Hub : Genes

TFG

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0867	0.0289	1.8e-04	0.072	NA	0.070	NA	0.068	1.4e-07	NA	2.1e-07	NA	3.0e-07
2	GTEx	Spleen	0.3270	0.1220	9.7e-03	-0.011	NA	0.025	NA	-0.007	9.0e-01	NA	7.4e-02	NA	5.1e-01
3	GTEx	Whole Blood	0.0640	0.0240	5.0e-04	0.059	NA	0.033	NA	0.042	4.0e-06	NA	4.7e-04	NA	8.9e-05
4	YFS	Blood	0.1329	0.0231	0.0e+00	0.193	0.210	0.211	0.208	0.204	7.0e-61	8.6e-67	4.4e-67	5.2e-66	1.3e-64
5	TCGA	Lung Adenocarcinoma	0.0426	0.0219	2.8e-05	0.013	0.027	0.019	NA	0.021	8.9e-03	3.9e-04	2.3e-03	NA	1.5e-03
6	TCGA	Prostate Adenocarcinoma	0.0383	0.0223	2.5e-04	0.017	0.027	0.028	NA	0.013	5.5e-03	7.1e-04	5.2e-04	NA	1.4e-02
7	TCGA	Thyroid Carcinoma	0.0800	0.0360	5.3e-09	0.091	0.097	0.067	NA	0.090	3.4e-09	1.1e-09	4.3e-07	NA	4.3e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.2	0.7	-0.1	-0.9	-0.1	-0.5	0.2	-0.1	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.1	0.3	-0.5	-1.2	-1.5	1.1	0.8	1.1
Depressed Affect (Nagel 2018)	0.9	1.9	3.3	0.5	1.8	-1.3	-1.7	1.4	1.2	1.1
Depression (Nagel 2018)	1.7	2.6	4.0	1.5	0.5	-1.2	-1.9	2.0	1.6	1.9
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.5	0.6	-1.9	1.4	1.5	-0.1	-0.3	0.3
Neuroticism (Nagel 2018)	0.9	2.0	2.9	1.2	1.3	-1.5	-1.5	1.4	1.7	1.3
Schizophrenia (2018)	0.5	1.1	2.2	0.4	-0.1	-1.4	-1.5	1.2	1.1	0.8
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	0.0	0.2	0.0	0.6	0.1	-0.3	-0.7
Worry (Nagel 2018)	0.4	0.8	2.6	0.2	1.6	-0.6	-0.3	0.8	1.4	0.2
Alzheimer’s Disease (in mother)	0.9	1.0	1.9	1.1	-1.4	-0.1	-0.5	0.8	1.1	1.3
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.1	0.9	-0.5	-0.9	0.5	0.8	0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	1.9	1.0	-0.5	-1.2	-1.4	1.0	1.0	1.1
Crohns Disease (2017)	0.7	1.5	3.1	1.0	-0.4	-1.1	-1.3	1.8	1.2	1.4
Irritable Bowel Disease (IBD)	0.4	1.1	2.3	1.0	-1.1	0.0	-0.3	1.5	1.1	1.2
Ulcerative Colitis (UC)	0.6	1.1	2.1	1.1	-1.2	0.4	0.0	1.2	1.5	1.2
Major Depression (MDD)	0.9	1.1	2.3	1.5	0.5	-0.7	-0.6	1.5	1.0	1.0
Reaction Time	1.3	2.5	8.0	1.4	2.8	-0.3	-0.4	1.9	1.3	1.5
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.9	0.3	-1.1	1.7	1.7	-0.1	-0.6	0.0
Breast Cancer	1.1	2.7	5.6	-2.4	-0.5	0.3	-0.1	-2.0	-1.9	-2.2
Ovarian Cancer	0.8	1.1	2.1	-1.0	-1.2	0.2	0.1	-1.4	-1.3	-1.2
Prostate Cancer	0.2	0.3	0.7	0.3	0.7	0.7	0.5	-0.9	-0.2	-0.0
Age at First Birth	1.3	1.9	3.0	-0.8	1.6	1.6	1.7	-1.2	-0.8	-1.6
Bipolar Disorder (2011)	0.2	0.2	0.9	0.1	-1.0	0.6	0.2	0.1	-0.2	0.4
Body Mass Index (BMI) (2010)	0.7	1.0	5.3	-0.8	2.3	-0.6	-0.4	0.7	-0.2	-0.4
Coronary Artery Disease (CAD)	0.9	1.0	2.6	0.8	1.6	0.7	0.9	1.1	1.0	0.6
Crohns Disease (2012)	0.6	1.0	2.2	1.3	0.0	0.9	-0.2	1.5	0.7	1.4
Mean Putamen Volume	0.3	0.3	0.8	-0.0	-0.4	0.8	0.9	-0.2	-0.9	-0.3
Fasting Glucose	1.7	2.1	5.3	-0.4	0.2	2.3	2.2	-1.0	-1.2	-1.3
HbA1C	0.2	0.3	0.8	-0.1	0.6	-0.3	-0.3	-0.4	-0.9	-0.6
HDL Cholesterol	0.2	0.3	1.3	0.1	-0.1	1.1	0.8	0.0	0.6	0.1
LDL Cholesterol	0.8	1.2	3.6	0.2	-0.6	1.4	1.3	-1.9	-0.7	-0.7
Lupus	1.5	2.3	7.1	0.5	-2.7	2.1	1.6	-1.0	0.2	0.4
Neuroticism (2016)	0.8	1.2	2.0	1.0	1.4	-0.4	-0.6	1.2	1.1	1.4
Primary Biliary Cirrhosis	0.8	1.2	3.6	1.3	0.4	1.9	1.2	0.3	1.0	0.5
Rheumatoid Arthritis	0.7	1.0	3.0	1.7	-0.5	-0.4	-0.1	0.7	1.1	1.3
