Hub : Genes

TDRD7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0760	0.0360	0.00290	-0.003	NA	-0.003	NA	-0.002	9.7e-01	NA	8.7e-01	NA	6.0e-01
2	YFS	Blood	0.0257	0.0094	0.00012	0.015	0.01	0.012	0.012	0.011	6.3e-06	0.0003	7.6e-05	6.4e-05	9.1e-05
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0340	0.0173	0.00075	0.032	0.02	0.017	NA	0.024	1.6e-04	0.0021	4.6e-03	NA	8.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	1.2	1.1	-1.0	-0.8
Bipolar Disorder or Schizophrenia	0.5	1.3	2.1	0.5	-1.4	-1.3
Depressed Affect (Nagel 2018)	0.3	0.7	1.4	-0.4	0.7	1.2
Depression (Nagel 2018)	0.1	0.2	0.6	0.2	-0.7	-0.3
Intelligence (Savage-Jansen 2018)	1.4	4.3	5.6	-1.7	2.1	2.4
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.4	-0.2	0.8
Schizophrenia (2018)	0.4	0.7	1.2	-0.3	-1.1	-1.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	-0.0	0.2	0.3
Worry (Nagel 2018)	0.6	1.3	2.5	1.6	0.1	1.1
Alzheimer’s Disease (in mother)	0.8	1.0	1.1	-1.0	1.1	0.9
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	0.4	0.2
Alzheimer’s Disease (including proxy)	1.2	1.7	2.1	-1.3	1.4	1.1
Crohns Disease (2017)	0.1	0.1	0.2	-0.3	-0.3	-0.5
Irritable Bowel Disease (IBD)	0.4	1.0	1.8	1.3	-0.7	-0.9
Ulcerative Colitis (UC)	1.5	2.8	6.9	2.6	-0.6	-1.0
Major Depression (MDD)	0.5	0.6	1.1	1.1	0.3	0.7
Reaction Time	0.3	0.5	1.0	-0.5	-1.0	0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.0	-0.9	1.2	1.7
Breast Cancer	0.3	0.8	1.3	0.6	-1.1	-0.9
Ovarian Cancer	0.5	0.6	1.7	-1.3	0.2	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.6	2.3	3.4	1.8	-1.5	-1.1
Bipolar Disorder (2011)	1.7	1.6	2.8	0.5	-1.7	-1.4
Body Mass Index (BMI) (2010)	1.3	1.8	3.9	0.0	-1.2	-2.0
Coronary Artery Disease (CAD)	3.4	4.1	5.7	-1.4	2.2	2.4
Crohns Disease (2012)	0.1	0.2	0.3	-0.2	0.5	0.6
Mean Putamen Volume	0.1	0.1	0.1	-0.1	0.3	0.3
Fasting Glucose	2.0	2.3	6.3	-2.5	-0.2	0.8
HbA1C	5.6	6.2	13.6	3.7	-1.7	-1.5
HDL Cholesterol	0.1	0.1	0.2	-0.2	0.5	0.2
LDL Cholesterol	0.1	0.2	0.3	0.4	-0.3	-0.5
Lupus	0.2	0.2	0.3	0.6	0.1	-0.6
Neuroticism (2016)	0.1	0.1	0.2	0.2	-0.5	-0.3
Primary Biliary Cirrhosis	1.5	2.2	4.2	0.4	-1.5	-2.0
Rheumatoid Arthritis	0.4	0.6	0.6	-0.8	0.8	0.7
Schizophrenia (2014)	0.4	1.0	1.6	-0.2	-1.1	-1.2
Triglycerides	0.5	0.9	0.9	0.9	0.9	1.0
Type 2 Diabetes (T2D) (2012)	2.4	2.8	3.6	1.5	-1.6	-1.9
Ulcerative Colitis	0.5	0.7	1.7	1.3	-0.4	-0.5
Blood Eosinophil Count	0.0	0.3	0.5	0.5	-0.7	0.1
Blood Platelet Count	1.2	13.8	29.8	3.2	-1.1	-5.5
Blood Red Count	0.0	0.2	0.5	-0.1	-0.2	0.7
Blood White Count	0.4	2.7	6.8	-2.6	1.1	-0.1
Heel T-Score	0.1	0.9	1.1	1.0	-0.7	-1.1
BMI	0.3	1.9	4.1	-2.0	1.2	0.5
Height	0.2	3.1	9.0	0.6	-0.1	3.0
Waist Hip Ratio (WHR)	0.4	1.9	2.0	1.2	1.4	1.4
Systolic Blood Pressure	0.2	0.9	1.6	0.4	-1.3	-0.9
Smoking Status	0.1	0.2	0.4	-0.0	-0.4	-0.6
Allergy or Eczema	0.3	0.7	1.8	-1.3	0.1	0.5
Cardiovascular Disease	0.1	0.4	0.6	-0.6	-0.2	0.8
Hypothyroidism (self reported)	0.7	1.6	3.6	-0.7	1.9	-0.9
Respiratory disease	0.6	1.2	2.1	0.4	-1.2	-1.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.7	0.1	0.2
Lung FEV1/FVC ratio	0.4	1.9	2.0	-1.3	-1.4	1.4
Lung FVC	0.4	1.9	4.4	0.6	-0.9	-2.1
Neuroticism	0.5	1.3	2.9	-0.1	0.9	1.7
