Hub : Genes

THAP8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1210	0.0480	2.2e-03	0.028	NA	0.008	NA	0.001	1.1e-02	NA	1.2e-01	NA	2.8e-01
2	GTEx	Cells Transformed fibroblasts	0.1940	0.0440	4.1e-09	0.202	NA	0.173	NA	0.197	4.0e-15	NA	5.7e-13	NA	1.0e-14
3	GTEx	Skin Sun Exposed Lower leg	0.2560	0.0560	9.9e-07	0.070	NA	0.116	NA	0.078	1.9e-06	NA	8.5e-10	NA	5.1e-07
4	GTEx	Whole Blood	0.0930	0.0380	1.6e-03	0.003	NA	0.029	NA	0.003	1.5e-01	NA	1.1e-03	NA	1.7e-01
5	TCGA	Glioblastoma Multiforme	0.2230	0.0860	4.0e-06	0.240	0.215	0.197	NA	0.209	6.7e-08	3.8e-07	1.2e-06	NA	5.5e-07
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0522	0.0305	2.1e-03	0.005	0.019	0.014	NA	0.013	8.6e-02	2.7e-03	9.3e-03	NA	1.2e-02
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0943	0.0513	2.1e-06	0.065	0.050	0.047	NA	0.058	7.4e-08	2.6e-06	4.8e-06	NA	3.8e-07
8	TCGA	Lung Adenocarcinoma	0.0332	0.0205	7.0e-04	0.044	0.032	0.039	NA	0.042	7.1e-06	1.2e-04	2.3e-05	NA	9.8e-06
9	TCGA	Prostate Adenocarcinoma	0.0310	0.0178	1.9e-03	0.031	0.021	0.020	NA	0.020	3.1e-04	2.8e-03	3.0e-03	NA	3.0e-03
10	TCGA	Stomach Adenocarcinoma	0.0620	0.0350	1.9e-04	0.054	0.054	0.048	NA	0.059	9.0e-05	8.9e-05	2.2e-04	NA	4.1e-05
11	TCGA	Thyroid Carcinoma	0.0550	0.0260	2.8e-05	0.038	0.039	0.042	NA	0.040	1.3e-04	9.6e-05	5.6e-05	NA	8.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.4	0.9	0.2	0.6	0.8	0.1	0.7	1.0	0.6	0.5	0.1	0.9	0.5
Bipolar Disorder or Schizophrenia	0.1	0.1	0.7	0.4	0.3	0.2	-0.2	0.8	-0.3	0.2	0.0	0.1	0.4	0.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.7	0.2	-0.4	-0.7	-1.3	-0.4	-0.9	-0.5	-0.5	-0.2	-0.4	-0.4
Depression (Nagel 2018)	0.7	1.0	2.2	1.5	0.8	-1.3	-0.5	1.1	0.9	0.9	0.9	1.2	0.5	1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.6	-0.5	0.8	1.5	0.7	0.6	1.6	0.9	0.8	0.3	1.1	0.8
Neuroticism (Nagel 2018)	0.3	0.6	3.0	1.1	0.0	-1.7	-0.6	0.3	-1.5	-0.3	-0.3	0.2	-0.3	0.1
Schizophrenia (2018)	0.1	0.2	1.3	0.4	-0.1	-0.5	-0.4	0.5	-1.1	-0.3	-0.3	0.1	-0.2	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.8	0.1	1.0	0.0	1.7	0.9	-0.5	0.9	1.0	1.2	0.5	1.1
Worry (Nagel 2018)	0.4	0.9	5.6	1.2	0.2	-2.4	0.2	0.5	-1.5	-0.1	-0.0	0.3	0.1	0.4
Alzheimer’s Disease (in mother)	5.0	5.9	13.4	-0.2	-2.7	0.2	-0.6	-2.8	-3.7	-3.0	-2.8	-2.3	-2.0	-3.1
Alzheimer’s Disease (in father)	0.4	0.4	1.5	1.2	0.5	-0.5	-1.1	0.5	-0.1	0.5	0.5	0.6	0.3	0.4
Alzheimer’s Disease (including proxy)	3.2	4.6	11.0	0.6	-2.3	-0.9	-1.3	-2.4	-3.3	-2.6	-2.4	-1.8	-1.9	-2.5
Crohns Disease (2017)	0.3	0.7	2.7	1.1	0.0	-1.6	-0.7	-0.2	-1.6	-0.3	-0.4	-0.0	-0.2	-0.3
Irritable Bowel Disease (IBD)	0.7	1.7	7.7	2.0	1.2	-2.8	-1.2	0.7	-1.1	0.8	0.6	1.1	0.5	0.8
Ulcerative Colitis (UC)	0.9	1.7	7.1	1.6	1.4	-2.7	-0.8	0.8	-0.6	1.1	1.0	1.2	0.7	1.1
Major Depression (MDD)	0.7	0.9	2.7	0.5	0.8	1.7	1.2	0.7	-0.2	0.7	0.8	0.8	1.5	-0.0
Reaction Time	0.3	0.6	3.2	-0.3	-0.7	1.0	-1.8	-0.3	-0.2	-0.6	-0.4	-0.8	-0.2	-1.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.1	-0.0	0.2	0.1	1.0	0.1	0.7	0.3	0.2	-0.1	0.0	0.5
Breast Cancer	0.0	0.1	0.6	0.4	0.1	0.5	-0.8	0.0	0.4	0.1	-0.1	0.3	-0.1	-0.0
Ovarian Cancer	1.2	1.6	4.3	-2.1	-1.4	0.6	-1.0	-1.2	0.8	-1.3	-1.3	-1.6	-1.4	-0.8
Prostate Cancer	1.6	2.2	5.2	0.7	1.6	-0.2	1.1	1.5	1.6	1.8	1.9	1.1	1.5	2.3
Age at First Birth	0.3	0.5	2.8	-0.4	0.5	-0.5	1.7	0.2	-0.8	0.3	0.3	0.6	0.5	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.7	0.8	0.4	-0.4	-0.8	0.0	-0.4	0.3	0.3	0.4	0.2	0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.2	0.5	-0.5	0.4	0.6	0.2	0.5	0.5	0.5	0.4	0.4
Crohns Disease (2012)	0.4	0.6	4.9	0.5	-0.1	-0.4	0.3	-0.2	-2.2	-0.5	-0.5	-0.1	0.4	-0.7
Mean Putamen Volume	1.4	1.6	3.5	-1.1	-1.2	1.7	1.5	-1.1	1.9	-0.8	-0.8	-1.5	-0.8	-1.1
Fasting Glucose	2.7	3.2	5.4	-2.3	-2.0	0.9	-1.0	-2.0	-0.5	-2.0	-2.0	-2.2	-1.9	-2.0
HbA1C	0.7	0.8	1.5	-1.2	-1.1	0.0	-0.4	-0.9	0.9	-0.9	-0.9	-1.2	-0.9	-0.9
HDL Cholesterol	0.4	0.7	3.3	-0.4	-0.4	0.6	-0.5	-1.0	-1.8	-0.7	-0.7	-0.9	-0.5	-0.8
LDL Cholesterol	0.4	0.6	1.7	-0.1	-1.1	-1.3	-0.1	-0.6	0.2	-1.0	-1.1	-0.6	-1.0	-0.5
Lupus	0.4	0.6	1.8	0.8	0.7	-0.9	-0.9	0.5	0.4	0.8	1.1	0.3	0.2	1.3
Neuroticism (2016)	0.1	0.2	0.8	0.5	0.2	0.5	-0.9	0.3	-0.6	0.1	-0.1	0.3	0.2	0.0
