TWAS hub - TENC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2400	0.0440	3.0e-12	0.151	0.104	0.166	0.136	0.173	5.4e-18	1.2e-12	9.8e-20	3.2e-16	1.5e-20
2	GTEx	Adipose Visceral Omentum	0.2100	0.0790	3.1e-03	-0.003	NA	-0.005	NA	-0.001	5.0e-01	NA	6.9e-01	NA	3.5e-01
3	GTEx	Artery Aorta	0.1770	0.0700	4.0e-03	0.176	NA	0.179	NA	0.181	5.7e-10	NA	4.1e-10	NA	2.9e-10
4	GTEx	Artery Tibial	0.2487	0.0616	1.6e-05	0.138	NA	0.180	NA	0.181	6.0e-11	NA	4.4e-14	NA	4.1e-14
5	GTEx	Brain Cerebellar Hemisphere	0.5500	0.1200	1.5e-03	0.271	NA	0.248	NA	0.328	1.2e-07	NA	4.8e-07	NA	3.4e-09
6	GTEx	Brain Cerebellum	0.6050	0.0930	1.5e-05	0.406	NA	0.434	NA	-0.010	3.5e-13	NA	3.3e-14	NA	8.6e-01
7	GTEx	Esophagus Muscularis	0.3740	0.0760	1.3e-05	0.170	NA	0.152	NA	0.117	1.6e-10	NA	1.7e-09	NA	1.5e-07
8	GTEx	Skin Not Sun Exposed Suprapubic	0.2290	0.0660	1.3e-03	0.081	NA	0.059	NA	0.043	3.4e-05	NA	3.7e-04	NA	2.1e-03
9	TCGA	Bladder Urothelial Carcinoma	0.0630	0.0290	1.2e-03	0.023	0.030	0.022	NA	0.025	4.8e-03	1.4e-03	5.1e-03	NA	3.2e-03
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0827	0.0311	1.2e-07	0.034	0.077	0.067	NA	0.064	8.6e-05	5.1e-09	4.7e-08	NA	1.1e-07
11	TCGA	Lung Adenocarcinoma	0.0528	0.0286	1.6e-03	0.005	0.019	0.016	NA	0.008	8.2e-02	2.1e-03	5.1e-03	NA	3.1e-02
12	TCGA	Lung Squamous Cell Carcinoma	0.0954	0.0439	7.0e-06	0.061	0.049	0.050	NA	0.056	1.7e-07	3.1e-06	2.4e-06	NA	5.8e-07
13	TCGA	Thyroid Carcinoma	0.1180	0.0460	2.7e-06	0.004	0.043	0.037	NA	0.024	1.1e-01	5.0e-05	1.6e-04	NA	1.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Exposure to tobacco smoke at home	4.7	5.2	9.9	2.9	2.5	2.8	3.1	3.0	3.0	2.7	-0.7	1.1	1.0	0.8	2.6	0.8
Mouth/teeth dental problems: Loose teeth	4.3	5.1	7.4	2.6	2.4	2.4	2.7	2.4	2.1	2.7	-1.1	2.2	1.7	2.1	2.4	2.0
Hand grip strength (left)	4.1	10.9	15.8	-3.8	-3.6	-4.0	-3.1	-3.4	-3.4	-3.7	0.3	-3.3	-3.8	-2.8	-3.8	-1.9
Diastolic blood pressure, automated reading	3.8	11.7	30.2	4.2	3.4	4.0	5.5	4.8	4.7	3.4	2.2	-0.5	1.2	-0.6	3.6	0.8
Exposure to tobacco smoke outside home	3.7	5.0	8.7	3.0	2.2	3.0	2.7	2.7	2.7	2.3	-0.8	1.0	2.2	0.7	2.6	1.4
Mean time to correctly identify matches	3.2	6.2	8.3	2.8	1.6	2.4	2.4	2.5	2.4	2.6	2.9	2.3	2.8	2.0	2.7	2.7
Commuting to job workplace: Cycle	3.1	3.8	5.4	-2.3	-1.8	-2.2	-2.2	-2.1	-2.1	-2.0	-1.1	-1.1	-2.2	-1.4	-2.2	-1.9
Had menopause	3.0	3.8	8.3	2.0	1.2	1.9	1.2	1.5	1.7	2.2	-0.2	2.9	2.3	2.4	2.2	1.9
Average weekly beer plus cider intake	3.0	4.3	8.0	-1.8	-1.7	-2.1	-1.4	-2.0	-2.0	-2.4	-0.8	-2.4	-2.3	-2.2	-2.3	-2.8
Hearing difficulty/problems with background noise	2.9	4.6	7.3	-2.1	-1.4	-2.3	-1.8	-2.0	-2.2	-2.2	1.0	-2.6	-2.5	-2.3	-2.7	-1.9
Age started oral contraceptive pill	2.7	3.3	9.5	1.6	0.9	1.4	0.9	1.2	1.0	1.8	1.0	3.1	2.2	2.9	1.5	2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	5.8	2.1	2.1	2.0	2.3	2.1	2.4	2.0	-0.1	0.9	0.7	0.0	2.1	1.1
Systolic blood pressure, automated reading	2.5	7.2	17.6	2.2	1.7	2.4	4.2	3.1	3.4	1.5	3.9	-2.0	-0.3	-3.3	2.3	-1.9
Hand grip strength (right)	2.5	6.8	10.3	-3.2	-3.2	-3.2	-2.8	-2.8	-2.9	-2.8	-0.1	-2.2	-2.8	-1.7	-3.0	-0.9
Smoking status: Current	2.4	3.8	7.0	-2.3	-2.3	-2.4	-2.5	-2.6	-2.6	-2.3	-1.1	-0.1	-0.8	-0.5	-2.1	-0.8
Illnesses of father: High blood pressure	2.4	3.0	7.6	1.7	1.8	1.9	2.7	2.2	2.8	1.5	1.2	-1.2	-0.4	-1.1	1.7	-0.7
Myopia	2.4	3.5	7.8	-1.5	-1.4	-1.8	-1.3	-1.5	-1.4	-2.1	-1.1	-2.8	-2.4	-1.5	-1.9	-2.5
Schizophrenia vs Biploar Disorder	2.3	3.1	7.4	1.5	1.5	1.7	0.9	1.2	1.0	1.9	0.3	2.5	1.4	2.7	1.9	2.6
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	8.4	-1.6	-1.8	-1.5	-1.4	-1.4	-1.2	-2.0	-1.6	-2.4	-2.1	-2.6	-1.8	-2.9
Hearing difficulty/problems: Yes	2.2	3.3	5.8	-1.7	-1.3	-1.8	-1.5	-1.6	-1.8	-1.7	1.0	-2.3	-2.4	-2.4	-1.9	-1.8
Systolic Blood Pressure	2.1	10.4	26.1	2.0	2.0	2.3	5.1	3.5	4.0	0.9	3.0	-3.5	-2.0	-4.8	1.9	-3.8
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	6.3	2.3	1.2	1.8	2.5	2.3	2.2	1.8	-1.3	0.0	0.8	0.0	1.5	0.6
Reaction Time	2.0	3.9	5.9	2.4	1.0	1.8	1.9	2.0	1.8	2.0	1.7	2.0	2.2	2.1	2.1	2.2
Ever highly irritable/argumentative for 2 days	2.0	2.4	5.6	-1.2	-1.7	-1.4	-0.9	-1.1	-1.1	-1.8	-0.6	-2.0	-1.6	-2.4	-1.3	-2.0
Fasting Glucose	1.9	2.3	5.2	-1.6	-1.2	-1.8	-2.3	-1.9	-2.1	-1.5	-0.9	-0.5	-1.1	0.0	-1.8	-1.2
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	5.8	1.1	2.4	1.4	1.9	1.7	1.5	1.3	2.3	0.0	0.4	-0.3	1.3	0.3
Eye problems/disorders: None of the above	1.9	2.2	5.2	-1.2	-1.6	-1.2	-1.2	-1.2	-1.2	-1.7	-0.8	-2.3	-1.5	-0.9	-1.7	-2.1
Chest pain or discomfort	1.9	2.7	6.0	-1.5	-1.6	-1.6	-0.9	-1.3	-1.5	-1.9	-1.1	-1.8	-1.7	-1.6	-1.9	-2.4
