alcohol usually taken with meals	0.2	0.3	0.6	-0.8	0.4	0.1
Had other major operations	0.2	0.3	0.7	-0.9	0.3	0.2
Mouth/teeth dental problems	0.2	0.3	0.8	-0.9	0.2	0.2
Pain all over the body in last month	0.2	0.2	0.4	0.1	-0.6	-0.4
Trunk fat-free mass	0.2	1.1	2.9	-1.7	0.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.2	0.5	-0.3	-0.5
Impedance of arm (left)	0.2	0.9	1.2	0.7	-1.0	-1.1
Trunk predicted mass	0.2	1.1	2.8	-1.7	0.6	0.3
Peak expiratory flow (PEF)	0.2	0.4	0.9	-0.9	-0.3	-0.4
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.7	-0.3	-0.1
Medication: Amlodipine	0.2	0.3	0.5	-0.7	0.7	0.0
Worry too long after embarrassment	0.2	0.4	0.5	-0.5	-0.7	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	0.7	0.5	0.5
Mean time to correctly identify matches	0.2	0.4	1.0	1.0	0.2	0.2
Suffer from ‘nerves’	0.2	0.4	0.5	0.7	-0.7	-0.3
Had major operations	0.2	0.3	0.5	-0.2	-0.6	-0.7
Medication: Aspirin	0.2	0.2	0.5	0.7	-0.2	-0.4
Hypertension (Self-reported)	0.2	0.6	1.6	1.2	0.1	-0.3
Whole body fat-free mass	0.2	0.9	2.7	-1.6	0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.6	-0.5	0.8	0.8
Leg predicted mass (right)	0.2	0.8	2.4	-1.5	-0.2	-0.3
Wears glasses or contact lenses	0.2	0.3	0.5	-0.4	0.3	0.7
Ever smoked	0.2	0.4	0.5	0.5	-0.7	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.4	-1.2	-0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.3	0.7	0.5
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	0.6	0.0	-0.0
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.0	-0.7	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.4	-0.4	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.2	0.6	0.2
Mean Putamen Volume	0.1	0.1	0.4	-0.6	0.1	0.1
Neuroticism (2016)	0.1	0.1	0.2	-0.4	0.0	0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.2	0.5	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	-0.4	-0.3	0.0
Blood Red Count	0.1	1.1	3.2	1.8	-0.4	-0.2
Waist Hip Ratio (WHR)	0.1	0.3	0.8	0.9	-0.1	-0.1
Smoking Status	0.1	0.3	0.4	0.2	-0.7	-0.7
Tanning	0.1	0.8	1.5	0.2	-0.9	-1.2
Hand grip strength (left)	0.1	0.1	0.4	0.2	0.6	0.1
Sensitivity / hurt feelings	0.1	0.3	0.3	-0.3	-0.6	-0.6
Leg fat-free mass (left)	0.1	0.7	1.8	-1.3	-0.4	-0.5
High blood pressure	0.1	0.4	1.0	1.0	0.2	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.4	0.3	0.5
Sitting height	0.1	0.7	1.9	-1.4	-0.1	-0.2
Leg predicted mass (left)	0.1	0.7	1.7	-1.3	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	-0.3	-0.4	-0.1
Heart attack	0.1	0.2	0.4	-0.2	0.6	0.4
Neuroticism score	0.1	0.2	0.4	-0.5	-0.6	-0.3
Impedance of arm (right)	0.1	0.7	1.1	0.4	-0.9	-1.0
Asthma	0.1	0.2	0.3	0.0	-0.5	-0.6
Medication: Cholesterol lowering	0.1	0.2	0.5	0.7	0.0	-0.3
Depression (self-reported)	0.1	0.1	0.2	-0.4	0.0	0.3
Prospective memory result	0.1	0.2	0.3	0.2	-0.4	-0.5
Standing height	0.1	0.6	1.8	-1.3	0.2	-0.2
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.3	0.1	0.3
Tense / ‘highly strung’	0.1	0.1	0.2	0.0	0.4	0.3
Pulse wave reflection index	0.1	0.1	0.3	-0.2	-0.5	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.3	0.3	0.6
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	-0.1	-0.2
Comparative body size at age 10	0.1	0.4	0.5	-0.6	0.7	0.6
Age at first live birth	0.1	0.1	0.2	0.1	-0.5	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.5	0.3	0.2
Medication: Omeprazole	0.1	0.1	0.1	-0.2	0.3	0.4
Arm predicted mass (right)	0.1	0.3	0.6	-0.8	-0.3	-0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.1	-0.5	-0.2
Leg fat-free mass (right)	0.1	0.8	2.1	-1.4	-0.2	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	0.3	0.4
Asthma (self-reported)	0.1	0.3	0.5	0.2	-0.6	-0.7
Medication: Aspirin	0.1	0.1	0.4	0.7	0.0	0.0
Whole body water mass	0.1	0.8	2.3	-1.5	0.2	-0.0
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.5	0.7	0.1	-0.2
Basal metabolic rate	0.1	0.4	1.0	-1.0	-0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.3	0.2	0.3
Heart disease (siblings)	0.1	0.2	0.3	-0.4	0.5	0.2
Schizophrenia (2018)	0.0	0.1	0.1	-0.3	-0.4	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.1	-0.3	-0.0	-0.1
Height	0.0	0.7	1.2	0.7	1.1	0.6
Neuroticism	0.0	0.0	0.0	0.0	-0.1	0.2
Hair Pigment	0.0	0.9	2.1	-0.7	-1.4	-0.5
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.2	0.0	0.2
Number of incorrect matches in round	0.0	0.0	0.0	-0.1	-0.1	-0.0
Arm fat-free mass (right)	0.0	0.2	0.5	-0.7	0.0	-0.1
Number of children fathered	0.0	0.0	0.0	0.2	-0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.3	0.1	0.0
Qualifications: College or University degree	0.0	0.0	0.0	0.2	-0.0	0.1
Age at last live birth	0.0	0.0	0.0	0.2	0.2	0.1
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.2	0.1	-0.2
Arm fat-free mass (left)	0.0	0.2	0.4	-0.6	-0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.3	-0.1	0.1
Arm predicted mass (left)	0.0	0.2	0.4	-0.6	-0.1	-0.3

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