Primary Biliary Cirrhosis	0.3	0.4	1.7	-0.2	0.5	-0.5	-1.3	0.1	0.5	0.6	0.7	0.3	0.7	0.2
Rheumatoid Arthritis	0.2	0.3	1.3	-0.0	0.3	-0.6	-1.1	0.2	0.8	0.4	0.4	0.0	0.2	0.4
Schizophrenia (2014)	0.6	1.4	3.8	1.0	1.3	-0.2	-0.1	1.9	0.2	1.3	1.4	1.6	1.0	1.3
Triglycerides	0.5	0.8	2.3	0.4	0.7	-0.2	0.7	1.0	1.5	0.9	0.8	1.1	0.8	0.9
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.1	0.2	0.6	0.3	-0.2	-0.0	0.2	0.3	-0.4	0.0	0.2
Ulcerative Colitis	1.4	2.1	5.6	1.7	1.4	-2.4	-0.4	1.5	0.7	1.3	1.4	1.5	1.0	1.7
Blood Eosinophil Count	0.1	0.5	2.3	-0.8	-0.7	0.5	1.5	0.2	0.7	-0.5	-0.3	-0.8	-0.5	-0.4
Blood Platelet Count	0.6	6.9	29.5	1.4	2.1	-0.2	5.4	3.0	2.1	2.3	2.2	2.0	2.2	2.7
Blood Red Count	0.2	1.7	4.0	-2.0	-1.6	1.0	0.3	-0.9	1.1	-1.3	-1.3	-1.4	-1.9	-0.5
Blood White Count	0.0	0.2	1.1	-0.1	-0.4	-1.0	-0.1	0.1	0.7	-0.2	-0.0	0.5	-0.5	-0.3
Heel T-Score	0.4	2.8	5.5	2.3	2.0	-0.3	0.9	1.6	-1.0	1.7	1.6	2.1	2.2	1.6
BMI	0.8	4.4	9.2	-2.6	-2.5	3.0	-0.1	-1.8	1.3	-2.1	-2.0	-2.3	-1.8	-2.2
Height	0.2	4.7	11.1	-0.8	-2.0	-2.3	-1.9	-2.5	-3.3	-2.3	-2.0	-2.2	-1.7	-1.9
Waist Hip Ratio (WHR)	0.2	1.1	4.5	-0.2	-0.7	-1.4	-2.1	-1.0	-0.6	-0.8	-0.7	-1.0	-1.1	-0.3
Systolic Blood Pressure	0.1	0.4	2.4	-0.9	-0.4	0.1	-0.1	-0.2	-1.5	-0.6	-0.4	-0.9	-0.0	-0.6
Smoking Status	0.8	1.8	17.0	0.1	-0.4	-0.6	-4.1	-0.5	0.8	-0.3	-0.2	-0.8	-1.0	0.2
Allergy or Eczema	0.5	1.3	3.2	0.0	-1.2	-1.4	-1.8	-0.9	-0.1	-1.2	-1.1	-1.2	-1.3	-0.7
Cardiovascular Disease	0.1	0.4	2.5	1.0	0.2	-0.8	-0.3	0.3	-1.6	-0.0	0.2	0.2	0.5	0.4
Hypothyroidism (self reported)	0.2	0.6	1.9	1.0	0.6	-1.4	0.2	0.5	-1.2	0.4	0.4	0.4	0.8	0.3
Respiratory disease	0.3	0.7	3.1	1.8	0.4	-0.8	-1.0	0.4	-1.5	0.2	0.4	0.5	0.5	0.1
Type 2 Diabetes (T2D) (2018)	1.2	2.3	4.4	-0.5	-1.7	0.6	-2.1	-1.9	-1.1	-1.7	-1.7	-1.6	-1.3	-1.7
Lung FEV1/FVC ratio	0.3	1.5	3.6	-0.4	-1.8	-0.6	0.6	-0.5	1.3	-1.5	-1.6	-0.8	-1.9	-1.1
Lung FVC	0.9	4.7	8.1	2.5	2.3	-2.8	-1.3	2.0	0.7	2.2	2.1	2.5	1.6	2.8
Neuroticism	0.2	0.6	2.5	1.2	0.6	-0.8	0.3	0.6	-1.6	0.3	0.3	0.6	0.6	0.4
Chronotype (morning person)	0.0	0.1	0.2	0.1	-0.1	0.1	-0.2	0.3	0.3	-0.2	-0.2	-0.4	-0.2	0.4
Hair Pigment	0.1	2.5	3.7	-1.9	-1.8	1.1	-0.6	-1.6	-0.6	-1.8	-1.9	-1.7	-1.9	-1.7
Tanning	0.3	4.0	6.2	1.8	2.2	0.6	2.0	2.0	1.2	2.3	2.2	2.4	2.5	2.0
Hand grip strength (left)	0.3	0.9	1.6	-1.1	-1.3	0.5	0.2	-0.8	0.2	-1.2	-1.3	-0.9	-1.1	-1.0
Number of treatments/medications taken	1.6	2.8	6.6	-0.8	-1.6	-0.9	-1.4	-1.5	-2.6	-2.0	-2.0	-1.7	-1.7	-1.8
Average weekly spirits intake	0.6	0.7	2.5	-0.7	-0.4	1.6	0.8	-0.5	-1.5	-0.4	-0.2	-0.9	0.3	-0.8
Sensitivity / hurt feelings	0.8	1.3	2.7	-0.6	-1.5	-0.3	-0.0	-0.9	-0.6	-1.6	-1.6	-1.4	-1.5	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	0.6	-0.5	-0.5	1.1	-0.0	0.4	-0.4	-0.4	0.2	-0.4	-0.3
Hearing difficulty/problems: Yes	0.5	0.8	3.3	-0.3	-1.0	-0.4	-0.3	-0.4	1.8	-0.8	-0.9	-0.7	-1.4	-0.2
Relative age of first facial hair	0.8	1.6	4.8	-0.7	-1.0	-0.5	-1.4	-1.5	-2.2	-1.3	-1.1	-1.1	-1.1	-1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.1	-1.1	-0.5	-0.3	-0.2	-0.2	1.0	-0.4	-0.4	-0.8	-0.3	-0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.3	2.5	1.2	1.6	-0.3	-0.1	1.0	-1.1	1.4	1.4	1.5	1.5	0.3
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.3	-0.8	0.2	-0.9	-0.6	0.2	-0.7	-0.8	-0.9	-0.5	-0.7
Systolic blood pressure, automated reading	0.5	1.4	2.9	-1.7	-1.5	0.3	-0.3	-0.8	-0.5	-1.4	-1.2	-1.6	-1.2	-1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.6	0.5	-0.9	-1.3	-1.1	-0.3	-0.7	-0.9	-0.8	-0.5	-0.8	-0.6
Angina	0.1	0.1	0.9	-0.4	0.2	0.9	0.2	-0.4	-0.1	0.2	0.1	-0.1	0.4	-0.3
Medication for hormone replacement therapy	0.5	0.6	1.1	1.1	0.9	-0.9	-0.4	0.4	-1.0	0.6	0.6	1.0	0.8	0.0
Vitamin and mineral supplements	0.3	0.4	2.4	-1.5	-0.2	0.2	-0.5	-0.5	0.9	-0.1	-0.1	-0.3	-0.3	-0.4
Supplements: Zinc	0.5	0.6	3.3	0.2	-0.2	0.3	1.1	-0.6	-1.8	-0.5	-0.5	-0.3	0.1	-0.6
Medication: Co-codamol	1.8	2.1	5.4	-2.3	-1.1	2.1	-0.1	-1.5	-1.3	-1.2	-1.1	-1.5	-0.4	-1.7
Medication: Metformin	2.5	3.6	8.5	-0.6	-2.1	0.7	-2.9	-2.1	-0.5	-2.1	-2.1	-2.4	-1.8	-1.7
Diabetes (father)	0.6	0.7	0.9	-0.8	-1.0	0.4	-1.0	-0.9	-0.5	-1.0	-0.9	-0.9	-0.7	-1.0
