Hub : Genes

TANC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.2840	0.1190	0.0090	0.049	NA	0.028	NA	0.088	9.1e-03	NA	3.9e-02	NA	6.8e-04
2	GTEx	Colon Transverse	0.1090	0.0460	0.0016	0.051	NA	0.057	NA	0.040	1.8e-03	NA	1.1e-03	NA	5.5e-03
3	GTEx	Muscle Skeletal	0.0842	0.0345	0.0015	0.046	NA	0.010	NA	0.021	2.6e-05	NA	3.3e-02	NA	3.7e-03
4	NTR	Blood	0.0135	0.0070	0.0015	0.001	0.010	0.004	0.011	0.003	1.0e-01	2.8e-04	1.8e-02	1.4e-04	3.4e-02
5	YFS	Blood	0.0696	0.0172	0.0000	0.097	0.093	0.098	0.097	0.098	6.5e-30	9.6e-29	2.7e-30	3.9e-30	3.2e-30

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	1.4	0.2	0.8	-1.2	-0.2	0.5
Bipolar Disorder or Schizophrenia	0.6	1.6	5.7	0.4	2.4	-1.2	0.6	0.0
Depressed Affect (Nagel 2018)	2.4	5.0	8.5	-2.4	2.0	-1.8	-1.9	-2.9
Depression (Nagel 2018)	1.0	1.4	3.3	-1.8	0.2	-1.5	-0.8	-1.0
Intelligence (Savage-Jansen 2018)	3.1	9.6	20.8	2.3	-2.3	3.3	4.6	2.3
Neuroticism (Nagel 2018)	0.8	1.9	4.2	-2.0	-0.9	1.6	1.4	0.4
Schizophrenia (2018)	0.7	1.5	5.7	0.4	2.4	-0.7	0.9	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	-0.7	0.6	0.1	0.5	-0.0
Worry (Nagel 2018)	4.8	10.2	19.7	-0.7	-4.4	4.4	2.2	2.6
Alzheimer’s Disease (in mother)	0.7	0.8	2.7	0.0	0.5	-0.6	1.6	0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.5	0.8	0.3	0.0	0.7
Alzheimer’s Disease (including proxy)	1.4	2.0	5.3	-0.5	0.6	-0.6	2.3	2.0
Crohns Disease (2017)	0.4	0.9	1.6	-1.2	-1.0	0.2	-0.3	1.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-1.1	-0.4	0.6	0.4	0.7
Ulcerative Colitis (UC)	0.2	0.5	1.5	0.0	0.5	0.7	1.2	-0.0
Major Depression (MDD)	1.9	2.3	6.5	-1.0	0.6	0.5	-1.8	-2.5
Reaction Time	2.0	3.8	9.2	-0.2	2.8	-3.0	-0.3	-1.4
Verbal and Numeric Reasoning (VNR)	2.6	6.3	14.0	1.7	-1.0	3.2	3.7	1.7
Breast Cancer	0.6	1.4	5.3	-0.5	2.3	-0.8	-0.5	-0.6
Ovarian Cancer	0.6	0.8	1.6	-0.7	-1.3	0.7	-0.9	0.8
Prostate Cancer	1.3	1.8	4.5	-1.1	2.1	-1.9	0.3	-0.2
Age at First Birth	1.4	2.1	7.4	0.8	-0.2	1.2	2.7	0.9
Bipolar Disorder (2011)	1.1	1.1	2.2	1.3	-0.0	0.0	1.2	1.5
Body Mass Index (BMI) (2010)	2.5	3.4	8.7	-2.3	-1.0	-0.4	-2.9	-1.4
Coronary Artery Disease (CAD)	1.9	2.3	3.4	1.6	-0.7	1.6	1.8	1.5
Crohns Disease (2012)	0.1	0.1	0.3	0.0	-0.5	-0.2	-0.6	0.1
Mean Putamen Volume	0.7	0.8	2.4	-1.5	-0.4	-0.3	-0.9	-0.8
Fasting Glucose	1.7	2.1	5.2	-0.8	-1.8	2.3	-0.5	1.0
HbA1C	0.4	0.5	0.9	0.9	-0.8	0.3	-0.0	0.9
HDL Cholesterol	0.3	0.6	1.5	1.2	-0.0	0.5	1.0	0.2
LDL Cholesterol	0.7	1.2	4.1	0.7	-0.9	2.0	-0.4	-0.5
Lupus	2.0	3.1	9.2	1.5	-1.0	3.0	1.1	1.4
Neuroticism (2016)	1.5	2.1	4.1	-0.7	-1.8	1.0	1.4	2.0
Primary Biliary Cirrhosis	0.1	0.1	0.4	-0.0	0.1	0.5	-0.6	0.2
Rheumatoid Arthritis	0.9	1.2	4.4	-1.2	2.1	0.1	0.5	-0.3
Schizophrenia (2014)	1.0	2.1	8.5	0.4	2.9	-0.6	1.2	-0.3
Triglycerides	0.1	0.1	0.3	-0.3	-0.5	0.2	-0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.9	-1.4	-0.5	0.3	-1.2	0.8
