Hub : Genes

TDRD7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0760 0.0360 0.00290 -0.003 NA -0.003 NA -0.002 9.7e-01 NA 8.7e-01 NA 6.0e-01
2 YFS Blood 0.0257 0.0094 0.00012 0.015 0.01 0.012 0.012 0.011 6.3e-06 0.0003 7.6e-05 6.4e-05 9.1e-05
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0340 0.0173 0.00075 0.032 0.02 0.017 NA 0.024 1.6e-04 0.0021 4.6e-03 NA 8.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 0.9 1.2 1.1 -1.0 -0.8
Bipolar Disorder or Schizophrenia 0.5 1.3 2.1 0.5 -1.4 -1.3
Depressed Affect (Nagel 2018) 0.3 0.7 1.4 -0.4 0.7 1.2
Depression (Nagel 2018) 0.1 0.2 0.6 0.2 -0.7 -0.3
Intelligence (Savage-Jansen 2018) 1.4 4.3 5.6 -1.7 2.1 2.4
Neuroticism (Nagel 2018) 0.1 0.3 0.7 0.4 -0.2 0.8
Schizophrenia (2018) 0.4 0.7 1.2 -0.3 -1.1 -1.0
Schizophrenia vs Biploar Disorder 0.0 0.0 0.1 -0.0 0.2 0.3
Worry (Nagel 2018) 0.6 1.3 2.5 1.6 0.1 1.1
Alzheimer’s Disease (in mother) 0.8 1.0 1.1 -1.0 1.1 0.9
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.6 0.4 0.2
Alzheimer’s Disease (including proxy) 1.2 1.7 2.1 -1.3 1.4 1.1
Crohns Disease (2017) 0.1 0.1 0.2 -0.3 -0.3 -0.5
Irritable Bowel Disease (IBD) 0.4 1.0 1.8 1.3 -0.7 -0.9
Ulcerative Colitis (UC) 1.5 2.8 6.9 2.6 -0.6 -1.0
Major Depression (MDD) 0.5 0.6 1.1 1.1 0.3 0.7
Reaction Time 0.3 0.5 1.0 -0.5 -1.0 0.5
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.0 -0.9 1.2 1.7
Breast Cancer 0.3 0.8 1.3 0.6 -1.1 -0.9
Ovarian Cancer 0.5 0.6 1.7 -1.3 0.2 -0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.6 2.3 3.4 1.8 -1.5 -1.1
Bipolar Disorder (2011) 1.7 1.6 2.8 0.5 -1.7 -1.4
Body Mass Index (BMI) (2010) 1.3 1.8 3.9 0.0 -1.2 -2.0
Coronary Artery Disease (CAD) 3.4 4.1 5.7 -1.4 2.2 2.4
Crohns Disease (2012) 0.1 0.2 0.3 -0.2 0.5 0.6
Mean Putamen Volume 0.1 0.1 0.1 -0.1 0.3 0.3
Fasting Glucose 2.0 2.3 6.3 -2.5 -0.2 0.8
HbA1C 5.6 6.2 13.6 3.7 -1.7 -1.5
HDL Cholesterol 0.1 0.1 0.2 -0.2 0.5 0.2
LDL Cholesterol 0.1 0.2 0.3 0.4 -0.3 -0.5
Lupus 0.2 0.2 0.3 0.6 0.1 -0.6
Neuroticism (2016) 0.1 0.1 0.2 0.2 -0.5 -0.3
Primary Biliary Cirrhosis 1.5 2.2 4.2 0.4 -1.5 -2.0
Rheumatoid Arthritis 0.4 0.6 0.6 -0.8 0.8 0.7
Schizophrenia (2014) 0.4 1.0 1.6 -0.2 -1.1 -1.2
Triglycerides 0.5 0.9 0.9 0.9 0.9 1.0
Type 2 Diabetes (T2D) (2012) 2.4 2.8 3.6 1.5 -1.6 -1.9
Ulcerative Colitis 0.5 0.7 1.7 1.3 -0.4 -0.5
Blood Eosinophil Count 0.0 0.3 0.5 0.5 -0.7 0.1
Blood Platelet Count 1.2 13.8 29.8 3.2 -1.1 -5.5
Blood Red Count 0.0 0.2 0.5 -0.1 -0.2 0.7
Blood White Count 0.4 2.7 6.8 -2.6 1.1 -0.1
Heel T-Score 0.1 0.9 1.1 1.0 -0.7 -1.1
BMI 0.3 1.9 4.1 -2.0 1.2 0.5
Height 0.2 3.1 9.0 0.6 -0.1 3.0
Waist Hip Ratio (WHR) 0.4 1.9 2.0 1.2 1.4 1.4
Systolic Blood Pressure 0.2 0.9 1.6 0.4 -1.3 -0.9
Smoking Status 0.1 0.2 0.4 -0.0 -0.4 -0.6