Diabetes (mother)	0.9	1.1	2.6	-1.4	-1.2	1.0	0.5	-1.0	-0.3	-1.1	-1.1	-0.8	-0.9	-1.6
Severe depression (siblings)	0.9	1.1	2.2	1.1	1.2	-1.5	0.9	1.2	-0.6	0.9	0.9	0.9	1.0	0.9
Pack years adult smoking proportion	0.4	0.5	1.4	-0.4	-0.9	-0.0	-1.2	-0.6	0.4	-0.8	-0.8	-0.9	-0.8	-0.6
Impedance of leg (right)	0.2	1.0	4.8	0.6	0.7	-1.2	2.2	-0.2	-1.6	0.3	0.4	0.3	0.5	0.4
Leg fat-free mass (left)	0.5	2.8	3.9	-2.0	-1.9	1.8	-1.8	-1.4	0.3	-1.7	-1.7	-1.9	-1.5	-1.9
Trunk fat percentage	1.0	4.1	7.1	-2.6	-2.3	2.2	0.5	-2.0	0.1	-2.1	-2.0	-2.7	-1.9	-2.1
Hand grip strength (right)	0.1	0.2	0.6	-0.6	-0.6	0.3	0.0	-0.3	0.8	-0.5	-0.5	-0.3	-0.6	-0.2
Townsend deprivation index at recruitment	0.8	1.1	4.5	-1.2	-0.7	2.1	1.5	-0.1	0.6	-0.6	-0.5	-0.4	-0.2	-1.2
Current tobacco smoking	0.4	0.7	3.7	-0.5	-0.4	0.2	-1.7	-0.2	1.9	-0.1	-0.1	-0.3	-0.3	-0.3
Average weekly fortified wine intake	0.6	0.8	4.7	-0.1	-0.1	0.2	-1.1	-1.3	-2.2	-0.4	-0.3	-0.5	-0.1	-0.6
Maternal smoking around birth	1.0	1.5	2.4	-1.0	-1.3	1.4	1.1	-0.5	1.6	-1.1	-1.2	-1.3	-1.4	-1.0
Fed-up feelings	0.2	0.3	2.1	0.5	-0.2	0.1	0.6	-0.4	-1.5	-0.4	-0.4	0.1	-0.0	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.6	-0.1	-0.4	0.2	0.2	0.1	-0.0	0.0	0.2	-0.1	-0.1
Relative age voice broke	0.6	1.0	2.7	1.6	0.8	-1.2	0.4	0.6	-1.6	0.5	0.6	1.2	0.6	0.8
Taking other prescription medications	0.7	1.1	5.3	-0.2	-0.3	-1.1	-2.3	-1.1	-1.4	-0.6	-0.6	-0.8	-0.8	-0.7
Age when periods started (menarche)	0.3	0.8	4.8	0.4	-0.4	-2.2	-1.3	-0.3	0.1	-0.5	-0.4	-0.1	-1.1	-0.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	0.2	0.3	1.1	0.2	0.3	-1.2	0.1	0.1	0.1	0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	0.6	0.6	0.0	1.1	0.9	0.0	0.5	0.5	0.5	0.8	0.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.2	-0.1	0.3	0.4	-0.3	0.6	-0.1	-0.1	-0.1	-0.5	-0.1
Qualifications: CSEs or equivalent	2.8	3.6	6.5	-0.3	-2.5	0.3	-0.5	-2.2	-0.5	-2.5	-2.4	-2.2	-2.3	-2.5
Serious illness, injury or assault to yourself	1.9	2.3	4.0	-1.6	-1.8	0.3	-0.0	-1.8	-0.4	-1.7	-1.6	-2.0	-1.7	-1.8
High blood pressure	0.1	0.3	1.2	0.4	0.5	-0.7	-0.3	0.4	-1.1	0.3	0.5	0.5	0.3	0.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.1	0.2	-0.8	-1.1	-1.8	-0.7	-0.7	-0.9	-0.9	-0.8	-0.9	-0.6
Multivitamins +/- minerals	0.1	0.1	0.5	0.7	-0.3	-0.0	0.2	0.2	-0.7	-0.4	-0.3	-0.2	-0.1	-0.1
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.0	0.4	0.6	0.1	0.3	-0.6	0.2	0.2	0.4	0.2	0.4
Supplements: Glucosamine	0.4	0.5	2.9	0.4	0.2	1.2	1.7	0.1	-0.9	0.1	0.2	-0.1	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	4.0	1.0	0.0	0.0	2.0	0.3	-1.1	-0.2	-0.3	0.7	0.1	-0.5
Medication: Atenolol	0.4	0.5	1.0	0.5	0.8	0.4	0.6	0.2	0.7	1.0	1.0	0.5	0.8	0.6
Medication: Levothyroxine sodium	0.2	0.4	3.2	-0.0	0.2	-1.8	-0.9	0.1	0.3	0.2	0.2	-0.5	-0.0	0.4
Sitting height	0.1	0.7	3.4	0.1	0.8	-0.3	-1.0	-0.0	-1.8	0.6	0.7	0.5	1.1	0.2
Chronic bronchitis/emphysema (father)	3.3	3.8	7.0	-2.6	-2.0	2.1	-1.0	-2.2	-0.2	-1.9	-1.9	-2.3	-1.7	-2.3
High blood pressure (mother)	0.2	0.3	1.9	-0.2	-0.4	-0.6	1.4	0.1	-0.0	-0.4	-0.5	-0.4	-0.4	-0.4
Body mass index (BMI)	1.0	4.5	6.9	-2.5	-2.5	2.6	-0.4	-1.8	0.9	-2.2	-2.1	-2.6	-1.9	-2.3
Impedance of leg (left)	0.3	1.6	4.2	1.4	1.1	-1.7	1.9	0.2	-2.0	0.7	0.8	0.8	0.9	0.9
Leg predicted mass (left)	0.6	3.0	4.1	-2.0	-1.9	1.9	-1.9	-1.4	0.4	-1.7	-1.7	-1.9	-1.5	-1.9
Trunk fat mass	1.1	4.7	8.1	-2.7	-2.6	2.3	-0.0	-2.2	0.3	-2.3	-2.2	-2.8	-2.1	-2.3
Waist circumference	1.5	5.5	9.0	-2.5	-2.8	1.8	-1.4	-2.3	0.3	-2.6	-2.5	-3.0	-2.5	-2.6
Number of incorrect matches in round	1.3	2.2	4.7	2.2	1.6	-1.2	0.8	1.3	-0.9	1.4	1.5	1.5	1.7	1.8
Past tobacco smoking	0.6	1.1	7.6	0.2	0.5	-0.2	2.8	0.7	0.1	0.6	0.7	1.1	1.4	-0.1
Alcohol usually taken with meals	0.2	0.3	1.3	-0.6	-0.5	1.1	0.3	-0.5	-0.6	-0.5	-0.6	-0.4	-0.5	-0.3
Nervous feelings	0.5	0.9	4.2	-0.3	-0.9	0.3	0.5	-0.9	-2.0	-1.0	-0.8	-1.1	-0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.7	0.1	-1.1	-0.4	0.1	-0.7	0.0	-1.1	-1.1	-0.6	-1.3	-0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-0.1	-0.7	-1.1	-0.6	-0.7	0.4	-0.7	-0.7	-0.5	-1.1	-0.3
Hair/balding pattern: Pattern 2	0.7	0.9	1.9	1.4	0.7	0.4	0.1	1.0	1.4	0.9	0.9	0.7	0.8	1.0