Ulcerative Colitis	0.7	1.0	1.7	0.6	-1.2	1.3	1.1	0.3
Blood Eosinophil Count	0.3	2.0	3.0	-0.5	-1.6	1.5	-1.7	1.4
Blood Platelet Count	0.3	3.7	13.4	-2.0	-0.6	-0.5	-3.7	-0.6
Blood Red Count	0.6	6.1	13.6	-0.3	-3.7	1.8	-3.6	0.5
Blood White Count	0.8	6.0	19.9	-1.7	-2.4	1.0	-4.5	0.5
Heel T-Score	1.4	11.1	27.0	-3.4	2.3	-1.3	-5.2	-3.1
BMI	0.9	5.4	17.7	-2.6	-0.5	-1.3	-4.2	-0.7
Height	1.6	29.9	108.2	-3.0	0.5	-5.6	10.4	-0.6
Waist Hip Ratio (WHR)	0.9	3.8	10.0	-2.1	3.2	-1.8	-0.4	-1.1
Systolic Blood Pressure	1.5	7.5	14.8	-3.9	-0.6	0.3	-2.9	-3.7
Smoking Status	0.7	1.6	3.3	-0.2	1.8	-1.8	0.6	1.0
Allergy or Eczema	1.1	2.8	5.0	-0.9	1.0	-2.2	-2.2	-1.6
Cardiovascular Disease	1.9	6.2	16.2	-0.3	-3.2	1.8	-4.0	-1.0
Hypothyroidism (self reported)	0.6	1.4	3.6	1.6	0.1	0.6	1.9	0.4
Respiratory disease	0.8	1.9	6.7	-0.4	0.6	-0.0	-2.6	-1.5
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.7	-0.8	-1.0	-0.1	-2.2	-2.0
Lung FEV1/FVC ratio	0.9	4.5	10.8	-1.7	0.0	-2.6	-3.3	-1.4
Lung FVC	0.4	2.2	5.5	-1.6	-0.3	-1.7	-0.4	-2.4
Neuroticism	0.5	1.2	3.0	-1.7	-0.4	1.4	0.9	-0.1
Chronotype (morning person)	10.1	23.4	26.8	4.9	-5.2	5.2	3.6	5.1
Hair Pigment	0.1	4.2	9.5	-1.5	2.9	-3.1	-0.6	-0.7
Tanning	0.0	0.6	2.1	0.4	-0.2	0.5	1.4	0.5
Hand grip strength (left)	1.1	2.9	6.2	-2.0	-0.1	-1.6	-1.2	-2.5
Number of treatments/medications taken	0.5	0.9	1.9	-1.1	0.0	0.7	-1.4	-0.7
Average weekly spirits intake	0.5	0.6	2.2	-1.5	0.1	-0.0	-0.6	-0.5
Sensitivity / hurt feelings	1.5	2.6	5.2	1.4	-0.9	1.3	2.3	1.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.8	-1.4	-0.7	-0.8	-0.9	-0.8
Hearing difficulty/problems: Yes	0.2	0.4	0.9	-0.1	0.8	-0.9	0.4	-0.2
Relative age of first facial hair	1.6	3.2	8.7	-0.6	3.0	-1.4	-0.4	-2.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	2.9	-0.8	0.5	-1.6	-1.7	-1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.4	1.3	1.1	0.3	0.1	-0.6	-0.7
Ever had hysterectomy (womb removed)	1.9	2.1	6.3	0.8	2.5	0.4	0.3	-1.8
Systolic blood pressure, automated reading	1.2	3.6	14.1	-3.8	-0.4	0.6	-1.2	-1.4
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.2	0.6	-2.0	0.6	-1.6	-0.6
Angina	0.9	1.2	3.1	-0.3	1.7	-0.3	-1.3	-1.1
Medication for hormone replacement therapy	0.5	0.6	1.9	0.2	0.4	-0.4	-0.9	-1.4
Vitamin and mineral supplements	3.6	4.9	10.3	0.5	-3.2	3.0	0.3	2.2
Supplements: Zinc	0.5	0.6	1.0	-0.7	1.0	-0.9	-0.0	-0.6
Medication: Co-codamol	0.6	0.7	2.0	-1.4	0.6	-0.4	-1.0	0.0
Medication: Metformin	0.2	0.3	0.4	0.5	-0.5	0.6	0.7	0.2
Diabetes (father)	0.6	0.7	1.9	0.3	0.6	-1.4	-0.3	-1.1
Diabetes (mother)	0.3	0.3	1.2	-0.5	-0.1	1.1	0.2	0.4
Severe depression (siblings)	0.6	0.6	2.4	-0.3	0.8	-0.1	0.1	-1.6
Pack years adult smoking proportion	3.4	5.2	12.5	-0.9	-2.3	2.1	1.6	3.5
Impedance of leg (right)	0.6	2.7	10.5	1.0	-0.2	3.2	1.3	0.7
Leg fat-free mass (left)	1.3	6.7	17.4	-3.6	-0.0	-4.2	1.2	-1.3
