Hub : Genes

THAP8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1210 0.0480 2.2e-03 0.028 NA 0.008 NA 0.001 1.1e-02 NA 1.2e-01 NA 2.8e-01
2 GTEx Cells Transformed fibroblasts 0.1940 0.0440 4.1e-09 0.202 NA 0.173 NA 0.197 4.0e-15 NA 5.7e-13 NA 1.0e-14
3 GTEx Skin Sun Exposed Lower leg 0.2560 0.0560 9.9e-07 0.070 NA 0.116 NA 0.078 1.9e-06 NA 8.5e-10 NA 5.1e-07
4 GTEx Whole Blood 0.0930 0.0380 1.6e-03 0.003 NA 0.029 NA 0.003 1.5e-01 NA 1.1e-03 NA 1.7e-01
5 TCGA Glioblastoma Multiforme 0.2230 0.0860 4.0e-06 0.240 0.215 0.197 NA 0.209 6.7e-08 3.8e-07 1.2e-06 NA 5.5e-07
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0522 0.0305 2.1e-03 0.005 0.019 0.014 NA 0.013 8.6e-02 2.7e-03 9.3e-03 NA 1.2e-02
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0943 0.0513 2.1e-06 0.065 0.050 0.047 NA 0.058 7.4e-08 2.6e-06 4.8e-06 NA 3.8e-07
8 TCGA Lung Adenocarcinoma 0.0332 0.0205 7.0e-04 0.044 0.032 0.039 NA 0.042 7.1e-06 1.2e-04 2.3e-05 NA 9.8e-06
9 TCGA Prostate Adenocarcinoma 0.0310 0.0178 1.9e-03 0.031 0.021 0.020 NA 0.020 3.1e-04 2.8e-03 3.0e-03 NA 3.0e-03
10 TCGA Stomach Adenocarcinoma 0.0620 0.0350 1.9e-04 0.054 0.054 0.048 NA 0.059 9.0e-05 8.9e-05 2.2e-04 NA 4.1e-05
11 TCGA Thyroid Carcinoma 0.0550 0.0260 2.8e-05 0.038 0.039 0.042 NA 0.040 1.3e-04 9.6e-05 5.6e-05 NA 8.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.2 0.4 0.9 0.2 0.6 0.8 0.1 0.7 1.0 0.6 0.5 0.1 0.9 0.5
Bipolar Disorder or Schizophrenia 0.1 0.1 0.7 0.4 0.3 0.2 -0.2 0.8 -0.3 0.2 0.0 0.1 0.4 0.2
Depressed Affect (Nagel 2018) 0.2 0.4 1.7 0.2 -0.4 -0.7 -1.3 -0.4 -0.9 -0.5 -0.5 -0.2 -0.4 -0.4
Depression (Nagel 2018) 0.7 1.0 2.2 1.5 0.8 -1.3 -0.5 1.1 0.9 0.9 0.9 1.2 0.5 1.0
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.6 -0.5 0.8 1.5 0.7 0.6 1.6 0.9 0.8 0.3 1.1 0.8
Neuroticism (Nagel 2018) 0.3 0.6 3.0 1.1 0.0 -1.7 -0.6 0.3 -1.5 -0.3 -0.3 0.2 -0.3 0.1
Schizophrenia (2018) 0.1 0.2 1.3 0.4 -0.1 -0.5 -0.4 0.5 -1.1 -0.3 -0.3 0.1 -0.2 -0.2
Schizophrenia vs Biploar Disorder 0.6 0.8 2.8 0.1 1.0 0.0 1.7 0.9 -0.5 0.9 1.0 1.2 0.5 1.1
Worry (Nagel 2018) 0.4 0.9 5.6 1.2 0.2 -2.4 0.2 0.5 -1.5 -0.1 -0.0 0.3 0.1 0.4
Alzheimer’s Disease (in mother) 5.0 5.9 13.4 -0.2 -2.7 0.2 -0.6 -2.8 -3.7 -3.0 -2.8 -2.3 -2.0 -3.1
Alzheimer’s Disease (in father) 0.4 0.4 1.5 1.2 0.5 -0.5 -1.1 0.5 -0.1 0.5 0.5 0.6 0.3 0.4
Alzheimer’s Disease (including proxy) 3.2 4.6 11.0 0.6 -2.3 -0.9 -1.3 -2.4 -3.3 -2.6 -2.4 -1.8 -1.9 -2.5
Crohns Disease (2017) 0.3 0.7 2.7 1.1 0.0 -1.6 -0.7 -0.2 -1.6 -0.3 -0.4 -0.0 -0.2 -0.3
Irritable Bowel Disease (IBD) 0.7 1.7 7.7 2.0 1.2 -2.8 -1.2 0.7 -1.1 0.8 0.6 1.1 0.5 0.8
Ulcerative Colitis (UC) 0.9 1.7 7.1 1.6 1.4 -2.7 -0.8 0.8 -0.6 1.1 1.0 1.2 0.7 1.1
Major Depression (MDD) 0.7 0.9 2.7 0.5 0.8 1.7 1.2 0.7 -0.2 0.7 0.8 0.8 1.5 -0.0
Reaction Time 0.3 0.6 3.2 -0.3 -0.7 1.0 -1.8 -0.3 -0.2 -0.6 -0.4 -0.8 -0.2 -1.0
Verbal and Numeric Reasoning (VNR) 0.1 0.2 1.1 -0.0 0.2 0.1 1.0 0.1 0.7 0.3 0.2 -0.1 0.0 0.5
Breast Cancer 0.0 0.1 0.6 0.4 0.1 0.5 -0.8 0.0 0.4 0.1 -0.1 0.3 -0.1 -0.0
Ovarian Cancer 1.2 1.6 4.3 -2.1 -1.4 0.6 -1.0 -1.2 0.8 -1.3 -1.3 -1.6 -1.4 -0.8
Prostate Cancer 1.6 2.2 5.2 0.7 1.6 -0.2 1.1 1.5 1.6 1.8 1.9 1.1 1.5 2.3
Age at First Birth 0.3 0.5 2.8 -0.4 0.5 -0.5 1.7 0.2 -0.8 0.3 0.3 0.6 0.5 0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.7 0.8 0.4 -0.4 -0.8 0.0 -0.4 0.3 0.3 0.4 0.2 0.2
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.2 0.5 -0.5 0.4 0.6 0.2 0.5 0.5 0.5 0.4 0.4
Crohns Disease (2012) 0.4 0.6 4.9 0.5 -0.1 -0.4 0.3 -0.2 -2.2 -0.5 -0.5 -0.1 0.4 -0.7
Mean Putamen Volume 1.4 1.6 3.5 -1.1 -1.2 1.7 1.5 -1.1 1.9 -0.8 -0.8 -1.5 -0.8 -1.1
Fasting Glucose 2.7 3.2 5.4 -2.3 -2.0 0.9 -1.0 -2.0 -0.5 -2.0 -2.0 -2.2 -1.9 -2.0
HbA1C 0.7 0.8 1.5 -1.2 -1.1 0.0 -0.4 -0.9 0.9 -0.9 -0.9 -1.2 -0.9 -0.9
HDL Cholesterol 0.4 0.7 3.3 -0.4 -0.4 0.6 -0.5 -1.0 -1.8 -0.7 -0.7 -0.9 -0.5 -0.8
LDL Cholesterol 0.4 0.6 1.7 -0.1 -1.1 -1.3 -0.1 -0.6 0.2 -1.0 -1.1 -0.6 -1.0 -0.5
Lupus 0.4 0.6 1.8 0.8 0.7 -0.9 -0.9 0.5 0.4 0.8 1.1 0.3 0.2 1.3
Neuroticism (2016) 0.1 0.2 0.8 0.5 0.2 0.5 -0.9 0.3 -0.6 0.1 -0.1 0.3 0.2 0.0