Allergy or Eczema 0.3 0.7 1.8 -1.3 0.1 0.5
Cardiovascular Disease 0.1 0.4 0.6 -0.6 -0.2 0.8
Hypothyroidism (self reported) 0.7 1.6 3.6 -0.7 1.9 -0.9
Respiratory disease 0.6 1.2 2.1 0.4 -1.2 -1.4
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.5 0.7 0.1 0.2
Lung FEV1/FVC ratio 0.4 1.9 2.0 -1.3 -1.4 1.4
Lung FVC 0.4 1.9 4.4 0.6 -0.9 -2.1
Neuroticism 0.5 1.3 2.9 -0.1 0.9 1.7
Chronotype (morning person) 5.5 12.8 19.3 2.3 -4.4 -3.7
Hair Pigment 0.0 0.5 1.2 1.1 0.0 -0.5
Tanning 0.0 0.2 0.3 0.2 0.4 0.6
Hand grip strength (left) 2.4 6.2 9.2 2.4 -2.0 -3.0
Number of treatments/medications taken 0.3 0.6 1.1 -0.5 0.6 1.1
Average weekly spirits intake 1.2 1.4 1.5 1.2 -1.2 -1.2
Sensitivity / hurt feelings 0.4 0.7 0.8 0.9 -0.7 -0.9
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.1 -0.5 -0.2
Hearing difficulty/problems: Yes 0.7 1.0 3.0 -1.7 -0.2 0.2
Relative age of first facial hair 0.4 0.8 2.1 1.4 -0.5 0.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.1 -0.3 0.5 1.5
Ever used hormone-replacement therapy (HRT) 1.3 1.6 2.5 -1.1 -1.0 -1.6
Ever had hysterectomy (womb removed) 0.2 0.3 0.8 0.9 -0.1 -0.1
Systolic blood pressure, automated reading 0.0 0.0 0.0 -0.2 -0.2 -0.2
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.1 -0.3 0.7 1.1
Angina 0.2 0.2 0.4 -0.5 0.2 0.6
Medication for hormone replacement therapy 0.3 0.3 0.7 -0.1 -0.8 -0.6
Vitamin and mineral supplements 1.2 1.6 3.1 -0.4 1.8 1.2
Supplements: Zinc 0.3 0.3 0.6 0.8 -0.4 -0.3
Medication: Co-codamol 0.2 0.3 0.3 -0.6 0.5 0.4
Medication: Metformin 0.2 0.2 0.5 -0.7 0.1 0.5
Diabetes (father) 0.2 0.3 0.5 -0.2 -0.6 -0.7
Diabetes (mother) 0.9 1.1 2.4 -0.6 0.7 1.6
Severe depression (siblings) 0.1 0.1 0.3 0.5 0.0 0.0
Pack years adult smoking proportion 0.7 1.0 1.7 -0.5 1.1 1.3
Impedance of leg (right) 0.3 1.7 4.0 0.6 -0.8 -2.0
Leg fat-free mass (left) 1.0 5.3 10.4 -1.5 1.8 3.2
Trunk fat percentage 2.0 8.1 8.9 -2.8 2.7 3.0
Hand grip strength (right) 1.5 4.0 5.8 1.4 -2.1 -2.4
Townsend deprivation index at recruitment 0.9 1.3 2.1 -0.2 1.5 1.3
Current tobacco smoking 1.1 1.8 2.3 -1.3 1.5 1.2
Average weekly fortified wine intake 0.7 0.8 1.5 0.7 -1.2 -0.7
Maternal smoking around birth 0.5 0.7 1.3 -0.1 0.8 1.1
Fed-up feelings 0.5 0.9 1.6 -0.8 1.3 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.1 -0.3 0.2 0.3
Relative age voice broke 1.6 2.4 4.3 2.1 -1.4 -1.1
Taking other prescription medications 0.6 1.0 1.9 -1.4 0.7 0.8
Age when periods started (menarche) 0.4 1.0 2.9 1.7 -0.3 0.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.9 -0.4 -0.6 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.2 0.9 -1.1 -0.3
Tinnitus: Yes, but not now, but have in the past 1.7 1.9 4.3 2.1 -0.6 -0.9
