Hub : Genes

TBC1D5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0662	0.0332	6.5e-03	-0.003	NA	-0.002	NA	-0.004	6.7e-01	NA	0.48000	NA	9.2e-01
2	GTEx	Testis	0.1380	0.0600	2.8e-03	0.115	NA	0.050	NA	0.124	8.6e-06	NA	0.00280	NA	4.0e-06
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.1973	0.0719	8.6e-05	0.014	0.029	0.030	NA	0.020	9.1e-03	0.0003	0.00023	NA	2.0e-03
4	TCGA	Prostate Adenocarcinoma	0.0208	0.0150	6.3e-03	0.021	0.018	0.012	NA	0.013	2.5e-03	0.0051	0.01700	NA	1.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.7	2.8	5.4	2.3	-0.4	2.1	1.0
Bipolar Disorder or Schizophrenia	1.1	2.7	5.8	-1.2	1.6	1.1	-2.4
Depressed Affect (Nagel 2018)	1.2	2.6	8.6	2.9	-1.3	-0.1	0.4
Depression (Nagel 2018)	1.3	2.0	5.0	-0.1	0.3	-1.7	-2.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.6	0.2	-1.3	0.2	0.3
Neuroticism (Nagel 2018)	1.3	3.0	9.6	3.1	-1.3	-0.2	0.9
Schizophrenia (2018)	3.8	7.9	15.3	-3.3	2.3	-0.3	-3.9
Schizophrenia vs Biploar Disorder	8.2	10.8	24.4	-3.5	0.5	-2.5	-4.9
Worry (Nagel 2018)	0.6	1.2	2.5	1.6	0.1	-1.1	1.1
Alzheimer’s Disease (in mother)	1.5	1.7	4.5	0.8	-2.1	0.7	-1.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.4
Alzheimer’s Disease (including proxy)	0.8	1.2	3.2	0.3	-1.8	-0.1	-1.3
Crohns Disease (2017)	1.6	3.5	7.7	-2.1	2.8	-0.1	-1.3
Irritable Bowel Disease (IBD)	1.1	2.6	7.2	-1.4	2.7	-0.4	-1.0
Ulcerative Colitis (UC)	0.9	1.7	4.4	-0.9	2.1	-1.1	-0.6
Major Depression (MDD)	0.4	0.4	1.5	-1.2	0.3	-0.1	0.5
Reaction Time	0.3	0.6	2.2	0.4	0.3	-0.2	1.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	0.3	-1.0	0.2	0.1
Breast Cancer	0.3	0.8	2.1	1.0	0.0	0.2	1.4
Ovarian Cancer	0.5	0.6	1.2	-1.0	1.1	-0.2	-0.5
Prostate Cancer	0.7	1.0	3.0	0.1	0.8	1.7	-0.7
Age at First Birth	0.5	0.7	2.6	-0.2	0.0	0.1	1.6
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.1	0.8	-0.0	0.3
Body Mass Index (BMI) (2010)	0.5	0.7	2.3	-0.3	-1.5	0.5	0.4
Coronary Artery Disease (CAD)	0.8	0.9	1.8	-1.4	0.7	-0.7	-0.9
Crohns Disease (2012)	0.7	1.2	2.3	-1.2	0.8	0.4	-1.5
Mean Putamen Volume	0.3	0.4	0.8	0.9	-0.5	0.6	0.4
Fasting Glucose	1.1	1.3	3.8	2.0	-0.6	0.0	1.1
HbA1C	0.9	1.0	2.5	0.6	-1.6	0.0	1.1
HDL Cholesterol	0.2	0.4	1.3	0.0	-0.4	1.1	0.1
LDL Cholesterol	0.2	0.4	0.7	0.7	0.3	0.2	0.9
Lupus	2.4	3.6	5.3	-1.8	1.8	-1.6	-2.3
Neuroticism (2016)	0.2	0.3	0.4	-0.3	0.6	-0.6	-0.5
Primary Biliary Cirrhosis	0.4	0.6	1.0	0.6	0.1	1.0	-1.0
Rheumatoid Arthritis	0.6	0.9	1.6	-1.1	0.5	0.7	-1.3
Schizophrenia (2014)	2.8	6.2	13.2	-2.5	2.2	-0.4	-3.6
Triglycerides	0.3	0.5	1.3	-1.1	-0.1	-0.0	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	-0.0	-0.1	-0.9	0.8