Eye problems/disorders: Cataract	1.9	2.2	4.6	1.1	1.9	1.2	0.9	1.0	0.9	1.6	1.8	1.7	1.6	1.4	1.5	2.1
Alzheimer’s Disease (in mother)	1.8	2.2	4.5	2.1	1.5	1.7	2.0	1.9	1.7	1.7	0.1	0.9	1.0	0.2	1.5	0.9
Financial situation satisfaction	1.7	2.1	7.8	-0.5	-0.5	-1.0	0.2	-0.3	-0.4	-1.2	0.6	-2.6	-1.9	-2.8	-1.0	-2.0
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.6	-1.7	-1.3	-1.5	-1.7	-1.8	-1.5	-1.9	0.3	-1.5	-0.8	-1.0	-1.6	-0.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.6	1.8	1.3	1.6	1.8	1.8	1.9	1.7	0.7	1.0	1.2	0.7	1.6	1.2
Severe depression (siblings)	1.6	1.8	4.3	-1.0	-0.6	-1.0	-0.4	-0.5	-0.7	-1.2	1.6	-1.9	-1.9	-1.7	-1.3	-2.1
Stomach or abdominal pain in last month	1.6	2.1	6.5	-1.3	-1.7	-1.2	-1.1	-0.9	-1.2	-1.4	2.5	-1.8	-1.0	-1.7	-1.1	-0.8
Bipolar Disorder (2018)	1.5	2.4	5.9	-1.8	-1.4	-1.5	-1.4	-1.5	-1.1	-1.7	1.2	-2.1	-0.8	-2.4	-1.3	-0.9
Bipolar Disorder (2011)	1.5	1.5	2.8	-1.7	-1.4	-1.4	-1.1	-1.3	-1.1	-1.5	0.4	-0.8	-1.1	-1.2	-1.4	-0.8
Diabetes (father)	1.5	1.8	5.2	-1.8	-1.4	-1.5	-2.3	-1.9	-2.0	-1.1	0.3	-0.0	-0.4	-0.9	-0.9	-0.0
Current tobacco smoking	1.5	2.4	4.4	-1.9	-2.0	-1.9	-1.9	-2.1	-2.1	-1.9	-0.8	0.0	-0.4	-0.6	-1.6	-0.6
High blood pressure	1.5	4.3	11.4	0.9	1.1	0.9	2.9	1.9	2.1	-0.0	2.3	-2.8	-1.8	-3.4	0.6	-2.8
Hair/balding pattern: Pattern 4	1.5	3.7	7.1	-2.6	-1.9	-2.4	-2.7	-2.4	-2.3	-1.8	1.3	-1.4	-1.2	-0.8	-2.2	0.1
Pulse wave peak to peak time	1.5	1.8	3.9	1.3	1.2	1.8	1.8	1.7	2.0	1.5	-0.7	0.8	0.8	0.6	1.7	0.6
Hypertension (Self-reported)	1.5	4.1	10.5	1.4	1.7	1.3	3.2	2.3	2.4	0.4	1.9	-2.2	-1.4	-2.8	0.9	-2.5
Serious illness, injury or assault to yourself	1.4	1.7	4.7	1.0	2.1	0.8	0.7	0.8	0.7	1.2	0.0	1.9	1.4	2.2	0.9	1.4
Wheeze or whistling in the chest in last year	1.4	2.5	6.4	-1.1	-1.4	-1.4	-0.6	-1.1	-1.3	-1.6	-0.4	-2.3	-2.0	-2.0	-1.7	-2.5
Loneliness, isolation	1.4	1.9	4.6	-1.3	-1.7	-1.2	-0.6	-1.0	-0.9	-1.4	-0.4	-1.6	-2.1	-1.7	-1.2	-1.8
Pain type(s) experienced in last month: Hip pain	1.4	1.7	4.5	1.7	1.8	1.3	2.1	1.8	1.8	1.4	0.2	-0.5	-0.1	-0.4	1.0	-0.4
Risk taking	1.4	2.0	3.4	-1.5	-1.3	-1.8	-1.1	-1.4	-1.3	-1.6	-1.8	-1.3	-1.5	-1.2	-1.6	-0.3
Blood Platelet Count	1.3	14.8	25.4	-4.1	-2.9	-4.3	-3.2	-4.0	-3.4	-4.2	-0.3	-3.9	-5.0	-3.5	-4.5	-4.4
Supplements: Glucosamine	1.3	1.7	2.6	1.4	1.1	1.0	1.4	1.3	1.2	1.5	1.1	1.6	1.3	1.2	1.2	1.6
Medication: Blood pressure	1.3	2.2	12.1	0.1	-0.1	0.1	1.5	0.8	0.9	-0.5	0.7	-2.7	-1.6	-3.5	0.0	-1.7
Vascular/heart problems diagnosed by doctor	1.3	3.5	9.7	-0.7	-0.8	-0.6	-2.5	-1.4	-1.8	0.3	-2.3	2.6	1.8	3.1	-0.4	2.7
Ovarian Cancer	1.2	1.6	5.5	-1.7	-0.1	-1.5	-2.3	-1.8	-1.6	-1.1	0.4	-0.2	0.2	-0.4	-1.2	0.8
Triglycerides	1.2	1.9	3.0	-1.7	-0.9	-1.7	-1.6	-1.7	-1.5	-1.5	-1.2	-1.3	-1.2	-1.1	-1.5	-0.5
Relative age of first facial hair	1.2	2.4	4.4	2.1	2.0	1.8	1.8	1.7	2.0	1.5	0.5	0.6	1.6	0.8	1.4	1.4
Pulse wave Arterial Stiffness index	1.2	1.4	3.2	-1.0	-1.1	-1.6	-1.5	-1.4	-1.8	-1.3	0.7	-0.8	-0.8	-0.5	-1.5	-0.6
Loud music exposure frequency	1.2	1.3	2.9	0.8	1.1	0.8	0.9	0.8	0.8	1.0	1.2	1.7	1.1	1.3	0.9	1.7
Medication: Ibuprofen	1.2	1.5	3.8	-1.0	-0.1	-1.0	-0.8	-1.0	-1.3	-1.4	0.0	-2.0	-1.3	-0.9	-1.6	-1.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	6.0	-1.3	-2.5	-1.1	-0.9	-1.1	-0.9	-1.3	-0.2	-1.2	-0.9	-1.3	-1.0	-0.7
Ever taken oral contraceptive pill	1.2	1.3	3.4	1.6	0.9	1.2	1.8	1.7	1.4	1.1	0.5	0.3	0.2	0.6	1.0	0.8
Medication: Bendroflumethiazide	1.2	1.8	5.9	1.4	0.5	1.3	2.4	1.8	2.0	0.9	1.7	-0.2	-0.1	-0.6	1.3	-0.6
Alzheimer’s Disease (including proxy)	1.1	1.6	3.5	1.9	1.7	1.4	1.4	1.5	1.1	1.6	0.5	0.8	1.0	0.3	1.1	0.9
Crohns Disease (2017)	1.1	2.3	4.1	1.7	1.1	1.2	1.4	1.4	1.5	1.8	-0.3	2.0	1.7	1.9	1.2	1.8
Cardiovascular Disease	1.1	3.5	12.8	0.4	0.4	0.6	2.5	1.5	1.9	-0.4	0.9	-2.8	-1.9	-3.6	0.4	-2.7
Average weekly fortified wine intake	1.1	1.3	2.8	1.3	0.7	1.5	1.2	1.5	1.7	1.3	1.0	0.5	0.2	0.3	1.6	0.8
High blood pressure (mother)	1.1	1.5	5.9	-0.7	-0.6	-0.5	-0.1	-0.1	-0.3	-1.1	-0.7	-2.1	-1.6	-2.4	-1.0	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.7	-0.7	-1.1	-1.0	-0.1	-0.6	-0.8	-1.5	2.4	-1.5	-1.7	-1.9	-1.1	-1.1
Worrier / anxious feelings	1.1	2.1	4.6	-1.4	-2.1	-1.6	-1.4	-1.7	-1.7	-1.9	-0.5	-1.0	-0.9	-1.1	-1.6	-1.1
Medication: Cholesterol lowering	1.1	1.7	5.2	-1.2	-0.8	-1.4	-0.7	-1.0	-0.8	-1.4	1.3	-1.6	-1.2	-2.3	-1.1	-1.3
Blood clot in the leg (DVT)	1.1	1.4	5.8	-1.0	-0.9	-0.8	-1.7	-1.0	-1.2	-0.4	-2.4	1.2	-0.2	1.5	-0.8	-0.2