Qualifications: CSEs or equivalent 0.8 1.1 1.8 -0.2 1.2 1.3
Serious illness, injury or assault to yourself 0.2 0.3 0.4 0.5 -0.5 -0.6
High blood pressure 1.1 2.9 5.6 -2.4 0.2 1.8
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.5 -1.9 0.2 0.5
Multivitamins +/- minerals 0.8 1.0 1.8 0.3 -1.3 -1.1
Stomach or abdominal pain in last month 0.8 1.0 1.8 0.3 1.3 1.1
Supplements: Glucosamine 0.6 0.7 1.5 -1.2 -0.3 0.8
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.6 -1.3 0.9 0.1
Medication: Atenolol 0.4 0.5 1.0 0.2 0.6 1.0
Medication: Levothyroxine sodium 1.3 2.2 5.1 -1.1 2.2 -0.5
Sitting height 0.3 2.1 5.2 0.0 1.0 2.3
Chronic bronchitis/emphysema (father) 0.8 1.0 1.7 -1.1 1.3 0.2
High blood pressure (mother) 2.2 3.1 9.0 3.0 -0.5 -0.2
Body mass index (BMI) 1.8 7.6 8.6 -2.9 2.5 2.9
Impedance of leg (left) 0.5 2.4 4.4 1.4 -1.0 -2.1
Leg predicted mass (left) 1.0 5.2 10.2 -1.4 1.8 3.2
Trunk fat mass 2.4 10.3 12.5 -3.2 2.9 3.5
Waist circumference 1.9 7.1 11.2 -1.9 2.5 3.4
Number of incorrect matches in round 1.1 1.8 2.5 1.0 -1.6 -1.3
Past tobacco smoking 0.2 0.3 0.6 -0.7 0.3 0.6
Alcohol usually taken with meals 8.0 13.0 21.9 1.2 -3.9 -4.7
Nervous feelings 0.1 0.2 0.6 -0.1 0.4 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.8 0.4 -1.3 -0.8
Hearing difficulty/problems with background noise 1.0 1.5 2.0 -1.2 -1.4 -1.0
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.4 0.4 0.1
Had menopause 0.9 1.1 2.1 -1.4 -1.1 -0.1
Had other major operations 2.0 2.4 5.0 -2.2 0.7 1.3
Forced vital capacity (FVC) 0.2 0.9 1.6 1.2 -0.9 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 0.2 -1.3 -0.5
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.1 0.8 -1.1 -0.8
Qualifications: None of the above 0.1 0.1 0.2 0.3 0.3 -0.5
Financial difficulties in last 2 years 0.2 0.3 0.8 0.5 0.9 -0.0
Mouth/teeth dental problems 2.6 4.0 8.2 0.4 -1.9 -2.9
Heart attack 0.4 0.5 1.3 -0.1 0.5 1.2
Allergy 0.2 0.5 1.2 1.1 0.4 0.4
Pain all over the body in last month 1.0 1.0 2.0 -0.2 -1.0 -1.4
Diabetes (self-reported) 0.1 0.2 0.4 0.2 0.2 0.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.3 -0.4 -0.6 -0.2
Medication: Ramipril 1.4 1.8 3.9 -0.7 0.9 2.0
Medication: Simvastatin 0.2 0.3 0.7 0.2 -0.8 -0.3
Fluid intelligence score 1.7 3.6 6.0 -1.2 1.8 2.4
Illnesses of siblings 0.0 0.0 0.1 -0.2 0.2 -0.1
Neuroticism score 0.6 1.3 2.7 -0.0 1.1 1.6
Weight 1.8 8.7 12.6 -2.8 2.4 3.5
Impedance of arm (right) 0.5 2.3 4.0 2.0 -0.9 -1.5
Arm fat percentage (right) 1.8 7.0 7.6 -2.8 2.5 2.7
Trunk fat-free mass 0.6 3.5 6.4 -1.8 1.0 2.5
Hip circumference 1.5 6.4 10.1 -2.3 1.9 3.2
Time employed in main current job 0.8 1.0 1.9 -0.7 -1.4 -0.7
Alcohol intake versus 10 years previously 0.5 0.7 1.3 -0.5 0.8 1.1