Trunk fat percentage	1.0	3.9	15.5	-3.9	1.1	-0.9	-1.3	-0.7
Hand grip strength (right)	1.7	4.7	12.6	-2.5	-0.4	-2.0	-0.9	-3.5
Townsend deprivation index at recruitment	1.3	1.9	5.2	-2.3	0.3	-1.1	-1.2	-1.2
Current tobacco smoking	0.9	1.4	3.6	0.8	0.6	0.5	1.9	1.5
Average weekly fortified wine intake	2.2	2.5	5.8	0.4	-1.0	2.4	2.1	1.2
Maternal smoking around birth	1.6	2.3	5.0	0.7	-2.2	2.1	-0.3	1.3
Fed-up feelings	1.7	3.0	9.1	-3.0	-0.6	-0.2	-1.9	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	3.1	-1.8	-0.8	-0.6	-1.3	-0.7
Relative age voice broke	3.3	5.0	10.1	0.1	2.7	-2.2	-1.6	-3.2
Taking other prescription medications	0.5	0.7	2.4	-0.4	0.3	1.0	-1.6	-0.2
Age when periods started (menarche)	0.3	0.8	1.8	-1.3	-0.2	-0.8	-0.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.0	1.0	0.3	0.3	0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	6.5	-2.6	0.8	0.2	-2.0	-0.8
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	7.0	-1.8	2.6	-1.0	-1.5	-1.7
Qualifications: CSEs or equivalent	1.1	1.4	5.5	-2.4	-0.6	-0.8	-0.8	-0.2
Serious illness, injury or assault to yourself	1.2	1.5	3.8	-0.4	2.0	-1.3	-1.0	-0.8
High blood pressure	0.8	2.3	5.9	-1.2	-1.6	1.1	-2.4	-0.7
Hayfever, allergic rhinitis or eczema	1.1	2.4	4.6	-0.8	0.9	-2.1	-2.1	-1.2
Multivitamins +/- minerals	1.9	2.4	4.5	-1.1	2.1	-1.6	-0.2	-1.9
Stomach or abdominal pain in last month	0.4	0.5	0.7	-0.9	0.5	0.8	-0.4	-0.8
Supplements: Glucosamine	0.3	0.4	0.9	-0.4	0.6	-0.9	-0.4	-0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.2	0.3	0.5	0.3	-0.1
Medication: Atenolol	0.4	0.4	1.0	-0.5	0.5	0.3	-1.0	-0.8
Medication: Levothyroxine sodium	0.2	0.4	0.9	0.7	0.7	-0.1	0.9	0.5
Sitting height	0.6	4.5	12.0	-1.2	-3.5	-0.8	2.8	-0.9
Chronic bronchitis/emphysema (father)	1.0	1.2	4.0	0.3	0.3	0.7	1.2	2.0
High blood pressure (mother)	0.9	1.3	2.9	-1.3	-0.8	0.1	-1.7	-1.1
Body mass index (BMI)	1.2	5.1	15.1	-3.9	0.3	-1.6	-2.8	-0.0
Impedance of leg (left)	0.4	1.8	7.8	0.7	0.2	2.8	0.9	0.1
Leg predicted mass (left)	1.3	6.8	17.7	-3.6	0.0	-4.2	1.2	-1.3
Trunk fat mass	1.0	4.2	17.2	-4.1	0.8	-1.7	-0.5	-0.7
Waist circumference	1.0	3.6	14.0	-3.7	1.0	-1.7	-0.4	0.2
Number of incorrect matches in round	0.6	1.1	4.3	-0.6	0.3	-2.1	-0.5	0.5
Past tobacco smoking	0.3	0.5	1.0	0.6	-1.0	0.8	0.1	-0.7
Alcohol usually taken with meals	1.6	2.5	11.0	3.3	-1.0	0.0	-0.6	-0.5
Nervous feelings	2.7	5.0	9.8	-1.6	-2.0	3.1	2.1	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.2	-1.5	-0.1	-0.8	-0.4	-1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.6	-1.3	0.6	-0.9	0.4	-0.4
Hair/balding pattern: Pattern 2	1.5	1.9	3.6	1.6	-1.9	0.8	0.2	1.7
Had menopause	0.9	1.2	2.5	1.6	0.1	0.9	1.1	1.1
Had other major operations	0.6	0.7	1.9	-0.6	-0.8	-0.7	-1.4	-0.6
Forced vital capacity (FVC)	0.8	3.1	6.4	-1.2	-0.9	-1.4	2.1	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	6.6	-2.4	1.1	-0.2	-2.6	-1.4
