TWAS hub - TBCB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1519	0.0608	0.00710	-0.001	NA	0.049	NA	0.000	4.9e-01	NA	1.3e-05	NA	3.2e-01
2	GTEx	Nerve Tibial	0.1362	0.0472	0.00024	0.000	NA	0.051	NA	0.011	3.0e-01	NA	1.6e-04	NA	5.4e-02
3	YFS	Blood	0.0603	0.0252	0.01700	0.040	0	0.037	0.039	0.040	3.8e-13	0.49	4.4e-12	7.7e-13	5.2e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate	4.6	7.7	11.4	-3.4	-3.1	-1.5
Pulse rate, automated reading	4.3	13.8	35.6	-6.0	-2.4	-0.4
Number of live births	2.9	4.1	7.1	-1.4	2.7	1.9
Eye problems/disorders: Cataract	2.9	3.4	5.4	2.0	2.3	0.8
Wears glasses or contact lenses	2.9	3.3	4.7	1.0	2.2	2.1
Shortness of breath walking on level ground	2.7	3.2	7.2	1.5	2.7	-0.3
Medication for hormone replacement therapy	2.6	2.9	7.1	0.9	0.9	2.7
Alzheimer’s Disease (including proxy)	2.5	3.6	6.2	2.5	2.2	-0.2
Worrier / anxious feelings	2.5	4.7	11.2	3.3	-0.2	-1.7
Length of working week for main job	2.4	2.7	4.1	-2.0	1.8	0.9
Medication: Atorvastatin	2.3	2.8	4.9	-1.4	-1.3	-2.2
Age when periods started (menarche)	2.1	5.0	9.6	2.3	3.1	-0.0
Birth weight of first child	2.1	3.9	5.9	2.4	1.9	-1.5
Angina (self-reported)	2.1	2.7	5.7	-2.4	-0.9	1.3
Medication: Gliclazide	2.1	2.3	6.0	-1.0	2.4	-0.2
Alzheimer’s Disease (in mother)	1.9	2.2	4.1	1.5	2.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.4	1.2	0.8	-2.1
Eye problems/disorders: None of the above	1.9	2.2	3.8	-1.6	-1.9	0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.1	-1.2	2.0	1.0
Neuroticism (Nagel 2018)	1.8	4.3	6.5	2.5	1.0	-2.4
Worry (Nagel 2018)	1.8	3.8	7.0	2.0	0.7	-2.6
Mean Putamen Volume	1.8	2.0	5.6	-2.4	0.4	0.5
Primary Biliary Cirrhosis	1.8	2.6	4.0	0.6	-1.9	2.0
Had other major operations	1.8	2.2	3.6	-0.2	1.7	1.9
Heart disease (mother)	1.8	2.2	6.5	-0.2	-0.2	2.5
Angina	1.7	2.3	4.9	-2.2	-0.7	1.2
Chronic bronchitis/emphysema (father)	1.7	2.0	2.6	-1.6	-0.9	1.6
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.5	0.7	-2.1	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.6	0.3	1.9	1.5
Commuting to job workplace: Walk	1.7	1.8	2.2	-1.4	-1.5	1.0
Ever used hormone-replacement therapy (HRT)	1.6	2.0	5.1	0.1	0.9	2.3
Noisy workplace	1.6	2.0	3.2	1.5	-0.8	-1.8
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.5	-0.8	1.9	-1.1
Health satisfaction	1.6	2.1	3.7	1.9	1.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	7.5	1.4	-2.7	-0.9
Fractured/broken bones in last 5 years	1.6	2.0	4.2	-2.1	0.8	1.1
Prostate Cancer	1.5	2.1	4.9	-1.0	-2.2	-0.8
Chronotype (morning person)	1.5	3.5	4.7	-1.1	-2.2	-2.1
Vitamin and mineral supplements	1.5	2.1	5.9	-0.5	0.4	2.4
Townsend deprivation index at recruitment	1.5	2.1	4.6	-1.2	-0.5	2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.9	-1.3	-1.7	0.8