Schizophrenia (2014)	0.5	1.1	2.0	0.8	-0.5	-1.4	-1.3	1.2	1.0	1.0
Triglycerides	1.3	2.1	3.5	1.5	0.1	-1.4	-1.2	1.8	1.5	1.9
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.4	-1.4	-0.3	0.9	1.2	-1.2	-1.8	-1.7
Ulcerative Colitis	0.6	0.9	1.9	0.8	-1.4	1.0	0.6	0.9	0.7	0.8
Blood Eosinophil Count	0.2	1.3	3.7	-0.5	-1.9	-0.3	-0.8	-1.4	-1.4	-0.7
Blood Platelet Count	0.1	1.1	3.6	0.4	0.9	-1.9	-1.1	1.3	0.1	0.8
Blood Red Count	0.1	1.1	2.8	0.6	-1.7	-1.4	-1.6	-0.0	0.4	0.4
Blood White Count	0.3	2.6	6.2	2.5	1.1	-1.6	-1.6	1.2	1.3	1.4
Heel T-Score	1.3	10.0	17.1	-3.0	3.0	2.6	2.9	-3.0	-3.3	-4.1
BMI	0.3	1.7	5.0	-2.1	-0.2	0.1	-0.3	-0.4	-2.2	-1.4
Height	0.4	7.4	18.2	3.4	0.2	0.0	-0.2	2.4	4.3	4.0
Waist Hip Ratio (WHR)	3.6	16.4	32.3	5.7	1.5	-2.5	-2.7	4.1	5.1	4.9
Systolic Blood Pressure	0.4	1.9	3.8	-1.9	-1.6	-1.9	-1.6	-0.2	-0.1	-0.7
Smoking Status	0.7	1.7	3.3	1.6	0.5	-1.8	-1.7	1.0	0.7	1.1
Allergy or Eczema	0.1	0.3	1.3	-0.1	-0.0	-0.6	-1.1	0.1	0.2	0.3
Cardiovascular Disease	0.6	1.8	3.9	-1.4	-1.0	0.4	0.5	-2.0	-1.7	-1.6
Hypothyroidism (self reported)	0.3	0.8	2.2	0.1	-0.6	-0.9	-1.5	0.2	0.7	1.2
Respiratory disease	0.4	0.8	2.6	0.6	-0.7	-0.6	-0.8	1.6	0.8	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.2	0.4	-0.3	-0.5	-1.1	-0.0	-0.4	0.4
Lung FEV1/FVC ratio	0.4	2.0	4.3	1.1	1.6	-0.8	-0.6	1.3	2.1	1.9
Lung FVC	3.7	18.7	30.3	-5.5	1.0	3.5	3.1	-4.5	-5.3	-5.4
Neuroticism	0.6	1.5	2.5	1.0	1.3	-1.4	-1.2	1.0	1.6	1.1
Chronotype (morning person)	0.6	1.5	2.9	-0.7	-1.7	1.1	1.4	-1.3	-1.1	-0.9
Hair Pigment	0.0	0.8	1.7	0.8	-1.3	0.1	-0.9	0.8	0.4	1.1
Tanning	0.1	1.1	2.8	-1.6	-0.1	0.1	0.8	-0.9	-1.0	-1.7
Hand grip strength (left)	0.8	2.0	4.2	1.5	-1.9	0.6	0.3	0.3	1.9	2.1
Number of treatments/medications taken	0.6	1.1	2.6	0.5	-0.5	-0.4	-0.8	1.3	1.6	1.5
Average weekly spirits intake	0.9	1.1	2.6	0.7	0.8	-0.5	-0.5	1.6	1.3	1.2
Sensitivity / hurt feelings	0.3	0.5	1.0	-0.8	0.1	0.5	-0.0	-0.6	-1.0	-1.0
Frequency of depressed mood in last 2 weeks	4.0	5.6	8.5	2.4	0.4	-1.9	-2.4	2.9	2.5	2.9
Hearing difficulty/problems: Yes	1.7	2.6	4.1	-1.7	-1.3	1.1	1.1	-1.9	-1.9	-2.0
Relative age of first facial hair	0.6	1.2	3.0	-0.5	-0.9	1.1	1.7	-1.4	-0.8	-0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.8	1.3	-0.8	-0.9	-0.8	0.9	1.0	1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.8	0.3	-0.1	-0.7	-0.3	0.5	0.7	0.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.3	0.2	0.6	0.3	0.8	0.7	0.0
Systolic blood pressure, automated reading	0.6	1.8	7.1	-2.7	-0.2	-0.5	-0.3	-0.6	-1.2	-1.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.3	1.0	1.8	0.2	-0.7	0.9	1.6	1.1
Angina	2.0	2.6	5.2	-1.9	1.1	1.2	1.3	-0.9	-2.0	-2.3
Medication for hormone replacement therapy	1.2	1.4	3.3	1.2	0.9	-0.4	-0.9	0.6	1.6	1.8
Vitamin and mineral supplements	0.6	0.9	2.7	-0.0	-0.3	-1.5	-1.7	0.9	-0.3	0.4
Supplements: Zinc	0.5	0.6	1.8	0.6	1.4	0.0	0.1	0.9	1.0	0.3
Medication: Co-codamol	1.4	1.6	9.0	-1.2	3.0	0.3	-0.2	-0.0	-0.5	-0.8
Medication: Metformin	0.8	1.1	1.6	1.1	1.3	-0.5	-1.3	0.7	0.8	1.3
Diabetes (father)	0.6	0.8	2.3	0.3	-0.6	1.5	1.2	-0.4	-0.7	-0.7
Diabetes (mother)	0.4	0.5	1.7	0.7	-1.3	0.2	0.1	-1.0	-0.5	0.3
Severe depression (siblings)	0.9	1.1	3.2	0.8	1.8	-0.1	-0.5	1.3	0.7	1.0
Pack years adult smoking proportion	1.1	1.6	2.9	1.3	0.8	-1.5	-1.1	1.7	1.2	1.1