Breast cancer (self-reported)	1.1	1.3	2.9	0.8	1.3	1.1	1.7	1.4	1.6	1.2	-1.5	0.5	0.2	0.2	1.4	-0.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.0	1.4	1.1	1.2	1.2	1.3	1.0	1.4	0.7	0.7	0.8	1.4	1.3	0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.8	-0.9	-0.9	-0.8	-1.6	-1.0	-1.4	-0.5	-2.4	1.2	-0.2	1.6	-0.8	-0.0
Ulcerative Colitis	1.0	1.5	2.6	1.2	0.2	1.3	0.8	1.2	1.2	1.2	-1.2	1.6	1.6	1.5	1.4	1.0
Smoking Status	1.0	2.4	4.7	-1.9	-1.5	-1.8	-2.2	-2.1	-2.2	-1.9	-0.1	-0.9	-0.3	-0.8	-1.6	-0.5
Sensitivity / hurt feelings	1.0	1.7	4.4	1.8	1.7	1.4	2.1	1.8	1.6	1.4	0.7	0.4	0.3	0.4	1.0	0.0
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	0.8	1.2	1.5	1.2	1.2	1.3	1.4	-0.3	0.5	0.5	-0.4	1.6	0.5
Angina	1.0	1.3	3.4	-1.2	-0.7	-1.2	-0.5	-1.1	-0.9	-1.1	1.8	-0.9	-1.4	-1.2	-1.0	-1.0
Medication for hormone replacement therapy	1.0	1.1	2.7	-0.9	-1.6	-1.4	-1.3	-1.4	-1.2	-1.2	-0.2	0.0	-0.4	-0.4	-1.3	0.3
Hayfever, allergic rhinitis or eczema	1.0	2.1	5.8	1.6	0.3	1.1	0.5	1.0	0.8	1.4	-0.1	2.3	1.7	2.4	0.9	2.3
Number of children fathered	1.0	1.2	2.2	-1.1	-0.1	-1.2	-1.1	-1.0	-1.2	-1.1	1.5	-1.0	-0.9	-0.7	-1.4	-1.2
Illnesses of siblings: Diabetes	1.0	1.2	3.2	-1.2	-0.7	-1.4	-0.9	-1.2	-1.2	-1.4	1.8	0.0	-0.7	-0.1	-1.3	-0.7
Mood swings	1.0	1.9	3.8	-1.4	-1.9	-1.3	-0.9	-1.2	-1.0	-1.6	-0.4	-1.5	-1.5	-1.6	-1.3	-1.3
Mother’s age at death	1.0	1.3	2.5	1.0	1.5	1.4	0.8	1.1	1.0	1.6	0.4	0.5	1.2	0.1	1.6	1.3
Waist Hip Ratio (WHR)	0.9	4.1	8.8	1.9	1.5	2.1	3.0	2.4	2.7	1.3	2.5	-1.2	0.1	-2.4	2.2	-1.2
Ever had hysterectomy (womb removed)	0.9	1.1	4.7	0.4	0.6	0.1	0.0	0.0	-0.0	0.5	-2.2	1.8	0.9	1.8	0.2	1.0
Medication: Co-codamol	0.9	1.1	3.1	1.2	1.1	0.8	0.1	0.6	0.4	0.7	-1.0	1.8	1.6	1.6	0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	1.1	0.6	1.1	1.5	1.2	1.3	1.1	0.6	0.9	0.5	1.1	1.1	0.8
Qualifications: None of the above	0.9	2.0	4.9	1.2	1.1	1.3	1.3	1.2	1.1	1.2	2.2	1.5	1.9	0.5	1.9	1.3
Hair/balding pattern: Pattern 3	0.9	1.4	2.9	1.2	0.6	1.6	0.9	1.4	0.9	1.3	-0.6	1.6	1.0	1.3	1.7	-0.0
Length of working week for main job	0.9	1.0	4.1	0.8	0.3	0.9	0.5	0.6	0.5	0.6	-2.0	0.9	1.3	0.5	0.9	1.4
Medication: Paracetamol	0.9	1.5	3.5	1.5	0.8	1.3	0.9	1.2	1.0	1.2	-1.9	1.0	0.9	1.5	1.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	8.2	0.4	0.3	0.6	-0.6	0.0	-0.1	0.8	-0.7	2.2	1.5	2.9	0.4	1.3
Health satisfaction	0.9	1.2	4.2	-0.9	-1.3	-1.0	-0.3	-0.7	-0.7	-1.1	0.0	-1.6	-1.0	-2.0	-0.8	-1.2
Long-standing illness, disability or infirmity	0.9	1.4	2.2	1.5	1.4	1.1	1.5	1.5	1.0	1.4	-1.2	1.1	0.6	0.4	1.2	0.6
Qualifications: nursing, teaching	0.9	1.3	3.7	-1.1	-0.7	-1.0	-1.2	-0.9	-1.0	-1.0	-1.4	-0.6	-1.7	-0.3	-1.2	-1.9
Hearing aid user	0.9	1.0	2.1	1.2	0.8	1.3	1.5	1.4	1.3	1.2	0.2	0.1	-0.2	-0.0	1.3	0.1
High cholesterol (Self-reported)	0.9	1.7	8.4	-0.9	-1.8	-1.1	-0.4	-0.8	-0.7	-1.3	-0.5	-1.9	-0.6	-2.9	-0.6	-0.7
Irritability	0.9	1.5	4.6	-0.7	-1.6	-0.4	0.4	-0.1	0.1	-1.1	-0.3	-1.8	-1.5	-2.1	-0.3	-2.0
Basal cell carcinoma (self-reported)	0.9	1.1	2.1	-1.1	-1.1	-1.2	-1.3	-1.5	-1.1	-1.3	-0.5	-0.4	-0.0	-0.6	-1.2	-1.2
Crohns Disease (2012)	0.8	1.2	2.2	1.3	0.4	1.2	1.0	1.3	1.2	1.4	0.3	1.5	0.9	1.1	1.4	0.7
HbA1C	0.8	0.8	1.6	-0.8	-0.5	-1.2	-0.5	-0.8	-0.9	-1.0	-0.0	-1.3	-1.2	-1.1	-0.9	-0.9
Allergy	0.8	1.8	5.3	-1.4	0.1	-0.9	-0.1	-0.7	-0.7	-1.3	0.8	-2.3	-1.7	-2.1	-0.8	-2.0
Medication: Ramipril	0.8	1.0	6.2	0.2	-0.4	0.2	1.2	0.7	0.6	-0.2	1.1	-1.5	-0.5	-2.5	0.3	-0.7
Medication: Simvastatin	0.8	1.1	4.9	-0.0	0.0	-0.2	0.9	0.4	0.5	-0.4	2.2	-1.6	-0.6	-2.2	-0.0	-0.7
Illnesses of siblings	0.8	1.1	2.3	-1.1	-1.1	-1.0	-1.4	-1.1	-1.1	-0.9	-0.9	-1.5	-0.3	-1.0	-1.0	0.2
Pulse wave reflection index	0.8	0.9	3.2	-0.9	-0.4	-1.2	-1.8	-1.4	-1.4	-0.8	0.8	0.1	0.0	0.1	-1.2	0.1
Glaucoma (self-reported)	0.8	0.9	2.2	-0.8	-1.4	-0.8	-1.0	-1.1	-1.0	-0.8	1.5	-0.1	0.2	-1.4	-0.4	0.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	1.0	0.1	0.8	1.1	1.0	0.9	1.0	-0.3	1.5	1.0	0.6	1.2	1.1
High blood pressure (siblings)	0.8	1.1	2.7	1.1	1.1	1.4	1.6	1.4	1.6	0.9	0.3	0.2	-0.2	-0.2	1.2	-0.6
Worry too long after embarrassment	0.8	1.3	2.7	1.6	1.6	1.2	1.4	1.3	1.1	1.2	1.0	0.5	1.2	0.1	1.1	0.7
Angina (self-reported)	0.8	1.1	3.9	-1.0	-0.6	-1.1	-0.4	-0.9	-0.8	-1.0	2.0	-0.9	-1.2	-1.1	-1.0	-0.9
Heart disease (mother)	0.8	0.9	5.4	1.0	0.8	0.6	0.6	0.5	0.5	0.6	2.3	1.0	0.8	1.3	0.3	0.4
Alcohol intake frequency.	0.8	1.9	5.2	1.7	1.2	1.3	1.7	1.6	1.2	1.3	-2.3	0.8	-0.1	1.8	0.9	-0.5
Family relationship satisfaction	0.8	1.0	4.5	0.1	-0.7	-0.3	0.6	0.3	0.2	-0.8	-0.3	-2.1	-0.5	-1.9	-0.6	-1.7
Smoking status: Previous	0.8	1.1	2.4	1.2	1.5	1.2	1.3	1.3	1.4	1.0	0.6	-0.2	0.4	0.3	1.2	0.9