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	7.3	-1.3	0.3	-0.3	-2.7	-2.1
Qualifications: None of the above	0.4	0.9	1.5	-1.2	-1.1	-0.8	-0.4	1.0
Financial difficulties in last 2 years	2.1	2.8	4.6	-1.9	1.1	-1.3	-2.1	-1.7
Mouth/teeth dental problems	2.3	3.5	12.0	3.5	1.0	-0.1	-1.2	-1.8
Heart attack	1.2	1.6	3.1	-1.4	1.6	-0.5	-1.8	-0.4
Allergy	0.9	2.0	6.8	0.1	0.1	1.4	2.6	1.1
Pain all over the body in last month	0.3	0.4	0.9	-0.6	-0.4	0.5	-0.9	-0.4
Diabetes (self-reported)	0.5	0.8	2.7	0.2	-1.7	1.1	-0.3	-0.0
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.0	-1.0	1.4	-0.9	-1.0	-0.3
Medication: Ramipril	0.4	0.5	1.1	0.6	0.8	0.2	-1.1	-0.5
Medication: Simvastatin	0.4	0.5	1.8	-0.2	-0.5	0.7	-1.3	-0.1
Fluid intelligence score	3.1	6.5	11.5	2.1	-1.7	3.3	3.4	1.5
Illnesses of siblings	1.6	2.2	7.0	0.9	-0.7	-0.5	2.6	1.6
Neuroticism score	0.5	1.0	2.9	-1.7	-0.5	1.0	0.8	-0.4
Weight	1.1	5.4	18.0	-4.2	0.2	-2.9	0.3	-0.8
Impedance of arm (right)	0.8	3.8	9.4	3.1	0.9	1.7	2.4	0.0
Arm fat percentage (right)	0.8	3.0	10.3	-3.2	0.3	-0.9	-2.0	0.1
Trunk fat-free mass	1.0	5.9	15.4	-2.9	-0.7	-3.9	2.1	-1.1
Hip circumference	0.6	2.8	11.8	-3.4	-0.4	-1.3	-0.2	-0.4
Time employed in main current job	1.2	1.3	3.6	0.3	-0.8	1.9	0.3	1.5
Alcohol intake versus 10 years previously	0.5	0.8	2.4	-0.3	0.1	1.0	-1.6	-0.6
Father’s age at death	0.8	1.1	2.0	1.4	1.3	0.3	1.0	-0.7
Worrier / anxious feelings	3.6	6.8	10.0	0.2	-3.1	3.2	2.5	2.8
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	10.3	-3.2	0.3	-0.5	-1.3	-1.4
Falls in the last year	0.5	0.7	2.1	-1.5	-0.1	-1.1	-0.4	-0.3
Hair/balding pattern: Pattern 3	3.1	4.6	10.2	-2.0	3.2	-2.2	1.2	-1.5
Number of live births	0.1	0.1	0.6	-0.1	0.2	0.3	0.8	-0.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	9.1	-1.8	-1.0	-2.2	0.5	-3.0
Pulse rate	0.9	1.5	2.9	-0.3	1.0	-1.0	-1.6	-1.7
Happiness	0.6	0.7	2.8	-1.7	-0.3	-0.1	-0.6	-0.5
Noisy workplace	1.3	1.7	6.2	-2.5	0.7	-1.1	-0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	0.8	-0.5	0.1	1.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	8.8	0.1	0.7	-3.0	-0.6	-0.6
Mouth/teeth dental problems: Dentures	1.1	1.8	6.0	-2.4	-1.5	0.2	-0.4	0.7
Asthma	1.2	2.4	8.0	-0.6	1.3	0.4	-2.8	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.7	-1.1	-0.2	0.3	-0.3
Medication: Cholesterol lowering	1.0	1.6	4.8	-2.2	-0.2	0.1	-1.6	-0.7
Depression (self-reported)	1.5	1.7	5.5	-0.4	0.1	0.1	-1.7	-2.3
Medication: Lansoprazole	0.4	0.4	1.0	0.6	-0.6	0.6	-0.0	1.0
Prospective memory result	0.4	0.5	2.0	-0.5	0.2	-0.4	-1.4	-0.0
Lung cancer (father)	2.0	2.4	6.7	-0.1	1.6	-0.8	2.6	1.4
Illnesses of mother	1.5	1.9	3.9	0.7	-2.0	1.2	1.4	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	9.0	-1.8	-1.2	-2.4	-0.0	-3.0
Pulse wave Arterial Stiffness index	1.0	1.1	3.0	-0.9	-0.4	0.3	1.7	1.3
Impedance of arm (left)	0.7	3.4	7.5	2.7	0.8	2.2	2.0	-0.2