Primary Biliary Cirrhosis 0.3 0.4 1.7 -0.2 0.5 -0.5 -1.3 0.1 0.5 0.6 0.7 0.3 0.7 0.2
Rheumatoid Arthritis 0.2 0.3 1.3 -0.0 0.3 -0.6 -1.1 0.2 0.8 0.4 0.4 0.0 0.2 0.4
Schizophrenia (2014) 0.6 1.4 3.8 1.0 1.3 -0.2 -0.1 1.9 0.2 1.3 1.4 1.6 1.0 1.3
Triglycerides 0.5 0.8 2.3 0.4 0.7 -0.2 0.7 1.0 1.5 0.9 0.8 1.1 0.8 0.9
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.1 0.2 0.6 0.3 -0.2 -0.0 0.2 0.3 -0.4 0.0 0.2
Ulcerative Colitis 1.4 2.1 5.6 1.7 1.4 -2.4 -0.4 1.5 0.7 1.3 1.4 1.5 1.0 1.7
Blood Eosinophil Count 0.1 0.5 2.3 -0.8 -0.7 0.5 1.5 0.2 0.7 -0.5 -0.3 -0.8 -0.5 -0.4
Blood Platelet Count 0.6 6.9 29.5 1.4 2.1 -0.2 5.4 3.0 2.1 2.3 2.2 2.0 2.2 2.7
Blood Red Count 0.2 1.7 4.0 -2.0 -1.6 1.0 0.3 -0.9 1.1 -1.3 -1.3 -1.4 -1.9 -0.5
Blood White Count 0.0 0.2 1.1 -0.1 -0.4 -1.0 -0.1 0.1 0.7 -0.2 -0.0 0.5 -0.5 -0.3
Heel T-Score 0.4 2.8 5.5 2.3 2.0 -0.3 0.9 1.6 -1.0 1.7 1.6 2.1 2.2 1.6
BMI 0.8 4.4 9.2 -2.6 -2.5 3.0 -0.1 -1.8 1.3 -2.1 -2.0 -2.3 -1.8 -2.2
Height 0.2 4.7 11.1 -0.8 -2.0 -2.3 -1.9 -2.5 -3.3 -2.3 -2.0 -2.2 -1.7 -1.9
Waist Hip Ratio (WHR) 0.2 1.1 4.5 -0.2 -0.7 -1.4 -2.1 -1.0 -0.6 -0.8 -0.7 -1.0 -1.1 -0.3
Systolic Blood Pressure 0.1 0.4 2.4 -0.9 -0.4 0.1 -0.1 -0.2 -1.5 -0.6 -0.4 -0.9 -0.0 -0.6
Smoking Status 0.8 1.8 17.0 0.1 -0.4 -0.6 -4.1 -0.5 0.8 -0.3 -0.2 -0.8 -1.0 0.2
Allergy or Eczema 0.5 1.3 3.2 0.0 -1.2 -1.4 -1.8 -0.9 -0.1 -1.2 -1.1 -1.2 -1.3 -0.7
Cardiovascular Disease 0.1 0.4 2.5 1.0 0.2 -0.8 -0.3 0.3 -1.6 -0.0 0.2 0.2 0.5 0.4
Hypothyroidism (self reported) 0.2 0.6 1.9 1.0 0.6 -1.4 0.2 0.5 -1.2 0.4 0.4 0.4 0.8 0.3
Respiratory disease 0.3 0.7 3.1 1.8 0.4 -0.8 -1.0 0.4 -1.5 0.2 0.4 0.5 0.5 0.1
Type 2 Diabetes (T2D) (2018) 1.2 2.3 4.4 -0.5 -1.7 0.6 -2.1 -1.9 -1.1 -1.7 -1.7 -1.6 -1.3 -1.7
Lung FEV1/FVC ratio 0.3 1.5 3.6 -0.4 -1.8 -0.6 0.6 -0.5 1.3 -1.5 -1.6 -0.8 -1.9 -1.1
Lung FVC 0.9 4.7 8.1 2.5 2.3 -2.8 -1.3 2.0 0.7 2.2 2.1 2.5 1.6 2.8
Neuroticism 0.2 0.6 2.5 1.2 0.6 -0.8 0.3 0.6 -1.6 0.3 0.3 0.6 0.6 0.4
Chronotype (morning person) 0.0 0.1 0.2 0.1 -0.1 0.1 -0.2 0.3 0.3 -0.2 -0.2 -0.4 -0.2 0.4
Hair Pigment 0.1 2.5 3.7 -1.9 -1.8 1.1 -0.6 -1.6 -0.6 -1.8 -1.9 -1.7 -1.9 -1.7
Tanning 0.3 4.0 6.2 1.8 2.2 0.6 2.0 2.0 1.2 2.3 2.2 2.4 2.5 2.0
Hand grip strength (left) 0.3 0.9 1.6 -1.1 -1.3 0.5 0.2 -0.8 0.2 -1.2 -1.3 -0.9 -1.1 -1.0
Number of treatments/medications taken 1.6 2.8 6.6 -0.8 -1.6 -0.9 -1.4 -1.5 -2.6 -2.0 -2.0 -1.7 -1.7 -1.8
Average weekly spirits intake 0.6 0.7 2.5 -0.7 -0.4 1.6 0.8 -0.5 -1.5 -0.4 -0.2 -0.9 0.3 -0.8
Sensitivity / hurt feelings 0.8 1.3 2.7 -0.6 -1.5 -0.3 -0.0 -0.9 -0.6 -1.6 -1.6 -1.4 -1.5 -1.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 0.6 -0.5 -0.5 1.1 -0.0 0.4 -0.4 -0.4 0.2 -0.4 -0.3
Hearing difficulty/problems: Yes 0.5 0.8 3.3 -0.3 -1.0 -0.4 -0.3 -0.4 1.8 -0.8 -0.9 -0.7 -1.4 -0.2
Relative age of first facial hair 0.8 1.6 4.8 -0.7 -1.0 -0.5 -1.4 -1.5 -2.2 -1.3 -1.1 -1.1 -1.1 -1.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 1.1 -1.1 -0.5 -0.3 -0.2 -0.2 1.0 -0.4 -0.4 -0.8 -0.3 -0.4
Ever used hormone-replacement therapy (HRT) 1.1 1.3 2.5 1.2 1.6 -0.3 -0.1 1.0 -1.1 1.4 1.4 1.5 1.5 0.3
Ever had hysterectomy (womb removed) 0.4 0.4 0.9 -0.3 -0.8 0.2 -0.9 -0.6 0.2 -0.7 -0.8 -0.9 -0.5 -0.7
Systolic blood pressure, automated reading 0.5 1.4 2.9 -1.7 -1.5 0.3 -0.3 -0.8 -0.5 -1.4 -1.2 -1.6 -1.2 -1.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.6 0.5 -0.9 -1.3 -1.1 -0.3 -0.7 -0.9 -0.8 -0.5 -0.8 -0.6
Angina 0.1 0.1 0.9 -0.4 0.2 0.9 0.2 -0.4 -0.1 0.2 0.1 -0.1 0.4 -0.3
Medication for hormone replacement therapy 0.5 0.6 1.1 1.1 0.9 -0.9 -0.4 0.4 -1.0 0.6 0.6 1.0 0.8 0.0
Vitamin and mineral supplements 0.3 0.4 2.4 -1.5 -0.2 0.2 -0.5 -0.5 0.9 -0.1 -0.1 -0.3 -0.3 -0.4
Supplements: Zinc 0.5 0.6 3.3 0.2 -0.2 0.3 1.1 -0.6 -1.8 -0.5 -0.5 -0.3 0.1 -0.6
Medication: Co-codamol 1.8 2.1 5.4 -2.3 -1.1 2.1 -0.1 -1.5 -1.3 -1.2 -1.1 -1.5 -0.4 -1.7
Medication: Metformin 2.5 3.6 8.5 -0.6 -2.1 0.7 -2.9 -2.1 -0.5 -2.1 -2.1 -2.4 -1.8 -1.7
Diabetes (father) 0.6 0.7 0.9 -0.8 -1.0 0.4 -1.0 -0.9 -0.5 -1.0 -0.9 -0.9 -0.7 -1.0
Diabetes (mother) 0.9 1.1 2.6 -1.4 -1.2 1.0 0.5 -1.0 -0.3 -1.1 -1.1 -0.8 -0.9 -1.6