Mineral and other dietary supplements	0.8	1.1	2.5	-1.3	-1.0	-0.8	-1.6	-1.3	-1.3	-1.1	-0.4	-0.9	-0.3	-0.9	-0.9	-0.8
Osteoarthritis (self-reported)	0.8	1.0	3.2	1.3	1.1	0.8	0.6	0.6	0.6	0.9	0.3	1.8	1.0	1.4	1.0	0.8
Schizophrenia (2018)	0.7	1.4	3.6	1.3	1.2	1.5	1.2	1.3	1.6	1.1	1.9	0.2	0.6	0.5	1.4	0.4
Irritable Bowel Disease (IBD)	0.7	1.6	4.3	1.3	0.1	0.6	0.8	0.8	0.9	1.3	-1.7	2.1	1.7	2.0	0.8	1.1
Blood Red Count	0.7	6.6	15.6	-3.1	-2.6	-3.2	-3.9	-3.4	-3.7	-2.5	-2.0	0.5	-1.2	0.4	-2.5	0.0
Lung FEV1/FVC ratio	0.7	3.4	8.9	1.6	2.7	1.1	0.9	1.1	0.9	2.0	1.0	2.2	1.7	2.8	0.9	3.0
Lung FVC	0.7	3.5	8.0	1.8	2.2	1.7	2.4	2.2	2.2	2.0	-2.8	1.2	0.7	1.6	1.5	0.7
Supplements: Zinc	0.7	0.8	1.8	1.3	0.3	1.0	1.3	1.2	1.2	0.8	0.8	0.7	-0.1	0.5	0.8	-0.3
Impedance of leg (right)	0.7	3.5	18.8	1.5	0.4	1.8	1.7	1.9	2.5	1.3	4.3	-0.5	0.7	-1.6	1.9	-0.2
Impedance of leg (left)	0.7	3.4	23.3	1.2	0.2	1.4	1.5	1.6	2.2	0.8	4.8	-0.9	0.3	-2.0	1.5	-0.7
Alcohol usually taken with meals	0.7	1.1	3.1	0.8	0.7	0.7	0.8	1.0	1.2	1.4	0.4	1.8	0.2	1.2	1.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.3	1.0	1.2	1.2	0.7	1.1	1.1	1.6	2.3	0.8	0.9	1.3	1.2	1.6
Mouth/teeth dental problems	0.7	1.0	2.1	-1.4	-1.4	-0.9	-1.4	-1.2	-1.1	-0.9	-1.4	0.1	-0.5	0.2	-0.7	-0.7
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.4	0.8	0.3	0.5	0.7	0.7	0.6	0.8	1.2	1.5	1.0	1.3	0.5	1.4
Neuroticism score	0.7	1.4	3.3	-0.9	-1.3	-0.9	-0.3	-0.8	-0.8	-1.4	0.1	-1.6	-1.2	-1.7	-1.1	-1.8
Impedance of arm (right)	0.7	3.4	7.2	2.4	1.1	2.3	1.9	2.2	2.7	1.9	1.0	1.4	1.8	0.9	2.3	0.7
Number of live births	0.7	0.9	2.9	0.8	-0.1	0.5	-0.2	0.1	-0.1	0.6	-1.1	1.6	1.7	1.4	0.7	1.4
Happiness	0.7	0.8	4.0	-0.3	-1.2	-0.5	-0.1	-0.3	-0.3	-0.7	-0.7	-1.3	-0.7	-1.1	-0.6	-2.0
Impedance of arm (left)	0.7	3.1	6.9	2.4	0.9	2.2	1.9	2.1	2.6	1.8	0.5	1.4	1.7	0.9	2.2	0.8
Birth weight	0.7	1.6	3.5	1.5	1.9	1.2	1.6	1.4	1.6	1.3	-1.6	-0.2	0.9	0.4	0.8	0.8
Neck or shoulder pain in last month	0.7	1.0	2.2	-1.1	-1.0	-1.3	-0.6	-0.9	-1.0	-1.0	1.2	-0.4	-1.5	-0.7	-1.1	-0.6
Number of full sisters	0.7	0.8	1.7	-0.8	-0.4	-1.1	-0.1	-0.8	-0.7	-0.9	0.1	-1.3	-1.2	-1.2	-0.9	-1.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.9	-0.6	-0.8	-0.9	-0.8	-0.8	-0.7	-1.0	0.3	-1.4	-1.1	-0.8	-1.1	-1.1
Osteoporosis (self-reported)	0.7	0.9	2.2	-0.8	-1.5	-1.1	-1.2	-1.0	-1.0	-0.9	-1.3	0.1	-0.6	-0.0	-0.7	-0.5
Fractured/broken bones in last 5 years	0.7	0.9	1.9	-1.0	-0.6	-1.2	-1.3	-1.4	-1.3	-0.6	-0.9	1.0	-0.3	1.0	-0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.6	-1.2	-1.4	-1.1	-0.9	-1.0	-1.1	-1.0	-1.5	-1.9	-1.7	-1.4	-1.2	-1.5
LDL Cholesterol	0.6	1.0	2.1	-1.1	-0.3	-1.4	-1.2	-1.4	-1.0	-0.8	-1.4	0.4	-0.2	0.7	-1.2	0.6
Rheumatoid Arthritis	0.6	0.9	2.6	-1.1	-1.6	-0.9	-1.4	-1.3	-1.0	-1.0	-0.6	0.5	-0.3	0.0	-0.7	-0.4
Schizophrenia (2014)	0.6	1.4	2.4	1.2	1.4	1.4	1.1	1.2	1.4	1.2	1.6	0.2	0.8	0.7	1.5	0.7
Allergy or Eczema	0.6	1.6	6.2	1.0	-0.2	0.7	-0.3	0.4	0.3	1.0	-0.0	2.0	1.9	2.0	0.7	2.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.8	-1.3	-0.7	-0.9	-0.9	-0.8	-0.7	-1.1	0.9	-1.4	-0.8	-2.0	-0.6	-1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	-0.8	-0.3	-1.0	-1.2	-1.3	-1.2	-0.9	0.3	-0.0	-0.2	-0.2	-1.0	-1.0
Sitting height	0.6	4.3	23.0	-1.4	-1.4	-2.1	-1.8	-1.6	-2.1	-1.6	-4.8	0.2	-1.7	1.4	-2.5	-0.5
Nervous feelings	0.6	1.2	2.5	-1.0	-1.1	-1.1	-0.9	-1.1	-1.3	-1.3	1.6	-1.2	-0.2	-1.1	-1.0	-0.3
Alcohol intake versus 10 years previously	0.6	0.9	3.9	-0.5	-0.6	-1.1	0.2	-0.4	-0.6	-0.8	-0.1	-0.9	-2.0	-0.7	-1.0	-1.7
Pulse rate	0.6	1.0	2.2	-1.1	-0.7	-1.0	-0.8	-1.0	-1.3	-1.0	0.3	-1.3	-1.0	-1.5	-1.0	-0.3
Medication: Amlodipine	0.6	0.8	2.2	0.9	1.2	0.5	1.5	0.9	1.2	0.4	0.7	-0.9	-0.7	-0.9	0.3	-0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.6	0.2	-0.4	0.2	-0.6	-0.2	-0.0	0.6	0.8	1.9	0.7	1.7	0.4	0.9
Comparative body size at age 10	0.6	1.8	3.9	-1.7	-1.4	-1.5	-1.6	-1.6	-1.6	-1.2	-2.0	-0.4	-1.0	0.4	-1.3	-0.6
Migraine (self-reported)	0.6	0.7	1.5	-1.0	-1.1	-0.6	-1.2	-1.1	-1.1	-0.7	1.0	0.6	0.5	0.6	-0.3	0.2
Had major operations	0.6	0.8	1.4	-0.4	-1.0	-1.2	-0.5	-0.9	-1.0	-0.8	0.9	-0.9	-1.1	-0.6	-1.2	-0.4
Medication: Aspirin	0.6	0.8	2.2	-0.8	-0.7	-0.7	-0.1	-0.5	-0.6	-0.8	1.4	-1.0	-0.9	-1.5	-0.8	-0.9
Medication: Blood pressure	0.6	1.1	4.0	1.0	1.3	0.6	2.0	1.3	1.3	0.4	1.2	-0.4	-0.5	-0.1	0.1	-1.1
Number of operations (self-reported)	0.6	0.9	2.5	-0.5	0.2	-0.7	-0.4	-0.6	-0.7	-0.5	-0.9	-1.4	-1.3	-1.1	-1.1	-1.6
Ever depressed for a whole week	0.6	0.7	1.7	0.8	-0.0	0.9	1.3	1.0	1.2	0.8	-1.1	0.5	-0.1	0.5	0.9	0.0
Heart disease (siblings)	0.6	0.7	2.1	1.0	1.0	0.6	0.6	0.6	0.6	1.1	0.9	1.4	0.7	0.9	0.8	0.6
