TWAS hub - TEAD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0970	0.0260	6.5e-08	0.080	0.054	0.047	0.055	0.071	5.3e-10	3.6e-07	2.2e-06	3e-07	5.9e-09
2	GTEx	Brain Caudate basal ganglia	0.3510	0.1040	3.7e-04	-0.007	NA	-0.008	NA	-0.007	5.5e-01	NA	6.4e-01	NA	5.8e-01
3	GTEx	Brain Hippocampus	0.2974	0.1225	6.2e-03	0.003	NA	0.014	NA	0.001	2.7e-01	NA	1.5e-01	NA	3.0e-01
4	GTEx	Brain Nucleus accumbens basal ganglia	0.3550	0.0940	5.2e-05	0.237	NA	0.172	NA	0.226	5.1e-07	NA	2.3e-05	NA	1.0e-06
5	GTEx	Cells Transformed fibroblasts	0.1500	0.0560	1.7e-03	-0.004	NA	0.031	NA	-0.001	8.2e-01	NA	2.2e-03	NA	4.3e-01
6	GTEx	Esophagus Mucosa	0.0700	0.0290	4.3e-03	0.050	NA	0.024	NA	0.036	3.0e-04	NA	8.9e-03	NA	1.8e-03
7	GTEx	Muscle Skeletal	0.1200	0.0336	1.1e-06	0.074	NA	0.027	NA	0.043	9.0e-08	NA	9.6e-04	NA	4.5e-05
8	YFS	Blood	0.0755	0.0146	0.0e+00	0.110	0.103	0.112	0.113	0.116	4.3e-34	8.6e-32	8.4e-35	6e-35	7.4e-36
9	TCGA	Bladder Urothelial Carcinoma	0.0310	0.0240	6.0e-03	0.007	0.014	0.010	NA	0.019	7.7e-02	2.1e-02	4.1e-02	NA	8.9e-03
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0293	0.0202	1.1e-03	0.011	0.022	0.015	NA	0.012	1.8e-02	1.5e-03	7.8e-03	NA	1.4e-02
11	TCGA	Brain Lower Grade Glioma	0.0331	0.0197	2.5e-04	0.031	0.034	0.036	NA	0.037	1.7e-04	9.4e-05	5.8e-05	NA	4.7e-05
12	TCGA	Thyroid Carcinoma	0.0340	0.0220	4.7e-04	0.046	0.026	0.030	NA	0.031	2.6e-05	1.3e-03	5.6e-04	NA	4.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Depressed Affect (Nagel 2018)	4.3	9.1	13.8	-3.6	-1.2	0.5	-3.2	2.4	3.7	-3.4	2.8	3.6	3.5	-3.6	2.9
Miserableness	4.1	7.1	14.1	-2.5	-1.1	0.2	-2.4	1.3	3.5	-2.4	3.8	3.1	3.4	-2.5	3.2
Medication: Metformin	4.0	5.6	8.5	2.7	2.7	1.7	2.6	-0.9	-2.2	2.6	-1.5	-2.9	-2.6	2.7	-2.3
Medication: Seretide 50 evohaler	2.9	3.4	6.2	-1.5	-0.3	-1.0	-1.4	1.0	2.5	-1.4	2.5	2.2	2.4	-1.7	2.5
Loneliness, isolation	2.9	4.0	6.4	-2.5	-1.6	-0.2	-2.1	1.2	2.4	-2.5	1.4	2.3	2.3	-2.4	1.8
Breast cancer (self-reported)	2.9	3.4	5.7	-2.1	-0.2	-1.4	-2.0	1.7	2.1	-2.0	1.2	2.4	2.1	-2.1	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.4	5.3	2.3	0.9	2.3	2.2	-0.3	-1.6	2.3	-1.0	-2.0	-2.1	1.9	-1.7
Number of full sisters	2.8	3.4	6.0	1.4	1.4	0.5	1.6	-2.5	-2.2	1.5	-2.4	-2.0	-2.1	1.8	-1.8
Medication for cholesterol	2.8	4.2	6.9	-1.5	-2.0	-2.6	-1.9	1.5	2.3	-1.8	2.0	2.2	2.4	-1.8	2.3
Myopia	2.8	4.0	6.2	1.8	0.7	1.7	1.8	-2.5	-2.5	1.8	-2.4	-2.1	-2.3	2.0	-1.9
Average weekly champagne plus white wine intake	2.5	3.4	6.4	-1.6	-1.8	0.1	-1.7	1.4	2.5	-1.8	2.5	1.8	2.1	-1.8	1.9
Fed-up feelings	2.4	4.4	6.8	-2.6	-1.1	0.8	-2.0	1.7	2.4	-2.5	1.9	2.5	2.3	-2.6	1.9
Medication: Bendroflumethiazide	2.3	3.4	8.0	1.5	1.6	2.8	1.8	-1.1	-1.9	1.5	-1.8	-2.1	-2.0	1.7	-2.0
High blood pressure	2.2	6.1	27.3	2.0	2.4	5.2	2.4	-1.1	-1.9	2.2	-1.2	-2.3	-2.2	2.4	-1.9
Number of self-reported non-cancer illnesses	2.2	3.9	14.2	1.8	2.4	3.8	2.1	-2.1	-1.4	1.8	-1.0	-1.3	-1.5	1.9	-1.0
Townsend deprivation index at recruitment	2.1	2.9	4.6	1.4	0.9	1.5	1.8	-1.8	-2.0	1.2	-1.6	-2.1	-2.0	1.9	-1.8
Gout (self-reported)	2.1	2.8	6.2	2.2	1.1	2.0	2.5	0.7	-1.5	2.0	-1.0	-1.2	-1.6	2.2	-0.8
Leg fat mass (right)	2.0	7.7	19.7	2.8	3.7	4.4	3.4	-0.4	-2.0	3.0	-0.8	-2.8	-2.5	3.0	-1.9
Diabetes diagnosed by doctor	2.0	3.3	5.5	2.3	2.2	2.1	2.3	-1.7	-0.9	2.3	-0.3	-1.9	-1.5	2.1	-1.0
Alcohol drinker status: Never	2.0	2.3	5.1	0.6	1.1	2.0	0.5	0.8	-1.8	0.6	-2.3	-2.0	-1.8	1.0	-2.2
Leg fat percentage (right)	1.9	6.8	14.4	2.7	2.7	3.8	3.3	-0.5	-2.2	2.9	-1.2	-2.8	-2.6	2.8	-2.2
Vascular/heart problems diagnosed by doctor	1.9	5.1	23.7	-1.7	-2.5	-4.9	-2.2	1.1	1.6	-2.0	1.0	1.8	1.9	-2.2	1.4
Alzheimer’s Disease (in mother)	1.8	2.1	4.0	-2.0	-1.2	-0.5	-1.8	0.9	1.6	-1.9	0.7	1.6	1.4	-1.9	0.9
Blood White Count	1.8	13.1	17.5	-3.9	-2.5	-4.0	-4.0	0.8	3.9	-3.7	3.2	4.2	4.1	-3.7	3.8
Hypothyroidism (self reported)	1.8	4.1	9.2	-3.0	-2.6	-1.4	-2.9	-0.4	0.5	-3.0	-1.7	1.2	0.8	-2.8	-0.5
Neuroticism	1.8	4.3	7.8	-1.9	0.0	0.7	-1.6	2.2	2.7	-1.7	2.8	2.5	2.5	-1.9	2.5
Length of working week for main job	1.8	2.0	5.1	-1.2	-0.6	-0.3	-1.1	2.3	1.8	-1.3	1.4	1.5	1.5	-1.2	1.5
Medication: Allopurinol	1.8	2.4	5.5	2.1	0.5	1.9	2.3	-0.3	-1.4	1.9	-0.9	-1.4	-1.5	2.1	-0.7
Whole body fat mass	1.8	7.3	19.1	2.6	3.5	4.4	3.1	-0.6	-2.1	2.9	-1.1	-2.7	-2.5	2.7	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	5.2	2.1	1.5	1.8	2.2	-1.4	-2.1	2.2	-1.4	-2.3	-2.1	2.2	-1.8