Severe depression (siblings) 0.9 1.1 2.2 1.1 1.2 -1.5 0.9 1.2 -0.6 0.9 0.9 0.9 1.0 0.9
Pack years adult smoking proportion 0.4 0.5 1.4 -0.4 -0.9 -0.0 -1.2 -0.6 0.4 -0.8 -0.8 -0.9 -0.8 -0.6
Impedance of leg (right) 0.2 1.0 4.8 0.6 0.7 -1.2 2.2 -0.2 -1.6 0.3 0.4 0.3 0.5 0.4
Leg fat-free mass (left) 0.5 2.8 3.9 -2.0 -1.9 1.8 -1.8 -1.4 0.3 -1.7 -1.7 -1.9 -1.5 -1.9
Trunk fat percentage 1.0 4.1 7.1 -2.6 -2.3 2.2 0.5 -2.0 0.1 -2.1 -2.0 -2.7 -1.9 -2.1
Hand grip strength (right) 0.1 0.2 0.6 -0.6 -0.6 0.3 0.0 -0.3 0.8 -0.5 -0.5 -0.3 -0.6 -0.2
Townsend deprivation index at recruitment 0.8 1.1 4.5 -1.2 -0.7 2.1 1.5 -0.1 0.6 -0.6 -0.5 -0.4 -0.2 -1.2
Current tobacco smoking 0.4 0.7 3.7 -0.5 -0.4 0.2 -1.7 -0.2 1.9 -0.1 -0.1 -0.3 -0.3 -0.3
Average weekly fortified wine intake 0.6 0.8 4.7 -0.1 -0.1 0.2 -1.1 -1.3 -2.2 -0.4 -0.3 -0.5 -0.1 -0.6
Maternal smoking around birth 1.0 1.5 2.4 -1.0 -1.3 1.4 1.1 -0.5 1.6 -1.1 -1.2 -1.3 -1.4 -1.0
Fed-up feelings 0.2 0.3 2.1 0.5 -0.2 0.1 0.6 -0.4 -1.5 -0.4 -0.4 0.1 -0.0 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 0.6 -0.1 -0.4 0.2 0.2 0.1 -0.0 0.0 0.2 -0.1 -0.1
Relative age voice broke 0.6 1.0 2.7 1.6 0.8 -1.2 0.4 0.6 -1.6 0.5 0.6 1.2 0.6 0.8
Taking other prescription medications 0.7 1.1 5.3 -0.2 -0.3 -1.1 -2.3 -1.1 -1.4 -0.6 -0.6 -0.8 -0.8 -0.7
Age when periods started (menarche) 0.3 0.8 4.8 0.4 -0.4 -2.2 -1.3 -0.3 0.1 -0.5 -0.4 -0.1 -1.1 -0.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.3 0.2 0.3 1.1 0.2 0.3 -1.2 0.1 0.1 0.1 0.6 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 0.6 0.6 0.0 1.1 0.9 0.0 0.5 0.5 0.5 0.8 0.8
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.4 -0.2 -0.1 0.3 0.4 -0.3 0.6 -0.1 -0.1 -0.1 -0.5 -0.1
Qualifications: CSEs or equivalent 2.8 3.6 6.5 -0.3 -2.5 0.3 -0.5 -2.2 -0.5 -2.5 -2.4 -2.2 -2.3 -2.5
Serious illness, injury or assault to yourself 1.9 2.3 4.0 -1.6 -1.8 0.3 -0.0 -1.8 -0.4 -1.7 -1.6 -2.0 -1.7 -1.8
High blood pressure 0.1 0.3 1.2 0.4 0.5 -0.7 -0.3 0.4 -1.1 0.3 0.5 0.5 0.3 0.5
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.1 0.2 -0.8 -1.1 -1.8 -0.7 -0.7 -0.9 -0.9 -0.8 -0.9 -0.6
Multivitamins +/- minerals 0.1 0.1 0.5 0.7 -0.3 -0.0 0.2 0.2 -0.7 -0.4 -0.3 -0.2 -0.1 -0.1
Stomach or abdominal pain in last month 0.1 0.1 0.3 0.0 0.4 0.6 0.1 0.3 -0.6 0.2 0.2 0.4 0.2 0.4
Supplements: Glucosamine 0.4 0.5 2.9 0.4 0.2 1.2 1.7 0.1 -0.9 0.1 0.2 -0.1 0.2 0.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 4.0 1.0 0.0 0.0 2.0 0.3 -1.1 -0.2 -0.3 0.7 0.1 -0.5
Medication: Atenolol 0.4 0.5 1.0 0.5 0.8 0.4 0.6 0.2 0.7 1.0 1.0 0.5 0.8 0.6
Medication: Levothyroxine sodium 0.2 0.4 3.2 -0.0 0.2 -1.8 -0.9 0.1 0.3 0.2 0.2 -0.5 -0.0 0.4
Sitting height 0.1 0.7 3.4 0.1 0.8 -0.3 -1.0 -0.0 -1.8 0.6 0.7 0.5 1.1 0.2
Chronic bronchitis/emphysema (father) 3.3 3.8 7.0 -2.6 -2.0 2.1 -1.0 -2.2 -0.2 -1.9 -1.9 -2.3 -1.7 -2.3
High blood pressure (mother) 0.2 0.3 1.9 -0.2 -0.4 -0.6 1.4 0.1 -0.0 -0.4 -0.5 -0.4 -0.4 -0.4
Body mass index (BMI) 1.0 4.5 6.9 -2.5 -2.5 2.6 -0.4 -1.8 0.9 -2.2 -2.1 -2.6 -1.9 -2.3
Impedance of leg (left) 0.3 1.6 4.2 1.4 1.1 -1.7 1.9 0.2 -2.0 0.7 0.8 0.8 0.9 0.9
Leg predicted mass (left) 0.6 3.0 4.1 -2.0 -1.9 1.9 -1.9 -1.4 0.4 -1.7 -1.7 -1.9 -1.5 -1.9
Trunk fat mass 1.1 4.7 8.1 -2.7 -2.6 2.3 -0.0 -2.2 0.3 -2.3 -2.2 -2.8 -2.1 -2.3
Waist circumference 1.5 5.5 9.0 -2.5 -2.8 1.8 -1.4 -2.3 0.3 -2.6 -2.5 -3.0 -2.5 -2.6
Number of incorrect matches in round 1.3 2.2 4.7 2.2 1.6 -1.2 0.8 1.3 -0.9 1.4 1.5 1.5 1.7 1.8
Past tobacco smoking 0.6 1.1 7.6 0.2 0.5 -0.2 2.8 0.7 0.1 0.6 0.7 1.1 1.4 -0.1
Alcohol usually taken with meals 0.2 0.3 1.3 -0.6 -0.5 1.1 0.3 -0.5 -0.6 -0.5 -0.6 -0.4 -0.5 -0.3
Nervous feelings 0.5 0.9 4.2 -0.3 -0.9 0.3 0.5 -0.9 -2.0 -1.0 -0.8 -1.1 -0.5 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.7 0.1 -1.1 -0.4 0.1 -0.7 0.0 -1.1 -1.1 -0.6 -1.3 -0.8
Hearing difficulty/problems with background noise 0.3 0.5 1.3 -0.1 -0.7 -1.1 -0.6 -0.7 0.4 -0.7 -0.7 -0.5 -1.1 -0.3
Hair/balding pattern: Pattern 2 0.7 0.9 1.9 1.4 0.7 0.4 0.1 1.0 1.4 0.9 0.9 0.7 0.8 1.0