Impedance of whole body	0.6	2.9	8.0	2.0	0.6	2.0	1.7	2.0	2.6	1.5	2.8	0.5	1.2	-0.3	2.0	0.2
Coronary Artery Disease (CAD)	0.5	0.5	2.9	0.5	0.1	0.4	0.0	0.2	0.3	0.4	-0.9	1.4	0.5	1.7	0.0	0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.9	0.4	-0.8	-0.1	-0.6	-0.5	-0.8	0.2	-1.2	1.2	1.4	0.7	-0.0	1.2
Trunk fat percentage	0.5	1.9	3.6	1.9	1.1	1.6	1.9	1.6	1.5	1.4	-0.4	1.1	0.5	1.2	1.8	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	3.1	-0.6	-0.4	-0.2	-0.0	-0.2	-0.2	-0.8	-0.8	-0.6	-1.1	-0.2	-0.5	-1.8
Had other major operations	0.5	0.6	2.2	-0.3	-0.8	-0.4	0.5	0.1	-0.1	-0.7	-0.0	-1.5	-0.9	-1.3	-0.5	-1.4
Time employed in main current job	0.5	0.6	2.0	0.8	0.8	1.0	0.6	0.6	0.9	0.7	-0.6	0.4	1.4	0.3	1.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.5	-0.5	-0.2	-0.6	-0.1	-0.3	-0.9	-0.7	-1.1	-1.1	-0.8	-1.3	-0.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.2	-0.6	-0.0	-0.6	-0.3	-0.5	-0.8	-1.0	-0.4	-1.5	-0.9	-0.5	-1.0	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	0.9	1.1	0.7	1.0	0.8	0.8	0.8	-0.2	0.5	0.9	0.2	0.8	0.8
Age at last live birth	0.5	0.8	1.2	1.1	0.9	0.7	1.0	1.0	0.8	0.9	0.5	0.5	1.1	1.0	0.6	1.0
Ever had bowel cancer screening	0.5	0.6	1.7	-0.8	-0.0	-0.6	-1.3	-0.8	-1.1	-0.5	-1.1	-0.1	-0.0	0.8	-0.8	-0.4
Commuting to job workplace: Walk	0.5	0.6	2.5	-0.5	-0.2	-0.7	-0.3	-0.6	-0.7	-0.6	1.0	-0.6	-1.6	-0.4	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.7	1.0	1.6	0.9	1.3	1.4	1.2	1.1	-1.5	-0.7	-0.7	0.1	0.4	-0.3
Supplements: Calcium	0.5	0.6	1.1	1.1	0.4	0.8	0.6	0.7	0.9	0.9	-0.2	0.5	0.3	0.9	0.9	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	-0.6	-0.0	-0.9	-0.2	-0.6	-0.7	-0.8	-0.4	-1.0	-1.3	-0.4	-1.2	-0.6
Neuroticism (2016)	0.4	0.5	1.6	0.6	-0.5	0.7	0.8	0.7	0.5	0.1	0.4	-0.9	0.1	-1.3	0.6	-1.1
Blood White Count	0.4	2.8	5.2	-1.7	-1.8	-2.0	-1.8	-1.9	-2.3	-1.8	-1.2	-1.1	-1.5	-0.9	-2.1	-0.5
Hypothyroidism (self reported)	0.4	0.9	3.8	1.1	0.6	0.8	1.9	1.5	1.3	0.5	-0.3	-0.8	0.2	-0.6	0.4	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	-0.7	-0.7	-0.8	-0.3	-0.6	-0.6	-0.7	1.2	-0.6	-1.1	-1.0	-0.6	-0.4
Leg fat-free mass (left)	0.4	1.9	20.0	-0.2	-0.1	-0.5	-0.2	-0.3	-1.0	-0.3	-4.5	0.4	-0.9	1.3	-0.6	-0.2
Maternal smoking around birth	0.4	0.6	1.9	-0.2	-1.0	-0.7	-0.8	-0.8	-0.9	-0.3	-0.5	0.9	0.2	1.4	-0.9	0.7
Taking other prescription medications	0.4	0.6	2.2	-0.3	-1.1	-0.6	0.1	-0.2	-0.2	-0.8	0.5	-0.9	-1.2	-1.5	-0.7	-0.9
Age when periods started (menarche)	0.4	0.9	2.4	-1.3	-0.9	-1.6	-0.9	-1.2	-1.0	-1.1	0.1	-0.3	-0.8	0.2	-1.2	0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.8	-0.4	-0.2	-0.7	-0.2	-0.4	-0.8	-0.8	-0.6	-1.3	-1.0	-0.7	-1.1	-0.7
Leg predicted mass (left)	0.4	1.9	20.3	-0.2	-0.0	-0.4	-0.2	-0.3	-1.0	-0.2	-4.5	0.6	-0.7	1.4	-0.5	-0.0
Waist circumference	0.4	1.3	4.3	1.3	1.3	1.3	2.1	1.4	1.2	1.0	0.3	0.2	-0.4	0.0	1.3	-1.2
Number of incorrect matches in round	0.4	0.7	2.6	0.4	-0.3	0.3	1.1	0.6	0.7	0.0	1.6	-0.6	-0.3	-1.4	0.3	-1.2
Heart attack	0.4	0.5	1.6	-0.6	-0.0	-0.8	-0.3	-0.6	-0.7	-0.8	-0.3	-1.0	-1.3	-0.4	-1.1	-0.5
Diabetes (self-reported)	0.4	0.6	2.9	-0.8	0.1	-0.5	-0.7	-0.6	-0.5	-0.4	1.5	-0.9	-0.0	-1.7	-0.1	0.1
Falls in the last year	0.4	0.5	1.5	0.7	0.7	0.8	1.2	1.0	1.1	0.6	0.0	-0.4	-0.2	-0.3	0.5	-0.7
Birth weight of first child	0.4	0.6	2.6	0.1	-0.0	-0.7	-0.9	-0.7	-1.1	-0.2	-0.9	0.0	-0.5	1.6	-1.2	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.9	0.0	-0.5	-0.0	0.9	0.5	0.4	-0.4	-0.6	-1.7	-0.8	-1.7	-0.3	-1.7
Emphysema/chronic bronchitis	0.4	0.5	1.1	0.8	0.7	0.8	0.6	0.7	0.9	0.7	0.3	0.1	1.1	-0.1	0.8	0.8
Pulse rate, automated reading	0.4	1.4	3.3	1.1	0.8	1.3	0.7	0.9	0.6	1.4	-0.4	1.7	1.1	1.2	1.5	1.8
Medication: Aspirin	0.4	0.5	2.5	-0.6	-0.7	-0.5	-0.1	-0.4	-0.5	-0.5	1.6	-0.4	-0.5	-0.9	-0.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.8	0.3	-0.2	0.4	0.7	0.5	0.3	0.3	-1.7	-0.7	-0.4	-1.0	0.0	-0.7
Leg fat-free mass (right)	0.4	2.0	18.7	-0.5	-0.3	-0.8	-0.5	-0.7	-1.4	-0.7	-4.3	0.3	-1.1	1.2	-1.0	-0.3
Average weekly red wine intake	0.4	0.6	2.8	-0.4	-0.7	-0.4	0.1	-0.2	0.0	-0.5	0.2	-1.4	-1.4	-1.7	-0.2	-0.1
Medication for cholesterol	0.4	0.6	2.1	-0.8	-0.9	-0.4	-0.9	-0.6	-0.7	-0.5	-1.5	-0.9	-0.8	-0.4	-0.3	-0.8
Back pain experienced in last month	0.4	0.5	5.0	-0.6	0.4	-0.2	-0.3	-0.3	-0.5	-0.3	2.2	-0.4	0.2	-0.8	-0.1	-0.3
Leg predicted mass (right)	0.4	2.1	19.2	-0.5	-0.3	-0.8	-0.6	-0.7	-1.4	-0.6	-4.4	0.4	-1.0	1.2	-1.0	-0.2
Number of self-reported non-cancer illnesses	0.4	0.7	2.1	0.8	0.7	0.7	1.2	0.9	1.1	0.5	1.5	0.5	0.3	-0.6	0.7	0.2