Chronotype (morning person)	5.5	12.8	19.3	2.3	-4.4	-3.7
Hair Pigment	0.0	0.5	1.2	1.1	0.0	-0.5
Tanning	0.0	0.2	0.3	0.2	0.4	0.6
Hand grip strength (left)	2.4	6.2	9.2	2.4	-2.0	-3.0
Number of treatments/medications taken	0.3	0.6	1.1	-0.5	0.6	1.1
Average weekly spirits intake	1.2	1.4	1.5	1.2	-1.2	-1.2
Sensitivity / hurt feelings	0.4	0.7	0.8	0.9	-0.7	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.1	-0.5	-0.2
Hearing difficulty/problems: Yes	0.7	1.0	3.0	-1.7	-0.2	0.2
Relative age of first facial hair	0.4	0.8	2.1	1.4	-0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	-0.3	0.5	1.5
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.5	-1.1	-1.0	-1.6
Ever had hysterectomy (womb removed)	0.2	0.3	0.8	0.9	-0.1	-0.1
Systolic blood pressure, automated reading	0.0	0.0	0.0	-0.2	-0.2	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.1	-0.3	0.7	1.1
Angina	0.2	0.2	0.4	-0.5	0.2	0.6
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.1	-0.8	-0.6
Vitamin and mineral supplements	1.2	1.6	3.1	-0.4	1.8	1.2
Supplements: Zinc	0.3	0.3	0.6	0.8	-0.4	-0.3
Medication: Co-codamol	0.2	0.3	0.3	-0.6	0.5	0.4
Medication: Metformin	0.2	0.2	0.5	-0.7	0.1	0.5
Diabetes (father)	0.2	0.3	0.5	-0.2	-0.6	-0.7
Diabetes (mother)	0.9	1.1	2.4	-0.6	0.7	1.6
Severe depression (siblings)	0.1	0.1	0.3	0.5	0.0	0.0
Pack years adult smoking proportion	0.7	1.0	1.7	-0.5	1.1	1.3
Impedance of leg (right)	0.3	1.7	4.0	0.6	-0.8	-2.0
Leg fat-free mass (left)	1.0	5.3	10.4	-1.5	1.8	3.2
Trunk fat percentage	2.0	8.1	8.9	-2.8	2.7	3.0
Hand grip strength (right)	1.5	4.0	5.8	1.4	-2.1	-2.4
Townsend deprivation index at recruitment	0.9	1.3	2.1	-0.2	1.5	1.3
Current tobacco smoking	1.1	1.8	2.3	-1.3	1.5	1.2
Average weekly fortified wine intake	0.7	0.8	1.5	0.7	-1.2	-0.7
Maternal smoking around birth	0.5	0.7	1.3	-0.1	0.8	1.1
Fed-up feelings	0.5	0.9	1.6	-0.8	1.3	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	-0.3	0.2	0.3
Relative age voice broke	1.6	2.4	4.3	2.1	-1.4	-1.1
Taking other prescription medications	0.6	1.0	1.9	-1.4	0.7	0.8
Age when periods started (menarche)	0.4	1.0	2.9	1.7	-0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.4	-0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.2	0.9	-1.1	-0.3
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	4.3	2.1	-0.6	-0.9
Qualifications: CSEs or equivalent	0.8	1.1	1.8	-0.2	1.2	1.3
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.5	-0.5	-0.6
High blood pressure	1.1	2.9	5.6	-2.4	0.2	1.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.5	-1.9	0.2	0.5
Multivitamins +/- minerals	0.8	1.0	1.8	0.3	-1.3	-1.1
Stomach or abdominal pain in last month	0.8	1.0	1.8	0.3	1.3	1.1
Supplements: Glucosamine	0.6	0.7	1.5	-1.2	-0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	-1.3	0.9	0.1
Medication: Atenolol	0.4	0.5	1.0	0.2	0.6	1.0
Medication: Levothyroxine sodium	1.3	2.2	5.1	-1.1	2.2	-0.5
Sitting height	0.3	2.1	5.2	0.0	1.0	2.3
Chronic bronchitis/emphysema (father)	0.8	1.0	1.7	-1.1	1.3	0.2
High blood pressure (mother)	2.2	3.1	9.0	3.0	-0.5	-0.2
Body mass index (BMI)	1.8	7.6	8.6	-2.9	2.5	2.9
Impedance of leg (left)	0.5	2.4	4.4	1.4	-1.0	-2.1
Leg predicted mass (left)	1.0	5.2	10.2	-1.4	1.8	3.2