Ulcerative Colitis	1.5	2.1	4.5	-0.9	2.1	-1.6	-0.8
Blood Eosinophil Count	0.2	1.3	4.5	-0.7	0.3	0.0	2.1
Blood Platelet Count	0.4	4.1	6.2	-2.1	0.2	2.4	2.5
Blood Red Count	0.5	4.6	10.2	-2.7	0.0	-0.9	-3.2
Blood White Count	0.8	6.3	10.4	-3.2	0.9	-2.2	-3.0
Heel T-Score	0.1	0.8	2.6	-1.6	0.2	-0.1	-0.6
BMI	0.9	5.4	10.1	1.7	-2.0	2.2	3.2
Height	0.4	8.6	31.1	1.5	-1.0	-0.4	5.6
Waist Hip Ratio (WHR)	0.3	1.6	3.4	0.8	0.2	1.5	-1.9
Systolic Blood Pressure	0.1	0.4	0.9	-0.7	-0.2	-0.9	-0.6
Smoking Status	1.1	2.7	6.9	1.2	-0.2	1.5	-2.6
Allergy or Eczema	1.6	4.3	9.5	1.2	-3.1	1.4	2.0
Cardiovascular Disease	0.6	2.1	5.6	-2.4	1.4	-0.3	0.9
Hypothyroidism (self reported)	0.9	2.0	4.0	-0.9	-1.4	-1.1	2.0
Respiratory disease	0.8	1.8	4.2	1.3	-1.0	2.0	0.7
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.1	0.5	0.9	2.2	2.1
Lung FEV1/FVC ratio	0.5	2.5	4.3	-2.1	0.5	-1.5	-1.8
Lung FVC	0.3	1.4	3.3	-1.0	-1.1	-1.8	-0.6
Neuroticism	0.7	1.7	3.6	1.9	-1.7	-0.8	-0.0
Chronotype (morning person)	1.0	2.4	5.4	1.0	1.6	0.9	-2.3
Hair Pigment	0.1	3.9	7.1	-2.7	1.6	-0.8	-2.3
Tanning	0.2	2.1	5.9	-1.5	-0.2	-0.4	-2.4
Hand grip strength (left)	1.2	3.1	8.4	-0.1	-2.9	1.5	-1.3
Number of treatments/medications taken	1.6	2.9	9.4	0.7	1.2	0.5	3.1
Average weekly spirits intake	1.1	1.4	3.3	1.3	-0.1	0.6	1.8
Sensitivity / hurt feelings	0.4	0.7	2.5	1.6	-0.5	-0.1	-0.3
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.5	-0.4	0.9	-1.8	-1.9
Hearing difficulty/problems: Yes	0.7	1.1	2.5	-0.9	0.2	-0.9	-1.6
Relative age of first facial hair	0.6	1.3	2.1	-1.4	1.0	-1.0	-1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.5	1.2	0.1	-0.9	0.3
Ever used hormone-replacement therapy (HRT)	1.7	2.2	3.7	1.4	0.6	1.9	1.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.5	0.2	-0.1	-0.1	0.7
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.2	-0.4	-0.3	-0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.5	-0.1	-0.3	1.6	0.0
Angina	0.4	0.5	1.4	0.9	-0.0	0.1	1.2
Medication for hormone replacement therapy	0.4	0.4	1.0	0.6	-0.4	0.3	-1.0
Vitamin and mineral supplements	0.3	0.4	1.5	0.2	-1.2	-0.4	0.1
Supplements: Zinc	5.9	6.4	13.2	-3.6	0.5	0.6	-3.4
Medication: Co-codamol	0.3	0.4	0.5	-0.7	-0.7	0.6	-0.0
Medication: Metformin	1.1	1.6	2.9	1.0	-0.2	1.7	1.5
Diabetes (father)	0.9	1.1	3.0	-0.7	0.8	0.6	1.7
Diabetes (mother)	0.8	1.0	2.4	0.6	-0.4	1.6	1.1
Severe depression (siblings)	1.6	1.8	4.3	-0.0	0.3	-2.1	1.7
Pack years adult smoking proportion	0.6	0.9	1.8	1.3	0.8	0.1	-1.2
Impedance of leg (right)	0.9	4.3	8.3	-1.0	2.9	-2.6	-1.0
Leg fat-free mass (left)	0.7	3.6	8.7	1.3	-1.9	0.7	2.9
Trunk fat percentage	0.5	2.2	6.6	1.4	0.2	0.5	2.6