Had menopause	0.5	0.6	3.2	1.2	0.6	-1.1	0.2	0.3	-1.8	0.3	0.4	0.5	0.5	0.2
Had other major operations	0.7	0.9	1.8	-1.3	-0.8	-0.3	-1.0	-0.8	0.3	-0.9	-1.0	-0.9	-1.1	-1.4
Forced vital capacity (FVC)	0.1	0.3	1.2	0.5	0.3	-1.1	-0.6	0.0	-0.4	0.2	0.2	0.5	0.1	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	4.1	-0.4	-0.5	0.5	2.0	0.3	0.3	-0.5	-0.5	-0.4	-0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	-0.0	-0.7	-0.5	0.7	-0.4	0.0	-0.6	-0.6	-0.3	-0.6	-1.1
Qualifications: None of the above	0.2	0.3	1.7	1.0	0.1	-1.3	0.4	0.5	-0.6	0.0	-0.0	0.4	0.2	0.2
Financial difficulties in last 2 years	1.1	1.5	3.3	-1.3	-1.3	1.5	0.3	-1.2	-0.1	-1.3	-1.1	-1.8	-1.4	-1.1
Mouth/teeth dental problems	1.3	2.0	5.6	0.4	1.5	1.6	1.0	1.4	0.2	1.5	1.5	1.5	2.4	1.2
Heart attack	0.2	0.2	1.3	-0.1	0.3	-0.4	-1.1	0.0	-0.7	0.2	0.3	0.1	-0.1	0.3
Allergy	0.5	1.2	6.0	-1.6	0.2	1.9	2.4	0.2	0.7	0.3	0.2	0.1	0.4	0.1
Pain all over the body in last month	0.6	0.6	4.2	-1.0	-0.2	0.8	2.1	-0.1	0.8	-0.0	-0.1	-0.4	-0.1	-0.4
Diabetes (self-reported)	0.7	1.0	3.5	0.2	-0.9	0.5	-1.9	-1.2	-0.8	-1.0	-1.0	-1.0	-0.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	0.4	-0.9	-0.5	-0.7	-0.9	-1.1	-1.0	-0.8	-0.8	-0.8	-0.9
Medication: Ramipril	0.4	0.5	2.2	1.5	0.3	-1.4	0.0	0.1	-1.1	0.1	0.1	0.5	0.2	0.3
Medication: Simvastatin	0.3	0.4	0.8	-0.4	-0.5	0.6	-0.9	-0.7	-0.6	-0.7	-0.7	-0.9	-0.3	-0.5
Fluid intelligence score	0.2	0.3	0.8	-0.9	-0.3	0.9	0.7	-0.4	0.7	-0.3	-0.4	-0.6	-0.4	0.1
Illnesses of siblings	0.6	0.9	2.3	-0.6	-1.0	-0.5	-1.5	-0.6	0.8	-1.0	-1.1	-0.9	-1.3	-0.4
Neuroticism score	0.1	0.3	2.2	0.6	-0.2	-0.4	0.3	-0.0	-1.5	-0.4	-0.4	-0.0	-0.1	-0.4
Weight	1.2	5.9	9.5	-2.9	-2.9	2.4	-0.9	-2.4	0.1	-2.7	-2.5	-3.1	-2.2	-2.9
Impedance of arm (right)	0.2	0.9	3.6	0.6	0.8	-1.1	1.5	-0.1	-1.9	0.5	0.6	0.6	0.6	0.6
Arm fat percentage (right)	1.2	4.7	7.7	-2.7	-2.5	2.4	0.2	-2.1	0.3	-2.3	-2.1	-2.8	-2.0	-2.4
Trunk fat-free mass	0.2	1.2	3.8	-0.7	-1.1	0.8	-2.0	-0.8	-0.1	-1.1	-1.0	-1.1	-0.7	-1.3
Hip circumference	1.1	4.7	7.6	-2.5	-2.6	1.7	-0.5	-2.1	-0.3	-2.5	-2.4	-2.7	-2.0	-2.8
Time employed in main current job	2.4	2.8	7.8	-1.0	-1.4	0.2	-0.9	-2.2	-2.8	-1.7	-1.7	-1.5	-1.4	-2.0
Alcohol intake versus 10 years previously	1.2	1.8	4.5	0.8	1.4	-0.6	0.2	2.1	1.4	1.5	1.4	1.6	1.4	1.4
Father’s age at death	0.6	0.8	2.8	-0.2	-0.9	-0.0	-0.4	-1.0	-1.7	-1.0	-1.0	-0.4	-0.6	-1.2
Worrier / anxious feelings	1.0	1.9	10.7	0.9	-0.4	-2.5	-0.6	-0.5	-3.3	-0.9	-0.8	-0.1	-0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.2	-0.7	-0.4	1.1	1.8	-0.1	0.7	-0.3	-0.3	-0.4	-0.3	-0.8
Falls in the last year	4.3	5.8	8.7	-2.3	-2.9	0.9	1.0	-2.8	-0.2	-2.8	-2.8	-2.9	-2.9	-2.9
Hair/balding pattern: Pattern 3	0.6	0.8	1.4	-1.1	-0.9	-0.4	-0.4	-1.1	-0.1	-1.0	-1.2	-1.0	-1.2	-0.9
Number of live births	0.5	0.7	4.8	-1.2	-0.5	0.4	0.7	0.4	2.2	-0.1	-0.2	-0.2	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	1.1	0.7	-0.0	-1.0	-0.1	0.4	-0.0	-0.1	-0.1	0.5	-0.2	0.5
Pulse rate	2.7	4.6	10.3	-0.6	2.2	3.2	1.6	2.1	2.3	2.5	2.3	1.4	2.0	2.4
Happiness	0.7	0.8	1.9	-1.2	-0.9	0.6	1.4	-0.6	-0.5	-0.9	-0.9	-0.5	-0.5	-1.2
Noisy workplace	0.6	0.7	1.8	0.8	-0.7	-1.4	0.9	-0.5	-0.6	-0.8	-0.8	-0.5	-1.3	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.5	0.4	-0.0	0.1	0.4	0.4	0.5	0.5	0.7	0.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.4	-0.7	-1.0	0.6	0.8	-1.2	-1.0	-1.1	-1.1	-1.1	-0.7	-0.9
Mouth/teeth dental problems: Dentures	0.9	1.5	4.1	-0.2	-1.3	-1.6	-1.1	-1.1	-0.4	-1.3	-1.3	-1.5	-2.0	-0.8
Asthma	0.7	1.4	3.1	1.8	1.1	-1.4	-1.3	1.2	-0.0	1.1	1.3	1.1	1.1	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.3	0.5	-0.4	0.7	0.9	0.7	0.4	0.3	0.5	-0.2	0.6
Medication: Cholesterol lowering	0.3	0.5	2.8	0.6	0.6	0.8	-1.7	0.1	-0.6	0.5	0.5	0.3	0.7	0.4
Depression (self-reported)	2.1	2.5	4.6	-1.1	-1.8	1.3	-0.3	-1.9	-1.1	-1.9	-1.8	-2.1	-1.1	-2.2
Medication: Lansoprazole	0.2	0.2	0.5	0.2	0.5	-0.1	-0.1	0.7	0.4	0.5	0.5	0.6	0.4	0.4
Prospective memory result	1.5	1.8	6.2	1.9	1.0	-2.0	-1.0	0.4	-2.5	0.6	0.8	0.8	1.3	0.6
Lung cancer (father)	2.6	3.0	4.3	1.3	1.9	-0.3	1.4	2.0	1.7	2.1	2.1	1.8	1.8	2.0