Father’s age at death 0.0 0.1 0.2 -0.1 0.2 0.4
Worrier / anxious feelings 0.2 0.3 0.8 -0.4 0.2 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 0.2 0.8 -0.1
Falls in the last year 3.2 4.3 8.3 -0.2 -2.1 -2.9
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.0 -0.5 -0.8
Number of live births 0.3 0.5 0.7 -0.4 -0.8 -0.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 1.1 0.7 -1.0 -0.1
Pulse rate 1.4 2.4 3.7 -0.0 1.8 1.9
Happiness 0.3 0.4 0.9 -0.9 0.4 -0.3
Noisy workplace 0.9 1.2 1.8 -1.3 1.3 -0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 -0.8 -0.2 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 2.4 -0.3 -1.5 -0.8
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.2 0.5 0.4
Asthma 0.2 0.3 0.5 0.2 -0.6 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 0.3 0.7 0.4
Medication: Cholesterol lowering 0.1 0.1 0.2 0.4 -0.4 -0.1
Depression (self-reported) 1.4 1.6 2.7 -0.5 1.4 1.6
Medication: Lansoprazole 0.8 0.9 2.2 1.5 -0.7 0.2
Prospective memory result 0.4 0.4 0.8 0.1 -0.9 -0.7
Lung cancer (father) 0.6 0.7 1.2 -0.8 1.1 0.6
Illnesses of mother 0.9 1.1 2.9 -1.7 0.2 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.1 1.1 -0.9 -0.2
Pulse wave Arterial Stiffness index 0.2 0.3 0.4 0.6 -0.6 -0.3
Impedance of arm (left) 0.3 1.5 3.0 1.7 -0.7 -1.1
Arm fat mass (right) 2.1 8.7 11.1 -2.8 2.7 3.3
Trunk predicted mass 0.6 3.5 6.3 -1.8 1.0 2.5
Standing height 0.1 1.5 4.3 -0.2 0.3 2.1
Length of working week for main job 0.3 0.4 0.9 -1.0 0.3 0.3
Exposure to tobacco smoke at home 0.2 0.2 0.5 0.3 0.3 0.7
Breastfed as a baby 0.9 1.1 1.4 -1.0 -1.2 -0.9
Tense / ‘highly strung’ 0.8 1.3 2.3 -0.0 1.2 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.0 0.9 0.6 1.0
Hair/balding pattern: Pattern 4 0.3 0.6 1.3 1.1 -0.4 -0.7
Birth weight of first child 0.2 0.4 1.3 -0.1 1.1 0.1
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.1 -0.7 -0.5
Pulse wave reflection index 1.3 1.6 2.4 1.1 -1.5 -1.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 0.1 -0.6 0.5
Loud music exposure frequency 0.5 0.5 1.5 1.2 0.3 -0.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.4 -0.3 -1.2 -0.8
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 3.8 0.1 1.5 1.9
Blood clot in the leg (DVT) 0.9 1.1 2.1 0.3 -1.1 -1.4
Medication: Paracetamol 0.3 0.5 1.3 1.2 -0.4 -0.1
Headache pain in last month 0.7 1.2 1.8 -1.3 0.7 1.1
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.4 1.5 0.2 -1.2
Glaucoma (self-reported) 1.4 1.6 2.5 -0.6 1.4 1.6
Gout (self-reported) 0.7 1.0 2.5 0.4 -0.5 -1.6
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 5.8 -0.2 2.4 -0.5
Medication: Amlodipine 0.6 0.8 2.2 0.0 0.5 1.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.5 1.6 0.7 0.3
Birth weight 0.1 0.3 0.6 0.8 -0.2 -0.4
