Hub : Genes

TEAD2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0970 0.0260 6.5e-08 0.080 0.054 0.047 0.055 0.071 5.3e-10 3.6e-07 2.2e-06 3e-07 5.9e-09
2 GTEx Brain Caudate basal ganglia 0.3510 0.1040 3.7e-04 -0.007 NA -0.008 NA -0.007 5.5e-01 NA 6.4e-01 NA 5.8e-01
3 GTEx Brain Hippocampus 0.2974 0.1225 6.2e-03 0.003 NA 0.014 NA 0.001 2.7e-01 NA 1.5e-01 NA 3.0e-01
4 GTEx Brain Nucleus accumbens basal ganglia 0.3550 0.0940 5.2e-05 0.237 NA 0.172 NA 0.226 5.1e-07 NA 2.3e-05 NA 1.0e-06
5 GTEx Cells Transformed fibroblasts 0.1500 0.0560 1.7e-03 -0.004 NA 0.031 NA -0.001 8.2e-01 NA 2.2e-03 NA 4.3e-01
6 GTEx Esophagus Mucosa 0.0700 0.0290 4.3e-03 0.050 NA 0.024 NA 0.036 3.0e-04 NA 8.9e-03 NA 1.8e-03
7 GTEx Muscle Skeletal 0.1200 0.0336 1.1e-06 0.074 NA 0.027 NA 0.043 9.0e-08 NA 9.6e-04 NA 4.5e-05
8 YFS Blood 0.0755 0.0146 0.0e+00 0.110 0.103 0.112 0.113 0.116 4.3e-34 8.6e-32 8.4e-35 6e-35 7.4e-36
9 TCGA Bladder Urothelial Carcinoma 0.0310 0.0240 6.0e-03 0.007 0.014 0.010 NA 0.019 7.7e-02 2.1e-02 4.1e-02 NA 8.9e-03
10 TCGA Head and Neck Squamous Cell Carcinoma 0.0293 0.0202 1.1e-03 0.011 0.022 0.015 NA 0.012 1.8e-02 1.5e-03 7.8e-03 NA 1.4e-02
11 TCGA Brain Lower Grade Glioma 0.0331 0.0197 2.5e-04 0.031 0.034 0.036 NA 0.037 1.7e-04 9.4e-05 5.8e-05 NA 4.7e-05
12 TCGA Thyroid Carcinoma 0.0340 0.0220 4.7e-04 0.046 0.026 0.030 NA 0.031 2.6e-05 1.3e-03 5.6e-04 NA 4.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.3 0.5 1.5 -0.8 -1.0 1.2 -0.7 0.8 0.4 -0.8 -0.2 0.2 0.2 -0.7 -0.3
Bipolar Disorder or Schizophrenia 0.1 0.2 0.9 -0.0 -0.8 -0.1 -0.1 0.7 0.7 -0.0 0.9 -0.0 0.5 0.1 0.4
Depressed Affect (Nagel 2018) 4.3 9.1 13.8 -3.6 -1.2 0.5 -3.2 2.4 3.7 -3.4 2.8 3.6 3.5 -3.6 2.9
Depression (Nagel 2018) 1.1 1.6 4.0 -0.6 0.5 0.9 -0.2 0.8 2.0 -0.4 2.0 1.4 1.6 -0.7 2.0
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.2 -0.4 -0.3 -0.8 -0.3 -0.1 -0.7 -0.3 -1.1 -0.4 -0.7 -0.1 -0.9
Neuroticism (Nagel 2018) 1.2 2.8 6.6 -1.1 0.3 0.8 -1.1 2.1 2.0 -1.0 2.6 1.8 2.0 -1.6 2.1
Schizophrenia (2018) 0.2 0.5 1.9 0.6 -0.2 -1.2 0.5 0.3 0.6 0.6 1.4 -0.2 0.4 0.7 0.7
Schizophrenia vs Biploar Disorder 0.4 0.6 1.4 1.1 -0.0 -0.4 1.2 -0.9 -1.0 0.9 -0.3 -0.6 -0.6 0.9 -0.1
Worry (Nagel 2018) 0.3 0.6 1.3 -0.5 -0.2 0.4 -0.1 1.0 0.9 -0.5 1.0 1.0 0.9 -0.6 1.2
Alzheimer’s Disease (in mother) 1.8 2.1 4.0 -2.0 -1.2 -0.5 -1.8 0.9 1.6 -1.9 0.7 1.6 1.4 -1.9 0.9
Alzheimer’s Disease (in father) 0.2 0.2 0.7 -0.5 0.1 0.0 -0.3 0.6 0.4 -0.4 0.4 0.6 0.6 -0.5 0.8
Alzheimer’s Disease (including proxy) 1.0 1.5 2.5 -1.3 -0.4 0.6 -1.2 1.1 1.6 -1.2 1.4 1.3 1.4 -1.4 1.2
Crohns Disease (2017) 0.3 0.7 2.4 -0.8 -0.5 -0.1 -1.1 1.5 0.1 -0.9 -0.0 1.0 0.5 -1.0 0.6
Irritable Bowel Disease (IBD) 0.2 0.5 3.9 -0.3 -0.4 0.7 -0.3 2.0 -0.6 -0.5 -0.8 0.2 -0.2 -0.3 -0.1
Ulcerative Colitis (UC) 0.3 0.5 3.7 -0.1 -0.6 1.0 0.1 1.9 -0.5 -0.3 -0.9 0.1 -0.4 -0.1 -0.4
Major Depression (MDD) 0.2 0.3 0.7 -0.9 -0.2 -0.2 -0.9 0.0 0.4 -0.8 -0.1 0.4 0.5 -0.2 0.7
Reaction Time 1.0 1.8 8.1 0.6 2.8 2.7 0.4 -0.2 -0.5 0.7 -0.7 -1.4 -0.9 1.0 -1.1
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.6 0.4 -0.0 -0.5 0.5 -0.8 -0.5 0.6 -0.4 -0.2 -0.6 0.3 -0.4
Breast Cancer 0.9 2.2 7.5 1.8 0.7 2.7 1.8 -1.6 -0.8 1.6 -0.1 -1.5 -0.9 1.7 -0.3
Ovarian Cancer 0.2 0.3 0.9 0.6 0.3 -0.2 0.3 -0.1 -0.8 0.6 -0.5 -0.4 -0.7 0.1 -0.9
Prostate Cancer 0.3 0.4 1.4 0.8 0.7 -0.6 0.3 0.1 0.4 0.6 1.2 -0.0 0.4 0.5 0.8
Age at First Birth 0.5 0.7 3.6 0.7 1.9 0.8 0.7 -0.3 -0.6 0.7 -0.3 -0.8 -0.5 0.8 -0.5
Bipolar Disorder (2011) 0.1 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.5 -0.4 0.7
Body Mass Index (BMI) (2010) 1.4 1.9 4.1 1.8 1.0 1.2 1.8 -0.8 -0.9 2.0 0.0 -1.5 -1.1 2.0 -0.5
Coronary Artery Disease (CAD) 0.1 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.6 -0.5 -0.1 -1.0
Crohns Disease (2012) 0.1 0.2 1.1 0.1 -0.0 0.4 0.0 -0.0 -0.8 -0.1 -1.0 -0.4 -0.5 -0.2 -0.7
Mean Putamen Volume 0.3 0.3 2.6 0.1 -1.6 -0.2 -0.1 -0.1 0.2 -0.1 0.6 0.0 0.4 0.3 0.7
Fasting Glucose 1.5 1.8 2.9 -1.7 -1.7 -0.8 -1.0 0.3 1.7 -1.5 1.1 1.6 1.4 -1.0 1.3
HbA1C 0.1 0.2 0.7 -0.5 -0.3 -0.4 -0.2 -0.9 -0.1 -0.6 -0.0 -0.2 0.1 -0.2 -0.6
HDL Cholesterol 0.2 0.3 1.4 -0.2 -0.1 -0.2 -0.5 -0.5 -0.5 -0.3 -1.2 -0.4 -0.5 -0.2 -0.8
LDL Cholesterol 0.4 0.6 1.3 -0.7 -1.0 -0.5 -0.3 0.2 0.7 -0.6 0.9 1.1 0.9 -0.7 1.0