Mineral and other dietary supplements	1.5	2.0	3.5	1.9	0.8	1.3
Ever had hysterectomy (womb removed)	1.4	1.5	3.9	0.8	2.0	-0.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	3.0	1.3	1.7	-0.3
Supplements: Glucosamine	1.4	1.8	3.2	-0.9	-1.2	-1.8
Financial difficulties in last 2 years	1.4	1.8	3.7	-0.4	1.9	-1.3
Cholesterol lowering medication	1.4	2.0	3.7	-1.5	-0.4	-1.9
Qualifications: CSEs or equivalent	1.3	1.7	3.1	1.8	1.4	0.1
Nervous feelings	1.3	2.4	7.3	0.1	0.1	-2.7
Commuting to job workplace: Car/motor vehicle	1.3	1.4	3.6	0.9	1.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	7.9	2.8	-0.5	0.0
Illnesses of father: None of the above (group 1)	1.3	1.6	3.9	2.0	0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.8	-2.0	0.5	-0.7
Depressed Affect (Nagel 2018)	1.2	2.4	4.2	2.0	1.5	-0.9
Fasting Glucose	1.2	1.4	3.6	0.2	1.9	-0.7
Rheumatoid Arthritis	1.2	1.6	4.7	-0.1	2.2	-0.2
Illnesses of siblings	1.2	1.6	2.5	1.6	1.3	-0.8
Time employed in main current job	1.2	1.4	3.3	0.9	-1.8	-0.2
Mouth/teeth dental problems: Dentures	1.2	2.0	3.9	0.3	1.4	-2.0
Smoking status: Previous	1.2	1.7	4.2	0.4	-0.9	-2.0
Average weekly red wine intake	1.2	1.8	3.6	-1.3	-0.2	-1.9
Hearing aid user	1.2	1.4	3.3	-0.9	-1.8	-0.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.1	1.5	-0.5	-1.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.4	-1.2	0.8	-1.5
Supplements: Calcium	1.2	1.3	3.0	-1.7	0.0	-1.0
Major Depression (MDD)	1.1	1.3	2.0	-1.0	1.0	1.4
Lung FEV1/FVC ratio	1.1	5.4	14.4	1.4	3.8	-0.0
Lung FVC	1.1	5.8	15.9	0.3	-4.0	-1.2
Sensitivity / hurt feelings	1.1	1.9	4.1	1.2	0.5	-2.0
Past tobacco smoking	1.1	2.1	5.3	-0.5	0.8	2.3
Pain all over the body in last month	1.1	1.2	2.8	0.1	-1.7	0.8
Medication: Amlodipine	1.1	1.5	3.7	0.9	1.9	-0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.3	1.0	1.5	0.9
Migraine (self-reported)	1.1	1.4	3.8	-0.4	-0.2	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	2.7	0.4	1.6	0.9
Number of operations (self-reported)	1.1	1.7	3.8	0.1	1.9	1.2
Ever depressed for a whole week	1.1	1.3	1.9	0.9	1.1	1.4
Myopia	1.1	1.6	3.8	-0.9	0.6	1.9
Pack years of smoking	1.1	1.6	2.9	-0.9	1.0	-1.7
Schizophrenia vs Biploar Disorder	1.0	1.3	2.7	-1.0	-1.6	-0.3
Body Mass Index (BMI) (2010)	1.0	1.4	2.2	-1.1	1.5	0.8
Medication: Metformin	1.0	1.5	2.6	0.2	1.6	-1.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.6	-0.3	1.2	1.2
Trunk fat-free mass	1.0	5.5	11.6	3.4	2.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	8.0	2.8	-0.4	-1.3
Trunk predicted mass	1.0	5.6	11.6	3.4	2.2	0.8
Forced vital capacity (FVC), Best measure	1.0	3.7	7.3	2.7	-1.5	-1.2
Mean time to correctly identify matches	1.0	2.0	2.2	-1.4	1.5	1.3
Knee pain experienced in last month	1.0	1.6	3.8	-1.9	0.9	-0.3