Average weekly champagne plus white wine intake	0.4	0.6	1.8	0.4	0.5	0.9	0.7	0.7	1.3	0.8	0.7	0.7	0.8	0.1	1.2	0.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.8	-0.2	-0.6	-0.1	-0.2	-0.4	-0.2	0.1	1.4	0.5	0.9	-1.1	0.5	1.3
Medication: Atorvastatin	0.4	0.5	1.1	-0.9	-0.2	-1.0	-0.8	-1.1	-0.9	-0.7	-0.1	0.2	-0.4	-0.3	-0.9	0.1
Alcohol drinker status: Never	0.4	0.5	4.4	0.3	0.6	0.3	0.6	0.5	0.4	-0.0	0.7	-0.3	-0.6	-0.5	0.1	-2.1
Bipolar Disorder or Schizophrenia	0.3	0.6	4.9	-0.1	0.0	0.2	0.1	0.0	0.5	-0.2	2.2	-1.1	-0.0	-1.1	0.3	-0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.8	0.7	0.9	0.3	0.5	0.5	0.3	0.7	0.8	-0.8	-0.2	-0.5	0.1	0.1
Ulcerative Colitis (UC)	0.3	0.6	3.5	-0.1	-1.1	-0.6	-0.4	-0.5	-0.5	-0.1	-1.9	1.0	0.7	0.9	-0.2	-0.1
Major Depression (MDD)	0.3	0.3	1.5	0.5	0.6	0.5	0.6	0.6	0.6	0.5	0.4	0.3	0.5	0.4	0.3	1.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.7	-0.1	-0.5	-0.1	0.0	0.1	-0.1	-0.1	-1.7	0.4	-0.1	0.2	-0.3	-0.7
Blood Eosinophil Count	0.3	2.0	4.7	-1.0	-2.2	-1.4	-0.8	-1.1	-1.4	-1.8	-1.3	-1.6	-0.7	-1.5	-1.9	-0.7
BMI	0.3	1.8	5.7	-1.0	-0.3	-1.2	-0.4	-1.0	-1.4	-1.2	-2.4	-0.5	-2.1	-0.0	-1.5	-1.9
Chronotype (morning person)	0.3	0.7	1.2	1.1	1.0	0.9	0.8	1.1	0.7	1.1	-0.7	0.6	0.4	0.7	0.9	0.4
Average weekly spirits intake	0.3	0.3	1.1	-0.1	0.1	-0.4	-0.0	-0.3	-0.1	-0.6	1.0	-1.0	-0.6	-0.9	-0.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.7	-0.2	-0.9	-0.8	-0.8	-0.9	-0.5	-0.6	0.4	-0.4	0.4	-0.7	-0.3
Vitamin and mineral supplements	0.3	0.5	1.6	0.4	0.1	0.6	0.1	0.5	0.6	0.5	-1.3	0.9	1.1	0.4	0.6	0.6
Diabetes (mother)	0.3	0.4	1.1	-0.3	-0.0	-0.6	-1.0	-1.1	-0.7	-0.3	-0.9	0.4	0.3	-0.1	-0.6	0.4
Pack years adult smoking proportion	0.3	0.5	1.8	-0.1	-0.6	-0.2	-0.7	-0.6	-1.0	-0.2	-0.3	0.7	1.4	0.4	-0.2	1.0
Fed-up feelings	0.3	0.6	2.5	-0.5	-0.9	-0.2	0.4	-0.1	-0.0	-0.6	0.2	-1.2	-1.1	-1.6	-0.1	-1.1
Relative age voice broke	0.3	0.4	1.3	-0.7	-0.6	-0.8	-0.5	-0.7	-0.5	-0.7	-1.1	-0.0	-0.4	-0.0	-0.9	-0.2
Multivitamins +/- minerals	0.3	0.3	1.2	-0.3	-0.0	-0.4	-0.1	-0.4	-0.4	-0.4	0.1	-0.8	-1.0	-0.6	-0.5	-1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.9	0.3	0.4	0.3	1.0	0.6	0.8	-0.0	0.2	-0.9	-0.0	-1.4	0.3	-0.1
Forced vital capacity (FVC)	0.3	1.2	5.6	0.1	0.5	-0.0	0.9	0.8	0.3	-0.0	-2.4	-1.2	-2.3	-0.2	-0.6	-1.2
Arm fat percentage (right)	0.3	1.1	2.5	1.4	1.2	1.2	1.6	1.1	1.0	1.0	-0.3	0.7	0.2	0.8	1.3	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.3	-1.1	-0.8	-0.6	-1.2	-0.7	-0.6	-0.6	-1.5	0.0	-1.1	-0.4	-0.5	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	6.0	0.4	0.8	0.1	0.3	0.1	0.1	0.2	2.5	0.2	0.1	-0.1	-0.0	-0.0
Asthma	0.3	0.5	1.3	-0.5	-1.1	-0.6	-0.8	-0.8	-0.5	-0.7	0.0	-0.7	-0.5	-1.2	-0.7	-0.5
Medication: Lansoprazole	0.3	0.3	1.0	0.6	1.0	0.3	0.8	0.5	0.5	0.1	-0.6	-0.3	-0.4	-0.1	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	5.6	0.3	0.6	0.2	0.9	0.9	0.5	0.5	-2.4	-0.3	-1.5	0.6	-0.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	3.1	0.1	-0.3	-0.0	0.4	0.1	0.1	0.1	1.8	1.0	0.2	0.7	0.0	0.6
Forced vital capacity (FVC), Best measure	0.3	1.2	8.4	0.3	0.3	0.2	1.0	0.9	0.5	0.3	-2.9	-0.5	-1.8	0.5	-0.2	-0.9
Body fat percentage	0.3	1.1	2.5	1.5	0.8	1.3	1.6	1.2	1.1	1.0	0.1	0.8	0.2	0.8	1.4	-0.7
Arm fat-free mass (right)	0.3	1.5	6.4	-1.0	-0.6	-1.2	-0.7	-0.8	-1.6	-1.0	-2.5	-0.3	-1.7	0.2	-1.3	-0.7
Number of full brothers	0.3	0.4	2.2	-0.2	0.7	-0.3	-0.1	-0.4	-0.3	0.1	1.5	1.0	0.4	0.4	-0.1	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	2.2	0.2	-0.6	0.2	1.0	0.6	0.6	0.3	1.5	-0.3	-0.6	-0.6	0.5	0.4
Medication: Allopurinol	0.3	0.4	1.5	0.2	1.0	0.7	-0.0	0.2	0.4	0.5	0.1	0.9	1.2	0.4	0.8	0.4
Medication: Omeprazole	0.3	0.4	1.0	-0.4	-0.4	-0.8	-0.2	-0.5	-0.7	-0.7	0.1	-0.8	-0.3	-0.9	-1.0	-0.5
Overall health rating	0.3	0.6	1.4	0.7	1.2	0.7	0.9	0.6	0.4	0.7	-1.1	0.5	0.6	0.4	0.7	-0.7
Supplements: Vitamin C	0.3	0.4	2.6	0.5	0.5	0.1	0.9	0.5	0.3	0.2	1.6	-0.5	-0.7	0.2	-0.0	0.0
Whole body fat-free mass	0.3	1.6	11.6	-0.8	-0.4	-1.1	-0.6	-0.7	-1.5	-0.8	-3.4	-0.1	-1.4	0.6	-1.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.5	0.3	-0.6	-0.2	-0.6	-0.4	-0.8	-0.5	-0.9	-0.9	-0.3	-0.7	-0.2
Friendships satisfaction	0.3	0.4	1.5	-0.1	-0.6	-0.3	0.2	-0.0	-0.1	-0.4	-1.1	-1.0	-0.8	-0.5	-0.4	-1.2
Whole body water mass	0.3	1.5	11.7	-0.7	-0.3	-1.0	-0.5	-0.6	-1.4	-0.7	-3.4	-0.0	-1.4	0.7	-1.1	-0.5
Wears glasses or contact lenses	0.3	0.4	1.1	-0.4	-0.1	-0.6	-0.6	-0.5	-0.6	-0.1	0.8	0.5	-1.1	0.9	-0.7	-0.2
Medication: Paracetamol	0.3	0.5	1.2	1.0	0.7	0.8	0.7	0.7	0.6	0.7	-0.4	0.6	0.5	1.1	0.7	0.4
Medication: Lisinopril	0.3	0.4	1.5	0.1	-0.0	-0.0	0.7	0.4	0.3	-0.4	0.5	-1.2	-0.7	-1.2	-0.1	-0.5