Neuroticism score	1.7	3.6	7.1	-1.6	-0.5	0.2	-1.2	1.9	2.4	-1.5	2.7	2.4	2.3	-1.7	2.4
Weight	1.7	8.4	23.7	2.8	4.6	4.9	3.4	-0.2	-1.9	3.1	-0.8	-2.7	-2.3	2.9	-1.6
Blood clot in the leg (DVT)	1.7	2.2	7.5	1.7	1.4	0.4	1.9	-2.7	-1.2	1.8	-0.4	-1.1	-1.2	1.5	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	7.2	1.7	1.3	0.3	1.9	-2.7	-1.2	1.8	-0.4	-1.1	-1.3	1.4	-0.9
Pack years of smoking	1.7	2.5	4.7	-2.2	-1.9	1.2	-1.8	1.2	1.6	-2.1	0.6	1.4	1.5	-1.9	0.8
Leg fat mass (left)	1.7	6.7	17.7	2.6	3.5	4.2	3.1	-0.2	-1.8	2.8	-0.7	-2.5	-2.2	2.7	-1.6
Taking other prescription medications	1.6	2.5	8.2	1.2	1.4	2.9	1.4	-0.9	-1.6	1.2	-1.7	-1.4	-1.6	1.2	-1.6
Trunk fat mass	1.6	6.7	17.5	2.5	3.2	4.2	3.0	-0.5	-2.1	2.7	-1.1	-2.7	-2.5	2.6	-2.0
Mouth/teeth dental problems	1.6	2.5	4.2	1.8	0.8	-0.5	1.4	-1.3	-2.1	1.8	-1.4	-1.9	-1.8	1.8	-1.5
Arm fat mass (right)	1.6	6.6	22.5	2.5	3.4	4.7	3.0	-0.7	-1.7	2.7	-0.7	-2.4	-2.1	2.6	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	3.7	-1.6	-1.7	-0.9	-1.0	1.1	1.9	-1.5	1.8	1.7	1.8	-1.5	1.7
Risk taking	1.6	2.4	6.3	-0.3	0.2	-1.2	-0.3	2.1	1.9	-0.2	2.5	1.7	1.9	-0.5	2.5
Commuting to job workplace: Cycle	1.6	1.9	5.6	-0.7	-0.6	0.2	-1.1	0.4	1.6	-0.7	2.2	1.6	2.0	-0.9	2.4
Basal cell carcinoma (self-reported)	1.6	2.0	3.1	1.2	1.7	-0.4	1.0	0.5	-1.7	1.3	-1.7	-1.6	-1.7	1.3	-1.8
Fasting Glucose	1.5	1.8	2.9	-1.7	-1.7	-0.8	-1.0	0.3	1.7	-1.5	1.1	1.6	1.4	-1.0	1.3
Lupus	1.5	2.2	5.8	1.9	2.0	1.8	2.4	-1.1	0.1	1.9	0.9	-0.5	-0.3	1.8	0.8
Arm fat percentage (right)	1.5	6.1	18.9	2.3	2.4	4.3	2.7	-0.9	-2.0	2.5	-1.2	-2.5	-2.4	2.5	-2.0
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.8	5.1	0.7	0.8	0.9	0.8	-0.9	-1.6	0.8	-1.7	-1.8	-1.8	1.0	-2.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.9	-1.2	-0.2	-1.4	-1.3	1.6	1.7	-1.1	1.6	1.1	1.6	-0.9	1.7
Hypertension (Self-reported)	1.5	4.3	24.4	1.4	1.9	4.9	1.8	-1.0	-1.4	1.6	-0.8	-1.7	-1.7	1.9	-1.5
Long-standing illness, disability or infirmity	1.5	2.3	6.2	1.0	2.4	2.5	1.1	-1.8	-1.2	1.2	-0.6	-1.4	-1.3	1.3	-1.4
Body Mass Index (BMI) (2010)	1.4	1.9	4.1	1.8	1.0	1.2	1.8	-0.8	-0.9	2.0	0.0	-1.5	-1.1	2.0	-0.5
Number of treatments/medications taken	1.4	2.5	8.4	0.7	1.4	2.9	1.2	-1.1	-1.7	0.8	-1.8	-1.5	-1.7	1.0	-1.9
Qualifications: CSEs or equivalent	1.4	1.9	2.7	1.3	1.5	0.8	1.6	0.3	-1.6	1.4	-1.2	-1.6	-1.5	1.6	-1.1
Medication: Ramipril	1.4	1.8	4.4	0.8	1.7	1.2	1.0	0.5	-1.3	1.0	-1.0	-1.8	-1.6	1.2	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.5	1.9	1.8	0.7	1.8	-1.6	-0.5	1.8	0.5	-0.8	-0.7	1.6	0.2
Mean time to correctly identify matches	1.4	2.7	9.2	0.9	3.0	2.9	0.7	-0.7	-0.9	1.1	-1.2	-1.7	-1.3	1.6	-1.5
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.0	-1.3	-0.5	-0.2	-1.7	0.2	1.6	-1.4	1.4	1.4	1.7	-1.4	1.4
Arm fat mass (left)	1.4	5.7	18.9	2.3	3.2	4.3	2.8	-0.5	-1.6	2.6	-0.5	-2.2	-1.9	2.5	-1.3
Ever taken oral contraceptive pill	1.4	1.6	4.0	-0.9	0.5	-0.3	-0.6	-0.6	1.7	-0.8	1.8	2.0	1.5	-1.2	1.6
Leg fat percentage (left)	1.4	5.2	12.1	2.3	2.6	3.5	2.8	-0.3	-1.9	2.5	-0.9	-2.4	-2.2	2.5	-1.8
Type 2 Diabetes (T2D) (2012)	1.3	1.5	5.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.9	-2.2	2.4	-1.9
Body mass index (BMI)	1.3	5.4	18.4	2.4	3.1	4.3	2.8	-0.3	-1.4	2.6	-0.4	-2.0	-1.8	2.5	-1.1
Body fat percentage	1.3	5.3	12.7	2.2	2.5	3.6	2.6	-0.5	-1.9	2.4	-1.1	-2.5	-2.3	2.4	-2.0
Comparative body size at age 10	1.3	3.5	7.4	1.2	0.7	1.8	1.4	0.8	-2.3	1.2	-2.6	-2.4	-2.4	1.5	-2.7
Osteoporosis (self-reported)	1.3	1.7	3.5	-0.9	-0.6	-0.6	-0.9	0.6	1.7	-1.0	1.6	1.9	1.7	-0.9	1.9
Neuroticism (Nagel 2018)	1.2	2.8	6.6	-1.1	0.3	0.8	-1.1	2.1	2.0	-1.0	2.6	1.8	2.0	-1.6	2.1
Pack years adult smoking proportion	1.2	1.8	3.1	-1.8	-1.6	1.1	-1.5	1.1	1.3	-1.7	0.6	1.1	1.3	-1.6	0.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.2	1.2	2.0	0.9	1.0	-0.2	-1.0	1.3	-0.7	-1.2	-1.0	1.5	-0.8
Chronic bronchitis/emphysema (father)	1.2	1.4	3.3	1.2	1.4	1.8	1.0	0.8	-1.1	0.9	-0.8	-1.3	-1.2	0.7	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.3	1.6	1.0	0.9	1.5	0.9	-2.1	1.4	-2.5	-1.8	-2.1	1.5	-2.0
Diabetes (self-reported)	1.2	1.8	3.0	1.7	1.6	1.4	1.7	-1.6	-0.6	1.6	-0.1	-1.4	-1.0	1.6	-0.6
Father’s age at death	1.2	1.6	4.0	1.4	1.2	-0.2	0.9	-0.8	-1.3	1.4	-0.9	-2.0	-1.3	1.8	-1.3