Illnesses of father: Heart disease	1.0	1.4	3.9	-2.0	-0.4	-0.4
Basal metabolic rate	1.0	5.3	9.9	3.1	2.4	0.7
Average weekly beer plus cider intake	1.0	1.4	3.0	1.7	-0.8	-0.8
Bipolar Disorder (2018)	0.9	1.5	3.2	0.5	1.8	-1.0
Multivitamins +/- minerals	0.9	1.1	3.3	0.1	0.3	-1.8
Medication: Atenolol	0.9	1.2	1.7	-1.3	-0.5	1.2
Number of incorrect matches in round	0.9	1.5	3.7	0.1	-1.9	-0.9
Forced vital capacity (FVC)	0.9	3.6	4.5	2.1	-2.1	-1.4
Weight	0.9	4.3	7.7	2.3	2.8	0.1
Arm fat mass (right)	0.9	3.5	9.0	1.2	3.0	-0.1
Leg fat percentage (right)	0.9	3.3	8.8	-0.7	3.0	-0.9
Exposure to tobacco smoke outside home	0.9	1.2	2.0	1.4	0.4	1.2
Medication: Omeprazole	0.9	1.1	1.8	-1.2	0.1	-1.4
Whole body fat-free mass	0.9	4.9	10.0	3.2	2.0	0.9
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.3	0.9	1.5	0.4
Miserableness	0.9	1.5	1.7	1.3	1.3	-1.0
Ever smoked	0.9	1.6	4.6	0.2	-0.2	-2.1
Arm fat-free mass (left)	0.9	4.6	7.2	2.7	2.5	0.8
Irritability	0.9	1.6	2.4	1.3	-0.9	-1.5
Arm predicted mass (left)	0.9	4.5	7.3	2.7	2.4	0.8
Height	0.8	15.7	41.1	6.4	1.6	-1.9
Hand grip strength (left)	0.8	2.0	3.9	2.0	-1.4	0.0
Medication: Co-codamol	0.8	0.9	1.7	-1.0	0.2	1.3
Diabetes (mother)	0.8	1.1	3.0	0.3	-0.4	1.7
Arm fat percentage (right)	0.8	3.3	9.8	0.2	3.1	-0.2
Prospective memory result	0.8	1.0	2.0	1.4	0.9	0.2
Lung cancer (father)	0.8	1.0	1.5	0.7	1.2	1.0
Neck or shoulder pain in last month	0.8	1.2	2.4	-0.5	-1.0	-1.6
Medication: Seretide 50 evohaler	0.8	0.9	2.6	1.6	0.2	-0.2
Leg fat mass (right)	0.8	3.1	9.1	0.2	3.0	-0.4
Supplements: Vitamin C	0.8	1.0	2.4	0.5	0.4	-1.6
Mood swings	0.8	1.5	2.4	1.6	1.3	0.5
Whole body water mass	0.8	4.8	9.7	3.1	2.0	1.0
Average weekly champagne plus white wine intake	0.8	1.1	2.0	1.1	-1.4	0.3
Leg fat percentage (left)	0.8	2.9	7.8	-0.2	2.8	-0.9
Diastolic blood pressure, automated reading	0.8	2.5	6.8	-2.6	0.7	0.2
Lupus	0.7	1.0	1.2	1.0	0.9	-1.1
Ulcerative Colitis	0.7	1.0	1.5	1.2	-1.1	-0.5
Allergy or Eczema	0.7	1.9	2.9	1.7	0.7	-1.5
Pack years adult smoking proportion	0.7	1.1	2.0	-0.5	1.0	-1.4
Leg fat-free mass (left)	0.7	3.6	7.0	2.7	1.8	0.8
Body mass index (BMI)	0.7	2.9	8.4	0.5	2.9	0.3
Leg predicted mass (left)	0.7	3.6	6.6	2.6	1.9	0.8
Waist circumference	0.7	2.5	6.8	0.9	2.6	-0.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.4	0.6	1.0	1.2
Hip circumference	0.7	3.2	5.6	1.9	2.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.4	2.3	-0.6	-1.3
Exposure to tobacco smoke at home	0.7	0.8	1.3	-1.2	-0.8	0.7
Number of children fathered	0.7	0.8	1.9	-1.4	0.6	0.3
Medication: Allopurinol	0.7	0.9	2.4	0.3	0.4	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.4	0.1	-1.2	1.1
Chest pain or discomfort	0.7	1.0	3.0	0.2	1.7	0.3