Arm fat mass (right)	1.0	4.1	14.3	-3.8	-0.1	-1.8	-1.6	-0.6
Trunk predicted mass	1.0	5.9	15.4	-2.9	-0.7	-3.9	1.9	-1.2
Standing height	1.1	11.3	39.8	-1.2	-0.5	-3.4	6.3	-1.8
Length of working week for main job	0.8	0.9	2.1	1.5	0.6	-1.2	0.0	0.6
Exposure to tobacco smoke at home	0.7	0.8	2.3	0.6	-0.9	0.4	-0.5	1.5
Breastfed as a baby	3.6	4.5	6.1	-2.5	2.3	-2.4	-0.8	-2.2
Tense / ‘highly strung’	0.5	0.8	1.6	-0.8	-0.7	0.4	-1.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	4.5	6.9	12.0	-2.9	0.9	-2.0	-3.0	-3.5
Hair/balding pattern: Pattern 4	0.5	1.3	3.9	1.1	-0.9	0.5	-0.6	-2.0
Birth weight of first child	0.3	0.5	1.5	-0.6	0.3	0.4	-0.6	-1.2
Peak expiratory flow (PEF)	1.1	2.7	12.5	-0.3	-3.5	0.7	0.1	-0.4
Pulse wave reflection index	1.5	1.8	3.9	0.5	-1.8	0.8	1.2	2.0
Ever highly irritable/argumentative for 2 days	0.6	0.8	3.1	-1.8	-0.5	0.2	0.6	0.0
Loud music exposure frequency	2.0	2.2	5.8	-0.7	2.1	-2.4	-0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.3	0.9	0.2	-0.0	1.1	-0.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.3	-1.8	-0.0	-0.3	-0.8	0.6
Blood clot in the leg (DVT)	1.5	2.0	5.3	0.4	0.5	-2.3	-0.4	-2.0
Medication: Paracetamol	0.5	0.8	2.0	-0.9	-0.6	-0.1	-1.4	-0.9
Headache pain in last month	2.0	3.4	7.1	-1.2	1.1	-0.8	-2.7	-2.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	3.7	1.8	1.6	-1.6	1.9	0.6
Glaucoma (self-reported)	3.6	4.2	7.5	-0.5	2.2	-1.9	-2.2	-2.7
Gout (self-reported)	0.9	1.2	1.9	0.8	-1.1	1.4	1.0	1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.1	0.4	0.6	-0.2	1.8	0.3
Medication: Amlodipine	0.3	0.5	1.0	0.0	0.5	0.5	-0.9	-1.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.5	-0.2	-0.1	0.6	1.1	1.9
Birth weight	1.4	3.0	5.8	-1.9	2.4	-2.3	0.2	-0.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.5	-0.5	-1.2	0.8	0.7	1.9
High blood pressure (siblings)	1.9	2.7	8.0	0.7	-1.0	0.8	-2.8	-1.9
Forced vital capacity (FVC), Best measure	1.0	3.7	9.8	-1.6	-0.9	-2.0	1.1	-3.1
Body fat percentage	1.1	4.3	17.0	-4.1	0.8	-0.5	-1.8	-0.4
Leg fat percentage (right)	1.1	3.8	14.9	-3.9	0.2	0.2	-1.9	0.8
Arm fat-free mass (right)	1.3	6.9	17.3	-4.2	-0.3	-3.7	0.8	-1.6
Exposure to tobacco smoke outside home	0.9	1.2	2.3	0.7	-1.4	0.7	-1.0	1.5
Comparative body size at age 10	0.5	1.3	2.3	0.1	1.4	-0.3	1.5	1.4
Number of full brothers	0.9	1.2	2.5	-0.7	0.4	-1.6	-0.9	-1.4
Worry too long after embarrassment	1.7	2.8	10.7	-0.3	1.3	0.5	3.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.4	-1.5	0.0	-1.7	-1.4	-1.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.2	0.7	0.2	-0.9	0.6
Number of children fathered	0.4	0.5	1.3	-0.1	0.8	-1.1	-0.5	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.8	1.5	1.0	0.4	2.0	0.3
Age at first live birth	0.2	0.3	0.5	0.2	-0.5	0.5	-0.6	-0.7
Pulse wave peak to peak time	0.6	0.7	1.7	0.6	0.1	-0.6	-1.1	-1.3