Migraine (self-reported)	1.2	1.5	4.3	-1.7	-0.8	-0.5	-1.3	2.1	1.1	-1.4	0.2	0.9	1.1	-1.4	0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.6	-1.4	-1.0	-1.9	-1.3	-0.0	1.2	-1.5	0.6	1.2	1.1	-1.1	0.9
Arm fat-free mass (left)	1.2	5.9	24.0	2.0	4.9	4.8	2.6	0.1	-0.6	2.3	0.3	-1.6	-1.1	2.0	-0.3
Ever had prostate specific antigen (PSA) test	1.2	1.4	6.9	1.0	-0.8	2.6	0.9	-0.4	-1.1	0.9	-0.8	-1.2	-1.1	1.2	-0.9
Diastolic blood pressure, automated reading	1.2	3.8	6.4	2.1	1.8	2.0	2.4	-0.2	-1.8	2.5	-1.3	-1.8	-2.2	2.5	-1.5
Depression (Nagel 2018)	1.1	1.6	4.0	-0.6	0.5	0.9	-0.2	0.8	2.0	-0.4	2.0	1.4	1.6	-0.7	2.0
Cardiovascular Disease	1.1	3.6	22.0	1.3	1.6	4.7	1.7	-1.9	-1.0	1.5	-0.6	-1.3	-1.4	1.7	-0.9
Systolic blood pressure, automated reading	1.1	3.3	5.8	1.4	0.9	1.7	1.7	-0.6	-2.3	1.7	-2.0	-2.0	-2.4	2.0	-2.3
Supplements: Zinc	1.1	1.2	3.4	1.8	1.4	-0.0	1.8	-0.2	-0.6	1.8	-0.0	-0.5	-0.7	1.4	0.0
Trunk fat percentage	1.1	4.6	10.8	2.1	2.3	3.3	2.4	-0.6	-1.9	2.2	-1.1	-2.3	-2.2	2.1	-1.9
Age when periods started (menarche)	1.1	2.7	5.7	2.2	1.4	-0.7	2.4	-2.0	-1.6	1.9	-0.9	-1.4	-1.6	2.0	-0.8
Supplements: Glucosamine	1.1	1.5	3.3	1.8	1.5	0.4	1.8	-0.9	-0.2	1.8	1.0	-0.4	-0.3	1.7	0.6
Waist circumference	1.1	4.1	17.0	1.8	2.7	4.1	2.3	-0.4	-1.1	2.0	-0.6	-1.8	-1.5	2.0	-1.1
Had other major operations	1.1	1.4	3.2	-0.9	-0.1	0.0	-0.8	0.6	1.6	-0.8	1.8	1.5	1.4	-1.1	1.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.0	1.5	0.5	0.9	1.4	-1.7	-1.2	1.3	-1.1	-1.1	-1.1	1.4	-0.6
Time employed in main current job	1.1	1.3	2.8	1.2	1.2	-0.0	0.6	-1.3	-1.2	1.1	-1.0	-1.5	-1.4	0.8	-1.7
Pulse rate	1.1	1.9	6.2	-0.2	0.8	-1.4	-0.7	1.1	1.7	0.0	2.5	1.2	1.7	-0.2	2.2
Noisy workplace	1.1	1.4	3.5	-1.3	-0.5	-0.6	-1.2	1.9	1.3	-1.3	1.0	1.0	1.1	-1.6	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.7	-1.3	-0.7	0.0	-1.2	-0.9	1.6	-1.2	1.2	1.4	1.5	-1.2	1.4
Arm fat percentage (left)	1.1	4.4	13.5	2.0	2.1	3.7	2.3	-0.5	-1.8	2.1	-0.9	-2.2	-2.0	2.2	-1.7
Friendships satisfaction	1.1	1.3	4.3	-0.6	-0.3	0.2	-0.4	-0.7	1.7	-0.5	1.6	1.4	1.6	-0.4	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.4	-1.4	-0.8	-1.9	-1.3	1.0	0.6	-1.4	0.4	1.0	0.9	-1.2	0.7
Medication: Blood pressure	1.1	2.0	10.4	0.9	1.2	3.2	1.0	-0.5	-1.1	1.1	-0.8	-1.3	-1.3	1.0	-1.6
Basal metabolic rate	1.1	5.9	20.7	2.1	4.5	4.5	2.7	-0.1	-1.0	2.4	-0.1	-1.8	-1.4	2.2	-0.7
Arm predicted mass (left)	1.1	5.7	22.2	2.0	4.7	4.6	2.6	0.3	-0.5	2.3	0.5	-1.6	-1.0	2.1	-0.2
Alzheimer’s Disease (including proxy)	1.0	1.5	2.5	-1.3	-0.4	0.6	-1.2	1.1	1.6	-1.2	1.4	1.3	1.4	-1.4	1.2
Reaction Time	1.0	1.8	8.1	0.6	2.8	2.7	0.4	-0.2	-0.5	0.7	-0.7	-1.4	-0.9	1.0	-1.1
Rheumatoid Arthritis	1.0	1.4	4.7	1.1	1.6	1.1	1.2	-2.2	-0.9	1.1	-1.0	-0.3	-0.7	1.1	-0.2
Blood Eosinophil Count	1.0	7.9	22.1	3.6	4.7	0.4	3.4	-3.7	-0.5	3.8	1.9	-1.2	-0.9	3.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.5	-1.1	0.1	0.3	-0.6	0.6	1.9	-1.0	1.8	1.3	1.4	-0.9	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.1	1.8	1.4	1.0	1.5	1.4	-1.5	1.6	-1.5	-1.3	-1.7	1.5	-1.4
Leg predicted mass (left)	1.0	5.1	17.9	2.0	4.1	4.2	2.5	-0.3	-1.1	2.2	-0.3	-1.8	-1.5	2.1	-0.8
Hair/balding pattern: Pattern 2	1.0	1.3	2.4	-1.6	-0.0	-0.7	-1.0	1.3	0.9	-1.4	0.6	1.4	1.0	-1.6	0.8
Hip circumference	1.0	4.4	13.6	2.0	3.4	3.7	2.3	-0.2	-1.4	2.2	-0.5	-1.8	-1.7	2.0	-1.1
Asthma	1.0	2.0	8.5	0.8	2.9	2.6	0.9	-2.1	0.2	0.9	0.9	-0.0	0.1	0.8	0.7
Birth weight	1.0	2.2	5.0	1.4	2.2	0.7	1.7	0.0	-1.6	1.6	-1.5	-1.5	-1.6	1.3	-1.6
Arm fat-free mass (right)	1.0	5.0	19.5	2.0	4.4	4.0	2.5	0.2	-0.5	2.3	0.6	-1.6	-1.0	2.1	-0.2
Back pain experienced in last month	1.0	1.5	5.7	1.0	2.4	1.7	1.0	1.5	-0.9	1.2	-0.7	-0.5	-0.9	0.9	-0.4
Asthma (self-reported)	1.0	2.0	9.1	1.0	3.0	2.2	1.1	-2.1	-0.0	1.1	0.8	-0.1	-0.1	1.0	0.6
Financial situation satisfaction	1.0	1.2	4.3	-1.4	-1.1	-2.1	-1.0	0.4	0.9	-1.3	-0.2	1.1	0.9	-1.1	0.7
Breast Cancer	0.9	2.2	7.5	1.8	0.7	2.7	1.8	-1.6	-0.8	1.6	-0.1	-1.5	-0.9	1.7	-0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.8	3.0	1.7	1.7	0.7	1.7	-0.8	-1.0	1.6	-0.8	-1.4	-1.3	1.6	-0.8
Sensitivity / hurt feelings	0.9	1.5	4.8	-0.5	1.5	-0.0	-0.4	2.2	1.3	-0.4	1.8	1.2	1.2	-0.6	1.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.3	-1.0	0.1	-0.9	-0.7	0.5	1.5	-0.8	1.5	1.4	1.4	-0.9	1.5
Ever had hysterectomy (womb removed)	0.9	1.0	1.7	-1.3	-0.7	0.2	-1.3	0.6	1.3	-1.0	1.0	0.9	1.2	-0.9	1.1