Leg fat-free mass (right)	0.7	4.0	9.3	3.0	1.5	0.7
Arm fat percentage (left)	0.7	2.6	7.8	0.1	2.8	-0.2
Friendships satisfaction	0.7	0.9	2.2	-0.7	0.1	1.5
Qualifications: nursing, teaching	0.7	1.1	3.0	0.2	1.7	0.6
Leg predicted mass (right)	0.7	3.7	8.7	2.9	1.4	0.7
Arm fat mass (left)	0.7	2.8	7.3	1.0	2.7	-0.0
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.9	-1.4	-0.8	-0.6
Medication: Bendroflumethiazide	0.7	1.0	1.8	0.1	-1.1	-1.3
Medication: Paracetamol	0.7	1.0	3.0	1.7	0.3	-0.3
Leg fat mass (left)	0.7	2.8	8.0	0.5	2.8	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.5	3.0	0.8	1.7	-0.9
Depression (Nagel 2018)	0.6	0.9	1.4	1.0	1.2	-0.4
Neuroticism (2016)	0.6	0.9	1.6	-1.3	0.4	-1.0
Blood Red Count	0.6	5.4	9.5	-1.7	-1.9	-3.1
Hand grip strength (right)	0.6	1.6	4.6	2.1	-0.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.7	0.9	0.4	-1.3
Pulse wave reflection index	0.6	0.8	2.0	0.6	0.2	1.4
Medication: Paracetamol	0.6	1.0	2.5	1.6	0.1	-0.8
Arm fat-free mass (right)	0.6	3.3	5.8	2.4	1.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.5	0.1	-0.1	1.6
Wheeze or whistling in the chest in last year	0.6	1.1	2.4	0.2	1.5	0.9
Arm predicted mass (right)	0.6	2.9	5.3	2.3	1.7	0.7
Leg pain on walking	0.6	0.8	1.2	1.1	1.1	0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.7	0.2	-1.3	0.7
Medication for cholesterol	0.6	1.0	1.7	1.1	0.1	-1.3
Alcohol drinker status: Never	0.6	0.7	1.2	1.1	1.0	0.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	-0.3	1.2	-0.9
Irritable Bowel Disease (IBD)	0.5	1.3	3.7	1.9	-0.1	0.4
Reaction Time	0.5	0.9	2.0	-0.6	1.4	0.5
Ovarian Cancer	0.5	0.6	1.4	-0.6	0.3	-1.2
Crohns Disease (2012)	0.5	0.9	1.9	0.8	1.4	0.0
LDL Cholesterol	0.5	0.7	1.3	1.1	0.5	-0.8
Blood White Count	0.5	3.4	4.2	2.0	1.5	1.9
Neuroticism	0.5	1.2	1.6	1.1	0.9	-1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.9	0.1	1.4	0.2
Current tobacco smoking	0.5	0.8	1.4	-1.2	-0.2	0.9
Taking other prescription medications	0.5	0.7	2.0	-0.3	1.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-0.4	1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.9	0.2	-1.7	-0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.2	1.1	0.8	0.1
Medication: Levothyroxine sodium	0.5	0.9	1.1	-1.0	-0.7	-1.0
Sitting height	0.5	3.4	7.9	2.8	-1.3	0.8
Trunk fat mass	0.5	2.0	5.3	0.8	2.3	-0.5
Mouth/teeth dental problems	0.5	0.7	1.1	-1.1	0.7	0.7
Allergy	0.5	1.1	2.4	-1.6	-0.9	0.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	1.2	0.7	-0.3
Depression (self-reported)	0.5	0.5	1.3	-1.1	-0.2	0.6
Illnesses of mother	0.5	0.6	1.8	-1.3	0.2	-0.0
Standing height	0.5	5.0	14.9	3.9	-0.2	-0.3
Breastfed as a baby	0.5	0.6	1.4	1.2	0.5	0.3
Tense / ‘highly strung’	0.5	0.8	2.1	-0.4	-0.2	-1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	0.3	-0.5	1.4