Lupus 1.5 2.2 5.8 1.9 2.0 1.8 2.4 -1.1 0.1 1.9 0.9 -0.5 -0.3 1.8 0.8
Neuroticism (2016) 0.3 0.4 0.7 0.5 0.8 0.6 0.5 -0.8 -0.7 0.6 -0.5 -0.2 -0.8 0.3 -0.8
Primary Biliary Cirrhosis 0.7 1.0 2.6 1.6 0.4 1.1 1.4 -0.2 -0.2 1.4 0.4 -1.1 -0.6 1.4 -0.0
Rheumatoid Arthritis 1.0 1.4 4.7 1.1 1.6 1.1 1.2 -2.2 -0.9 1.1 -1.0 -0.3 -0.7 1.1 -0.2
Schizophrenia (2014) 0.1 0.2 0.5 0.3 -0.7 -0.7 0.5 0.1 0.2 0.3 0.5 -0.1 0.1 0.4 0.3
Triglycerides 0.1 0.2 1.1 -0.4 -0.3 1.1 -0.3 0.8 0.3 -0.3 0.6 0.1 0.4 -0.2 0.1
Type 2 Diabetes (T2D) (2012) 1.3 1.5 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.9 -2.2 2.4 -1.9
Ulcerative Colitis 0.2 0.2 1.4 0.3 0.1 0.9 0.2 1.2 0.0 0.1 0.1 0.3 0.1 0.2 0.6
Blood Eosinophil Count 1.0 7.9 22.1 3.6 4.7 0.4 3.4 -3.7 -0.5 3.8 1.9 -1.2 -0.9 3.6 0.9
Blood Platelet Count 0.2 2.5 16.2 -1.1 0.8 0.2 -1.0 -4.0 -1.1 -1.1 -2.2 -0.7 -0.7 -0.5 -1.5
Blood Red Count 0.3 2.5 4.1 -1.6 -1.2 0.2 -2.0 2.0 2.0 -1.7 1.6 1.2 1.9 -1.6 1.3
Blood White Count 1.8 13.1 17.5 -3.9 -2.5 -4.0 -4.0 0.8 3.9 -3.7 3.2 4.2 4.1 -3.7 3.8
Heel T-Score 0.6 5.1 14.7 1.2 0.9 0.5 1.0 1.2 -3.3 1.2 -3.8 -2.6 -2.9 1.4 -3.3
BMI 0.7 3.9 18.2 1.7 2.8 4.3 2.2 -0.3 -1.0 1.8 -0.4 -1.6 -1.4 1.9 -0.9
Height 0.3 6.0 11.8 1.6 3.4 3.3 1.9 -0.9 -2.4 1.7 -2.7 -2.8 -2.6 1.8 -2.9
Waist Hip Ratio (WHR) 0.1 0.5 1.7 -0.6 -1.2 1.3 -0.2 -0.2 0.9 -0.6 0.4 0.4 0.6 -0.5 0.4
Systolic Blood Pressure 0.0 0.1 1.1 -0.1 0.2 1.0 -0.2 0.1 -0.1 0.3 -0.1 -0.3 -0.2 0.3 -0.2
Smoking Status 0.6 1.5 3.7 -0.3 -1.2 -0.5 -0.4 1.6 1.6 -0.5 1.9 1.4 1.3 -0.4 1.7
Allergy or Eczema 0.3 0.8 2.1 -0.8 0.2 1.4 -1.0 -0.8 -0.6 -0.9 -1.5 -0.4 -0.3 -0.7 -1.1
Cardiovascular Disease 1.1 3.6 22.0 1.3 1.6 4.7 1.7 -1.9 -1.0 1.5 -0.6 -1.3 -1.4 1.7 -0.9
Hypothyroidism (self reported) 1.8 4.1 9.2 -3.0 -2.6 -1.4 -2.9 -0.4 0.5 -3.0 -1.7 1.2 0.8 -2.8 -0.5
Respiratory disease 0.5 1.1 4.2 0.7 2.1 1.7 0.9 -1.8 -0.1 0.8 0.5 -0.1 0.0 0.7 0.6
Type 2 Diabetes (T2D) (2018) 0.9 1.8 3.0 1.7 1.7 0.7 1.7 -0.8 -1.0 1.6 -0.8 -1.4 -1.3 1.6 -0.8
Lung FEV1/FVC ratio 0.7 3.4 5.8 1.8 -0.2 1.4 2.0 -0.2 -2.3 1.6 -2.1 -2.1 -2.4 1.9 -2.4
Lung FVC 0.7 3.3 4.6 -1.8 0.9 -0.5 -1.9 2.0 1.8 -1.7 1.9 2.1 2.1 -2.1 2.0
Neuroticism 1.8 4.3 7.8 -1.9 0.0 0.7 -1.6 2.2 2.7 -1.7 2.8 2.5 2.5 -1.9 2.5
Chronotype (morning person) 0.5 1.2 3.2 0.3 1.8 1.6 0.5 1.6 0.9 0.4 1.4 0.5 0.8 0.2 1.5
Hair Pigment 0.0 0.2 0.8 0.4 -0.5 0.9 0.5 0.2 0.1 0.4 0.7 0.3 0.2 0.3 0.6
Tanning 0.1 0.6 1.6 -0.6 -1.0 0.0 -0.8 0.4 0.7 -0.6 0.6 1.2 0.9 -0.8 1.0
Hand grip strength (left) 0.3 0.7 5.2 0.4 0.6 1.3 0.3 2.3 0.2 0.3 0.8 -0.3 0.1 0.2 0.2
Number of treatments/medications taken 1.4 2.5 8.4 0.7 1.4 2.9 1.2 -1.1 -1.7 0.8 -1.8 -1.5 -1.7 1.0 -1.9
Average weekly spirits intake 0.7 0.9 1.7 -1.0 -0.3 0.7 -1.0 0.5 1.3 -1.1 0.5 1.1 1.0 -1.3 0.7
Sensitivity / hurt feelings 0.9 1.5 4.8 -0.5 1.5 -0.0 -0.4 2.2 1.3 -0.4 1.8 1.2 1.2 -0.6 1.6
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.3 -1.0 0.1 -0.9 -0.7 0.5 1.5 -0.8 1.5 1.4 1.4 -0.9 1.5
Hearing difficulty/problems: Yes 0.1 0.2 0.9 -0.5 -0.1 0.3 -0.2 -1.0 -0.1 -0.4 -0.2 -0.3 -0.2 -0.1 -0.5
Relative age of first facial hair 0.3 0.7 2.3 0.5 1.5 1.4 0.7 -0.3 0.2 0.3 1.2 0.1 0.3 0.5 0.9
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 0.6 0.8 1.0 0.5 -0.2 -0.5 0.7 -0.2 -0.6 -0.5 0.8 -0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.8 0.3 1.3 1.4 0.5 0.0 0.0 0.5 0.1 -0.1 -0.2 0.5 -0.1
Ever had hysterectomy (womb removed) 0.9 1.0 1.7 -1.3 -0.7 0.2 -1.3 0.6 1.3 -1.0 1.0 0.9 1.2 -0.9 1.1
Systolic blood pressure, automated reading 1.1 3.3 5.8 1.4 0.9 1.7 1.7 -0.6 -2.3 1.7 -2.0 -2.0 -2.4 2.0 -2.3
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 2.8 0.2 0.5 1.1 0.3 -0.5 1.3 0.1 1.5 0.7 1.0 0.1 1.7
Angina 0.5 0.7 2.9 -0.1 0.7 1.7 0.1 0.2 0.8 0.1 1.1 0.8 0.8 0.0 1.3
Medication for hormone replacement therapy 0.6 0.7 2.1 0.0 0.2 -0.4 0.2 -0.7 -1.1 0.2 -1.5 -1.0 -1.0 0.5 -1.2
Vitamin and mineral supplements 0.7 1.0 3.7 -0.4 -0.4 0.4 -0.3 -1.6 -0.6 -0.3 -1.4 -1.1 -1.0 -0.1 -1.9
Supplements: Zinc 1.1 1.2 3.4 1.8 1.4 -0.0 1.8 -0.2 -0.6 1.8 -0.0 -0.5 -0.7 1.4 0.0
Medication: Co-codamol 0.9 1.0 2.7 -1.0 0.2 0.2 -0.8 0.4 1.4 -0.7 1.6 1.1 1.2 -0.8 1.3
Medication: Metformin 4.0 5.6 8.5 2.7 2.7 1.7 2.6 -0.9 -2.2 2.6 -1.5 -2.9 -2.6 2.7 -2.3