Hand grip strength (right)	0.9	2.4	6.5	-0.2	-2.5	1.7	-0.6
Townsend deprivation index at recruitment	0.6	0.9	1.2	-0.7	1.0	-1.0	-1.1
Current tobacco smoking	1.4	2.4	7.5	0.8	1.1	0.2	-2.7
Average weekly fortified wine intake	0.5	0.6	1.6	-0.7	0.3	-0.3	1.3
Maternal smoking around birth	1.2	1.8	4.8	-0.1	2.2	-0.7	-1.3
Fed-up feelings	0.9	1.5	5.1	0.7	0.7	-0.2	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	8.0	-0.7	0.9	-0.6	-2.8
Relative age voice broke	0.1	0.2	0.5	0.3	0.4	0.2	0.7
Taking other prescription medications	0.9	1.4	4.5	1.1	-0.3	-0.0	2.1
Age when periods started (menarche)	0.2	0.5	1.2	-1.1	0.6	-0.7	-0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	-0.8	0.7	-1.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.6	1.2	-1.1	-0.3
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	3.4	-1.6	1.9	-1.3	-1.7
Qualifications: CSEs or equivalent	1.4	1.8	2.6	-1.6	1.3	-1.6	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.3	0.6	-0.5	-1.1	0.3
High blood pressure	0.8	2.1	6.3	-0.2	1.4	0.4	2.5
Hayfever, allergic rhinitis or eczema	2.6	5.6	9.7	1.9	-3.1	1.6	2.6
Multivitamins +/- minerals	0.2	0.2	0.6	-0.3	0.8	0.6	-0.1
Stomach or abdominal pain in last month	0.6	0.8	1.9	-0.8	1.4	-0.8	-0.0
Supplements: Glucosamine	0.2	0.3	0.8	-0.4	0.2	0.2	0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	-0.5	-0.7	-0.0	1.1
Medication: Atenolol	3.3	4.2	13.8	1.6	0.4	-0.6	3.7
Medication: Levothyroxine sodium	0.6	1.0	2.8	-0.7	-0.5	-0.6	1.7
Sitting height	0.1	0.7	1.6	0.5	0.3	-0.8	1.3
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.3	0.6	-0.0	-0.9
High blood pressure (mother)	1.8	2.5	7.0	0.3	-1.0	1.4	2.6
Body mass index (BMI)	0.7	2.8	5.1	1.0	-1.4	2.2	1.8
Impedance of leg (left)	0.9	4.3	9.4	-1.1	3.1	-2.3	-1.1
Leg predicted mass (left)	0.6	3.2	7.7	1.2	-1.9	0.6	2.8
Trunk fat mass	0.7	2.8	8.6	1.4	-0.3	0.8	2.9
Waist circumference	0.8	3.0	3.8	1.6	-1.3	1.9	2.0
Number of incorrect matches in round	3.2	5.3	10.6	-3.3	1.4	-1.1	-2.7
Past tobacco smoking	0.7	1.2	4.8	-0.3	0.3	-2.2	0.1
Alcohol usually taken with meals	0.4	0.7	1.5	0.7	-0.7	-1.2	0.6
Nervous feelings	0.3	0.6	1.1	0.3	0.7	-1.0	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	0.4	-0.6	-0.7	-1.3
Hearing difficulty/problems with background noise	0.7	1.2	3.4	0.5	0.4	-1.9	-1.0
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.9	-0.8	0.1	-0.1
Had menopause	2.7	3.4	7.6	1.2	0.3	2.1	2.8
Had other major operations	1.4	1.7	2.6	1.3	1.2	-1.6	0.9
Forced vital capacity (FVC)	0.2	0.8	1.6	-0.7	-1.3	-0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	0.9	0.6	0.9	-1.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.9	-1.3	-0.4	-0.2	-1.4