Had menopause 0.5 0.6 3.2 1.2 0.6 -1.1 0.2 0.3 -1.8 0.3 0.4 0.5 0.5 0.2
Had other major operations 0.7 0.9 1.8 -1.3 -0.8 -0.3 -1.0 -0.8 0.3 -0.9 -1.0 -0.9 -1.1 -1.4
Forced vital capacity (FVC) 0.1 0.3 1.2 0.5 0.3 -1.1 -0.6 0.0 -0.4 0.2 0.2 0.5 0.1 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 4.1 -0.4 -0.5 0.5 2.0 0.3 0.3 -0.5 -0.5 -0.4 -0.2 -0.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.1 -0.0 -0.7 -0.5 0.7 -0.4 0.0 -0.6 -0.6 -0.3 -0.6 -1.1
Qualifications: None of the above 0.2 0.3 1.7 1.0 0.1 -1.3 0.4 0.5 -0.6 0.0 -0.0 0.4 0.2 0.2
Financial difficulties in last 2 years 1.1 1.5 3.3 -1.3 -1.3 1.5 0.3 -1.2 -0.1 -1.3 -1.1 -1.8 -1.4 -1.1
Mouth/teeth dental problems 1.3 2.0 5.6 0.4 1.5 1.6 1.0 1.4 0.2 1.5 1.5 1.5 2.4 1.2
Heart attack 0.2 0.2 1.3 -0.1 0.3 -0.4 -1.1 0.0 -0.7 0.2 0.3 0.1 -0.1 0.3
Allergy 0.5 1.2 6.0 -1.6 0.2 1.9 2.4 0.2 0.7 0.3 0.2 0.1 0.4 0.1
Pain all over the body in last month 0.6 0.6 4.2 -1.0 -0.2 0.8 2.1 -0.1 0.8 -0.0 -0.1 -0.4 -0.1 -0.4
Diabetes (self-reported) 0.7 1.0 3.5 0.2 -0.9 0.5 -1.9 -1.2 -0.8 -1.0 -1.0 -1.0 -0.8 -0.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.3 0.4 -0.9 -0.5 -0.7 -0.9 -1.1 -1.0 -0.8 -0.8 -0.8 -0.9
Medication: Ramipril 0.4 0.5 2.2 1.5 0.3 -1.4 0.0 0.1 -1.1 0.1 0.1 0.5 0.2 0.3
Medication: Simvastatin 0.3 0.4 0.8 -0.4 -0.5 0.6 -0.9 -0.7 -0.6 -0.7 -0.7 -0.9 -0.3 -0.5
Fluid intelligence score 0.2 0.3 0.8 -0.9 -0.3 0.9 0.7 -0.4 0.7 -0.3 -0.4 -0.6 -0.4 0.1
Illnesses of siblings 0.6 0.9 2.3 -0.6 -1.0 -0.5 -1.5 -0.6 0.8 -1.0 -1.1 -0.9 -1.3 -0.4
Neuroticism score 0.1 0.3 2.2 0.6 -0.2 -0.4 0.3 -0.0 -1.5 -0.4 -0.4 -0.0 -0.1 -0.4
Weight 1.2 5.9 9.5 -2.9 -2.9 2.4 -0.9 -2.4 0.1 -2.7 -2.5 -3.1 -2.2 -2.9
Impedance of arm (right) 0.2 0.9 3.6 0.6 0.8 -1.1 1.5 -0.1 -1.9 0.5 0.6 0.6 0.6 0.6
Arm fat percentage (right) 1.2 4.7 7.7 -2.7 -2.5 2.4 0.2 -2.1 0.3 -2.3 -2.1 -2.8 -2.0 -2.4
Trunk fat-free mass 0.2 1.2 3.8 -0.7 -1.1 0.8 -2.0 -0.8 -0.1 -1.1 -1.0 -1.1 -0.7 -1.3
Hip circumference 1.1 4.7 7.6 -2.5 -2.6 1.7 -0.5 -2.1 -0.3 -2.5 -2.4 -2.7 -2.0 -2.8
Time employed in main current job 2.4 2.8 7.8 -1.0 -1.4 0.2 -0.9 -2.2 -2.8 -1.7 -1.7 -1.5 -1.4 -2.0
Alcohol intake versus 10 years previously 1.2 1.8 4.5 0.8 1.4 -0.6 0.2 2.1 1.4 1.5 1.4 1.6 1.4 1.4
Father’s age at death 0.6 0.8 2.8 -0.2 -0.9 -0.0 -0.4 -1.0 -1.7 -1.0 -1.0 -0.4 -0.6 -1.2
Worrier / anxious feelings 1.0 1.9 10.7 0.9 -0.4 -2.5 -0.6 -0.5 -3.3 -0.9 -0.8 -0.1 -0.6 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 3.2 -0.7 -0.4 1.1 1.8 -0.1 0.7 -0.3 -0.3 -0.4 -0.3 -0.8
Falls in the last year 4.3 5.8 8.7 -2.3 -2.9 0.9 1.0 -2.8 -0.2 -2.8 -2.8 -2.9 -2.9 -2.9
Hair/balding pattern: Pattern 3 0.6 0.8 1.4 -1.1 -0.9 -0.4 -0.4 -1.1 -0.1 -1.0 -1.2 -1.0 -1.2 -0.9
Number of live births 0.5 0.7 4.8 -1.2 -0.5 0.4 0.7 0.4 2.2 -0.1 -0.2 -0.2 -0.5 -0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 1.1 0.7 -0.0 -1.0 -0.1 0.4 -0.0 -0.1 -0.1 0.5 -0.2 0.5
Pulse rate 2.7 4.6 10.3 -0.6 2.2 3.2 1.6 2.1 2.3 2.5 2.3 1.4 2.0 2.4
Happiness 0.7 0.8 1.9 -1.2 -0.9 0.6 1.4 -0.6 -0.5 -0.9 -0.9 -0.5 -0.5 -1.2
Noisy workplace 0.6 0.7 1.8 0.8 -0.7 -1.4 0.9 -0.5 -0.6 -0.8 -0.8 -0.5 -1.3 -0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 -0.5 0.4 -0.0 0.1 0.4 0.4 0.5 0.5 0.7 0.2 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.4 -0.7 -1.0 0.6 0.8 -1.2 -1.0 -1.1 -1.1 -1.1 -0.7 -0.9
Mouth/teeth dental problems: Dentures 0.9 1.5 4.1 -0.2 -1.3 -1.6 -1.1 -1.1 -0.4 -1.3 -1.3 -1.5 -2.0 -0.8
Asthma 0.7 1.4 3.1 1.8 1.1 -1.4 -1.3 1.2 -0.0 1.1 1.3 1.1 1.1 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.8 -0.3 0.5 -0.4 0.7 0.9 0.7 0.4 0.3 0.5 -0.2 0.6
Medication: Cholesterol lowering 0.3 0.5 2.8 0.6 0.6 0.8 -1.7 0.1 -0.6 0.5 0.5 0.3 0.7 0.4
Depression (self-reported) 2.1 2.5 4.6 -1.1 -1.8 1.3 -0.3 -1.9 -1.1 -1.9 -1.8 -2.1 -1.1 -2.2
Medication: Lansoprazole 0.2 0.2 0.5 0.2 0.5 -0.1 -0.1 0.7 0.4 0.5 0.5 0.6 0.4 0.4
Prospective memory result 1.5 1.8 6.2 1.9 1.0 -2.0 -1.0 0.4 -2.5 0.6 0.8 0.8 1.3 0.6
Lung cancer (father) 2.6 3.0 4.3 1.3 1.9 -0.3 1.4 2.0 1.7 2.1 2.1 1.8 1.8 2.0