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.6 0.8 0.8 -0.2
High blood pressure (siblings) 0.4 0.6 1.0 0.7 0.6 1.0
Forced vital capacity (FVC), Best measure 0.4 1.6 3.4 1.8 -0.9 -0.7
Body fat percentage 2.2 8.6 8.9 -3.0 2.9 3.0
Leg fat percentage (right) 2.9 10.5 12.9 -3.6 3.1 3.0
Arm fat-free mass (right) 0.9 4.5 7.4 -2.1 1.3 2.7
Exposure to tobacco smoke outside home 3.0 4.0 7.7 -0.3 2.1 2.8
Comparative body size at age 10 0.6 1.7 3.0 -1.7 1.1 1.0
Number of full brothers 1.2 1.5 2.0 -0.9 1.4 1.3
Worry too long after embarrassment 0.1 0.1 0.2 0.0 -0.4 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.7 -0.2 0.8 0.8
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 0.8 -0.1 -0.5
Number of children fathered 0.9 1.0 1.8 0.7 -1.3 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.4 -0.3 -0.9 -1.2
Age at first live birth 3.1 5.4 7.5 2.7 -2.1 -2.1
Pulse wave peak to peak time 0.3 0.4 0.4 -0.6 0.6 0.6
Health satisfaction 0.5 0.7 1.1 -1.0 -0.1 -0.9
Shortness of breath walking on level ground 0.3 0.4 0.6 0.5 0.5 0.8
Qualifications: College or University degree 0.3 1.0 1.9 -0.2 -1.4 -1.0
Eye problems/disorders: None of the above 0.6 0.7 1.5 0.7 -0.3 -1.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.9 0.9 -0.1 -0.3
Emphysema/chronic bronchitis 0.1 0.1 0.3 -0.5 0.3 0.1
Medication for pain relief, constipation, heartburn 0.1 0.1 0.4 0.0 0.2 -0.6
Neck or shoulder pain in last month 2.7 3.8 6.3 -0.5 2.5 2.2
Medication: Blood pressure 1.3 2.2 5.5 -2.3 -0.5 1.0
Angina (self-reported) 0.3 0.4 0.8 -0.6 0.5 0.9
Migraine (self-reported) 0.1 0.1 0.2 -0.4 -0.4 -0.1
Medication: Ibuprofen 0.2 0.3 0.7 0.8 -0.1 -0.4
Medication: Allopurinol 0.2 0.3 0.6 -0.8 -0.3 -0.6
Medication: Omeprazole 0.5 0.6 1.3 -0.4 -1.1 -0.6
Medication: Seretide 50 evohaler 0.7 0.8 1.0 -0.7 1.0 1.0
Mean time to correctly identify matches 0.7 1.2 2.6 -1.6 -0.8 0.7
Heart disease (mother) 0.0 0.0 0.0 -0.0 0.1 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.6 -0.6 0.6 0.8
Whole body fat mass 2.2 9.3 10.8 -3.0 2.8 3.3
Leg fat mass (right) 2.6 9.9 10.8 -3.2 2.9 3.3
Arm predicted mass (right) 0.8 4.1 6.4 -2.1 1.2 2.5
Pulse rate, automated reading 0.7 2.4 4.0 -2.0 1.2 1.3
Alcohol intake frequency. 0.5 1.1 2.7 -1.6 -0.6 0.5
Comparative height size at age 10 0.1 0.6 1.3 -0.3 -0.5 1.1
Number of full sisters 0.3 0.3 0.7 0.2 0.5 0.8
Suffer from ‘nerves’ 0.2 0.2 0.7 0.2 0.1 0.8
Overall health rating 0.4 0.8 1.6 -1.3 0.7 0.5
Chest pain or discomfort 0.5 0.8 1.2 -1.0 0.3 1.1
Had major operations 0.7 0.8 2.4 0.1 1.5 0.2
Age at last live birth 4.1 6.0 7.6 2.8 -2.3 -2.3
Family relationship satisfaction 0.9 1.1 2.3 0.2 1.5 0.9
Leg pain on walking 0.8 1.0 1.5 -0.2 -1.1 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.2 -0.2 1.1 0.8