Illnesses of mother	0.5	0.6	1.7	-0.3	0.6	1.3	-0.5	0.3	1.2	0.7	0.7	0.0	0.9	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.9	0.7	-0.6	-0.9	-0.1	-0.4	-0.6	-0.7	-0.8	0.0	-0.5	-0.3
Pulse wave Arterial Stiffness index	0.7	0.8	2.1	-1.5	-1.0	0.4	0.4	-0.2	1.4	-0.7	-0.8	-0.7	-1.1	-0.6
Impedance of arm (left)	0.3	1.2	4.1	0.9	1.1	-1.2	1.4	-0.0	-2.0	0.7	0.8	0.9	0.8	0.9
Arm fat mass (right)	1.2	4.9	8.1	-2.6	-2.7	2.4	-0.3	-2.2	0.1	-2.4	-2.3	-2.8	-2.1	-2.6
Trunk predicted mass	0.2	1.2	4.0	-0.8	-1.2	0.9	-2.0	-0.9	-0.2	-1.1	-1.0	-1.2	-0.8	-1.3
Standing height	0.1	1.1	3.0	-0.9	-0.9	-0.2	-0.9	-1.3	-1.7	-1.1	-1.0	-1.1	-0.7	-1.1
Length of working week for main job	0.6	0.7	3.9	-1.3	0.0	2.0	-0.5	0.3	1.3	0.2	0.2	0.1	-0.2	-0.1
Exposure to tobacco smoke at home	0.2	0.2	1.2	-0.5	0.3	1.1	0.4	0.1	0.2	0.3	0.3	0.1	0.5	0.1
Breastfed as a baby	0.3	0.3	2.2	-0.0	0.6	0.3	-0.2	-0.2	-1.5	0.3	0.4	0.1	0.7	0.2
Tense / ‘highly strung’	0.5	0.8	1.3	0.9	0.9	-0.2	1.1	1.1	-1.0	0.7	0.7	0.9	1.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-0.8	-1.2	-0.4	-0.8	-0.4	-0.0	-1.1	-1.2	-0.6	-1.3	-1.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	0.5	1.1	-0.5	-1.3	1.1	-0.5	1.1	1.1	1.5	1.1	0.7
Birth weight of first child	1.4	2.6	4.6	-1.4	-2.1	-0.5	0.3	-1.4	-0.2	-2.1	-2.1	-1.9	-1.9	-1.7
Peak expiratory flow (PEF)	0.5	1.2	2.3	-0.9	-1.3	0.5	0.1	-0.9	-0.9	-1.4	-1.5	-0.9	-1.3	-1.3
Pulse wave reflection index	1.4	1.7	2.8	-1.3	-1.6	-1.1	0.0	-1.4	0.1	-1.4	-1.4	-1.2	-1.7	-1.7
Ever highly irritable/argumentative for 2 days	1.6	2.0	3.0	-1.5	-1.7	1.4	1.1	-1.1	0.4	-1.5	-1.4	-1.4	-1.5	-1.7
Loud music exposure frequency	1.6	1.7	3.2	-0.8	-1.6	1.0	-0.3	-1.6	0.3	-1.5	-1.5	-1.8	-1.5	-1.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	2.0	-1.4	-0.5	1.0	-0.6	-0.3	0.3	-0.3	-0.3	-0.1	-0.4	-0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	-0.5	-0.5	0.6	0.4	-0.2	0.7	-0.4	-0.4	-0.1	-0.6	-0.6
Blood clot in the leg (DVT)	0.6	0.7	1.5	1.2	0.5	-1.2	-1.0	0.8	1.2	0.6	0.5	0.8	0.4	0.7
Medication: Paracetamol	2.2	3.6	8.8	-1.7	-2.3	-1.5	-0.3	-1.5	0.7	-2.2	-2.4	-1.8	-3.0	-1.9
Headache pain in last month	0.4	0.7	4.1	0.7	0.1	-2.0	-1.0	0.9	0.6	0.2	0.2	0.7	-0.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	2.4	-0.1	0.2	-0.4	1.5	0.6	1.0	0.3	0.3	0.6	0.2	0.1
Glaucoma (self-reported)	0.4	0.5	2.2	-0.6	0.6	1.5	0.2	0.3	0.7	0.7	0.6	0.2	0.6	0.8
Gout (self-reported)	0.2	0.2	1.4	0.3	0.4	0.3	0.5	-0.0	-1.2	0.2	0.2	-0.2	0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	3.2	-0.1	-0.2	-1.8	0.2	-0.5	-0.4	-0.4	-0.4	-0.8	-0.4	-0.2
Medication: Amlodipine	0.7	0.9	4.2	1.3	0.2	-2.0	-1.8	-0.2	-0.9	0.0	0.1	0.3	-0.3	0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.6	-0.2	-0.6	-1.2	-1.3	-0.1	0.1	-0.5	-0.4	-0.3	-0.5	-0.6
Birth weight	0.5	1.0	6.6	0.7	-0.1	-1.9	-2.6	0.0	0.4	-0.0	-0.0	-0.0	-0.5	0.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	-0.2	-1.1	-0.3	-1.2	-0.5	0.8	-0.9	-1.0	-1.0	-1.4	-0.6
High blood pressure (siblings)	0.5	0.8	4.5	-0.5	0.1	1.1	0.8	-0.8	-2.1	-0.2	-0.1	-0.5	0.4	-0.8
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	0.6	-0.4	-1.0	-0.7	-0.8	-1.0	-0.6	-0.7	-0.1	-0.3	-0.2
Body fat percentage	1.2	4.6	8.0	-2.8	-2.5	2.3	0.5	-2.1	0.4	-2.2	-2.1	-2.8	-2.0	-2.2
Leg fat percentage (right)	1.6	5.7	9.7	-3.1	-2.8	2.2	0.9	-2.3	0.8	-2.5	-2.4	-3.1	-2.4	-2.5
Arm fat-free mass (right)	0.4	1.8	3.1	-1.3	-1.5	1.5	-1.8	-1.1	-0.0	-1.4	-1.3	-1.6	-1.1	-1.6
Exposure to tobacco smoke outside home	6.3	8.4	14.7	-2.4	-3.5	1.1	-0.2	-3.1	-1.2	-3.6	-3.7	-3.1	-3.4	-3.8
Comparative body size at age 10	0.4	1.1	5.5	1.7	0.2	-1.8	-2.3	-0.2	-0.8	0.1	0.1	0.4	0.3	0.1
Number of full brothers	0.5	0.6	2.1	1.5	0.5	-1.0	-0.5	0.7	-0.4	0.5	0.5	1.1	0.6	0.3
Worry too long after embarrassment	0.9	1.5	3.8	1.0	1.2	0.5	1.9	1.7	0.4	1.2	1.1	1.2	1.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.1	-0.2	-0.6	0.1	0.2	0.3	-0.2	-0.2	-0.0	-0.2	-0.7
Wheeze or whistling in the chest in last year	0.4	0.7	2.3	-0.4	-0.8	0.2	-1.5	-0.1	0.8	-0.7	-0.7	-0.3	-1.2	-0.9
Number of children fathered	0.9	1.0	3.4	-1.5	-0.5	1.6	1.3	0.4	1.8	-0.2	-0.4	-0.5	-0.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.1	0.3	1.5	0.5	0.5	1.4	0.9	1.5	1.4	1.4	1.8	1.3