Illnesses of mother 0.5 0.6 1.7 -0.3 0.6 1.3 -0.5 0.3 1.2 0.7 0.7 0.0 0.9 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.9 0.7 -0.6 -0.9 -0.1 -0.4 -0.6 -0.7 -0.8 0.0 -0.5 -0.3
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 -1.5 -1.0 0.4 0.4 -0.2 1.4 -0.7 -0.8 -0.7 -1.1 -0.6
Impedance of arm (left) 0.3 1.2 4.1 0.9 1.1 -1.2 1.4 -0.0 -2.0 0.7 0.8 0.9 0.8 0.9
Arm fat mass (right) 1.2 4.9 8.1 -2.6 -2.7 2.4 -0.3 -2.2 0.1 -2.4 -2.3 -2.8 -2.1 -2.6
Trunk predicted mass 0.2 1.2 4.0 -0.8 -1.2 0.9 -2.0 -0.9 -0.2 -1.1 -1.0 -1.2 -0.8 -1.3
Standing height 0.1 1.1 3.0 -0.9 -0.9 -0.2 -0.9 -1.3 -1.7 -1.1 -1.0 -1.1 -0.7 -1.1
Length of working week for main job 0.6 0.7 3.9 -1.3 0.0 2.0 -0.5 0.3 1.3 0.2 0.2 0.1 -0.2 -0.1
Exposure to tobacco smoke at home 0.2 0.2 1.2 -0.5 0.3 1.1 0.4 0.1 0.2 0.3 0.3 0.1 0.5 0.1
Breastfed as a baby 0.3 0.3 2.2 -0.0 0.6 0.3 -0.2 -0.2 -1.5 0.3 0.4 0.1 0.7 0.2
Tense / ‘highly strung’ 0.5 0.8 1.3 0.9 0.9 -0.2 1.1 1.1 -1.0 0.7 0.7 0.9 1.1 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.8 -0.8 -1.2 -0.4 -0.8 -0.4 -0.0 -1.1 -1.2 -0.6 -1.3 -1.4
Hair/balding pattern: Pattern 4 0.4 1.0 2.2 0.5 1.1 -0.5 -1.3 1.1 -0.5 1.1 1.1 1.5 1.1 0.7
Birth weight of first child 1.4 2.6 4.6 -1.4 -2.1 -0.5 0.3 -1.4 -0.2 -2.1 -2.1 -1.9 -1.9 -1.7
Peak expiratory flow (PEF) 0.5 1.2 2.3 -0.9 -1.3 0.5 0.1 -0.9 -0.9 -1.4 -1.5 -0.9 -1.3 -1.3
Pulse wave reflection index 1.4 1.7 2.8 -1.3 -1.6 -1.1 0.0 -1.4 0.1 -1.4 -1.4 -1.2 -1.7 -1.7
Ever highly irritable/argumentative for 2 days 1.6 2.0 3.0 -1.5 -1.7 1.4 1.1 -1.1 0.4 -1.5 -1.4 -1.4 -1.5 -1.7
Loud music exposure frequency 1.6 1.7 3.2 -0.8 -1.6 1.0 -0.3 -1.6 0.3 -1.5 -1.5 -1.8 -1.5 -1.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 2.0 -1.4 -0.5 1.0 -0.6 -0.3 0.3 -0.3 -0.3 -0.1 -0.4 -0.7
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.5 -0.5 -0.5 0.6 0.4 -0.2 0.7 -0.4 -0.4 -0.1 -0.6 -0.6
Blood clot in the leg (DVT) 0.6 0.7 1.5 1.2 0.5 -1.2 -1.0 0.8 1.2 0.6 0.5 0.8 0.4 0.7
Medication: Paracetamol 2.2 3.6 8.8 -1.7 -2.3 -1.5 -0.3 -1.5 0.7 -2.2 -2.4 -1.8 -3.0 -1.9
Headache pain in last month 0.4 0.7 4.1 0.7 0.1 -2.0 -1.0 0.9 0.6 0.2 0.2 0.7 -0.6 0.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 2.4 -0.1 0.2 -0.4 1.5 0.6 1.0 0.3 0.3 0.6 0.2 0.1
Glaucoma (self-reported) 0.4 0.5 2.2 -0.6 0.6 1.5 0.2 0.3 0.7 0.7 0.6 0.2 0.6 0.8
Gout (self-reported) 0.2 0.2 1.4 0.3 0.4 0.3 0.5 -0.0 -1.2 0.2 0.2 -0.2 0.5 0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 3.2 -0.1 -0.2 -1.8 0.2 -0.5 -0.4 -0.4 -0.4 -0.8 -0.4 -0.2
Medication: Amlodipine 0.7 0.9 4.2 1.3 0.2 -2.0 -1.8 -0.2 -0.9 0.0 0.1 0.3 -0.3 0.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.6 -0.2 -0.6 -1.2 -1.3 -0.1 0.1 -0.5 -0.4 -0.3 -0.5 -0.6
Birth weight 0.5 1.0 6.6 0.7 -0.1 -1.9 -2.6 0.0 0.4 -0.0 -0.0 -0.0 -0.5 0.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.1 -0.2 -1.1 -0.3 -1.2 -0.5 0.8 -0.9 -1.0 -1.0 -1.4 -0.6
High blood pressure (siblings) 0.5 0.8 4.5 -0.5 0.1 1.1 0.8 -0.8 -2.1 -0.2 -0.1 -0.5 0.4 -0.8
Forced vital capacity (FVC), Best measure 0.1 0.4 1.1 0.6 -0.4 -1.0 -0.7 -0.8 -1.0 -0.6 -0.7 -0.1 -0.3 -0.2
Body fat percentage 1.2 4.6 8.0 -2.8 -2.5 2.3 0.5 -2.1 0.4 -2.2 -2.1 -2.8 -2.0 -2.2
Leg fat percentage (right) 1.6 5.7 9.7 -3.1 -2.8 2.2 0.9 -2.3 0.8 -2.5 -2.4 -3.1 -2.4 -2.5
Arm fat-free mass (right) 0.4 1.8 3.1 -1.3 -1.5 1.5 -1.8 -1.1 -0.0 -1.4 -1.3 -1.6 -1.1 -1.6
Exposure to tobacco smoke outside home 6.3 8.4 14.7 -2.4 -3.5 1.1 -0.2 -3.1 -1.2 -3.6 -3.7 -3.1 -3.4 -3.8
Comparative body size at age 10 0.4 1.1 5.5 1.7 0.2 -1.8 -2.3 -0.2 -0.8 0.1 0.1 0.4 0.3 0.1
Number of full brothers 0.5 0.6 2.1 1.5 0.5 -1.0 -0.5 0.7 -0.4 0.5 0.5 1.1 0.6 0.3
Worry too long after embarrassment 0.9 1.5 3.8 1.0 1.2 0.5 1.9 1.7 0.4 1.2 1.1 1.2 1.1 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 0.1 -0.2 -0.6 0.1 0.2 0.3 -0.2 -0.2 -0.0 -0.2 -0.7
Wheeze or whistling in the chest in last year 0.4 0.7 2.3 -0.4 -0.8 0.2 -1.5 -0.1 0.8 -0.7 -0.7 -0.3 -1.2 -0.9
Number of children fathered 0.9 1.0 3.4 -1.5 -0.5 1.6 1.3 0.4 1.8 -0.2 -0.4 -0.5 -0.2 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.1 0.3 1.5 0.5 0.5 1.4 0.9 1.5 1.4 1.4 1.8 1.3