Trunk fat mass	2.4	10.3	12.5	-3.2	2.9	3.5
Waist circumference	1.9	7.1	11.2	-1.9	2.5	3.4
Number of incorrect matches in round	1.1	1.8	2.5	1.0	-1.6	-1.3
Past tobacco smoking	0.2	0.3	0.6	-0.7	0.3	0.6
Alcohol usually taken with meals	8.0	13.0	21.9	1.2	-3.9	-4.7
Nervous feelings	0.1	0.2	0.6	-0.1	0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	0.4	-1.3	-0.8
Hearing difficulty/problems with background noise	1.0	1.5	2.0	-1.2	-1.4	-1.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	0.4	0.1
Had menopause	0.9	1.1	2.1	-1.4	-1.1	-0.1
Had other major operations	2.0	2.4	5.0	-2.2	0.7	1.3
Forced vital capacity (FVC)	0.2	0.9	1.6	1.2	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	0.2	-1.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.1	0.8	-1.1	-0.8
Qualifications: None of the above	0.1	0.1	0.2	0.3	0.3	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.8	0.5	0.9	-0.0
Mouth/teeth dental problems	2.6	4.0	8.2	0.4	-1.9	-2.9
Heart attack	0.4	0.5	1.3	-0.1	0.5	1.2
Allergy	0.2	0.5	1.2	1.1	0.4	0.4
Pain all over the body in last month	1.0	1.0	2.0	-0.2	-1.0	-1.4
Diabetes (self-reported)	0.1	0.2	0.4	0.2	0.2	0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	-0.4	-0.6	-0.2
Medication: Ramipril	1.4	1.8	3.9	-0.7	0.9	2.0
Medication: Simvastatin	0.2	0.3	0.7	0.2	-0.8	-0.3
Fluid intelligence score	1.7	3.6	6.0	-1.2	1.8	2.4
Illnesses of siblings	0.0	0.0	0.1	-0.2	0.2	-0.1
Neuroticism score	0.6	1.3	2.7	-0.0	1.1	1.6
Weight	1.8	8.7	12.6	-2.8	2.4	3.5
Impedance of arm (right)	0.5	2.3	4.0	2.0	-0.9	-1.5
Arm fat percentage (right)	1.8	7.0	7.6	-2.8	2.5	2.7
Trunk fat-free mass	0.6	3.5	6.4	-1.8	1.0	2.5
Hip circumference	1.5	6.4	10.1	-2.3	1.9	3.2
Time employed in main current job	0.8	1.0	1.9	-0.7	-1.4	-0.7
Alcohol intake versus 10 years previously	0.5	0.7	1.3	-0.5	0.8	1.1
Father’s age at death	0.0	0.1	0.2	-0.1	0.2	0.4
Worrier / anxious feelings	0.2	0.3	0.8	-0.4	0.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.2	0.8	-0.1
Falls in the last year	3.2	4.3	8.3	-0.2	-2.1	-2.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.0	-0.5	-0.8
Number of live births	0.3	0.5	0.7	-0.4	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.1	0.7	-1.0	-0.1
Pulse rate	1.4	2.4	3.7	-0.0	1.8	1.9
Happiness	0.3	0.4	0.9	-0.9	0.4	-0.3
Noisy workplace	0.9	1.2	1.8	-1.3	1.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.8	-0.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.4	-0.3	-1.5	-0.8
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.2	0.5	0.4
Asthma	0.2	0.3	0.5	0.2	-0.6	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.3	0.7	0.4
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	-0.4	-0.1
Depression (self-reported)	1.4	1.6	2.7	-0.5	1.4	1.6
Medication: Lansoprazole	0.8	0.9	2.2	1.5	-0.7	0.2
Prospective memory result	0.4	0.4	0.8	0.1	-0.9	-0.7
Lung cancer (father)	0.6	0.7	1.2	-0.8	1.1	0.6
Illnesses of mother	0.9	1.1	2.9	-1.7	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.1	1.1	-0.9	-0.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.4	0.6	-0.6	-0.3
Impedance of arm (left)	0.3	1.5	3.0	1.7	-0.7	-1.1
Arm fat mass (right)	2.1	8.7	11.1	-2.8	2.7	3.3
Trunk predicted mass	0.6	3.5	6.3	-1.8	1.0	2.5