Diabetes (father) 0.8 1.0 2.4 -1.0 -0.7 -1.6 -0.8 0.3 1.0 -0.8 1.0 1.1 1.1 -0.8 1.2
Diabetes (mother) 0.5 0.6 1.4 -1.0 -1.2 -0.0 -0.8 -0.7 -0.0 -1.1 -0.4 0.7 0.5 -1.1 0.4
Severe depression (siblings) 0.2 0.2 0.8 -0.1 -0.5 0.4 0.1 -0.9 -0.1 -0.2 -0.7 -0.6 -0.4 0.3 -0.5
Pack years adult smoking proportion 1.2 1.8 3.1 -1.8 -1.6 1.1 -1.5 1.1 1.3 -1.7 0.6 1.1 1.3 -1.6 0.8
Impedance of leg (right) 0.2 1.0 7.9 -0.1 -1.8 -2.8 -0.2 0.0 -0.3 -0.3 -0.3 -0.3 -0.3 -0.3 -0.8
Leg fat-free mass (left) 0.9 5.0 17.6 2.0 4.1 4.2 2.5 -0.3 -1.0 2.2 -0.2 -1.8 -1.4 2.1 -0.7
Trunk fat percentage 1.1 4.6 10.8 2.1 2.3 3.3 2.4 -0.6 -1.9 2.2 -1.1 -2.3 -2.2 2.1 -1.9
Hand grip strength (right) 0.3 0.8 6.5 0.2 0.8 1.0 0.3 2.5 0.5 0.2 0.8 -0.1 0.2 0.0 0.3
Townsend deprivation index at recruitment 2.1 2.9 4.6 1.4 0.9 1.5 1.8 -1.8 -2.0 1.2 -1.6 -2.1 -2.0 1.9 -1.8
Current tobacco smoking 0.6 1.0 3.0 -0.6 -1.3 -1.7 -0.8 1.1 0.9 -0.8 1.1 0.7 1.0 -0.5 1.1
Average weekly fortified wine intake 0.8 0.9 3.0 1.1 0.3 1.7 1.1 -0.2 -0.5 1.2 -0.2 -0.9 -0.7 1.3 -0.3
Maternal smoking around birth 0.3 0.4 3.5 -0.3 1.0 1.9 -0.3 0.0 -0.1 -0.4 -0.5 -0.1 -0.1 -0.3 -0.5
Fed-up feelings 2.4 4.4 6.8 -2.6 -1.1 0.8 -2.0 1.7 2.4 -2.5 1.9 2.5 2.3 -2.6 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 3.5 -1.1 0.1 0.3 -0.6 0.6 1.9 -1.0 1.8 1.3 1.4 -0.9 1.5
Relative age voice broke 0.1 0.1 0.7 0.1 0.8 -0.1 0.2 -0.4 0.0 -0.1 0.1 0.0 -0.1 -0.0 -0.1
Taking other prescription medications 1.6 2.5 8.2 1.2 1.4 2.9 1.4 -0.9 -1.6 1.2 -1.7 -1.4 -1.6 1.2 -1.6
Age when periods started (menarche) 1.1 2.7 5.7 2.2 1.4 -0.7 2.4 -2.0 -1.6 1.9 -0.9 -1.4 -1.6 2.0 -0.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 2.3 -0.1 1.5 1.3 -0.2 -1.0 0.6 0.2 0.7 0.2 0.4 0.1 0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 3.1 1.8 1.4 1.0 1.5 1.4 -1.5 1.6 -1.5 -1.3 -1.7 1.5 -1.4
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 4.2 1.2 2.0 0.9 1.0 -0.2 -1.0 1.3 -0.7 -1.2 -1.0 1.5 -0.8
Qualifications: CSEs or equivalent 1.4 1.9 2.7 1.3 1.5 0.8 1.6 0.3 -1.6 1.4 -1.2 -1.6 -1.5 1.6 -1.1
Serious illness, injury or assault to yourself 0.3 0.4 0.7 0.5 0.6 0.6 0.7 0.4 -0.4 0.7 -0.3 -0.8 -0.6 0.7 -0.6
High blood pressure 2.2 6.1 27.3 2.0 2.4 5.2 2.4 -1.1 -1.9 2.2 -1.2 -2.3 -2.2 2.4 -1.9
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.8 -0.2 0.9 1.4 -0.4 -1.1 -0.5 -0.3 -0.9 -0.3 -0.3 -0.3 -0.5
Multivitamins +/- minerals 0.4 0.5 2.0 0.5 0.5 -0.7 0.4 0.8 0.2 0.5 0.9 0.7 0.6 0.2 1.4
Stomach or abdominal pain in last month 0.2 0.3 0.7 -0.1 0.2 0.8 0.1 -0.6 -0.7 0.1 -0.9 -0.5 -0.6 0.1 -0.9
Supplements: Glucosamine 1.1 1.5 3.3 1.8 1.5 0.4 1.8 -0.9 -0.2 1.8 1.0 -0.4 -0.3 1.7 0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 -0.6 -0.6 -0.7 -0.6 0.5 -0.3 -0.6 -0.1 0.2 0.0 -0.4 -0.2
Medication: Atenolol 0.8 1.1 6.2 0.5 1.4 2.5 0.9 0.2 -0.6 0.7 -0.3 -0.9 -0.6 0.7 -0.7
Medication: Levothyroxine sodium 0.7 1.2 4.7 -1.4 -0.1 -0.3 -1.1 -0.4 -0.6 -1.3 -2.2 -0.3 -0.5 -1.1 -1.4
Sitting height 0.5 3.6 17.2 1.6 4.1 3.1 1.8 0.8 -0.9 1.9 -0.3 -1.4 -1.3 1.3 -0.8
Chronic bronchitis/emphysema (father) 1.2 1.4 3.3 1.2 1.4 1.8 1.0 0.8 -1.1 0.9 -0.8 -1.3 -1.2 0.7 -1.3
High blood pressure (mother) 0.8 1.1 3.3 -0.0 1.0 0.8 0.4 -1.6 -1.3 0.4 -1.8 -0.7 -1.3 0.6 -1.2
Body mass index (BMI) 1.3 5.4 18.4 2.4 3.1 4.3 2.8 -0.3 -1.4 2.6 -0.4 -2.0 -1.8 2.5 -1.1
Impedance of leg (left) 0.3 1.5 9.6 -0.9 -2.1 -3.1 -1.0 0.2 0.2 -0.9 0.1 0.3 0.3 -1.0 -0.3
Leg predicted mass (left) 1.0 5.1 17.9 2.0 4.1 4.2 2.5 -0.3 -1.1 2.2 -0.3 -1.8 -1.5 2.1 -0.8
Trunk fat mass 1.6 6.7 17.5 2.5 3.2 4.2 3.0 -0.5 -2.1 2.7 -1.1 -2.7 -2.5 2.6 -2.0
Waist circumference 1.1 4.1 17.0 1.8 2.7 4.1 2.3 -0.4 -1.1 2.0 -0.6 -1.8 -1.5 2.0 -1.1
Number of incorrect matches in round 0.1 0.2 0.5 0.7 0.1 0.2 0.5 0.5 0.4 0.6 0.7 0.3 0.3 0.2 0.6
Past tobacco smoking 0.2 0.3 1.1 -0.7 -1.1 -0.6 -0.6 0.0 -0.2 -0.7 -0.4 -0.2 0.2 -0.8 -0.2
Alcohol usually taken with meals 0.2 0.3 0.9 -0.1 0.3 -0.7 -0.4 0.6 0.3 -0.0 0.8 0.6 0.6 -0.1 0.9
Nervous feelings 0.2 0.3 1.2 0.3 0.3 -0.6 0.5 -0.5 0.3 0.3 0.9 0.7 0.5 0.1 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.9 -0.9 -0.6 0.5 -0.4 -0.6 0.9 -1.0 0.3 0.9 0.7 -0.7 0.7
Hearing difficulty/problems with background noise 0.3 0.5 1.4 -0.9 1.1 1.2 -0.8 -1.1 0.1 -0.8 -0.1 -0.0 0.2 -0.4 -0.3