Age at first live birth	0.4	0.7	3.1	1.0	0.4	-1.8	-0.0	0.9	0.0	0.3	0.2	1.3	0.1	0.6
Pulse wave peak to peak time	0.7	0.8	3.1	1.3	0.9	-0.2	-0.4	0.1	-1.8	0.6	0.8	0.6	1.1	0.5
Health satisfaction	1.3	1.6	3.3	-0.2	-1.5	0.2	-0.5	-1.8	-0.8	-1.5	-1.5	-1.5	-1.5	-1.6
Shortness of breath walking on level ground	1.1	1.3	2.9	0.4	-1.5	-0.5	-1.0	-0.9	-0.4	-1.5	-1.5	-0.8	-1.7	-1.3
Qualifications: College or University degree	0.2	0.6	1.5	0.6	1.0	0.0	0.8	0.3	-1.2	0.8	0.9	0.5	0.9	1.0
Eye problems/disorders: None of the above	0.2	0.2	1.6	0.0	0.2	-0.2	1.3	0.5	0.4	0.3	0.3	0.4	0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.7	-0.5	0.0	1.3	1.3	0.1	0.1	0.1	0.1	-0.2	0.3	-0.1
Emphysema/chronic bronchitis	2.8	3.2	5.0	-1.4	-2.1	0.8	-1.7	-1.9	-0.5	-2.1	-2.1	-1.8	-2.2	-2.1
Medication for pain relief, constipation, heartburn	1.4	2.3	4.8	1.0	1.7	1.2	0.2	1.4	0.8	1.9	2.0	1.4	2.2	1.8
Neck or shoulder pain in last month	0.1	0.1	0.6	-0.4	0.4	-0.1	0.8	0.0	-0.2	0.3	0.3	-0.2	0.3	0.3
Medication: Blood pressure	0.3	0.5	2.5	0.8	0.6	-0.6	-1.6	0.5	-0.2	0.5	0.5	0.5	0.2	0.9
Angina (self-reported)	0.2	0.2	1.7	-0.4	0.2	1.3	0.1	-0.4	-0.1	0.2	0.2	-0.1	0.4	-0.3
Migraine (self-reported)	0.1	0.1	0.4	-0.6	0.2	-0.4	0.3	0.4	-0.2	0.2	0.2	0.5	0.1	-0.5
Medication: Ibuprofen	0.1	0.1	0.5	-0.7	0.1	-0.1	0.6	0.3	0.0	-0.0	-0.1	-0.1	-0.4	0.1
Medication: Allopurinol	0.5	0.7	1.3	0.3	1.1	-0.2	1.0	0.3	-1.1	0.8	0.8	0.4	1.1	0.9
Medication: Omeprazole	0.3	0.3	2.4	-0.1	0.3	0.3	0.5	-0.5	-1.5	0.0	0.1	-0.4	0.3	0.1
Medication: Seretide 50 evohaler	2.4	2.7	4.5	-0.5	-1.9	-1.5	0.0	-1.8	-1.6	-2.1	-2.0	-1.6	-1.9	-1.9
Mean time to correctly identify matches	0.2	0.3	2.2	0.1	-0.1	0.9	-1.5	-0.1	-0.3	-0.0	0.1	-0.3	0.3	-0.6
Heart disease (mother)	0.4	0.5	1.5	0.7	1.1	-0.2	-0.4	0.5	-0.4	1.0	0.9	1.2	0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.5	1.1	1.1	-0.0	0.5	1.6	-0.1	1.1	1.1	1.6	0.9	0.6
Whole body fat mass	1.0	4.4	7.7	-2.7	-2.4	2.4	-0.2	-2.1	0.2	-2.2	-2.0	-2.8	-1.9	-2.2
Leg fat mass (right)	1.6	6.3	10.7	-3.3	-2.9	2.6	-0.2	-2.4	0.8	-2.6	-2.5	-3.3	-2.4	-2.7
Arm predicted mass (right)	0.2	1.2	2.3	-1.0	-1.2	1.3	-1.5	-0.8	0.3	-1.1	-1.0	-1.3	-0.8	-1.3
Pulse rate, automated reading	1.7	5.5	22.7	-2.6	0.9	4.8	0.7	1.1	4.7	1.5	1.3	0.1	0.7	1.4
Alcohol intake frequency.	0.1	0.3	1.5	-0.4	-0.1	1.2	0.9	0.2	0.4	0.1	0.2	-0.3	0.3	-0.1
Comparative height size at age 10	0.2	0.9	2.1	-1.5	-1.2	-0.1	-0.5	-0.6	-0.4	-1.1	-1.0	-1.1	-0.8	-1.3
Number of full sisters	0.5	0.6	3.6	-0.5	-0.6	-0.3	-1.9	-0.1	-0.0	-0.6	-0.7	-0.5	-0.7	-0.7
Suffer from ‘nerves’	0.2	0.3	1.5	0.4	-0.6	-1.2	0.5	0.3	0.6	-0.4	-0.4	-0.2	-0.4	-0.2
Overall health rating	0.2	0.5	1.1	-0.7	-0.8	0.7	0.5	-0.8	-0.0	-0.7	-0.7	-0.7	-0.8	-1.0
Chest pain or discomfort	0.1	0.2	0.8	-0.2	-0.5	-0.1	0.7	-0.3	0.9	-0.3	-0.3	-0.2	-0.7	-0.3
Had major operations	0.4	0.5	1.6	-0.9	-0.7	-0.4	0.6	-0.1	0.4	-0.7	-0.7	-0.3	-1.3	-0.7
Age at last live birth	0.3	0.4	1.3	0.1	0.3	-1.1	-0.4	0.8	0.9	0.5	0.4	1.1	0.2	0.4
Family relationship satisfaction	0.7	0.9	2.1	-0.1	-1.1	-0.5	0.6	-0.9	-1.4	-1.2	-1.1	-0.6	-0.7	-1.2
Leg pain on walking	0.5	0.6	3.7	1.1	-0.4	-1.9	-0.2	-0.3	-0.6	-0.5	-0.4	-0.5	-0.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.8	-1.2	-1.3	0.4	-0.3	-0.6	0.7	-1.1	-1.1	-1.1	-1.3	-1.0
Commuting to job workplace: Car/motor vehicle	4.0	4.6	7.0	-1.7	-2.6	0.7	-1.1	-2.5	-0.4	-2.6	-2.6	-2.5	-2.4	-2.6
Illness, injury, bereavement, stress in last 2 years	2.4	3.0	5.1	1.5	2.2	-0.8	-0.3	1.6	-0.4	2.1	2.1	2.2	2.2	1.9
Medication: Aspirin	1.0	1.3	2.6	-0.6	-1.1	0.2	-0.8	-1.5	-1.6	-1.2	-1.2	-1.1	-1.1	-1.5
Supplements: Vitamin C	1.1	1.3	3.3	1.8	1.2	-1.8	-0.6	0.7	0.0	1.0	1.0	1.1	0.6	1.3
Knee pain experienced in last month	1.3	2.1	3.3	-1.6	-1.7	1.6	-0.2	-1.3	1.4	-1.4	-1.5	-1.8	-1.6	-1.2
Hypertension (Self-reported)	0.1	0.3	1.4	0.5	0.5	-0.6	-0.4	0.5	-1.2	0.3	0.5	0.4	0.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.8	0.4	0.1	-1.3	-1.1	-0.2	-0.8	-0.1	-0.0	0.5	0.1	-0.2
Illnesses of father: Heart disease	0.6	0.9	3.5	-0.5	-0.3	1.9	0.5	-0.4	-1.8	-0.5	-0.4	-0.6	0.8	-0.9