Standing height	0.1	1.5	4.3	-0.2	0.3	2.1
Length of working week for main job	0.3	0.4	0.9	-1.0	0.3	0.3
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.3	0.3	0.7
Breastfed as a baby	0.9	1.1	1.4	-1.0	-1.2	-0.9
Tense / ‘highly strung’	0.8	1.3	2.3	-0.0	1.2	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.0	0.9	0.6	1.0
Hair/balding pattern: Pattern 4	0.3	0.6	1.3	1.1	-0.4	-0.7
Birth weight of first child	0.2	0.4	1.3	-0.1	1.1	0.1
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.1	-0.7	-0.5
Pulse wave reflection index	1.3	1.6	2.4	1.1	-1.5	-1.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.1	-0.6	0.5
Loud music exposure frequency	0.5	0.5	1.5	1.2	0.3	-0.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.4	-0.3	-1.2	-0.8
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.8	0.1	1.5	1.9
Blood clot in the leg (DVT)	0.9	1.1	2.1	0.3	-1.1	-1.4
Medication: Paracetamol	0.3	0.5	1.3	1.2	-0.4	-0.1
Headache pain in last month	0.7	1.2	1.8	-1.3	0.7	1.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.4	1.5	0.2	-1.2
Glaucoma (self-reported)	1.4	1.6	2.5	-0.6	1.4	1.6
Gout (self-reported)	0.7	1.0	2.5	0.4	-0.5	-1.6
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.8	-0.2	2.4	-0.5
Medication: Amlodipine	0.6	0.8	2.2	0.0	0.5	1.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.5	1.6	0.7	0.3
Birth weight	0.1	0.3	0.6	0.8	-0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.6	0.8	0.8	-0.2
High blood pressure (siblings)	0.4	0.6	1.0	0.7	0.6	1.0
Forced vital capacity (FVC), Best measure	0.4	1.6	3.4	1.8	-0.9	-0.7
Body fat percentage	2.2	8.6	8.9	-3.0	2.9	3.0
Leg fat percentage (right)	2.9	10.5	12.9	-3.6	3.1	3.0
Arm fat-free mass (right)	0.9	4.5	7.4	-2.1	1.3	2.7
Exposure to tobacco smoke outside home	3.0	4.0	7.7	-0.3	2.1	2.8
Comparative body size at age 10	0.6	1.7	3.0	-1.7	1.1	1.0
Number of full brothers	1.2	1.5	2.0	-0.9	1.4	1.3
Worry too long after embarrassment	0.1	0.1	0.2	0.0	-0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.2	0.8	0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	0.8	-0.1	-0.5
Number of children fathered	0.9	1.0	1.8	0.7	-1.3	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-0.3	-0.9	-1.2
Age at first live birth	3.1	5.4	7.5	2.7	-2.1	-2.1
Pulse wave peak to peak time	0.3	0.4	0.4	-0.6	0.6	0.6
Health satisfaction	0.5	0.7	1.1	-1.0	-0.1	-0.9
Shortness of breath walking on level ground	0.3	0.4	0.6	0.5	0.5	0.8
Qualifications: College or University degree	0.3	1.0	1.9	-0.2	-1.4	-1.0
Eye problems/disorders: None of the above	0.6	0.7	1.5	0.7	-0.3	-1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	0.9	-0.1	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.5	0.3	0.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.0	0.2	-0.6
Neck or shoulder pain in last month	2.7	3.8	6.3	-0.5	2.5	2.2
Medication: Blood pressure	1.3	2.2	5.5	-2.3	-0.5	1.0
Angina (self-reported)	0.3	0.4	0.8	-0.6	0.5	0.9
Migraine (self-reported)	0.1	0.1	0.2	-0.4	-0.4	-0.1
Medication: Ibuprofen	0.2	0.3	0.7	0.8	-0.1	-0.4
Medication: Allopurinol	0.2	0.3	0.6	-0.8	-0.3	-0.6
Medication: Omeprazole	0.5	0.6	1.3	-0.4	-1.1	-0.6
Medication: Seretide 50 evohaler	0.7	0.8	1.0	-0.7	1.0	1.0