Medication: Co-codamol	0.9	1.0	2.7	-1.0	0.2	0.2	-0.8	0.4	1.4	-0.7	1.6	1.1	1.2	-0.8	1.3
Leg fat-free mass (left)	0.9	5.0	17.6	2.0	4.1	4.2	2.5	-0.3	-1.0	2.2	-0.2	-1.8	-1.4	2.1	-0.7
Trunk fat-free mass	0.9	5.3	19.8	1.9	4.5	4.2	2.5	-0.0	-0.8	2.2	-0.1	-1.7	-1.3	2.1	-0.6
Peak expiratory flow (PEF)	0.9	2.1	5.5	0.9	1.3	0.2	0.8	-0.7	-2.1	0.9	-2.2	-1.3	-1.9	0.6	-2.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.2	-1.9	-1.5	-0.4	-1.6	-0.3	-0.4	-1.8	-2.0	0.3	-0.1	-1.6	-1.1
Exposure to tobacco smoke outside home	0.9	1.2	2.7	1.4	0.3	0.8	1.6	-0.1	-1.3	1.5	-0.3	-1.3	-1.2	1.3	-0.8
Arm predicted mass (right)	0.9	4.7	19.8	1.9	4.4	4.0	2.3	0.2	-0.4	2.2	0.5	-1.4	-0.9	2.0	-0.1
Medication: Aspirin	0.9	1.2	3.9	0.7	1.1	2.0	0.7	-1.4	-1.1	0.8	-0.8	-1.0	-1.0	1.0	-0.9
Whole body fat-free mass	0.9	4.9	18.7	1.8	4.3	4.3	2.4	-0.1	-0.6	2.1	0.1	-1.6	-1.1	2.0	-0.4
Mood swings	0.9	1.6	3.6	-1.9	-0.6	0.1	-1.4	0.8	1.3	-1.9	0.9	1.4	1.2	-1.9	0.7
Illnesses of father: None of the above (group 1)	0.9	1.1	10.6	0.3	-1.4	-3.3	0.0	0.0	-0.2	0.0	-0.1	0.6	0.2	0.2	0.6
Whole body water mass	0.9	5.2	19.8	1.9	4.4	4.4	2.4	-0.2	-0.7	2.2	0.1	-1.6	-1.2	2.0	-0.4
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.6	-1.0	0.1	1.9	-0.7	1.5	1.1	-0.8	1.2	0.9	0.9	-1.0	0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.8	0.2	0.5	1.1	0.3	-0.5	1.3	0.1	1.5	0.7	1.0	0.1	1.7
Diabetes (father)	0.8	1.0	2.4	-1.0	-0.7	-1.6	-0.8	0.3	1.0	-0.8	1.0	1.1	1.1	-0.8	1.2
Average weekly fortified wine intake	0.8	0.9	3.0	1.1	0.3	1.7	1.1	-0.2	-0.5	1.2	-0.2	-0.9	-0.7	1.3	-0.3
Medication: Atenolol	0.8	1.1	6.2	0.5	1.4	2.5	0.9	0.2	-0.6	0.7	-0.3	-0.9	-0.6	0.7	-0.7
High blood pressure (mother)	0.8	1.1	3.3	-0.0	1.0	0.8	0.4	-1.6	-1.3	0.4	-1.8	-0.7	-1.3	0.6	-1.2
Allergy	0.8	1.8	7.1	-0.3	-2.4	-2.7	-0.2	2.2	0.8	-0.3	0.9	0.7	0.6	-0.4	0.7
Trunk predicted mass	0.8	4.8	18.7	1.8	4.3	4.2	2.4	0.0	-0.7	2.1	-0.0	-1.6	-1.1	1.9	-0.5
Exposure to tobacco smoke at home	0.8	0.9	3.2	0.1	0.4	-0.1	0.2	0.6	1.3	-0.1	1.8	1.2	1.1	-0.4	1.4
Medication: Amlodipine	0.8	1.1	6.2	0.9	0.9	2.5	1.0	-0.2	-0.7	0.7	-0.6	-1.0	-1.0	0.8	-1.0
Number of children fathered	0.8	0.9	2.7	-1.3	-0.8	-0.6	-0.8	1.6	0.7	-1.2	0.2	1.0	0.7	-1.2	0.3
Eye problems/disorders: None of the above	0.8	0.9	3.3	0.7	1.8	0.6	0.6	-0.7	-1.1	0.8	-0.7	-0.8	-1.0	0.8	-1.1
Illnesses of father: Heart disease	0.8	1.1	4.0	-0.7	-0.0	0.9	-0.6	-0.3	1.4	-0.5	2.0	1.0	1.3	-0.8	1.3
Ever had bowel cancer screening	0.8	0.9	1.7	-0.6	-1.0	-0.5	-1.0	-0.2	1.2	-0.8	1.2	1.2	1.2	-0.7	1.3
Medication: Aspirin	0.8	1.0	3.8	0.9	1.1	1.9	1.0	-1.5	-0.7	0.9	0.0	-0.6	-0.6	1.0	-0.2
Number of operations (self-reported)	0.8	1.1	3.6	-0.3	0.7	1.3	-0.2	-0.4	1.7	-0.1	1.9	0.5	1.3	-0.2	1.7
Cholesterol lowering medication	0.8	1.1	2.4	1.4	1.5	1.3	1.3	-0.3	-0.9	1.4	-0.2	-0.7	-0.9	1.2	-0.5
Primary Biliary Cirrhosis	0.7	1.0	2.6	1.6	0.4	1.1	1.4	-0.2	-0.2	1.4	0.4	-1.1	-0.6	1.4	-0.0
BMI	0.7	3.9	18.2	1.7	2.8	4.3	2.2	-0.3	-1.0	1.8	-0.4	-1.6	-1.4	1.9	-0.9
Lung FEV1/FVC ratio	0.7	3.4	5.8	1.8	-0.2	1.4	2.0	-0.2	-2.3	1.6	-2.1	-2.1	-2.4	1.9	-2.4
Lung FVC	0.7	3.3	4.6	-1.8	0.9	-0.5	-1.9	2.0	1.8	-1.7	1.9	2.1	2.1	-2.1	2.0
Average weekly spirits intake	0.7	0.9	1.7	-1.0	-0.3	0.7	-1.0	0.5	1.3	-1.1	0.5	1.1	1.0	-1.3	0.7
Vitamin and mineral supplements	0.7	1.0	3.7	-0.4	-0.4	0.4	-0.3	-1.6	-0.6	-0.3	-1.4	-1.1	-1.0	-0.1	-1.9
Medication: Levothyroxine sodium	0.7	1.2	4.7	-1.4	-0.1	-0.3	-1.1	-0.4	-0.6	-1.3	-2.2	-0.3	-0.5	-1.1	-1.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.8	-0.6	1.2	1.3	-0.5	0.2	1.2	-0.4	1.3	0.8	1.1	-0.3	1.3
Pain all over the body in last month	0.7	0.7	1.7	-1.0	-0.4	-1.3	-1.2	-0.2	0.8	-0.9	0.4	1.0	0.7	-0.8	0.7
Medication: Lansoprazole	0.7	0.8	6.4	0.2	0.7	1.2	0.1	2.5	-0.0	0.1	-0.1	-0.4	-0.4	0.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.5	-1.6	-0.1	0.3	-1.3	0.4	-0.2	-1.5	-1.3	0.4	-0.0	-1.3	-0.7
Leg fat-free mass (right)	0.7	3.9	15.8	1.6	4.0	4.0	2.0	-0.2	-0.7	1.8	0.0	-1.3	-1.0	1.7	-0.3
Medication: Gliclazide	0.7	0.7	1.7	1.3	1.0	0.4	1.0	-0.5	0.5	1.2	1.1	-0.3	0.0	1.2	0.6
Leg predicted mass (right)	0.7	3.7	15.1	1.5	3.9	3.8	2.0	-0.2	-0.7	1.7	0.0	-1.3	-0.9	1.6	-0.3
Average weekly beer plus cider intake	0.7	1.1	3.0	1.7	0.5	-0.2	1.7	-1.0	-0.3	1.7	0.7	-0.4	-0.4	1.4	0.2
Heel T-Score	0.6	5.1	14.7	1.2	0.9	0.5	1.0	1.2	-3.3	1.2	-3.8	-2.6	-2.9	1.4	-3.3