Qualifications: None of the above	1.2	2.6	9.3	-0.4	3.0	0.0	-0.9
Financial difficulties in last 2 years	0.3	0.4	0.9	-0.7	0.3	-0.4	-0.9
Mouth/teeth dental problems	0.5	0.8	1.7	0.2	-0.7	1.3	1.0
Heart attack	0.4	0.5	1.6	0.1	1.3	-0.3	0.6
Allergy	2.3	5.4	7.3	-2.7	2.6	-1.1	-2.5
Pain all over the body in last month	1.7	1.8	6.4	0.9	-0.3	2.5	-0.2
Diabetes (self-reported)	1.0	1.6	2.8	0.8	0.8	1.5	1.7
Hayfever/allergic rhinitis (self-reported)	6.1	8.1	10.4	3.1	-3.0	1.8	3.2
Medication: Ramipril	1.2	1.6	2.4	-0.9	1.5	-1.4	1.1
Medication: Simvastatin	0.5	0.8	1.6	0.4	0.5	1.0	1.3
Fluid intelligence score	0.2	0.4	1.3	-0.3	-0.5	1.1	0.3
Illnesses of siblings	1.0	1.4	3.1	0.6	-1.8	-1.2	-0.8
Neuroticism score	0.4	0.9	2.3	1.5	-0.1	-1.0	-0.4
Weight	0.7	3.5	8.7	1.2	-1.4	1.4	3.0
Impedance of arm (right)	0.6	2.6	6.7	-0.1	1.9	-2.6	-0.4
Arm fat percentage (right)	0.5	2.0	4.0	1.2	-0.6	1.5	2.0
Trunk fat-free mass	0.4	2.2	5.2	0.4	-1.7	0.6	2.3
Hip circumference	1.1	4.7	11.1	1.8	-1.8	1.2	3.3
Time employed in main current job	1.5	1.7	3.6	-1.7	-0.4	1.9	-0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.5	0.7	-0.3	-0.1
Father’s age at death	0.8	1.1	1.6	0.7	-0.8	1.3	1.3
Worrier / anxious feelings	1.4	2.7	6.0	2.1	0.3	0.3	2.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.8	0.4	-0.1	-0.6
Falls in the last year	0.4	0.6	0.8	0.9	-0.7	0.9	0.4
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	-0.1	-0.2	0.0	-0.4
Number of live births	1.3	1.8	5.2	0.4	0.8	1.0	2.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.2	-1.8	-1.0	-1.2	-0.8
Pulse rate	1.4	2.4	7.3	-1.5	-0.1	-0.2	-2.7
Happiness	1.6	1.9	6.0	-0.3	-1.2	-0.3	-2.4
Noisy workplace	3.5	4.3	11.4	-1.3	3.4	-0.3	-2.0
Qualifications: A levels/AS levels or equivalent	1.1	2.5	5.5	1.4	-2.3	0.5	1.5
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	7.3	1.1	-0.5	1.1	2.7
Mouth/teeth dental problems: Dentures	0.8	1.3	4.3	0.6	2.1	-0.5	0.6
Asthma	0.7	1.3	3.1	1.0	-0.4	1.8	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.4	0.3	-1.2	-0.4	0.8
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	0.3	0.3	0.4
Depression (self-reported)	0.5	0.6	1.3	-0.3	-0.7	1.1	0.6
Medication: Lansoprazole	2.3	2.6	6.8	1.1	-1.1	1.1	2.6
Prospective memory result	0.4	0.5	1.2	0.5	-0.3	0.5	-1.1
Lung cancer (father)	0.9	1.1	1.8	1.0	1.3	1.0	-0.5
Illnesses of mother	1.1	1.3	2.7	-0.1	1.0	-1.2	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.0	-1.7	-1.3	-1.2	-0.3
Pulse wave Arterial Stiffness index	1.1	1.3	2.6	1.6	-1.6	-0.3	-0.0
Impedance of arm (left)	0.4	2.0	6.1	0.3	1.4	-2.5	-0.2