Glaucoma (self-reported)	0.5	0.6	1.3	-0.2	1.1	-0.8
Body fat percentage	0.5	2.2	6.0	-0.3	2.4	-0.7
Number of full brothers	0.5	0.6	1.0	0.0	1.0	1.0
Age at first live birth	0.5	0.9	2.2	1.5	-0.2	0.6
Medication: Ibuprofen	0.5	0.6	0.7	0.8	0.7	-0.7
Whole body fat mass	0.5	2.2	5.8	0.8	2.4	-0.4
Age at last live birth	0.5	0.7	1.3	0.8	-0.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.6	-1.0	-0.2
High cholesterol (Self-reported)	0.5	0.9	1.8	-0.8	-1.3	-0.4
Risk taking	0.5	0.7	1.3	1.1	0.9	0.1
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.6	-0.3	-1.2
Crohns Disease (2017)	0.4	0.9	2.7	1.7	0.3	0.2
BMI	0.4	2.1	5.4	0.2	2.3	1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	0.5	1.1	0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	1.1	0.7	-0.1
Supplements: Zinc	0.4	0.5	1.3	0.2	0.1	-1.2
Trunk fat percentage	0.4	1.5	3.9	-0.2	2.0	-0.7
Maternal smoking around birth	0.4	0.6	1.0	-1.0	0.7	-0.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	0.9	0.4	-1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.2	1.2	0.3
Impedance of leg (left)	0.4	1.9	3.7	-0.9	-1.1	-1.9
Alcohol usually taken with meals	0.4	0.6	1.3	0.1	0.8	-1.1
Qualifications: None of the above	0.4	0.8	1.2	0.2	-1.0	-1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.5	1.2	0.1	-0.4
Neuroticism score	0.4	0.7	1.1	0.9	0.6	-1.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	-0.2	-1.1	0.1
Impedance of arm (left)	0.4	1.7	3.8	-0.5	-2.0	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.7	0.8	0.8	0.7
Loud music exposure frequency	0.4	0.4	1.1	1.1	-0.0	-0.4
Gout (self-reported)	0.4	0.6	1.6	-0.2	-0.4	-1.2
Birth weight	0.4	0.9	1.6	1.3	0.3	0.9
Worry too long after embarrassment	0.4	0.7	1.8	-0.3	0.3	-1.3
Pulse wave peak to peak time	0.4	0.5	1.3	0.5	1.2	-0.2
Emphysema/chronic bronchitis	0.4	0.4	0.7	0.5	0.9	0.5
Medication for pain relief, constipation, heartburn	0.4	0.7	1.0	-1.0	-1.0	0.1
Medication: Blood pressure	0.4	0.7	0.9	0.7	0.8	-0.9
Number of full sisters	0.4	0.5	1.2	-1.1	0.6	-0.0
Suffer from ‘nerves’	0.4	0.6	1.5	0.5	0.4	-1.2
Had major operations	0.4	0.4	0.9	0.5	0.9	0.3
Family relationship satisfaction	0.4	0.5	1.1	1.0	0.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-0.6	-0.1	-1.0
Illnesses of siblings: Diabetes	0.4	0.4	0.8	0.6	0.5	0.9
Breast cancer (self-reported)	0.4	0.5	1.2	1.1	0.5	-0.3
Smoking status: Current	0.4	0.6	1.6	-1.3	-0.4	0.4
Mother’s age at death	0.4	0.5	0.9	-0.4	-0.9	0.7
Alcohol drinker status: Previous	0.4	0.4	1.2	-0.1	1.1	-0.0
Impedance of whole body	0.4	1.9	2.4	-0.9	-1.6	-1.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.0	-0.2	0.2	-1.0
Hypothyroidism (self reported)	0.3	0.8	1.2	-1.1	-1.0	-0.4
Respiratory disease	0.3	0.7	1.3	1.1	1.0	0.1