Hair/balding pattern: Pattern 2 1.0 1.3 2.4 -1.6 -0.0 -0.7 -1.0 1.3 0.9 -1.4 0.6 1.4 1.0 -1.6 0.8
Had menopause 0.2 0.2 0.9 0.4 0.9 0.7 0.4 0.6 -0.0 0.5 0.2 -0.4 -0.3 0.6 -0.2
Had other major operations 1.1 1.4 3.2 -0.9 -0.1 0.0 -0.8 0.6 1.6 -0.8 1.8 1.5 1.4 -1.1 1.7
Forced vital capacity (FVC) 0.1 0.3 2.7 -0.3 1.6 0.2 -0.2 0.5 -0.2 -0.3 0.1 0.4 0.2 -0.7 0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 6.3 1.6 1.0 0.9 1.5 0.9 -2.1 1.4 -2.5 -1.8 -2.1 1.5 -2.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.8 -0.6 1.2 1.3 -0.5 0.2 1.2 -0.4 1.3 0.8 1.1 -0.3 1.3
Qualifications: None of the above 0.1 0.3 0.7 -0.5 0.8 0.6 -0.4 -0.4 0.5 -0.6 0.0 0.8 0.4 -0.7 0.4
Financial difficulties in last 2 years 0.6 0.7 2.3 1.0 0.2 1.4 1.2 1.5 -0.3 0.9 -0.1 -0.4 -0.5 1.0 -0.0
Mouth/teeth dental problems 1.6 2.5 4.2 1.8 0.8 -0.5 1.4 -1.3 -2.1 1.8 -1.4 -1.9 -1.8 1.8 -1.5
Heart attack 0.6 0.8 1.5 -0.9 0.2 -0.3 -0.7 0.6 1.0 -0.8 1.0 1.1 1.2 -0.7 1.2
Allergy 0.8 1.8 7.1 -0.3 -2.4 -2.7 -0.2 2.2 0.8 -0.3 0.9 0.7 0.6 -0.4 0.7
Pain all over the body in last month 0.7 0.7 1.7 -1.0 -0.4 -1.3 -1.2 -0.2 0.8 -0.9 0.4 1.0 0.7 -0.8 0.7
Diabetes (self-reported) 1.2 1.8 3.0 1.7 1.6 1.4 1.7 -1.6 -0.6 1.6 -0.1 -1.4 -1.0 1.6 -0.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.0 1.5 0.5 0.9 1.4 -1.7 -1.2 1.3 -1.1 -1.1 -1.1 1.4 -0.6
Medication: Ramipril 1.4 1.8 4.4 0.8 1.7 1.2 1.0 0.5 -1.3 1.0 -1.0 -1.8 -1.6 1.2 -2.1
Medication: Simvastatin 0.5 0.8 2.4 0.4 1.0 1.6 0.5 -1.2 -0.6 0.3 -0.9 -0.9 -0.8 0.5 -1.1
Fluid intelligence score 0.6 1.3 3.0 0.9 0.4 0.1 0.9 -1.7 -1.4 1.0 -1.5 -0.9 -1.4 0.8 -1.3
Illnesses of siblings 0.3 0.4 1.4 0.8 0.4 1.2 0.7 -0.4 0.0 0.6 0.5 -0.1 0.1 0.7 0.6
Neuroticism score 1.7 3.6 7.1 -1.6 -0.5 0.2 -1.2 1.9 2.4 -1.5 2.7 2.4 2.3 -1.7 2.4
Weight 1.7 8.4 23.7 2.8 4.6 4.9 3.4 -0.2 -1.9 3.1 -0.8 -2.7 -2.3 2.9 -1.6
Impedance of arm (right) 0.4 1.7 5.5 -0.6 -2.3 -2.3 -0.8 -1.1 -1.1 -0.8 -1.7 -0.4 -0.8 -0.6 -1.5
Arm fat percentage (right) 1.5 6.1 18.9 2.3 2.4 4.3 2.7 -0.9 -2.0 2.5 -1.2 -2.5 -2.4 2.5 -2.0
Trunk fat-free mass 0.9 5.3 19.8 1.9 4.5 4.2 2.5 -0.0 -0.8 2.2 -0.1 -1.7 -1.3 2.1 -0.6
Hip circumference 1.0 4.4 13.6 2.0 3.4 3.7 2.3 -0.2 -1.4 2.2 -0.5 -1.8 -1.7 2.0 -1.1
Time employed in main current job 1.1 1.3 2.8 1.2 1.2 -0.0 0.6 -1.3 -1.2 1.1 -1.0 -1.5 -1.4 0.8 -1.7
Alcohol intake versus 10 years previously 0.3 0.5 2.8 0.3 0.6 -0.4 0.5 1.7 -0.8 0.3 -1.1 -0.3 -0.7 0.2 -0.5
Father’s age at death 1.2 1.6 4.0 1.4 1.2 -0.2 0.9 -0.8 -1.3 1.4 -0.9 -2.0 -1.3 1.8 -1.3
Worrier / anxious feelings 0.3 0.5 1.2 -0.3 0.1 1.1 -0.1 1.0 0.5 -0.3 0.9 1.0 0.6 -0.6 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 2.3 0.4 0.9 1.5 0.7 0.1 0.3 0.6 0.4 -0.3 0.0 0.6 0.2
Falls in the last year 0.5 0.7 2.1 -0.2 -0.6 0.3 -0.5 1.2 1.2 -0.3 1.4 0.6 1.0 -0.2 1.0
Hair/balding pattern: Pattern 3 0.1 0.1 1.4 -0.1 -1.2 0.2 -0.3 -0.0 0.2 -0.0 -0.2 0.1 -0.0 0.2 0.0
Number of live births 0.3 0.4 0.9 0.9 -0.0 0.6 0.9 -0.9 -0.5 0.8 -0.5 -0.2 -0.4 0.5 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.2 0.4 1.5 0.4 0.5 0.4 -1.2 0.4 -1.0 -0.5 -0.9 0.1 -1.0
Pulse rate 1.1 1.9 6.2 -0.2 0.8 -1.4 -0.7 1.1 1.7 0.0 2.5 1.2 1.7 -0.2 2.2
Happiness 0.3 0.4 3.9 0.0 2.0 0.2 0.5 -0.7 0.1 0.2 0.1 -0.1 -0.0 0.3 0.2
Noisy workplace 1.1 1.4 3.5 -1.3 -0.5 -0.6 -1.2 1.9 1.3 -1.3 1.0 1.0 1.1 -1.6 0.5
Qualifications: A levels/AS levels or equivalent 0.2 0.5 4.3 -0.4 -2.1 -0.1 -0.6 0.0 0.2 -0.4 0.3 0.4 0.1 -0.6 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.4 -0.1 0.3 -0.6 -0.1 -0.6 -0.2 -0.1 0.3 0.1 -0.0 -0.4 -0.2
Mouth/teeth dental problems: Dentures 0.2 0.3 1.8 -0.5 0.8 1.4 -0.1 0.0 0.6 -0.4 0.0 0.5 0.2 -0.6 0.0
Asthma 1.0 2.0 8.5 0.8 2.9 2.6 0.9 -2.1 0.2 0.9 0.9 -0.0 0.1 0.8 0.7
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.8 5.1 0.7 0.8 0.9 0.8 -0.9 -1.6 0.8 -1.7 -1.8 -1.8 1.0 -2.2
Medication: Cholesterol lowering 0.4 0.7 3.6 -0.5 0.4 1.2 -0.3 -1.9 -0.5 -0.5 -1.1 -0.3 -0.4 -0.3 -1.0
Depression (self-reported) 0.2 0.3 1.0 -0.7 0.4 -1.0 -0.5 -0.5 0.3 -0.6 -0.3 0.4 0.3 -0.5 0.2
Medication: Lansoprazole 0.7 0.8 6.4 0.2 0.7 1.2 0.1 2.5 -0.0 0.1 -0.1 -0.4 -0.4 0.2 -0.7
Prospective memory result 0.3 0.4 1.9 0.3 0.7 0.2 0.4 1.4 0.5 0.4 1.0 0.2 0.3 0.2 0.5