Impedance of leg (right)	1.4	6.6	11.4	3.4	0.4	-1.6	-2.0	2.7	3.1	3.3
Leg fat-free mass (left)	0.1	0.3	0.9	-0.5	-0.6	0.9	0.6	-0.1	-0.6	0.1
Trunk fat percentage	0.2	0.8	2.1	0.1	-0.6	-0.3	-1.4	1.3	-0.7	0.9
Hand grip strength (right)	1.3	3.5	8.0	2.2	-2.8	0.0	-0.4	0.5	2.0	2.7
Townsend deprivation index at recruitment	0.2	0.3	1.1	-0.2	1.0	-0.3	-0.5	0.7	0.3	0.1
Current tobacco smoking	2.3	3.7	6.7	2.6	-0.2	-1.6	-1.6	2.3	1.8	2.3
Average weekly fortified wine intake	0.1	0.1	0.6	-0.4	0.8	0.1	-0.1	0.3	-0.3	-0.0
Maternal smoking around birth	2.4	3.4	5.8	2.0	0.6	-1.4	-1.7	2.4	2.0	2.3
Fed-up feelings	2.7	4.8	8.2	1.6	2.1	-2.2	-2.9	2.4	1.8	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	4.0	1.4	0.5	-0.8	-1.3	2.0	1.3	1.4
Relative age voice broke	0.2	0.3	1.2	-0.2	-1.1	0.5	0.8	-0.4	-0.4	-0.1
Taking other prescription medications	2.5	3.9	6.5	0.6	1.5	-2.5	-2.5	2.4	1.6	1.9
Age when periods started (menarche)	0.9	2.1	7.1	-0.3	-0.6	-2.7	-2.4	1.0	0.4	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.1	1.4	-0.4	-0.2	-0.6	0.3	0.8	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	5.7	-2.1	0.4	1.5	2.4	-1.3	-2.0	-2.4
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	6.4	2.2	-2.0	-1.2	-1.1	1.5	1.6	2.5
Qualifications: CSEs or equivalent	0.1	0.2	0.8	0.1	-0.3	0.1	0.2	-0.9	-0.2	-0.7
Serious illness, injury or assault to yourself	0.1	0.1	0.4	-0.0	-0.5	0.6	0.5	-0.3	-0.1	-0.3
High blood pressure	0.8	2.1	4.8	-2.2	-1.7	-0.2	-0.1	-1.5	-1.6	-1.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.4	-0.7	0.0	-0.6	-0.3	0.3	0.4
Multivitamins +/- minerals	0.6	0.7	1.8	0.3	0.2	1.3	1.3	-0.7	1.0	0.1
Stomach or abdominal pain in last month	1.6	2.1	3.7	1.6	0.3	-1.2	-1.8	1.0	1.5	1.9
Supplements: Glucosamine	1.2	1.5	3.6	-1.0	0.1	1.7	1.9	-1.3	-0.2	-1.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.2	-0.1	-0.2	-0.1
Medication: Atenolol	0.6	0.8	5.1	-0.4	2.3	0.3	0.1	0.2	-0.0	-0.3
Medication: Levothyroxine sodium	0.7	1.2	2.3	0.3	-1.4	-1.4	-1.5	0.2	0.9	1.1
Sitting height	0.1	0.6	2.5	0.9	-1.6	0.3	0.1	-0.2	0.1	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.4	-0.0	0.0	-0.8	0.4	0.1	0.7
High blood pressure (mother)	0.4	0.5	1.3	1.0	0.7	0.3	1.1	-0.8	0.4	-0.1
Body mass index (BMI)	0.7	3.0	8.9	-2.6	-0.6	1.1	0.2	-0.9	-3.0	-1.7
Impedance of leg (left)	1.4	6.7	10.9	3.2	0.5	-1.8	-2.2	2.6	3.1	3.3
Leg predicted mass (left)	0.1	0.3	0.7	-0.4	-0.6	0.9	0.5	-0.1	-0.6	0.1
Trunk fat mass	0.2	0.7	1.4	-0.0	-0.8	-0.1	-1.2	1.2	-0.7	0.9
Waist circumference	0.1	0.4	1.4	-0.1	0.4	0.0	-0.9	1.2	-0.6	0.4
Number of incorrect matches in round	0.1	0.2	0.5	-0.1	0.7	0.6	0.5	-0.4	-0.3	-0.5
Past tobacco smoking	0.1	0.3	0.6	-0.3	-0.7	0.8	0.6	0.2	0.5	0.0
Alcohol usually taken with meals	0.9	1.4	2.5	-1.0	-0.5	1.5	1.2	-1.6	-0.8	-1.3
Nervous feelings	0.3	0.6	3.1	0.4	1.8	-0.4	0.1	0.6	0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	7.3	2.4	-0.1	-1.7	-1.6	2.3	2.7	2.5
Hearing difficulty/problems with background noise	0.6	1.0	2.0	-1.0	-0.2	0.7	1.2	-1.4	-0.7	-1.2
Hair/balding pattern: Pattern 2	1.7	2.1	4.8	1.3	-2.2	-2.2	-1.4	0.9	-0.5	0.8
Had menopause	1.8	2.2	5.9	-2.4	0.4	1.5	0.7	-1.5	-1.2	-1.8
Had other major operations	2.5	3.0	5.4	1.7	0.5	-2.3	-1.7	2.0	1.6	1.8