Unable to work because of sickness or disability	0.3	0.3	1.0	-0.2	-0.6	-0.8	0.1	-0.4	-0.3	-0.4	1.0	0.9	-0.9	0.4	-0.5	-0.3
Cholesterol lowering medication	0.3	0.5	1.1	0.7	0.8	0.6	0.6	0.5	0.6	0.7	0.9	0.5	0.9	0.1	0.7	1.1
Pack years of smoking	0.3	0.5	2.4	0.1	-0.3	-0.1	-0.6	-0.5	-0.8	0.1	-0.5	0.9	1.5	0.7	0.0	1.2
Age at First Birth	0.2	0.3	1.4	0.1	0.3	0.2	-0.4	-0.0	-0.2	0.4	-0.9	0.5	1.1	0.5	-0.1	1.2
Mean Putamen Volume	0.2	0.3	1.4	-0.5	-0.1	-0.0	-0.7	-0.4	-0.2	-0.3	0.4	-0.9	0.1	-1.2	-0.0	-0.3
Height	0.2	3.6	15.1	1.8	1.4	0.9	1.1	1.9	0.7	1.6	-2.7	2.1	0.6	3.9	0.5	2.4
Respiratory disease	0.2	0.4	1.1	0.4	-0.3	0.5	-0.1	0.2	0.2	0.5	-0.9	0.9	0.8	0.2	0.8	1.0
Neuroticism	0.2	0.4	1.5	0.5	0.3	0.5	1.2	0.8	0.8	0.2	0.5	-0.5	-0.7	-0.6	0.3	-0.9
Medication: Metformin	0.2	0.3	2.2	-0.9	-0.4	-0.3	-0.5	-0.4	-0.2	-0.4	0.5	-0.4	-0.0	-1.5	0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	3.7	-0.0	-0.1	0.1	-0.0	0.1	0.1	0.5	1.9	0.1	-0.1	0.4	0.1	0.6
Medication: Levothyroxine sodium	0.2	0.4	1.3	0.4	0.1	0.4	1.1	0.7	0.7	0.2	-0.6	-0.4	-0.1	-0.8	0.3	-0.9
Trunk fat mass	0.2	0.9	1.7	1.2	0.6	1.0	1.3	1.0	0.7	0.8	-1.1	0.8	-0.2	1.1	1.0	-0.8
Financial difficulties in last 2 years	0.2	0.2	0.9	0.1	0.4	-0.1	0.2	-0.0	-0.4	-0.3	-1.0	-0.6	-0.4	-0.0	-0.5	-0.9
Pain all over the body in last month	0.2	0.2	1.2	0.3	1.1	0.3	0.1	0.2	0.3	0.4	0.4	-0.2	-0.2	-0.4	0.2	-0.6
Fluid intelligence score	0.2	0.5	2.1	-0.0	-0.4	0.2	-0.2	0.1	0.1	0.0	-1.4	-1.2	-0.6	-1.2	0.2	-0.9
Trunk fat-free mass	0.2	1.3	7.6	-0.8	-0.3	-1.1	-0.6	-0.5	-1.4	-0.8	-2.8	-0.3	-1.5	0.4	-1.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.8	0.5	1.3	0.5	1.1	1.1	0.6	0.7	-1.7	-0.2	-1.4	0.7	-0.1	-0.1
Depression (self-reported)	0.2	0.2	0.4	-0.3	-0.5	-0.6	-0.2	-0.4	-0.5	-0.3	-0.3	-0.0	-0.6	0.4	-0.7	0.4
Lung cancer (father)	0.2	0.2	1.0	-0.1	-0.3	0.1	0.1	-0.0	0.4	0.1	1.0	0.7	0.0	0.7	0.3	0.5
Illnesses of mother	0.2	0.3	0.8	-0.6	-0.3	-0.4	-0.9	-0.7	-0.6	-0.2	-0.0	0.2	-0.2	0.8	-0.1	0.7
Trunk predicted mass	0.2	1.1	7.0	-0.7	-0.2	-1.0	-0.4	-0.4	-1.3	-0.6	-2.6	-0.2	-1.5	0.4	-1.1	-0.5
Tense / ‘highly strung’	0.2	0.3	1.2	0.2	-0.3	0.0	0.8	0.2	0.3	-0.6	0.5	-0.8	-0.6	-1.1	0.0	-0.7
Peak expiratory flow (PEF)	0.2	0.6	2.1	-0.3	0.9	-0.5	-0.5	-0.2	-0.7	0.1	-0.9	0.7	-0.3	1.4	-0.9	1.1
Gout (self-reported)	0.2	0.2	1.1	-0.1	0.5	0.6	0.0	0.3	0.3	0.5	-0.0	0.2	0.4	-0.6	1.1	0.2
Age at first live birth	0.2	0.4	1.6	0.4	0.5	0.2	0.8	0.7	0.7	0.3	0.9	-1.2	-0.6	-0.5	-0.1	-0.7
Shortness of breath walking on level ground	0.2	0.3	0.8	-0.2	-0.2	-0.7	-0.1	-0.4	-0.5	-0.8	-0.3	-0.9	0.1	-0.4	-0.8	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	1.1	-0.2	0.3	0.0	-0.7	-0.2	-0.2	0.3	-0.6	1.0	0.6	1.0	0.2	0.7
Medication: Seretide 50 evohaler	0.2	0.3	1.3	-0.3	-1.0	-0.2	-0.0	-0.3	-0.2	-0.4	0.8	-0.6	0.0	-1.1	0.0	-0.2
Whole body fat mass	0.2	0.6	1.6	1.0	0.5	0.8	1.3	0.9	0.6	0.6	-1.0	0.5	-0.3	0.7	0.9	-0.7
Arm predicted mass (right)	0.2	1.2	6.8	-0.8	-0.4	-1.1	-0.6	-0.7	-1.4	-0.8	-2.6	-0.2	-1.4	0.3	-1.1	-0.4
Comparative height size at age 10	0.2	1.3	2.6	1.5	1.4	1.0	1.4	1.5	1.0	1.2	-1.1	0.8	-0.0	1.6	0.6	0.7
Leg pain on walking	0.2	0.3	2.8	0.1	0.3	0.1	0.2	0.2	-0.0	-0.0	-1.7	-0.3	0.4	-0.3	-0.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.6	0.5	0.5	0.1	0.2	0.2	-0.3	0.4	-0.4	0.1	0.6	0.9	-0.2	1.3
Knee pain experienced in last month	0.2	0.3	1.1	-0.3	0.2	-0.1	-0.3	-0.6	-0.6	-0.1	-1.0	0.6	-0.5	0.8	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	3.9	-0.1	-0.2	-0.2	-0.2	-0.0	-0.6	-0.0	-2.0	-0.2	-0.0	0.5	-0.2	0.8
Arm fat percentage (left)	0.2	0.8	1.8	1.1	0.9	1.0	1.3	0.9	0.8	0.8	-0.7	0.7	0.1	0.9	1.1	-0.7
Diabetes diagnosed by doctor	0.2	0.4	2.1	-0.6	-0.3	-0.1	-0.5	-0.3	-0.2	-0.3	1.1	-0.5	0.4	-1.4	0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	2.1	-0.4	0.1	-0.4	-0.3	-0.3	-0.5	-0.3	1.5	0.3	-0.2	0.3	-0.5	0.6
Medication: Gliclazide	0.2	0.3	1.5	-0.1	0.9	0.1	-0.2	0.2	-0.1	0.1	-1.2	-0.3	0.4	0.1	-0.3	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.3	1.1	-0.2	-0.7	-0.2	-0.2	-0.0	-0.3	0.1	0.3	0.8	0.2	1.0	0.0	1.0
Guilty feelings	0.2	0.3	0.5	-0.4	-0.7	-0.4	-0.3	-0.4	-0.7	-0.6	-0.6	-0.4	-0.2	-0.3	-0.5	-0.7
Commuting to job workplace: Public transport	0.2	0.3	1.4	0.1	-0.1	-0.1	0.5	0.1	0.4	-0.1	0.5	-0.7	-0.8	-0.4	-0.0	-1.2
Basal metabolic rate	0.2	1.2	9.6	-0.5	-0.2	-0.8	-0.2	-0.4	-1.2	-0.5	-3.1	0.1	-1.3	0.7	-0.8	-0.5
Arm fat-free mass (left)	0.2	0.9	4.6	-0.7	-0.2	-0.9	-0.5	-0.5	-1.3	-0.6	-2.1	-0.2	-1.4	0.3	-0.9	-0.6