Mean time to correctly identify matches	0.7	1.2	2.6	-1.6	-0.8	0.7
Heart disease (mother)	0.0	0.0	0.0	-0.0	0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.6	-0.6	0.6	0.8
Whole body fat mass	2.2	9.3	10.8	-3.0	2.8	3.3
Leg fat mass (right)	2.6	9.9	10.8	-3.2	2.9	3.3
Arm predicted mass (right)	0.8	4.1	6.4	-2.1	1.2	2.5
Pulse rate, automated reading	0.7	2.4	4.0	-2.0	1.2	1.3
Alcohol intake frequency.	0.5	1.1	2.7	-1.6	-0.6	0.5
Comparative height size at age 10	0.1	0.6	1.3	-0.3	-0.5	1.1
Number of full sisters	0.3	0.3	0.7	0.2	0.5	0.8
Suffer from ‘nerves’	0.2	0.2	0.7	0.2	0.1	0.8
Overall health rating	0.4	0.8	1.6	-1.3	0.7	0.5
Chest pain or discomfort	0.5	0.8	1.2	-1.0	0.3	1.1
Had major operations	0.7	0.8	2.4	0.1	1.5	0.2
Age at last live birth	4.1	6.0	7.6	2.8	-2.3	-2.3
Family relationship satisfaction	0.9	1.1	2.3	0.2	1.5	0.9
Leg pain on walking	0.8	1.0	1.5	-0.2	-1.1	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-0.2	1.1	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.3	0.5	-0.3	-1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.0	-1.0	1.0	0.6
Medication: Aspirin	1.1	1.5	3.6	0.2	0.9	1.9
Supplements: Vitamin C	0.2	0.3	0.5	0.3	-0.4	0.7
Knee pain experienced in last month	1.9	3.0	3.5	-1.7	1.5	1.9
Hypertension (Self-reported)	0.8	2.2	3.7	-1.9	0.4	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.8	0.5	-0.9	-0.8
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.9	0.2	0.2
Illnesses of siblings: Diabetes	0.2	0.3	0.3	0.6	-0.5	-0.5
Smoking status: Previous	0.4	0.7	0.9	0.9	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.6	-0.5	-1.0	-1.2
Whole body fat-free mass	0.8	4.4	8.3	-1.7	1.4	2.9
Leg fat-free mass (right)	0.8	4.2	9.3	-1.0	1.6	3.0
Arm fat percentage (left)	2.4	9.4	10.0	-3.1	2.9	3.2
Average weekly red wine intake	0.9	1.3	1.5	-1.2	-1.1	-1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	1.3	-0.3	-0.2
Mood swings	0.1	0.2	0.3	-0.3	0.5	0.5
Loneliness, isolation	1.0	1.3	2.2	0.7	1.5	1.1
Long-standing illness, disability or infirmity	1.0	1.5	3.8	-1.9	0.5	0.8
Ever had bowel cancer screening	0.1	0.2	0.4	-0.7	0.2	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.4	-0.0	0.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.2	0.5	-0.7
Friendships satisfaction	0.1	0.1	0.3	-0.1	0.6	-0.1
Qualifications: nursing, teaching	0.2	0.2	0.5	-0.4	-0.7	-0.3
Commuting to job workplace: Walk	0.9	0.9	1.8	0.0	1.0	1.4
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.7	-0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	4.9	-0.5	1.8	2.2
Medication for cholesterol	1.1	1.6	3.8	0.5	-0.9	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.4	0.0
Back pain experienced in last month	0.0	0.0	0.1	0.2	-0.2	-0.1
Mineral and other dietary supplements	0.7	0.9	2.4	0.3	1.5	0.4
Breast cancer (self-reported)	0.1	0.2	0.3	0.0	0.6	0.3
Asthma (self-reported)	0.1	0.2	0.4	0.4	-0.4	-0.6
Osteoporosis (self-reported)	1.1	1.3	2.9	0.2	-1.0	-1.7
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.7	-0.1	0.6
Medication: Aspirin	0.8	1.1	2.7	0.4	0.7	1.6
Medication: Gliclazide	0.2	0.2	0.4	-0.2	-0.5	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.7	2.0	1.4	0.2	0.2