Lung cancer (father) 0.2 0.3 1.4 -0.4 -0.3 1.2 -0.3 1.1 0.3 -0.4 -0.2 0.2 0.1 -0.3 0.1
Illnesses of mother 0.5 0.6 2.9 0.5 -1.0 -0.6 0.1 0.5 0.9 0.1 1.7 0.4 0.9 -0.2 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 1.6 -0.1 1.3 0.4 0.0 0.8 -1.0 -0.0 -1.0 -0.2 -0.5 -0.3 -0.7
Pulse wave Arterial Stiffness index 0.2 0.2 1.8 0.2 0.4 0.2 0.3 -1.3 -0.1 0.4 0.1 -0.1 0.1 0.6 0.4
Impedance of arm (left) 0.6 2.8 12.8 -1.2 -3.0 -3.6 -1.6 -0.2 -0.7 -1.5 -1.4 0.2 -0.2 -1.3 -1.0
Arm fat mass (right) 1.6 6.6 22.5 2.5 3.4 4.7 3.0 -0.7 -1.7 2.7 -0.7 -2.4 -2.1 2.6 -1.6
Trunk predicted mass 0.8 4.8 18.7 1.8 4.3 4.2 2.4 0.0 -0.7 2.1 -0.0 -1.6 -1.1 1.9 -0.5
Standing height 0.3 3.1 12.8 1.4 3.6 1.9 1.8 0.1 -1.4 1.6 -1.1 -1.9 -1.6 1.3 -1.5
Length of working week for main job 1.8 2.0 5.1 -1.2 -0.6 -0.3 -1.1 2.3 1.8 -1.3 1.4 1.5 1.5 -1.2 1.5
Exposure to tobacco smoke at home 0.8 0.9 3.2 0.1 0.4 -0.1 0.2 0.6 1.3 -0.1 1.8 1.2 1.1 -0.4 1.4
Breastfed as a baby 0.6 0.8 2.4 1.5 0.1 -0.0 1.1 -0.2 -0.3 1.4 0.5 -1.0 -0.7 1.5 -0.3
Tense / ‘highly strung’ 0.4 0.6 1.0 -0.9 -1.0 -0.7 -0.6 0.9 0.5 -1.0 0.1 1.0 0.6 -0.9 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 3.7 -1.6 -1.7 -0.9 -1.0 1.1 1.9 -1.5 1.8 1.7 1.8 -1.5 1.7
Hair/balding pattern: Pattern 4 0.3 0.6 1.5 1.2 1.0 -0.9 0.9 0.1 -0.7 1.2 -0.4 -0.6 -0.6 0.8 -0.4
Birth weight of first child 0.5 0.8 2.3 1.1 1.5 0.3 1.0 -1.2 -0.3 1.3 0.1 -0.6 -0.4 1.3 0.2
Peak expiratory flow (PEF) 0.9 2.1 5.5 0.9 1.3 0.2 0.8 -0.7 -2.1 0.9 -2.2 -1.3 -1.9 0.6 -2.4
Pulse wave reflection index 0.1 0.1 0.3 -0.3 -0.4 0.5 0.0 0.1 0.1 -0.2 -0.0 0.4 0.2 -0.2 0.4
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.7 -0.2 1.3 0.9 0.2 0.3 -0.2 0.0 -0.5 0.2 -0.2 -0.1 -0.1
Loud music exposure frequency 0.4 0.4 1.9 0.5 1.4 0.7 0.6 0.6 -0.4 0.6 -0.5 -0.5 -0.6 0.5 -0.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 4.4 -0.6 -2.1 -1.4 -0.7 1.2 0.3 -0.6 0.3 0.5 0.4 -0.7 0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.6 -0.8 -1.6 -0.7 -0.5 1.1 0.9 -0.8 0.6 0.5 0.5 -0.7 0.3
Blood clot in the leg (DVT) 1.7 2.2 7.5 1.7 1.4 0.4 1.9 -2.7 -1.2 1.8 -0.4 -1.1 -1.2 1.5 -0.8
Medication: Paracetamol 0.5 0.8 2.6 -1.0 -0.1 -0.6 -1.1 1.6 0.4 -1.1 -0.1 0.7 0.4 -1.3 -0.0
Headache pain in last month 0.1 0.2 1.8 -0.6 1.3 0.4 -0.5 0.1 0.2 -0.2 -0.1 -0.3 0.1 -0.1 -0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 4.1 0.4 -0.1 -2.0 0.3 0.7 0.0 0.5 0.5 0.1 0.1 0.4 0.6
Glaucoma (self-reported) 0.4 0.4 1.5 0.5 -0.9 0.4 0.5 -0.0 0.9 0.3 1.2 0.3 0.6 0.2 1.0
Gout (self-reported) 2.1 2.8 6.2 2.2 1.1 2.0 2.5 0.7 -1.5 2.0 -1.0 -1.2 -1.6 2.2 -0.8
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 4.2 -1.9 -1.5 -0.4 -1.6 -0.3 -0.4 -1.8 -2.0 0.3 -0.1 -1.6 -1.1
Medication: Amlodipine 0.8 1.1 6.2 0.9 0.9 2.5 1.0 -0.2 -0.7 0.7 -0.6 -1.0 -1.0 0.8 -1.0
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.8 0.4 1.7 1.3 0.6 -0.9 0.6 0.4 1.2 0.4 0.6 0.3 1.2
Birth weight 1.0 2.2 5.0 1.4 2.2 0.7 1.7 0.0 -1.6 1.6 -1.5 -1.5 -1.6 1.3 -1.6
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.1 0.8 1.0 0.9 0.8 -0.7 -0.4 0.8 -0.2 -0.7 -0.6 1.0 -0.3
High blood pressure (siblings) 0.3 0.4 0.8 0.4 -0.3 -0.3 0.5 0.8 -0.7 0.5 -0.9 -0.8 -0.9 0.6 -0.9
Forced vital capacity (FVC), Best measure 0.1 0.3 2.0 -0.4 1.4 0.3 -0.3 0.8 -0.2 -0.3 -0.2 0.4 0.2 -0.8 0.0
Body fat percentage 1.3 5.3 12.7 2.2 2.5 3.6 2.6 -0.5 -1.9 2.4 -1.1 -2.5 -2.3 2.4 -2.0
Leg fat percentage (right) 1.9 6.8 14.4 2.7 2.7 3.8 3.3 -0.5 -2.2 2.9 -1.2 -2.8 -2.6 2.8 -2.2
Arm fat-free mass (right) 1.0 5.0 19.5 2.0 4.4 4.0 2.5 0.2 -0.5 2.3 0.6 -1.6 -1.0 2.1 -0.2
Exposure to tobacco smoke outside home 0.9 1.2 2.7 1.4 0.3 0.8 1.6 -0.1 -1.3 1.5 -0.3 -1.3 -1.2 1.3 -0.8
Comparative body size at age 10 1.3 3.5 7.4 1.2 0.7 1.8 1.4 0.8 -2.3 1.2 -2.6 -2.4 -2.4 1.5 -2.7
Number of full brothers 0.4 0.5 3.9 0.7 -0.4 -2.0 0.4 0.2 -0.4 0.7 -0.1 0.3 -0.2 0.4 0.2
Worry too long after embarrassment 0.4 0.7 2.2 -0.4 -0.1 -0.2 0.1 1.0 1.2 -0.3 1.5 1.0 0.9 -0.5 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 2.7 -1.3 -0.7 0.0 -1.2 -0.9 1.6 -1.2 1.2 1.4 1.5 -1.2 1.4
Wheeze or whistling in the chest in last year 0.5 0.9 4.1 0.3 1.2 2.0 0.4 -0.8 0.7 0.5 1.4 -0.1 0.5 0.5 0.9