Health satisfaction	2.3	3.0	9.3	-3.1	0.7	-1.8	-1.2	-0.6
Shortness of breath walking on level ground	1.3	1.6	4.8	-2.2	0.5	-1.2	-1.2	0.0
Qualifications: College or University degree	0.9	2.9	6.4	2.5	1.6	-0.3	2.2	-1.0
Eye problems/disorders: None of the above	2.8	3.2	8.0	0.6	-1.3	1.8	2.8	1.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.0	-1.7	0.1	0.2	1.6	0.9
Emphysema/chronic bronchitis	0.7	0.8	2.5	-0.5	-1.6	-0.1	-1.0	-0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	2.7	0.1	1.6	-1.2	0.6	-0.5
Neck or shoulder pain in last month	0.4	0.5	2.3	-0.1	1.5	-0.5	0.0	0.1
Medication: Blood pressure	0.9	1.6	2.8	-1.5	-0.3	1.1	-1.7	-1.2
Angina (self-reported)	1.3	1.8	4.0	-0.4	2.0	-0.8	-1.5	-1.3
Migraine (self-reported)	0.2	0.3	0.4	0.2	-0.7	0.7	-0.5	0.3
Medication: Ibuprofen	0.3	0.3	1.1	1.1	-0.4	-0.4	-0.2	-0.5
Medication: Allopurinol	0.7	0.9	2.0	0.5	-1.4	0.9	0.8	0.9
Medication: Omeprazole	0.3	0.4	0.8	-0.9	0.1	-0.3	-0.7	0.6
Medication: Seretide 50 evohaler	1.1	1.2	2.1	-0.2	1.3	-0.6	-1.4	-1.4
Mean time to correctly identify matches	3.2	6.0	15.1	0.4	3.9	-3.6	1.1	-1.0
Heart disease (mother)	1.6	1.9	4.3	0.2	1.2	-1.4	-2.1	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.2	-0.8	1.8	-0.1	0.4	0.2
Whole body fat mass	1.2	4.8	19.4	-4.4	0.6	-1.7	-1.0	-0.7
Leg fat mass (right)	1.4	5.3	22.4	-4.7	0.3	-1.5	-1.3	-0.2
Arm predicted mass (right)	1.5	7.4	18.1	-4.2	-0.0	-3.9	0.5	-2.0
Pulse rate, automated reading	1.0	3.2	6.7	-2.6	0.5	0.4	-1.9	-2.2
Alcohol intake frequency.	0.3	0.6	1.3	-0.0	0.4	-0.7	-1.1	-1.0
Comparative height size at age 10	1.1	6.0	24.6	-1.5	-0.6	-1.5	5.0	0.5
Number of full sisters	1.3	1.6	5.5	-2.3	-0.3	-0.5	-1.2	-0.6
Suffer from ‘nerves’	1.9	3.0	5.1	-2.0	-2.2	2.3	0.7	0.9
Overall health rating	1.1	2.3	5.3	-2.3	0.2	1.0	-1.9	-1.2
Chest pain or discomfort	1.8	2.6	5.6	-2.4	1.8	-0.9	-1.6	-0.8
Had major operations	0.7	0.8	2.3	-0.3	-0.2	0.8	1.0	1.5
Age at last live birth	1.3	1.9	5.9	-0.5	-2.4	1.9	0.2	-0.1
Family relationship satisfaction	0.8	1.0	1.8	-0.6	-1.2	0.6	0.9	1.3
Leg pain on walking	0.6	0.7	1.7	-1.1	0.7	-1.3	0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	5.4	-2.3	0.9	-0.9	-0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.0	-1.7	0.4	-0.9	0.0	0.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	5.2	2.3	-0.4	1.1	2.0	0.7
Medication: Aspirin	2.2	2.9	8.0	0.6	-1.9	2.8	-0.1	1.5
Supplements: Vitamin C	1.5	1.8	4.7	0.5	2.2	-1.9	-0.3	-0.7
Knee pain experienced in last month	1.1	1.6	5.1	-2.3	-1.0	1.2	-0.4	0.8
Hypertension (Self-reported)	0.9	2.4	6.6	-1.3	-1.5	0.9	-2.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.4	-2.5	-0.9	1.3	-1.3	0.3
Illnesses of father: Heart disease	0.6	0.8	3.0	0.7	0.6	-0.3	-1.7	-0.6
Illnesses of siblings: Diabetes	0.6	0.7	1.4	-1.2	0.6	-0.3	-1.2	-0.7