Age at first live birth 0.4 0.7 3.1 1.0 0.4 -1.8 -0.0 0.9 0.0 0.3 0.2 1.3 0.1 0.6
Pulse wave peak to peak time 0.7 0.8 3.1 1.3 0.9 -0.2 -0.4 0.1 -1.8 0.6 0.8 0.6 1.1 0.5
Health satisfaction 1.3 1.6 3.3 -0.2 -1.5 0.2 -0.5 -1.8 -0.8 -1.5 -1.5 -1.5 -1.5 -1.6
Shortness of breath walking on level ground 1.1 1.3 2.9 0.4 -1.5 -0.5 -1.0 -0.9 -0.4 -1.5 -1.5 -0.8 -1.7 -1.3
Qualifications: College or University degree 0.2 0.6 1.5 0.6 1.0 0.0 0.8 0.3 -1.2 0.8 0.9 0.5 0.9 1.0
Eye problems/disorders: None of the above 0.2 0.2 1.6 0.0 0.2 -0.2 1.3 0.5 0.4 0.3 0.3 0.4 0.1 0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.7 -0.5 0.0 1.3 1.3 0.1 0.1 0.1 0.1 -0.2 0.3 -0.1
Emphysema/chronic bronchitis 2.8 3.2 5.0 -1.4 -2.1 0.8 -1.7 -1.9 -0.5 -2.1 -2.1 -1.8 -2.2 -2.1
Medication for pain relief, constipation, heartburn 1.4 2.3 4.8 1.0 1.7 1.2 0.2 1.4 0.8 1.9 2.0 1.4 2.2 1.8
Neck or shoulder pain in last month 0.1 0.1 0.6 -0.4 0.4 -0.1 0.8 0.0 -0.2 0.3 0.3 -0.2 0.3 0.3
Medication: Blood pressure 0.3 0.5 2.5 0.8 0.6 -0.6 -1.6 0.5 -0.2 0.5 0.5 0.5 0.2 0.9
Angina (self-reported) 0.2 0.2 1.7 -0.4 0.2 1.3 0.1 -0.4 -0.1 0.2 0.2 -0.1 0.4 -0.3
Migraine (self-reported) 0.1 0.1 0.4 -0.6 0.2 -0.4 0.3 0.4 -0.2 0.2 0.2 0.5 0.1 -0.5
Medication: Ibuprofen 0.1 0.1 0.5 -0.7 0.1 -0.1 0.6 0.3 0.0 -0.0 -0.1 -0.1 -0.4 0.1
Medication: Allopurinol 0.5 0.7 1.3 0.3 1.1 -0.2 1.0 0.3 -1.1 0.8 0.8 0.4 1.1 0.9
Medication: Omeprazole 0.3 0.3 2.4 -0.1 0.3 0.3 0.5 -0.5 -1.5 0.0 0.1 -0.4 0.3 0.1
Medication: Seretide 50 evohaler 2.4 2.7 4.5 -0.5 -1.9 -1.5 0.0 -1.8 -1.6 -2.1 -2.0 -1.6 -1.9 -1.9
Mean time to correctly identify matches 0.2 0.3 2.2 0.1 -0.1 0.9 -1.5 -0.1 -0.3 -0.0 0.1 -0.3 0.3 -0.6
Heart disease (mother) 0.4 0.5 1.5 0.7 1.1 -0.2 -0.4 0.5 -0.4 1.0 0.9 1.2 0.7 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 2.5 1.1 1.1 -0.0 0.5 1.6 -0.1 1.1 1.1 1.6 0.9 0.6
Whole body fat mass 1.0 4.4 7.7 -2.7 -2.4 2.4 -0.2 -2.1 0.2 -2.2 -2.0 -2.8 -1.9 -2.2
Leg fat mass (right) 1.6 6.3 10.7 -3.3 -2.9 2.6 -0.2 -2.4 0.8 -2.6 -2.5 -3.3 -2.4 -2.7
Arm predicted mass (right) 0.2 1.2 2.3 -1.0 -1.2 1.3 -1.5 -0.8 0.3 -1.1 -1.0 -1.3 -0.8 -1.3
Pulse rate, automated reading 1.7 5.5 22.7 -2.6 0.9 4.8 0.7 1.1 4.7 1.5 1.3 0.1 0.7 1.4
Alcohol intake frequency. 0.1 0.3 1.5 -0.4 -0.1 1.2 0.9 0.2 0.4 0.1 0.2 -0.3 0.3 -0.1
Comparative height size at age 10 0.2 0.9 2.1 -1.5 -1.2 -0.1 -0.5 -0.6 -0.4 -1.1 -1.0 -1.1 -0.8 -1.3
Number of full sisters 0.5 0.6 3.6 -0.5 -0.6 -0.3 -1.9 -0.1 -0.0 -0.6 -0.7 -0.5 -0.7 -0.7
Suffer from ‘nerves’ 0.2 0.3 1.5 0.4 -0.6 -1.2 0.5 0.3 0.6 -0.4 -0.4 -0.2 -0.4 -0.2
Overall health rating 0.2 0.5 1.1 -0.7 -0.8 0.7 0.5 -0.8 -0.0 -0.7 -0.7 -0.7 -0.8 -1.0
Chest pain or discomfort 0.1 0.2 0.8 -0.2 -0.5 -0.1 0.7 -0.3 0.9 -0.3 -0.3 -0.2 -0.7 -0.3
Had major operations 0.4 0.5 1.6 -0.9 -0.7 -0.4 0.6 -0.1 0.4 -0.7 -0.7 -0.3 -1.3 -0.7
Age at last live birth 0.3 0.4 1.3 0.1 0.3 -1.1 -0.4 0.8 0.9 0.5 0.4 1.1 0.2 0.4
Family relationship satisfaction 0.7 0.9 2.1 -0.1 -1.1 -0.5 0.6 -0.9 -1.4 -1.2 -1.1 -0.6 -0.7 -1.2
Leg pain on walking 0.5 0.6 3.7 1.1 -0.4 -1.9 -0.2 -0.3 -0.6 -0.5 -0.4 -0.5 -0.4 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.8 -1.2 -1.3 0.4 -0.3 -0.6 0.7 -1.1 -1.1 -1.1 -1.3 -1.0
Commuting to job workplace: Car/motor vehicle 4.0 4.6 7.0 -1.7 -2.6 0.7 -1.1 -2.5 -0.4 -2.6 -2.6 -2.5 -2.4 -2.6
Illness, injury, bereavement, stress in last 2 years 2.4 3.0 5.1 1.5 2.2 -0.8 -0.3 1.6 -0.4 2.1 2.1 2.2 2.2 1.9
Medication: Aspirin 1.0 1.3 2.6 -0.6 -1.1 0.2 -0.8 -1.5 -1.6 -1.2 -1.2 -1.1 -1.1 -1.5
Supplements: Vitamin C 1.1 1.3 3.3 1.8 1.2 -1.8 -0.6 0.7 0.0 1.0 1.0 1.1 0.6 1.3
Knee pain experienced in last month 1.3 2.1 3.3 -1.6 -1.7 1.6 -0.2 -1.3 1.4 -1.4 -1.5 -1.8 -1.6 -1.2
Hypertension (Self-reported) 0.1 0.3 1.4 0.5 0.5 -0.6 -0.4 0.5 -1.2 0.3 0.5 0.4 0.4 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.8 0.4 0.1 -1.3 -1.1 -0.2 -0.8 -0.1 -0.0 0.5 0.1 -0.2
Illnesses of father: Heart disease 0.6 0.9 3.5 -0.5 -0.3 1.9 0.5 -0.4 -1.8 -0.5 -0.4 -0.6 0.8 -0.9
Illnesses of siblings: Diabetes 1.3 1.6 3.3 -0.6 -1.7 -0.5 -0.3 -1.1 -0.2 -1.6 -1.5 -1.2 -1.8 -1.7