Number of children fathered 0.8 0.9 2.7 -1.3 -0.8 -0.6 -0.8 1.6 0.7 -1.2 0.2 1.0 0.7 -1.2 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 3.5 1.9 1.8 0.7 1.8 -1.6 -0.5 1.8 0.5 -0.8 -0.7 1.6 0.2
Age at first live birth 0.2 0.3 0.8 0.1 0.4 0.1 -0.0 -0.6 -0.6 0.1 -0.9 -0.7 -0.6 0.2 -0.9
Pulse wave peak to peak time 0.2 0.2 1.4 -0.1 -0.1 -0.0 -0.2 1.2 -0.1 -0.3 -0.3 -0.0 -0.3 -0.5 -0.6
Health satisfaction 0.2 0.3 1.7 -0.2 1.3 0.7 0.3 -0.1 -0.3 0.1 -0.7 -0.0 -0.2 0.3 0.2
Shortness of breath walking on level ground 0.4 0.5 2.7 -0.5 0.7 1.3 -0.3 -1.6 -0.0 -0.5 -0.7 0.4 -0.0 -0.1 0.0
Qualifications: College or University degree 0.0 0.1 0.9 -0.2 -0.2 -0.1 -0.3 -1.0 -0.1 -0.2 0.3 -0.1 0.1 -0.1 0.0
Eye problems/disorders: None of the above 0.8 0.9 3.3 0.7 1.8 0.6 0.6 -0.7 -1.1 0.8 -0.7 -0.8 -1.0 0.8 -1.1
Mouth/teeth dental problems: Loose teeth 1.5 1.8 2.9 -1.2 -0.2 -1.4 -1.3 1.6 1.7 -1.1 1.6 1.1 1.6 -0.9 1.7
Emphysema/chronic bronchitis 0.6 0.7 2.8 -0.9 -1.0 1.7 -0.8 -1.0 0.3 -1.0 -0.6 0.3 0.2 -0.8 -0.3
Medication for pain relief, constipation, heartburn 0.3 0.5 1.3 -0.2 -0.6 -1.2 -0.1 -0.0 0.8 -0.1 0.8 0.8 0.8 -0.3 1.2
Neck or shoulder pain in last month 0.1 0.1 0.4 -0.1 0.4 0.3 -0.4 0.2 0.4 -0.1 0.4 0.6 0.4 -0.3 0.3
Medication: Blood pressure 0.4 0.8 4.3 -0.9 0.2 2.1 -0.7 0.4 0.9 -0.9 0.9 0.3 0.7 -0.8 0.2
Angina (self-reported) 0.4 0.5 2.2 -0.2 0.5 1.5 -0.0 0.3 0.7 -0.1 0.9 0.7 0.7 -0.1 1.0
Migraine (self-reported) 1.2 1.5 4.3 -1.7 -0.8 -0.5 -1.3 2.1 1.1 -1.4 0.2 0.9 1.1 -1.4 0.7
Medication: Ibuprofen 0.3 0.3 1.2 0.2 -0.1 -0.1 0.2 0.0 -0.7 0.2 -0.7 -0.8 -0.8 0.3 -1.1
Medication: Allopurinol 1.8 2.4 5.5 2.1 0.5 1.9 2.3 -0.3 -1.4 1.9 -0.9 -1.4 -1.5 2.1 -0.7
Medication: Omeprazole 0.5 0.6 1.6 -0.9 -0.7 -0.1 -0.7 0.2 0.7 -0.9 0.4 1.3 0.9 -0.9 1.0
Medication: Seretide 50 evohaler 2.9 3.4 6.2 -1.5 -0.3 -1.0 -1.4 1.0 2.5 -1.4 2.5 2.2 2.4 -1.7 2.5
Mean time to correctly identify matches 1.4 2.7 9.2 0.9 3.0 2.9 0.7 -0.7 -0.9 1.1 -1.2 -1.7 -1.3 1.6 -1.5
Heart disease (mother) 0.4 0.5 1.1 -0.0 1.0 0.7 -0.0 -0.2 1.0 0.2 1.0 0.7 0.7 -0.1 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.8 3.4 5.3 2.3 0.9 2.3 2.2 -0.3 -1.6 2.3 -1.0 -2.0 -2.1 1.9 -1.7
Whole body fat mass 1.8 7.3 19.1 2.6 3.5 4.4 3.1 -0.6 -2.1 2.9 -1.1 -2.7 -2.5 2.7 -2.1
Leg fat mass (right) 2.0 7.7 19.7 2.8 3.7 4.4 3.4 -0.4 -2.0 3.0 -0.8 -2.8 -2.5 3.0 -1.9
Arm predicted mass (right) 0.9 4.7 19.8 1.9 4.4 4.0 2.3 0.2 -0.4 2.2 0.5 -1.4 -0.9 2.0 -0.1
Pulse rate, automated reading 0.4 1.4 4.9 1.5 2.2 0.2 1.0 1.8 0.0 1.5 0.8 -0.2 -0.2 1.3 0.6
Alcohol intake frequency. 0.5 1.1 4.8 0.3 -0.3 1.5 0.3 2.2 -0.7 0.2 -1.4 -0.9 -0.9 0.3 -1.1
Comparative height size at age 10 0.6 3.3 10.3 1.7 3.2 1.6 1.8 -0.5 -1.6 1.8 -1.5 -1.9 -1.8 1.6 -1.7
Number of full sisters 2.8 3.4 6.0 1.4 1.4 0.5 1.6 -2.5 -2.2 1.5 -2.4 -2.0 -2.1 1.8 -1.8
Suffer from ‘nerves’ 0.2 0.3 0.9 0.7 0.4 0.1 0.9 0.7 -0.6 0.6 -0.0 -0.3 -0.6 0.7 -0.3
Overall health rating 0.2 0.3 0.9 -0.7 0.9 0.9 -0.3 -0.7 -0.3 -0.4 -0.8 -0.2 -0.2 -0.4 -0.5
Chest pain or discomfort 0.3 0.4 2.8 -0.2 1.1 1.7 0.0 -0.2 0.1 0.1 0.2 0.4 0.2 -0.0 0.3
Had major operations 0.6 0.7 2.8 -0.0 0.1 0.3 -0.0 -0.5 1.1 -0.0 1.7 0.3 1.1 0.0 1.6
Age at last live birth 0.3 0.4 1.1 0.8 0.9 0.3 0.7 -1.0 -0.3 0.8 -0.0 -0.9 -0.5 0.8 -0.2
Family relationship satisfaction 0.4 0.5 2.2 -0.4 0.1 -0.6 -0.1 0.3 0.6 -0.4 0.5 1.2 1.0 -0.5 1.5
Leg pain on walking 0.3 0.4 1.1 -0.9 0.0 0.6 -0.7 -0.6 0.3 -0.9 -0.5 0.9 0.2 -1.0 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 3.8 -0.6 -0.6 -1.9 -0.4 2.0 0.1 -0.4 0.1 0.5 0.3 -0.5 0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.4 2.3 0.2 0.3 -1.5 0.4 0.2 -0.5 0.3 -1.0 -0.2 -0.6 0.2 -0.5
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 3.0 -1.3 -0.5 -0.2 -1.7 0.2 1.6 -1.4 1.4 1.4 1.7 -1.4 1.4
Medication: Aspirin 0.9 1.2 3.9 0.7 1.1 2.0 0.7 -1.4 -1.1 0.8 -0.8 -1.0 -1.0 1.0 -0.9
Supplements: Vitamin C 0.4 0.5 1.3 1.1 0.8 0.3 1.1 0.7 -0.1 1.0 0.4 0.2 0.0 0.7 0.8
Knee pain experienced in last month 0.2 0.3 1.2 0.4 0.2 1.1 0.8 -0.8 -0.2 0.4 0.0 -0.1 -0.2 0.6 0.2
Hypertension (Self-reported) 1.5 4.3 24.4 1.4 1.9 4.9 1.8 -1.0 -1.4 1.6 -0.8 -1.7 -1.7 1.9 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.5 -1.6 -0.1 0.3 -1.3 0.4 -0.2 -1.5 -1.3 0.4 -0.0 -1.3 -0.7
Illnesses of father: Heart disease 0.8 1.1 4.0 -0.7 -0.0 0.9 -0.6 -0.3 1.4 -0.5 2.0 1.0 1.3 -0.8 1.3