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.3 0.5 -0.3 -1.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.0 -1.0 1.0 0.6
Medication: Aspirin 1.1 1.5 3.6 0.2 0.9 1.9
Supplements: Vitamin C 0.2 0.3 0.5 0.3 -0.4 0.7
Knee pain experienced in last month 1.9 3.0 3.5 -1.7 1.5 1.9
Hypertension (Self-reported) 0.8 2.2 3.7 -1.9 0.4 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 0.8 0.5 -0.9 -0.8
Illnesses of father: Heart disease 0.2 0.3 0.8 -0.9 0.2 0.2
Illnesses of siblings: Diabetes 0.2 0.3 0.3 0.6 -0.5 -0.5
Smoking status: Previous 0.4 0.7 0.9 0.9 -0.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.6 -0.5 -1.0 -1.2
Whole body fat-free mass 0.8 4.4 8.3 -1.7 1.4 2.9
Leg fat-free mass (right) 0.8 4.2 9.3 -1.0 1.6 3.0
Arm fat percentage (left) 2.4 9.4 10.0 -3.1 2.9 3.2
Average weekly red wine intake 0.9 1.3 1.5 -1.2 -1.1 -1.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.7 1.3 -0.3 -0.2
Mood swings 0.1 0.2 0.3 -0.3 0.5 0.5
Loneliness, isolation 1.0 1.3 2.2 0.7 1.5 1.1
Long-standing illness, disability or infirmity 1.0 1.5 3.8 -1.9 0.5 0.8
Ever had bowel cancer screening 0.1 0.2 0.4 -0.7 0.2 0.1
Diabetes diagnosed by doctor 0.1 0.1 0.4 -0.0 0.3 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 -0.2 0.5 -0.7
Friendships satisfaction 0.1 0.1 0.3 -0.1 0.6 -0.1
Qualifications: nursing, teaching 0.2 0.2 0.5 -0.4 -0.7 -0.3
Commuting to job workplace: Walk 0.9 0.9 1.8 0.0 1.0 1.4
Eye problems/disorders: Cataract 0.2 0.2 0.5 -0.7 -0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 4.9 -0.5 1.8 2.2
Medication for cholesterol 1.1 1.6 3.8 0.5 -0.9 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.4 -0.4 0.0
Back pain experienced in last month 0.0 0.0 0.1 0.2 -0.2 -0.1
Mineral and other dietary supplements 0.7 0.9 2.4 0.3 1.5 0.4
Breast cancer (self-reported) 0.1 0.2 0.3 0.0 0.6 0.3
Asthma (self-reported) 0.1 0.2 0.4 0.4 -0.4 -0.6
Osteoporosis (self-reported) 1.1 1.3 2.9 0.2 -1.0 -1.7
Osteoarthritis (self-reported) 0.2 0.3 0.5 -0.7 -0.1 0.6
Medication: Aspirin 0.8 1.1 2.7 0.4 0.7 1.6
Medication: Gliclazide 0.2 0.2 0.4 -0.2 -0.5 -0.6
Illnesses of father: None of the above (group 1) 0.5 0.7 2.0 1.4 0.2 0.2
Smoking status: Current 1.0 1.7 2.2 -1.2 1.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.0 -1.0 0.0 0.6
Whole body water mass 0.7 4.2 8.1 -1.6 1.3 2.8
Leg predicted mass (right) 0.8 4.2 9.4 -0.9 1.6 3.1
Arm fat mass (left) 2.4 9.9 11.9 -3.1 2.9 3.5
Number of self-reported non-cancer illnesses 0.2 0.3 0.6 -0.8 -0.5 -0.2
Average weekly champagne plus white wine intake 1.4 1.9 3.0 0.7 -1.7 -1.4
Miserableness 1.1 1.9 3.5 -0.5 1.4 1.9
Guilty feelings 0.3 0.5 1.0 -1.0 -0.6 0.0