Average weekly spirits intake	0.3	0.3	0.6	-0.8	-0.4	-0.5
Hearing difficulty/problems: Yes	0.3	0.5	1.0	-1.0	0.0	-0.7
Relative age of first facial hair	0.3	0.6	1.0	0.3	0.8	-1.0
Impedance of leg (right)	0.3	1.6	2.2	-1.5	-0.7	-1.4
Fed-up feelings	0.3	0.5	1.5	1.2	-0.2	0.0
Relative age voice broke	0.3	0.4	0.6	0.8	0.5	-0.6
High blood pressure (mother)	0.3	0.4	0.5	0.4	0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	-0.5	-1.1	-0.7
Diabetes (self-reported)	0.3	0.4	1.1	0.1	1.1	0.3
Father’s age at death	0.3	0.5	0.9	-0.2	0.6	1.0
Happiness	0.3	0.4	0.7	0.1	-0.9	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.8	0.0	-0.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.4	0.0	-0.3	1.5
Peak expiratory flow (PEF)	0.3	0.7	0.9	1.0	-0.9	-0.6
Alcohol intake frequency.	0.3	0.7	2.0	-1.4	-0.4	0.2
Comparative height size at age 10	0.3	1.5	2.7	1.3	-1.6	-0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.1	-0.5	1.0	-0.4
Diabetes diagnosed by doctor	0.3	0.5	1.4	0.3	1.2	0.4
Commuting to job workplace: Public transport	0.3	0.4	0.6	-0.2	-0.8	-0.6
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.8	0.6	-0.1
Medication: Lisinopril	0.3	0.4	1.1	-1.0	0.3	-0.1
Illnesses of father: High blood pressure	0.3	0.4	0.6	0.8	-0.5	-0.7
Schizophrenia (2018)	0.2	0.5	0.8	0.6	0.9	-0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.4	0.2	0.7
Ulcerative Colitis (UC)	0.2	0.4	1.2	1.1	0.0	-0.0
HbA1C	0.2	0.3	0.4	0.3	-0.7	0.5
HDL Cholesterol	0.2	0.3	0.7	-0.0	-0.3	-0.9
Triglycerides	0.2	0.4	0.9	-0.6	-0.1	0.9
Blood Platelet Count	0.2	1.9	4.8	-0.7	2.2	-0.6
Waist Hip Ratio (WHR)	0.2	0.9	2.1	0.4	1.4	-0.7
Number of treatments/medications taken	0.2	0.3	0.6	0.4	0.3	-0.8
Diabetes (father)	0.2	0.2	0.7	-0.8	0.0	0.3
Severe depression (siblings)	0.2	0.3	0.7	0.1	-0.8	-0.3
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.1	0.5	-0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.3	-0.6	-0.7
Medication: Ramipril	0.2	0.2	0.6	0.7	0.4	-0.1
Impedance of arm (right)	0.2	1.1	1.9	-0.4	-1.4	-1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	0.2	-0.1	1.2
Medication: Lansoprazole	0.2	0.2	0.5	-0.3	0.7	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.2	-0.0	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.4	-0.6	0.2
Headache pain in last month	0.2	0.4	0.8	0.9	0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.7	-0.8	-0.3	-0.8
High blood pressure (siblings)	0.2	0.3	0.6	-0.8	-0.3	0.5
Medication: Aspirin	0.2	0.3	0.6	-0.3	0.5	0.8
Loneliness, isolation	0.2	0.3	0.6	-0.5	0.4	0.8
Ever had bowel cancer screening	0.2	0.2	0.6	-0.4	0.8	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.8	-0.2	0.6
Medication: Aspirin	0.2	0.3	0.8	-0.2	0.9	0.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	0.5	0.9	0.3