Illnesses of siblings: Diabetes	1.3	1.6	3.3	-0.6	-1.7	-0.5	-0.3	-1.1	-0.2	-1.6	-1.5	-1.2	-1.8	-1.7
Smoking status: Previous	0.7	1.1	4.2	-0.5	-0.7	0.2	-2.1	-1.0	-0.8	-0.9	-0.9	-1.4	-1.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	3.8	-0.9	-1.8	0.4	0.3	-1.9	-1.8	-1.9	-1.9	-1.5	-1.2	-2.0
Whole body fat-free mass	0.4	2.1	4.1	-1.4	-1.6	1.3	-2.0	-1.2	0.0	-1.5	-1.4	-1.6	-1.1	-1.7
Leg fat-free mass (right)	0.5	2.7	4.5	-1.7	-1.9	1.6	-2.1	-1.3	0.1	-1.7	-1.7	-1.8	-1.4	-1.9
Arm fat percentage (left)	1.0	3.9	6.5	-2.5	-2.3	2.4	0.2	-1.9	0.4	-2.0	-1.9	-2.5	-1.8	-2.1
Average weekly red wine intake	0.4	0.6	5.0	-0.5	-0.0	2.2	0.9	-0.0	-0.9	-0.1	0.0	-0.4	0.1	0.2
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.7	-1.3	-0.9	-0.5	-0.4	-0.3	0.4	-0.8	-0.7	-0.8	-0.6	-0.9
Mood swings	0.9	1.6	3.0	-0.9	-1.5	-0.5	-1.1	-1.3	-0.4	-1.5	-1.5	-1.4	-1.4	-1.7
Loneliness, isolation	1.9	2.6	4.8	2.1	1.8	-0.3	-0.8	1.7	0.0	1.8	1.8	2.2	1.8	1.5
Long-standing illness, disability or infirmity	0.8	1.2	2.3	-1.3	-1.1	-0.3	-0.7	-1.3	-0.6	-1.2	-1.2	-1.5	-1.3	-1.2
Ever had bowel cancer screening	0.4	0.4	2.7	-0.7	-0.1	0.9	1.6	0.1	0.7	0.1	0.1	0.0	0.2	-0.2
Diabetes diagnosed by doctor	1.5	2.4	3.8	-0.5	-1.7	1.0	-1.8	-1.9	-0.9	-1.8	-1.7	-1.9	-1.4	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.7	-0.2	-0.2	0.3	0.7	0.1	0.8	-0.0	-0.0	-0.2	-0.0	0.0
Friendships satisfaction	0.4	0.5	4.1	-0.2	-0.1	0.1	2.0	-0.3	-0.9	-0.2	-0.1	0.2	0.3	-0.7
Qualifications: nursing, teaching	1.2	1.8	5.0	-2.2	-1.5	0.5	0.5	-1.2	0.8	-1.4	-1.4	-1.3	-1.5	-1.3
Commuting to job workplace: Walk	5.2	5.6	9.1	2.2	3.0	-0.2	-0.8	2.7	0.0	2.9	2.9	2.7	3.0	2.5
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.3	-0.4	-0.2	-0.5	-0.3	0.2	-0.4	-0.4	-0.3	-0.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.6	0.3	-0.5	-1.6	0.2	0.0	1.1	-0.4	-0.5	0.2	-1.3	-0.2
Medication for cholesterol	0.3	0.4	2.8	0.2	0.1	-0.1	-0.7	0.7	1.7	0.4	0.3	0.3	-0.2	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.2	6.2	-1.3	-2.3	-0.2	-0.3	-1.8	-0.3	-2.3	-2.3	-1.6	-2.4	-2.5
Back pain experienced in last month	0.2	0.3	1.7	-0.6	0.1	-0.7	0.7	0.8	1.3	0.2	0.1	0.2	-0.1	0.2
Mineral and other dietary supplements	1.4	1.8	3.8	-0.9	-1.5	-0.9	-1.9	-1.4	0.5	-1.4	-1.5	-1.0	-1.7	-1.4
Breast cancer (self-reported)	0.6	0.7	1.3	-0.7	-0.9	0.5	-0.2	-1.0	-0.0	-1.0	-1.1	-1.0	-1.0	-0.9
Asthma (self-reported)	0.5	1.1	2.8	1.7	1.0	-1.0	-1.1	1.0	-0.1	1.0	1.1	0.9	1.0	0.9
Osteoporosis (self-reported)	0.9	1.2	3.1	-0.2	-1.2	-0.8	-1.8	-0.6	0.6	-1.1	-1.1	-1.0	-1.7	-0.6
Osteoarthritis (self-reported)	0.7	0.9	1.6	0.1	1.1	-1.0	1.3	1.2	0.7	1.1	1.0	0.9	0.7	1.1
Medication: Aspirin	0.6	0.7	1.5	-0.5	-0.7	0.1	-0.9	-1.2	-1.2	-0.8	-0.8	-0.9	-0.8	-0.9
Medication: Gliclazide	7.0	8.0	12.5	-2.3	-3.2	1.4	-2.7	-3.4	-0.1	-3.1	-3.2	-3.5	-3.1	-3.0
Illnesses of father: None of the above (group 1)	1.5	1.9	6.1	0.7	1.0	-1.7	0.8	1.5	2.5	1.3	1.2	1.5	0.2	1.5
Smoking status: Current	0.4	0.7	3.6	-0.4	-0.4	0.4	-1.7	-0.2	1.9	-0.1	-0.2	-0.4	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.2	-0.6	-0.9	-0.8	2.0	-0.7	-0.7	-1.1	-1.3	-0.4	-1.0	-0.9
Whole body water mass	0.3	1.9	3.3	-1.3	-1.6	1.4	-1.8	-1.1	0.1	-1.4	-1.3	-1.5	-1.1	-1.7
Leg predicted mass (right)	0.5	2.5	4.4	-1.7	-1.8	1.6	-2.1	-1.3	0.2	-1.6	-1.6	-1.7	-1.4	-1.8
Arm fat mass (left)	1.1	4.3	7.1	-2.5	-2.4	2.6	-0.1	-2.0	0.3	-2.1	-2.0	-2.7	-1.8	-2.3
Number of self-reported non-cancer illnesses	0.8	1.4	6.7	1.5	0.3	-1.6	-1.8	-0.4	-2.6	-0.1	0.0	0.1	0.4	-0.3
Average weekly champagne plus white wine intake	0.2	0.2	0.7	-0.3	-0.3	0.4	0.1	-0.7	-0.8	-0.4	-0.5	-0.0	-0.4	-0.4
Miserableness	0.5	0.8	3.6	0.2	-0.7	-1.0	-1.9	-0.6	-0.8	-0.8	-0.7	-0.6	-0.7	-0.7
Guilty feelings	0.1	0.2	0.5	0.2	-0.3	0.4	-0.7	0.1	-0.5	-0.4	-0.5	-0.1	-0.4	-0.4
Wears glasses or contact lenses	0.9	1.1	2.5	1.2	0.6	-1.0	-1.6	1.3	0.7	0.8	0.9	1.4	0.5	0.6
Ever taken oral contraceptive pill	0.9	1.1	2.3	-1.5	-1.0	0.8	0.1	-0.9	-0.9	-1.1	-1.1	-1.1	-0.8	-1.3
Hearing aid user	0.4	0.5	3.0	0.2	0.3	0.6	1.1	-0.4	-1.7	-0.1	-0.1	-0.1	0.2	-0.2
Mother’s age at death	1.8	2.3	4.7	1.2	1.8	-1.2	0.1	1.7	0.6	1.7	1.6	2.2	1.4	2.0
Financial situation satisfaction	1.9	2.3	4.0	-2.0	-1.7	0.7	1.7	-1.6	-0.3	-1.6	-1.6	-1.5	-1.4	-1.7