Wears glasses or contact lenses 0.2 0.3 0.4 -0.6 -0.3 -0.5
Ever taken oral contraceptive pill 0.1 0.2 0.4 0.6 -0.2 -0.2
Hearing aid user 1.4 1.6 2.1 -0.8 1.5 1.4
Mother’s age at death 1.4 1.7 4.2 2.0 0.4 0.9
Financial situation satisfaction 2.3 2.8 4.9 0.8 -1.7 -2.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 -0.2 -0.5 -0.2
Commuting to job workplace: Public transport 1.5 1.8 3.0 -1.1 1.1 1.7
Eye problems/disorders: Glaucoma 0.9 1.1 1.8 -0.4 1.1 1.3
Medication: Blood pressure 2.1 4.0 9.7 -0.6 1.4 3.1
Pain type(s) experienced in last month: Hip pain 2.9 3.7 4.7 -2.2 1.5 2.0
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 -0.6 -0.3 0.3
High cholesterol (Self-reported) 0.6 1.1 1.4 0.9 -1.2 -1.0
Medication: Bendroflumethiazide 0.1 0.1 0.4 0.1 -0.1 0.6
Medication: Paracetamol 1.2 1.8 3.5 1.9 -1.2 -0.7
Medication: Lisinopril 1.1 1.5 2.8 1.0 -1.7 -0.8
Medication: Atorvastatin 1.1 1.3 1.8 -0.9 1.2 1.3
Illnesses of father: High blood pressure 0.6 0.7 1.3 0.9 -0.2 1.1
Alcohol drinker status: Never 0.7 0.8 2.0 -1.4 0.3 0.5
Ever smoked 0.5 0.9 1.3 1.1 -0.8 -1.0
Basal metabolic rate 1.0 5.5 10.0 -1.9 1.7 3.2
Leg fat percentage (left) 2.6 9.3 9.6 -3.0 3.1 3.1
Arm fat-free mass (left) 0.8 3.9 6.1 -2.1 1.1 2.5
Number of operations (self-reported) 1.8 2.7 4.4 -1.4 2.1 1.4
Average weekly beer plus cider intake 3.3 4.8 7.7 0.1 2.8 2.6
Irritability 0.5 0.8 1.9 0.4 0.6 1.4
Risk taking 0.0 0.1 0.1 0.3 0.1 -0.4
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.1 0.1 -0.4 -0.1
Fractured/broken bones in last 5 years 1.0 1.3 3.1 0.4 -0.8 -1.8
Age started oral contraceptive pill 1.6 2.0 3.7 0.3 -1.5 -1.9
Diastolic blood pressure, automated reading 0.0 0.1 0.2 -0.2 0.4 0.3
Ever depressed for a whole week 1.1 1.4 1.9 1.4 -1.3 -0.8
Unable to work because of sickness or disability 0.2 0.2 0.2 0.5 0.4 0.5
Commuting to job workplace: Cycle 0.8 1.0 1.6 0.6 -1.3 -1.1
Myopia 1.4 2.0 4.2 2.1 -1.0 -0.9
Vascular/heart problems diagnosed by doctor 1.0 2.6 4.2 2.0 -0.3 -1.9
Cholesterol lowering medication 0.1 0.1 0.2 -0.2 0.1 0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.9 -0.1 -1.0 -0.2
Pain experienced in last month 0.6 1.0 1.3 0.9 -1.1 -1.0
Supplements: Calcium 0.2 0.2 0.7 0.2 -0.8 -0.1
Basal cell carcinoma (self-reported) 0.5 0.6 0.9 -0.3 0.9 0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 0.0 0.4 1.1
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.6 0.3 -1.2 -1.3
Heart disease (siblings) 0.2 0.2 0.3 -0.5 -0.5 -0.5
Alcohol drinker status: Previous 0.5 0.6 1.3 -0.6 -1.1 -0.4
Pack years of smoking 0.5 0.7 1.3 -0.5 0.9 1.1
Impedance of whole body 0.5 2.5 3.8 1.9 -0.9 -1.7
Leg fat mass (left) 2.3 9.0 10.6 -2.8 2.9 3.3
Arm predicted mass (left) 0.9 4.5 7.3 -2.1 1.2 2.7