Smoking Status	0.6	1.5	3.7	-0.3	-1.2	-0.5	-0.4	1.6	1.6	-0.5	1.9	1.4	1.3	-0.4	1.7
Medication for hormone replacement therapy	0.6	0.7	2.1	0.0	0.2	-0.4	0.2	-0.7	-1.1	0.2	-1.5	-1.0	-1.0	0.5	-1.2
Current tobacco smoking	0.6	1.0	3.0	-0.6	-1.3	-1.7	-0.8	1.1	0.9	-0.8	1.1	0.7	1.0	-0.5	1.1
Financial difficulties in last 2 years	0.6	0.7	2.3	1.0	0.2	1.4	1.2	1.5	-0.3	0.9	-0.1	-0.4	-0.5	1.0	-0.0
Heart attack	0.6	0.8	1.5	-0.9	0.2	-0.3	-0.7	0.6	1.0	-0.8	1.0	1.1	1.2	-0.7	1.2
Fluid intelligence score	0.6	1.3	3.0	0.9	0.4	0.1	0.9	-1.7	-1.4	1.0	-1.5	-0.9	-1.4	0.8	-1.3
Impedance of arm (left)	0.6	2.8	12.8	-1.2	-3.0	-3.6	-1.6	-0.2	-0.7	-1.5	-1.4	0.2	-0.2	-1.3	-1.0
Breastfed as a baby	0.6	0.8	2.4	1.5	0.1	-0.0	1.1	-0.2	-0.3	1.4	0.5	-1.0	-0.7	1.5	-0.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.8	0.4	1.7	1.3	0.6	-0.9	0.6	0.4	1.2	0.4	0.6	0.3	1.2
Emphysema/chronic bronchitis	0.6	0.7	2.8	-0.9	-1.0	1.7	-0.8	-1.0	0.3	-1.0	-0.6	0.3	0.2	-0.8	-0.3
Comparative height size at age 10	0.6	3.3	10.3	1.7	3.2	1.6	1.8	-0.5	-1.6	1.8	-1.5	-1.9	-1.8	1.6	-1.7
Had major operations	0.6	0.7	2.8	-0.0	0.1	0.3	-0.0	-0.5	1.1	-0.0	1.7	0.3	1.1	0.0	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.8	-0.6	-0.6	-1.9	-0.4	2.0	0.1	-0.4	0.1	0.5	0.3	-0.5	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.0	-0.9	-0.9	0.5	-0.8	-1.7	0.4	-0.8	0.2	0.6	0.6	-0.9	0.3
Commuting to job workplace: Walk	0.6	0.6	3.9	0.0	-0.4	2.0	-0.0	-1.7	0.2	-0.1	0.3	-0.0	0.3	0.2	0.4
Mother’s age at death	0.6	0.8	3.2	0.3	-0.0	-0.7	0.4	-0.5	-1.5	0.3	-1.8	-0.6	-1.1	0.7	-0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	-0.8	0.3	-0.2	-0.6	0.6	1.1	-0.7	1.1	1.1	1.2	-0.6	1.3
Age at First Birth	0.5	0.7	3.6	0.7	1.9	0.8	0.7	-0.3	-0.6	0.7	-0.3	-0.8	-0.5	0.8	-0.5
Respiratory disease	0.5	1.1	4.2	0.7	2.1	1.7	0.9	-1.8	-0.1	0.8	0.5	-0.1	0.0	0.7	0.6
Chronotype (morning person)	0.5	1.2	3.2	0.3	1.8	1.6	0.5	1.6	0.9	0.4	1.4	0.5	0.8	0.2	1.5
Angina	0.5	0.7	2.9	-0.1	0.7	1.7	0.1	0.2	0.8	0.1	1.1	0.8	0.8	0.0	1.3
Diabetes (mother)	0.5	0.6	1.4	-1.0	-1.2	-0.0	-0.8	-0.7	-0.0	-1.1	-0.4	0.7	0.5	-1.1	0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	2.3	-0.1	1.5	1.3	-0.2	-1.0	0.6	0.2	0.7	0.2	0.4	0.1	0.7
Sitting height	0.5	3.6	17.2	1.6	4.1	3.1	1.8	0.8	-0.9	1.9	-0.3	-1.4	-1.3	1.3	-0.8
Medication: Simvastatin	0.5	0.8	2.4	0.4	1.0	1.6	0.5	-1.2	-0.6	0.3	-0.9	-0.9	-0.8	0.5	-1.1
Falls in the last year	0.5	0.7	2.1	-0.2	-0.6	0.3	-0.5	1.2	1.2	-0.3	1.4	0.6	1.0	-0.2	1.0
Illnesses of mother	0.5	0.6	2.9	0.5	-1.0	-0.6	0.1	0.5	0.9	0.1	1.7	0.4	0.9	-0.2	1.0
Birth weight of first child	0.5	0.8	2.3	1.1	1.5	0.3	1.0	-1.2	-0.3	1.3	0.1	-0.6	-0.4	1.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	4.4	-0.6	-2.1	-1.4	-0.7	1.2	0.3	-0.6	0.3	0.5	0.4	-0.7	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.6	-0.8	-1.6	-0.7	-0.5	1.1	0.9	-0.8	0.6	0.5	0.5	-0.7	0.3
Medication: Paracetamol	0.5	0.8	2.6	-1.0	-0.1	-0.6	-1.1	1.6	0.4	-1.1	-0.1	0.7	0.4	-1.3	-0.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.1	0.8	1.0	0.9	0.8	-0.7	-0.4	0.8	-0.2	-0.7	-0.6	1.0	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	4.1	0.3	1.2	2.0	0.4	-0.8	0.7	0.5	1.4	-0.1	0.5	0.5	0.9
Medication: Omeprazole	0.5	0.6	1.6	-0.9	-0.7	-0.1	-0.7	0.2	0.7	-0.9	0.4	1.3	0.9	-0.9	1.0
Alcohol intake frequency.	0.5	1.1	4.8	0.3	-0.3	1.5	0.3	2.2	-0.7	0.2	-1.4	-0.9	-0.9	0.3	-1.1
Mineral and other dietary supplements	0.5	0.7	2.0	-0.8	-0.3	-0.0	-0.9	-1.3	-0.6	-0.8	-1.2	-0.7	-0.5	-0.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.7	-0.6	0.6	0.5	-0.6	1.4	0.9	-0.5	1.2	1.6	1.2	-1.0	1.4
Age started oral contraceptive pill	0.5	0.7	3.3	0.8	1.8	1.0	0.8	-0.3	-0.3	0.8	0.1	-0.6	-0.5	1.0	-0.3
Impedance of whole body	0.5	2.4	14.1	-1.1	-2.8	-3.8	-1.4	0.0	-0.2	-1.2	-0.7	0.2	0.0	-1.1	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.6	1.4	1.1	-0.0	-0.4	1.2	-0.9	-1.0	0.9	-0.3	-0.6	-0.6	0.9	-0.1
LDL Cholesterol	0.4	0.6	1.3	-0.7	-1.0	-0.5	-0.3	0.2	0.7	-0.6	0.9	1.1	0.9	-0.7	1.0
Multivitamins +/- minerals	0.4	0.5	2.0	0.5	0.5	-0.7	0.4	0.8	0.2	0.5	0.9	0.7	0.6	0.2	1.4
Impedance of arm (right)	0.4	1.7	5.5	-0.6	-2.3	-2.3	-0.8	-1.1	-1.1	-0.8	-1.7	-0.4	-0.8	-0.6	-1.5
Medication: Cholesterol lowering	0.4	0.7	3.6	-0.5	0.4	1.2	-0.3	-1.9	-0.5	-0.5	-1.1	-0.3	-0.4	-0.3	-1.0
Tense / ‘highly strung’	0.4	0.6	1.0	-0.9	-1.0	-0.7	-0.6	0.9	0.5	-1.0	0.1	1.0	0.6	-0.9	0.4