Forced vital capacity (FVC)	0.3	1.2	3.5	-0.8	0.3	1.8	1.9	-0.8	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	4.2	-1.7	1.2	1.1	2.0	-0.8	-1.2	-1.9
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.9	1.1	2.0	-0.9	-0.8	0.9	1.3	0.7
Qualifications: None of the above	0.3	0.6	2.1	-0.2	0.4	-1.2	-1.5	0.3	-0.4	0.2
Financial difficulties in last 2 years	0.9	1.2	2.5	1.1	0.2	-1.6	-1.2	1.3	0.8	0.9
Mouth/teeth dental problems	0.1	0.2	1.2	-0.5	1.1	-0.1	0.3	0.1	0.1	-0.1
Heart attack	1.7	2.2	5.8	-1.8	0.2	0.9	0.9	-1.0	-2.4	-2.0
Allergy	0.1	0.2	0.7	-0.4	0.4	0.4	0.9	0.2	0.1	-0.2
Pain all over the body in last month	0.5	0.5	1.4	1.2	-0.3	-0.4	-0.8	0.5	0.5	0.9
Diabetes (self-reported)	0.6	0.9	3.0	0.6	0.6	-1.1	-1.7	0.7	0.4	0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	0.7	-1.0	-0.4	-0.7	-0.9	-0.1	0.2
Medication: Ramipril	0.2	0.3	1.6	0.4	1.2	0.0	0.1	0.2	0.4	0.1
Medication: Simvastatin	0.2	0.3	1.1	-0.5	0.5	1.0	0.4	-0.3	0.0	0.2
Fluid intelligence score	0.3	0.6	1.6	0.7	-0.9	1.3	0.9	0.5	-0.1	0.7
Illnesses of siblings	1.2	1.7	4.1	2.0	0.5	0.6	0.3	1.0	2.0	1.5
Neuroticism score	0.7	1.5	2.4	0.8	1.2	-1.5	-1.4	1.1	1.4	1.0
Weight	0.1	0.5	1.2	-0.8	-0.9	0.8	-0.1	0.3	-1.1	0.1
Impedance of arm (right)	1.6	7.5	21.1	4.6	-1.4	-1.0	-0.9	2.4	3.3	3.2
Arm fat percentage (right)	0.2	0.6	2.3	-0.6	-1.1	0.2	-0.6	0.5	-1.5	-0.2
Trunk fat-free mass	0.1	0.6	2.0	-0.9	-0.2	1.4	1.1	-0.5	-0.4	-0.1
Hip circumference	0.4	1.6	4.9	-1.9	-0.5	1.1	0.2	-0.1	-2.2	-1.0
Time employed in main current job	2.5	2.8	4.4	-1.7	-0.2	1.7	1.5	-1.9	-2.1	-1.9
Alcohol intake versus 10 years previously	2.1	3.1	6.2	1.4	0.6	-2.2	-2.5	2.0	1.3	1.8
Father’s age at death	0.7	0.9	3.1	1.1	0.0	1.8	1.1	0.2	0.9	0.2
Worrier / anxious feelings	0.4	0.8	2.9	0.5	0.0	1.3	1.7	-0.4	0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	5.3	1.9	-0.4	-1.4	-1.6	2.0	1.2	2.3
Falls in the last year	0.6	0.8	3.5	-0.6	1.9	0.8	0.3	-0.2	-0.4	-0.9
Hair/balding pattern: Pattern 3	0.7	1.0	5.1	-1.0	2.3	-0.2	-0.0	0.0	0.0	-1.0
Number of live births	1.1	1.6	3.7	-0.2	-1.5	-1.1	-1.9	1.4	1.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	-0.7	1.2	1.0	1.2	-0.4	0.1	-0.2
Pulse rate	2.9	4.9	9.7	2.9	1.0	-1.3	-1.4	2.2	2.6	3.1
Happiness	3.0	3.7	6.0	2.5	1.8	-1.3	-1.8	1.8	2.0	2.2
Noisy workplace	0.8	1.0	3.3	-1.8	-0.2	-0.3	-0.5	-0.5	-1.5	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.0	0.1	-0.2	1.6	1.7	-0.7	0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.9	-1.7	-0.9	0.5	1.0	-0.9	-1.0	-1.5
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.0	0.1	0.0	-0.1
Asthma	0.2	0.4	1.2	-0.6	0.3	0.1	-0.1	-0.4	-1.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.5	0.8	1.2	0.6	-0.2	0.5	1.2	0.9
Medication: Cholesterol lowering	0.8	1.2	2.8	-1.4	1.7	1.0	0.7	-0.7	-0.8	-1.1
Depression (self-reported)	0.6	0.7	3.0	0.1	0.3	-0.6	-0.0	1.7	1.2	0.1
Medication: Lansoprazole	0.8	0.9	2.0	0.9	0.1	-0.7	-1.0	1.2	0.7	1.4
Prospective memory result	0.6	0.8	2.0	1.1	-0.6	-0.1	0.1	0.9	1.4	0.9
Lung cancer (father)	1.0	1.2	4.9	-1.6	2.2	-0.1	-0.1	0.5	-0.4	-0.8
Illnesses of mother	0.7	0.8	2.0	-1.4	0.6	0.0	-0.3	-0.5	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.3	-1.0	0.4	1.8	1.8	-0.8	-0.1	-0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	1.0	1.0	-0.3	-0.6	0.4	0.2	1.0