Smoking status: Previous 0.7 1.1 4.2 -0.5 -0.7 0.2 -2.1 -1.0 -0.8 -0.9 -0.9 -1.4 -1.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 3.8 -0.9 -1.8 0.4 0.3 -1.9 -1.8 -1.9 -1.9 -1.5 -1.2 -2.0
Whole body fat-free mass 0.4 2.1 4.1 -1.4 -1.6 1.3 -2.0 -1.2 0.0 -1.5 -1.4 -1.6 -1.1 -1.7
Leg fat-free mass (right) 0.5 2.7 4.5 -1.7 -1.9 1.6 -2.1 -1.3 0.1 -1.7 -1.7 -1.8 -1.4 -1.9
Arm fat percentage (left) 1.0 3.9 6.5 -2.5 -2.3 2.4 0.2 -1.9 0.4 -2.0 -1.9 -2.5 -1.8 -2.1
Average weekly red wine intake 0.4 0.6 5.0 -0.5 -0.0 2.2 0.9 -0.0 -0.9 -0.1 0.0 -0.4 0.1 0.2
Handedness (chirality/laterality): Left-handed 0.5 0.5 1.7 -1.3 -0.9 -0.5 -0.4 -0.3 0.4 -0.8 -0.7 -0.8 -0.6 -0.9
Mood swings 0.9 1.6 3.0 -0.9 -1.5 -0.5 -1.1 -1.3 -0.4 -1.5 -1.5 -1.4 -1.4 -1.7
Loneliness, isolation 1.9 2.6 4.8 2.1 1.8 -0.3 -0.8 1.7 0.0 1.8 1.8 2.2 1.8 1.5
Long-standing illness, disability or infirmity 0.8 1.2 2.3 -1.3 -1.1 -0.3 -0.7 -1.3 -0.6 -1.2 -1.2 -1.5 -1.3 -1.2
Ever had bowel cancer screening 0.4 0.4 2.7 -0.7 -0.1 0.9 1.6 0.1 0.7 0.1 0.1 0.0 0.2 -0.2
Diabetes diagnosed by doctor 1.5 2.4 3.8 -0.5 -1.7 1.0 -1.8 -1.9 -0.9 -1.8 -1.7 -1.9 -1.4 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.7 -0.2 -0.2 0.3 0.7 0.1 0.8 -0.0 -0.0 -0.2 -0.0 0.0
Friendships satisfaction 0.4 0.5 4.1 -0.2 -0.1 0.1 2.0 -0.3 -0.9 -0.2 -0.1 0.2 0.3 -0.7
Qualifications: nursing, teaching 1.2 1.8 5.0 -2.2 -1.5 0.5 0.5 -1.2 0.8 -1.4 -1.4 -1.3 -1.5 -1.3
Commuting to job workplace: Walk 5.2 5.6 9.1 2.2 3.0 -0.2 -0.8 2.7 0.0 2.9 2.9 2.7 3.0 2.5
Eye problems/disorders: Cataract 0.1 0.1 0.3 -0.3 -0.4 -0.2 -0.5 -0.3 0.2 -0.4 -0.4 -0.3 -0.4 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 2.6 0.3 -0.5 -1.6 0.2 0.0 1.1 -0.4 -0.5 0.2 -1.3 -0.2
Medication for cholesterol 0.3 0.4 2.8 0.2 0.1 -0.1 -0.7 0.7 1.7 0.4 0.3 0.3 -0.2 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.8 3.2 6.2 -1.3 -2.3 -0.2 -0.3 -1.8 -0.3 -2.3 -2.3 -1.6 -2.4 -2.5
Back pain experienced in last month 0.2 0.3 1.7 -0.6 0.1 -0.7 0.7 0.8 1.3 0.2 0.1 0.2 -0.1 0.2
Mineral and other dietary supplements 1.4 1.8 3.8 -0.9 -1.5 -0.9 -1.9 -1.4 0.5 -1.4 -1.5 -1.0 -1.7 -1.4
Breast cancer (self-reported) 0.6 0.7 1.3 -0.7 -0.9 0.5 -0.2 -1.0 -0.0 -1.0 -1.1 -1.0 -1.0 -0.9
Asthma (self-reported) 0.5 1.1 2.8 1.7 1.0 -1.0 -1.1 1.0 -0.1 1.0 1.1 0.9 1.0 0.9
Osteoporosis (self-reported) 0.9 1.2 3.1 -0.2 -1.2 -0.8 -1.8 -0.6 0.6 -1.1 -1.1 -1.0 -1.7 -0.6
Osteoarthritis (self-reported) 0.7 0.9 1.6 0.1 1.1 -1.0 1.3 1.2 0.7 1.1 1.0 0.9 0.7 1.1
Medication: Aspirin 0.6 0.7 1.5 -0.5 -0.7 0.1 -0.9 -1.2 -1.2 -0.8 -0.8 -0.9 -0.8 -0.9
Medication: Gliclazide 7.0 8.0 12.5 -2.3 -3.2 1.4 -2.7 -3.4 -0.1 -3.1 -3.2 -3.5 -3.1 -3.0
Illnesses of father: None of the above (group 1) 1.5 1.9 6.1 0.7 1.0 -1.7 0.8 1.5 2.5 1.3 1.2 1.5 0.2 1.5
Smoking status: Current 0.4 0.7 3.6 -0.4 -0.4 0.4 -1.7 -0.2 1.9 -0.1 -0.2 -0.4 -0.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 4.2 -0.6 -0.9 -0.8 2.0 -0.7 -0.7 -1.1 -1.3 -0.4 -1.0 -0.9
Whole body water mass 0.3 1.9 3.3 -1.3 -1.6 1.4 -1.8 -1.1 0.1 -1.4 -1.3 -1.5 -1.1 -1.7
Leg predicted mass (right) 0.5 2.5 4.4 -1.7 -1.8 1.6 -2.1 -1.3 0.2 -1.6 -1.6 -1.7 -1.4 -1.8
Arm fat mass (left) 1.1 4.3 7.1 -2.5 -2.4 2.6 -0.1 -2.0 0.3 -2.1 -2.0 -2.7 -1.8 -2.3
Number of self-reported non-cancer illnesses 0.8 1.4 6.7 1.5 0.3 -1.6 -1.8 -0.4 -2.6 -0.1 0.0 0.1 0.4 -0.3
Average weekly champagne plus white wine intake 0.2 0.2 0.7 -0.3 -0.3 0.4 0.1 -0.7 -0.8 -0.4 -0.5 -0.0 -0.4 -0.4
Miserableness 0.5 0.8 3.6 0.2 -0.7 -1.0 -1.9 -0.6 -0.8 -0.8 -0.7 -0.6 -0.7 -0.7
Guilty feelings 0.1 0.2 0.5 0.2 -0.3 0.4 -0.7 0.1 -0.5 -0.4 -0.5 -0.1 -0.4 -0.4
Wears glasses or contact lenses 0.9 1.1 2.5 1.2 0.6 -1.0 -1.6 1.3 0.7 0.8 0.9 1.4 0.5 0.6
Ever taken oral contraceptive pill 0.9 1.1 2.3 -1.5 -1.0 0.8 0.1 -0.9 -0.9 -1.1 -1.1 -1.1 -0.8 -1.3
Hearing aid user 0.4 0.5 3.0 0.2 0.3 0.6 1.1 -0.4 -1.7 -0.1 -0.1 -0.1 0.2 -0.2
Mother’s age at death 1.8 2.3 4.7 1.2 1.8 -1.2 0.1 1.7 0.6 1.7 1.6 2.2 1.4 2.0
Financial situation satisfaction 1.9 2.3 4.0 -2.0 -1.7 0.7 1.7 -1.6 -0.3 -1.6 -1.6 -1.5 -1.4 -1.7