Loud music exposure frequency	0.4	0.4	1.9	0.5	1.4	0.7	0.6	0.6	-0.4	0.6	-0.5	-0.5	-0.6	0.5	-0.3
Glaucoma (self-reported)	0.4	0.4	1.5	0.5	-0.9	0.4	0.5	-0.0	0.9	0.3	1.2	0.3	0.6	0.2	1.0
Number of full brothers	0.4	0.5	3.9	0.7	-0.4	-2.0	0.4	0.2	-0.4	0.7	-0.1	0.3	-0.2	0.4	0.2
Worry too long after embarrassment	0.4	0.7	2.2	-0.4	-0.1	-0.2	0.1	1.0	1.2	-0.3	1.5	1.0	0.9	-0.5	1.3
Shortness of breath walking on level ground	0.4	0.5	2.7	-0.5	0.7	1.3	-0.3	-1.6	-0.0	-0.5	-0.7	0.4	-0.0	-0.1	0.0
Medication: Blood pressure	0.4	0.8	4.3	-0.9	0.2	2.1	-0.7	0.4	0.9	-0.9	0.9	0.3	0.7	-0.8	0.2
Angina (self-reported)	0.4	0.5	2.2	-0.2	0.5	1.5	-0.0	0.3	0.7	-0.1	0.9	0.7	0.7	-0.1	1.0
Heart disease (mother)	0.4	0.5	1.1	-0.0	1.0	0.7	-0.0	-0.2	1.0	0.2	1.0	0.7	0.7	-0.1	0.9
Pulse rate, automated reading	0.4	1.4	4.9	1.5	2.2	0.2	1.0	1.8	0.0	1.5	0.8	-0.2	-0.2	1.3	0.6
Family relationship satisfaction	0.4	0.5	2.2	-0.4	0.1	-0.6	-0.1	0.3	0.6	-0.4	0.5	1.2	1.0	-0.5	1.5
Supplements: Vitamin C	0.4	0.5	1.3	1.1	0.8	0.3	1.1	0.7	-0.1	1.0	0.4	0.2	0.0	0.7	0.8
Qualifications: nursing, teaching	0.4	0.7	1.7	1.1	-0.0	-0.8	0.9	0.5	0.2	1.2	1.3	-0.1	0.2	1.1	1.0
Smoking status: Current	0.4	0.7	2.6	-0.3	-1.3	-1.6	-0.5	0.9	0.6	-0.5	0.9	0.4	0.7	-0.2	0.8
Wears glasses or contact lenses	0.4	0.5	1.4	-1.1	0.1	-0.3	-1.0	0.7	0.3	-1.0	-0.0	0.1	0.2	-1.2	-0.5
Medication: Paracetamol	0.4	0.6	2.1	-0.9	0.3	-0.6	-1.0	1.5	0.5	-1.0	0.1	0.7	0.4	-1.1	-0.0
Medication: Atorvastatin	0.4	0.5	2.7	0.8	0.9	1.6	0.7	-0.6	-0.6	0.8	-0.0	0.2	-0.2	0.3	0.3
Illnesses of father: High blood pressure	0.4	0.5	2.8	-0.6	0.2	0.6	-0.5	1.7	0.7	-0.2	0.7	0.3	0.5	-0.1	0.6
Ever smoked	0.4	0.8	1.8	1.3	1.2	-0.0	1.2	0.0	-0.1	1.2	0.8	0.1	-0.2	1.4	0.6
Irritability	0.4	0.8	1.9	-1.1	-0.0	1.4	-0.7	0.5	1.0	-0.9	0.9	0.9	0.9	-0.7	0.7
Fractured/broken bones in last 5 years	0.4	0.6	1.5	0.4	1.0	0.7	0.4	-0.3	0.7	0.4	1.2	0.9	0.6	0.3	1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	-0.7	-0.6	0.2	-0.6	0.7	0.6	-0.8	0.4	1.1	0.8	-0.8	0.8
Pain experienced in last month	0.4	0.7	3.0	-0.3	-1.7	-1.2	-0.4	-0.7	-0.6	-0.6	-1.1	-0.3	-0.5	-0.4	-0.8
Heart disease (siblings)	0.4	0.5	1.1	-0.8	-0.0	-0.8	-1.0	0.4	0.6	-0.7	0.2	0.9	0.7	-0.6	0.7
Bipolar Disorder (2018)	0.3	0.5	1.5	-0.8	-1.0	1.2	-0.7	0.8	0.4	-0.8	-0.2	0.2	0.2	-0.7	-0.3
Worry (Nagel 2018)	0.3	0.6	1.3	-0.5	-0.2	0.4	-0.1	1.0	0.9	-0.5	1.0	1.0	0.9	-0.6	1.2
Crohns Disease (2017)	0.3	0.7	2.4	-0.8	-0.5	-0.1	-1.1	1.5	0.1	-0.9	-0.0	1.0	0.5	-1.0	0.6
Ulcerative Colitis (UC)	0.3	0.5	3.7	-0.1	-0.6	1.0	0.1	1.9	-0.5	-0.3	-0.9	0.1	-0.4	-0.1	-0.4
Prostate Cancer	0.3	0.4	1.4	0.8	0.7	-0.6	0.3	0.1	0.4	0.6	1.2	-0.0	0.4	0.5	0.8
Mean Putamen Volume	0.3	0.3	2.6	0.1	-1.6	-0.2	-0.1	-0.1	0.2	-0.1	0.6	0.0	0.4	0.3	0.7
Neuroticism (2016)	0.3	0.4	0.7	0.5	0.8	0.6	0.5	-0.8	-0.7	0.6	-0.5	-0.2	-0.8	0.3	-0.8
Blood Red Count	0.3	2.5	4.1	-1.6	-1.2	0.2	-2.0	2.0	2.0	-1.7	1.6	1.2	1.9	-1.6	1.3
Height	0.3	6.0	11.8	1.6	3.4	3.3	1.9	-0.9	-2.4	1.7	-2.7	-2.8	-2.6	1.8	-2.9
Allergy or Eczema	0.3	0.8	2.1	-0.8	0.2	1.4	-1.0	-0.8	-0.6	-0.9	-1.5	-0.4	-0.3	-0.7	-1.1
Hand grip strength (left)	0.3	0.7	5.2	0.4	0.6	1.3	0.3	2.3	0.2	0.3	0.8	-0.3	0.1	0.2	0.2
Relative age of first facial hair	0.3	0.7	2.3	0.5	1.5	1.4	0.7	-0.3	0.2	0.3	1.2	0.1	0.3	0.5	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.6	0.8	1.0	0.5	-0.2	-0.5	0.7	-0.2	-0.6	-0.5	0.8	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.8	0.3	1.3	1.4	0.5	0.0	0.0	0.5	0.1	-0.1	-0.2	0.5	-0.1
Hand grip strength (right)	0.3	0.8	6.5	0.2	0.8	1.0	0.3	2.5	0.5	0.2	0.8	-0.1	0.2	0.0	0.3
Maternal smoking around birth	0.3	0.4	3.5	-0.3	1.0	1.9	-0.3	0.0	-0.1	-0.4	-0.5	-0.1	-0.1	-0.3	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.5	0.6	0.6	0.7	0.4	-0.4	0.7	-0.3	-0.8	-0.6	0.7	-0.6
Impedance of leg (left)	0.3	1.5	9.6	-0.9	-2.1	-3.1	-1.0	0.2	0.2	-0.9	0.1	0.3	0.3	-1.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.9	-0.6	0.5	-0.4	-0.6	0.9	-1.0	0.3	0.9	0.7	-0.7	0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.4	-0.9	1.1	1.2	-0.8	-1.1	0.1	-0.8	-0.1	-0.0	0.2	-0.4	-0.3
Illnesses of siblings	0.3	0.4	1.4	0.8	0.4	1.2	0.7	-0.4	0.0	0.6	0.5	-0.1	0.1	0.7	0.6
Alcohol intake versus 10 years previously	0.3	0.5	2.8	0.3	0.6	-0.4	0.5	1.7	-0.8	0.3	-1.1	-0.3	-0.7	0.2	-0.5