Arm fat mass (right)	0.8	3.2	7.1	1.5	-0.9	1.6	2.7
Trunk predicted mass	0.4	2.2	5.4	0.4	-1.7	0.6	2.3
Standing height	0.3	3.2	9.8	0.8	-0.2	-1.6	3.1
Length of working week for main job	1.2	1.3	2.7	-0.3	-1.6	-0.3	-1.6
Exposure to tobacco smoke at home	0.5	0.6	1.8	-0.5	0.2	0.6	-1.3
Breastfed as a baby	0.9	1.1	2.2	-1.5	0.5	0.9	-1.0
Tense / ‘highly strung’	0.7	1.1	4.2	2.1	0.3	0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.5	1.4	-0.6	-0.2	2.1
Hair/balding pattern: Pattern 4	0.6	1.4	3.7	-1.2	0.5	-0.6	-1.9
Birth weight of first child	0.6	1.1	1.2	1.0	-1.1	1.0	1.1
Peak expiratory flow (PEF)	0.3	0.8	1.6	-1.3	-0.7	-0.6	-0.8
Pulse wave reflection index	0.1	0.1	0.2	0.3	-0.4	-0.5	-0.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	-0.4	-0.2	-0.4	-1.3
Loud music exposure frequency	0.1	0.2	0.4	0.6	0.4	-0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	12.4	1.0	0.2	-0.3	3.5
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.7	-1.3	-0.0	-1.8	-1.9
Blood clot in the leg (DVT)	1.9	2.5	5.8	2.4	-1.5	-0.2	1.4
Medication: Paracetamol	0.7	1.1	2.4	-1.4	1.6	-0.0	0.1
Headache pain in last month	0.8	1.4	3.3	1.8	1.0	-1.0	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	0.4	-0.8	-0.3	-0.6
Glaucoma (self-reported)	0.5	0.6	2.2	0.1	1.5	-0.5	-0.3
Gout (self-reported)	0.8	1.1	1.8	1.1	-0.6	1.0	1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	3.1	-1.3	-0.8	-0.7	1.8
Medication: Amlodipine	0.5	0.6	2.1	-0.5	0.5	1.4	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.5	-0.3	0.1	-0.1
Birth weight	0.1	0.2	0.5	-0.7	0.2	-0.1	-0.6
Chronic bronchitis/emphysema (mother)	2.5	2.9	6.9	-1.0	1.8	-2.6	-0.4
High blood pressure (siblings)	1.3	1.9	3.3	-0.8	1.5	1.8	1.2
Forced vital capacity (FVC), Best measure	0.2	0.9	2.6	-0.7	-1.6	-0.6	0.2
Body fat percentage	0.6	2.2	6.0	1.5	-0.2	0.9	2.5
Leg fat percentage (right)	0.3	1.1	2.5	0.9	-0.0	1.0	1.6
Arm fat-free mass (right)	0.6	3.0	6.7	1.1	-1.7	1.2	2.6
Exposure to tobacco smoke outside home	1.2	1.6	5.5	-0.9	0.2	-0.2	-2.4
Comparative body size at age 10	1.7	4.7	7.5	1.6	-1.8	2.7	2.4
Number of full brothers	1.1	1.4	4.6	-0.1	-0.9	2.2	-0.4
Worry too long after embarrassment	0.7	1.3	3.2	1.8	-0.7	-0.9	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	1.3	-0.5	0.7	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.4	-0.2	0.2	-0.6
Number of children fathered	1.3	1.4	3.1	1.0	-1.8	0.1	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.5	-1.2	-0.1	-0.3	-0.5
Age at first live birth	0.8	1.5	4.8	-0.4	0.4	-0.8	2.2
Pulse wave peak to peak time	1.0	1.1	2.5	-1.4	1.6	0.0	0.4
Health satisfaction	2.9	3.8	11.9	-1.6	-0.8	-0.0	-3.5