Tinnitus: Yes, now most or all of the time	2.4	2.8	5.3	-0.8	-1.7	-1.5	-1.2	-2.0	-1.5	-1.9	-1.8	-1.8	-2.3	-1.5
Commuting to job workplace: Public transport	1.3	1.5	6.9	0.8	0.8	-1.9	-2.6	0.9	0.2	0.8	0.9	1.1	0.2	1.3
Eye problems/disorders: Glaucoma	1.3	1.6	2.7	0.5	1.6	1.5	0.0	1.1	1.0	1.6	1.5	1.1	1.5	1.4
Medication: Blood pressure	0.1	0.3	1.5	-0.1	-0.2	-0.2	0.6	-0.6	-1.2	-0.4	-0.3	-0.5	-0.2	-0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	3.1	-0.6	-0.7	0.3	-1.8	-0.3	1.1	-0.6	-0.6	-1.0	-0.8	-0.1
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.6	1.3	1.7	0.1	1.7	1.6	-0.6	1.6	1.6	1.4	1.9	1.5
High cholesterol (Self-reported)	0.6	1.1	3.1	1.2	1.3	0.3	0.1	0.9	-0.9	1.0	1.0	0.8	1.8	1.0
Medication: Bendroflumethiazide	0.5	0.7	3.3	0.9	0.7	-1.3	-0.6	0.3	-1.8	0.4	0.5	0.3	0.3	0.7
Medication: Paracetamol	1.5	2.3	5.4	-1.5	-1.6	-1.5	-0.7	-1.0	0.6	-1.6	-1.9	-1.4	-2.3	-1.5
Medication: Lisinopril	0.2	0.2	0.6	-0.2	0.5	0.7	-0.8	0.1	-0.3	0.5	0.5	0.0	0.7	0.3
Medication: Atorvastatin	1.0	1.2	5.9	-0.6	-0.6	1.2	0.9	-0.9	-2.4	-0.9	-0.8	-1.0	-0.4	-0.8
Illnesses of father: High blood pressure	0.7	0.9	3.7	1.8	0.6	-1.1	0.4	0.3	-1.9	0.3	0.5	0.7	0.6	0.5
Alcohol drinker status: Never	1.1	1.3	3.2	-0.1	-1.1	1.0	0.8	-1.0	-1.5	-1.2	-1.2	-1.1	-0.6	-1.8
Ever smoked	0.4	0.8	6.4	0.1	-0.2	0.3	-2.5	-0.5	0.2	-0.3	-0.4	-0.7	-1.0	0.2
Basal metabolic rate	0.5	2.8	4.1	-1.7	-1.9	1.5	-1.8	-1.5	-0.0	-1.8	-1.7	-2.0	-1.4	-2.0
Leg fat percentage (left)	1.3	4.6	8.2	-2.6	-2.6	1.9	0.6	-2.0	0.6	-2.4	-2.2	-2.9	-2.2	-2.3
Arm fat-free mass (left)	0.4	2.1	3.5	-1.3	-1.7	1.3	-1.9	-1.2	0.0	-1.5	-1.5	-1.7	-1.2	-1.8
Number of operations (self-reported)	1.1	1.6	3.6	-1.4	-1.4	0.7	0.8	-1.0	-0.2	-1.4	-1.5	-1.3	-1.5	-1.9
Average weekly beer plus cider intake	0.9	1.4	4.6	1.9	0.9	-2.1	-0.7	0.9	0.8	0.9	0.8	0.9	0.7	1.2
Irritability	0.6	1.0	8.0	1.0	0.2	-1.1	-1.0	-0.3	-2.8	-0.2	-0.0	0.1	-0.0	-0.2
Risk taking	0.4	0.6	1.7	1.2	0.6	0.1	0.1	1.3	0.4	0.6	0.5	1.3	0.9	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	-1.0	-0.4	0.9	-0.7	-0.2	0.3	-0.3	-0.4	-0.1	-0.6	-0.3
Fractured/broken bones in last 5 years	0.2	0.3	1.0	0.7	0.1	1.0	-0.0	0.1	0.8	0.3	0.4	0.5	0.5	0.2
Age started oral contraceptive pill	0.9	1.1	1.7	0.9	1.3	-1.1	1.0	1.1	-0.3	1.1	1.0	1.2	1.2	0.9
Diastolic blood pressure, automated reading	1.8	5.5	15.4	-3.8	-2.2	3.9	1.1	-1.5	1.3	-1.8	-1.8	-2.5	-1.8	-2.2
Ever depressed for a whole week	0.4	0.5	1.7	0.6	-0.8	0.1	0.2	-0.7	-0.9	-0.8	-0.8	-0.3	-0.4	-1.3
Unable to work because of sickness or disability	2.1	2.8	5.0	-1.8	-1.8	0.9	-0.5	-1.8	-1.2	-1.8	-1.8	-2.2	-1.6	-2.0
Commuting to job workplace: Cycle	0.6	0.7	3.4	0.7	0.6	-1.8	1.2	0.8	0.2	0.5	0.4	0.6	0.4	0.8
Myopia	0.4	0.5	1.7	-1.2	-0.2	0.5	1.3	0.7	1.2	0.0	-0.1	0.3	0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.2	-0.4	0.8	0.7	-0.1	0.8	-0.3	-0.5	-0.2	-0.1	-0.4
Cholesterol lowering medication	0.6	0.9	4.0	-0.4	-0.7	0.6	0.4	-1.0	-2.0	-1.0	-0.9	-1.3	-0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	2.2	0.3	0.5	0.4	-0.3	-0.2	-1.5	0.3	0.3	-0.0	0.6	0.2
Pain experienced in last month	0.3	0.5	1.5	1.2	0.6	-0.2	1.2	0.4	-0.3	0.5	0.6	0.6	0.8	0.6
Supplements: Calcium	0.4	0.5	1.2	-0.5	-0.5	0.5	-1.1	-0.5	-0.8	-0.7	-0.8	-1.0	-0.3	-0.7
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	-0.2	-1.0	1.0	1.1	-0.7	-0.6	-1.1	-1.1	-0.6	-0.5	-0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.5	-0.1	0.4	-0.3	-1.2	-0.0	-0.9	0.3	0.3	0.1	0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.1	1.3	0.4	-1.4	-1.3	0.7	1.1	0.6	0.5	0.8	0.4	0.5
Heart disease (siblings)	0.5	0.6	1.1	0.6	0.8	0.5	1.1	0.7	-0.6	0.7	0.7	1.0	0.8	0.4
Alcohol drinker status: Previous	0.3	0.4	1.0	-1.0	-0.6	0.3	-0.8	-0.4	0.4	-0.5	-0.4	-0.9	-0.8	-0.5
Pack years of smoking	0.2	0.3	0.9	-0.5	-0.6	-0.1	-0.9	-0.2	0.8	-0.5	-0.6	-0.6	-0.6	-0.2
Impedance of whole body	0.2	1.1	4.4	0.9	0.8	-1.5	1.6	-0.2	-2.1	0.4	0.5	0.5	0.5	0.6
Leg fat mass (left)	1.4	5.5	9.2	-2.9	-2.8	2.4	-0.3	-2.2	0.7	-2.5	-2.4	-3.0	-2.3	-2.5
Arm predicted mass (left)	0.4	2.0	3.3	-1.3	-1.7	1.0	-1.6	-1.2	0.1	-1.6	-1.5	-1.7	-1.2	-1.8