Impedance of arm (left)	1.9	8.6	21.3	4.6	-1.5	-1.6	-1.6	2.7	3.5	3.5
Arm fat mass (right)	0.2	0.6	2.2	-0.9	-0.9	0.7	-0.1	0.2	-1.5	-0.3
Trunk predicted mass	0.1	0.7	2.2	-0.9	-0.1	1.5	1.2	-0.4	-0.4	-0.1
Standing height	0.7	7.3	15.9	3.6	-0.5	-0.4	-0.6	2.4	3.9	4.0
Length of working week for main job	1.1	1.3	2.8	0.8	1.6	-0.8	-0.6	1.1	1.7	0.9
Exposure to tobacco smoke at home	0.1	0.1	0.5	-0.1	0.7	-0.2	-0.2	0.1	-0.3	-0.1
Breastfed as a baby	4.5	5.6	10.8	-1.3	-0.8	2.6	2.5	-3.3	-2.8	-2.3
Tense / ‘highly strung’	2.6	4.2	8.3	2.1	1.7	-1.8	-1.1	2.3	2.9	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.0	6.1	11.2	2.1	2.7	-1.9	-1.8	3.3	2.7	2.3
Hair/balding pattern: Pattern 4	0.5	1.2	3.1	0.2	-0.4	1.8	1.2	-1.2	-1.3	-0.4
Birth weight of first child	0.3	0.6	1.4	-0.2	1.2	-0.8	-0.8	1.1	0.2	0.0
Peak expiratory flow (PEF)	0.2	0.4	1.0	-0.0	0.5	-1.0	-0.6	0.7	0.6	0.7
Pulse wave reflection index	0.3	0.4	0.9	-0.2	0.0	0.6	0.9	-0.5	-0.9	-0.8
Ever highly irritable/argumentative for 2 days	1.7	2.0	4.6	-1.1	2.1	1.3	1.6	-0.9	-0.3	-1.8
Loud music exposure frequency	0.9	1.0	2.4	0.9	0.9	-0.4	-0.4	1.2	1.5	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.8	1.3	0.0	0.4	0.4	0.5	1.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	0.2	1.2	-0.6	-0.9	0.1	-0.9	-0.2
Blood clot in the leg (DVT)	0.5	0.6	1.3	0.9	-1.2	0.6	0.6	0.3	0.5	1.0
Medication: Paracetamol	0.7	1.1	1.8	1.1	0.5	-0.7	-0.6	1.3	1.3	1.3
Headache pain in last month	1.5	2.5	5.3	2.3	-0.3	-1.3	-0.9	1.5	1.9	1.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.5	1.6	-0.7	-1.1	-0.7	1.0	0.8	1.0
Glaucoma (self-reported)	1.3	1.5	4.2	-1.6	2.0	0.8	1.2	-0.1	-0.5	-1.3
Gout (self-reported)	0.2	0.3	0.9	-0.5	-0.9	-0.3	-0.3	-0.7	-0.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.3	-0.8	-1.1	0.2	-0.5	-1.0	-0.0	0.0
Medication: Amlodipine	2.6	3.6	8.2	-2.9	0.5	1.0	1.5	-1.8	-2.2	-2.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.1	0.7	-0.8	-0.5	0.6	0.5	0.4
Birth weight	0.4	0.8	2.7	0.4	-0.8	1.4	1.6	-0.1	0.3	0.1
Chronic bronchitis/emphysema (mother)	2.2	2.6	3.9	1.4	-0.1	-1.7	-1.6	1.9	2.0	1.7
High blood pressure (siblings)	1.8	2.6	5.5	-2.0	-0.7	0.8	0.7	-1.8	-2.4	-1.9
Forced vital capacity (FVC), Best measure	0.6	2.3	6.0	-1.0	-0.0	2.4	2.4	-1.3	-0.5	-1.1
Body fat percentage	0.2	0.8	1.6	-0.5	-0.7	-0.3	-1.3	1.0	-1.3	0.4
Leg fat percentage (right)	0.4	1.5	5.5	-1.8	-0.5	0.3	-0.6	0.2	-2.4	-0.8
Arm fat-free mass (right)	0.0	0.2	0.6	-0.8	0.4	0.4	-0.1	0.2	-0.2	0.5
Exposure to tobacco smoke outside home	1.7	2.2	3.1	1.4	1.3	-1.6	-1.8	1.3	1.3	1.7
Comparative body size at age 10	2.4	6.5	11.5	-2.2	-0.9	2.8	3.4	-2.8	-2.2	-2.7
Number of full brothers	0.4	0.5	1.6	-1.0	-0.3	-0.1	-0.0	-0.6	-1.3	-0.6
Worry too long after embarrassment	1.2	2.1	3.2	-1.3	1.4	1.2	1.1	-1.8	-1.4	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	4.5	5.8	9.6	1.8	3.0	-2.2	-1.6	3.1	2.8	1.9
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	0.5	-0.0	-0.2	-0.5	1.2	0.1	0.8
Number of children fathered	0.2	0.2	0.9	0.3	-0.9	0.0	0.0	0.3	0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	0.8	0.3	0.4	0.6	0.4	0.9	0.4
Age at first live birth	0.6	1.1	4.4	-0.3	-0.5	1.3	2.1	-0.8	-0.2	-0.9