Shortness of breath walking on level ground	0.6	0.8	1.7	0.6	-1.3	-0.2	-1.0
Qualifications: College or University degree	0.5	1.6	3.9	1.2	-2.0	0.8	-0.5
Eye problems/disorders: None of the above	1.5	1.8	4.7	0.4	-1.4	-2.2	0.4
Mouth/teeth dental problems: Loose teeth	1.5	1.7	5.0	-0.2	0.6	-1.2	-2.2
Emphysema/chronic bronchitis	0.7	0.8	2.2	-0.2	1.5	-1.0	0.4
Medication for pain relief, constipation, heartburn	0.3	0.4	1.1	0.5	-1.1	0.2	-0.6
Neck or shoulder pain in last month	0.6	0.8	1.8	-1.4	0.8	-0.7	-0.4
Medication: Blood pressure	0.8	1.4	4.5	-0.1	0.6	0.9	2.1
Angina (self-reported)	0.6	0.8	2.0	1.1	-0.0	0.1	1.4
Migraine (self-reported)	3.3	4.1	7.1	2.7	1.5	0.6	2.6
Medication: Ibuprofen	0.4	0.5	1.2	0.7	-0.2	-0.5	1.1
Medication: Allopurinol	0.4	0.5	1.1	1.0	-0.0	0.5	0.7
Medication: Omeprazole	0.9	1.1	3.5	0.0	0.5	-0.8	1.9
Medication: Seretide 50 evohaler	1.6	1.9	5.3	-0.6	2.3	-0.5	-1.2
Mean time to correctly identify matches	1.2	2.2	7.1	1.1	0.4	0.5	2.7
Heart disease (mother)	1.3	1.6	3.1	1.2	-1.8	1.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.2	-0.6	-0.2	1.5	-0.6
Whole body fat mass	0.7	3.1	8.5	1.5	-0.5	1.2	2.9
Leg fat mass (right)	0.7	2.9	7.2	1.4	-0.4	1.4	2.7
Arm predicted mass (right)	0.5	2.7	5.6	0.9	-1.7	1.2	2.4
Pulse rate, automated reading	0.5	1.7	3.9	-0.6	0.3	1.5	-2.0
Alcohol intake frequency.	0.8	1.9	5.7	-0.7	1.1	0.3	-2.4
Comparative height size at age 10	0.3	1.6	5.1	0.4	-0.9	0.6	2.3
Number of full sisters	1.7	2.1	3.5	-1.4	1.9	1.6	-0.6
Suffer from ‘nerves’	0.7	1.1	2.1	0.5	0.8	-1.5	1.1
Overall health rating	0.3	0.6	1.0	0.2	1.0	0.7	-0.9
Chest pain or discomfort	0.9	1.3	2.3	1.3	-0.9	1.5	-0.4
Had major operations	3.9	4.6	13.0	2.0	-1.1	0.4	3.6
Age at last live birth	0.8	1.2	2.6	-1.6	1.0	-0.5	0.9
Family relationship satisfaction	5.2	6.4	17.3	-2.8	-0.6	0.1	-4.2
Leg pain on walking	0.1	0.2	0.2	-0.3	-0.2	-0.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	3.7	4.5	7.6	-2.8	0.9	-1.7	-2.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.8	-0.5	1.3	-0.2	0.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	4.3	-0.9	0.5	-0.9	-2.1
Medication: Aspirin	0.0	0.1	0.1	0.3	-0.2	0.0	0.2
Supplements: Vitamin C	0.2	0.2	0.7	0.3	0.9	-0.2	-0.4
Knee pain experienced in last month	0.2	0.3	0.5	-0.7	-0.3	0.5	-0.5
Hypertension (Self-reported)	0.8	2.3	7.0	-0.2	1.2	1.0	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	5.3	2.3	0.9	-0.4	0.8
Illnesses of father: Heart disease	0.3	0.4	1.1	0.3	0.1	0.4	1.1
Illnesses of siblings: Diabetes	0.2	0.3	0.9	-0.1	0.5	-0.2	-1.0
Smoking status: Previous	0.6	0.9	2.9	-0.6	-0.4	1.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.3	-1.4	-0.1	-1.5	-0.5