Worrier / anxious feelings	0.3	0.5	1.2	-0.3	0.1	1.1	-0.1	1.0	0.5	-0.3	0.9	1.0	0.6	-0.6	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.3	0.4	0.9	1.5	0.7	0.1	0.3	0.6	0.4	-0.3	0.0	0.6	0.2
Number of live births	0.3	0.4	0.9	0.9	-0.0	0.6	0.9	-0.9	-0.5	0.8	-0.5	-0.2	-0.4	0.5	0.1
Happiness	0.3	0.4	3.9	0.0	2.0	0.2	0.5	-0.7	0.1	0.2	0.1	-0.1	-0.0	0.3	0.2
Prospective memory result	0.3	0.4	1.9	0.3	0.7	0.2	0.4	1.4	0.5	0.4	1.0	0.2	0.3	0.2	0.5
Standing height	0.3	3.1	12.8	1.4	3.6	1.9	1.8	0.1	-1.4	1.6	-1.1	-1.9	-1.6	1.3	-1.5
Hair/balding pattern: Pattern 4	0.3	0.6	1.5	1.2	1.0	-0.9	0.9	0.1	-0.7	1.2	-0.4	-0.6	-0.6	0.8	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	4.1	0.4	-0.1	-2.0	0.3	0.7	0.0	0.5	0.5	0.1	0.1	0.4	0.6
High blood pressure (siblings)	0.3	0.4	0.8	0.4	-0.3	-0.3	0.5	0.8	-0.7	0.5	-0.9	-0.8	-0.9	0.6	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	-0.2	-0.6	-1.2	-0.1	-0.0	0.8	-0.1	0.8	0.8	0.8	-0.3	1.2
Medication: Ibuprofen	0.3	0.3	1.2	0.2	-0.1	-0.1	0.2	0.0	-0.7	0.2	-0.7	-0.8	-0.8	0.3	-1.1
Chest pain or discomfort	0.3	0.4	2.8	-0.2	1.1	1.7	0.0	-0.2	0.1	0.1	0.2	0.4	0.2	-0.0	0.3
Age at last live birth	0.3	0.4	1.1	0.8	0.9	0.3	0.7	-1.0	-0.3	0.8	-0.0	-0.9	-0.5	0.8	-0.2
Leg pain on walking	0.3	0.4	1.1	-0.9	0.0	0.6	-0.7	-0.6	0.3	-0.9	-0.5	0.9	0.2	-1.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	2.3	0.2	0.3	-1.5	0.4	0.2	-0.5	0.3	-1.0	-0.2	-0.6	0.2	-0.5
Illnesses of siblings: Diabetes	0.3	0.3	1.1	-0.6	-1.0	-0.8	-0.6	-0.5	0.6	-0.7	0.3	0.1	0.4	-0.6	0.1
Smoking status: Previous	0.3	0.4	1.5	0.6	1.2	1.2	0.6	-0.0	0.4	0.6	0.3	0.3	-0.1	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.7	-0.6	-0.3	-0.6	-0.5	0.5	-0.8	-0.2	0.6	0.4	-0.5	0.4
Hearing aid user	0.3	0.4	1.8	-0.2	0.2	1.3	-0.4	0.3	-0.3	-0.2	-0.8	-0.6	-0.5	-0.1	-1.0
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	0.7	-1.0	-0.2	0.9	-0.6	-0.0	0.5	0.3	-0.7	-0.3	0.5	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.5	1.3	0.7	0.2	0.5	0.9	1.2	0.1	0.7	0.7	0.6	0.2	0.3	1.0
High cholesterol (Self-reported)	0.3	0.6	1.3	1.0	0.1	0.9	1.0	-1.1	-0.4	0.9	0.0	-0.5	-0.5	0.9	-0.3
Medication: Lisinopril	0.3	0.4	1.3	0.2	0.3	0.8	0.3	-0.4	0.7	0.4	1.1	0.4	0.6	0.4	1.1
Supplements: Calcium	0.3	0.4	1.2	0.1	-0.2	-0.6	-0.2	0.5	0.8	0.1	1.0	0.6	0.7	-0.0	1.1
Schizophrenia (2018)	0.2	0.5	1.9	0.6	-0.2	-1.2	0.5	0.3	0.6	0.6	1.4	-0.2	0.4	0.7	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.7	-0.5	0.1	0.0	-0.3	0.6	0.4	-0.4	0.4	0.6	0.6	-0.5	0.8
Irritable Bowel Disease (IBD)	0.2	0.5	3.9	-0.3	-0.4	0.7	-0.3	2.0	-0.6	-0.5	-0.8	0.2	-0.2	-0.3	-0.1
Major Depression (MDD)	0.2	0.3	0.7	-0.9	-0.2	-0.2	-0.9	0.0	0.4	-0.8	-0.1	0.4	0.5	-0.2	0.7
Ovarian Cancer	0.2	0.3	0.9	0.6	0.3	-0.2	0.3	-0.1	-0.8	0.6	-0.5	-0.4	-0.7	0.1	-0.9
HDL Cholesterol	0.2	0.3	1.4	-0.2	-0.1	-0.2	-0.5	-0.5	-0.5	-0.3	-1.2	-0.4	-0.5	-0.2	-0.8
Ulcerative Colitis	0.2	0.2	1.4	0.3	0.1	0.9	0.2	1.2	0.0	0.1	0.1	0.3	0.1	0.2	0.6
Blood Platelet Count	0.2	2.5	16.2	-1.1	0.8	0.2	-1.0	-4.0	-1.1	-1.1	-2.2	-0.7	-0.7	-0.5	-1.5
Severe depression (siblings)	0.2	0.2	0.8	-0.1	-0.5	0.4	0.1	-0.9	-0.1	-0.2	-0.7	-0.6	-0.4	0.3	-0.5
Impedance of leg (right)	0.2	1.0	7.9	-0.1	-1.8	-2.8	-0.2	0.0	-0.3	-0.3	-0.3	-0.3	-0.3	-0.3	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.8	-0.2	0.9	1.4	-0.4	-1.1	-0.5	-0.3	-0.9	-0.3	-0.3	-0.3	-0.5
Stomach or abdominal pain in last month	0.2	0.3	0.7	-0.1	0.2	0.8	0.1	-0.6	-0.7	0.1	-0.9	-0.5	-0.6	0.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.6	-0.6	-0.7	-0.6	0.5	-0.3	-0.6	-0.1	0.2	0.0	-0.4	-0.2
Past tobacco smoking	0.2	0.3	1.1	-0.7	-1.1	-0.6	-0.6	0.0	-0.2	-0.7	-0.4	-0.2	0.2	-0.8	-0.2
Alcohol usually taken with meals	0.2	0.3	0.9	-0.1	0.3	-0.7	-0.4	0.6	0.3	-0.0	0.8	0.6	0.6	-0.1	0.9
Nervous feelings	0.2	0.3	1.2	0.3	0.3	-0.6	0.5	-0.5	0.3	0.3	0.9	0.7	0.5	0.1	1.1
Had menopause	0.2	0.2	0.9	0.4	0.9	0.7	0.4	0.6	-0.0	0.5	0.2	-0.4	-0.3	0.6	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.2	0.4	1.5	0.4	0.5	0.4	-1.2	0.4	-1.0	-0.5	-0.9	0.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	4.3	-0.4	-2.1	-0.1	-0.6	0.0	0.2	-0.4	0.3	0.4	0.1	-0.6	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	1.8	-0.5	0.8	1.4	-0.1	0.0	0.6	-0.4	0.0	0.5	0.2	-0.6	0.0
Depression (self-reported)	0.2	0.3	1.0	-0.7	0.4	-1.0	-0.5	-0.5	0.3	-0.6	-0.3	0.4	0.3	-0.5	0.2