Pulse wave peak to peak time	0.3	0.4	0.9	-0.8	-0.9	0.4	0.6	-0.2	0.0	-0.8
Health satisfaction	1.3	1.7	3.1	1.8	0.6	-0.5	-1.2	1.4	1.3	1.7
Shortness of breath walking on level ground	0.5	0.6	2.2	1.2	0.4	-0.1	-0.1	1.5	0.6	0.3
Qualifications: College or University degree	0.7	2.2	8.4	1.1	-0.4	2.3	2.9	-0.1	0.2	-0.0
Eye problems/disorders: None of the above	0.6	0.6	1.8	0.4	-1.2	-1.3	-0.8	0.4	-0.6	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	1.2	-0.7	-0.1	-0.8	0.3	0.3	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	-0.4	0.3	-0.4	0.5	0.3	0.2
Medication for pain relief, constipation, heartburn	0.7	1.2	2.7	-0.4	-1.1	1.0	0.8	-1.6	-1.1	-1.2
Neck or shoulder pain in last month	1.0	1.4	2.2	1.1	0.9	-1.5	-1.2	1.0	1.4	1.0
Medication: Blood pressure	1.7	3.1	5.0	-2.2	0.1	2.1	1.8	-1.8	-1.4	-1.9
Angina (self-reported)	1.5	1.9	4.3	-1.7	0.7	0.8	1.1	-0.8	-1.8	-2.1
Migraine (self-reported)	2.1	2.6	4.7	1.7	0.2	-0.9	-1.3	2.0	2.2	2.0
Medication: Ibuprofen	0.8	0.9	2.5	1.3	0.9	0.5	0.0	0.4	1.6	1.1
Medication: Allopurinol	0.7	0.9	1.6	-1.0	-0.9	-0.1	-0.2	-1.2	-1.2	-1.3
Medication: Omeprazole	0.4	0.4	1.3	-0.3	0.9	-0.5	-0.6	1.2	0.1	0.4
Medication: Seretide 50 evohaler	0.3	0.4	0.9	-0.4	0.9	-0.8	-0.6	0.3	-0.3	-0.8
Mean time to correctly identify matches	0.6	1.2	6.9	-0.4	2.6	0.7	0.3	0.7	-0.0	-0.1
Heart disease (mother)	0.6	0.7	1.8	1.0	-0.3	-0.5	-0.3	0.6	1.4	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.8	0.7	0.2	-1.4	-1.9	1.6	1.5	1.5
Whole body fat mass	0.1	0.6	1.1	-0.5	-0.8	-0.0	-1.1	0.9	-1.1	0.4
Leg fat mass (right)	0.3	1.1	4.1	-1.4	-0.8	0.5	-0.5	0.1	-2.0	-0.4
Arm predicted mass (right)	0.0	0.1	0.6	-0.7	0.3	0.2	-0.2	0.2	-0.1	0.5
Pulse rate, automated reading	0.8	2.5	6.3	2.5	0.0	0.0	0.2	1.5	1.9	2.4
Alcohol intake frequency.	0.0	0.1	0.3	0.0	0.5	0.1	-0.2	0.3	0.3	-0.2
Comparative height size at age 10	1.5	8.4	16.6	3.9	-0.6	-1.1	-1.2	3.0	4.1	3.9
Number of full sisters	1.4	1.6	5.2	-0.6	2.3	-1.7	-1.6	0.0	0.7	0.4
Suffer from ‘nerves’	1.9	2.9	4.3	1.1	1.6	-1.8	-1.7	1.9	2.1	1.6
Overall health rating	0.7	1.5	2.9	1.4	0.7	-0.5	-1.0	1.7	1.2	1.5
Chest pain or discomfort	0.8	1.2	2.5	1.0	0.5	-0.9	-1.3	1.6	0.9	1.1
Had major operations	2.3	2.6	4.2	1.5	0.2	-1.8	-1.3	2.0	1.9	2.0
Age at last live birth	0.1	0.2	0.6	0.1	-0.1	-0.8	-0.4	0.5	0.6	0.2
Family relationship satisfaction	0.9	1.2	3.6	0.9	1.9	-0.7	-1.0	0.9	0.8	0.9
Leg pain on walking	0.2	0.2	0.9	0.3	0.0	0.9	0.3	-0.5	-0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	0.3	0.4	0.1	-0.4	0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.3	0.1	0.1	0.4	-0.0	-0.3	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-1.0	0.9	0.8	0.4	-0.6	-0.3	-0.5
Medication: Aspirin	0.5	0.6	1.7	-0.4	0.9	-1.3	-0.8	1.0	0.2	0.5
Supplements: Vitamin C	0.4	0.4	1.5	-0.3	-0.5	-0.6	0.4	-1.2	-0.4	-0.7
Knee pain experienced in last month	0.1	0.2	0.4	-0.6	-0.5	0.0	-0.2	0.6	0.1	-0.2
Hypertension (Self-reported)	0.5	1.4	3.5	-1.9	-1.1	-0.4	-0.2	-1.3	-1.3	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.6	1.5	0.6	-1.2	-1.6	1.8	1.4	2.2
Illnesses of father: Heart disease	1.1	1.5	5.0	-2.2	0.0	0.7	1.1	-0.6	-1.2	-1.4
Illnesses of siblings: Diabetes	0.3	0.4	1.5	-0.6	-0.7	-0.3	-0.6	0.1	-1.2	-0.3