Medication: Blood pressure	0.2	0.3	0.6	-0.5	-0.8	-0.0
Unable to work because of sickness or disability	0.2	0.2	0.4	0.5	-0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.4	-0.4	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	-0.8	0.7	0.0
Age at First Birth	0.1	0.2	0.3	-0.1	-0.4	0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.1	0.5	-0.3
Schizophrenia (2014)	0.1	0.1	0.2	0.1	0.5	0.4
Heel T-Score	0.1	0.7	1.5	0.7	-1.2	-0.2
Systolic Blood Pressure	0.1	0.3	0.5	-0.4	-0.6	-0.7
Smoking Status	0.1	0.2	0.4	0.1	-0.2	-0.6
Cardiovascular Disease	0.1	0.3	0.7	0.5	0.1	-0.8
Tanning	0.1	1.2	2.1	-1.5	-0.4	1.1
Systolic blood pressure, automated reading	0.1	0.2	0.5	-0.7	0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.4	-0.0	0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.5	-0.3	0.1
Had menopause	0.1	0.1	0.2	0.3	0.4	-0.0
Heart attack	0.1	0.2	0.4	-0.2	0.6	-0.3
Fluid intelligence score	0.1	0.3	0.5	-0.4	-0.3	-0.7
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.3	0.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.4	0.3	0.6
Falls in the last year	0.1	0.2	0.6	-0.8	-0.1	-0.1
Asthma	0.1	0.1	0.2	0.3	0.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.2	-0.1	0.7
Qualifications: College or University degree	0.1	0.4	0.8	0.9	0.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.1	0.6	0.3
Overall health rating	0.1	0.2	0.3	-0.6	-0.1	0.4
Back pain experienced in last month	0.1	0.2	0.5	-0.7	0.0	0.3
Osteoporosis (self-reported)	0.1	0.2	0.3	0.4	-0.1	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.1	-0.3	0.5
Guilty feelings	0.1	0.1	0.3	0.1	0.1	-0.5
Financial situation satisfaction	0.1	0.1	0.3	0.6	-0.0	0.3
Pain experienced in last month	0.1	0.2	0.2	0.5	-0.4	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.4	0.5	0.0
Heart disease (siblings)	0.1	0.2	0.5	-0.2	-0.2	0.7
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.4	-0.2	-0.2
Breast Cancer	0.0	0.1	0.2	-0.1	0.3	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.2	0.4	0.3	-0.2	-0.6
Hair Pigment	0.0	0.6	1.1	-0.2	-1.1	-0.9
Average weekly fortified wine intake	0.0	0.0	0.1	-0.3	-0.2	-0.1
High blood pressure	0.0	0.1	0.2	-0.1	-0.3	-0.4
Medication: Simvastatin	0.0	0.1	0.1	-0.4	0.1	-0.3
Medication: Cholesterol lowering	0.0	0.0	0.1	-0.1	-0.1	0.2
Comparative body size at age 10	0.0	0.1	0.1	0.2	0.0	0.3
Hypertension (Self-reported)	0.0	0.1	0.4	-0.1	-0.1	-0.6
Asthma (self-reported)	0.0	0.1	0.2	0.3	0.2	0.4
Ever taken oral contraceptive pill	0.0	0.1	0.1	0.1	-0.4	-0.1
Age started oral contraceptive pill	0.0	0.1	0.2	0.1	-0.1	0.4
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.1	0.4	0.2

Hub : Genes

TBCB

Models

Trait associations