Whole body fat-free mass	0.5	3.1	6.8	0.9	-2.0	0.8	2.6
Leg fat-free mass (right)	0.5	2.7	5.9	1.0	-1.8	0.9	2.4
Arm fat percentage (left)	0.5	2.1	3.8	1.2	-0.8	1.5	1.9
Average weekly red wine intake	1.0	1.4	3.3	-1.8	1.4	-0.3	-0.5
Handedness (chirality/laterality): Left-handed	4.5	5.4	8.3	-2.1	2.0	-2.9	-2.2
Mood swings	0.6	1.0	4.1	2.0	-0.0	-0.1	-0.2
Loneliness, isolation	1.0	1.3	2.0	0.6	-1.4	1.4	-1.0
Long-standing illness, disability or infirmity	0.1	0.2	0.7	-0.1	0.8	-0.3	-0.1
Ever had bowel cancer screening	2.3	2.7	5.8	1.4	-0.9	1.4	2.4
Diabetes diagnosed by doctor	1.9	3.1	7.1	1.0	0.6	2.7	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.9	-1.4	0.7	-1.0	-0.7
Friendships satisfaction	2.0	2.5	4.8	-1.3	-1.8	-0.2	-2.2
Qualifications: nursing, teaching	3.1	4.8	6.4	2.5	-2.0	2.5	1.6
Commuting to job workplace: Walk	1.1	1.1	3.2	0.3	-1.8	-0.3	1.1
Eye problems/disorders: Cataract	0.8	0.9	2.2	-0.9	0.7	1.5	0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.8	1.7	-1.2	0.7	1.4
Medication for cholesterol	1.3	2.0	7.2	0.2	-0.8	0.2	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	6.7	-0.6	2.6	-1.8	0.6
Back pain experienced in last month	0.0	0.0	0.1	0.1	0.0	0.3	-0.1
Mineral and other dietary supplements	0.6	0.8	1.4	1.1	-1.2	0.2	0.7
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	-0.4	-0.5	-0.0
Asthma (self-reported)	0.6	1.3	2.7	1.2	-0.5	1.6	0.8
Osteoporosis (self-reported)	0.5	0.7	2.0	-0.2	-0.0	-0.7	1.4
Osteoarthritis (self-reported)	2.1	2.8	3.4	1.9	-1.9	1.9	0.9
Medication: Aspirin	0.3	0.4	0.6	0.6	-0.8	0.6	0.7
Medication: Gliclazide	0.9	1.1	2.4	0.4	0.6	1.5	1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	0.9	-0.7	-0.6	-1.6
Smoking status: Current	1.2	1.9	5.7	0.8	1.1	0.2	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.2	-0.2	-1.2	-1.8	0.2
Whole body water mass	0.5	2.8	6.9	0.9	-1.7	0.7	2.6
Leg predicted mass (right)	0.6	3.0	6.5	1.1	-1.8	0.9	2.6
Arm fat mass (left)	0.7	2.7	5.6	1.4	-0.8	1.6	2.4
Number of self-reported non-cancer illnesses	1.9	3.3	5.9	2.0	-1.2	1.3	2.4
Average weekly champagne plus white wine intake	2.4	3.3	11.2	1.1	-0.7	-0.6	3.3
Miserableness	1.2	2.1	5.9	2.4	-0.3	-0.4	1.4
Guilty feelings	0.3	0.4	1.0	1.0	0.6	0.3	0.2
Wears glasses or contact lenses	1.2	1.4	4.1	-0.7	2.0	0.2	0.9
Ever taken oral contraceptive pill	1.4	1.5	2.4	1.5	-1.4	-1.0	-0.9
Hearing aid user	0.4	0.4	1.1	0.7	1.0	0.2	-0.1
Mother’s age at death	11.2	14.0	22.5	4.7	-4.1	2.0	3.6
Financial situation satisfaction	1.8	2.2	7.1	-1.3	-0.4	-0.1	-2.7
Tinnitus: Yes, now most or all of the time	2.0	2.3	6.8	-1.2	-0.2	1.0	-2.6