Smoking status: Previous	0.4	0.6	1.1	-0.6	0.7	-0.2	0.0	-1.1	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.4	1.9	-0.5	-0.2	-0.7	0.9	1.3	1.8
Whole body fat-free mass	0.1	0.3	1.1	-0.7	-0.3	1.0	0.7	-0.1	-0.3	0.2
Leg fat-free mass (right)	0.0	0.2	0.6	-0.5	-0.6	0.8	0.5	-0.1	-0.4	0.1
Arm fat percentage (left)	0.2	0.7	2.3	-0.5	-1.2	-0.1	-0.9	0.6	-1.5	-0.0
Average weekly red wine intake	0.2	0.3	0.6	0.8	-0.7	0.0	-0.1	0.1	0.7	0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	-0.3	-1.1	-1.2	-0.9	-0.6	-0.5	-0.1
Mood swings	2.0	3.5	6.6	1.9	1.9	-1.4	-1.2	1.9	2.6	2.0
Loneliness, isolation	0.2	0.3	1.0	0.4	0.5	-0.4	-1.0	0.4	0.2	0.7
Long-standing illness, disability or infirmity	0.0	0.1	0.2	0.1	0.1	-0.4	-0.4	0.2	0.2	0.3
Ever had bowel cancer screening	0.5	0.6	1.3	0.7	0.8	0.8	0.2	0.5	1.1	0.6
Diabetes diagnosed by doctor	0.6	0.9	3.5	0.6	0.5	-0.9	-1.9	0.8	0.3	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.6	0.2	-1.0	-1.6	-1.6	1.5	0.6	1.1
Friendships satisfaction	1.9	2.4	4.3	1.6	0.3	-1.4	-2.1	1.4	1.3	2.0
Qualifications: nursing, teaching	0.3	0.5	1.0	0.5	-0.7	0.6	0.9	0.3	1.0	0.4
Commuting to job workplace: Walk	1.6	1.7	4.9	-0.6	0.3	2.2	2.0	-0.5	-0.6	-1.3
Eye problems/disorders: Cataract	0.4	0.5	1.0	-0.6	1.0	-0.2	-0.0	1.0	0.9	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.0	0.3	0.3	1.0	1.7	0.7	0.3	-0.0
Medication for cholesterol	1.6	2.5	4.5	-1.0	0.4	1.7	1.9	-1.7	-1.5	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.6	1.1	1.6	-0.0	-0.4	1.9	1.9	1.9
Back pain experienced in last month	1.1	1.7	4.1	-0.7	1.6	2.0	1.8	-0.6	-0.4	-0.8
Mineral and other dietary supplements	2.6	3.5	5.7	2.1	-1.1	-2.0	-2.4	1.9	0.9	2.1
Breast cancer (self-reported)	0.6	0.7	2.0	0.7	0.5	-0.8	-0.2	1.4	0.9	0.9
Asthma (self-reported)	0.1	0.2	0.8	-0.4	0.2	-0.0	-0.3	-0.3	-0.9	-0.6
Osteoporosis (self-reported)	1.2	1.4	3.3	1.8	-1.6	-0.3	-0.8	1.0	0.5	1.4
Osteoarthritis (self-reported)	0.2	0.3	1.2	0.4	-0.5	0.0	0.2	1.1	0.4	0.5
Medication: Aspirin	1.1	1.5	3.1	-0.1	1.4	-1.8	-1.0	1.7	0.7	0.9
Medication: Gliclazide	0.4	0.5	1.1	-0.0	-1.0	0.6	-0.1	-1.0	-1.0	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.4	-0.3	-0.8	-0.8	-0.1	0.0	0.3
Smoking status: Current	1.9	3.0	5.5	2.4	-0.4	-1.5	-1.5	2.1	1.4	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.7	7.8	13.8	-3.7	0.7	2.4	2.6	-3.2	-2.5	-3.4
Whole body water mass	0.1	0.4	1.2	-0.7	-0.2	1.1	0.7	-0.2	-0.4	0.1
Leg predicted mass (right)	0.0	0.2	0.6	-0.4	-0.6	0.8	0.4	-0.1	-0.4	0.2
Arm fat mass (left)	0.1	0.6	1.7	-0.7	-1.0	0.3	-0.5	0.5	-1.3	0.0
Number of self-reported non-cancer illnesses	1.1	1.9	3.0	1.2	-1.5	-1.6	-1.7	0.8	1.1	1.6
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.5	0.2	0.0	-0.1	0.1	-0.4	-0.6
Miserableness	0.4	0.7	1.7	0.7	0.3	-1.1	-1.3	1.0	0.3	0.8
Guilty feelings	0.7	1.0	2.9	1.7	0.1	-0.8	-1.0	0.3	0.6	1.5
Wears glasses or contact lenses	0.7	0.8	1.7	-1.3	0.3	-0.2	-0.9	-0.9	-1.1	-1.0
Ever taken oral contraceptive pill	2.0	2.2	3.9	1.7	1.1	-1.4	-1.1	2.0	1.4	1.7
Hearing aid user	0.5	0.6	2.5	0.5	-1.6	-0.1	-0.5	0.7	0.6	0.6
Mother’s age at death	1.2	1.5	3.1	-1.2	1.4	0.9	1.2	-1.0	-1.0	-1.8
Financial situation satisfaction	2.5	3.0	9.5	1.0	3.1	-1.5	-1.4	1.4	1.6	1.4
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.2	1.3	-1.0	1.1	1.5	-0.2	0.9	0.4