Illnesses of siblings: Diabetes 0.3 0.3 1.1 -0.6 -1.0 -0.8 -0.6 -0.5 0.6 -0.7 0.3 0.1 0.4 -0.6 0.1
Smoking status: Previous 0.3 0.4 1.5 0.6 1.2 1.2 0.6 -0.0 0.4 0.6 0.3 0.3 -0.1 0.6 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 5.2 2.1 1.5 1.8 2.2 -1.4 -2.1 2.2 -1.4 -2.3 -2.1 2.2 -1.8
Whole body fat-free mass 0.9 4.9 18.7 1.8 4.3 4.3 2.4 -0.1 -0.6 2.1 0.1 -1.6 -1.1 2.0 -0.4
Leg fat-free mass (right) 0.7 3.9 15.8 1.6 4.0 4.0 2.0 -0.2 -0.7 1.8 0.0 -1.3 -1.0 1.7 -0.3
Arm fat percentage (left) 1.1 4.4 13.5 2.0 2.1 3.7 2.3 -0.5 -1.8 2.1 -0.9 -2.2 -2.0 2.2 -1.7
Average weekly red wine intake 0.2 0.3 0.9 0.9 -0.5 0.4 0.8 -0.5 -0.3 0.9 0.4 -0.3 -0.2 0.8 0.3
Handedness (chirality/laterality): Left-handed 0.6 0.7 3.0 -0.9 -0.9 0.5 -0.8 -1.7 0.4 -0.8 0.2 0.6 0.6 -0.9 0.3
Mood swings 0.9 1.6 3.6 -1.9 -0.6 0.1 -1.4 0.8 1.3 -1.9 0.9 1.4 1.2 -1.9 0.7
Loneliness, isolation 2.9 4.0 6.4 -2.5 -1.6 -0.2 -2.1 1.2 2.4 -2.5 1.4 2.3 2.3 -2.4 1.8
Long-standing illness, disability or infirmity 1.5 2.3 6.2 1.0 2.4 2.5 1.1 -1.8 -1.2 1.2 -0.6 -1.4 -1.3 1.3 -1.4
Ever had bowel cancer screening 0.8 0.9 1.7 -0.6 -1.0 -0.5 -1.0 -0.2 1.2 -0.8 1.2 1.2 1.2 -0.7 1.3
Diabetes diagnosed by doctor 2.0 3.3 5.5 2.3 2.2 2.1 2.3 -1.7 -0.9 2.3 -0.3 -1.9 -1.5 2.1 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 -0.7 -0.6 -0.3 -0.6 -0.5 0.5 -0.8 -0.2 0.6 0.4 -0.5 0.4
Friendships satisfaction 1.1 1.3 4.3 -0.6 -0.3 0.2 -0.4 -0.7 1.7 -0.5 1.6 1.4 1.6 -0.4 2.1
Qualifications: nursing, teaching 0.4 0.7 1.7 1.1 -0.0 -0.8 0.9 0.5 0.2 1.2 1.3 -0.1 0.2 1.1 1.0
Commuting to job workplace: Walk 0.6 0.6 3.9 0.0 -0.4 2.0 -0.0 -1.7 0.2 -0.1 0.3 -0.0 0.3 0.2 0.4
Eye problems/disorders: Cataract 0.2 0.2 0.9 -0.4 -0.8 -0.3 -0.3 -0.2 -0.3 -0.5 -0.9 0.2 0.0 -0.4 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.6 -0.3 -0.5 0.4 -0.3 -0.8 0.3 -0.2 0.2 0.4 0.3 -0.3 0.3
Medication for cholesterol 2.8 4.2 6.9 -1.5 -2.0 -2.6 -1.9 1.5 2.3 -1.8 2.0 2.2 2.4 -1.8 2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.4 -1.4 -0.8 -1.9 -1.3 1.0 0.6 -1.4 0.4 1.0 0.9 -1.2 0.7
Back pain experienced in last month 1.0 1.5 5.7 1.0 2.4 1.7 1.0 1.5 -0.9 1.2 -0.7 -0.5 -0.9 0.9 -0.4
Mineral and other dietary supplements 0.5 0.7 2.0 -0.8 -0.3 -0.0 -0.9 -1.3 -0.6 -0.8 -1.2 -0.7 -0.5 -0.5 -1.4
Breast cancer (self-reported) 2.9 3.4 5.7 -2.1 -0.2 -1.4 -2.0 1.7 2.1 -2.0 1.2 2.4 2.1 -2.1 2.0
Asthma (self-reported) 1.0 2.0 9.1 1.0 3.0 2.2 1.1 -2.1 -0.0 1.1 0.8 -0.1 -0.1 1.0 0.6
Osteoporosis (self-reported) 1.3 1.7 3.5 -0.9 -0.6 -0.6 -0.9 0.6 1.7 -1.0 1.6 1.9 1.7 -0.9 1.9
Osteoarthritis (self-reported) 0.1 0.1 0.5 0.2 0.5 0.7 0.3 -0.0 -0.4 0.2 -0.1 0.1 -0.2 -0.0 -0.3
Medication: Aspirin 0.8 1.0 3.8 0.9 1.1 1.9 1.0 -1.5 -0.7 0.9 0.0 -0.6 -0.6 1.0 -0.2
Medication: Gliclazide 0.7 0.7 1.7 1.3 1.0 0.4 1.0 -0.5 0.5 1.2 1.1 -0.3 0.0 1.2 0.6
Illnesses of father: None of the above (group 1) 0.9 1.1 10.6 0.3 -1.4 -3.3 0.0 0.0 -0.2 0.0 -0.1 0.6 0.2 0.2 0.6
Smoking status: Current 0.4 0.7 2.6 -0.3 -1.3 -1.6 -0.5 0.9 0.6 -0.5 0.9 0.4 0.7 -0.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.7 -0.6 0.6 0.5 -0.6 1.4 0.9 -0.5 1.2 1.6 1.2 -1.0 1.4
Whole body water mass 0.9 5.2 19.8 1.9 4.4 4.4 2.4 -0.2 -0.7 2.2 0.1 -1.6 -1.2 2.0 -0.4
Leg predicted mass (right) 0.7 3.7 15.1 1.5 3.9 3.8 2.0 -0.2 -0.7 1.7 0.0 -1.3 -0.9 1.6 -0.3
Arm fat mass (left) 1.4 5.7 18.9 2.3 3.2 4.3 2.8 -0.5 -1.6 2.6 -0.5 -2.2 -1.9 2.5 -1.3
Number of self-reported non-cancer illnesses 2.2 3.9 14.2 1.8 2.4 3.8 2.1 -2.1 -1.4 1.8 -1.0 -1.3 -1.5 1.9 -1.0
Average weekly champagne plus white wine intake 2.5 3.4 6.4 -1.6 -1.8 0.1 -1.7 1.4 2.5 -1.8 2.5 1.8 2.1 -1.8 1.9
Miserableness 4.1 7.1 14.1 -2.5 -1.1 0.2 -2.4 1.3 3.5 -2.4 3.8 3.1 3.4 -2.5 3.2
Guilty feelings 0.1 0.2 1.9 0.1 0.0 0.2 0.5 -1.4 -0.0 0.1 0.4 0.3 0.0 0.2 0.3
Wears glasses or contact lenses 0.4 0.5 1.4 -1.1 0.1 -0.3 -1.0 0.7 0.3 -1.0 -0.0 0.1 0.2 -1.2 -0.5
Ever taken oral contraceptive pill 1.4 1.6 4.0 -0.9 0.5 -0.3 -0.6 -0.6 1.7 -0.8 1.8 2.0 1.5 -1.2 1.6
Hearing aid user 0.3 0.4 1.8 -0.2 0.2 1.3 -0.4 0.3 -0.3 -0.2 -0.8 -0.6 -0.5 -0.1 -1.0
Mother’s age at death 0.6 0.8 3.2 0.3 -0.0 -0.7 0.4 -0.5 -1.5 0.3 -1.8 -0.6 -1.1 0.7 -0.9
Financial situation satisfaction 1.0 1.2 4.3 -1.4 -1.1 -2.1 -1.0 0.4 0.9 -1.3 -0.2 1.1 0.9 -1.1 0.7