Arm predicted mass (left)	0.2	0.8	3.4	-0.6	-0.2	-0.8	-0.2	-0.4	-1.2	-0.6	-1.9	-0.4	-1.6	0.1	-0.9	-0.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	-0.4	-0.8	-0.3	0.4	-0.1	-0.0	-0.5	0.2	-0.5	-0.9	-0.8	-0.3	-0.3
Depression (Nagel 2018)	0.1	0.1	1.0	-0.2	-0.2	-0.4	0.0	-0.3	-0.4	-0.2	1.0	0.1	-0.3	-0.1	-0.3	0.5
Neuroticism (Nagel 2018)	0.1	0.3	1.2	0.5	-0.1	0.5	1.1	0.6	0.7	0.2	0.3	-0.3	-0.3	-0.5	0.5	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.4	1.2	-0.3	-0.5	-0.1	-0.1	-0.1	0.1	-0.1	-0.4	-1.1	-0.9	-1.1	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	-0.1	-0.7	0.1	0.4	0.2	0.1	-0.3	-0.2	-0.7	-0.7	-0.4	0.1	-0.4
HDL Cholesterol	0.1	0.1	0.4	0.2	0.1	-0.3	-0.0	-0.0	-0.1	-0.2	0.6	0.1	-0.6	0.4	-0.5	-0.6
Lupus	0.1	0.2	0.9	-0.2	-0.1	-0.5	-0.5	-0.6	-0.2	-0.5	-0.0	-0.3	0.4	-1.0	-0.3	-0.1
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.3	0.5	-0.4	-0.5	-0.4	-0.6	-0.3	0.6	-0.3	-0.3	0.2	-0.7	-0.2
Heel T-Score	0.1	0.6	6.7	-0.4	-0.0	0.0	-0.5	-0.1	-0.1	0.1	2.6	-0.6	0.2	-0.7	-0.3	0.3
Hair Pigment	0.1	2.0	22.5	0.3	1.0	0.1	-0.1	-0.0	-0.1	0.3	4.7	-0.0	0.8	-0.6	-0.0	1.0
Tanning	0.1	0.9	4.0	0.4	-0.2	0.8	1.0	0.8	1.3	0.4	-2.0	-0.3	0.4	-1.0	0.7	-0.9
Number of treatments/medications taken	0.1	0.2	0.8	0.5	0.0	-0.0	0.6	0.2	0.1	-0.0	0.9	-0.2	-0.2	-0.7	-0.0	-0.5
Townsend deprivation index at recruitment	0.1	0.2	1.3	0.5	0.2	0.1	0.3	0.0	-0.0	0.0	0.3	0.7	0.5	1.1	-0.1	-0.0
Medication: Atenolol	0.1	0.1	0.3	-0.1	-0.5	-0.0	0.2	-0.0	0.0	-0.3	-0.4	-0.1	0.0	-0.6	0.1	0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.7	0.4	0.8	0.0	0.1	-0.1	-0.0	0.1	0.8	0.3	0.4	0.3	-0.1	-0.0
Body mass index (BMI)	0.1	0.3	1.3	-0.0	0.3	-0.1	0.2	-0.3	-0.5	-0.1	-1.0	0.0	-0.6	0.4	-0.0	-1.1
Past tobacco smoking	0.1	0.2	0.4	-0.4	-0.7	-0.2	-0.2	-0.3	-0.6	-0.2	0.1	-0.0	-0.3	-0.6	-0.4	-0.6
Weight	0.1	0.6	4.1	0.5	0.5	0.2	0.7	0.4	-0.1	0.3	-2.0	0.5	-0.8	1.1	0.2	-0.8
Hip circumference	0.1	0.4	1.5	0.0	0.3	-0.3	0.2	-0.1	-0.7	-0.1	-0.7	0.5	-1.1	0.9	-0.2	-1.2
Father’s age at death	0.1	0.2	0.5	0.1	0.5	0.0	0.0	0.3	0.2	0.5	-0.7	0.2	-0.4	0.7	-0.1	0.5
Noisy workplace	0.1	0.1	0.9	0.2	0.3	0.1	0.0	-0.1	-0.0	0.1	1.0	0.5	0.2	0.5	-0.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.3	0.1	-0.5	-0.4	-0.3	-0.4	-0.5	0.5	-0.1	-0.1	-0.2	-0.6	-0.2
Prospective memory result	0.1	0.1	0.9	0.1	0.6	-0.1	0.1	-0.1	-0.1	0.0	0.9	0.1	0.6	-0.2	0.1	0.1
Arm fat mass (right)	0.1	0.4	1.5	0.6	0.4	0.4	0.9	0.5	0.1	0.3	-1.2	0.2	-0.6	0.4	0.5	-1.1
Standing height	0.1	1.0	6.7	0.9	0.1	0.4	0.8	1.2	0.5	0.6	-2.6	0.6	-0.8	1.3	0.2	0.3
Breastfed as a baby	0.1	0.1	0.8	0.1	0.9	-0.1	0.1	0.0	0.1	0.1	0.0	0.2	-0.1	0.8	-0.4	-0.2
Headache pain in last month	0.1	0.2	1.2	-0.4	-1.1	-0.3	-0.2	-0.1	-0.5	-0.5	0.6	-0.6	-0.4	-0.2	-0.3	-0.2
Leg fat percentage (right)	0.1	0.5	1.3	0.6	0.2	0.6	1.1	0.6	0.7	0.4	1.1	-0.3	-0.3	-0.4	0.9	-1.0
Qualifications: College or University degree	0.1	0.2	1.2	-0.7	0.3	-0.3	-0.4	-0.2	0.1	0.0	0.6	-0.2	-1.1	-0.5	-0.1	0.3
Leg fat mass (right)	0.1	0.3	1.6	0.0	-0.3	-0.0	0.5	0.0	-0.2	-0.3	-0.6	-0.5	-0.9	-0.3	0.2	-1.3
Suffer from ‘nerves’	0.1	0.2	1.1	-0.1	-0.9	-0.2	-0.1	-0.3	-0.3	-0.5	1.0	0.0	0.5	-0.3	0.1	0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.5	0.2	0.7	0.2	0.3	0.5	0.4	0.4	-0.5	0.1	0.5	0.1	0.1	0.6
Illnesses of father: Heart disease	0.1	0.1	0.6	0.1	0.4	0.2	0.1	0.1	0.1	0.1	-0.8	-0.3	0.0	-0.6	-0.0	-0.6
Arm fat mass (left)	0.1	0.5	1.7	0.7	0.5	0.5	1.0	0.6	0.2	0.4	-1.3	0.4	-0.4	0.6	0.6	-0.8
Miserableness	0.1	0.2	1.0	-0.1	-0.3	0.0	0.6	0.1	0.1	-0.3	0.9	-0.4	-1.0	-0.7	-0.1	-0.4
Ever smoked	0.1	0.2	1.0	0.3	0.2	0.2	0.4	0.3	0.7	0.2	0.4	0.3	0.6	0.4	0.4	1.0
Leg fat percentage (left)	0.1	0.4	1.8	0.3	-0.0	0.3	0.8	0.3	0.3	-0.0	1.3	-0.6	-0.7	-0.6	0.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.2	0.2	0.1	0.5	0.2	0.2	-0.0	-0.0	-0.1	0.4	-0.3	-0.1	-0.5
Pain experienced in last month	0.1	0.2	1.8	0.3	-0.1	0.1	-0.1	0.1	0.2	0.1	-1.3	0.1	0.2	0.6	-0.0	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.4	0.2	0.6	0.1	0.2	0.2	0.2	0.2	-0.7	0.2	-0.4	0.3	-0.1	-0.0
Leg fat mass (left)	0.1	0.3	1.9	-0.0	-0.4	-0.0	0.4	-0.0	-0.3	-0.4	-0.5	-0.5	-0.9	-0.3	0.1	-1.4
Worry (Nagel 2018)	0.0	0.1	0.4	0.2	-0.2	-0.0	0.2	-0.1	-0.0	-0.3	0.7	-0.1	0.2	-0.1	0.1	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.3	0.3	-0.0	-0.0	0.1	-0.1	-0.3	0.0	0.5	0.0	0.1	0.1	-0.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.3	0.2	-0.3	-0.1	-0.2	-0.2	-0.2	-0.1	0.5	0.3	-0.0	0.2	-0.1	-0.2
Asthma (self-reported)	0.0	0.1	0.3	0.0	-0.6	-0.2	-0.4	-0.3	-0.0	-0.2	0.0	-0.1	-0.1	-0.4	-0.3	-0.1

Hub : Genes

TENC1

Models

Trait associations