Lung cancer (father)	0.2	0.3	1.4	-0.4	-0.3	1.2	-0.3	1.1	0.3	-0.4	-0.2	0.2	0.1	-0.3	0.1
Pulse wave Arterial Stiffness index	0.2	0.2	1.8	0.2	0.4	0.2	0.3	-1.3	-0.1	0.4	0.1	-0.1	0.1	0.6	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.7	-0.2	1.3	0.9	0.2	0.3	-0.2	0.0	-0.5	0.2	-0.2	-0.1	-0.1
Age at first live birth	0.2	0.3	0.8	0.1	0.4	0.1	-0.0	-0.6	-0.6	0.1	-0.9	-0.7	-0.6	0.2	-0.9
Pulse wave peak to peak time	0.2	0.2	1.4	-0.1	-0.1	-0.0	-0.2	1.2	-0.1	-0.3	-0.3	-0.0	-0.3	-0.5	-0.6
Health satisfaction	0.2	0.3	1.7	-0.2	1.3	0.7	0.3	-0.1	-0.3	0.1	-0.7	-0.0	-0.2	0.3	0.2
Suffer from ‘nerves’	0.2	0.3	0.9	0.7	0.4	0.1	0.9	0.7	-0.6	0.6	-0.0	-0.3	-0.6	0.7	-0.3
Overall health rating	0.2	0.3	0.9	-0.7	0.9	0.9	-0.3	-0.7	-0.3	-0.4	-0.8	-0.2	-0.2	-0.4	-0.5
Knee pain experienced in last month	0.2	0.3	1.2	0.4	0.2	1.1	0.8	-0.8	-0.2	0.4	0.0	-0.1	-0.2	0.6	0.2
Average weekly red wine intake	0.2	0.3	0.9	0.9	-0.5	0.4	0.8	-0.5	-0.3	0.9	0.4	-0.3	-0.2	0.8	0.3
Eye problems/disorders: Cataract	0.2	0.2	0.9	-0.4	-0.8	-0.3	-0.3	-0.2	-0.3	-0.5	-0.9	0.2	0.0	-0.4	-0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	-0.0	-0.8	-0.1	-0.1	0.7	0.7	-0.0	0.9	-0.0	0.5	0.1	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	-0.4	-0.3	-0.8	-0.3	-0.1	-0.7	-0.3	-1.1	-0.4	-0.7	-0.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	0.4	-0.0	-0.5	0.5	-0.8	-0.5	0.6	-0.4	-0.2	-0.6	0.3	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.7	0.5	-0.4	0.7
Coronary Artery Disease (CAD)	0.1	0.1	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.6	-0.5	-0.1	-1.0
Crohns Disease (2012)	0.1	0.2	1.1	0.1	-0.0	0.4	0.0	-0.0	-0.8	-0.1	-1.0	-0.4	-0.5	-0.2	-0.7
HbA1C	0.1	0.2	0.7	-0.5	-0.3	-0.4	-0.2	-0.9	-0.1	-0.6	-0.0	-0.2	0.1	-0.2	-0.6
Schizophrenia (2014)	0.1	0.2	0.5	0.3	-0.7	-0.7	0.5	0.1	0.2	0.3	0.5	-0.1	0.1	0.4	0.3
Triglycerides	0.1	0.2	1.1	-0.4	-0.3	1.1	-0.3	0.8	0.3	-0.3	0.6	0.1	0.4	-0.2	0.1
Waist Hip Ratio (WHR)	0.1	0.5	1.7	-0.6	-1.2	1.3	-0.2	-0.2	0.9	-0.6	0.4	0.4	0.6	-0.5	0.4
Tanning	0.1	0.6	1.6	-0.6	-1.0	0.0	-0.8	0.4	0.7	-0.6	0.6	1.2	0.9	-0.8	1.0
Hearing difficulty/problems: Yes	0.1	0.2	0.9	-0.5	-0.1	0.3	-0.2	-1.0	-0.1	-0.4	-0.2	-0.3	-0.2	-0.1	-0.5
Relative age voice broke	0.1	0.1	0.7	0.1	0.8	-0.1	0.2	-0.4	0.0	-0.1	0.1	0.0	-0.1	-0.0	-0.1
Number of incorrect matches in round	0.1	0.2	0.5	0.7	0.1	0.2	0.5	0.5	0.4	0.6	0.7	0.3	0.3	0.2	0.6
Forced vital capacity (FVC)	0.1	0.3	2.7	-0.3	1.6	0.2	-0.2	0.5	-0.2	-0.3	0.1	0.4	0.2	-0.7	0.1
Qualifications: None of the above	0.1	0.3	0.7	-0.5	0.8	0.6	-0.4	-0.4	0.5	-0.6	0.0	0.8	0.4	-0.7	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	1.4	-0.1	-1.2	0.2	-0.3	-0.0	0.2	-0.0	-0.2	0.1	-0.0	0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.1	0.3	-0.6	-0.1	-0.6	-0.2	-0.1	0.3	0.1	-0.0	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.6	-0.1	1.3	0.4	0.0	0.8	-1.0	-0.0	-1.0	-0.2	-0.5	-0.3	-0.7
Pulse wave reflection index	0.1	0.1	0.3	-0.3	-0.4	0.5	0.0	0.1	0.1	-0.2	-0.0	0.4	0.2	-0.2	0.4
Headache pain in last month	0.1	0.2	1.8	-0.6	1.3	0.4	-0.5	0.1	0.2	-0.2	-0.1	-0.3	0.1	-0.1	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	2.0	-0.4	1.4	0.3	-0.3	0.8	-0.2	-0.3	-0.2	0.4	0.2	-0.8	0.0
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.1	0.4	0.3	-0.4	0.2	0.4	-0.1	0.4	0.6	0.4	-0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.6	-0.3	-0.5	0.4	-0.3	-0.8	0.3	-0.2	0.2	0.4	0.3	-0.3	0.3
Osteoarthritis (self-reported)	0.1	0.1	0.5	0.2	0.5	0.7	0.3	-0.0	-0.4	0.2	-0.1	0.1	-0.2	-0.0	-0.3
Guilty feelings	0.1	0.2	1.9	0.1	0.0	0.2	0.5	-1.4	-0.0	0.1	0.4	0.3	0.0	0.2	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.8	0.4	-0.9	0.2	0.3	-0.0	0.4	0.1	0.6	0.1	0.1	0.1	0.1
Ever depressed for a whole week	0.1	0.1	1.2	-0.1	1.1	0.4	-0.2	-0.2	-0.1	-0.1	-0.2	-0.2	-0.1	-0.0	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.2	0.4	-0.1	0.2	0.5	-0.1	-0.1	0.4	0.0	0.0	-0.2	0.4	-0.1
Systolic Blood Pressure	0.0	0.1	1.1	-0.1	0.2	1.0	-0.2	0.1	-0.1	0.3	-0.1	-0.3	-0.2	0.3	-0.2
Hair Pigment	0.0	0.2	0.8	0.4	-0.5	0.9	0.5	0.2	0.1	0.4	0.7	0.3	0.2	0.3	0.6
Qualifications: College or University degree	0.0	0.1	0.9	-0.2	-0.2	-0.1	-0.3	-1.0	-0.1	-0.2	0.3	-0.1	0.1	-0.1	0.0
Unable to work because of sickness or disability	0.0	0.0	0.3	-0.2	-0.5	-0.1	0.1	-0.2	0.1	-0.1	-0.1	0.2	-0.0	0.0	0.2

Hub : Genes

TEAD2

Models

Trait associations