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.6 -1.4 -1.0 -1.9 -1.3 -0.0 1.2 -1.5 0.6 1.2 1.1 -1.1 0.9
Commuting to job workplace: Public transport 0.1 0.1 0.8 0.4 -0.9 0.2 0.3 -0.0 0.4 0.1 0.6 0.1 0.1 0.1 0.1
Eye problems/disorders: Glaucoma 0.3 0.3 1.0 0.7 -1.0 -0.2 0.9 -0.6 -0.0 0.5 0.3 -0.7 -0.3 0.5 -0.1
Medication: Blood pressure 1.1 2.0 10.4 0.9 1.2 3.2 1.0 -0.5 -1.1 1.1 -0.8 -1.3 -1.3 1.0 -1.6
Pain type(s) experienced in last month: Hip pain 0.9 1.2 3.6 -1.0 0.1 1.9 -0.7 1.5 1.1 -0.8 1.2 0.9 0.9 -1.0 0.9
Supplements: Fish oil (including cod liver oil) 0.3 0.5 1.3 0.7 0.2 0.5 0.9 1.2 0.1 0.7 0.7 0.6 0.2 0.3 1.0
High cholesterol (Self-reported) 0.3 0.6 1.3 1.0 0.1 0.9 1.0 -1.1 -0.4 0.9 0.0 -0.5 -0.5 0.9 -0.3
Medication: Bendroflumethiazide 2.3 3.4 8.0 1.5 1.6 2.8 1.8 -1.1 -1.9 1.5 -1.8 -2.1 -2.0 1.7 -2.0
Medication: Paracetamol 0.4 0.6 2.1 -0.9 0.3 -0.6 -1.0 1.5 0.5 -1.0 0.1 0.7 0.4 -1.1 -0.0
Medication: Lisinopril 0.3 0.4 1.3 0.2 0.3 0.8 0.3 -0.4 0.7 0.4 1.1 0.4 0.6 0.4 1.1
Medication: Atorvastatin 0.4 0.5 2.7 0.8 0.9 1.6 0.7 -0.6 -0.6 0.8 -0.0 0.2 -0.2 0.3 0.3
Illnesses of father: High blood pressure 0.4 0.5 2.8 -0.6 0.2 0.6 -0.5 1.7 0.7 -0.2 0.7 0.3 0.5 -0.1 0.6
Alcohol drinker status: Never 2.0 2.3 5.1 0.6 1.1 2.0 0.5 0.8 -1.8 0.6 -2.3 -2.0 -1.8 1.0 -2.2
Ever smoked 0.4 0.8 1.8 1.3 1.2 -0.0 1.2 0.0 -0.1 1.2 0.8 0.1 -0.2 1.4 0.6
Basal metabolic rate 1.1 5.9 20.7 2.1 4.5 4.5 2.7 -0.1 -1.0 2.4 -0.1 -1.8 -1.4 2.2 -0.7
Leg fat percentage (left) 1.4 5.2 12.1 2.3 2.6 3.5 2.8 -0.3 -1.9 2.5 -0.9 -2.4 -2.2 2.5 -1.8
Arm fat-free mass (left) 1.2 5.9 24.0 2.0 4.9 4.8 2.6 0.1 -0.6 2.3 0.3 -1.6 -1.1 2.0 -0.3
Number of operations (self-reported) 0.8 1.1 3.6 -0.3 0.7 1.3 -0.2 -0.4 1.7 -0.1 1.9 0.5 1.3 -0.2 1.7
Average weekly beer plus cider intake 0.7 1.1 3.0 1.7 0.5 -0.2 1.7 -1.0 -0.3 1.7 0.7 -0.4 -0.4 1.4 0.2
Irritability 0.4 0.8 1.9 -1.1 -0.0 1.4 -0.7 0.5 1.0 -0.9 0.9 0.9 0.9 -0.7 0.7
Risk taking 1.6 2.4 6.3 -0.3 0.2 -1.2 -0.3 2.1 1.9 -0.2 2.5 1.7 1.9 -0.5 2.5
Ever had prostate specific antigen (PSA) test 1.2 1.4 6.9 1.0 -0.8 2.6 0.9 -0.4 -1.1 0.9 -0.8 -1.2 -1.1 1.2 -0.9
Fractured/broken bones in last 5 years 0.4 0.6 1.5 0.4 1.0 0.7 0.4 -0.3 0.7 0.4 1.2 0.9 0.6 0.3 1.2
Age started oral contraceptive pill 0.5 0.7 3.3 0.8 1.8 1.0 0.8 -0.3 -0.3 0.8 0.1 -0.6 -0.5 1.0 -0.3
Diastolic blood pressure, automated reading 1.2 3.8 6.4 2.1 1.8 2.0 2.4 -0.2 -1.8 2.5 -1.3 -1.8 -2.2 2.5 -1.5
Ever depressed for a whole week 0.1 0.1 1.2 -0.1 1.1 0.4 -0.2 -0.2 -0.1 -0.1 -0.2 -0.2 -0.1 -0.0 -0.3
Unable to work because of sickness or disability 0.0 0.0 0.3 -0.2 -0.5 -0.1 0.1 -0.2 0.1 -0.1 -0.1 0.2 -0.0 0.0 0.2
Commuting to job workplace: Cycle 1.6 1.9 5.6 -0.7 -0.6 0.2 -1.1 0.4 1.6 -0.7 2.2 1.6 2.0 -0.9 2.4
Myopia 2.8 4.0 6.2 1.8 0.7 1.7 1.8 -2.5 -2.5 1.8 -2.4 -2.1 -2.3 2.0 -1.9
Vascular/heart problems diagnosed by doctor 1.9 5.1 23.7 -1.7 -2.5 -4.9 -2.2 1.1 1.6 -2.0 1.0 1.8 1.9 -2.2 1.4
Cholesterol lowering medication 0.8 1.1 2.4 1.4 1.5 1.3 1.3 -0.3 -0.9 1.4 -0.2 -0.7 -0.9 1.2 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.3 -0.7 -0.6 0.2 -0.6 0.7 0.6 -0.8 0.4 1.1 0.8 -0.8 0.8
Pain experienced in last month 0.4 0.7 3.0 -0.3 -1.7 -1.2 -0.4 -0.7 -0.6 -0.6 -1.1 -0.3 -0.5 -0.4 -0.8
Supplements: Calcium 0.3 0.4 1.2 0.1 -0.2 -0.6 -0.2 0.5 0.8 0.1 1.0 0.6 0.7 -0.0 1.1
Basal cell carcinoma (self-reported) 1.6 2.0 3.1 1.2 1.7 -0.4 1.0 0.5 -1.7 1.3 -1.7 -1.6 -1.7 1.3 -1.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.7 -0.8 0.3 -0.2 -0.6 0.6 1.1 -0.7 1.1 1.1 1.2 -0.6 1.3
Deep venous thrombosis (DVT) (self-reported) 1.7 2.1 7.2 1.7 1.3 0.3 1.9 -2.7 -1.2 1.8 -0.4 -1.1 -1.3 1.4 -0.9
Heart disease (siblings) 0.4 0.5 1.1 -0.8 -0.0 -0.8 -1.0 0.4 0.6 -0.7 0.2 0.9 0.7 -0.6 0.7
Alcohol drinker status: Previous 0.1 0.1 0.2 0.4 -0.1 0.2 0.5 -0.1 -0.1 0.4 0.0 0.0 -0.2 0.4 -0.1
Pack years of smoking 1.7 2.5 4.7 -2.2 -1.9 1.2 -1.8 1.2 1.6 -2.1 0.6 1.4 1.5 -1.9 0.8
Impedance of whole body 0.5 2.4 14.1 -1.1 -2.8 -3.8 -1.4 0.0 -0.2 -1.2 -0.7 0.2 0.0 -1.1 -0.7
Leg fat mass (left) 1.7 6.7 17.7 2.6 3.5 4.2 3.1 -0.2 -1.8 2.8 -0.7 -2.5 -2.2 2.7 -1.6
Arm predicted mass (left) 1.1 5.7 22.2 2.0 4.7 4.6 2.6 0.3 -0.5 2.3 0.5 -1.6 -1.0 2.1 -0.2