Commuting to job workplace: Public transport	0.9	1.1	3.9	1.5	-2.0	-0.1	-0.3	-0.1	0.9	0.9
Eye problems/disorders: Glaucoma	0.4	0.5	2.6	-0.4	1.6	0.6	0.6	-0.1	0.2	-0.5
Medication: Blood pressure	0.3	0.6	1.8	-0.4	-0.6	-1.3	-1.1	0.7	0.3	0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.9	4.2	-0.3	2.0	-0.4	-0.9	0.9	0.0	0.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.1	-1.8	0.6	1.3	1.3	-1.3	-0.7	-1.3
High cholesterol (Self-reported)	0.3	0.5	1.7	0.3	-0.6	1.3	1.1	0.2	0.5	0.3
Medication: Bendroflumethiazide	0.9	1.3	3.4	-1.6	-1.8	-0.4	-0.5	-0.9	-1.2	-0.8
Medication: Paracetamol	0.5	0.7	1.2	0.9	0.5	-0.3	-0.4	1.0	1.1	1.1
Medication: Lisinopril	0.3	0.4	1.4	-0.0	-1.2	1.1	0.1	-0.4	-0.2	0.4
Medication: Atorvastatin	1.3	1.7	2.5	-1.5	-0.2	1.1	1.0	-1.6	-1.5	-1.6
Illnesses of father: High blood pressure	1.0	1.3	3.3	0.9	0.1	-1.2	-0.8	1.3	1.8	1.1
Alcohol drinker status: Never	0.5	0.6	1.3	1.0	-0.4	-0.6	-1.1	0.7	0.6	0.8
Ever smoked	0.3	0.6	1.5	0.9	1.2	-0.7	-0.4	0.7	0.5	0.8
Basal metabolic rate	0.1	0.3	1.0	-0.7	-0.3	1.0	0.6	-0.0	-0.5	0.1
Leg fat percentage (left)	0.5	1.6	5.9	-2.0	-0.3	0.3	-0.6	-0.1	-2.4	-1.0
Arm fat-free mass (left)	0.0	0.2	0.8	-0.9	0.2	0.7	0.4	0.1	-0.4	0.2
Number of operations (self-reported)	3.2	4.8	7.2	2.2	-0.1	-2.4	-2.0	2.3	2.5	2.7
Average weekly beer plus cider intake	5.5	7.9	15.4	1.5	1.4	-3.8	-3.9	2.6	2.3	3.0
Irritability	0.6	1.1	2.0	1.2	-0.5	-1.0	-0.8	0.3	1.4	1.3
Risk taking	0.1	0.2	0.6	-0.2	0.2	-0.2	0.8	-0.4	0.4	-0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	1.2	-0.1	1.3	1.3	-0.8	0.5	-0.1
Fractured/broken bones in last 5 years	0.8	1.0	4.2	-0.2	2.0	1.1	1.1	-0.3	0.2	-0.5
Age started oral contraceptive pill	3.3	4.1	7.2	-2.7	1.0	1.3	2.4	-2.0	-1.7	-2.5
Diastolic blood pressure, automated reading	0.3	0.8	2.3	-1.5	-0.9	-0.8	-1.1	0.4	-0.1	-0.4
Ever depressed for a whole week	1.3	1.6	2.3	1.5	1.4	-1.5	-1.2	1.3	0.9	0.7
Unable to work because of sickness or disability	0.6	0.7	1.6	0.3	0.8	-1.3	-1.2	0.5	0.9	0.5
Commuting to job workplace: Cycle	1.5	1.8	6.4	-0.4	0.0	1.7	2.5	-0.9	-0.6	-1.4
Myopia	1.7	2.5	4.4	-1.3	-1.4	0.9	1.8	-1.2	-2.1	-1.9
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.4	2.5	1.4	-0.2	-0.3	1.8	2.0	2.0
Cholesterol lowering medication	0.2	0.3	1.4	0.3	-1.2	0.4	0.2	-0.4	0.0	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.7	-0.3	1.4	-0.7	-0.7	1.6	0.2	0.4
Pain experienced in last month	0.3	0.6	2.7	-0.5	-1.7	-0.2	-0.4	-0.6	-0.6	-0.2
Supplements: Calcium	0.2	0.2	0.5	-0.7	-0.3	-0.1	0.0	-0.1	-0.7	-0.5
Basal cell carcinoma (self-reported)	1.2	1.5	5.5	-1.7	2.3	0.4	0.3	-0.6	-0.6	-0.9
Heart attack/myocardial infarction (self-reported)	1.4	1.9	5.2	-1.7	0.2	0.7	0.8	-0.8	-2.3	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	1.0	-1.0	0.7	0.5	0.4	0.7	1.1
Heart disease (siblings)	0.5	0.6	2.6	-0.6	0.0	-1.6	-0.7	0.5	0.4	0.2
Alcohol drinker status: Previous	0.2	0.3	1.0	-0.7	-0.1	-0.1	0.5	-0.0	-0.3	-1.0
Pack years of smoking	0.7	1.0	1.9	0.9	1.0	-1.2	-0.9	1.4	0.8	0.7
Impedance of whole body	2.4	12.1	25.0	5.0	-0.6	-2.4	-2.4	3.4	4.2	4.3
Leg fat mass (left)	0.3	1.2	4.4	-1.6	-0.8	0.5	-0.5	-0.0	-2.1	-0.5
Arm predicted mass (left)	0.0	0.2	0.5	-0.7	0.3	0.7	0.3	0.1	-0.2	0.3