Tinnitus: Yes, now most or all of the time 2.4 2.8 5.3 -0.8 -1.7 -1.5 -1.2 -2.0 -1.5 -1.9 -1.8 -1.8 -2.3 -1.5
Commuting to job workplace: Public transport 1.3 1.5 6.9 0.8 0.8 -1.9 -2.6 0.9 0.2 0.8 0.9 1.1 0.2 1.3
Eye problems/disorders: Glaucoma 1.3 1.6 2.7 0.5 1.6 1.5 0.0 1.1 1.0 1.6 1.5 1.1 1.5 1.4
Medication: Blood pressure 0.1 0.3 1.5 -0.1 -0.2 -0.2 0.6 -0.6 -1.2 -0.4 -0.3 -0.5 -0.2 -0.4
Pain type(s) experienced in last month: Hip pain 0.5 0.7 3.1 -0.6 -0.7 0.3 -1.8 -0.3 1.1 -0.6 -0.6 -1.0 -0.8 -0.1
Supplements: Fish oil (including cod liver oil) 1.6 2.1 3.6 1.3 1.7 0.1 1.7 1.6 -0.6 1.6 1.6 1.4 1.9 1.5
High cholesterol (Self-reported) 0.6 1.1 3.1 1.2 1.3 0.3 0.1 0.9 -0.9 1.0 1.0 0.8 1.8 1.0
Medication: Bendroflumethiazide 0.5 0.7 3.3 0.9 0.7 -1.3 -0.6 0.3 -1.8 0.4 0.5 0.3 0.3 0.7
Medication: Paracetamol 1.5 2.3 5.4 -1.5 -1.6 -1.5 -0.7 -1.0 0.6 -1.6 -1.9 -1.4 -2.3 -1.5
Medication: Lisinopril 0.2 0.2 0.6 -0.2 0.5 0.7 -0.8 0.1 -0.3 0.5 0.5 0.0 0.7 0.3
Medication: Atorvastatin 1.0 1.2 5.9 -0.6 -0.6 1.2 0.9 -0.9 -2.4 -0.9 -0.8 -1.0 -0.4 -0.8
Illnesses of father: High blood pressure 0.7 0.9 3.7 1.8 0.6 -1.1 0.4 0.3 -1.9 0.3 0.5 0.7 0.6 0.5
Alcohol drinker status: Never 1.1 1.3 3.2 -0.1 -1.1 1.0 0.8 -1.0 -1.5 -1.2 -1.2 -1.1 -0.6 -1.8
Ever smoked 0.4 0.8 6.4 0.1 -0.2 0.3 -2.5 -0.5 0.2 -0.3 -0.4 -0.7 -1.0 0.2
Basal metabolic rate 0.5 2.8 4.1 -1.7 -1.9 1.5 -1.8 -1.5 -0.0 -1.8 -1.7 -2.0 -1.4 -2.0
Leg fat percentage (left) 1.3 4.6 8.2 -2.6 -2.6 1.9 0.6 -2.0 0.6 -2.4 -2.2 -2.9 -2.2 -2.3
Arm fat-free mass (left) 0.4 2.1 3.5 -1.3 -1.7 1.3 -1.9 -1.2 0.0 -1.5 -1.5 -1.7 -1.2 -1.8
Number of operations (self-reported) 1.1 1.6 3.6 -1.4 -1.4 0.7 0.8 -1.0 -0.2 -1.4 -1.5 -1.3 -1.5 -1.9
Average weekly beer plus cider intake 0.9 1.4 4.6 1.9 0.9 -2.1 -0.7 0.9 0.8 0.9 0.8 0.9 0.7 1.2
Irritability 0.6 1.0 8.0 1.0 0.2 -1.1 -1.0 -0.3 -2.8 -0.2 -0.0 0.1 -0.0 -0.2
Risk taking 0.4 0.6 1.7 1.2 0.6 0.1 0.1 1.3 0.4 0.6 0.5 1.3 0.9 0.8
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.0 -1.0 -0.4 0.9 -0.7 -0.2 0.3 -0.3 -0.4 -0.1 -0.6 -0.3
Fractured/broken bones in last 5 years 0.2 0.3 1.0 0.7 0.1 1.0 -0.0 0.1 0.8 0.3 0.4 0.5 0.5 0.2
Age started oral contraceptive pill 0.9 1.1 1.7 0.9 1.3 -1.1 1.0 1.1 -0.3 1.1 1.0 1.2 1.2 0.9
Diastolic blood pressure, automated reading 1.8 5.5 15.4 -3.8 -2.2 3.9 1.1 -1.5 1.3 -1.8 -1.8 -2.5 -1.8 -2.2
Ever depressed for a whole week 0.4 0.5 1.7 0.6 -0.8 0.1 0.2 -0.7 -0.9 -0.8 -0.8 -0.3 -0.4 -1.3
Unable to work because of sickness or disability 2.1 2.8 5.0 -1.8 -1.8 0.9 -0.5 -1.8 -1.2 -1.8 -1.8 -2.2 -1.6 -2.0
Commuting to job workplace: Cycle 0.6 0.7 3.4 0.7 0.6 -1.8 1.2 0.8 0.2 0.5 0.4 0.6 0.4 0.8
Myopia 0.4 0.5 1.7 -1.2 -0.2 0.5 1.3 0.7 1.2 0.0 -0.1 0.3 0.1 -0.3
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.6 -0.2 -0.4 0.8 0.7 -0.1 0.8 -0.3 -0.5 -0.2 -0.1 -0.4
Cholesterol lowering medication 0.6 0.9 4.0 -0.4 -0.7 0.6 0.4 -1.0 -2.0 -1.0 -0.9 -1.3 -0.3 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 2.2 0.3 0.5 0.4 -0.3 -0.2 -1.5 0.3 0.3 -0.0 0.6 0.2
Pain experienced in last month 0.3 0.5 1.5 1.2 0.6 -0.2 1.2 0.4 -0.3 0.5 0.6 0.6 0.8 0.6
Supplements: Calcium 0.4 0.5 1.2 -0.5 -0.5 0.5 -1.1 -0.5 -0.8 -0.7 -0.8 -1.0 -0.3 -0.7
Basal cell carcinoma (self-reported) 0.6 0.7 1.3 -0.2 -1.0 1.0 1.1 -0.7 -0.6 -1.1 -1.1 -0.6 -0.5 -0.8
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.5 -0.1 0.4 -0.3 -1.2 -0.0 -0.9 0.3 0.3 0.1 0.1 0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.1 1.3 0.4 -1.4 -1.3 0.7 1.1 0.6 0.5 0.8 0.4 0.5
Heart disease (siblings) 0.5 0.6 1.1 0.6 0.8 0.5 1.1 0.7 -0.6 0.7 0.7 1.0 0.8 0.4
Alcohol drinker status: Previous 0.3 0.4 1.0 -1.0 -0.6 0.3 -0.8 -0.4 0.4 -0.5 -0.4 -0.9 -0.8 -0.5
Pack years of smoking 0.2 0.3 0.9 -0.5 -0.6 -0.1 -0.9 -0.2 0.8 -0.5 -0.6 -0.6 -0.6 -0.2
Impedance of whole body 0.2 1.1 4.4 0.9 0.8 -1.5 1.6 -0.2 -2.1 0.4 0.5 0.5 0.5 0.6
Leg fat mass (left) 1.4 5.5 9.2 -2.9 -2.8 2.4 -0.3 -2.2 0.7 -2.5 -2.4 -3.0 -2.3 -2.5
Arm predicted mass (left) 0.4 2.0 3.3 -1.3 -1.7 1.0 -1.6 -1.2 0.1 -1.6 -1.5 -1.7 -1.2 -1.8