Commuting to job workplace: Public transport	1.2	1.4	3.5	1.0	-1.9	0.8	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.8	1.0	0.5	0.3
Medication: Blood pressure	2.7	5.1	18.3	1.2	0.9	0.3	4.3
Pain type(s) experienced in last month: Hip pain	0.4	0.6	0.8	-0.8	0.1	-0.9	-0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.2	-1.5	1.2	-0.8	-1.5
High cholesterol (Self-reported)	0.7	1.2	3.0	-0.6	0.7	1.7	0.9
Medication: Bendroflumethiazide	2.4	3.6	6.1	2.1	-1.0	1.7	2.5
Medication: Paracetamol	0.6	0.9	2.5	-0.9	1.6	0.1	0.4
Medication: Lisinopril	0.3	0.4	0.9	0.2	-0.0	0.9	0.9
Medication: Atorvastatin	0.2	0.2	0.5	0.2	-0.6	0.7	-0.1
Illnesses of father: High blood pressure	1.1	1.3	3.5	-1.9	1.1	-0.7	-0.0
Alcohol drinker status: Never	1.4	1.7	3.6	1.9	-1.1	1.1	0.9
Ever smoked	1.1	2.0	5.6	1.0	-0.6	2.4	1.0
Basal metabolic rate	0.5	2.6	6.6	0.8	-1.6	0.9	2.6
Leg fat percentage (left)	0.3	0.9	2.1	0.7	-0.0	1.0	1.5
Arm fat-free mass (left)	0.4	2.3	6.5	0.8	-1.2	0.8	2.5
Number of operations (self-reported)	3.9	5.8	13.8	2.9	0.0	-1.0	3.7
Average weekly beer plus cider intake	0.5	0.7	1.1	-1.0	1.0	-0.9	0.2
Irritability	0.9	1.5	4.1	0.1	-0.6	-1.2	-2.0
Risk taking	4.0	5.8	20.4	-1.1	-1.1	0.6	-4.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.9	0.9	-1.4	-0.3	-0.2
Fractured/broken bones in last 5 years	1.6	2.1	3.9	1.7	-1.3	-0.3	2.0
Age started oral contraceptive pill	2.9	3.7	9.9	0.3	0.6	2.1	3.1
Diastolic blood pressure, automated reading	0.6	1.9	4.3	-1.4	-0.0	-1.2	-2.1
Ever depressed for a whole week	0.4	0.5	0.8	-0.7	-0.7	0.9	-0.5
Unable to work because of sickness or disability	0.8	1.1	2.2	-1.5	1.0	-0.1	-1.1
Commuting to job workplace: Cycle	1.4	1.7	4.4	-2.1	1.1	-0.8	-0.6
Myopia	0.4	0.6	1.1	0.3	-0.9	-0.5	-1.0
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.2	0.3	-1.1	0.1	-2.3
Cholesterol lowering medication	0.7	1.0	2.4	-0.0	0.7	1.0	1.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	7.2	0.2	0.5	-0.2	2.7
Pain experienced in last month	0.1	0.1	0.2	-0.4	-0.4	0.0	0.4
Supplements: Calcium	2.0	2.2	3.3	1.8	-1.6	-0.9	1.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-0.2	0.1	0.9	1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.0	0.0	1.0	-0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	5.2	2.3	-1.7	-0.2	1.3
Heart disease (siblings)	0.4	0.5	0.9	-1.0	0.6	-0.4	-0.7
Alcohol drinker status: Previous	1.4	1.6	3.0	-1.4	0.2	1.7	-1.2
Pack years of smoking	0.6	0.8	2.0	1.4	0.7	0.5	-0.8
Impedance of whole body	0.6	3.2	8.0	-0.1	2.0	-2.8	-0.8
Leg fat mass (left)	0.7	2.7	7.2	1.4	-0.4	1.3	2.7
Arm predicted mass (left)	0.5	2.8	7.2	1.0	-1.3	1.1	2.7