Smoking status: Current	1.0	1.7	2.2	-1.2	1.5	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-1.0	0.0	0.6
Whole body water mass	0.7	4.2	8.1	-1.6	1.3	2.8
Leg predicted mass (right)	0.8	4.2	9.4	-0.9	1.6	3.1
Arm fat mass (left)	2.4	9.9	11.9	-3.1	2.9	3.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.8	-0.5	-0.2
Average weekly champagne plus white wine intake	1.4	1.9	3.0	0.7	-1.7	-1.4
Miserableness	1.1	1.9	3.5	-0.5	1.4	1.9
Guilty feelings	0.3	0.5	1.0	-1.0	-0.6	0.0
Wears glasses or contact lenses	0.2	0.3	0.4	-0.6	-0.3	-0.5
Ever taken oral contraceptive pill	0.1	0.2	0.4	0.6	-0.2	-0.2
Hearing aid user	1.4	1.6	2.1	-0.8	1.5	1.4
Mother’s age at death	1.4	1.7	4.2	2.0	0.4	0.9
Financial situation satisfaction	2.3	2.8	4.9	0.8	-1.7	-2.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.2	-0.5	-0.2
Commuting to job workplace: Public transport	1.5	1.8	3.0	-1.1	1.1	1.7
Eye problems/disorders: Glaucoma	0.9	1.1	1.8	-0.4	1.1	1.3
Medication: Blood pressure	2.1	4.0	9.7	-0.6	1.4	3.1
Pain type(s) experienced in last month: Hip pain	2.9	3.7	4.7	-2.2	1.5	2.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.6	-0.3	0.3
High cholesterol (Self-reported)	0.6	1.1	1.4	0.9	-1.2	-1.0
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.1	-0.1	0.6
Medication: Paracetamol	1.2	1.8	3.5	1.9	-1.2	-0.7
Medication: Lisinopril	1.1	1.5	2.8	1.0	-1.7	-0.8
Medication: Atorvastatin	1.1	1.3	1.8	-0.9	1.2	1.3
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.9	-0.2	1.1
Alcohol drinker status: Never	0.7	0.8	2.0	-1.4	0.3	0.5
Ever smoked	0.5	0.9	1.3	1.1	-0.8	-1.0
Basal metabolic rate	1.0	5.5	10.0	-1.9	1.7	3.2
Leg fat percentage (left)	2.6	9.3	9.6	-3.0	3.1	3.1
Arm fat-free mass (left)	0.8	3.9	6.1	-2.1	1.1	2.5
Number of operations (self-reported)	1.8	2.7	4.4	-1.4	2.1	1.4
Average weekly beer plus cider intake	3.3	4.8	7.7	0.1	2.8	2.6
Irritability	0.5	0.8	1.9	0.4	0.6	1.4
Risk taking	0.0	0.1	0.1	0.3	0.1	-0.4
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.1	-0.4	-0.1
Fractured/broken bones in last 5 years	1.0	1.3	3.1	0.4	-0.8	-1.8
Age started oral contraceptive pill	1.6	2.0	3.7	0.3	-1.5	-1.9
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.2	0.4	0.3
Ever depressed for a whole week	1.1	1.4	1.9	1.4	-1.3	-0.8
Unable to work because of sickness or disability	0.2	0.2	0.2	0.5	0.4	0.5
Commuting to job workplace: Cycle	0.8	1.0	1.6	0.6	-1.3	-1.1
Myopia	1.4	2.0	4.2	2.1	-1.0	-0.9
Vascular/heart problems diagnosed by doctor	1.0	2.6	4.2	2.0	-0.3	-1.9
Cholesterol lowering medication	0.1	0.1	0.2	-0.2	0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	-0.1	-1.0	-0.2
Pain experienced in last month	0.6	1.0	1.3	0.9	-1.1	-1.0
Supplements: Calcium	0.2	0.2	0.7	0.2	-0.8	-0.1
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	-0.3	0.9	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	0.0	0.4	1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.6	0.3	-1.2	-1.3
Heart disease (siblings)	0.2	0.2	0.3	-0.5	-0.5	-0.5
Alcohol drinker status: Previous	0.5	0.6	1.3	-0.6	-1.1	-0.4
Pack years of smoking	0.5	0.7	1.3	-0.5	0.9	1.1
Impedance of whole body	0.5	2.5	3.8	1.9	-0.9	-1.7
Leg fat mass (left)	2.3	9.0	10.6	-2.8	2.9	3.3
Arm predicted mass (left)	0.9	4.5	7.3	-2.1	1.2	2.7