Smoking status: Previous	0.6	0.9	2.4	-1.1	0.7	-1.5	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	9.5	-1.4	0.9	-3.1	1.3	-1.6
Whole body fat-free mass	1.3	7.2	18.4	-3.6	-0.2	-4.3	1.5	-1.5
Leg fat-free mass (right)	1.4	7.5	20.9	-3.5	0.3	-4.6	1.1	-1.7
Arm fat percentage (left)	0.8	3.3	11.5	-3.4	0.4	-0.7	-2.1	-0.1
Average weekly red wine intake	0.5	0.7	2.4	1.6	-0.6	-0.6	0.7	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	1.4	0.2	-0.4	0.2	1.2
Mood swings	0.5	0.9	1.3	-1.0	-0.9	-0.3	-1.1	-1.2
Loneliness, isolation	0.7	0.9	2.6	-1.6	-0.6	0.1	-1.2	-0.4
Long-standing illness, disability or infirmity	1.9	3.0	8.5	-1.3	0.7	-0.5	-2.9	-2.0
Ever had bowel cancer screening	1.3	1.5	3.2	1.2	0.2	1.5	1.8	0.9
Diabetes diagnosed by doctor	0.4	0.7	1.4	0.3	-1.2	0.8	-0.5	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.2	-0.7	1.4	-1.5	-0.4	-1.4
Friendships satisfaction	0.3	0.4	1.3	-0.6	-1.1	0.2	0.4	0.3
Qualifications: nursing, teaching	0.6	0.9	1.7	0.8	-0.5	1.0	1.3	1.1
Commuting to job workplace: Walk	0.7	0.8	2.5	-0.4	-0.1	-0.5	-1.1	-1.6
Eye problems/disorders: Cataract	0.6	0.7	1.4	-0.8	1.2	-1.2	-0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	9.5	0.3	0.3	0.3	3.1	1.7
Medication for cholesterol	1.9	2.9	10.6	-0.3	1.2	-0.5	3.3	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	5.9	-2.1	2.4	-2.1	-0.1	-1.6
Back pain experienced in last month	2.0	3.0	6.0	-0.5	1.4	-1.9	-2.4	-1.7
Mineral and other dietary supplements	1.0	1.3	3.4	0.7	-1.5	1.9	0.2	0.3
Breast cancer (self-reported)	1.8	2.2	4.8	0.9	-1.8	0.5	1.3	2.2
Asthma (self-reported)	1.2	2.3	8.0	-0.3	1.3	0.3	-2.8	-1.4
Osteoporosis (self-reported)	0.1	0.2	0.4	-0.6	0.5	-0.3	0.2	0.2
Osteoarthritis (self-reported)	0.5	0.6	1.5	-1.2	0.9	0.5	-0.7	0.1
Medication: Aspirin	2.5	3.2	8.1	0.9	-2.2	2.8	0.0	1.5
Medication: Gliclazide	0.2	0.2	0.6	0.2	-0.2	-0.1	-0.5	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.7	-0.4	-0.0	-0.1	-0.8
Smoking status: Current	1.2	1.8	3.6	1.3	0.4	1.0	1.9	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	8.6	-0.8	-0.8	-0.6	-1.3	-2.9
Whole body water mass	1.2	7.0	17.9	-3.5	-0.3	-4.2	1.4	-1.5
Leg predicted mass (right)	1.4	7.5	20.8	-3.6	0.3	-4.6	1.0	-1.8
Arm fat mass (left)	1.1	4.5	15.5	-3.9	0.3	-1.9	-1.6	-0.8
Number of self-reported non-cancer illnesses	0.8	1.4	4.2	-1.2	0.6	-0.8	-2.1	-0.2
Average weekly champagne plus white wine intake	1.9	2.6	8.5	2.9	-1.5	1.2	-0.6	-0.7
Miserableness	2.5	4.4	7.8	-2.1	2.2	-2.1	-0.8	-2.8
Guilty feelings	0.9	1.3	2.7	-0.8	1.6	-0.7	1.6	0.1
Wears glasses or contact lenses	1.2	1.4	5.2	1.1	0.2	2.3	0.5	0.6
Ever taken oral contraceptive pill	2.8	3.2	8.3	-0.2	1.5	-2.9	-0.9	-2.1
Hearing aid user	0.9	1.0	1.6	-1.3	0.8	-1.0	-1.1	-0.8
Mother’s age at death	2.1	2.6	8.2	2.9	0.2	1.4	1.4	1.0
Financial situation satisfaction	1.2	1.5	3.2	-1.7	-0.3	0.0	-1.8	-1.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	0.1	0.2	-1.0	0.3	-0.7
Commuting to job workplace: Public transport	1.4	1.7	4.1	2.0	-1.0	1.4	0.3	-1.2
Eye problems/disorders: Glaucoma	2.2	2.6	4.4	-0.0	1.9	-1.4	-2.1	-1.7
Medication: Blood pressure	1.4	2.6	7.7	-1.2	-1.5	0.9	-2.8	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	-1.2	-0.5	0.5	-0.7	0.4
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.6	-1.5	1.9	-1.6	-0.1	-0.8
High cholesterol (Self-reported)	0.8	1.4	4.1	0.5	-1.2	0.9	-2.0	-0.5
Medication: Bendroflumethiazide	0.6	0.9	2.5	-1.6	-0.3	1.0	-0.8	-0.7
Medication: Paracetamol	1.3	2.0	3.4	-1.7	0.5	-1.1	-1.4	-1.8
Medication: Lisinopril	0.7	0.9	2.6	-0.7	-1.6	0.8	-0.3	0.7
Medication: Atorvastatin	0.8	1.0	1.6	0.1	-1.1	1.3	-1.2	0.7
Illnesses of father: High blood pressure	0.3	0.4	0.9	0.7	-0.1	-0.1	-0.9	-0.8
Alcohol drinker status: Never	0.7	0.8	2.2	0.5	1.5	-0.9	0.7	-0.5
Ever smoked	0.7	1.2	2.7	0.3	1.7	-1.6	-0.6	-0.1
Basal metabolic rate	1.3	6.9	15.7	-4.0	-0.3	-3.9	1.1	-1.4
Leg fat percentage (left)	1.2	4.3	15.9	-4.0	0.4	-0.1	-2.2	0.6
Arm fat-free mass (left)	1.5	7.7	17.9	-4.2	-0.1	-4.1	0.3	-2.0
Number of operations (self-reported)	0.1	0.2	0.4	0.2	0.5	0.3	-0.0	0.6
Average weekly beer plus cider intake	2.2	3.2	12.1	-3.5	0.8	-1.0	-1.1	-0.9
Irritability	0.7	1.1	2.7	-0.1	0.6	1.6	1.6	-0.4
Risk taking	2.9	4.2	10.6	-1.1	2.8	-3.2	-0.6	-1.1
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.0	0.6	-1.7	1.7	0.3	1.7
Fractured/broken bones in last 5 years	0.2	0.2	0.6	-0.6	0.3	-0.8	0.2	0.2
Age started oral contraceptive pill	1.3	1.6	3.6	1.5	1.3	0.0	-0.6	-1.9
Diastolic blood pressure, automated reading	1.2	3.7	8.6	-2.9	-2.1	2.2	0.2	-0.3
Ever depressed for a whole week	0.5	0.6	1.1	-0.8	-0.1	0.2	-1.0	-1.1
Unable to work because of sickness or disability	2.3	3.0	4.3	-1.4	2.1	-1.2	-1.9	-1.9
Commuting to job workplace: Cycle	0.4	0.5	1.7	1.3	-0.5	0.1	0.7	0.2
Myopia	0.1	0.2	0.4	-0.3	0.4	-0.3	0.6	-0.4
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.8	1.0	1.4	-1.1	2.4	0.3
Cholesterol lowering medication	2.2	3.2	8.1	2.9	-0.8	1.6	-2.2	0.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	-0.9	-1.0	0.8	-0.3	1.6
Pain experienced in last month	0.5	0.8	1.5	1.2	-0.0	-1.1	1.1	-0.3
Supplements: Calcium	1.0	1.1	4.3	2.1	0.3	-0.9	0.0	-0.6
Basal cell carcinoma (self-reported)	0.4	0.4	1.4	0.3	0.2	-1.2	0.7	0.4
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.6	-1.5	1.9	-0.6	-1.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	6.2	-0.0	0.9	-2.5	-0.6	-2.1
Heart disease (siblings)	0.9	1.1	3.8	-0.9	1.9	-0.6	-0.5	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.2	0.4	-0.1	0.3	0.3	-0.3
Pack years of smoking	3.6	5.2	14.0	-0.8	-2.2	2.0	1.6	3.7
Impedance of whole body	0.6	3.0	8.2	2.1	0.4	2.9	1.4	-0.1
Leg fat mass (left)	1.3	5.2	20.8	-4.6	0.3	-1.6	-1.5	-0.3
Arm predicted mass (left)	1.6	7.9	18.7	-4.3	-0.1	-4.1	0.3	-1.9